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Patricia Sime

Research Profile

Anatomy

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Hsi-Min Hsiao; Elizabeth P Levy; Keith C Olsen; Richard P Phipps; Stephen J Pollock; Ramil E Sapinoro; Charles N Serhan; Amanda Croasdell; Robert A Fulton; Thomas H Thatcher; Patricia J Sime
A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.
Sesquile Ramon; Julie M Sahler; Patricia J Sime; Thomas H Thatcher; Simona Bancos; Andrea Bottaro; Safiehkhatoon Moshkani; Thomas I Murant; Richard P Phipps
Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response.
Elizabeth R Davies; Arasu Ganesan; Hans Michael Haitchi; R Matthew Kottmann; Katherine M A O'Reilly; Graham Packham; Patricia J Sime; Thomas H Thatcher; Donna E Davies
Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

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All Publications

2013: Hsi-Min Hsiao; Elizabeth P Levy; Keith C Olsen; Richard P Phipps; Stephen J Pollock; Ramil E Sapinoro; Charles N Serhan; Amanda Croasdell; Robert A Fulton; Thomas H Thatcher; Patricia J Sime
A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.
PloS one 2013;8(3):e58258.
2012: Sesquile Ramon; Julie M Sahler; Patricia J Sime; Thomas H Thatcher; Simona Bancos; Andrea Bottaro; Safiehkhatoon Moshkani; Thomas I Murant; Richard P Phipps
Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4740-7.
2012: Elizabeth R Davies; Arasu Ganesan; Hans Michael Haitchi; R Matthew Kottmann; Katherine M A O'Reilly; Graham Packham; Patricia J Sime; Thomas H Thatcher; Donna E Davies
Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2012;46(5):687-94.
2012: Raju C Reddy; Virender K Rehan; Jesse Roman; Patricia J Sime
PPARs: Regulators and Translational Targets in the Lung.
PPAR research 2012;2012():342924.
2012: Ajit A Kulkarni; Richard P Phipps; Sesquile Ramon; Thomas H Thatcher; Collynn F Woeller; Patricia J Sime
Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases.
PPAR research 2012;2012():705352.
2012: A E Kuriyan; G M Lehmann; Patricia J Sime; Collynn F Woeller; Steven E Feldon; H B Hindman; Krystel R Huxlin; A A Kulkarni; Richard P Phipps
Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.
Experimental eye research 2012;94(1):136-45.
2011: Neil Blumberg; Patricia J Sime; Richard P Phipps
The mystery of transfusion-related acute lung injury.
Transfusion 2011;51(10):2054-7.
2011: Robert Matthew Kottmann; Elizabeth Lyda; Karoline Moon; Wayne Ormsby; Michael Gurell; Jennifer Kelly; Jennifer Stalica; David R Trawick; Patricia J Sime
Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients.
Thorax 2011;66(9):823.
2011: David H McMillan; Carolyn J Baglole; Sanjay B Maggirwar; Patricia J Sime; Thomas H Thatcher; Richard P Phipps
Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation.
The American journal of pathology 2011;179(1):125-33.
2011: Xin Lin; Patricia J Sime; Marc A Williams; Haodong Xu; Steve N Georas; Larry LaRussa; Jia Guo
Yin yang 1 is a novel regulator of pulmonary fibrosis.
American journal of respiratory and critical care medicine 2011;183(12):1689-97.
2011: Xia Xi; Patricia J Sime; Steven E Feldon; Krystel R Huxlin; Geniece M Lehmann; Richard T Libby; David H McMillan; Richard P Phipps
Ocular fibroblast diversity: implications for inflammation and ocular wound healing.
Investigative ophthalmology & visual science 2011;52(7):4859-65.
2011: Geniece M Lehmann; Xia Xi; Ajit A Kulkarni; Keith C Olsen; Stephen J Pollock; Carolyn J Baglole; Shikha Gupta; Ann E Casey; Krystel R Huxlin; Patricia J Sime; Steven E Feldon; Richard P Phipps
The aryl hydrocarbon receptor ligand ITE inhibits TGFβ1-induced human myofibroblast differentiation.
The American journal of pathology 2011;178(4):1556-67.
2011: Christopher M Hogan; Carolyn Jones; Richard P Phipps; Stephen J Pollock; Ramil E Sapinoro; Heather E Ferguson; Michael N Gurell; Thomas H Thatcher; Patricia J Sime
Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism.
PPAR research 2011;2011():318134.
2011: Ajit A Kulkarni; Thomas H Thatcher; Keith C Olsen; Sanjay B Maggirwar; Richard P Phipps; Patricia J Sime
PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.
PloS one 2011;6(1):e15909.
2010: Patricia J Simpson-Haidaris; Kathryn Seweryniak; Sherry L Spinelli; Tatiana M Garcia-Bates; Thomas I Murant; Stephen J Pollock; Patricia J Sime; Richard P Phipps
A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis.
Journal of biotechnology 2010;150(3):417-27.
2010: Christopher Manganaris; Steven Wittlin; Haodong Xu; Michael Gurell; Patricia J Sime; Robert Matthew Kottmann
Metastatic papillary thyroid carcinoma and severe airflow obstruction.
Chest 2010;138(3):738-42.
2010: Emily A Desmet; Joseph A Hollenbaugh; Patricia J Sime; Terry W Wright; David J Topham; Andrea J Sant; Toru Takimoto; Stephen Dewhurst; Sanjay B Maggirwar
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.
Virology 2010;400(2):224-32.
2009: Heather E Ferguson; Ajit Kulkarni; Geniece M Lehmann; Tatiana M Garcia-Bates; Thomas H Thatcher; Krystel R Huxlin; Richard P Phipps; Patricia J Sime
Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.
American journal of respiratory cell and molecular biology 2009;41(6):722-30.
2009: Heather E Ferguson; Thomas H Thatcher; Keith C Olsen; Tatiana M Garcia-Bates; Carolyn J Baglole; R M Kottmann; Emily R Strong; Richard P Phipps; Patricia J Sime
Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L912-9.
2009: Robert Matthew Kottmann; Christopher M Hogan; Richard P Phipps; Patricia J Sime
Determinants of initiation and progression of idiopathic pulmonary fibrosis.
Respirology (Carlton, Vic.) 2009;14(7):917-33.
2009: Se-Ran Yang; Hongwei Yao; Saravanan Rajendrasozhan; Sangwoon Chung; Indika Edirisinghe; Samantha Valvo; George Fromm; Michael J McCabe; Patricia J Sime; Richard P Phipps; Jian-Dong Li; Michael Bulger; Irfan Rahman
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.
American journal of respiratory cell and molecular biology 2009;40(2):147-58.
2008: Carolyn J Baglole; Sanjay B Maggirwar; Thomas A Gasiewicz; Thomas H Thatcher; Richard P Phipps; Patricia J Sime
The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.
The Journal of biological chemistry 2008;283(43):28944-57.
2008: Carolyn J Baglole; Patricia J Sime; Richard P Phipps
Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione.
American journal of physiology. Lung cellular and molecular physiology 2008;295(4):L624-36.
2008: Michael N Gurell; R Matthew Kottmann; Haodong Xu; Patricia J Sime
Exogenous lipoid pneumonia: an unexpected complication of substance abuse.
Annals of internal medicine 2008;149(5):364-5.
2008: Thomas H Thatcher; Randi P Benson; Richard P Phipps; Patricia J Sime
High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function.
American journal of physiology. Lung cellular and molecular physiology 2008;295(3):L412-21.
2008: Patricia J Sime
The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2008;56(2):534-8.
2008: C Michael Hart; Jesse Roman; Raju C Reddy; Patricia J Sime
PPARgamma: a novel molecular target in lung disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2008;56(2):515-7.
2008: Tatiana M Garcia-Bates; Geniece M Lehmann; Patricia J Simpson-Haidaris; Steven H Bernstein; Patricia J Sime; Richard P Phipps
Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.
PPAR research 2008;2008():834612.
2007: Jack Gauldie; Philippe Bonniaud; Patricia J Sime; Kjetil Ask; Martin Kolb
TGF-beta, Smad3 and the process of progressive fibrosis.
Biochemical Society transactions 2007;35(Pt 4):661-4.
2007: Katherine M A O'Reilly; Anne Marie Mclaughlin; William S Beckett; Patricia J Sime
Asbestos-related lung disease.
American family physician 2007;75(5):683-8.
2007: Thomas H Thatcher; Sanjay B Maggirwar; Carolyn J Baglole; Heather F Lakatos; Thomas A Gasiewicz; Richard P Phipps; Patricia J Sime
Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.
The American journal of pathology 2007;170(3):855-64.
2007: Heather F Lakatos; Thomas H Thatcher; R Matthew Kottmann; Tatiana M Garcia; Richard P Phipps; Patricia J Sime
The Role of PPARs in Lung Fibrosis.
PPAR research 2007;2007():71323.
2006: A P Shah; H Xu; Patricia J Sime; David R Trawick
Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome.
The European respiratory journal 2006;28(6):1276-9.
2006: Rose M Viscardi; Sergei Atamas; Irina G Luzina; Jeffrey D Hasday; Ju-Ren He; Patricia J Sime; Jacqueline J Coalson; Bradley A Yoder
Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung.
Pediatric research 2006;60(2):141-6.
2006: Carolyn J Baglole; Seth M Bushinsky; Tatiana M Garcia; Aruna Kode; Irfan Rahman; Patricia J Sime; Richard P Phipps
Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.
American journal of physiology. Lung cellular and molecular physiology 2006;291(1):L19-29.
2006: Heather F Lakatos; Heather A Burgess; Thomas H Thatcher; Michelle R Redonnet; Eric Hernady; Jacqueline P Williams; Patricia J Sime
Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation.
Experimental lung research 2006;32(5):181-99.
2006: Carolyn J Baglole; Denise M Ray; Steven H Bernstein; Steven E Feldon; Terry Smith; Patricia J Sime; Richard P Phipps
More than structural cells, fibroblasts create and orchestrate the tumor microenvironment.
Immunological investigations 2006;35(3-4):297-325.
2005: Thomas H Thatcher; Patricia J Sime; Richard K Barth
Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire.
Experimental lung research 2005;31(7):685-700.
2005: Christine A Martey; Carolyn J Baglole; Thomas A Gasiewicz; Patricia J Sime; Richard P Phipps
The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.
American journal of physiology. Lung cellular and molecular physiology 2005;289(3):L391-9.
2005: Thomas H Thatcher; N A McHugh; Robert W Egan; R W Chapman; J A Hey; Chantal K Turner; M R Redonnet; Kathryn Seweryniak; Patricia J Sime; Richard P Phipps
Role of CXCR2 in cigarette smoke-induced lung inflammation.
American journal of physiology. Lung cellular and molecular physiology 2005;289(2):L322-8.
2005: Bruce A Vallance; M Imelda Gunawan; Bryan Hewlett; Premysl Bercik; Corinne Van Kampen; Francesca Galeazzi; Patricia J Sime; Jack Gauldie; Stephen Collins
TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(1):G116-28.
2005: Heather A Burgess; Louis Eugene Daugherty; Thomas H Thatcher; Heather F Lakatos; Denise M Ray; Michelle Redonnet; Richard P Phipps; Patricia J Sime
PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2005;288(6):L1146-53.
2005: Katherine M A O'Reilly; Richard P Phipps; Thomas H Thatcher; Beth A Graf; John Van Kirk; Patricia J Sime
Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2005;288(6):L1010-6.
2005: Carolyn J Baglole; Sireesha Y Reddy; Stephen J Pollock; Steven E Feldon; Patricia J Sime; Terry Smith; Richard P Phipps
Isolation and phenotypic characterization of lung fibroblasts.
Methods in molecular medicine 2005;117():115-27.
2004: Christine A Martey; Stephen J Pollock; Chantal K Turner; Katherine M A O'Reilly; Carolyn J Baglole; Richard P Phipps; Patricia J Sime
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
American journal of physiology. Lung cellular and molecular physiology 2004;287(5):L981-91.
2004: Chantal K Turner; Timothy M Blieden; Terry Smith; Steven E Feldon; David C Foster; Patricia J Sime; Richard P Phipps
A novel ELISpot method for adherent cells.
Journal of immunological methods 2004;291(1-2):63-70.
2004: Gunilla Westergren-Thorsson; Patricia J Sime; Manel Jordana; Jack Gauldie; Bengt Särnstrand; Anders Malmström
Lung fibroblast clones from normal and fibrotic subjects differ in hyaluronan and decorin production and rate of proliferation.
The international journal of biochemistry & cell biology 2004;36(8):1573-84.
2004: Derek A Pociask; Patricia J Sime; Arnold R Brody
Asbestos-derived reactive oxygen species activate TGF-beta1.
Laboratory investigation; a journal of technical methods and pathology 2004;84(8):1013-23.
2004: K M A O'Reilly; Joe Boscia; K L Kaplan; Patricia J Sime
A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis.
The European respiratory journal 2004;23(6):954-6.
2004: Julia Kaufman; Patricia J Sime; Richard P Phipps
Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1862-71.
2002: G Sakuntala Warshamana; Derek A Pociask; Patricia J Sime; David A Schwartz; Arnold R Brody
Susceptibility to asbestos-induced and transforming growth factor-beta1-induced fibroproliferative lung disease in two strains of mice.
American journal of respiratory cell and molecular biology 2002;27(6):705-13.
2002: G Sakuntala Warshamana; Derek A Pociask; Krishna J Fisher; Jing-Yao Liu; Patricia J Sime; Arnold R Brody
Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice.
International journal of experimental pathology 2002;83(4):183-201.
2002: Martin Kolb; Philippe Bonniaud; Tom Galt; Patricia J Sime; Margaret M Kelly; Peter J Margetts; Jack Gauldie
Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.
American journal of respiratory cell and molecular biology 2002;27(2):141-50.
2002: Jack Gauldie; Martin Kolb; Patricia J Sime
A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
Respiratory research 2002;3():1.
2001: Jing-Yao Liu; Patricia J Sime; T Wu; G Sakuntala Warshamana; Derek A Pociask; Shang-Yi Tsai; Arnold R Brody
Transforming growth factor-beta(1) overexpression in tumor necrosis factor-alpha receptor knockout mice induces fibroproliferative lung disease.
American journal of respiratory cell and molecular biology 2001;25(1):3-7.
2001: Patricia J Sime; K M O'Reilly
Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.
Clinical immunology (Orlando, Fla.) 2001;99(3):308-19.
2001: Martin Kolb; Peter J Margetts; Patricia J Sime; Jack Gauldie
Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung.
American journal of physiology. Lung cellular and molecular physiology 2001;280(6):L1327-34.
2001: Martin Kolb; Peter J Margetts; Tom Galt; Patricia J Sime; Zhou Xing; M Schmidt; Jack Gauldie
Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin.
American journal of respiratory and critical care medicine 2001;163(3 Pt 1):770-7.
1999: J Gauldie; Patricia J Sime; Zhou Xing; B Marr; G M Tremblay
Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis.
Current topics in pathology. Ergebnisse der Pathologie 1999;93():35-45.
1998: Martin R Stämpfli; Stacey A Ritz; G Scott Neigh; Patricia J Sime; XF Lei; Zhou Xing; Kenneth Croitoru; Manel Jordana
Adenoviral infection inhibits allergic airways inflammation in mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(12):1581-90.
1997: Patricia J Sime; Zhou Xing; Frank L Graham; K G Csaky; Jack Gauldie
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.
The Journal of clinical investigation 1997;100(4):768-76.
1997: Patricia J Sime; B Sarnstrand; Zhou Xing; F Graham; L Fisher; Jack Gauldie
Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung.
Chest 1997;111(6 Suppl):137S.
1997: Patricia J Sime; Zhou Xing; R Foley; F L Graham; Jack Gauldie
Transient gene transfer and expression in the lung.
Chest 1997;111(6 Suppl):89S-94S.
1997: Zhou Xing; G M Tremblay; Patricia J Sime; Jack Gauldie
Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.
The American journal of pathology 1997;150(1):59-66.
1996: Jack Gauldie; F Graham; Zhou Xing; Todd A Braciak; Ronan Foley; Patricia J Sime
Adenovirus-vector-mediated cytokine gene transfer to lung tissue.
Annals of the New York Academy of Sciences 1996;796():235-44.
1996: Zhou Xing; Todd A Braciak; Y Ohkawara; Jean-Michel Sallenave; Ronan Foley; Patricia J Sime; Manel Jordana; F L Graham; Jack Gauldie
Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation.
Journal of leukocyte biology 1996;59(4):481-8.
1995: Ruth N Kingshott; Patricia J Sime; Heather M Engleman; Neil J Douglas
Self assessment of daytime sleepiness: patient versus partner.
Thorax 1995;50(9):994-5.
1994: Manel Jordana; B Särnstrand; Patricia J Sime; I Ramis
Immune-inflammatory functions of fibroblasts.
The European respiratory journal 1994;7(12):2212-22.
1994: G C Priestley; R D Aldridge; Patricia J Sime; D Wilson
Skin fibroblast activity in pretibial myxoedema and the effect of octreotide (Sandostatin) in vitro.
The British journal of dermatology 1994;131(1):52-6.
1989: Patricia J Sime; A Gordon; M L Hooper; Jeanne E Bell
Differentiation in medulloblastomas and other primitive neuroectodermal tumours.
British journal of neurosurgery 1989;3(1):89-100.