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Rafi Ahmed

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TOP 3
J Scott Hale; Smita S Iyer; Donald R Latner; Ata Ur Rasheed Mohammed; Tuoqi Wu; Lilin Ye; Ben Youngblood; Rama S Akondy; Rafi Ahmed
Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.
Koichi Araki; Rafi Ahmed
AMPK: a metabolic switch for CD8+ T-cell memory.
Christopher Chiu; Gui-Mei Li; Megan McCausland; Patrick C Wilson; Jens Wrammert; Rafi Ahmed
Cross-reactive humoral responses to influenza and their implications for a universal vaccine.

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All Publications

2013: J Scott Hale; Smita S Iyer; Donald R Latner; Ata Ur Rasheed Mohammed; Tuoqi Wu; Lilin Ye; Ben Youngblood; Rama S Akondy; Rafi Ahmed
Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.
Immunity 2013;38(4):805-17.
2013: Koichi Araki; Rafi Ahmed
AMPK: a metabolic switch for CD8+ T-cell memory.
European journal of immunology 2013;43(4):878-81.
2013: Christopher Chiu; Gui-Mei Li; Megan McCausland; Patrick C Wilson; Jens Wrammert; Rafi Ahmed
Cross-reactive humoral responses to influenza and their implications for a universal vaccine.
Annals of the New York Academy of Sciences 2013;1283(1):13-21.
2013: Christopher B Brooke; William L Ince; Patrick C Wilson; Jens Wrammert; Rafi Ahmed; Jack R Bennink; Jonathan W Yewdell
Most influenza a virions fail to express at least one essential viral protein.
Journal of virology 2013;87(6):3155-62.
2013: Wendy G Tan; Erin E West; Andreas Wieland; Michael J Zilliox; Dan H Barouch; Hyun-Tak Jin; M Juliana McElrath; Pablo Penaloza-MacMaster; Rafi Ahmed
Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors.
Journal of virology 2013;87(3):1359-72.
2013: Srilatha Edupuganti; Rachel Barwick Eidex; Harry L Keyserling; Robert S Lanciotti; Harvey B Lipman; Mark MULLIGAN; Walter Orenstein; Yi Pan; Troy D Querec; Dirk Teuwen; Rafi Ahmed; Rama S Akondy; Alan Barrett; Martin S Cetron; Carlos del Rio
A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity.
The American journal of tropical medicine and hygiene 2013;88(1):172-7.
2012: Xiaojin Xu; Lilin Ye; Koichi Araki; Rafi Ahmed
mTOR, linking metabolism and immunity.
Seminars in immunology 2012;24(6):429-35.
2012: Conrad P Quinn; David M Robinson; Thomas L Rudge; Carol L Sabourin; Jarad Schiffer; Vera A Semenova; Jens Wrammert; Rafi Ahmed; Roy E Barnewall; April Brys; James E Estep; Robert E Hunt; Chris C Ibegbu; Denyse Levesque; Han Li; Nina Marano; Heather J Mayfield; Robert S Mittler; Nancy A Niemuth; Brian D Plikaytis
A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques.
Clinical and vaccine immunology : CVI 2012;19(11):1730-45.
2012: Dennis R Burton; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Rafi Ahmed; Dan H Barouch; Richard Wyatt
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe 2012;12(4):396-407.
2012: Hye Suk Yoon; Wendy Zinzow-Kramer; Rafi Ahmed; Royce Butler; Carl W Davis; Dimitrios G Koutsonanos; Parimal Majumder; Christopher D Scharer; Ioanna Skountzou; Jeremy M Boss
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2393-403.
2012: Philip L F Johnson; Beth F Kochin; Rafi Ahmed; Rustom Antia
How do antigenically varying pathogens avoid cross-reactive responses to invariant antigens?
Proceedings. Biological sciences / The Royal Society 2012;279(1739):2777-85.
2012: Mark B Feinberg; Rafi Ahmed
Born this way? Understanding the immunological basis of effective HIV control.
Nature immunology 2012;13(7):632-4.
2012: Tuoqi Wu; Lilin Ye; Koichi Araki; Carl W Davis; J Scott Hale; Andreas Wieland; Rafi Ahmed
Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9965-70.
2012: Gui-Mei Li; Megan McCausland; Aneesh K Mehta; Mark MULLIGAN; Xinyan Qu; Patrick C Wilson; Jens Wrammert; Jonathan W Yewdell; Nai-Ying Zheng; Sarah F Andrews; Christopher Chiu; Suman Das; Srilatha Edupuganti; Min Huang; Jane-Hwei Lee; Rafi Ahmed
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):9047-52.
2012: W M Zinzow-Kramer; Rafi Ahmed; R Butler; Brian D Evavold; Alyssa B Long; A-U-R Mohammed; K M Rosenthal; Ioanna Skountzou; B A Youngblood; Jeremy M Boss
CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments.
Genes and immunity 2012;13(4):299-310.
2012: Jian-Xin Lin; Chengyu Liu; Delong Liu; Yrina Rochman; Lu Wang; Mohammed Ata Ur Rasheed; Rafi Ahmed; Kairong Cui; Jianping He; Hyun-Tak Jin; Brian L Kelsall; Peng Li; Warren J Leonard
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.
Immunity 2012;36(4):586-99.
2012: Jens Wrammert; Sutee Yoksan; Rama S Akondy; Nasikarn Angkasekwinai; Anmol Chandele; Kulkanya Chokephaibulkit; Marcin Kwissa; Nattawat Onlamoon; Kovit Pattanapanyasat; Guey Chuen Perng; Korakot Polsrila; Bali Pulendran; Patrick C Wilson; Orasri Wittawatmongkol; Rafi Ahmed
Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans.
Journal of virology 2012;86(6):2911-8.
2012: Christopher D O'Donnell; Rafi Ahmed; Suman Das; Gui-Mei Li; Megan McCausland; Leatrice Vogel; Patrick C Wilson; Jens Wrammert; Amber Wright; Jonathan W Yewdell; Nai-Ying Zheng; Kanta Subbarao
Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice.
mBio 2012;3(3):.
2012: Ali H Ellebedy; Rafi Ahmed
Re-engaging cross-reactive memory B cells: the influenza puzzle.
Frontiers in immunology 2012;3():53.
2012: Ben Youngblood; E John Wherry; Rafi Ahmed
Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.
Current opinion in HIV and AIDS 2012;7(1):50-7.
2012: Smita S Iyer; Rafi Ahmed; Todd C Becker; Wendy G Tan; Janel Hart Chatraw; E John Wherry; Zoher F Kapasi
Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(1):77-84.
2011: Rachael D Aubert; Sang-Jun Ha; Arlene H Sharpe; Alice O Kamphorst; Vaiva Vezys; Lilin Ye; Daniel L Barber; Gordon J Freeman; Surojit Sarkar; Rafi Ahmed
Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(52):21182-7.
2011: Koichi Araki; Ali H Ellebedy; Rafi Ahmed
TOR in the immune system.
Current opinion in cell biology 2011;23(6):707-15.
2011: Rafi Ahmed; Bali Pulendran
Learning vaccinology from viral infections.
The Journal of experimental medicine 2011;208(12):2347-9.
2011: Maya F Kotturi; William W Kwok; Bjoern Peters; Rafi Ahmed; Rama S Akondy; Cecilia Lindestam Arlehamn; Michael J Buchmeier; Eddie A James; Ravi V Kolla; John Sidney; Justine A Swann; Alessandro Sette
Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.
Journal of virology 2011;85(22):11770-80.
2011: Bruce D Walker; Rafi Ahmed; Stanley Plotkin
Moving ahead an HIV vaccine: use both arms to beat HIV.
Nature medicine 2011;17(10):1194-5.
2011: Ben Youngblood; Rama S Akondy; James W Austin; Jeremy M Boss; Jaikumar Duraiswamy; Sang-Jun Ha; Peiyuan Lu; Kenneth J Oestreich; James L Riley; Zhengyu Wei; Erin E West; Rafi Ahmed
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Immunity 2011;35(3):400-12.
2011: Stephen C De Rosa; Allan deCamp; Barney S Graham; Yunda Huang; Spyros A Kalams; Chuen-Yen Lau; M Juliana McElrath; Cecilia Morgan; Gary Nabel; Evan P Thomas; Georgia D Tomaras; Rafi Ahmed; Rama Akondy; John Bui
HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3391-401.
2011: Erin E West; Ben Youngblood; Gabriela Alexe; Koichi Araki; Silvia Calpe; Gordon J Freeman; W Nicholas Haining; Hyun-Tak Jin; Bogumila T Konieczny; Wendy G Tan; Cox Terhorst; Rafi Ahmed
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.
Immunity 2011;35(2):285-98.
2011: Vaiva Vezys; Daniel L Barber; Gordon J Freeman; Sang-Jun Ha; Bogumila T Konieczny; Robert S Mittler; Pablo Penaloza-MacMaster; Rafi Ahmed
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1634-42.
2011: Helder I Nakaya; Luigi Racioppi; Kanta Subbarao; Jens Wrammert; Alan Aderem; Rafi Ahmed; Rivka Elbein; W Nicholas Haining; Vibhu Kanchan; Sudhir P Kasturi; Nooruddin Khan; Kenneth E Kokko; Eva K Lee; Gui-Mei Li; Shuzhao Li; Stephanie Marie-Kunze; Megan McCausland; Anthony R Means; Aneesh K Mehta; Bali Pulendran
Systems biology of vaccination for seasonal influenza in humans.
Nature immunology 2011;12(8):786-95.
2011: Pablo Penaloza-MacMaster; Hideo Yagita; Ata Ur Rasheed; Bruce R Blazar; Smita S Iyer; Rafi Ahmed
Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice.
Journal of virology 2011;85(13):6168-74.
2011: Bali Pulendran; Rafi Ahmed
Immunological mechanisms of vaccination.
Nature immunology 2011;12(6):509-17.
2011: Judith N Mandl; Rama Akondy; Benton Lawson; Natalia Kozyr; Silvija I Staprans; Rafi Ahmed; Mark B Feinberg
Distinctive TLR7 signaling, type I IFN production, and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6406-16.
2011: Philip L F Johnson; Beth F Kochin; Megan S McAfee; Ingunn M Stromnes; Roland R Regoes; Rafi Ahmed; Joseph N Blattman; Rustom Antia
Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections.
Journal of virology 2011;85(11):5565-70.
2011: Sariah J Allen; Pedram Hamrah; David Gate; Kevin Mott; Dimosthenis Mantopoulos; Lixin Zheng; Terrence Town; Clinton Jones; Ulrich H von Andrian; Gordon J Freeman; Arlene H Sharpe; Lbachir BenMohamed; Rafi Ahmed; Steven L Wechsler; Homayon Ghiasi
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Journal of virology 2011;85(9):4184-97.
2011: Jaikumar Duraiswamy; Chris C Ibegbu; David Masopust; Joseph D Miller; Koichi Araki; Gregory H Doho; Pramila Tata; Satish Gupta; Michael J Zilliox; Helder I Nakaya; Bali Pulendran; W Nicholas Haining; Gordon J Freeman; Rafi Ahmed
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4200-12.
2011: A P Turner; V O Shaffer; Koichi Araki; C Martens; P L Turner; Shivaprakash Gangappa; Mandy L Ford; Rafi Ahmed; Allan D Kirk; Christian P Larsen
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(3):613-8.
2011: George A Punkosdy; Melissa Blain; Deborah D Glass; Mary M Lozano; Leigh O'Mara; Jaquelin P Dudley; Rafi Ahmed; Ethan M Shevach
Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3677-82.
2011: Rafi Ahmed; Rama S Akondy
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines.
Immunology and cell biology 2011;89(3):340-5.
2011: Anmol Chandele; Paushali Mukerjee; Gobardhan Das; Rafi Ahmed; Virander S Chauhan
Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii.
Immunology 2011;132(2):273-86.
2011: Jens Wrammert; Dimitrios Koutsonanos; Gui-Mei Li; Srilatha Edupuganti; Jianhua Sui; Michael Morrissey; Megan McCausland; Ioanna Skountzou; Mady Hornig; W Ian Lipkin; Aneesh Mehta; Behzad Razavi; Carlos Del Rio; Nai-Ying Zheng; Jane-Hwei Lee; Min Huang; Zahida Ali; Kaval Kaur; Sarah Andrews; Rama Rao Amara; Youliang Wang; Suman Das; Christopher David O'Donnell; Jon W Yewdell; Kanta Subbarao; Wayne A Marasco; Mark MULLIGAN; Richard W Compans; Rafi Ahmed; Patrick C Wilson
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection.
The Journal of experimental medicine 2011;208(1):181-93.
2011: Hyun-Tak Jin; Rafi Ahmed; Taku Okazaki
Role of PD-1 in regulating T-cell immunity.
Current topics in microbiology and immunology 2011;350():17-37.
2010: Federica Sallusto; Antonio Lanzavecchia; Koichi Araki; Rafi Ahmed
From vaccines to memory and back.
Immunity 2010;33(4):451-63.
2010: Koichi Araki; Shivaprakash Gangappa; Dirck L Dillehay; Barry T Rouse; Christian P Larsen; Rafi Ahmed
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.
The Journal of experimental medicine 2010;207(11):2355-67.
2010: Ben Youngblood; Carl W Davis; Rafi Ahmed
Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.
International immunology 2010;22(10):797-803.
2010: Daniel K Choo; Kaja Murali-Krishna; Rustom Anita; Rafi Ahmed
Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3436-44.
2010: Hyun-Tak Jin; Ana C Anderson; Wendy G Tan; Erin E West; Sang-Jun Ha; Koichi Araki; Gordon J Freeman; Vijay K Kuchroo; Rafi Ahmed
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14733-8.
2010: Scott N Mueller; William A Langley; Guimei Li; Adolfo García-Sastre; Richard J Webby; Rafi Ahmed
Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2182-90.
2010: Ivana R Ferrer; Maylene E Wagener; Jennifer M Robertson; Alexa P Turner; Koichi Araki; Rafi Ahmed; Allan D Kirk; Christian P Larsen; Mandy L Ford
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2004-8.
2010: Scott N Mueller; Vijay K Vanguri; Sang-Jun Ha; Erin E West; Mary E Keir; Jonathan N Glickman; Arlene H Sharpe; Rafi Ahmed
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.
The Journal of clinical investigation 2010;120(7):2508-15.
2010: Koichi Araki; Ben Youngblood; Rafi Ahmed
The role of mTOR in memory CD8 T-cell differentiation.
Immunological reviews 2010;235(1):234-43.
2010: Peter S Kim; Rafi Ahmed
Features of responding T cells in cancer and chronic infection.
Current opinion in immunology 2010;22(2):223-30.
2010: David Masopust; Daniel Choo; Vaiva Vezys; E John Wherry; Jaikumar Duraiswamy; Rama Akondy; Jun Wang; Kerry A Casey; Daniel L Barber; Kim S Kawamura; Kathryn A Fraser; Richard J Webby; Volker Brinkmann; Eugene C Butcher; Kenneth A Newell; Rafi Ahmed
Dynamic T cell migration program provides resident memory within intestinal epithelium.
The Journal of experimental medicine 2010;207(3):553-64.
2010: Scott N Mueller; William A Langley; Elena Carnero; Adolfo García-Sastre; Rafi Ahmed
Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses.
Journal of virology 2010;84(4):1847-55.
2010: Vandana Kalia; Surojit Sarkar; Shruti Subramaniam; W Nicholas Haining; Kendall A Smith; Rafi Ahmed
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.
Immunity 2010;32(1):91-103.
2010: Vandana Kalia; Surojit Sarkar; Rafi Ahmed
CD8 T-cell memory differentiation during acute and chronic viral infections.
Advances in experimental medicine and biology 2010;684():79-95.
2009: Rama S Akondy; Nathan D Monson; Joseph D Miller; Srilatha Edupuganti; Dirk Teuwen; Hong Wu; Farah Quyyumi; Seema Garg; John D Altman; Carlos Del Rio; Harry L Keyserling; Alexander Ploss; Charles M Rice; Walter A Orenstein; Mark MULLIGAN; Rafi Ahmed
The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7919-30.
2009: Pablo Penaloza-MacMaster; David Masopust; Rafi Ahmed
T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction.
Immunology 2009;128(2):164-71.
2009: Rafi Ahmed; Michael J Bevan; Steven L Reiner; Douglas T Fearon
The precursors of memory: models and controversies.
Nature reviews. Immunology 2009;9(9):662-8.
2009: Herbert W Virgin; E John Wherry; Rafi Ahmed
Redefining chronic viral infection.
Cell 2009;138(1):30-50.
2009: Koichi Araki; Alexandra P Turner; Virginia Oliva Shaffer; Shivaprakash Gangappa; Susanne A Keller; Martin F Bachmann; Christian P Larsen; Rafi Ahmed
mTOR regulates memory CD8 T-cell differentiation.
Nature 2009;460(7251):108-12.
2009: Scott N Mueller; Rafi Ahmed
High antigen levels are the cause of T cell exhaustion during chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8623-8.
2009: Joseph N Blattman; E John Wherry; Sang-Jun Ha; Robbert van der Most; Rafi Ahmed
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection.
Journal of virology 2009;83(9):4386-94.
2009: Qingsheng Li; Pamela J Skinner; Sang-Jun Ha; Lijie Duan; Teresa L Mattila; Aaron Hage; Cara White; Daniel L Barber; Leigh O'Mara; Peter J Southern; Cavan S Reilly; John V Carlis; Christopher J Miller; Rafi Ahmed; Ashley T Haase
Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection.
Science (New York, N.Y.) 2009;323(5922):1726-9.
2009: Vijayakumar Velu; Kehmia Titanji; Baogong Zhu; Sajid Husain; Annette Pladevega; Lilin Lai; Thomas H Vanderford; Lakshmi Chennareddi; Guido Silvestri; Gordon J Freeman; Rafi Ahmed; Rama Rao Amara
Enhancing SIV-specific immunity in vivo by PD-1 blockade.
Nature 2009;458(7235):206-10.
2009: Jens Wrammert; Joe Miller; Rama Akondy; Rafi Ahmed
Human immune memory to yellow fever and smallpox vaccination.
Journal of clinical immunology 2009;29(2):151-7.
2009: Jason K Whitmire; Mary S Asano; Susan M Kaech; Surojit Sarkar; Lynn G Hannum; Mark J Shlomchik; Rafi Ahmed
Requirement of B cells for generating CD4+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1868-76.
2009: Vaiva Vezys; Yates Andrew; Kerry A Casey; Gibson Lanier; Rafi Ahmed; Rustom Antia; David Masopust
Memory CD8 T-cell compartment grows in size with immunological experience.
Nature 2009;457(7226):196-9.
2009: Kenneth Smith; Lori Garman; Jens Wrammert; Nai-Ying Zheng; J Donald Capra; Rafi Ahmed; Patrick C Wilson
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen.
Nature protocols 2009;4(3):372-84.
2009: Troy D Querec; Rama S Akondy; Eva K Lee; Weiping Cao; Helder I Nakaya; Dirk Teuwen; Ali Pirani; Kim Gernert; Jiusheng Deng; Bruz Marzolf; Kathleen Kennedy; Haiyan Wu; Soumaya Bennouna; Herold Oluoch; Joseph Miller; Ricardo Z Vencio; Mark MULLIGAN; Alan Aderem; Rafi Ahmed; Bali Pulendran
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Nature immunology 2009;10(1):116-25.
2009: Nicole A Doria-Rose; Rachel M Klein; Maura M Manion; Sijy O'Dell; Adhuna Phogat; Bimal K Chakrabarti; Claire W Hallahan; Stephen A Migueles; Jens Wrammert; Rafi Ahmed; Martha Nason; Richard Wyatt; John R Mascola; Mark Connors
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies.
Journal of virology 2009;83(1):188-99.
2008: Kenneth J Oestreich; Hyesuk Yoon; Rafi Ahmed; Jeremy M Boss
NFATc1 regulates PD-1 expression upon T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4832-9.
2008: Channa R Jayasekera; Jason B Harris; Saruar Bhuiyan; Fahima Chowdhury; Ashraful I Khan; A S G Faruque; Regina C LaRocque; Edward T Ryan; Rafi Ahmed; Firdausi Qadri; Stephen B Calderwood
Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1.
The Journal of infectious diseases 2008;198(7):1055-61.
2008: Bali Pulendran; Joseph Miller; Troy D Querec; Rama Akondy; Nelson Moseley; Oscar Laur; John Glidewell; Nathan Monson; Tuofu Zhu; Haiying Zhu; Silvija I Staprans; David Lee; Margo A Brinton; Andrey A Perelygin; Claudia Vellozzi; Philip Brachman; Susan Lalor; Dirk Teuwen; Rachel B Eidex; Marty Cetron; Frances Priddy; Carlos del Rio; John D Altman; Rafi Ahmed
Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.
The Journal of infectious diseases 2008;198(4):500-7.
2008: Scott N Mueller; Rafi Ahmed
Lymphoid stroma in the initiation and control of immune responses.
Immunological reviews 2008;224():284-94.
2008: W Nicholas Haining; Benjamin L Ebert; Aravind Subrmanian; E John Wherry; Quentin Eichbaum; John W Evans; Raymond Mak; Stephen Rivoli; Jennifer Pretz; Jill Angelosanto; John S Smutko; Bruce D Walker; Susan M Kaech; Rafi Ahmed; Lee M Nadler; Todd R Golub
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1859-68.
2008: Sang-Jun Ha; Erin E West; Koichi Araki; Kendall A Smith; Rafi Ahmed
Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.
Immunological reviews 2008;223():317-33.
2008: Henry Radziewicz; Holly L Hanson; Rafi Ahmed; Arash Grakoui
Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application?
Gastroenterology 2008;134(7):2168-71.
2008: Jens Wrammert; Kenneth Smith; Joe Miller; William A Langley; Kenneth E Kokko; Christian P Larsen; Nai-Ying Zheng; Israel Mays; Lori Garman; Christina Helms; Judith James; Gillian M Air; J Donald Capra; Rafi Ahmed; Patrick C Wilson
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.
Nature 2008;453(7195):667-71.
2008: Jens Wrammert; Rafi Ahmed
Maintenance of serological memory.
Biological chemistry 2008;389(5):537-9.
2008: Joseph D Miller; Robbert van der Most; Rama S Akondy; John T Glidewell; Sophia Albott; David Masopust; Kaja Murali-Krishna; Patryce L Mahar; Srilatha Edupuganti; Susan Lalor; Stephanie Germon; Carlos del Rio; Mark MULLIGAN; Silvija I Staprans; John D Altman; Mark B Feinberg; Rafi Ahmed
Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
Immunity 2008;28(5):710-22.
2008: Janel Hart Chatraw; E John Wherry; Rafi Ahmed; Zoher F Kapasi
Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors.
The Journal of nutrition 2008;138(4):806-12.
2008: Shivaprakash Gangappa; Kenneth E Kokko; Lisa M Carlson; Tania Gourley; Kenneth A Newell; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Immune responsiveness and protective immunity after transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(4):293-303.
2008: Sang-Jun Ha; Scott N Mueller; E John Wherry; Daniel L Barber; Rachael D Aubert; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection.
The Journal of experimental medicine 2008;205(3):543-55.
2008: Surojit Sarkar; Vandana Kalia; W Nicholas Haining; Bogumila T Konieczny; Shruti Subramaniam; Rafi Ahmed
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.
The Journal of experimental medicine 2008;205(3):625-40.
2008: Di Qu; Gibson Lanier; zhenghong yuan; Yu-Mei Wen; Colin R Howard; Rafi Ahmed
Localization of CD8+ cells specific for hepatitis B virus surface protein in the liver of immunized mice.
Journal of medical virology 2008;80(2):225-32.
2008: Vandana Kalia; Surojit Sarkar; Rafi Ahmed
Fine-tuning CD4+ central memory T cell heterogeneity by strength of stimulation.
European journal of immunology 2008;38(1):15-9.
2007: Surojit Sarkar; Volker Teichgräber; Vandana Kalia; Antonio Polley; David Masopust; Laurie E Harrington; Rafi Ahmed; E John Wherry
Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6704-14.
2007: Ritu Aneja; Vandana Kalia; Rafi Ahmed; Harish C Joshi
Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection.
Molecular cancer therapeutics 2007;6(11):2891-9.
2007: David Masopust; Vaiva Vezys; E John Wherry; Rafi Ahmed
A brief history of CD8 T cells.
European journal of immunology 2007;37 Suppl 1():S103-10.
2007: Rafi Ahmed; Michael B A Oldstone; Peter Palese
Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic.
Nature immunology 2007;8(11):1188-93.
2007: E John Wherry; Sang-Jun Ha; Susan M Kaech; W Nicholas Haining; Surojit Sarkar; Vandana Kalia; Shruti Subramaniam; Joseph N Blattman; Daniel L Barber; Rafi Ahmed
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
Immunity 2007;27(4):670-84.
2007: Carolyn M Constantin; David Masopust; Tania Gourley; Jason M Grayson; Ora L Strickland; Rafi Ahmed; Elizabeth A Bonney
Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4383-9.
2007: Benyue Zhang; Charles H Maris; Juergen Foell; Jason K Whitmire; Liguo Niu; Jing Song; Byoung S Kwon; Anthony T Vella; Rafi Ahmed; Joshy Jacob; Robert S Mittler
Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.
The Journal of clinical investigation 2007;117(10):3029-41.
2007: Kevin L Karem; Mary Reynolds; Christine Hughes; Zachary H Braden; Pragati Nigam; Shane Crotty; John Glidewell; Rafi Ahmed; Rama Rao Amara; Inger K Damon
Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection.
Clinical and vaccine immunology : CVI 2007;14(10):1318-27.
2007: Scott N Mueller; Mehrdad Matloubian; Daniel M Clemens; Arlene H Sharpe; Gordon J Freeman; Shivaprakash Gangappa; Christian P Larsen; Rafi Ahmed
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15430-5.
2007: Brent Howard Koehn; Matthew A Williams; Keshawna Borom; Shivaprakash Gangappa; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2616-26.
2007: Scott N Mueller; Karoline A Hosiawa-Meagher; Bogumila T Konieczny; Brandon M Sullivan; Martin F Bachmann; Richard M Locksley; Rafi Ahmed; Mehrdad Matloubian
Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
Science (New York, N.Y.) 2007;317(5838):670-4.
2007: Vijayakumar Velu; Sunil Kannanganat; Chris C Ibegbu; Lakshmi Chennareddi; Francios VILLINGER; Gordon J Freeman; Rafi Ahmed; Rama Rao Amara
Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination.
Journal of virology 2007;81(11):5819-28.
2007: D Huw Davies; Douglas M Molina; Jens Wrammert; Joe Miller; Siddiqua Hirst; Yunxiang Mu; Jozelyn Pablo; Berkay Unal; Rie Nakajima-Sasaki; Xiaowu Liang; Shane Crotty; Kevin L Karem; Inger K Damon; Rafi Ahmed; Luis P Villarreal; Philip L Felgner
Proteome-wide analysis of the serological response to vaccinia and smallpox.
Proteomics 2007;7(10):1678-86.
2007: Elsa M Laughlin; Joseph D Miller; Eddie James; Dimitri Fillos; Chris C Ibegbu; Robert S Mittler; Rama Akondy; William Kwok; Rafi Ahmed; Gerald Nepom
Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.
Infection and immunity 2007;75(4):1852-60.
2007: Arlene H Sharpe; E John Wherry; Rafi Ahmed; Gordon J Freeman
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.
Nature immunology 2007;8(3):239-45.
2007: Henry Radziewicz; Chris C Ibegbu; Marina L Fernandez; Kimberly A Workowski; Kamil Obideen; Mohammad Wehbi; Holly L Hanson; James P Steinberg; David Masopust; E John Wherry; John D Altman; Barry T Rouse; Gordon J Freeman; Rafi Ahmed; Arash Grakoui
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.
Journal of virology 2007;81(6):2545-53.
2007: David Masopust; Kaja Murali-Krishna; Rafi Ahmed
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought.
Journal of virology 2007;81(4):2002-11.
2007: Roland R Regoes; Daniel L Barber; Rafi Ahmed; Rustom Antia
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1599-603.
2007: Yates Andrew; Frederik Graw; Daniel L Barber; Rafi Ahmed; Roland R Regoes; Rustom Antia
Revisiting estimates of CTL killing rates in vivo.
PloS one 2007;2(12):e1301.
2006: Shane Crotty; Megan M McCausland; Rachael D Aubert; E John Wherry; Rafi Ahmed
Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease.
Blood 2006;108(9):3085-93.
2006: Gordon J Freeman; E John Wherry; Rafi Ahmed; Arlene H Sharpe
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade.
The Journal of experimental medicine 2006;203(10):2223-7.
2006: Vaiva Vezys; David Masopust; Christopher C Kemball; Daniel L Barber; Leigh A O'Mara; Christian P Larsen; Thomas C Pearson; Rafi Ahmed; Aron E Lukacher
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
The Journal of experimental medicine 2006;203(10):2263-9.
2006: Arash Grakoui; E John Wherry; Holly L Hanson; Christopher Walker; Rafi Ahmed
Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway.
Journal of hepatology 2006;45(4):468-72.
2006: E John Wherry; Cheryl L Day; Rika Draenert; Joseph D Miller; Photini Kiepiela; Tonia Woodberry; Christian Brander; Marylyn M Addo; Paul Klenerman; Rafi Ahmed; Bruce D Walker
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Virology 2006;353(2):366-73.
2006: Cheryl L Day; Daniel E Kaufmann; Photini Kiepiela; Julia A Brown; Eshia Stephany Moodley-Govender; Sharon Reddy; Elizabeth W Mackey; Joseph D Miller; Alasdair Leslie; Chantal DePierres; Zenele Mncube; Jaikumar Duraiswamy; Baogong Zhu; Quentin Eichbaum; Marcus Altfeld; E John Wherry; Hoosen M Coovadia; Philip J R Goulder; Paul Klenerman; Rafi Ahmed; Gordon J Freeman; Bruce D Walker
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature 2006;443(7109):350-4.
2006: David Masopust; Sang-Jun Ha; Vaiva Vezys; Rafi Ahmed
Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):831-9.
2006: Vitaly V Ganusov; Sergei S Pilyugin; Rafi Ahmed; Rustom Antia
How does cross-reactive stimulation affect the longevity of CD8+ T cell memory?
PLoS computational biology 2006;2(6):e55.
2006: Vandana Kalia; Surojit Sarkar; Tania S Gourley; Barry T Rouse; Rafi Ahmed
Differentiation of memory B and T cells.
Current opinion in immunology 2006;18(3):255-64.
2006: Ellen N Kersh; David R Fitzpatrick; Kaja Murali-Krishna; John Shires; Samuel H Speck; Jeremy M Boss; Rafi Ahmed
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4083-93.
2006: Brent Howard Koehn; Shivaprakash Gangappa; Joeseph D Miller; Rafi Ahmed; Christian P Larsen
Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2691-6.
2006: Bali Pulendran; Rafi Ahmed
Translating innate immunity into immunological memory: implications for vaccine development.
Cell 2006;124(4):849-63.
2006: Troy D Querec; Soumaya Bennouna; Sefik Alkan; Yasmina Laouar; Keith Gorden; Richard Flavell; Shizuo Akira; Rafi Ahmed; Bali Pulendran
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.
The Journal of experimental medicine 2006;203(2):413-24.
2006: David Masopust; Vaiva Vezys; E John Wherry; Daniel L Barber; Rafi Ahmed
Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2079-83.
2006: Daniel L Barber; E John Wherry; David Masopust; Baogong Zhu; James P Allison; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Restoring function in exhausted CD8 T cells during chronic viral infection.
Nature 2006;439(7077):682-7.
2005: Andrew M Intlekofer; Naofumi Takemoto; E John Wherry; Sarah A Longworth; John T Northrup; Vikram R Palanivel; Alan C Mullen; Christopher R Gasink; Susan M Kaech; Joseph D Miller; Laurent Gapin; Kenneth Ryan; Andreas P Russ; Tullia Lindsten; Jordan S Orange; Ananda W Goldrath; Rafi Ahmed; Steven L Reiner
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.
Nature immunology 2005;6(12):1236-44.
2005: Zhu-Nan Li; Scott N Mueller; Ling Ye; Zhigao Bu; Chinglai Yang; Rafi Ahmed; David A Steinhauer
Chimeric influenza virus hemagglutinin proteins containing large domains of the Bacillus anthracis protective antigen: protein characterization, incorporation into infectious influenza viruses, and antigenicity.
Journal of virology 2005;79(15):10003-12.
2005: E John Wherry; Joseph N Blattman; Rafi Ahmed
Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination.
Journal of virology 2005;79(14):8960-8.
2005: J D Miller; David Masopust; E John Wherry; Susan M Kaech; Guido Silvestri; Rafi Ahmed
Differentiation of CD8 T cells in response to acute and chronic viral infections: implications for HIV vaccine development.
Current drug targets. Infectious disorders 2005;5(2):121-9.
2005: Peter M Manders; Patricia J Hunter; Aino I Telaranta; James M Carr; Jennifer L Marshall; Marlene Carrasco; Yusuke Murakami; Michael J Palmowski; Vincenzo Cerundolo; Susan M Kaech; Rafi Ahmed; Douglas T Fearon
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7418-25.
2005: Manisha Gupta; Patricia Greer; Siddhartha Mahanty; Wun-Ju Shieh; Sherif R Zaki; Rafi Ahmed; Pierre E Rollin
CD8-mediated protection against Ebola virus infection is perforin dependent.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4198-202.
2005: Scott Kitchen; Jason K Whitmire; Nicole R Jones; Zoran Galic; Christina Kitchen; Rafi Ahmed; Jerome A Zack
The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3794-9.
2005: Vitaly V Ganusov; Sergei S Pilyugin; Rob J De Boer; Kaja Murali-Krishna; Rafi Ahmed; Rustom Antia
Quantifying cell turnover using CFSE data.
Journal of immunological methods 2005;298(1-2):183-200.
2005: Rustom Antia; Vitaly V Ganusov; Rafi Ahmed
The role of models in understanding CD8+ T-cell memory.
Nature reviews. Immunology 2005;5(2):101-11.
2005: Todd C Becker; Shana M Coley; E John Wherry; Rafi Ahmed
Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1269-73.
2005: Zoher F Kapasi; Michael L McRae; Rafi Ahmed
Suppression of viral specific primary T-cell response following intense physical exercise in young but not old mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(2):663-71.
2004: E John Wherry; Daniel L Barber; Susan M Kaech; Joseph N Blattman; Rafi Ahmed
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):16004-9.
2004: Laurent Sabbagh; Susan M Kaech; Martin Bourbonnière; Minna Woo; Luchino Y Cohen; Elias K Haddad; Nathalie Labrecque; Rafi Ahmed; Rafick-Pierre Sékaly
The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5425-33.
2004: Tania S Gourley; E John Wherry; David Masopust; Rafi Ahmed
Generation and maintenance of immunological memory.
Seminars in immunology 2004;16(5):323-33.
2004: Donald R Latner; Susan M Kaech; Rafi Ahmed
Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells.
Journal of virology 2004;78(20):10953-9.
2004: Conrad P Quinn; Peter M Dull; Vera A Semenova; Han Li; Shane Crotty; Thomas H Taylor; Evelene Steward-Clark; Karen Stamey; Daniel S Schmidt; Kelly Wallace Stinson; Alison E Freeman; Cheryl M Elie; Sandra K Martin; Carolyn Greene; Rachael D Aubert; John Glidewell; Bradley A Perkins; Rafi Ahmed; David S Stephens
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax.
The Journal of infectious diseases 2004;190(7):1228-36.
2004: E John Wherry; Rafi Ahmed
Memory CD8 T-cell differentiation during viral infection.
Journal of virology 2004;78(11):5535-45.
2004: Shane Crotty; Rafi Ahmed
Immunological memory in humans.
Seminars in immunology 2004;16(3):197-203.
2004: Zhengqi Wu; Margaret Roberts; Melissa Porter; Fabianne Walker; E John Wherry; John Kelly; Massimo Gadina; Elisabeth M Silva; George A DosReis; Marcela F Lopes; John O'Shea; Warren J Leonard; Rafi Ahmed; Richard Siegel
Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6313-23.
2004: Anna Derjuga; Tania S Gourley; Teresa M Holm; Hong-Qiang Heng; Ramesh A Shivdasani; Rafi Ahmed; Nancy C Andrews; Volker Blank
Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
Molecular and cellular biology 2004;24(8):3286-94.
2004: David Masopust; Susan M Kaech; E John Wherry; Rafi Ahmed
The role of programming in memory T-cell development.
Current opinion in immunology 2004;16(2):217-25.
2004: Shane Crotty; Rachael D Aubert; John Glidewell; Rafi Ahmed
Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system.
Journal of immunological methods 2004;286(1-2):111-22.
2004: Manas Mandal; Kim S Kawamura; E John Wherry; Rafi Ahmed; Kyung-Dall Lee
Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity.
Molecular pharmaceutics 2004;1(1):2-8.
2004: David Masopust; Rafi Ahmed
Reflections on CD8 T-cell activation and memory.
Immunologic research 2004;29(1-3):151-60.
2004: Manisha Gupta; Siddhartha Mahanty; Patricia Greer; Jonathan S Towner; Wun-Ju Shieh; Sherif R Zaki; Rafi Ahmed; Pierre E Rollin
Persistent infection with ebola virus under conditions of partial immunity.
Journal of virology 2004;78(2):958-67.
2003: Mandy L Ford; Thandi M Onami; Anne I Sperling; Rafi Ahmed; Brian D Evavold
CD43 modulates severity and onset of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6527-33.
2003: Susan M Kaech; Joyce T Tan; E John Wherry; Bogumila T Konieczny; Charles D Surh; Rafi Ahmed
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.
Nature immunology 2003;4(12):1191-8.
2003: Sergei S Pilyugin; Vitaly V Ganusov; Kaja Murali-Krishna; Rafi Ahmed; Rustom Antia
The rescaling method for quantifying the turnover of cell populations.
Journal of theoretical biology 2003;225(2):275-83.
2003: Shane Crotty; Philip L Felgner; Huw Davies; John Glidewell; Luis P Villarreal; Rafi Ahmed
Cutting edge: long-term B cell memory in humans after smallpox vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):4969-73.
2003: Robbert van der Most; Kaja Murali-Krishna; J Gibson Lanier; E John Wherry; Maryann T Puglielli; Joseph N Blattman; Alessandro Sette; Rafi Ahmed
Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation.
Virology 2003;315(1):93-102.
2003: Robert A Seder; Rafi Ahmed
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation.
Nature immunology 2003;4(9):835-42.
2003: Junmei Wan; Denis Martinvalet; X Ji; C Lois; S M Kaech; Ulrich H von Andrian; Judy Lieberman; Rafi Ahmed; N Manjunath
The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes.
Immunology 2003;110(1):10-7.
2003: Siddhartha Mahanty; Manisha Gupta; Jason Paragas; Mike Bray; Rafi Ahmed; Pierre E Rollin
Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection.
Virology 2003;312(2):415-24.
2003: Daniel L Barber; E John Wherry; Rafi Ahmed
Cutting edge: rapid in vivo killing by memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):27-31.
2003: Andrew B Adams; Matthew A Williams; Thomas R Jones; Nozomu Shirasugi; Megan M Durham; Susan M Kaech; E John Wherry; Thandi M Onami; J Gibson Lanier; Kenneth E Kokko; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Heterologous immunity provides a potent barrier to transplantation tolerance.
The Journal of clinical investigation 2003;111(12):1887-95.
2003: Ellen N Kersh; Susan M Kaech; Thandi M Onami; Miriana Moran; E John Wherry; M Carrie Miceli; Rafi Ahmed
TCR signal transduction in antigen-specific memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5455-63.
2003: Jason M Grayson; Nathan G Laniewski; J Gibson Lanier; Rafi Ahmed
Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4745-51.
2003: Joseph N Blattman; Jason M Grayson; E John Wherry; Susan M Kaech; Kendall A Smith; Rafi Ahmed
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo.
Nature medicine 2003;9(5):540-7.
2003: Rustom Antia; Carl T Bergstrom; Sergei S Pilyugin; Susan M Kaech; Rafi Ahmed
Models of CD8+ responses: 1. What is the antigen-independent proliferation program.
Journal of theoretical biology 2003;221(4):585-98.
2003: Susan M Kaech; Rafi Ahmed
Immunology. CD8 T cells remember with a little help.
Science (New York, N.Y.) 2003;300(5617):263-5.
2003: E John Wherry; Joseph N Blattman; Kaja Murali-Krishna; Robbert van der Most; Rafi Ahmed
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.
Journal of virology 2003;77(8):4911-27.
2003: Matthew A Williams; Andrew B Adams; Melody B Walsh; Nozomu Shirasugi; Thandi M Onami; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Primary and secondary immunocompetence in mixed allogeneic chimeras.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2382-9.
2003: E John Wherry; Volker Teichgräber; Todd C Becker; David Masopust; Susan M Kaech; Rustom Antia; Ulrich H von Andrian; Rafi Ahmed
Lineage relationship and protective immunity of memory CD8 T cell subsets.
Nature immunology 2003;4(3):225-34.
2003: Devon Shedlock; Jason K Whitmire; Joyce T Tan; Andrew S MacDonald; Rafi Ahmed; Hao Shen
Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2053-63.
2003: Hao Shen; Jason K Whitmire; Xin Fan; Devon Shedlock; Susan M Kaech; Rafi Ahmed
A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1443-51.
2003: Mark K Slifka; Joseph N Blattman; David J D Sourdive; Fei Liu; Donald L Huffman; Tom Wolfe; Anna Hughes; Michael B A Oldstone; Rafi Ahmed; Matthias G von Herrath
Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1231-9.
2003: Shane Crotty; Ellen N Kersh; Jennifer L Cannons; Pamela L Schwartzberg; Rafi Ahmed
SAP is required for generating long-term humoral immunity.
Nature 2003;421(6920):282-7.
2003: Robbert van der Most; Kaja Murali-Krishna; Rafi Ahmed
Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis.
International immunology 2003;15(1):119-25.
2003: Karen S Hathcock; Susan M Kaech; Rafi Ahmed; Richard J Hodes
Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):147-52.
2003: Francios VILLINGER; Ann Mayne; Pavel Bostik; Kazuyasu Mori; Peter E Jensen; Rafi Ahmed; Aftab A Ansari
Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques.
Journal of virology 2003;77(1):10-24.
2002: Susan M Kaech; Scott Hemby; Ellen N Kersh; Rafi Ahmed
Molecular and functional profiling of memory CD8 T cell differentiation.
Cell 2002;111(6):837-51.
2002: Matthew A Williams; Thandi M Onami; Andrew B Adams; Megan M Durham; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5387-91.
2002: Jason M Grayson; Laurie E Harrington; J Gibson Lanier; E John Wherry; Rafi Ahmed
Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3760-70.
2002: Christopher W McMahon; Allan J Zajac; Amanda M Jamieson; Laura Corral; Gianna Elena Hammer; Rafi Ahmed; David H Raulet
Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1444-52.
2002: Todd C Becker; E John Wherry; David Boone; Kaja Murali-Krishna; Rustom Antia; Averil Ma; Rafi Ahmed
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.
The Journal of experimental medicine 2002;195(12):1541-8.
2002: Thandi M Onami; Laurie E Harrington; Matthew A Williams; Marisa Galvan; Christian P Larsen; Thomas C Pearson; N Manjunath; Linda G Baum; Brad D Pearce; Rafi Ahmed
Dynamic regulation of T cell immunity by CD43.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6022-31.
2002: Zoher F Kapasi; Kaja Murali-Krishna; Michael L McRae; Rafi Ahmed
Defective generation but normal maintenance of memory T cells in old mice.
European journal of immunology 2002;32(6):1567-73.
2002: Robbert van der Most; Laurie E Harrington; Vicki Giuggio; Patryce L Mahar; Rafi Ahmed
Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in mice.
Virology 2002;296(1):117-24.
2002: Susan M Kaech; E John Wherry; Rafi Ahmed
Effector and memory T-cell differentiation: implications for vaccine development.
Nature reviews. Immunology 2002;2(4):251-62.
2002: M Suresh; Gibson Lanier; Mary Katherine Large; Jason K Whitmire; John D Altman; Nancy H Ruddle; Rafi Ahmed
Role of lymphotoxin alpha in T-cell responses during an acute viral infection.
Journal of virology 2002;76(8):3943-51.
2002: Laurie E Harrington; Robbert van der Most Rv; J Lindsay Whitton; Rafi Ahmed
Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope.
Journal of virology 2002;76(7):3329-37.
2002: Joseph N Blattman; Rustom Antia; David J D Sourdive; Xiaochi Wang; Susan M Kaech; Kaja Murali-Krishna; John D Altman; Rafi Ahmed
Estimating the precursor frequency of naive antigen-specific CD8 T cells.
The Journal of experimental medicine 2002;195(5):657-64.
2002: E John Wherry; Todd C Becker; David Boone; Murali-Krishna Kaja; Averil Ma; Rafi Ahmed
Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.
Advances in experimental medicine and biology 2002;512():165-75.
2001: M Suresh; Jason K Whitmire; Laurie E Harrington; Christian P Larsen; Thomas C Pearson; John D Altman; Rafi Ahmed
Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5565-73.
2001: Matthew A Williams; Joyce T Tan; Andrew B Adams; Megan M Durham; Nozomu Shirasugi; Jason K Whitmire; Laurie E Harrington; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4987-95.
2001: Rob J De Boer; M Oprea; Rustom Antia; Kaja Murali-Krishna; Rafi Ahmed; Alan S Perelson
Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus.
Journal of virology 2001;75(22):10663-9.
2001: Betty A Wu-Hsieh; Jason K Whitmire; R de Fries; Jr-Shiuan Lin; Mehrdad Matloubian; Rafi Ahmed
Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4566-73.
2001: Jason K Whitmire; Rafi Ahmed
The economy of T-cell memory: CD4+ recession in times of CD8+ stability?
Nature medicine 2001;7(8):892-3.
2001: Jason M Grayson; J Gibson Lanier; John D Altman; Rafi Ahmed
The role of p53 in regulating antiviral T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1333-7.
2001: John D Mountz; Gary Van Zant; Huang-Ge Zhang; William E Grizzle; Rafi Ahmed; Robert Williams; Hui-Chen Hsu
Genetic dissection of age-related changes of immune function in mice.
Scandinavian journal of immunology 2001;54(1-2):10-20.
2001: Michael J Czar; Ellen N Kersh; Lilia Mijares; G Lanier; J Lewis; G Yap; Amy Chen; Alan Sher; Colin S Duckett; Rafi Ahmed; Pamela L Schwartzberg
Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7449-54.
2001: Maryann T Puglielli; AJ Zajac; Robbert van der Most; John Dzuris; Alessandro Sette; John D Altman; Rafi Ahmed
In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb.
Journal of virology 2001;75(11):5099-107.
2001: M Gupta; S Mahanty; Rafi Ahmed; Pierre E Rollin
Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro.
Virology 2001;284(1):20-5.
2001: Susan M Kaech; Rafi Ahmed
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells.
Nature immunology 2001;2(5):415-22.
2001: Manisha Gupta; Siddhartha Mahanty; Mike Bray; Rafi Ahmed; Pierre E Rollin
Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication.
Journal of virology 2001;75(10):4649-54.
2001: C King; R Mueller Hoenger; M Malo Cleary; K Murali-Krishna; Rafi Ahmed; E King; Nora Sarvetnick
Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses.
Nature medicine 2001;7(2):206-14.
2001: Jason M Grayson; Kaja Murali-Krishna; John D Altman; Rafi Ahmed
Gene expression in antigen-specific CD8+ T cells during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):795-9.
2000: Joseph N Blattman; David J D Sourdive; Kaja Murali-Krishna; Rafi Ahmed; John D Altman
Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6081-90.
2000: Robbert van der Most; Kaja Murali-Krishna; Rafi Ahmed; James H Strauss
Chimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell response.
Journal of virology 2000;74(17):8094-101.
2000: Kaja Murali-Krishna; Rafi Ahmed
Cutting edge: naive T cells masquerading as memory cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1733-7.
2000: Jason K Whitmire; Rafi Ahmed
Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses.
Current opinion in immunology 2000;12(4):448-55.
2000: Jason M Grayson; AJ Zajac; John D Altman; Rafi Ahmed
Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):3950-4.
2000: Laurie E Harrington; Marisa Galvan; Linda G Baum; John D Altman; Rafi Ahmed
Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans.
The Journal of experimental medicine 2000;191(7):1241-6.
2000: Jason K Whitmire; Kaja Murali-Krishna; John D Altman; Rafi Ahmed
Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1395):373-9.
2000: Joyce T Tan; Jason K Whitmire; Kaja Murali-Krishna; Rafi Ahmed; John D Altman; Robert S Mittler; Alessandro Sette; Thomas C Pearson; Christian P Larsen
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2320-5.
1999: Maryann T Puglielli; J L Browning; A W Brewer; R D Schreiber; W J Shieh; John D Altman; Michael B A Oldstone; S R Zaki; Rafi Ahmed
Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.
Nature medicine 1999;5(12):1370-4.
1999: AJ Zajac; Russell E Vance; W Held; David J D Sourdive; John D Altman; David H Raulet; Rafi Ahmed
Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5526-34.
1999: Kaja Murali-Krishna; L L Lau; S Sambhara; F Lemonnier; John D Altman; Rafi Ahmed
Persistence of memory CD8 T cells in MHC class I-deficient mice.
Science (New York, N.Y.) 1999;286(5443):1377-81.
1999: Joyce T Tan; Jason K Whitmire; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4859-68.
1999: J Gibson Lanier; MJ Newman; E M Lee; Alessandro Sette; Rafi Ahmed
Peptide vaccination using nonionic block copolymers induces protective anti-viral CTL responses.
Vaccine 1999;18(5-6):549-57.
1999: Jason K Whitmire; Richard A Flavell; Iqbal Grewal; Christian P Larsen; Thomas C Pearson; Rafi Ahmed
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3194-201.
1999: A M Doling; Jimmy D Ballard; H Shen; K M Krishna; Rafi Ahmed; R. John Collier; Michael N Starnbach
Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity.
Infection and immunity 1999;67(7):3290-6.
1999: LP Cousens; R Peterson; S Hsu; A Dorner; John D Altman; Rafi Ahmed; Christine A Biron
Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection.
The Journal of experimental medicine 1999;189(8):1315-28.
1999: Michael G McHeyzer-Williams; Rafi Ahmed
B cell memory and the long-lived plasma cell.
Current opinion in immunology 1999;11(2):172-9.
1999: Mehrdad Matloubian; M Suresh; A Glass; Marisa Galvan; Kira Chow; Jason K Whitmire; C M Walsh; W R Clark; Rafi Ahmed
A role for perforin in downregulating T-cell responses during chronic viral infection.
Journal of virology 1999;73(3):2527-36.
1998: AJ Zajac; Joseph N Blattman; Kaja Murali-Krishna; David J D Sourdive; M Suresh; John D Altman; Rafi Ahmed
Viral immune evasion due to persistence of activated T cells without effector function.
The Journal of experimental medicine 1998;188(12):2205-13.
1998: Rustom Antia; Sergei S Pilyugin; Rafi Ahmed
Models of immune memory: on the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14926-31.
1998: Jason K Whitmire; M S Asano; Kaja Murali-Krishna; M Suresh; Rafi Ahmed
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection.
Journal of virology 1998;72(10):8281-8.
1998: AJ Zajac; Kaja Murali-Krishna; Joseph N Blattman; Rafi Ahmed
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.
Current opinion in immunology 1998;10(4):444-9.
1998: Marisa Galvan; Kaja Murali-Krishna; L L Ming; L Baum; Rafi Ahmed
Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector/memory CD8+ T cells from naive cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):641-8.
1998: David J D Sourdive; Kaja Murali-Krishna; John D Altman; AJ Zajac; Jason K Whitmire; Christophe Pannetier; Philippe Kourilsky; Brian D Evavold; Alessandro Sette; Rafi Ahmed
Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection.
The Journal of experimental medicine 1998;188(1):71-82.
1998: KJ Flynn; Gabrielle Belz; John D Altman; Rafi Ahmed; David L Woodland; Peter C Doherty
Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.
Immunity 1998;8(6):683-91.
1998: Mark K Slifka; Rafi Ahmed
Long-lived plasma cells: a mechanism for maintaining persistent antibody production.
Current opinion in immunology 1998;10(3):252-8.
1998: HC Su; LP Cousens; Loren D Fast; Mark K Slifka; RD Bungiro; Rafi Ahmed; Christine A Biron
CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):5007-17.
1998: Mark K Slifka; Rustom Antia; Jason K Whitmire; Rafi Ahmed
Humoral immunity due to long-lived plasma cells.
Immunity 1998;8(3):363-72.
1998: H Shen; J F Miller; X Fan; D Kolwyck; Rafi Ahmed; J T Harty
Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.
Cell 1998;92(4):535-45.
1998: Kaja Murali-Krishna; John D Altman; M Suresh; David J D Sourdive; AJ Zajac; Joseph D Miller; Jill E Slansky; Rafi Ahmed
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.
Immunity 1998;8(2):177-87.
1998: Robbert van der Most; Kaja Murali-Krishna; J L Whitton; Carla Oseroff; J Alexander; Scott Southwood; John Sidney; Robert W Chesnut; Alessandro Sette; Rafi Ahmed
Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice.
Virology 1998;240(1):158-67.
1998: Kaja Murali-Krishna; John D Altman; M Suresh; David J D Sourdive; AJ Zajac; Rafi Ahmed
In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection.
Advances in experimental medicine and biology 1998;452():123-42.
1998: Mark K Slifka; Rafi Ahmed
B cell responses and immune memory.
Developments in biological standardization 1998;95():105-15.
1997: ER Jensen; R Selvakumar; Hao Shen; Rafi Ahmed; FO Wettstein; JF Miller
Recombinant Listeria monocytogenes vaccination eliminates papillomavirus-induced tumors and prevents papilloma formation from viral DNA.
Journal of virology 1997;71(11):8467-74.
1997: Mark K Slifka; Jason K Whitmire; Rafi Ahmed
Bone marrow contains virus-specific cytotoxic T lymphocytes.
Blood 1997;90(5):2103-8.
1997: ER Jensen; Hao Shen; FO Wettstein; Rafi Ahmed; JF Miller
Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell-mediated immunity.
Immunological reviews 1997;158():147-57.
1997: R Selvakumar; A Schmitt; T Iftner; Rafi Ahmed; FO Wettstein
Regression of papillomas induced by cottontail rabbit papillomavirus is associated with infiltration of CD8+ cells and persistence of viral DNA after regression.
Journal of virology 1997;71(7):5540-8.
1997: Robbert van der Most; R J Concepcion; Carla Oseroff; J Alexander; Scott Southwood; John Sidney; Robert W Chesnut; Rafi Ahmed; Alessandro Sette
Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice.
Journal of virology 1997;71(7):5110-4.
1997: Michael B McChesney; Christopher J Miller; Paul A Rota; YD Zhu; L Antipa; Nicholas W Lerche; Rafi Ahmed; William Joseph Bellini
Experimental measles. I. Pathogenesis in the normal and the immunized host.
Virology 1997;233(1):74-84.
1996: Robbert van der Most; Alessandro Sette; Carla Oseroff; J Alexander; Kaja Murali-Krishna; L L Lau; Scott Southwood; John Sidney; Robert W Chesnut; M Matloubian; Rafi Ahmed
Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5543-54.
1996: Jason K Whitmire; Mark K Slifka; Iqbal Grewal; R A Flavell; Rafi Ahmed
CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection.
Journal of virology 1996;70(12):8375-81.
1996: Mark K Slifka; Rafi Ahmed
Limiting dilution analysis of virus-specific memory B cells by an ELISPOT assay.
Journal of immunological methods 1996;199(1):37-46.
1996: Mark K Slifka; Rafi Ahmed
Long-term antibody production is sustained by antibody-secreting cells in the bone marrow following acute viral infection.
Annals of the New York Academy of Sciences 1996;797():166-76.
1996: Mark K Slifka; Rafi Ahmed
Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity.
Trends in microbiology 1996;4(10):394-400.
1996: Rafi Ahmed
Tickling memory T cells.
Science (New York, N.Y.) 1996;272(5270):1904.
1996: M S Asano; Rafi Ahmed
CD8 T cell memory in B cell-deficient mice.
The Journal of experimental medicine 1996;183(5):2165-74.
1996: Mark K Slifka; Hao Shen; M Matloubian; ER Jensen; Jeff F Miller; Rafi Ahmed
Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
Journal of virology 1996;70(5):2902-10.
1996: Rafi Ahmed; D Gray
Immunological memory and protective immunity: understanding their relation.
Science (New York, N.Y.) 1996;272(5258):54-60.
1996: Beate C Sydora; Beth D Jamieson; Rafi Ahmed; Mitchell Kronenberg
Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection.
Cellular immunology 1996;167(2):161-9.
1995: K E Wright; Rafi Ahmed; Michael J Buchmeier
Persistent infection of mice with Pichinde virus associated with failure to thrive.
Microbial pathogenesis 1995;19(2):73-82.
1995: W R Clark; C M Walsh; A A Glass; F Hayashi; M Matloubian; Rafi Ahmed
Molecular pathways of CTL-mediated cytotoxicity.
Immunological reviews 1995;146():33-44.
1995: Hao Shen; Mark K Slifka; M Matloubian; ER Jensen; Rafi Ahmed; Jeff F Miller
Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3987-91.
1995: R Selvakumar; Rafi Ahmed; F O Wettstein
Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus.
Virology 1995;208(1):298-302.
1995: L Villarete; R de Fries; S Kolhekar; D Howard; Rafi Ahmed; B Wu-Hsieh
Impaired responsiveness to gamma interferon of macrophages infected with lymphocytic choriomeningitis virus clone 13: susceptibility to histoplasmosis.
Infection and immunity 1995;63(4):1468-72.
1995: L P Martins; L L Lau; M S Asano; Rafi Ahmed
DNA vaccination against persistent viral infection.
Journal of virology 1995;69(4):2574-82.
1995: Mark K Slifka; M Matloubian; Rafi Ahmed
Bone marrow is a major site of long-term antibody production after acute viral infection.
Journal of virology 1995;69(3):1895-902.
1995: M S Asano; Rafi Ahmed
Immune conflicts in lymphocytic choriomeningitis virus.
Springer seminars in immunopathology 1995;17(2-3):247-59.
1995: R Selvakumar; L A Borenstein; Y L Lin; Rafi Ahmed; F O Wettstein
Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.
Journal of virology 1995;69(1):602-5.
1995: W R Clark; C M Walsh; A A Glass; M T Huang; Rafi Ahmed; M Matloubian
Cell-mediated cytotoxicity in perforin-less mice.
International reviews of immunology 1995;13(1):1-14.
1994: M Matloubian; R J Concepcion; Rafi Ahmed
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
Journal of virology 1994;68(12):8056-63.
1994: C M Walsh; M Matloubian; C C Liu; R Ueda; C G Kurahara; J L Christensen; M T Huang; J D Young; Rafi Ahmed; W R Clark
Immune function in mice lacking the perforin gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10854-8.
1994: L Villarete; T Somasundaram; Rafi Ahmed
Tissue-mediated selection of viral variants: correlation between glycoprotein mutation and growth in neuronal cells.
Journal of virology 1994;68(11):7490-6.
1994: L L Lau; Beth D Jamieson; T Somasundaram; Rafi Ahmed
Cytotoxic T-cell memory without antigen.
Nature 1994;369(6482):648-52.
1994: R Selvakumar; L A Borenstein; Y L Lin; Rafi Ahmed; F O Wettstein
T-cell response to cottontail rabbit papillomavirus structural proteins in infected rabbits.
Journal of virology 1994;68(6):4043-8.
1993: M Matloubian; S R Kolhekar; T Somasundaram; Rafi Ahmed
Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
Journal of virology 1993;67(12):7340-9.
1993: Y L Lin; L A Borenstein; Rafi Ahmed; F O Wettstein
Cottontail rabbit papillomavirus L1 protein-based vaccines: protection is achieved only with a full-length, nondenatured product.
Journal of virology 1993;67(7):4154-62.
1993: Y L Lin; L A Borenstein; R Selvakumar; Rafi Ahmed; F O Wettstein
Progression from papilloma to carcinoma is accompanied by changes in antibody response to papillomavirus proteins.
Journal of virology 1993;67(1):382-9.
1992: C C King; Beth D Jamieson; K Reddy; N Bali; R J Concepcion; Rafi Ahmed
Viral infection of the thymus.
Journal of virology 1992;66(5):3155-60.
1992: Rafi Ahmed
Immunological memory against viruses.
Seminars in immunology 1992;4(2):105-9.
1992: Y L Lin; L A Borenstein; R Selvakumar; Rafi Ahmed; F O Wettstein
Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus.
Virology 1992;187(2):612-9.
1991: Antoinette Tishon; A Salmi; Rafi Ahmed; Michael B A Oldstone
Role of viral strains and host genes in determining levels of immune complexes in a model system: implications for HIV infection.
AIDS research and human retroviruses 1991;7(12):963-9.
1991: Beth D Jamieson; T Somasundaram; Rafi Ahmed
Abrogation of tolerance to a chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3521-9.
1991: Rafi Ahmed; C S Hahn; T Somasundaram; L Villarete; M Matloubian; J H Strauss
Molecular basis of organ-specific selection of viral variants during chronic infection.
Journal of virology 1991;65(8):4242-7.
1991: Rafi Ahmed
T-cell tolerance to viruses.
Current opinion in immunology 1991;3(4):476-9.
1990: C C King; R de Fries; S R Kolhekar; Rafi Ahmed
In vivo selection of lymphocyte-tropic and macrophage-tropic variants of lymphocytic choriomeningitis virus during persistent infection.
Journal of virology 1990;64(11):5611-6.
1990: M Matloubian; T Somasundaram; S R Kolhekar; R Selvakumar; Rafi Ahmed
Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.
The Journal of experimental medicine 1990;172(4):1043-8.
1990: M B Oldstone; Rafi Ahmed; Maria Salvato
Viruses as therapeutic agents. II. Viral reassortants map prevention of insulin-dependent diabetes mellitus to the small RNA of lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1990;171(6):2091-100.
1989: Beth D Jamieson; Rafi Ahmed
T cell memory. Long-term persistence of virus-specific cytotoxic T cells.
The Journal of experimental medicine 1989;169(6):1993-2005.
1988: Rafi Ahmed; R S Simon; M Matloubian; S R Kolhekar; P J Southern; D M Freedman
Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus.
Journal of virology 1988;62(9):3301-8.
1988: B Wu-Hsieh; D H Howard; Rafi Ahmed
Virus-induced immunosuppression: a murine model of susceptibility to opportunistic infection.
The Journal of infectious diseases 1988;158(1):232-5.
1988: Rafi Ahmed; L D Butler; L Bhatti
T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses.
Journal of virology 1988;62(6):2102-6.
1988: Rafi Ahmed; M B Oldstone
Organ-specific selection of viral variants during chronic infection.
The Journal of experimental medicine 1988;167(5):1719-24.
1988: Beth D Jamieson; Rafi Ahmed
T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2265-8.
1987: Rafi Ahmed; Beth D Jamieson; David D Porter
Immune therapy of a persistent and disseminated viral infection.
Journal of virology 1987;61(12):3920-9.
1987: Beth D Jamieson; L D Butler; Rafi Ahmed
Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells.
Journal of virology 1987;61(12):3930-7.
1987: Rafi Ahmed; C C King; M B Oldstone
Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo.
Journal of virology 1987;61(5):1571-6.
1986: V Valsamakis; P Southern; Paul Blount; Rafi Ahmed; M J Buchmeier; M B Oldstone
Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus.
Medical microbiology and immunology 1986;175(2-3):97-9.
1986: Y Riviere; Rafi Ahmed; M B Oldstone
The use of lymphocytic choriomeningitis virus reassortants to map viral genes causing virulence.
Medical microbiology and immunology 1986;175(2-3):191-2.
1986: Y Riviere; P J Southern; Rafi Ahmed; M B Oldstone
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(1):304-7.
1985: Y Riviere; Rafi Ahmed; P J Southern; Michael J Buchmeier; M B Oldstone
Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment.
Journal of virology 1985;55(3):704-9.
1985: Y Riviere; Rafi Ahmed; P Southern; M B Oldstone
Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome.
Virology 1985;142(1):175-82.
1985: M B Oldstone; Rafi Ahmed; M J Buchmeier; Paul Blount; A Tishon
Perturbation of differentiated functions during viral infection in vivo. I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency.
Virology 1985;142(1):158-74.
1985: Y Riviere; Rafi Ahmed; P J Southern; Michael J Buchmeier; F J Dutko; M B Oldstone
The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2.
Journal of virology 1985;53(3):966-8.
1985: M B Oldstone; Rafi Ahmed; J Byrne; Michael J Buchmeier; Y Riviere; P Southern
Virus and immune responses: lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis.
British medical bulletin 1985;41(1):70-4.
1984: Rafi Ahmed; A Salmi; L D Butler; J M Chiller; M B Oldstone
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
The Journal of experimental medicine 1984;160(2):521-40.
1984: Rafi Ahmed; J A Byrne; M B Oldstone
Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains.
Journal of virology 1984;51(1):34-41.
1984: J A Byrne; Rafi Ahmed; M B Oldstone
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(1):433-9.
1983: R S Kauffman; Rafi Ahmed; B N Fields
Selection of a mutant S1 gene during reovirus persistent infection of L cells: role in maintenance of the persistent state.
Virology 1983;131(1):79-87.
1983: Rafi Ahmed; R S Kauffman; B N Fields
Genetic variation during persistent reovirus infection: isolation of cold-sensitive and temperature-sensitive mutants from persistently infected L cells.
Virology 1983;131(1):71-8.
1983: R F Ramig; Rafi Ahmed; B N Fields
A genetic map of reovirus: assignment of the newly defined mutant groups H, I, and J to genome segments.
Virology 1983;125(2):299-313.
1982: Rafi Ahmed; B N Fields
Role of the S4 gene in the establishment of persistent reovirus infection in L cells.
Cell 1982;28(3):605-12.
1981: Rafi Ahmed; W M Canning; R S Kauffman; A H Sharpe; J V Hallum; B N Fields
Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection.
Cell 1981;25(2):325-32.
1981: Rafi Ahmed; B N Fields
Reassortment of genome segments between reovirus defective interfering particles and infectious virus: construction of temperature-sensitive and attenuated viruses by rescue of mutations from DI particles.
Virology 1981;111(2):351-63.
1980: Rafi Ahmed; P R Chakraborty; A F Graham; R F Ramig; B N Fields
Genetic variation during persistent reovirus infection: presence of extragenically suppressed temperature-sensitive lesions in wild-type virus isolated from persistently infected L cells.
Journal of virology 1980;34(2):383-9.
1980: Rafi Ahmed; P R Chakraborty; B N Fields
Genetic variation during lytic reovirus infection: high-passage stocks of wild-type reovirus contain temperature-sensitive mutants.
Journal of virology 1980;34(1):285-7.
1979: P R Chakraborty; Rafi Ahmed; B N Fields
Genetics of reovirus: the relationship of interference to complementation and reassortment of temperature-sensitive mutants at nonpermissive temperature.
Virology 1979;94(1):119-27.
1977: Rafi Ahmed; A F Graham
Persistent infections in L cells with temperature-sensitive mutants of reovirus.
Journal of virology 1977;23(2):250-62.