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Eric Simanek

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Chemicals & Drugs

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Publications

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Jongdoo Lim; Jan Maly; Giovanni M Pavan; Onofrio Annunziata; Viviana C P da Costa; Mauri Kostiainen; Eric E Simanek
Synthesis of large dendrimers with the dimensions of small viruses.
Jongdoo Lim; Nakajima Takahitio; Giovanni M Pavan; Eric E Simanek; Baris Turkbey; Marcelino Bernardo; L Henry Bryant; Peter L Choyke; Matteo Garzoni; Hisataka Kobayashi
Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics.
Nandhini Muthukrishnan; Gregory A Johnson; Jongdoo Lim; Eric E Simanek; Jean-Philippe Pellois
TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells.

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All Publications

2013: Jongdoo Lim; Jan Maly; Giovanni M Pavan; Onofrio Annunziata; Viviana C P da Costa; Mauri Kostiainen; Eric E Simanek
Synthesis of large dendrimers with the dimensions of small viruses.
Journal of the American Chemical Society 2013;135(12):4660-3.
2012: Jongdoo Lim; Nakajima Takahitio; Giovanni M Pavan; Eric E Simanek; Baris Turkbey; Marcelino Bernardo; L Henry Bryant; Peter L Choyke; Matteo Garzoni; Hisataka Kobayashi
Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics.
Bioconjugate chemistry 2012;23(11):2291-9.
2012: Nandhini Muthukrishnan; Gregory A Johnson; Jongdoo Lim; Eric E Simanek; Jean-Philippe Pellois
TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells.
Biochimica et biophysica acta 2012;1820(11):1734-43.
2012: Jongdoo Lim; Su-Tang Lo; Giovanni M Pavan; Sonia Hill; Xiankai Sun; Eric E Simanek
Antitumor activity and molecular dynamics simulations of paclitaxel-laden triazine dendrimers.
Molecular pharmaceutics 2012;9(3):404-12.
2012: Jongdoo Lim; Giovanni M Pavan; Onofrio Annunziata; Eric E Simanek
Experimental and computational evidence for an inversion in guest capacity in high-generation triazine dendrimer hosts.
Journal of the American Chemical Society 2012;134(4):1942-5.
2011: Olivia Merkel; Meredith A Mintzer; Giovanni M Pavan; Eric E Simanek; Mengyao Zheng; Andrea Danani; Helmut Höffken; Damiano Librizzi; Marek Maly; Thomas Kissel
Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2011;153(1):23-33.
2011: Divyamani Srinivasan; Nandhini Muthukrishnan; Gregory A Johnson; Alfredo Erazo-Oliveras; Jongdoo Lim; Eric E Simanek; Jean-Philippe Pellois
Conjugation to the cell-penetrating peptide TAT potentiates the photodynamic effect of carboxytetramethylrhodamine.
PloS one 2011;6(3):e17732.
2010: Olivia Merkel; Meredith A Mintzer; Eric E Simanek; Thomas Kissel
Perfectly shaped siRNA delivery.
Therapeutic delivery 2010;1(6):737-42.
2010: Jongdoo Lim; Jean-Philippe Pellois; Eric E Simanek
A retro-inverso TAT-like peptide designed to deliver cysteamine to cells.
Bioorganic & medicinal chemistry letters 2010;20(21):6321-3.
2010: Olivia Merkel; Meredith A Mintzer; Damiano Librizzi; Olga Samsonova; Tanja Dicke; Brian Sproat; Holger Garn; Peter J Barth; Eric E Simanek; Thomas Kissel
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity.
Molecular pharmaceutics 2010;7(4):969-83.
2010: Jongdoo Lim; Vincent J Venditto; Eric E Simanek
Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups.
Bioorganic & medicinal chemistry 2010;18(15):5749-53.
2010: Vincent J Venditto; Eric E Simanek
Cancer therapies utilizing the camptothecins: a review of the in vivo literature.
Molecular pharmaceutics 2010;7(2):307-49.
2010: Jongdoo Lim; Meredith A Mintzer; Lisa M Perez; Eric E Simanek
Synthesis of odd generation triazine dendrimers using a divergent, macromonomer approach.
Organic letters 2010;12(6):1148-51.
2010: Giovanni M Pavan; Meredith A Mintzer; Eric E Simanek; Olivia Merkel; Thomas Kissel; Andrea Danani
Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers.
Biomacromolecules 2010;11(3):721-30.
2009: Jongdoo Lim; Abdellatif Chouai; Su-Tang Lo; Wei Liu; Xiankai Sun; Eric E Simanek
Design, synthesis, characterization, and biological evaluation of triazine dendrimers bearing paclitaxel using ester and ester/disulfide linkages.
Bioconjugate chemistry 2009;20(11):2154-61.
2009: Vincent J Venditto; Kimberly Allred; Clinton D Allred; Eric E Simanek
Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles.
Chemical communications (Cambridge, England) 2009;(37):5541-2.
2009: Olivia Merkel; Meredith A Mintzer; Johannes Sitterberg; Udo Bakowsky; Eric E Simanek; Thomas Kissel
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Bioconjugate chemistry 2009;20(9):1799-806.
2009: Meredith A Mintzer; Eric E Simanek
Nonviral vectors for gene delivery.
Chemical reviews 2009;109(2):259-302.
2008: Jongdoo Lim; Yi Guo; Cynthia L Rostollan; Jennifer Stanfield; Jer-Tsong Hsieh; Xiankai Sun; Eric E Simanek
The role of the size and number of polyethylene glycol chains in the biodistribution and tumor localization of triazine dendrimers.
Molecular pharmaceutics 2008;5(4):540-7.
2008: Abdellatif Chouai; Eric E Simanek
Kilogram-scale synthesis of a second-generation dendrimer based on 1,3,5-triazine using green and industrially compatible methods with a single chromatographic step.
The Journal of organic chemistry 2008;73(6):2357-66.
2008: Jongdoo Lim; Eric E Simanek
Synthesis of water-soluble dendrimers based on melamine bearing 16 paclitaxel groups.
Organic letters 2008;10(2):201-4.
2007: Alona P Umali; Hannah L Crampton; Eric E Simanek
Triazine dendrimers with orthogonally protected amines on the periphery. Masking amines with Dde and BOC groups provides an alternative to carrying protected alcohols and disulfides through an iterative synthesis.
The Journal of organic chemistry 2007;72(26):9866-74.
2006: Susan L Neitsch; Kevin Joseph McInnes; Scott A Senseman; G Norman White; Eric E Simanek
Melamine-based organoclay to sequester atrazine.
Chemosphere 2006;64(5):704-10.
2006: Emily Hollink; Eric E Simanek
A divergent route to diversity in macromolecules.
Organic letters 2006;8(11):2293-5.
2005: David M Ford; Eric E Simanek; Daniel F Shantz
Engineering nanospaces: ordered mesoporous silicas as model substrates for building complex hybrid materials.
Nanotechnology 2005;16(7):S458-75.
2005: Jongdoo Lim; Eric E Simanek
Toward the next-generation drug delivery vehicle: synthesis of a dendrimer with four orthogonally reactive groups.
Molecular pharmaceutics 2005;2(4):273-7.
2005: Eric E Simanek
"Magic" may grow on trees...
Molecular pharmaceutics 2005;2(4):251-2.
2004: Mackay B Steffensen; Eric E Simanek
Synthesis and manipulation of orthogonally protected dendrimers: building blocks for library synthesis.
Angewandte Chemie (International ed. in English) 2004;43(39):5178-80.
2004: Michael F Neerman; Hui-Ting Chen; Alan R Parrish; Eric E Simanek
Reduction of drug toxicity using dendrimers based on melamine.
Molecular pharmaceutics 2004;1(5):390-3.
2004: Michael F Neerman; Wen Zhang; Alan R Parrish; Eric E Simanek
In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery.
International journal of pharmaceutics 2004;281(1-2):129-32.
2004: Hui-Ting Chen; Michael F Neerman; Alan R Parrish; Eric E Simanek
Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery.
Journal of the American Chemical Society 2004;126(32):10044-8.
2004: Erick J Acosta; Mackay B Steffensen; Shane E Tichy; Eric E Simanek
Removal of atrazine from water using covalent sequestration.
Journal of agricultural and food chemistry 2004;52(3):545-9.
2003: Mackay B Steffensen; Eric E Simanek
Chemoselective building blocks for dendrimers from relative reactivity data.
Organic letters 2003;5(13):2359-61.
2003: Wen Zhang; Shane E Tichy; Lisa M Pérez; Gheorghe C Maria; Paul A Lindahl; Eric E Simanek
Evaluation of multivalent dendrimers based on melamine: kinetics of thiol-disulfide exchange depends on the structure of the dendrimer.
Journal of the American Chemical Society 2003;125(17):5086-94.
2003: Alona P Umali; Eric E Simanek
Thiol-disulfide exchange yields multivalent dendrimers of melamine.
Organic letters 2003;5(8):1245-7.
2003: Stephen A Bell; Megan E McLean; Sang-Keun Oh; Shane E Tichy; Wen Zhang; Robert M Corn; Richard M Crooks; Eric E Simanek
Synthesis and characterization of covalently linked single-stranded DNA oligonucleotide-dendron conjugates.
Bioconjugate chemistry 2003;14(2):488-93.
2001: Wen Zhang; Daniel T Nowlan; Lisa M Thomson; William M Lackowski; Eric E Simanek
Orthogonal, convergent syntheses of dendrimers based on melamine with one or two unique surface sites for manipulation.
Journal of the American Chemical Society 2001;123(37):8914-22.

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