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Anton Simeonov

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Publications

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Giang Huong Nguyen; Andrew S Rosenthal; Masaaki Sakurai; Pavel Savitsky; Lena Schultz; Anton Simeonov; Dharmendra Kumar Singh; Ajit Jadhav; David J Maloney; Peter J McHugh; Georgina Mosedale; Mika Abu; Csanád Z Bachrati; Vilhelm A Bohr; Wai Kit Chu; Thomas S Dexheimer; Opher Gileadi; Curtis C Harris; Ian D Hickson
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Jingbo Xiao; Wei Zheng; Marc Ferrer; Ehud Goldin; Ann Marie Gustafson; Xin Hu; Wendy A Lea; Ke Liu; Leslie Matalonga; Omid Motabar; Antonia Ribes; Ellen Sidransky; Anton Simeonov; Noel Southall; Rafael J Tamargo; Arash Velayati; Wendy Westbroek; Juan J Marugan
Discovery of a novel noniminosugar acid α glucosidase chaperone series.
Jessica R Weaver; Theodore R. Holman; Yumi Imai; Ajit Jadhav; victor kenyon; David J Maloney; Jerry L Nadler; Ganesha Rai; Anton Simeonov; David Taylor-Fishwick
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

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All Publications

2013: Giang Huong Nguyen; Andrew S Rosenthal; Masaaki Sakurai; Pavel Savitsky; Lena Schultz; Anton Simeonov; Dharmendra Kumar Singh; Ajit Jadhav; David J Maloney; Peter J McHugh; Georgina Mosedale; Mika Abu; Csanád Z Bachrati; Vilhelm A Bohr; Wai Kit Chu; Thomas S Dexheimer; Opher Gileadi; Curtis C Harris; Ian D Hickson
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Chemistry & biology 2013;20(1):55-62.
2012: Jingbo Xiao; Wei Zheng; Marc Ferrer; Ehud Goldin; Ann Marie Gustafson; Xin Hu; Wendy A Lea; Ke Liu; Leslie Matalonga; Omid Motabar; Antonia Ribes; Ellen Sidransky; Anton Simeonov; Noel Southall; Rafael J Tamargo; Arash Velayati; Wendy Westbroek; Juan J Marugan
Discovery of a novel noniminosugar acid α glucosidase chaperone series.
Journal of medicinal chemistry 2012;55(17):7546-59.
2012: Jessica R Weaver; Theodore R. Holman; Yumi Imai; Ajit Jadhav; victor kenyon; David J Maloney; Jerry L Nadler; Ganesha Rai; Anton Simeonov; David Taylor-Fishwick
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
Molecular and cellular endocrinology 2012;358(1):88-95.
2012: Ganesha Rai; Anton Simeonov; Vaddadi N Vyjayanti; David M Wilson; Dorjbal Dorjsuren; Ajit Jadhav; David J Maloney
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.
Journal of medicinal chemistry 2012;55(7):3101-12.
2012: Jennifer Yeung; Patrick L Apopa; Olivier Boutaud; Theodore R. Holman; Ajit Jadhav; victor kenyon; David J Maloney; Ganesha Rai; Anton Simeonov; Joanne Vesci; Michael Holinstat
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Molecular pharmacology 2012;81(3):420-30.
2012: Dorjbal Dorjsuren; Ajit Jadhav; Daemyung Kim; David J Maloney; Vaddadi N Vyjayanti; David M Wilson; Anton Simeonov
Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.
PloS one 2012;7(10):e47974.
2012: Kinrin Yamanaka; David J Maloney; Anton Simeonov; Dorjbal Dorjsuren; Martin Egli; Robert L Eoff; Ajit Jadhav; R Stephen Lloyd
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
PloS one 2012;7(10):e45032.
2012: Adam Yasgar; Silviya D Furdas; Ajit Jadhav; Manfred Jung; David J Maloney; Anton Simeonov
High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.
PloS one 2012;7(9):e45594.
2012: Wendy A Lea; Anton Simeonov
Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.
PloS one 2012;7(4):e36219.
2011: Junjun Chen; Thomas S Dexheimer; James Inglese; Ajit Jadhav; Qin Liang; David J Maloney; Anton Simeonov; Mark A Villamil; Yongxing Ai; Zhihao Zhuang
Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.
Chemistry & biology 2011;18(11):1390-400.
2011: victor kenyon; William Leister; David J Maloney; Jerry L Nadler; Steven Perry; Ganesha Rai; Lena Schultz; Anton Simeonov; David A Taylor-Fishwick; Michelle Armstrong; James M Bougie; Michael Holinstat; Ajit Jadhav; J Brian Jameson; Netra Joshi; Theodore R. Holman
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Journal of medicinal chemistry 2011;54(15):5485-97.
2011: Rajarshi Guha; Ajit Jadhav; Aimee N Kestranek; Gregory P Roth; Anton Simeonov; Andrew M Chervenak; Thomas S Dexheimer; Michael G Ford; Craig J Thomas
Exploratory analysis of kinetic solubility measurements of a small molecule library.
Bioorganic & medicinal chemistry 2011;19(13):4127-34.
2011: Stefanie Prast-Nielsen; Thomas S Dexheimer; Lena Schultz; William C Stafford; Qing Cheng; Jianqiang Xu; Ajit Jadhav; Elias Arnér; Anton Simeonov
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Free radical biology & medicine 2011;50(9):1114-23.
2011: Juan J Marugan; Wei Zheng; Omid Motabar; Noel Southall; Ehud Goldin; Wendy Westbroek; Barbara K Stubblefield; Ellen Sidransky; Ronald A Aungst; Wendy A Lea; Anton Simeonov; William Leister; Christopher P Austin
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
Journal of medicinal chemistry 2011;54(4):1033-58.
2011: Wendy A Lea; Anton Simeonov
Fluorescence polarization assays in small molecule screening.
Expert opinion on drug discovery 2011;6(1):17-32.
2011: Amy M Quinn; Anton Simeonov
Methods for Activity Analysis of the Proteins that Regulate Histone Methylation.
Current chemical genomics 2011;5(Suppl 1):95-105.
2011: Dorjbal Dorjsuren; Daemyung Kim; David J Maloney; David M Wilson; Anton Simeonov
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.
Nucleic acids research 2011;39(2):e11.
2010: Ganesha Rai; victor kenyon; Ajit Jadhav; Lena Schultz; Michelle Armstrong; J Brian Jameson; Eric Hoobler; William Leister; Anton Simeonov; Theodore R Holman; David J Maloney
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Journal of medicinal chemistry 2010;53(20):7392-404.
2010: Amy M Quinn; Abdellah Allali-Hassani; Masoud Vedadi; Anton Simeonov
A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.
Molecular bioSystems 2010;6(5):782-8.
2010: Adam Yasgar; John Shultz; Wenhui Zhou; Hui Wang; Fen Huang; Nancy Murphy; Erika L Abel; John DiGiovanni; James Inglese; Anton Simeonov
A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity.
Assay and drug development technologies 2010;8(2):200-11.
2010: Douglas S Auld; Scott Lovell; Natasha Thorne; Wendy A Lea; David J Maloney; Min Shen; Ganesha Rai; Kevin P Battaile; Craig J Thomas; Anton Simeonov; Robert P Hanzlik; James Inglese
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4878-83.
2010: Adam Yasgar; Timothy L Foley; Ajit Jadhav; James Inglese; Michael D Burkart; Anton Simeonov
A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase.
Molecular bioSystems 2010;6(2):365-75.
2010: Masaaki Sakurai; Nathan R Rose; Lena Schultz; Amy M Quinn; Ajit Jadhav; Stanley S Ng; Udo Oppermann; Christopher J Schofield; Anton Simeonov
A miniaturized screen for inhibitors of Jumonji histone demethylases.
Molecular bioSystems 2010;6(2):357-64.
2010: Bryan T Mott; Rafaela S Ferreira; Anton Simeonov; Ajit Jadhav; Kenny Kean-Hooi Ang; William Leister; Min Shen; Julia T Silveira; Patricia S Doyle; Michelle R Arkin; James H McKerrow; James Inglese; Christopher P Austin; Craig J Thomas; Brian Shoichet; David J Maloney
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Journal of medicinal chemistry 2010;53(1):52-60.
2010: Ajit Jadhav; Rafaela S Ferreira; Carleen Klumpp; Bryan T Mott; Christopher P Austin; James Inglese; Craig J Thomas; David J Maloney; Brian Shoichet; Anton Simeonov
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
Journal of medicinal chemistry 2010;53(1):37-51.
2010: Amy M Quinn; Mark T Bedford; Alexsandra Espejo; Astrid Spannhoff; Christopher P Austin; Udo Oppermann; Anton Simeonov
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.
Nucleic acids research 2010;38(2):e11.
2009: Ganesha Rai; Ahmed A Sayed; Wendy A Lea; Hans F Luecke; Harinath Chakrapani; Stefanie Prast-Nielsen; Ajit Jadhav; William Leister; Min Shen; James Inglese; Christopher P Austin; Larry Keefer; Elias Arnér; Anton Simeonov; David J Maloney; David L Williams; Craig J Thomas
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
Journal of medicinal chemistry 2009;52(20):6474-83.
2009: Dorjbal Dorjsuren; David M Wilson; William A Beard; John P McDonald; Christopher P Austin; Roger Woodgate; Samuel H Wilson; Anton Simeonov
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases.
Nucleic acids research 2009;37(19):e128.
2009: Sunita J Shukla; Dac-Trung Nguyen; Ryan Macarthur; Anton Simeonov; William J Frazee; Tina M Hallis; Bryan D Marks; Upinder Singh; Hildegard C Eliason; John Printen; Christopher P Austin; James Inglese; Douglas S Auld
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.
Assay and drug development technologies 2009;7(2):143-69.
2009: Craig J Thomas; Douglas S Auld; Ruili Huang; Wenwei Huang; Ajit Jadhav; Ronald L Johnson; William Leister; David J Maloney; Juan J Marugan; Sam Michael; Anton Simeonov; Noel Southall; Menghang Xia; Wei Zheng; James Inglese; Christopher P Austin
The pilot phase of the NIH Chemical Genomics Center.
Current topics in medicinal chemistry 2009;9(13):1181-93.
2009: Wendy A Lea; Jin Xi; Ajit Jadhav; Louis Lu; Christopher P Austin; Anton Simeonov; Roderic G Eckenhoff
A high-throughput approach for identification of novel general anesthetics.
PloS one 2009;4(9):e7150.
2009: Anton Simeonov; Avanti Kulkarni; Dorjbal Dorjsuren; Ajit Jadhav; Min Shen; Daniel R McNeill; Christopher P Austin; David M Wilson
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.
PloS one 2009;4(6):e5740.
2009: Christophe Marchand; Wendy A Lea; Ajit Jadhav; Thomas S Dexheimer; Christopher P Austin; James Inglese; Yves Pommier; Anton Simeonov
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.
Molecular cancer therapeutics 2009;8(1):240-8.
2008: Sam Michael; Douglas S Auld; Carleen Klumpp; Ajit Jadhav; Wei Zheng; Natasha Thorne; Christopher P Austin; James Inglese; Anton Simeonov
A robotic platform for quantitative high-throughput screening.
Assay and drug development technologies 2008;6(5):637-57.
2008: Wendy A Lea; Ajit Jadhav; Ganesha Rai; Ahmed A Sayed; Cynthia L Cass; James Inglese; David L Williams; Christopher P Austin; Anton Simeonov
A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.
Assay and drug development technologies 2008;6(4):551-5.
2008: Adam Jordan Kimple; Adam Yasgar; Mark Hughes; Ajit Jadhav; Francis S Willard; Robin E Muller; Christopher P Austin; James Inglese; Gordon C Ibeanu; David Siderovski; Anton Simeonov
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.
Combinatorial chemistry & high throughput screening 2008;11(5):396-409.
2008: Douglas S Auld; Noel Southall; Ajit Jadhav; Ronald L Johnson; David J Diller; Anton Simeonov; Christopher P Austin; James Inglese
Characterization of chemical libraries for luciferase inhibitory activity.
Journal of medicinal chemistry 2008;51(8):2372-86.
2008: Anton Simeonov; Ajit Jadhav; Craig J Thomas; Yuhong Wang; Ruili Huang; Noel Southall; Paul Shinn; Jeremy Smith; Christopher P Austin; Douglas S Auld; James Inglese
Fluorescence spectroscopic profiling of compound libraries.
Journal of medicinal chemistry 2008;51(8):2363-71.
2008: Kerim Babaoglu; Anton Simeonov; John J Irwin; Michael E Nelson; Brian Feng; Craig J Thomas; Laura Cancian; M Paola Costi; David A Maltby; Ajit Jadhav; James Inglese; Christopher P Austin; Brian Shoichet
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
Journal of medicinal chemistry 2008;51(8):2502-11.
2008: Anton Simeonov; Adam Yasgar; Ajit Jadhav; G L Lokesh; Carleen Klumpp; Sam Michael; Christopher P Austin; Amarnath Natarajan; James Inglese
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction.
Analytical biochemistry 2008;375(1):60-70.
2008: Anton Simeonov; Ajit Jadhav; Ahmed A Sayed; Yuhong Wang; Michael E Nelson; Craig J Thomas; James Inglese; David L Williams; Christopher P Austin
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.
PLoS neglected tropical diseases 2008;2(1):e127.
2007: Anton Simeonov; Adam Yasgar; Carleen Klumpp; Wei Zheng; Naeem Shafqat; Udo Oppermann; Christopher P Austin; James Inglese
Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.
Assay and drug development technologies 2007;5(6):815-24.
2007: Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas S Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13192-7.
2007: James Inglese; Ronald L Johnson; Anton Simeonov; Menghang Xia; Wei Zheng; Christopher P Austin; Douglas S Auld
High-throughput screening assays for the identification of chemical probes.
Nature chemical biology 2007;3(8):466-79.
2007: Brian Y Feng; Anton Simeonov; Ajit Jadhav; Kerim Babaoglu; James Inglese; Brian Shoichet; Christopher P Austin
A high-throughput screen for aggregation-based inhibition in a large compound library.
Journal of medicinal chemistry 2007;50(10):2385-90.
2006: James Inglese; Douglas S Auld; Ajit Jadhav; Ronald L Johnson; Anton Simeonov; Adam Yasgar; Wei Zheng; Christopher P Austin
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11473-8.
2006: Douglas S Auld; Ronald L Johnson; Ya-qin Zhang; Henrike Veith; Ajit Jadhav; Adam Yasgar; Anton Simeonov; Wei Zheng; Elisabeth D Martinez; John K Westwick; Christopher P Austin; James Inglese
Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.
Methods in enzymology 2006;414():566-89.