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Maria Simile

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Maddalena Frau; Gavinella Latte; Stefania Brozzetti; Diego F Calvisi; Lucia Daino; Maria I Demartis; Claudio F Feo; Francesco Feo; Fabiana Salis; Maria A Seddaiu; Maria M Simile; Giuliana Solinas; Maria L Tomasi; Toshikazu Ushijima; Satoshi Yamashita; Rosa M Pascale
Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
Maddalena Frau; Ju Seog Lee; Giovanni Massarelli; Stefania Brozzetti; Lucia Daino; Maria I Demartis; Claudio F Feo; Francesco Feo; Maria A Seddaiu; Maria M Simile; Giuliana Solinas; Maria L Tomasi; Rosa M Pascale
An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis.
Maddalena Frau; Sara Ladu; Maria A Seddaiu; Maria M Simile; Maria L Tomasi; Piero Bonelli; Diego F Calvisi; Lucia Daino; Francesco Feo; Rosa M Pascale
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.

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All Publications

2012: Maddalena Frau; Gavinella Latte; Stefania Brozzetti; Diego F Calvisi; Lucia Daino; Maria I Demartis; Claudio F Feo; Francesco Feo; Fabiana Salis; Maria A Seddaiu; Maria M Simile; Giuliana Solinas; Maria L Tomasi; Toshikazu Ushijima; Satoshi Yamashita; Rosa M Pascale
Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
Hepatology (Baltimore, Md.) 2012;56(1):165-75.
2012: Maddalena Frau; Ju Seog Lee; Giovanni Massarelli; Stefania Brozzetti; Lucia Daino; Maria I Demartis; Claudio F Feo; Francesco Feo; Maria A Seddaiu; Maria M Simile; Giuliana Solinas; Maria L Tomasi; Rosa M Pascale
An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis.
Cellular oncology (Dordrecht) 2012;35(3):163-73.
2011: Maddalena Frau; Sara Ladu; Maria A Seddaiu; Maria M Simile; Maria L Tomasi; Piero Bonelli; Diego F Calvisi; Lucia Daino; Francesco Feo; Rosa M Pascale
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Journal of hepatology 2011;55(1):111-9.
2011: Diego F Calvisi; Maria M Simile; Sara Ladu; Maddalena Frau; Matthias Evert; Maria L Tomasi; Maria I Demartis; Lucia Daino; Maria A Seddaiu; Stefania Brozzetti; Francesco Feo; Rosa M Pascale
Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
Hepatology (Baltimore, Md.) 2011;53(4):1226-36.
2010: Diego F Calvisi; Federico Pinna; Sara Ladu; Maria R Muroni; Maddalena Frau; Ilaria Demartis; Maria L Tomasi; Marcella Sini; Maria M Simile; Maria A Seddaiu; Francesco Feo; Rosa M Pascale
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
International journal of cancer. Journal international du cancer 2010;126(5):1275-81.
2009: Diego F Calvisi; Sara Ladu; Federico Pinna; Maddalena Frau; Maria L Tomasi; Marcella Sini; Maria M Simile; Piero Bonelli; Maria R Muroni; Maria A Seddaiu; Dae-Sik Lim; Francesco Feo; Rosa M Pascale
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Gastroenterology 2009;137(5):1816-26.e1-10.
2009: Diego F Calvisi; Federico Pinna; Sara Ladu; R Pellegrino; Maria M Simile; Maddalena Frau; Maria R De Miglio; M L Tomasi; Vanna Sanna; Maria R Muroni; Francesco Feo; Rosa M Pascale
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.
Gut 2009;58(5):679-87.
2008: Diego F Calvisi; Federico Pinna; Rossella Pellegrino; Valeria Sanna; Marcella Sini; Lucia Daino; Maria M Simile; Maria R De Miglio; Maddalena Frau; Maria L Tomasi; Maria A Seddaiu; Maria R Muroni; Francesco Feo; Rosa M Pascale
Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control.
International journal of cancer. Journal international du cancer 2008;123(9):2057-64.
2008: Diego F Calvisi; Federico Pinna; Sara Ladu; Rossella Pellegrino; Maria R Muroni; Maria M Simile; Maddalena Frau; Maria L Tomasi; Maria R De Miglio; Maria A Seddaiu; Lucia Daino; Valeria Sanna; Francesco Feo; Rosa M Pascale
Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease.
Carcinogenesis 2008;29(8):1639-47.
2008: Diego F Calvisi; Federico Pinna; Floriana Meloni; Sara Ladu; Rossella Pellegrino; Marcella Sini; Lucia Daino; Maria M Simile; Maria R De Miglio; Patrizia Virdis; Maddalena Frau; Maria L Tomasi; Maria A Seddaiu; Maria R Muroni; Francesco Feo; Rosa M Pascale
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.
Cancer research 2008;68(11):4192-200.
2007: Diego F Calvisi; Maria M Simile; Sara Ladu; Rossella Pellegrino; Valentina De Murtas; Federico Pinna; Maria L Tomasi; Maddalena Frau; Patrizia Virdis; Maria R De Miglio; Maria R Muroni; Rosa M Pascale; Francesco Feo
Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis.
International journal of cancer. Journal international du cancer 2007;121(11):2410-20.
2007: Maria R De Miglio; Patrizia Virdis; Diego F Calvisi; Daniela Mele; Maria R Muroni; Maddalena Frau; Federico Pinna; Maria L Tomasi; Maria M Simile; Rosa M Pascale; Francesco Feo
Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat.
Carcinogenesis 2007;28(11):2367-74.
2006: Maria R De Miglio; Patrizia Virdis; Diego F Calvisi; Maddalena Frau; Maria R Muroni; Maria M Simile; Lucia Daino; Gian Mario Careddu; Eraldo Sanna-Passino; Rosa M Pascale; Francesco Feo
Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat.
Cancer research 2006;66(21):10384-90.
2006: Francesco Feo; Maria R De Miglio; Maria M Simile; Maria R Muroni; Diego F Calvisi; Maddalena Frau; Rosa M Pascale
Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.
Biochimica et biophysica acta 2006;1765(2):126-47.
2005: Rosa M Pascale; Maria M Simile; Diego F Calvisi; Maddalena Frau; Maria R Muroni; Maria A Seddaiu; Lucia Daino; Maria D Muntoni; Maria R De Miglio; Snorri S Thorgeirsson; Francesco Feo
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Hepatology (Baltimore, Md.) 2005;42(6):1310-9.
2005: Maria M Simile; Gabriella Pagnan; Fabio Pastorino; Chiara Brignole; Maria R De Miglio; Maria R Muroni; Giuseppina Asara; Maddalena Frau; Maria A Seddaiu; Diego F Calvisi; Francesco Feo; Mirco Ponzoni; Rosa M Pascale
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.
Carcinogenesis 2005;26(2):417-27.
2004: Maria R De Miglio; Rosa M Pascale; Maria M Simile; Maria R Muroni; Patrizia Virdis; Kelvin M-T Kwong; Leslie K L Wong; Giovanni M Bosinco; Franca R Pulina; Diego F Calvisi; Maddalena Frau; Geoffrey A Wood; Michael C Archer; Francesco Feo
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats.
International journal of cancer. Journal international du cancer 2004;111(1):9-16.
2004: Maria M Simile; Maria R De Miglio; Maria R Muroni; Maddalena Frau; Giuseppina Asara; Silvia Serra; Maria D Muntoni; Maria A Seddaiu; Lucia Daino; Francesco Feo; Rosa M Pascale
Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells.
Carcinogenesis 2004;25(3):333-41.
2003: Maria R De Miglio; Maria M Simile; Maria R Muroni; Diego F Calvisi; Patrizia Virdis; Giuseppina Asara; Maddalena Frau; Giovanni M Bosinco; Maria A Seddaiu; Lucia Daino; Francesco Feo; Rosa M Pascale
Phenotypic reversion of rat neoplastic liver nodules is under genetic control.
International journal of cancer. Journal international du cancer 2003;105(1):70-5.
2002: F Stefania Falvella; Rosa M Pascale; manuela gariboldi; Giacomo Manenti; Maria R De Miglio; Maria M Simile; Tommaso A Dragani; Francesco Feo
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.
Carcinogenesis 2002;23(11):1933-6.
2002: Maria R De Miglio; Rosa M Pascale; Maria M Simile; Maria R Muroni; Diego F Calvisi; Patrizia Virdis; Giovanni M Bosinco; Maddalena Frau; Maria A Seddaiu; Sara Ladu; Francesco Feo
Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis.
Cancer research 2002;62(15):4459-63.
2002: Rosa M Pascale; Maria M Simile; Maria R De Miglio; Francesco Feo
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
Alcohol (Fayetteville, N.Y.) 2002;27(3):193-8.
2002: Rosa M Pascale; Maria M Simile; Maria R De Miglio; Maria R Muroni; Diego F Calvisi; Giuseppina Asara; Daniela Casabona; Maddalena Frau; Maria A Seddaiu; Francesco Feo
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2002;35(6):1341-50.
2001: Maria R De Miglio; Maria R Muroni; Maria M Simile; Patrizia Virdis; Giuseppina Asara; Maddalena Frau; Diego F Calvisi; Maria A Seddaiu; Rosa M Pascale; Francesco Feo
Frequent loss of heterozygosity at the Hcr1 (hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain.
Hepatology (Baltimore, Md.) 2001;33(5):1110-7.
2001: Maria M Simile; Sebastiano Banni; Elisabetta Angioni; Gianfranca Carta; Maria R De Miglio; Maria R Muroni; Diego F Calvisi; A Carru; Rosa M Pascale; Francesco Feo
5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.
Journal of hepatology 2001;34(3):386-94.
2001: Maria M Simile; Maria R De Miglio; Diego F Calvisi; Maria R Muroni; Maddalena Frau; Giuseppina Asara; Lucia Daino; L Deiana; Rosa M Pascale; Francesco Feo
Long-term dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats.
Carcinogenesis 2001;22(2):301-8.
2000: Maria R De Miglio; Maria R Muroni; Maria M Simile; Diego F Calvisi; P Tolu; L Deiana; A Carru; G Bonelli; Francesco Feo; Rosa M Pascale
Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions.
Hepatology (Baltimore, Md.) 2000;31(4):956-65.
2000: Francesco Feo; Rosa M Pascale; Maria M Simile; Maria R De Miglio; Maria R Muroni; Diego F Calvisi
Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies.
Critical reviews in oncogenesis 2000;11(1):19-62.
1999: Maria R De Miglio; F Canzian; Rosa M Pascale; Maria M Simile; Maria R Muroni; Diego F Calvisi; G Romeo; Francesco Feo
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.
Cancer research 1999;59(18):4651-7.
1999: Maria R De Miglio; Maria M Simile; Maria R Muroni; S Pusceddu; Diego F Calvisi; A Carru; Maria A Seddaiu; Lucia Daino; L Deiana; Rosa M Pascale; Francesco Feo
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Molecular carcinogenesis 1999;25(1):21-9.
1998: Rosa M Pascale; Maria R De Miglio; Maria R Muroni; Maria M Simile; Lucia Daino; Maria A Seddaiu; S Pusceddu; Leonardo Gaspa; Diego F Calvisi; Giacomo Manenti; Francesco Feo
Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat.
Hepatology (Baltimore, Md.) 1998;27(2):452-61.
1996: Rosa M Pascale; Maria R De Miglio; Maria R Muroni; Maria M Simile; Lucia Daino; Maria A Seddaiu; A Nufris; Leonardo Gaspa; Luca Deiana; Francesco Feo
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model.
International journal of cancer. Journal international du cancer 1996;68(1):136-42.
1996: Rosa M Pascale; Maria M Simile; M R DeMiglio; Maria R Muroni; Leonardo Gaspa; T A Dragani; Francesco Feo
The BN rat strain carries dominant hepatocarcinogen resistance loci.
Carcinogenesis 1996;17(8):1765-8.
1996: Maria M Simile; M Saviozzi; Maria R De Miglio; Maria R Muroni; A Nufris; Rosa M Pascale; G Malvaldi; Francesco Feo
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats.
Carcinogenesis 1996;17(7):1533-7.
1995: Maria M Simile; Rosa M Pascale; Maria R De Miglio; A Nufris; Lucia Daino; Maria A Seddaiu; Maria R Muroni; K N Rao; Francesco Feo
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis.
International journal of cancer. Journal international du cancer 1995;62(2):210-5.
1995: Rosa M Pascale; Maria M Simile; Maria R De Miglio; A Nufris; Maria A Seddaiu; Maria R Muroni; O Danni; K N Rao; Francesco Feo
Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneoplastic liver nodules.
Carcinogenesis 1995;16(7):1537-42.
1995: Rosa M Pascale; Maria M Simile; Maria R De Miglio; A Nufris; Lucia Daino; Maria A Seddaiu; P M Rao; Srinivasan Rajalakshmi; D S Sarma; Francesco Feo
Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid.
Carcinogenesis 1995;16(2):427-30.
1994: Maria M Simile; Rosa M Pascale; Maria R De Miglio; A Nufris; Lucia Daino; Maria A Seddaiu; Leonardo Gaspa; Francesco Feo
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Cancer letters 1994;79(1):9-16.
1993: U Gerbracht; Erich Eigenbrodt; Maria M Simile; Rosa M Pascale; Leonardo Gaspa; Lucia Daino; Maria A Seddaiu; Maria R De Miglio; A Nufris; Francesco Feo
Effect of S-adenosyl-L-methionine on the development of preneoplastic foci and the activity of some carbohydrate metabolizing enzymes in the liver, during experimental hepatocarcinogenesis.
Anticancer research 1993;13(6A):1965-72.
1993: Rosa M Pascale; Maria M Simile; Francesco Feo
Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy.
Anticancer research 1993;13(5A):1341-56.
1993: Maria M Simile; M R DeMiglio; A Nufris; Rosa M Pascale; Maria R Muroni; Francesco Feo
l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate doses.
Research communications in chemical pathology and pharmacology 1993;81(2):251-4.
1993: Rosa M Pascale; Maria M Simile; Leonardo Gaspa; Lucia Daino; Maria A Seddaiu; G Pinna; M Carta; P Zolo; Francesco Feo
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis.
Carcinogenesis 1993;14(5):1077-80.
1993: Rosa M Pascale; Maria M Simile; Maria A Seddaiu; Lucia Daino; M A Vinci; G Pinna; S Bennati; Leonardo Gaspa; Francesco Feo
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: is DNA methylation involved?
Basic life sciences 1993;61():219-37.
1992: Rosa M Pascale; Vincenzo Marras; Maria M Simile; Lucia Daino; G Pinna; S Bennati; M Carta; Maria A Seddaiu; Giovanni Massarelli; Francesco Feo
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study.
Cancer research 1992;52(18):4979-86.
1991: Francesco Feo; Lucia Daino; Maria A Seddaiu; Maria M Simile; Rosa M Pascale; J A McKeating; G P Davliakos; K S Sudol; M F Melhem; K N Rao
Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats.
Carcinogenesis 1991;12(9):1581-6.
1991: Rosa M Pascale; Maria M Simile; G Satta; Maria A Seddaiu; Lucia Daino; G Pinna; M A Vinci; Leonardo Gaspa; Francesco Feo
Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis.
Anticancer research 1991;11(4):1617-24.
1991: Rosa M Pascale; Maria M Simile; M E Ruggiu; Maria A Seddaiu; G Satta; M J Sequenza; Lucia Daino; M G Vannini; P Lai; Francesco Feo
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
Cancer letters 1991;56(3):259-65.
1990: Rosa M Pascale; M E Ruggiu; Maria M Simile; Lucia Daino; G Vannini; Maria A Seddaiu; G Satta; Francesco Feo
Dependence of benzo(a)pyrene metabolism on NADPH pool in normal and glucose-6-phosphate dehydrogenase deficient human fibroblasts.
Research communications in chemical pathology and pharmacology 1990;69(3):361-4.
1989: R Garcea; Lucia Daino; Rosa M Pascale; Maria M Simile; M Puddu; M E Ruggiu; Maria A Seddaiu; G Satta; M J Sequenza; Francesco Feo
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio.
Carcinogenesis 1989;10(7):1183-92.
1989: R Garcea; Lucia Daino; Rosa M Pascale; Maria M Simile; M Puddu; S Frassetto; P Cozzolino; Maria A Seddaiu; Leonardo Gaspa; Francesco Feo
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
Cancer research 1989;49(7):1850-6.
1988: R Garcea; Lucia Daino; S Frassetto; P Cozzolino; M E Ruggiu; M G Vannini; Rosa M Pascale; L Lenzerini; Maria M Simile; M Puddu
Reversal by ribo- and deoxyribonucleosides of dehydroepiandrosterone-induced inhibition of enzyme altered foci in the liver of rats subjected to the initiation--selection process of experimental carcinogenesis.
Carcinogenesis 1988;9(6):931-8.