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Katherine Siminovitch

Research Profile

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TOP 3
Qin Wang; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
Gideon M Hirschfield; Xiangdong Liu; Younghun Han; Ivan P Gorlov; Yan Lu; Chun Xu; Yue Lu; Wei Chen; Brian D Juran; Catalina Coltescu; Andrew L Mason; Piotr Milkiewicz; Robert P Myers; Joseph A Odin; Velimir A Luketic; Danute Speiciene; Catherine Vincent; Cynthia Levy; Peter K Gregersen; Jinyi Zhang; E Jenny Heathcote; Konstantinos N Lazaridis; Christopher I Amos; Katherine A Siminovitch
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
Carole L Galligan; Katherine A Siminovitch; Edward C Keystone; Vivian Bykerk; Omar D Perez; Eleanor N Fish
Fibrocyte activation in rheumatoid arthritis.

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All Publications

2013: Qin Wang; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
The Biochemical journal 2013;449(3):771-82.
2010: Gideon M Hirschfield; Xiangdong Liu; Younghun Han; Ivan P Gorlov; Yan Lu; Chun Xu; Yue Lu; Wei Chen; Brian D Juran; Catalina Coltescu; Andrew L Mason; Piotr Milkiewicz; Robert P Myers; Joseph A Odin; Velimir A Luketic; Danute Speiciene; Catherine Vincent; Cynthia Levy; Peter K Gregersen; Jinyi Zhang; E Jenny Heathcote; Konstantinos N Lazaridis; Christopher I Amos; Katherine A Siminovitch
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
Nature genetics 2010;42(8):655-7.
2010: Carole L Galligan; Katherine A Siminovitch; Edward C Keystone; Vivian Bykerk; Omar D Perez; Eleanor N Fish
Fibrocyte activation in rheumatoid arthritis.
Rheumatology (Oxford, England) 2010;49(4):640-51.
2009: Jinyi Zhang; Baoxia Dong; Katherine A Siminovitch
Contributions of Wiskott-Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation.
Immunological reviews 2009;232(1):175-94.
2009: Qin Wang; Dhaarmini Rajshankar; Donald R Branch; Katherine A Siminovitch; Maria Teresa Herrera Abreu; Gregory P Downey; Christopher A McCulloch
Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.
The Journal of biological chemistry 2009;284(31):20763-72.
2009: Gideon M Hirschfield; Xiangdong Liu; Chun Xu; Yue Lu; Gang Xie; Yan Lu; Xiangjun Gu; Erin J Walker; Kaiyan Jing; Brian D Juran; Andrew L Mason; Robert P Myers; Kevork M Peltekian; Cameron N Ghent; Catalina Coltescu; Elizabeth J Atkinson; E Jenny Heathcote; Konstantinos N Lazaridis; Christopher I Amos; Katherine A Siminovitch
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
The New England journal of medicine 2009;360(24):2544-55.
2009: William G Newman; Qing Zhang; Xiangdong Liu; Christopher I Amos; Katherine A Siminovitch
Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population.
Journal of clinical gastroenterology 2009;43(5):444-7.
2009: Yongquan Shi; Jinyi Zhang; Michael Mullin; Baoxia Dong; ARTHUR S ALBERTS; Katherine A Siminovitch
The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3837-45.
2009: Robert K Nam; William W Zhang; John Trachtenberg; Arun Seth; Laurence H Klotz; Aleksandra Stanimirovic; Sanoj Punnen; Vasundara Venkateswaran; Ants Toi; D Andrew Loblaw; Linda Sugar; Katherine A Siminovitch; Steven A Narod
Utility of incorporating genetic variants for the early detection of prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1787-93.
2009: Yongquan Shi; Baoxia Dong; Helen Miliotis; Junye Liu; ARTHUR S ALBERTS; Jinyi Zhang; Katherine A Siminovitch
Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2009;87(1):207-16.
2009: Carole L Galligan; Janet C Siebert; Katherine A Siminovitch; Edward C Keystone; Vivian P Bykerk; Omar D Perez; Eleanor N Fish
Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy.
PloS one 2009;4(8):e6703.
2008: William G Newman; Jill Clayton-Smith; Kay Metcalfe; Rachel Cole; Marco Tartaglia; Francesco Brancati; Sara Morara; Antonio Novelli; Xiangdong Liu; Katherine A Siminovitch; Stefan Mundlos; May Tassabehji; Graeme C M Black
Geroderma osteodysplastica maps to a 4 Mb locus on chromosome 1q24.
American journal of medical genetics. Part A 2008;146A(23):3034-7.
2008: Miles D Thompson; Katherine A Siminovitch; David E C Cole
G protein-coupled receptor pharmacogenetics.
Methods in molecular biology (Clifton, N.J.) 2008;448():139-85.
2008: Robert K Nam; William W Zhang; D Andrew Loblaw; Laurence H Klotz; John Trachtenberg; Michael A S Jewett; A Stanimirovic; T O Davies; Ants Toi; Vasundara Venkateswaran; Linda Sugar; Katherine A Siminovitch; Steven A Narod
A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer.
Prostate cancer and prostatic diseases 2008;11(3):241-6.
2007: Chunjie Wang; Roya Navab; Vladimir Iakovlev; Yan Leng; Jinyi Zhang; Ming Tsao; Katherine A Siminovitch; David R McCready; Susan J Done
Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion.
Molecular cancer research : MCR 2007;5(10):1031-9.
2007: Erin J Walker; Katherine A Siminovitch
Primer: genomic and proteomic tools for the molecular dissection of disease.
Nature clinical practice. Rheumatology 2007;3(10):580-9.
2007: Kathryn M Eisenmann; Richard A West; Dagmar Hildebrand; Susan M Kitchen; Jun Peng; Robert Sigler; Jinyi Zhang; Katherine A Siminovitch; ARTHUR S ALBERTS
T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice.
The Journal of biological chemistry 2007;282(34):25152-8.
2007: Miles D Thompson; Valérie Capra; Jun Takasaki; Giovanna Maresca; G Enrico Rovati; Arthur Slutsky; Craig Lilly; Noe Zamel; W McIntyre Burnham; David E C Cole; Katherine A Siminovitch
A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate.
Pharmacogenetics and genomics 2007;17(7):539-49.
2007: Francisco H J Yun; Betty Y L Wong; Maretta Chase; Andrew Y Shuen; Lucie Canaff; Kansuda Thongthai; Katherine A Siminovitch; Geoffrey N Hendy; David E C Cole
Genetic variation at the calcium-sensing receptor (CASR) locus: implications for clinical molecular diagnostics.
Clinical biochemistry 2007;40(8):551-61.
2007: Karen Badour; Mary K H McGavin; Jinyi Zhang; Spencer Alexander Freeman; Claudia Vieira; Dominik Filipp; Michael Julius; Gordon B Mills; Katherine A Siminovitch
Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1593-8.
2007: Miguel A de la Fuente; Yoji Sasahara; Marco Calamito; Inés M Antón; Abdallah Elkhal; Maria D Gallego; Suresh Koduru; Katherine A Siminovitch; Hans D Ochs; Kenneth C Anderson; Fred S Rosen; Raif S Geha; Narayanaswamy Ramesh
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):926-31.
2007: Christopher I Amos; Wei Vivien Chen; Elaine F Remmers; Katherine A Siminovitch; Michael F Seldin; Lindsey A Criswell; Annette T Lee; Sally John; Neil D Shephard; Jane Worthington; Francois Cornelis; Robert M Plenge; Ann B Begovich; Thomas D Dyer; Daniel Kastner; Peter K Gregersen
Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits.
BMC proceedings 2007;1 Suppl 1():S3.
2007: Lily I Pao; Karen Badour; Katherine A Siminovitch; Benjamin G Neel
Nonreceptor protein-tyrosine phosphatases in immune cell signaling.
Annual review of immunology 2007;25():473-523.
2006: William G Newman; Qing Zhang; Xiangdong Liu; Erin Walker; Heather Ternan; Julie Owen; Ben Johnson; Wenda Greer; Dianne P Mosher; Walter P Maksymowych; Vivian P Bykerk; Edward C Keystone; Christopher I Amos; Katherine A Siminovitch
Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.
Arthritis and rheumatism 2006;54(12):3820-7.
2006: Judith Therrien; Sherryn Rambihar; Bill Newman; Katherine A Siminovitch; David Langleben; Gary Webb; John T Granton
Eisenmenger syndrome and atrial septal defect: nature or nurture?
The Canadian journal of cardiology 2006;22(13):1133-6.
2006: Robert K Nam; William W Zhang; Laurence H Klotz; John Trachtenberg; Michael A S Jewett; Joan Sweet; Ants Toi; Seamus Teahan; Vasundara Venkateswaran; Linda Sugar; Andrew Loblaw; Katherine A Siminovitch; Steven A Narod
Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6452-8.
2006: Qin Wang; Maria Teresa Herrera-Abreu; Katherine A Siminovitch; Gregory P Downey; Christopher A McCulloch
Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.
The Journal of biological chemistry 2006;281(41):31093-105.
2006: Mario E Beiner; Barry Rosen; Anthony Fyles; Ian Harley; Tuya Pal; Katherine A Siminovitch; Shiyu Zhang; Ping Sun; Steven A Narod
Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(9):1636-40.
2006: Katherine A Siminovitch
Advances in the molecular dissection of inflammatory bowel disease.
Seminars in immunology 2006;18(4):244-53.
2006: Marie-Julie Dubois; Sébastien Bergeron; Hyo-Jeong Kim; Luce Dombrowski; Mylène Perreault; Bénédicte Fournès; Robert Faure; Martin Olivier; Nicole Beauchemin; Gerald I Shulman; Katherine A Siminovitch; Jason K Kim; André Marette
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Nature medicine 2006;12(5):549-56.
2006: William G Newman; Xiangjun Gu; Richard F Wintle; Xiangdong Liu; Mark Van Oene; Christopher I Amos; Katherine A Siminovitch
DLG5 variants contribute to Crohn disease risk in a Canadian population.
Human mutation 2006;27(4):353-8.
2006: Jean-Paul Achkar; Themistocles Dassopoulos; Mark S Silverberg; Jeffrey A Tuvlin; Richard H Duerr; Steven R Brant; Katherine A Siminovitch; Deepa Reddy; Lisa Datta; Theodore M Bayless; Leilei Zhang; M. Michael Barmada; John D Rioux; A Hillary Steinhart; Robin S McLeod; Anne M Griffiths; Zane Cohen; Huiying Yang; Gillian P Bromfield; Phil Schumm; Stephen B Hanauer; Judy H Cho; Dan L Nicolae
Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus.
The American journal of gastroenterology 2006;101(3):572-80.
2006: Katherine A Siminovitch
Henry Friesen Award. Inflammatory bowel disease in the era of genomic medicine.
Clinical and investigative medicine. Médecine clinique et experimentale 2006;29(1):40-8.
2006: Miles D Thompson; Jun Takasaki; Valérie Capra; G Enrico Rovati; Katherine A Siminovitch; W McIntyre Burnham; Thomas J Hudson; Yohan Bossé; David E C Cole
G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.
Molecular diagnosis & therapy 2006;10(6):353-66.
2005: Yingchun Wang; Eric Vachon; Jinyi Zhang; Vera Cherepanov; Joshua Kruger; Jun Li; Kan Saito; Patrick Shannon; Nunzio Bottini; Huong Huynh; Heyu Ni; Hong Yang; Colin McKerlie; Sue Quaggin; Zhizhuang Joe Zhao; Philip A Marsden; Tomas Mustelin; Katherine A Siminovitch; Gregory P Downey
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.
The Journal of experimental medicine 2005;202(11):1587-97.
2005: Mark Van Oene; Richard F Wintle; Xiangdong Liu; Mehrdad Yazdanpanah; Xiangjun Gu; Bill Newman; Albert Kwan; Benjamin Johnson; Julie Owen; Wenda Greer; Dianne Mosher; Walter P Maksymowych; Ed Keystone; Laurence A Rubin; Christopher I Amos; Katherine A Siminovitch
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Arthritis and rheumatism 2005;52(7):1993-8.
2005: Bill Newman; Katherine A Siminovitch
Recent advances in the genetics of inflammatory bowel disease.
Current opinion in gastroenterology 2005;21(4):401-7.
2005: Geneviève Forget; Claudine Matte; Katherine A Siminovitch; Serge Rivest; Philippe Pouliot; Martin Olivier
Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1.
European journal of immunology 2005;35(6):1906-17.
2005: Bill Newman; David Cescon; Anna Woo; Harry Rakowski; Maria J Erikkson; Michael Sole; E Douglas Wigle; Katherine A Siminovitch
W4R variant in CSRP3 encoding muscle LIM protein in a patient with hypertrophic cardiomyopathy.
Molecular genetics and metabolism 2005;84(4):374-5.
2005: Bill Newman; Richard F Wintle; Mark Van Oene; Mehrdad Yazdanpanah; Julie Owen; Ben Johnson; Xiangjun Gu; Christopher I Amos; Edward Keystone; Laurence A Rubin; Katherine A Siminovitch
SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population.
Arthritis and rheumatism 2005;52(2):425-9.
2005: Bill Newman; Xiangjun Gu; Richard F Wintle; David Cescon; Mehrdad Yazdanpanah; Xiangdong Liu; Vanya Peltekova; Mark Van Oene; Christopher I Amos; Katherine A Siminovitch
A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.
Gastroenterology 2005;128(2):260-9.
2005: Yan Leng; Jinyi Zhang; Karen Badour; Enrico Arpaia; Spencer Alexander Freeman; Pam Cheung; Michael Siu; Katherine A Siminovitch
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1098-103.
2005: Miles D Thompson; Raffick A R Bowen; Betty Y L Wong; Joan Antal; Zhanqin Liu; Helen Yu; Katherine A Siminovitch; Nancy Kreiger; Thomas E Rohan; David E C Cole
Whole genome amplification of buccal cell DNA: genotyping concordance before and after multiple displacement amplification.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(2):157-62.
2004: Katherine A Siminovitch
PTPN22 and autoimmune disease.
Nature genetics 2004;36(12):1248-9.
2004: Karen Badour; Jinyi Zhang; Katherine A Siminovitch
Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell activation.
Seminars in immunology 2004;16(6):395-407.
2004: Sonja Majstoravich; Jinyi Zhang; Susan Nicholson-Dykstra; Stefan Linder; Wilhelm Friedrich; Katherine A Siminovitch; Henry N Higgs
Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology.
Blood 2004;104(5):1396-403.
2004: Vanessa Morales-Tirado; Sara Johannson; Elaine Hanson; Alan Howell; Jinyi Zhang; Katherine A Siminovitch; Deborah J Fowell
Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):726-30.
2004: Siang-Yo Lin; Shital Raval; Zhiyong Zhang; Michele Deverill; Katherine A Siminovitch; Donald R Branch; Beatrice Haimovich
The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin.
The Journal of biological chemistry 2004;279(24):25755-64.
2004: Vanya Peltekova; Richard F Wintle; Laurence A Rubin; Christopher I Amos; Qiqing Huang; Xiangjun Gu; Bill Newman; Mark Van Oene; David Cescon; Gordon Greenberg; Anne M Griffiths; Peter St George-Hyslop; Katherine A Siminovitch
Functional variants of OCTN cation transporter genes are associated with Crohn disease.
Nature genetics 2004;36(5):471-5.
2004: Bill Newman; David Cescon; Adam Domenchini; Katherine A Siminovitch
CD2BP1 and CARD15 mutations are not associated with pyoderma gangrenosum in patients with inflammatory bowel disease.
The Journal of investigative dermatology 2004;122(4):1054-6.
2004: Bill Newman; Mark S Silverberg; Xiangjun Gu; Qing Zhang; Ana Lazaro; A Hillary Steinhart; Gordon R Greenberg; Anne M Griffiths; Robin S McLeod; Zane Cohen; Marcelo Fernández-Viña; Christopher I Amos; Katherine A Siminovitch
CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease.
The American journal of gastroenterology 2004;99(2):306-15.
2004: Karen Badour; Jinyi Zhang; Fabio Shi; Yan Leng; Michael Collins; Katherine A Siminovitch
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
The Journal of experimental medicine 2004;199(1):99-112.
2003: Katherine A Siminovitch
Prenatal diagnosis and genetic analysis of Wiskott-Aldrich syndrome.
Prenatal diagnosis 2003;23(12):1014-6.
2003: H Nicholas Marsh; Catherine I Dubreuil; Celia Quevedo; Anna Lee; Marta Majdan; Gregory S Walsh; Sharon Hausdorff; Farid Arab Said; Olga Zoueva; Maya Kozlowski; Katherine A Siminovitch; Benjamin G Neel; Freda D Miller; David R Kaplan
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.
The Journal of cell biology 2003;163(5):999-1010.
2003: Bill Newman; Katherine A Siminovitch
Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.
Clinical and investigative medicine. Médecine clinique et experimentale 2003;26(6):303-14.
2003: Yiling Lu; Qinghua Yu; Jue Hui Liu; Jinyi Zhang; Hongwei Wang; Dimpy Koul; John S McMurray; Xianjun Fang; W K Alfred Yung; Katherine A Siminovitch; Gordon B Mills
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
The Journal of biological chemistry 2003;278(41):40057-66.
2003: Miles D Thompson; Karin Storm van's Gravesande; Helen Galczenski; W McIntyre Burnham; Katherine A Siminovitch; Noe Zamel; Arthur Slutsky; Jeffrey M Drazen; Susan R George; Jilly F Evans; Brian F O'Dowd
A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.
Pharmacogenetics 2003;13(10):641-9.
2003: Mairi MacGillivray; Maria Teresa Herrera-Abreu; Chung-Wai Chow; Christina Shek; Qin Wang; Eric Vachon; Gen-Sheng Feng; Katherine A Siminovitch; Christopher A McCulloch; Gregory P Downey
The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts.
The Journal of biological chemistry 2003;278(29):27190-8.
2003: Andrew R Crow; Seng Song; John Freedman; Cheryl D Helgason; R Keith Humphries; Katherine A Siminovitch; Alan H Lazarus
IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity.
Blood 2003;102(2):558-60.
2003: Karen Badour; Jinyi Zhang; Katherine A Siminovitch
The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation.
Immunological reviews 2003;192():98-112.
2003: Bill Newman; Laurence A Rubin; Katherine A Siminovitch
NOD2/CARD15 gene mutation is not associated with susceptibility to Wegener's granulomatosis.
The Journal of rheumatology 2003;30(2):305-7.
2003: Mark S Silverberg; Lucia Mirea; Shelley B Bull; Janet E Murphy; A Hillary Steinhart; Gordon R Greenberg; Robin S McLeod; Zane Cohen; Judith A Wade; Katherine A Siminovitch
A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease.
Inflammatory bowel diseases 2003;9(1):1-9.
2003: Karen Badour; Jinyi Zhang; Fabio Shi; Mary K H McGavin; Vik Rampersad; Lynne A Hardy; Deborah Field; Katherine A Siminovitch
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.
Immunity 2003;18(1):141-54.
2002: Alison M Crane; Linda Bradbury; David A van Heel; Dermot P B McGovern; Sinead Brophy; Laurence Rubin; Katherine A Siminovitch; B Paul Wordsworth; Andrei Calin; Matthew A Brown
Role of NOD2 variants in spondylarthritis.
Arthritis and rheumatism 2002;46(6):1629-33.
2002: Jinyi Zhang; Fabio Shi; Karen Badour; Yupu Deng; Mary K H McGavin; Katherine A Siminovitch
WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2240-5.
2001: Mary K H McGavin; Karen Badour; L A Hardy; T J Kubiseski; Jinyi Zhang; Katherine A Siminovitch
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
The Journal of experimental medicine 2001;194(12):1777-87.
2001: Mark S Silverberg; Mark J Daly; David N Moskovitz; John D Rioux; Robin S McLeod; Zane Cohen; Gordon R Greenberg; Thomas J Hudson; Katherine A Siminovitch; A Hillary Steinhart
Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies.
Gut 2001;49(6):773-6.
2001: Geneviève Forget; Katherine A Siminovitch; S Brochu; S Rivest; D Radzioch; Martin Olivier
Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis.
European journal of immunology 2001;31(11):3185-96.
2001: Gordon B Mills; Ying Lu; Xiang Fang; Hua Wang; Astrid Eder; Muling Mao; R Swaby; Kwai Wa Cheng; David Stokoe; Katherine A Siminovitch; Robert Jaffe; Joe Gray
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology 2001;28(5 Suppl 16):125-41.
2001: Bruce D Cuevas; Ying Lu; Muling Mao; Jinyi Zhang; Ruth Lapushin; Katherine A Siminovitch; Gordon B Mills
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2001;276(29):27455-61.
2001: Steven Laval; Andrew Timms; S Edwards; Linda Bradbury; Sinead Brophy; Anita Milicic; Laurence Rubin; Katherine A Siminovitch; D E Weeks; Andrei Calin; B Paul Wordsworth; Matthew A Brown
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
American journal of human genetics 2001;68(4):918-26.
2001: Mark S Silverberg; C Clelland; J E Murphy; A Hillary Steinhart; Robin S McLeod; Gordon R Greenberg; Zane Cohen; Katherine A Siminovitch
Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin.
Human genetics 2001;108(3):205-10.
2001: AK Somani; K Yuen; F Xu; Jinyi Zhang; Donald R Branch; Katherine A Siminovitch
The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.
The Journal of biological chemistry 2001;276(3):1938-44.
2000: J Kruger; JR Butler; V Cherapanov; Q Dong; Hedy H Ginzberg; A Govindarajan; Sergio Grinstein; Katherine A Siminovitch; Gregory P Downey
Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5847-59.
2000: Jinyi Zhang; AK Somani; Katherine A Siminovitch
Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling.
Seminars in immunology 2000;12(4):361-78.
2000: John D Rioux; Mark S Silverberg; Mark J Daly; A Hillary Steinhart; Robin S McLeod; Anne M Griffiths; T Green; T S Brettin; V Stone; Shelley B Bull; Alain Bitton; C Noel Williams; Gordon R Greenberg; Zane Cohen; Eric S Lander; Thomas J Hudson; Katherine A Siminovitch
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci.
American journal of human genetics 2000;66(6):1863-70.
2000: L A da Cruz; Sonya Penfold; Jinyi Zhang; AK Somani; Fabio Shi; Mary K H McGavin; X Song; Katherine A Siminovitch
Involvement of the lymphocyte cytoskeleton in antigen-receptor signaling.
Current topics in microbiology and immunology 2000;245(1):135-67.
1999: Ying Lu; Y Z Lin; Ruth Lapushin; Bruce D Cuevas; Xiang Fang; S X Yu; Michael A Davies; H Khan; Tatsuro Furui; Muling Mao; R Zinner; M C Hung; PA Steck; Katherine A Siminovitch; Gordon B Mills
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
1999: Jinyi Zhang; Amro Shehabeldin; L A da Cruz; J Butler; AK Somani; Mary K H McGavin; Ivona Kozieradzki; A O dos Santos; Andras Nagy; Sergio Grinstein; Josef M Penninger; Katherine A Siminovitch
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.
The Journal of experimental medicine 1999;190(9):1329-42.
1999: Bruce D Cuevas; Ying Lu; Steven Watt; Rakesh Kumar; Jinyi Zhang; Katherine A Siminovitch; Gordon B Mills
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
The Journal of biological chemistry 1999;274(39):27583-9.
1999: Jinyi Zhang; AK Somani; D Yuen; Y Yang; P E Love; Katherine A Siminovitch
Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3012-21.
1999: AK Somani; N Esmail; Katherine A Siminovitch
Gene therapy and dermatology: more than just skin deep.
Journal of cutaneous medicine and surgery 1999;3(5):249-59.
1999: Jinyi Zhang; AK Somani; Steven Watt; Gordon B Mills; Katherine A Siminovitch
The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6359-67.
1999: Q Dong; Katherine A Siminovitch; Léa Fialkow; T Fukushima; Gregory P Downey
Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3220-30.
1999: Katherine A Siminovitch; Anne-Marie Lamhonwah; AK Somani; Robert Cardiff; Gordon B Mills
Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation.
Current topics in microbiology and immunology 1999;246():291-7; discussion 298.
1998: John D Rioux; Mark J Daly; T Green; V Stone; Eric S Lander; Thomas J Hudson; A Hillary Steinhart; S Bull; Zane Cohen; Gordon Greenberg; A Griffiths; R McLeod; Mark S Silverberg; C Noel Williams; Katherine A Siminovitch
Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16.
Gastroenterology 1998;115(5):1062-5.
1998: Katherine A Siminovitch; B G Neel
Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases.
Seminars in immunology 1998;10(4):329-47.
1998: Matthew A Brown; M Rudwaleit; KD Pile; LG Kennedy; JL Shatford; C I Amos; Katherine A Siminovitch; Laurence Rubin; Andrei Calin; B Paul Wordsworth
The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
British journal of rheumatology 1998;37(4):454-8.
1998: Katherine A Siminovitch
Role of infection in autoimmune disease.
Seminars in immunology 1998;10(1):1-3.
1997: Christopher I Amos; Y Wan; Katherine A Siminovitch; Laurence A Rubin
Estimating the strength of genetic effects: a comparison of maximum likelihood and transmission disequilibrium methods in the study of ankylosing spondylitis.
Human immunology 1997;57(1):44-50.
1997: AK Somani; J S Bignon; Gordon B Mills; Katherine A Siminovitch; Donald R Branch
Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.
The Journal of biological chemistry 1997;272(34):21113-9.
1997: G Pani; Katherine A Siminovitch; Christopher J Paige
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice.
The Journal of experimental medicine 1997;186(4):581-8.
1997: Catharine I Whiteside; S Dessureault; JB Dickstein; LA Tibbles; Shona Torrance; Erin L Boynton; M Seeman; Katherine A Siminovitch; D Stewart
Women in biomedical research--addressing the challenges.
Clinical and investigative medicine. Médecine clinique et experimentale 1997;20(4):268-72.
1997: Katherine A Siminovitch
Report from the University of Toronto Department of Medicine Ad Hoc Committee on career development of clinician scientists.
Clinical and investigative medicine. Médecine clinique et experimentale 1997;20(4):265-7.
1997: G Pani; Katherine A Siminovitch
Protein tyrosine phosphatase roles in the regulation of lymphocyte signaling.
Clinical immunology and immunopathology 1997;84(1):1-16.
1996: W L Greer; A Shehabeldin; J Schulman; A Junker; Katherine A Siminovitch
Identification of WASP mutations, mutation hotspots and genotype-phenotype disparities in 24 patients with the Wiskott-Aldrich syndrome.
Human genetics 1996;98(6):685-90.
1996: G Pani; Klaus-Dieter Fischer; I Mlinaric-Rascan; Katherine A Siminovitch
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
The Journal of experimental medicine 1996;184(3):839-52.
1996: Robert F Paulson; S Vesely; Katherine A Siminovitch; alan bernstein
Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.
Nature genetics 1996;13(3):309-15.
1996: M Kon-Kozlowski; G Pani; T Pawson; Katherine A Siminovitch
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
The Journal of biological chemistry 1996;271(7):3856-62.
1995: Y Wu; G Pani; Katherine A Siminovitch; Nobumichi Hozumi
Antigen receptor-triggered apoptosis in immature B cell lines is associated with the binding of a 44-kDa phosphoprotein to the PTP1C tyrosine phosphatase.
European journal of immunology 1995;25(8):2279-84.
1995: R Kolluri; A Shehabeldin; M Peacocke; Anne-Marie Lamhonwah; K Teichert-Kuliszewska; S M Weissman; Katherine A Siminovitch
Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus.
Human molecular genetics 1995;4(7):1119-26.
1995: G Pani; M Kozlowski; John C Cambier; Gordon B Mills; Katherine A Siminovitch
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.
The Journal of experimental medicine 1995;181(6):2077-84.
1995: D D'Ambrosio; K L Hippen; S A Minskoff; I Mellman; G Pani; Katherine A Siminovitch; John C Cambier
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
Science (New York, N.Y.) 1995;268(5208):293-7.
1995: Katherine A Siminovitch; W L Greer; A Novogrodsky; B Axelsson; AK Somani; M Peacocke
A diagnostic assay for the Wiskott-Aldrich syndrome and its variant forms.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1995;43(2):159-69.
1995: D F Huang; Katherine A Siminovitch; X Y Liu; T Olee; N J Olsen; C Berry; Dennis A Carson; Pojen P Chen
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.
The Journal of clinical investigation 1995;95(4):1766-72.
1994: M D Daley; Neil L Berinstein; Katherine A Siminovitch
Immunoglobulin heavy chain variable gene utilization in human large cell and Burkitt's lymphoma cell lines.
Clinical and investigative medicine. Médecine clinique et experimentale 1994;17(6):522-30.
1994: J S Bignon; Katherine A Siminovitch
Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.
Clinical immunology and immunopathology 1994;73(2):168-79.
1994: I Mlinaric-Rascan; Sylvia Asa; Katherine A Siminovitch
Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice.
The American journal of pathology 1994;145(4):902-12.
1993: M Kozlowski; I Mlinaric-Rascan; Gen-Sheng Feng; R Shen; Tony Pawson; Katherine A Siminovitch
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
The Journal of experimental medicine 1993;178(6):2157-63.
1993: K Yuh; Katherine A Siminovitch; A Ochi
T cell anergy is programmed early after exposure to bacterial superantigen in vivo.
International immunology 1993;5(11):1375-82.
1993: S M Cremin; W L Greer; R Bodok-Nutzati; M Schwartz; M Peacocke; Katherine A Siminovitch
Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region.
Human genetics 1993;92(3):250-3.
1993: A Ochi; K Migita; J Xu; Katherine A Siminovitch
In vivo tumor immunotherapy by a bacterial superantigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3180-6.
1993: M D Daley; V Misener; T Olee; Pojen P Chen; Katherine A Siminovitch
Genetic analysis of the variable region genes encoding a monospecific human natural anti-DNA antibody.
Clinical and experimental immunology 1993;93(1):11-8.
1993: Hing Wo Tsui; Katherine A Siminovitch; L de Souza; Florence W L Tsui
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.
Nature genetics 1993;4(2):124-9.
1993: Florence W L Tsui; Hing Wo Tsui; Samuel C Mok; I Mlinaric; N G Copeland; D J Gilbert; N A Jenkins; Katherine A Siminovitch
Molecular characterization and mapping of murine genes encoding three members of the stefin family of cysteine proteinase inhibitors.
Genomics 1993;15(3):507-14.
1993: H U Simon; Elizabeth Ann Higgins; M Demetriou; A Datti; Katherine A Siminovitch; James W Dennis
Defective expression of CD23 and autocrine growth-stimulation in Epstein-Barr virus (EBV)-transformed B cells from patients with Wiskott-Aldrich syndrome (WAS).
Clinical and experimental immunology 1993;91(1):43-9.
1993: Katherine A Siminovitch; W L Greer; B Axelsson; L A Rubin; A Novogrodsky; M Peacocke
Selective impairment of CD43-mediated T cell activation in the Wiskott-Aldrich syndrome.
Immunodeficiency 1993;4(1-4):99-108.
1992: M D Daley; H Q Peng; V Misener; X Y Liu; Pojen P Chen; Katherine A Siminovitch
Molecular analysis of human immunoglobulin V lambda germline genes: subgroups V lambda III and V lambda IV.
Molecular immunology 1992;29(12):1515-8.
1992: A Datti; Antonio Orlacchio; Katherine A Siminovitch; James W Dennis
A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).
Analytical biochemistry 1992;206(2):262-6.
1992: H U Simon; Gordon B Mills; S Hashimoto; Katherine A Siminovitch
Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.
The Journal of clinical investigation 1992;90(4):1396-405.
1992: M D Daley; T Olee; H Q Peng; R W Soto-Gil; Pojen P Chen; Katherine A Siminovitch
Molecular characterization of the human immunoglobulin V lambda I germline gene repertoire.
Molecular immunology 1992;29(9):1031-42.
1992: W L Greer; M Peacocke; Katherine A Siminovitch
The Wiskott-Aldrich syndrome: refinement of the localization on Xp and identification of another closely linked marker locus, OATL1.
Human genetics 1992;88(4):453-6.
1991: C Kim; Katherine A Siminovitch; A Ochi
Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment.
The Journal of experimental medicine 1991;174(6):1431-7.
1991: T Olee; P M Yang; Katherine A Siminovitch; N J Olsen; J Hillson; J Wu; F Kozin; Dennis A Carson; Pojen P Chen
Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases.
The Journal of clinical investigation 1991;88(1):193-203.
1991: Elizabeth Ann Higgins; Katherine A Siminovitch; D L Zhuang; I Brockhausen; James W Dennis
Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome.
The Journal of biological chemistry 1991;266(10):6280-90.
1991: Florence W L Tsui; Katherine A Siminovitch
Anti-Jo-1 autoantibodies and the immunopathogenesis of autoimmune myositis.
International reviews of immunology 1991;7(3):225-35.
1990: P M Yang; N J Olsen; Katherine A Siminovitch; T Olee; F Kozin; Dennis A Carson; Pojen P Chen
Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7907-11.
1990: A C Schuh; D Robert Sutherland; W Horsfall; G B Mills; I Dube; M A Baker; Katherine A Siminovitch; D Bailey; Armand Keating
Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells.
Leukemia 1990;4(9):631-6.
1990: W L Greer; AK Somani; P C Kwong; M Peacocke; L A Rubin; Katherine A Siminovitch
Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome.
Genomics 1990;6(3):568-71.
1990: Katherine A Siminovitch; Pojen P Chen
The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire.
International reviews of immunology 1990;5(3-4):265-77.
1990: Pojen P Chen; N J Olsen; P M Yang; R W Soto-Gil; T Olee; Katherine A Siminovitch; Dennis A Carson
From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.
International reviews of immunology 1990;5(3-4):239-51.
1990: Katherine A Siminovitch; V Misener; P C Kwong; P M Yang; Carl A Laskin; E Cairns; D Bell; L A Rubin; Pojen P Chen
A human anti-cardiolipin autoantibody is encoded by developementally restricted heavy and light chain variable region genes.
Autoimmunity 1990;8(2):97-105.
1989: Katherine A Siminovitch; V Misener; P C Kwong; Q L Song; Pojen P Chen
A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.
The Journal of clinical investigation 1989;84(5):1675-8.
1989: W L Greer; M M Mahtani; P C Kwong; L A Rubin; M Peacocke; H F Willard; Katherine A Siminovitch
Linkage studies of the Wiskott-Aldrich syndrome: polymorphisms at TIMP and the X chromosome centromere are informative markers for genetic prediction.
Human genetics 1989;83(3):227-30.
1989: Dale A Ramsden; J Chen; Frederick Miller; V Misener; R M Bernstein; Katherine A Siminovitch; Florence W L Tsui
Epitope mapping of the cloned human autoantigen, histidyl-tRNA synthetase. Analysis of the myositis-associated anti-Jo-1 autoimmune response.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2267-72.
1989: W L Greer; E Higgins; D Robert Sutherland; A Novogrodsky; Inka Brockhausen; M Peacocke; L A Rubin; M Baker; J W Dennis; Katherine A Siminovitch
Altered expression of leucocyte sialoglycoprotein in Wiskott-Aldrich syndrome is associated with a specific defect in O-glycosylation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1989;67(9):503-9.
1989: Pojen P Chen; Katherine A Siminovitch; N J Olsen; R A Erger; Dennis A Carson
A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.
The Journal of clinical investigation 1989;84(2):706-10.
1989: E Cairns; P C Kwong; V Misener; P Ip; D A Bell; Katherine A Siminovitch
Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):685-91.
1989: W L Greer; P C Kwong; M Peacocke; P Ip; L A Rubin; Katherine A Siminovitch
X-chromosome inactivation in the Wiskott-Aldrich syndrome: a marker for detection of the carrier state and identification of cell lineages expressing the gene defect.
Genomics 1989;4(1):60-7.