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Guido Silvestri

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Raj Kurupati; Marcio O Lasaro; Mark Lewis; Sarah J Ratcliffe; Marina Sazanovich; Louise C Showe; Guido Silvestri; Steve Tuyishime; Steven E Bosinger; Diane G Carnathan; Larissa H Haut; Andrew V Kossenkov; Hildegund C J Ertl
Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques.
Steven E Bosinger; Kathryn A Folkner; Timothy L Hayes; Simon P Jochems; Nichole R Klatt; Guido Silvestri
Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239.
Luca Micci; Savita Pahwa; Aftab A Ansari; Jason M Brenchley; Barbara Cervasi; James ELSE; Zachary S Ende; Jacob D Estes; Robin I Iriele; Elane Reyes-Aviles; Guido Silvestri; Francios VILLINGER; Carol Vinton; Mirko Paiardini
Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques.

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All Publications

2013: Raj Kurupati; Marcio O Lasaro; Mark Lewis; Sarah J Ratcliffe; Marina Sazanovich; Louise C Showe; Guido Silvestri; Steve Tuyishime; Steven E Bosinger; Diane G Carnathan; Larissa H Haut; Andrew V Kossenkov; Hildegund C J Ertl
Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques.
Journal of leukocyte biology 2013;93(3):437-48.
2013: Steven E Bosinger; Kathryn A Folkner; Timothy L Hayes; Simon P Jochems; Nichole R Klatt; Guido Silvestri
Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239.
Journal of virology 2013;87(1):433-43.
2012: Luca Micci; Savita Pahwa; Aftab A Ansari; Jason M Brenchley; Barbara Cervasi; James ELSE; Zachary S Ende; Jacob D Estes; Robin I Iriele; Elane Reyes-Aviles; Guido Silvestri; Francios VILLINGER; Carol Vinton; Mirko Paiardini
Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques.
Blood 2012;120(19):3925-35.
2012: Ming Zeng; Mirko Paiardini; Timothy W Schacker; Guido Silvestri; Greg J Beilman; Jeffrey G Chipman; Jessica Engram; Ashley T Haase
Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution.
Blood 2012;120(9):1856-67.
2012: Kiran D Mir; Maud Mavigner; Guido Silvestri
The myeloid cytokine network in AIDS pathogenesis.
Cytokine & growth factor reviews 2012;23(4-5):223-31.
2012: Saikat Boliar; Diane G Carnathan; Megan K Murphy; Guido Silvestri; T Cameron Tran; Wendy S Armstrong; Cynthia A Derdeyn
B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth.
Journal of virology 2012;86(15):8031-40.
2012: Kiran D Mir; Guido Silvestri; Steven E Bosinger; Jason M Brenchley; James ELSE; Melanie Gasper; On Ho; Shiu-Lok Hu; David J Kelvin; Donald L Sodora
Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
Journal of virology 2012;86(14):7605-15.
2012: Thomas H Vanderford; Francios VILLINGER; Chloe Slichter; Steven E Bosinger; James ELSE; Benton O Lawson; Rend Obaede; Kenneth A Rogers; Guido Silvestri
Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.
Blood 2012;119(24):5750-7.
2012: Ravi Dyavar; Steven E Bosinger; Gordon J Freeman; Guido Silvestri; Kehmia Titanji; Vijayakumar Velu; Rama Rao Amara
PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques.
The Journal of clinical investigation 2012;122(5):1712-6.
2012: Ann Chahroudi; Guido Silvestri
IRIS: the unfortunate rainbow of HIV.
Blood 2012;119(13):2971-2.
2012: Ann Chahroudi; Mirko Paiardini; Steven E Bosinger; Thomas H Vanderford; Guido Silvestri
Natural SIV hosts: showing AIDS the door.
Science (New York, N.Y.) 2012;335(6073):1188-93.
2012: Nichole R Klatt; Guido Silvestri
CD4+ T cells and HIV: A paradoxical Pas de Deux.
Science translational medicine 2012;4(123):123ps4.
2012: Sandrine Souquiere; Guido Silvestri; Cristian Apetrei; Ann Chahroudi; Ivona Pandrea; Pierre Roques
Reply to "Control of Simian Immunodeficiency Virus SIVmnd-1 RNA Plasma Viremia after Coinfection or Superinfection with SIVmnd-1 in SIVmnd-2-Infected Mandrills and Vice Versa".
Journal of virology 2012;86(4):2387-8.
2012: Irene Puga; Sergi Serrano; Meimei Shan; Guido Silvestri; Wayne Tam; Núria Torán; Montserrat Torrebadell; Weifeng Xu; Jordi Yagüe; Francesc Alameda; Juan Ignacio Aróstegui; Teresa Baró; Carolina M Barra; Beatriz Bellosillo; J Magarian Blander; James B Bussel; Michaela Calvillo; Carmen Carreras; Jean-Laurent Casanova; Linda Cassis; Albert Català; Kang Chen; April Chiu; Alejo Chorny; Montserrat Cols; Laura Comerma; Charlotte Cunningham-Rundles; Victoria Cusí; Cristina Díaz de Heredia; George A Diaz; Andreas Diefenbach; Jean Donadieu; Carlo Dufour; Claire-Michèle Farber; Claudia Fortuny; Stephanie C Ganal; Maurizio Gentile; Bing He; Manel Juan; Nuria Juanpere; Daniel M Knowles; Josep Lloreta; José Antonio Lorente; Vassilios Lougaris; Giuliana Magri; Nizar Mahlaoui; Lucia Dora Notarangelo; Alessandro Plebani; Andrea Cerutti
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen.
Nature immunology 2012;13(2):170-80.
2012: Jessica E Taaffe; Christopher D Ward; Steven E Bosinger; Gregory Q Del Prete; James ELSE; Thi Migone; Mirko Paiardini; Sarah Ratcliffe; Guido Silvestri
CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques.
Journal of medical primatology 2012;41(1):24-42.
2012: Nichole R Klatt; Guido Silvestri; Vanessa Hirsch
Nonpathogenic simian immunodeficiency virus infections.
Cold Spring Harbor perspectives in medicine 2012;2(1):a007153.
2012: Steven E Bosinger; Guido Silvestri; Béatrice Jacquelin; Arndt Benecke; Michaela Müller-Trutwin
Systems biology of natural simian immunodeficiency virus infections.
Current opinion in HIV and AIDS 2012;7(1):71-8.
2012: Sarah T C Elliott; Mirko Paiardini; Nicholas Francella; Guido Silvestri; Donald L Sodora; Nadeene E Riddick; Cynthia A Derdeyn; Bing Li; Cristian Apetrei; Thomas H Vanderford; Ronald G Collman
Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.
Journal of virology 2012;86(2):898-908.
2012: Nichole R Klatt; Carol L Vinton; Louis J Picker; Heather E Cronise; Thomas H Vanderford; Richard M Dunham; Bernard A P Lafont; Joanna M Swerczek; Lauren A Canary; Guido Silvestri; Jessica C Engram; Jason M Brenchley
Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.
Journal of virology 2012;86(2):1203-13.
2011: Cristian Apetrei; Ann Chahroudi; Maria Makuwa; Ivona Pandrea; Patricia Reed; Ruy M Ribeiro; Pierre Roques; Sandrine Souquiere; Beth Sumpter; Guido Silvestri
Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx).
Journal of virology 2011;85(24):13077-87.
2011: Steven E Bosinger; Zachary P Johnson; Guido Silvestri
Primate genomes for biomedicine.
Nature biotechnology 2011;29(11):983-4.
2011: Alexandra M Ortiz; Mirko Paiardini; Sarah Ratcliffe; Elena Ryzhova; Lawrence Sternberg; Brian Tabb; Yanjie Yi; Aftab A Ansari; Jason M Brenchley; Paul M Carnathan; Ronald G Collman; Elizabeth M Cramer; Cynthia A Derdeyn; James ELSE; Jessica Engram; Jacob D Estes; Francisco Gonzalez-Scarano; Xing Pei Hao; Nichole R Klatt; Benton Lawson; Bing Li; Dawn M Little; Guido Silvestri
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.
The Journal of clinical investigation 2011;121(11):4433-45.
2011: Samir K Lakhashe; Guido Silvestri; Ruth M Ruprecht
No acquisition: a new ambition for HIV vaccine development?
Current opinion in virology 2011;1(4):246-53.
2011: Suefen Kwa; Pragati Nigam; Ravi Dyavar; Mariam Siddiqui; Guido Silvestri; Aftab A Ansari; Wendy Armstrong; Steven E Bosinger; Sunil Kannanganat; Rama Rao Amara
Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques.
Blood 2011;118(10):2763-73.
2011: Marjet Elemans; Christos Gkekas; Nichole R Klatt; Nafisa-Katrin Seich Al Basatena; Guido Silvestri; Becca Asquith
Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
PLoS computational biology 2011;7(9):e1002200.
2011: Steven E Bosinger; Donald L Sodora; Guido Silvestri
Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.
Current opinion in HIV and AIDS 2011;6(5):411-8.
2011: Carol Vinton; ruth woodward; Cristian Apetrei; Judith A Briant; Levelle D Harris; Richard Herbert; Vanessa M Hirsch; Nichole R Klatt; Ivona Pandrea; Brigitte E Sanders-Beer; Guido Silvestri; Jason M Brenchley
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology 2011;85(17):8702-8.
2011: David L Reed; Alberto Severini; William M Shafer; Paul M Sharp; Guido Silvestri; Steven A Sullivan; Shaun Tyler; Magnus Unemo; Shelley F Walton; Jane M Carlton; Ian N Clarke; Melissa Conrad; Russell W Currier; Andrew J Davison; R Eberle; Beatrice H Hahn; Welkin E Johnson; Teresa Lagergård; Sheila A Lukehart; Peter Norberg; Timothy D Read; R Palmer Beasley; Tomas Bergström; Jonas Blomberg
The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms.
Annals of the New York Academy of Sciences 2011;1230():74-107.
2011: Andre Durudas; Vasudha Sundaravaradan; Welkin Johnson; Melanie A Gasper; Luis D Giavedoni; Hui-Ling Chen; Jeffrey M Milush; Guido Silvestri; Donald L Sodora
Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.
Current HIV research 2011;9(5):276-88.
2011: Mirko Paiardini; Ivona Pandrea; Elane Reyes-Aviles; Nadeene E Riddick; Timothy Schlub; Carol Vinton; Cristian Apetrei; Steven E Bosinger; Jason M Brenchley; Barbara Cervasi; Ann Chahroudi; Ming Liang Chan; Ronald G Collman; Elizabeth Cramer; Miles P Davenport; James ELSE; Nicholas Francella; Shari N Gordon; Paul L Hallberg; Frank Kirchhoff; Luca Micci; Jan Munch; Alexandra M Ortiz; Guido Silvestri
Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression.
Nature medicine 2011;17(7):830-6.
2011: Margalida Rotger; Judith Dalmau; Andri Rauch; Paul McLaren; Steven E Bosinger; Raquel Martinez; Netanya G Sandler; Annelys Roque; Julia Liebner; Manuel Battegay; Enos Bernasconi; Patrick Descombes; Itziar Erkizia; Jacques Fellay; Bernard Hirschel; Jose M Miró; Eduard Palou; Matthias Hoffmann; Marta Massanella; Julià Blanco; Matthew Woods; Huldrych F Günthard; Paul de Bakker; Daniel C Douek; Guido Silvestri; Javier Martinez-Picado; Amalio Telenti
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
The Journal of clinical investigation 2011;121(6):2391-400.
2011: Ann Chahroudi; Tracy Meeker; Benton Lawson; Sarah J Ratcliffe; James ELSE; Guido Silvestri
Mother-to-infant transmission of simian immunodeficiency virus is rare in sooty mangabeys and is associated with low viremia.
Journal of virology 2011;85(12):5757-63.
2011: Thomas H Vanderford; Chelsea Bleckwehl; Jessica Engram; Richard Dunham; Nichole R Klatt; Mark B Feinberg; David A Garber; Michael R Betts; Guido Silvestri
Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.
PLoS pathogens 2011;7(5):e1002048.
2011: Gabriella d'Ettorre; Marileda Indinnimeo; Claudio M Mastroianni; Mirko Paiardini; Cecilia Rizza; Guido Silvestri; Stefano Vella; Mauro Andreotti; Giancarlo Ceccarelli; Lorenzo Zaffiri; Vincenzo Vullo
HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS.
Current HIV research 2011;9(3):148-53.
2011: Gabriella d'Ettorre; Mirko Paiardini; Giancarlo Ceccarelli; Guido Silvestri; Vincenzo Vullo
HIV-associated immune activation: from bench to bedside.
AIDS research and human retroviruses 2011;27(4):355-64.
2011: Ming Zeng; Anthony J Smith; Stephen W Wietgrefe; Peter J Southern; Timothy W Schacker; Cavan S Reilly; Jacob D Estes; GREGORY BURTON; Guido Silvestri; Jeffrey D Lifson; John V Carlis; Ashley T Haase
Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections.
The Journal of clinical investigation 2011;121(3):998-1008.
2011: Jeffrey M Milush; Kiran D Mir; Vasudha Sundaravaradan; Shari N Gordon; Jessica Engram; Christopher A Cano; Jacqueline D Reeves; Elizabeth Anton; Eduardo O'Neill; Eboneé Butler; Kathy Hancock; Kelly S Cole; Jason M Brenchley; James ELSE; Guido Silvestri; Donald L Sodora
Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.
The Journal of clinical investigation 2011;121(3):1102-10.
2011: Marcio O Lasaro; Larissa H Haut; Xiangyang Zhou; Zhiquan Xiang; Dongming Zhou; Yan Li; Wynetta Giles-Davis; Hua Li; Jessica C Engram; Lauren J Dimenna; Ang Bian; Marina Sazanovich; Elizabeth M Parzych; Raj Kurupati; Juliana C Small; Te-Lang Wu; Rachel M Leskowitz; Nicole R Klatt; Jason M Brenchley; David A Garber; Mark Lewis; Sarah J Ratcliffe; Michael R Betts; Guido Silvestri; Hildegund C J Ertl
Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):417-26.
2010: Ming Liang Chan; Janka Petravic; Alexandra M Ortiz; Jessica Engram; Mirko Paiardini; Deborah Cromer; Guido Silvestri; Miles P Davenport
Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys.
Proceedings. Biological sciences / The Royal Society 2010;277(1701):3773-81.
2010: Shari N Gordon; Barbara Cervasi; Pamela Odorizzi; Randee Silverman; Faten Aberra; Gregory Ginsberg; Jacob D Estes; Mirko Paiardini; Ian Frank; Guido Silvestri
Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5169-79.
2010: Ann Chahroudi; Guido Silvestri
Interleukin-7 in HIV pathogenesis and therapy.
European cytokine network 2010;21(3):202-7.
2010: Jessica C Engram; Barbara Cervasi; Jose A M Borghans; Nichole R Klatt; Shari N Gordon; Ann Chahroudi; James ELSE; Robert S Mittler; Donald L Sodora; Rob J de Boer; Jason M Brenchley; Guido Silvestri; Mirko Paiardini
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Blood 2010;116(5):748-58.
2010: Levelle D Harris; Brian Tabb; Donald L Sodora; Mirko Paiardini; Nichole R Klatt; Daniel C Douek; Guido Silvestri; Michaela Müller-Trutwin; Ivona Vasile-Pandrea; Cristian Apetrei; Vanessa Hirsch; Jeffrey Lifson; Jason M Brenchley; Jacob D Estes
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.
Journal of virology 2010;84(15):7886-91.
2010: Jason M Brenchley; Guido Silvestri; Daniel C Douek
Nonprogressive and progressive primate immunodeficiency lentivirus infections.
Immunity 2010;32(6):737-42.
2010: Bing Li; Kelly Stefano Cole; David M Kuhrt; Shari N Gordon; James ELSE; Joseph Mulenga; Susan Allen; Donald L Sodora; Guido Silvestri; Cynthia A Derdeyn
Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies.
Journal of virology 2010;84(12):6248-53.
2010: Andrea Costantini; Simona Giuliodoro; Luca Butini; Guido Silvestri; Pietro Leoni; Maria Montroni
HIV-induced abnormalities in myelopoiesis and their recovery following antiretroviral therapy.
Current HIV research 2010;8(4):336-9.
2010: Jessica Taaffe; Ann Chahroudi; Jessica Engram; Beth Sumpter; Tracy Meeker; Sarah J Ratcliffe; Mirko Paiardini; James ELSE; Guido Silvestri
A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation.
Journal of virology 2010;84(11):5476-84.
2010: Donald L Sodora; Guido Silvestri
HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here.
Current opinion in HIV and AIDS 2010;5(2):111-3.
2010: Nadeene E Riddick; Emilia A Hermann; Lamorris M Loftin; Sarah T Elliott; Winston C Wey; Barbara Cervasi; Jessica Taaffe; Jessica Engram; Bing Li; James ELSE; Yingying Li; Beatrice H Hahn; Cynthia A Derdeyn; Donald L Sodora; Cristian Apetrei; Mirko Paiardini; Guido Silvestri; Ronald G Collman
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.
PLoS pathogens 2010;6(8):e1001064.
2010: Roger D Kouyos; Shari N Gordon; Silvija I Staprans; Guido Silvestri; Roland R Regoes
Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.
PLoS computational biology 2010;6(8):.
2010: Jacob D Estes; Levelle D Harris; Nichole R Klatt; Brian Tabb; Stefania Pittaluga; Mirko Paiardini; G Robin Barclay; Jeremy Smedley; Rhonda Pung; Kenneth M Oliveira; Vanessa M Hirsch; Guido Silvestri; Daniel C Douek; Christopher J Miller; Ashley T Haase; Jeffrey Lifson; Jason M Brenchley
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections.
PLoS pathogens 2010;6(8):e1001052.
2010: Nichole R Klatt; Emi Shudo; Alex M Ortiz; Jessica C Engram; Mirko Paiardini; Benton Lawson; Michael D Miller; James ELSE; Ivona Pandrea; Jacob D Estes; Cristian Apetrei; Joern E Schmitz; Ruy M Ribeiro; Alan S Perelson; Guido Silvestri
CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.
PLoS pathogens 2010;6(1):e1000747.
2009: Steven E Bosinger; Qingsheng Li; Shari N Gordon; Nichole R Klatt; Lijie Duan; Luoling Xu; Nicholas Francella; Abubaker Sidahmed; Anthony J Smith; Elizabeth M Cramer; Ming Zeng; David Masopust; John V Carlis; Longsi Ran; Thomas H Vanderford; Mirko Paiardini; R Benjamin Isett; Don A Baldwin; James ELSE; Silvija I Staprans; Guido Silvestri; Ashley T Haase; David J Kelvin
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.
The Journal of clinical investigation 2009;119(12):3556-72.
2009: Béatrice Jacquelin; Véronique Mayau; Brice Targat; Anne-Sophie Liovat; Désirée Kunkel; Gaël Petitjean; Marie-Agnès Dillies; Pierre Roques; Cécile Butor; Guido Silvestri; Luis D Giavedoni; Pierre Lebon; Françoise Barré-Sinoussi; Arndt Benecke; Michaela C Müller-Trutwin
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response.
The Journal of clinical investigation 2009;119(12):3544-55.
2009: Andre Durudas; Jeffrey M Milush; Hui-Ling Chen; Jessica C Engram; Guido Silvestri; Donald L Sodora
Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.
Journal of virology 2009;83(23):12229-40.
2009: Devon Shedlock; Guido Silvestri; David B Weiner
Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials.
Nature reviews. Immunology 2009;9(10):717-28.
2009: Andrea Costantini; Simona Giuliodoro; Luca Butini; Guido Silvestri; Pietro Leoni; Maria Montroni
Abnormalities of erythropoiesis during HIV-1 disease: a longitudinal analysis.
Journal of acquired immune deficiency syndromes (1999) 2009;52(1):70-4.
2009: Donald L Sodora; Jonathan S Allan; Cristian Apetrei; Jason M Brenchley; Daniel C Douek; James ELSE; Jacob D Estes; Beatrice H Hahn; Vanessa M Hirsch; Amitinder Kaur; Frank Kirchhoff; Michaela Muller-Trutwin; Ivona Pandrea; Joern schmitz; Guido Silvestri
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.
Nature medicine 2009;15(8):861-5.
2009: Matthew D H Lay; Janka Petravic; Shari N Gordon; Jessica Engram; Guido Silvestri; Miles P Davenport
Is the gut the major source of virus in early simian immunodeficiency virus infection?
Journal of virology 2009;83(15):7517-23.
2009: Brandon F Keele; James Holland Jones; Karen A Terio; Jacob D Estes; Rebecca S Rudicell; Michael Wilson; Yingying Li; Gerald Learn; Timothy M Beasely; Joann Schumacher-Stankey; Emily Wroblewski; Anna Mosser; Jane Raphael; Shadrack Kamenya; Elizabeth V Lonsdorf; Dominic A Travis; Titus Mlengeya; Michael J Kinsel; James ELSE; Guido Silvestri; Jane Goodall; Paul M Sharp; George M Shaw; Anne E Pusey; Beatrice H Hahn
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz.
Nature 2009;460(7254):515-9.
2009: Jessica C Engram; Richard M Dunham; George Makedonas; Thomas H Vanderford; Beth Sumpter; Nichole R Klatt; Sarah J Ratcliffe; Seema Garg; Mirko Paiardini; Monica McQuoid; John D Altman; Silvija I Staprans; Michael R Betts; David A Garber; Mark B Feinberg; Guido Silvestri
Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):706-17.
2009: Irini Sereti; Richard M Dunham; John Spritzler; Evgenia Aga; Michael A Proschan; Kathy Medvik; Catherine A Battaglia; Alan L Landay; Savita Pahwa; Margaret A Fischl; David M Asmuth; Allan Tenorio; John D Altman; Lawrence Fox; Susan Moir; Angela Malaspina; Michel MORRE; Renaud Buffet; Guido Silvestri; Michael M Lederman
IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection.
Blood 2009;113(25):6304-14.
2009: Nia Tatsis; Marcio O Lasaro; Shih-Wen Lin; Larissa H Haut; Zhi Q Xiang; Dongming Zhou; Lauren Dimenna; Hua Li; Ang Bian; Sarah Abdulla; Yan Li; Wynetta Giles-Davis; Jessica Engram; Sarah J Ratcliffe; Guido Silvestri; Hildegund C J Ertl; Michael R Betts
Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6587-99.
2009: Alexandra M Ortiz; Guido Silvestri
Immunopathogenesis of AIDS.
Current infectious disease reports 2009;11(3):239-45.
2009: Malavika S Giri; Michael Nebozyhn; Andrea Raymond; Bethsebah Gekonge; Aidan Hancock; Shenoa Creer; Calen Nicols; Malik Yousef; Andrea S Foulkes; Karam Mounzer; Jane Shull; Guido Silvestri; Jay R Kostman; Ronald G Collman; Louise C Showe; Luis J Montaner
Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4459-70.
2009: Vijayakumar Velu; Kehmia Titanji; Baogong Zhu; Sajid Husain; Annette Pladevega; Lilin Lai; Thomas H Vanderford; Lakshmi Chennareddi; Guido Silvestri; Gordon J Freeman; Rafi Ahmed; Rama Rao Amara
Enhancing SIV-specific immunity in vivo by PD-1 blockade.
Nature 2009;458(7235):206-10.
2009: Mirko Paiardini; Jackie Hoffman; Barbara Cervasi; Alexandra M Ortiz; Fawn Stroud; Guido Silvestri; Mark E. Wilson
T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys.
Brain, behavior, and immunity 2009;23(2):286-93.
2009: Mirko Paiardini; Barbara Cervasi; Jessica C Engram; Shari N Gordon; Nichole R Klatt; Alagarraju Muthukumar; James ELSE; Robert S Mittler; Silvija I Staprans; Donald L Sodora; Guido Silvestri
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
Blood 2009;113(3):612-21.
2009: Mirko Paiardini; Ivona Pandrea; Cristian Apetrei; Guido Silvestri
Lessons learned from the natural hosts of HIV-related viruses.
Annual review of medicine 2009;60():485-95.
2009: Jan Schmökel; Hui Li; Elizabeth Bailes; Michael Schindler; Guido Silvestri; Beatrice H Hahn; Cristian Apetrei; Frank Kirchhoff
Conservation of Nef function across highly diverse lineages of SIVsmm.
Retrovirology 2009;6():36.
2009: German Gornalusse; Srinivas Mummidi; Weijing He; Guido Silvestri; Mike Bamshad; Sunil Ahuja
CCL3L Copy number variation and the co-evolution of primate and viral genomes.
PLoS genetics 2009;5(1):e1000359.
2009: Ivona Pandrea; Guido Silvestri; Cristian Apetrei
AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infection.
Current HIV research 2009;7(1):57-72.
2009: Guido Silvestri
Immunity in natural SIV infections.
Journal of internal medicine 2009;265(1):97-109.
2008: Angela Meier; Amelia Fisher; Harlyn K Sidhu; Judy J Chang; Tom F Wen; Hendrik Streeck; Galit Alter; Guido Silvestri; Marcus Altfeld
Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture.
Journal of immunological methods 2008;339(2):132-40.
2008: Guido Silvestri
AIDS pathogenesis: a tale of two monkeys.
Journal of medical primatology 2008;37 Suppl 2():6-12.
2008: Karuppiah Muthumani; Andrew Y Choo; Devon Shedlock; Dominick J Laddy; Senthil G Sundaram; Lauren Hirao; Ling Wu; Khanh P Thieu; Christopher W Chung; Karthikbabu M Lankaraman; Pablo Tebas; Guido Silvestri; David B Weiner
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism.
Journal of virology 2008;82(23):11536-44.
2008: Max W Richardson; Richard G Carroll; Matthew Stremlau; Nikolay Korokhov; Laurent M Humeau; Guido Silvestri; Joseph Sodroski; James L Riley
Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha.
Journal of virology 2008;82(22):11117-28.
2008: Jason M Brenchley; Mirko Paiardini; Kenneth S Knox; Ava I Asher; Barbara Cervasi; Tedi E Asher; Phillip Scheinberg; David A Price; Chadi A Hage; Lisa M Kholi; Alexander Khoruts; Ian Frank; James ELSE; Timothy W Schacker; Guido Silvestri; Daniel C Douek
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.
Blood 2008;112(7):2826-35.
2008: Ivona Pandrea; Donald L Sodora; Guido Silvestri; Cristian Apetrei
Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.
Trends in immunology 2008;29(9):419-28.
2008: Michael Schindler; Jan Schmökel; Anke Specht; Hui Li; Jan Münch; Mohammad Khalid; Donald L Sodora; Beatrice H Hahn; Guido Silvestri; Frank Kirchhoff
Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.
PLoS pathogens 2008;4(7):e1000107.
2008: Nichole R Klatt; Francios VILLINGER; Pavel Bostik; Shari N Gordon; Lara Pereira; Jessica Engram; Ann Mayne; Richard Dunham; Benton Lawson; Sarah J Ratcliffe; Donald L Sodora; James ELSE; Keith Reimann; Silvija I Staprans; Ashley T Haase; Jacob D Estes; Guido Silvestri; Aftab A Ansari
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
The Journal of clinical investigation 2008;118(6):2039-49.
2008: Ivona Pandrea; Richard Onanga; Sandrine Souquiere; Augustin Mouinga-Ondéme; Olivier Bourry; Maria Makuwa; Pierre Rouquet; Guido Silvestri; François SIMON; Pierre Roques; Cristian Apetrei
Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding.
Journal of virology 2008;82(11):5501-9.
2008: Jacob D Estes; Shari N Gordon; Ming Zeng; Ann M Chahroudi; Richard M Dunham; Silvija I Staprans; Cavan S Reilly; Guido Silvestri; Ashley T Haase
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6798-807.
2008: Frank Kirchhoff; Guido Silvestri
Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?
The Journal of clinical investigation 2008;118(5):1622-5.
2008: Richard Dunham; Barbara Cervasi; Jason M Brenchley; Helmut Albrecht; Amy Weintrob; Beth Sumpter; Jessica Engram; Shari Gordon; Nichole R Klatt; Ian Frank; Donald L Sodora; Daniel C Douek; Mirko Paiardini; Guido Silvestri
CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5582-92.
2008: Ivona Pandrea; Ruy M Ribeiro; Rajeev Gautam; Thaidra Gaufin; Melissa Pattison; Mary Barnes; Christopher Monjure; Crystal Stoulig; Jason Dufour; Wayne Cyprian; Guido Silvestri; M Miller; Alan S Perelson; Cristian Apetrei
Simian immunodeficiency virus SIVagm dynamics in African green monkeys.
Journal of virology 2008;82(7):3713-24.
2008: Shari N Gordon; Richard Dunham; Jessica Engram; Jacob Estes; Zichun Wang; Nichole R Klatt; Mirko Paiardini; Ivona Pandrea; Cristian Apetrei; Donald L Sodora; Ha Youn Lee; Ashley T Haase; M Miller; Amitinder Kaur; Silvija I Staprans; Alan S Perelson; Mark B Feinberg; Guido Silvestri
Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis.
Journal of virology 2008;82(7):3725-35.
2008: Donald L Sodora; Guido Silvestri
Immune activation and AIDS pathogenesis.
AIDS (London, England) 2008;22(4):439-46.
2008: David Kosub; Ginger Lehrman; Jeffrey M Milush; Dejiang Zhou; Elizabeth Chacko; Amanda Leone; Shari Gordon; Guido Silvestri; James ELSE; Philip Keiser; Mamta K Jain; Donald L Sodora
Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.
Journal of virology 2008;82(3):1155-65.
2008: Marie-Christine Cumont; Ousmane M Diop; Bruno VASLIN; Carole Elbim; Laurence Viollet; Valérie Monceaux; Stéphanie Lay; Guido Silvestri; Roger Le Grand; Michaela C Müller-Trutwin; Bruno Hurtrel; Jérôme Estaquier
Early divergence in lymphoid tissue apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates.
Journal of virology 2008;82(3):1175-84.
2008: Mirko Paiardini; Ian Frank; Ivona Pandrea; Cristian Apetrei; Guido Silvestri
Mucosal immune dysfunction in AIDS pathogenesis.
AIDS reviews 2008;10(1):36-46.
2007: Valérie Monceaux; Laurence Viollet; Frédéric Petit; Marie-Christine Cumont; G R Kaufmann; Anne-Marie Aubertin; Bruno Hurtrel; Guido Silvestri; Jérôme Estaquier
CD4+ CCR5+ T-cell dynamics during simian immunodeficiency virus infection of Chinese rhesus macaques.
Journal of virology 2007;81(24):13865-75.
2007: Guido Silvestri; Mirko Paiardini; Ivona Pandrea; Michael M Lederman; Donald L Sodora
Understanding the benign nature of SIV infection in natural hosts.
The Journal of clinical investigation 2007;117(11):3148-54.
2007: Jeffrey M Milush; Jacqueline D Reeves; Shari N Gordon; Dejiang Zhou; Alagarraju Muthukumar; David Kosub; Elizabeth Chacko; Luis D Giavedoni; Chris C Ibegbu; Kelly S Cole; John L Miamidian; Mirko Paiardini; Ashley P Barry; Silvija I Staprans; Guido Silvestri; Donald L Sodora
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3047-56.
2007: Ivona Pandrea; Rajeev Gautam; Ruy M Ribeiro; Jason M Brenchley; Isolde F Butler; Melissa Pattison; Terri Rasmussen; Preston A Marx; Guido Silvestri; Andrew Lackner; Alan S Perelson; Daniel C Douek; Ronald S Veazey; Cristian Apetrei
Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3035-46.
2007: Shari N Gordon; Nichole R Klatt; Steven E Bosinger; Jason M Brenchley; Jeffrey M Milush; Jessica Engram; Richard Dunham; Mirko Paiardini; Sara Klucking; Ali Danesh; Elizabeth Strobert; Cristian Apetrei; Ivona Pandrea; David J Kelvin; Daniel C Douek; Silvija I Staprans; Donald L Sodora; Guido Silvestri
Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3026-34.
2007: Cristian Apetrei; Rajeev Gautam; Beth Sumpter; Anders C Carter; Thaidra Gaufin; Silvija I Staprans; James ELSE; Mary Barnes; Robert Cao; Seema Garg; Jeffrey M Milush; Donald L Sodora; Ivona Pandrea; Guido Silvestri
Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys.
Journal of virology 2007;81(15):7913-23.
2007: Ashley P Barry; Guido Silvestri; Jeffrey T Safrit; Beth Sumpter; Natalia Kozyr; Harold M McClure; Silvija I Staprans; Mark B Feinberg
Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8002-12.
2007: Rajeev Gautam; Anders Chase Carter; Nathalia Katz; Isolde F Butler; Mary Barnes; Atsuhiko Hasegawa; Marion S Ratterree; Guido Silvestri; Preston A Marx; Vanessa M Hirsch; Ivona Pandrea; Cristian Apetrei
In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques.
Virology 2007;362(2):257-70.
2007: Beth Sumpter; Richard Dunham; Shari Gordon; Jessica Engram; Margaret Hennessy; Audrey Kinter; Mirko Paiardini; Barbara Cervasi; Nichole Klatt; Harold M McClure; Jeffrey M Milush; Silvija I Staprans; Donald L Sodora; Guido Silvestri
Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1680-91.
2007: Ivona Pandrea; Cristian Apetrei; Shari Gordon; Joseph Barbercheck; Jason Dufour; Rudolf Bohm; Beth Sumpter; Pierre Roques; Preston A Marx; Vanessa M Hirsch; Amitinder Kaur; Andrew Lackner; Ronald S Veazey; Guido Silvestri
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts.
Blood 2007;109(3):1069-76.
2006: Jason M Brenchley; David A Price; Timothy W Schacker; Tedi E Asher; Guido Silvestri; SRINIVAS RAO; Zachary Kazzaz; Ethan Bornstein; Olivier Lambotte; Daniel Altmann; Bruce R Blazar; Benigno Rodriguez; Leia Teixeira-Johnson; Alan Landay; Jeffrey N Martin; Frederick Hecht; Louis J Picker; Michael M Lederman; Steven G Deeks; Daniel C Douek
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Nature medicine 2006;12(12):1365-71.
2006: Mauro Magnani; Mirko Paiardini; Barbara Cervasi; Sonja Serafini; Alessandra Fraternale; Guido Silvestri
Fludarabine delivery by autologous red blood cells induces macrophage depletion in chronically SIV-infected Sooty Mangabeys.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e45-7.
2006: Barbara Cervasi; Mirko Paiardini; Sonja Serafini; Alessandra Fraternale; M Menotta; Jessica Engram; B Lawson; Silvija I Staprans; Giuseppe Piedimonte; Carlo Federico Perno; Guido Silvestri; Mauro Magnani
Administration of fludarabine-loaded autologous red blood cells in simian immunodeficiency virus-infected sooty mangabeys depletes pSTAT-1-expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy.
Journal of virology 2006;80(21):10335-45.
2006: Andrea Costantini; Simona Giuliodoro; Stefania Mancini; Luca Butini; Christina M Regnery; Guido Silvestri; Francesco Greco; Pietro Leoni; Maria Montroni
Impaired in-vitro growth of megakaryocytic colonies derived from CD34 cells of HIV-1-infected patients with active viral replication.
AIDS (London, England) 2006;20(13):1713-20.
2006: Ivona Pandrea; Guido Silvestri; Richard Onanga; Ronald S Veazey; Preston A Marx; Vanessa M Hirsch; Cristian Apetrei
Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences.
Journal of medical primatology 2006;35(4-5):194-201.
2006: Richard Dunham; Paola Pagliardini; Shari Gordon; Beth Sumpter; Jessica Engram; Abeer Moanna; Mirko Paiardini; Judith N Mandl; Benton Lawson; Seema Garg; Harold M McClure; Yong-Xian Xu; Chris C Ibegbu; Kirk Easley; Nathalia Katz; Ivona Pandrea; Cristian Apetrei; Donald L Sodora; Silvija I Staprans; Mark B Feinberg; Guido Silvestri
The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus.
Blood 2006;108(1):209-17.
2006: Michael Schindler; Jan Münch; Olaf Kutsch; Hui Li; Mario L Santiago; Frederic Bibollet-Ruche; Michaela C Müller-Trutwin; Francis J Novembre; Martine Peeters; Valerie Courgnaud; Elizabeth Bailes; Pierre Roques; Donald L Sodora; Guido Silvestri; Paul M Sharp; Beatrice H Hahn; Frank Kirchhoff
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Cell 2006;125(6):1055-67.
2006: Cristian Apetrei; Nicholas W Lerche; Ivona Pandrea; Bobby J Gormus; Guido Silvestri; Amitinder Kaur; David L Robertson; Johnny Hardcastle; Andrew Lackner; Preston A Marx
Kuru experiments triggered the emergence of pathogenic SIVmac.
AIDS (London, England) 2006;20(3):317-21.
2006: Mirko Paiardini; Barbara Cervasi; Beth Sumpter; Harold M McClure; Donald L Sodora; Mauro Magnani; Silvija I Staprans; Giuseppe Piedimonte; Guido Silvestri
Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys.
Journal of virology 2006;80(2):634-42.
2005: Alagarraju Muthukumar; Dejiang Zhou; Mirko Paiardini; Ashley P Barry; Kelly S Cole; Harold M McClure; Silvija I Staprans; Guido Silvestri; Donald L Sodora
Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys.
Blood 2005;106(12):3839-45.
2005: Guido Silvestri
Naturally SIV-infected sooty mangabeys: are we closer to understanding why they do not develop AIDS?
Journal of medical primatology 2005;34(5-6):243-52.
2005: Ann Chahroudi; Rahul Chavan; Natalia Kozyr; Natalia Koyzr; Edmond WALLER; Guido Silvestri; Mark B Feinberg
Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor.
Journal of virology 2005;79(16):10397-407.
2005: Cynthia A Derdeyn; Guido Silvestri
Viral and host factors in the pathogenesis of HIV infection.
Current opinion in immunology 2005;17(4):366-73.
2005: Bruno Hurtrel; Frédéric Petit; Damien Arnoult; Michaela C Müller-Trutwin; Guido Silvestri; Jérôme Estaquier
Apoptosis in SIV infection.
Cell death and differentiation 2005;12 Suppl 1():979-90.
2005: J D Miller; David Masopust; E John Wherry; Susan M Kaech; Guido Silvestri; Rafi Ahmed
Differentiation of CD8 T cells in response to acute and chronic viral infections: implications for HIV vaccine development.
Current drug targets. Infectious disorders 2005;5(2):121-9.
2005: Guido Silvestri; Andrew Fedanov; Stephanie Germon; Natalia Kozyr; William J Kaiser; David A Garber; Harold M McClure; Mark B Feinberg; Silvija I Staprans
Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts.
Journal of virology 2005;79(7):4043-54.
2005: Mirko Paiardini; Barbara Cervasi; Helmut Albrecht; Alagarraju Muthukumar; Richard Dunham; Shari Gordon; Henry Radziewicz; Giuseppe Piedimonte; Mauro Magnani; Maria Montroni; Susan M Kaech; Amy Weintrob; John D Altman; Donald L Sodora; Mark B Feinberg; Guido Silvestri
Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2900-9.
2005: Abeer Moanna; Richard Dunham; Mirko Paiardini; Guido Silvestri
CD4+ T-cell depletion in HIV infection: killed by friendly fire?
Current HIV/AIDS reports 2005;2(1):16-23.
2004: Silvija I Staprans; Ashley P Barry; Guido Silvestri; Jeffrey T Safrit; Natalia Kozyr; Beth Sumpter; Hanh Nguyen; Harold M McClure; David Montefiori; Jeffrey I Cohen; Mark B Feinberg
Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13026-31.
2004: David A Garber; Guido Silvestri; Mark B Feinberg
Prospects for an AIDS vaccine: three big questions, no easy answers.
The Lancet infectious diseases 2004;4(7):397-413.
2004: Roland R Regoes; Rustom Antia; David A Garber; Guido Silvestri; Mark B Feinberg; Silvija I Staprans
Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection.
Journal of virology 2004;78(9):4866-75.
2004: David A Garber; Guido Silvestri; Ashley P Barry; Andrew Fedanov; Natalia Kozyr; Harold M McClure; David C Montefiori; Christian P Larsen; John D Altman; Silvija I Staprans; Mark B Feinberg
Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication.
The Journal of clinical investigation 2004;113(6):836-45.
2004: Mirko Paiardini; Barbara Cervasi; Domenico Galati; Sabrina Dominici; Helmut Albrecht; Alessandra Sfacteria; Mauro Magnani; Guido Silvestri; Giuseppe Piedimonte
Early correction of cell cycle perturbations predicts the immunological response to therapy in HIV-infected patients.
AIDS (London, England) 2004;18(3):393-402.
2004: Alagarraju Muthukumar; Aneta Wozniakowski; Marie-Claire E Gauduin; Mirko Paiardini; Harold M McClure; R Paul Johnson; Guido Silvestri; Donald L Sodora
Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression.
Blood 2004;103(3):973-9.
2004: Mirko Paiardini; Barbara Cervasi; Richard Dunham; Beth Sumpter; Henry Radziewicz; Guido Silvestri
Cell-cycle dysregulation in the immunopathogenesis of AIDS.
Immunologic research 2004;29(1-3):253-68.
2003: Domenico Galati; Mirko Paiardini; Barbara Cervasi; Helmut Albrecht; Marialuisa Bocchino; Andrea Costantini; Maria Montroni; Mauro Magnani; Giuseppe Piedimonte; Guido Silvestri
Specific changes in the posttranslational regulation of nucleolin in lymphocytes from patients infected with human immunodeficiency virus.
The Journal of infectious diseases 2003;188(10):1483-91.
2003: Ann Chahroudi; Guido Silvestri; Mark B Feinberg
Measuring T cell-mediated cytotoxicity using fluorogenic caspase substrates.
Methods (San Diego, Calif.) 2003;31(2):120-6.
2003: Guido Silvestri; Mark B Feinberg
Turnover of lymphocytes and conceptual paradigms in HIV infection.
The Journal of clinical investigation 2003;112(6):821-4.
2003: Andrea Costantini; Stefania Mancini; S Giuliodoro; Luca Butini; Christina M Regnery; Guido Silvestri; Maria Montroni
Effects of cryopreservation on lymphocyte immunophenotype and function.
Journal of immunological methods 2003;278(1-2):145-55.
2003: Guido Silvestri; Donald L Sodora; Richard A Koup; Mirko Paiardini; Shawn P O'Neil; Harold M McClure; Silvija I Staprans; Mark B Feinberg
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.
Immunity 2003;18(3):441-52.
2002: Alessandra Fraternale; Anna Casabianca; Chiara Orlandi; Laura Chiarantini; Giorgio Brandi; Guido Silvestri; Mauro Magnani
Repeated cycles of alternate administration of fludarabine and Zidovudine plus Didanosine inhibits murine AIDS and reduces proviral DNA content in lymph nodes to undetectable levels.
Virology 2002;302(2):354-62.
2002: Domenico Galati; Marialuisa Bocchino; Mirko Paiardini; Barbara Cervasi; Guido Silvestri; Giuseppe Piedimonte
Cell cycle dysregulation during HIV infection: perspectives of a target based therapy.
Current drug targets. Immune, endocrine and metabolic disorders 2002;2(1):53-61.
2002: Mark B Feinberg; Guido Silvestri
T(S) cells and immune tolerance induction: a regulatory renaissance?
Nature immunology 2002;3(3):215-7.
2002: Luzheng Liu; Ann Chahroudi; Guido Silvestri; Mary E Wernett; William J Kaiser; Jeffrey T Safrit; Akira Komoriya; John D Altman; Beverly Z Packard; Mark B Feinberg
Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates.
Nature medicine 2002;8(2):185-9.
2001: Mirko Paiardini; Domenico Galati; Barbara Cervasi; G Cannavo; Luca Galluzzi; Maria Montroni; Denise Guetard; Mauro Magnani; Giuseppe Piedimonte; Guido Silvestri
Exogenous interleukin-2 administration corrects the cell cycle perturbation of lymphocytes from human immunodeficiency virus-infected individuals.
Journal of virology 2001;75(22):10843-55.
2001: C Muñoz-Calleja; Andrea Costantini; Guido Silvestri; Luca Butini; Christina M Regnery; Stefania Mancini; Maria Montroni
Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations.
AIDS (London, England) 2001;15(14):1887-90.
2001: G Cannavo'; Mirko Paiardini; Domenico Galati; Barbara Cervasi; Maria Montroni; Gionata De Vico; Denise Guetard; Marialuisa Bocchino; Isa Picerno; Mauro Magnani; Guido Silvestri; Giuseppe Piedimonte
Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis.
Blood 2001;97(6):1756-64.
2000: Donald L Sodora; Daniel C Douek; Guido Silvestri; Lisa Montgomery; M Rosenzweig; T Igarashi; B Bernacky; R Paul Johnson; Mark B Feinberg; Malcolm Martin; Richard A Koup
Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys.
European journal of immunology 2000;30(4):1145-53.
1999: Giuseppe Piedimonte; D Corsi; Mirko Paiardini; Giuseppe Cannavò; Riccardo Ientile; Isa Picerno; Maria Montroni; Guido Silvestri; Mauro Magnani
Unscheduled cyclin B expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients.
AIDS (London, England) 1999;13(10):1159-64.
1998: Guido Silvestri; C Munoz-Calleja; Patrizia Bagnarelli; Giuseppe Piedimonte; Massimo Clementi; Maria Montroni
Early increase of CD4+ CD45RA+ and CD4+ CD95- cells with conserved repertoire induced by anti-retroviral therapy in HIV-infected patients.
Clinical and experimental immunology 1998;111(1):3-11.
1997: Giuseppe Piedimonte; Denise Guetard; Mauro Magnani; D Corsi; Isa Picerno; Pasquale Spataro; L Kramer; Maria Montroni; Guido Silvestri; J F Torres Roca; Luc Montagnier
Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus.
The Journal of infectious diseases 1997;176(3):655-64.
1997: Guido Silvestri; C Munoz; Luca Butini; Patrizia Bagnarelli; Maria Montroni
Changes in CD8 cell subpopulations induced by antiretroviral therapy in human immunodeficiency virus infected patients.
Viral immunology 1997;10(4):207-12.
1996: Guido Silvestri; H Soudeyns; J Samson; F Denis; N Lapointe; R P Sékaly
T-cell receptor V beta-specific expansions in children from HIV-infected mothers.
AIDS (London, England) 1996;10(5):549-51.
1993: Maria Montroni; Guido Silvestri; Luca Butini; C Regnery; C Bartocci; F Buffarini; G Danieli
p24 antigenaemia and clinical response to zidovudine therapy.
AIDS (London, England) 1993;7(3):434-5.
1993: Giuseppe Piedimonte; Maria Montroni; Guido Silvestri; L Silvotti; A Donatini; L Rossi; Angelo F Borghetti; M Magnani
Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro.
Archives of virology 1993;130(3-4):463-9.
1992: Maria Montroni; Guido Silvestri; Luca Butini; C Bartocci; C Regnery; G Danieli
p24 antigenaemia as a predictor of good immunological responsiveness to zidovudine therapy in asymptomatic HIV infection.
AIDS (London, England) 1992;6(3):338-9.