Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Anne Simmonds

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Anatomy

Erythrocytes

Chemicals & Drugs

Procedures

High Pressure Liquid Chromatography

Concepts & Ideas

Pedigree

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
57
Fairbanks, Lynette
35
Duley, John
21
Smolenski, Ryszard
14
Cameron, Stewart
13
Marinaki, Anthony
12
McBride, MB
9
Micheli, Vanna
9
Carrey, Elizabeth
7
Laurence, Arian
6
Levinsky, Roland
6
Sahota, Amrik
6
Tischfield, Jay
5
Ogg, CS
5
Marlewski, Maciej
5
Goldsmith, David

Sign-in to see all Coauthors

Publications

TOP 3
Li Mei-Ling; Kwan Tzu-Yu; Simmonds H Anne; Stollar Victor
Synthesis of genomic and subgenomic RNA in mosquito cells infected with two Sindbis virus nsP4 mutants: influence of intracellular nucleoside triphosphate concentrations.
Slominska E M; Orlewska C; Yuen A; Osman L; Romaszko P; Sokolowska E; Foks H; Simmonds H A; Yacoub M H; Smolenski R T
Metabolism of 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate and its nucleoside precursor in the erythrocytes.
Laurence A; Edbury S M; Marinaki A M; Smolenski R T; Goldsmith D J A; Simmonds H A; Carrey E A
4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Anne Simmonds (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2008: Li Mei-Ling; Kwan Tzu-Yu; Simmonds H Anne; Stollar Victor
Synthesis of genomic and subgenomic RNA in mosquito cells infected with two Sindbis virus nsP4 mutants: influence of intracellular nucleoside triphosphate concentrations.
Journal of virology 2008;82(14):6880-8.
2008: Slominska E M; Orlewska C; Yuen A; Osman L; Romaszko P; Sokolowska E; Foks H; Simmonds H A; Yacoub M H; Smolenski R T
Metabolism of 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate and its nucleoside precursor in the erythrocytes.
Nucleosides, nucleotides & nucleic acids 2008;27(6):830-4.
2007: Laurence A; Edbury S M; Marinaki A M; Smolenski R T; Goldsmith D J A; Simmonds H A; Carrey E A
4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism.
Clinical and experimental medicine 2007;7(4):135-41.
2006: Slominska Ewa M; Carrey Elizabeth A; Foks Henryk; Orlewska Czeslawa; Wieczerzak Ewa; Sowinski Pawel; Yacoub Magdi H; Marinaki Anthony M; Simmonds H Anne; Smolenski Ryszard T
A novel nucleotide found in human erythrocytes, 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate.
The Journal of biological chemistry 2006;281(43):32057-64.
2006: Davies Phillip M; Fairbanks Lynette D; Safranow Krzysztof; Bending Michael R; Simmonds H Anne
An unusual patient with kidney stones composed of 1-methyluric acid.
Urological research 2006;34(1):58-60.
2006: Staub M; Stenger A; Sumeg R; Spasokoukotskaja T; Fairbanks L D; Simmonds H A; Keszler G
The neuroleptic chlorpromazine inhibits the cationic and stimulates the anionic phospholipid precursor synthesis in human lymphocytes.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1133-9.
2006: Simmonds H A; Cameron J S; Goldsmith D J; Fairbanks L D; Raman G Venkat
Familial juvenile hyperuricaemic nephropathy is not such a rare genetic metabolic purine disease in Britain.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1071-5.
2006: Carrey E A; Synesiou E; Simmonds H A; Fairbanks L D
The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1051-4.
2005: Vernon Hilary J; Osborne Christine; Tzortzaki Eleni G; Yang Min; Chen Jianmen; Rittling Susan R; Denhardt David T; Buyske Steven; Bledsoe Sharon B; Evan Andrew P; Fairbanks Lynette; Simmonds H Anne; Tischfield Jay A; Sahota Amrik
Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity.
Kidney international 2005;68(3):938-47.
2005: Löffler Monika; Fairbanks Lynette D; Zameitat Elke; Marinaki Anthony M; Simmonds H Anne
Pyrimidine pathways in health and disease.
Trends in molecular medicine 2005;11(9):430-7.
2005: Kassimatis T I; Simmonds H A; Goudas P C; Marinaki A M; Fairbanks L D; Diamandopoulos A A
HPRT deficiency as the cause of ESRD in a 24-year-old patient: a very rare presentation of the disorder.
Journal of nephrology 2005;18(4):447-51.
2005: Cameron J Stewart; Simmonds H Anne
Hereditary hyperuricemia and renal disease.
Seminars in nephrology 2005;25(1):9-18.
2004: Goldsmith D J A; Carrey E A; Edbury S M; Marinaki A M; Simmonds H A
GTP concentrations are elevated in erythrocytes of renal transplant recipients when conventional immunosuppression is replaced by the inosine monophosphate dehydrogenase inhibitor mycophenolic acid mofetil (MMF).
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1407-9.
2004: Laurence A D; Layton M; Duley J A; Simmonds H A
Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1265-7.
2004: Marinaki A M; Champion M; Kurian M A; Simmonds H A; Marie S; Vincent M F; van den Berghe G; Duley J A; Fairbanks L D
Adenylosuccinate lyase deficiency--first British case.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1231-3.
2004: Fairbanks L D; Harris J C; Duley J A; Simmonds H A
Nucleotide degradation products in cerebrospinal fluid (CSF) in inherited and acquired pathologies.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1185-7.
2004: Carrey E A; Smolenski R T; Edbury S M; Laurence A; Marinaki A M; Duley J A; Zhu L M; Goldsmith D J A; Simmonds H A
An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1135-9.
2004: Goldsmith David; Carrey Elizabeth A; Edbury Stephen; Smolenski Ryszard T; Jagodzinski Piotr; Simmonds H Anne
Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients.
Clinical science (London, England : 1979) 2004;107(1):63-8.
2004: Jagodzinski Piotr; Lizakowski Slawomir; Smolenski Ryszard T; Slominska Ewa M; Goldsmith David; Simmonds H Anne; Rutkowski Boleslaw
Mycophenolate mofetil treatment following renal transplantation decreases GTP concentrations in mononuclear leucocytes.
Clinical science (London, England : 1979) 2004;107(1):69-74.
2004: Cassidy Michael J D; McCulloch Tom; Fairbanks Lynette D; Simmonds H Anne
Diagnosis of adenine phosphoribosyltransferase deficiency as the underlying cause of renal failure in a renal transplant recipient.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(3):736-8.
2004: Fairbanks L D; Marinaki A M; Simmonds H A; Cameron J S
Familial juvenile hyperuricaemic nephropathy.
QJM : monthly journal of the Association of Physicians 2004;97(2):106-7.
2003: Carrey Elizabeth A; Smolenski Ryszard T; Edbury Stephen M; Laurence Arian; Marinaki Anthony M; Duley John A; Zhu Limin; Goldsmith David J A; Simmonds H Anne
Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure.
Clinica chimica acta; international journal of clinical chemistry 2003;335(1-2):117-29.
2003: Bingham Coralie; Ellard Sian; van't Hoff William G; Simmonds H Anne; Marinaki Anthony M; Badman Michael K; Winocour Peter H; Stride Amanda; Lockwood Christopher R; Nicholls Anthony J; Owen Katharine R; Spyer Ghislaine; Pearson Ewan R; Hattersley Andrew T
Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation.
Kidney international 2003;63(5):1645-51.
2002: Sumi Satoshi; Marinaki Anthony M; Arenas Monica; Fairbanks Lynette; Shobowale-Bakre Monsor; Rees David C; Thein Swee Lay; Ansari Azhar; Sanderson Jeremy; De Abreu Ronney A; Simmonds H Anne; Duley John A
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.
Human genetics 2002;111(4-5):360-7.
2002: Fairbanks L D; Cameron J S; Venkat-Raman G; Rigden S P A; Rees L; Van'T Hoff W; Mansell M; Pattison J; Goldsmith D J A; Simmonds H A
Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease.
QJM : monthly journal of the Association of Physicians 2002;95(9):597-607.
2002: Fairbanks Lynette D; Jacomelli Gabriella; Micheli Vanna; Slade Tina; Simmonds H Anne
Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients.
The Biochemical journal 2002;366(Pt 1):265-72.
2002: Slominska Ewa M; Smolenski Ryszard T; Szolkiewicz Marek; Leaver Neil; Rutkowski Boleslaw; Simmonds H Anne; Swierczynski Julian
Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure.
Molecular and cellular biochemistry 2002;231(1-2):83-8.
2002: Augoustides-Savvopoulou Persephone; Papachristou Fotis; Fairbanks Lynette D; Dimitrakopoulos Kostas; Marinaki Anthony M; Simmonds H Anne
Partial hypoxanthine-Guanine phosphoribosyltransferase deficiency as the unsuspected cause of renal disease spanning three generations: a cautionary tale.
Pediatrics 2002;109(1):E17.
2001: Classen C F; Schulz A S; Sigl-Kraetzig M; Hoffmann G F; Simmonds H A; Fairbanks L; Debatin K M; Friedrich W
Successful HLA-identical bone marrow transplantation in a patient with PNP deficiency using busulfan and fludarabine for conditioning.
Bone marrow transplantation 2001;28(1):93-6.
2001: Marinaki A M; Escuredo E; Duley J A; Simmonds H A; Amici A; Naponelli V; Magni G; Seip M; Ben-Bassat I; Harley E H; Thein S L; Rees D C
Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency.
Blood 2001;97(11):3327-32.
2000: Qiu Y; Fairbanks L D; Rückermann K; Hawrlowicz C M; Richards D F; Kirschbaum B; Simmonds H A
Mycophenolic acid-induced GTP depletion also affects ATP and pyrimidine synthesis in mitogen-stimulated primary human T-lymphocytes.
Transplantation 2000;69(5):890-7.
2000: Fairbanks L D; Simmonds H A; Duley J A; Gaspar H B; Flood T; Steward C A
ADA activity and DATP levels in erythrocytes after bone marrow transplantation.
Advances in experimental medicine and biology 2000;486():51-5.
2000: Bax B E; Bain M D; Fairbanks L D; Simmonds H A; Webster A D; Chalmers R A
Carrier erythrocyte entrapped adenosine deaminase therapy in adenosine deaminase deficiency.
Advances in experimental medicine and biology 2000;486():47-50.
2000: Fairbanks L D; Escuredo E; Duley J A; Simmonds H A
Screening for purine and pyrimidine disorders using dried urine spots.
Advances in experimental medicine and biology 2000;486():383-8.
2000: Southgate T; Bain D; Fairbanks L D; Morelli A; Larregina A; Simmonds H A; Castro M; Lowenstein P
Adenoviruses encoding HPRT correct the biochemical abnormalities fully only in HPRT-deficient human cell lines: importance of species differences.
Advances in experimental medicine and biology 2000;486():35-40.
1999: Southgate T D; Bain D; Fairbanks L D; Morelli A E; Larregina A T; Simmonds H A; Castro M G; Löwenstein P R
Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium.
Metabolic brain disease 1999;14(4):205-21.
1999: Smolenska Z; Kaznowska Z; Zarówny D; Simmonds H A; Smolenski R T
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38(10):997-1002.
1999: Fairbanks L D; Carrey E A; Rückemann K; Swaminathan R; Kirschbaum B; Simmonds H A
Simultaneous separation by high-performance liquid chromatography of carbamoyl aspartate, carbamoyl phosphate and dihydroorotic acid.
Journal of chromatography. B, Biomedical sciences and applications 1999;732(2):487-93.
1999: Wang L; Ou X; Sebesta I; Vondrak K; Krijt J; Elleder M; Poupetova H; Ledvinova J; Zeman J; Simmonds H A; Tischfield J A; Sahota A
Combined adenine phosphoribosyltransferase and N-acetylgalactosamine-6-sulfate sulfatase deficiency.
Molecular genetics and metabolism 1999;68(1):78-85.
1999: Fairbanks L D; Rückemann K; Qiu Y; Hawrylowicz C M; Richards D F; Swaminathan R; Kirschbaum B; Simmonds H A
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
The Biochemical journal 1999;342 ( Pt 1)():143-52.
1999: Bofill M; Borthwick N J; Simmonds H A
Novel mechanism for the impairment of cell proliferation in HIV-1 infection.
Immunology today 1999;20(6):258-61.
1999: Simmonds H A; Hoffmann G F; Pérignon J L; Micheli V; van Gennip A H
Diagnosis of molybdenum cofactor deficiency.
Lancet 1999;353(9153):675.
1999: Köhler M; Assmann B; Bräutigam C; Storm W; Marie S; Vincent M F; Van den Berghe G; Simmonds H A; Hoffmann G F
Adenylosuccinase deficiency: possibly underdiagnosed encephalopathy with variable clinical features.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 1999;3(1):3-6.
1998: Rückemann K; Fairbanks L D; Carrey E A; Hawrylowicz C M; Richards D F; Kirschbaum B; Simmonds H A
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.
The Journal of biological chemistry 1998;273(34):21682-91.
1998: McBride M B; Rigden S; Haycock G B; Dalton N; Van't Hoff W; Rees L; Raman G V; Moro F; Ogg C S; Cameron J S; Simmonds H A
Presymptomatic detection of familial juvenile hyperuricaemic nephropathy in children.
Pediatric nephrology (Berlin, Germany) 1998;12(5):357-64.
1998: Hughes E F; Fairbanks L; Simmonds H A; Robinson R O
Molybdenum cofactor deficiency-phenotypic variability in a family with a late-onset variant.
Developmental medicine and child neurology 1998;40(1):57-61.
1998: Marlewski M; Smolenski R T; Laurence A; Simmonds H A; Swierczynski J
Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique.
Advances in experimental medicine and biology 1998;431():785-7.
1998: Ruckemann K; Laurence A; Fairbanks L D; Richards D; Smolenski R T; Hawrylowicz C; Bofill M; Simmonds H A
Biochemical basis for the impaired immune response in chronic renal failure?
Advances in experimental medicine and biology 1998;431():559-63.
1998: Fabianowska-Majewska K; Ruckemann K; Duley J A; Simmonds H A
Effect of Cladribine, fludarabine, and 5-aza-deoxycytidine on S-adenosylmethionine (SAM) and nucleotides pools in stimulated human lymphocytes.
Advances in experimental medicine and biology 1998;431():531-5.
1998: Stone T W; Roberts L A; Morris B J; Jones P A; Ogilvy H A; Behan W M; Duley J A; Simmonds H A; Vincent M F; van den Berghe G
Succinylpurines induce neuronal damage in the rat brain.
Advances in experimental medicine and biology 1998;431():185-9.
1998: Laurence A; Duley J A; Simmonds H A; Layton M; Rose S J; Kelly S J
Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF).
Advances in experimental medicine and biology 1998;431():155-9.
1998: Stone T W; Duley J A; Simmonds H A; Vincent M F; van den Berghe G
Succinylpurines do not modify glutamate or adenosine effects in the CNS.
Advances in experimental medicine and biology 1998;431():119-23.
1998: Reiter S; Engelleiter R; Proske H; Müller A; van der Woude F J; Duley J A; Simmonds H A
Severe debilitating polyarticular gout and terminal renal failure in an allopurinol 'non-responder'.
Advances in experimental medicine and biology 1998;431():51-5.
1998: Davies P M; Simmonds H A; Singer B; Mant T G; Allen E M; Vassos A B; Hounslow N J
Plasma uridine as well as uric acid is elevated following fructose loading.
Advances in experimental medicine and biology 1998;431():31-5.
1998: Grahame R; Simmonds H A; McBride M B; Marsh F P
How should we treat tophaceous gout in patients with allopurinol hypersensitivity?
Advances in experimental medicine and biology 1998;431():19-23.
1998: McBride M B; Simmonds H A; Ogg C S; Cameron J S; Rigden S; Rees L; Van 't Hoff W; Moro F; Raman G V
Efficacy of allopurinol in ameliorating the progressive renal disease in familial juvenile hyperuricaemic nephropathy (FJHN). A six-year update.
Advances in experimental medicine and biology 1998;431():7-11.
1997: McBride M B; Simmonds H A; Moro F
Familial renal disease or familial juvenile hyperuricaemic nephropathy?
Journal of inherited metabolic disease 1997;20(3):351-3.
1997: Davies P M; Fairbanks L D; Duley J A; Simmonds H A
Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism.
Journal of inherited metabolic disease 1997;20(3):328-30.
1997: Simmonds H A; Duley J A; Fairbanks L D; McBride M B
When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications.
Journal of inherited metabolic disease 1997;20(2):214-26.
1996: Engle S J; Womer D E; Davies P M; Boivin G; Sahota A; Simmonds H A; Stambrook P J; Tischfield J A
HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome.
Human molecular genetics 1996;5(10):1607-10.
1996: Engle S J; Stockelman M G; Chen J; Boivin G; Yum M N; Davies P M; Ying M Y; Sahota A; Simmonds H A; Stambrook P J; Tischfield J A
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5307-12.
1995: Bofill M; Fairbanks L D; Ruckemann K; Lipman M; Simmonds H A
T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection.
The Journal of biological chemistry 1995;270(50):29690-7.
1995: Fairbanks L D; Bofill M; Ruckemann K; Simmonds H A
Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.
The Journal of biological chemistry 1995;270(50):29682-9.
1994: Simmonds H A; McBride M B; Hatfield P J; Graham R; McCaskey J; Jackson M
Polynesian women are also at risk for hyperuricaemia and gout because of a genetic defect in renal urate handling.
British journal of rheumatology 1994;33(10):932-7.
1994: Shovlin C L; Simmonds H A; Fairbanks L D; Deacock S J; Hughes J M; Lechler R I; Webster A D; Sun X M; Webb J C; Soutar A K
Adult onset immunodeficiency caused by inherited adenosine deaminase deficiency.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2331-9.
1994: Pescaglini M; Micheli V; Simmonds H A; Rocchigiani M; Pompucci G
Nicotinic acid phosphoribosyltransferase activity in human erythrocytes: studies using a new HPLC method.
Clinica chimica acta; international journal of clinical chemistry 1994;229(1-2):15-25.
1994: Fabianowska-Majewska K; Duley J A; Simmonds H A
Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver.
Biochemical pharmacology 1994;48(5):897-903.
1994: Bye S; Mallmann R; Duley J; Simmonds H A; Chen J; Tischfield J A; Sahota A
Identification of a 7-basepair deletion in the adenine phosphoribosyltransferase gene as a cause of 2,8-dihydroxyadenine urolithiasis.
The Clinical investigator 1994;72(7):550-3.
1994: Simmonds H A
When and how does one search for inborn errors of purine and pyrimidine metabolism?
Pharmacy world & science : PWS 1994;16(2):139-48.
1994: Sebesta I; Fairbanks L D; Davies P M; Simmonds H A; Leonard J V
The allopurinol loading test for identification of carriers for ornithine carbamoyl transferase deficiency: studies in a healthy control population and females at risk.
Clinica chimica acta; international journal of clinical chemistry 1994;224(1):45-54.
1994: Sebesta I; Krijt J; Fairbanks L D; Simmonds H A
The allopurinol loading test in detecting obligate heterozygotes for OCT deficiency.
Journal of inherited metabolic disease 1994;17(1):133-4.
1994: Fairbanks L D; Shovlin C L; Webster A D; Hughes J M; Simmonds H A
Adenosine deaminase deficiency with altered biochemical parameters in two sisters with late-onset immunodeficiency.
Journal of inherited metabolic disease 1994;17(1):135-7.
1994: Sebesta I; Krijt J; Pavelka K; Maly J; Simmonds H A; McBride M B
Familial juvenile hyperuricaemic nephropathy in adolescents.
Advances in experimental medicine and biology 1994;370():73-6.
1994: Sahota A; Bye S; Chen J; Khattar N H; Turker M S; Moro F; Simmonds H A; Emmerson B T; Gordon R B; Tischfield J A
Molecular characterization of a novel mutation in APRT heterozygotes.
Advances in experimental medicine and biology 1994;370():675-8.
1994: Kmiec Z; Marlewski M; Smolenski R T; Simmonds H A
Effect of galactosamine on adenine and uracil nucleotide levels in isolated hepatocytes of young and old rats.
Advances in experimental medicine and biology 1994;370():523-6.
1994: Fairbanks L D; Simmonds H A; Webster A D; Shovlin C L; Hughes J M
Adenosine deaminase (ADA) deficiency as the unexpected cause of CD4+ T-lymphocytopenia in two HIV-negative adult female siblings.
Advances in experimental medicine and biology 1994;370():471-4.
1994: Fabianowska-Majewska K; Smolenski R T; Marlewski M; Duley J A; Simmonds H A
SAH-hydrolase activity in haemolysate and intact erythrocytes; the effect of adenosine analogues.
Advances in experimental medicine and biology 1994;370():439-41.
1994: McBride M B; Simmonds H A; Hatfield P J; Graham R; McCaskey J; Jackson M
Renal urate hypoexcretion in Polynesian women is not as severe as in United Kingdom (UK) women with familial juvenile hyperuricaemic nephropathy (FJHN).
Advances in experimental medicine and biology 1994;370():35-8.
1994: Smolenski R T; Simmonds H A; Chambers D J
Purine and pyrimidine catabolite production in the postischemic rat heart--effect of adenosine supply during reperfusion.
Advances in experimental medicine and biology 1994;370():319-22.
1994: Marlewski M; Smolenski R T; Swierczynski J; Rutkowski B; Duley J A; Simmonds H A; Zydowo M M
Accelerated purine base salvage--a possible cause of elevated nucleotide pool in the erythrocytes of patients with uraemia.
Advances in experimental medicine and biology 1994;370():19-22.
1994: Simmonds H A
Diagnosis and treatment of inborn errors of purine and pyrimidine metabolism: an overview.
Advances in experimental medicine and biology 1994;370():1-6.
1993: Smolenski R T; Simmonds H A; Garlick P B; Venn G E; Chambers D J
Depressed adenosine and total purine catabolite production in the postischemic rat heart.
Cardioscience 1993;4(4):235-40.
1993: Micheli V; Simmonds H A; Bari M; Pompucci G
HPLC determination of oxidized and reduced pyridine coenzymes in human erythrocytes.
Clinica chimica acta; international journal of clinical chemistry 1993;220(1):1-17.
1993: Shovlin C L; Hughes J M; Simmonds H A; Fairbanks L; Deacock S; Lechler R; Roberts I; Webster A D
Adult presentation of adenosine deaminase deficiency.
Lancet 1993;341(8858):1471.
1993: Cameron J S; Moro F; Simmonds H A
Gout, uric acid and purine metabolism in paediatric nephrology.
Pediatric nephrology (Berlin, Germany) 1993;7(1):105-18.
1993: Henderson M J; Ward K; Simmonds H A; Duley J A; Davies P M
Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay.
Journal of inherited metabolic disease 1993;16(3):574-6.
1992: Rocchigiani M; Micheli V; Duley J A; Simmonds H A
Determination of nicotinamide phosphoribosyltransferase activity in human erythrocytes: high-performance liquid chromatography-linked method.
Analytical biochemistry 1992;205(2):334-6.
1992: Smolenski R T; Fabianowska-Majewska K; Montero C; Duley J A; Fairbanks L D; Marlewski M; Simmonds H A
A novel route of ATP synthesis.
Biochemical pharmacology 1992;43(10):2053-7.
1992: Simmonds H; Van Acker K J; Sahota A S
2,8-Dihydroxyadenine urolithiasis.
Lancet 1992;339(8804):1295-6.
1991: Smolenski R T; Montero C; Duley J A; Simmonds H A
Effects of adenosine analogues on ATP concentrations in human erythrocytes. Further evidence for a route independent of adenosine kinase.
Biochemical pharmacology 1991;42(9):1767-73.
1991: Smolenski R T; Montero C; Rodgers A V; Simmonds H A
A high performance liquid chromatographic assay for AMP-deaminase activity in the erythrocytes of healthy subjects and patients with inherited purine disorders.
Biomedical chromatography : BMC 1991;5(4):171-4.
1991: Moro F; Ogg C S; Simmonds H A; Cameron J S; Chantler C; McBride M B; Duley J A; Davies P M
Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal disease.
Clinical nephrology 1991;35(6):263-9.
1991: Simmonds H A; Reiter S; Davies P M; Cameron J S
Orotidine accumulation in human erythrocytes during allopurinol therapy: association with high urinary oxypurinol-7-riboside concentrations in renal failure and in the Lesch-Nyhan syndrome.
Clinical science (London, England : 1979) 1991;80(3):191-7.
1991: Montero C; Smolenski R T; Duley J A; Simmonds H A
An alternative pathway of adenylate and ATP synthesis.
Advances in experimental medicine and biology 1991;309A():285-8.
1991: Moro F; Simmonds H A; Cameron J S; Ogg C S; Williams G D; McBride M B; Davis P M
Does allopurinol affect the progression of familial juvenile gouty nephropathy?
Advances in experimental medicine and biology 1991;309A():199-202.
1991: McBride M B; Raman V; Ogg C S; Chantler C; Cameron J S; Duley J A; Simmonds H A
Renal urate hypoexcretion preceding renal disease in a new kindred with familial juvenile gouty nephropathy (FJGN).
Advances in experimental medicine and biology 1991;309A():191-4.
1991: Davies P M; McBride M B; Simmonds H A
An improved screening method for inherited disorders of purine and pyrimidine metabolism by HPLC.
Advances in experimental medicine and biology 1991;309B():7-10.
1991: Fairbanks L D; Duley J A; Shores A J; Simmonds H A
HPLC assay of uridine monophosphate synthase (UMPS) in chorionic villus samples (CVS) and erythrocytes (RBC).
Advances in experimental medicine and biology 1991;309B():35-8.
1991: Rocchigiani M; Sestini S; Micheli V; Bari M; Simmonds H A
NAD synthesis in human erythrocytes: determination of the activities of some enzymes.
Advances in experimental medicine and biology 1991;309B():337-40.
1991: Duley J A; Simmonds H A
Superactive UMP hydrolase: cause or consequence of haemolytic anaemia?
Advances in experimental medicine and biology 1991;309B():315-8.
1991: Morgan G; Strobel S; Montero C; Duley J A; Davies P M; Simmonds H A
Raised IMP-dehydrogenase activity in the erythrocytes of a case of purine nucleoside phosphorylase (PNP) deficiency.
Advances in experimental medicine and biology 1991;309B():297-300.
1991: Sestini S; Pescaglini M; Magagnoli C; Jacomelli G; Rocchigiani M; Simmonds H A
NAD synthesis in human erythrocytes: study of adenylyl transferase activities in patients bearing purine enzyme disorders.
Advances in experimental medicine and biology 1991;309B():319-22.
1990: Montero C; Smolenski R T; Duley J A; Simmonds H A
S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase.
Biochemical pharmacology 1990;40(12):2617-23.
1990: Micheli V; Simmonds H A; Sestini S; Ricci C
Importance of nicotinamide as an NAD precursor in the human erythrocyte.
Archives of biochemistry and biophysics 1990;283(1):40-5.
1990: Simmonds H A; Micheli V; Davies P M; McBride M B
Erythrocyte nucleotide stability and plasma hypoxanthine concentrations: improved ATP stability with short-term storage at room temperature.
Clinica chimica acta; international journal of clinical chemistry 1990;192(2):121-32.
1990: Calabrese G; Simmonds H A; Cameron J S; Davies P M
Precocious familial gout with reduced fractional urate clearance and normal purine enzymes.
The Quarterly journal of medicine 1990;75(277):441-50.
1990: Duley J A; Simmonds H A; Hopkinson D A; Levinsky R J
Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency.
Clinica chimica acta; international journal of clinical chemistry 1990;188(3):243-52.
1990: Fairbanks L D; Taddeo A; Duley J A; Simmonds H A
Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):485-91.
1989: Simmonds H A; Cameron J S; Barratt T M; Dillon M J; Meadow S R; Trompeter R S
Purine enzyme defects as a cause of acute renal failure in childhood.
Pediatric nephrology (Berlin, Germany) 1989;3(4):433-7.
1989: Simmonds H A; Fairbanks L D; Duley J A; Morris G S
ATP formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and S-adenosylhomocysteine hydrolase.
Bioscience reports 1989;9(1):75-85.
1989: Simmonds H A; Micheli V; Duley J A; Fairbanks L D; Hopkinson D A; Levinsky R J
Further evidence for a 'new' purine defect, inosine triphosphate (ITP) pyrophosphohydrolase deficiency.
Advances in experimental medicine and biology 1989;253A():97-102.
1989: Taddeo A; Fairbanks L D; Simmonds H A; Duley J A; Morris G S
Deoxy GTP accumulates in thymocytes, but not in T or B lymphocytes in simulated PNP deficiency.
Advances in experimental medicine and biology 1989;253B():275-80.
1988: Simmonds H A; Fairbanks L D; Morris G S; Webster D R; Harley E H
Altered erythrocyte nucleotide patterns are characteristic of inherited disorders of purine or pyrimidine metabolism.
Clinica chimica acta; international journal of clinical chemistry 1988;171(2-3):197-210.
1987: Morgan G; Levinsky R J; Hugh-Jones K; Fairbanks L D; Morris G S; Simmonds H A
Heterogeneity of biochemical, clinical and immunological parameters in severe combined immunodeficiency due to adenosine deaminase deficiency.
Clinical and experimental immunology 1987;70(3):491-9.
1987: Morris G S; Simmonds H A; Toseland P A; Van Acker K J; Davies P M; Stuchbury J H
Urinary oxalate levels are not affected by dietary purine intake or allopurinol.
British journal of urology 1987;60(4):292-300.
1987: Dooley T; Fairbanks L D; Simmonds H A; Rodeck C H; Nicolaides K H; Soothill P W; Stewart P; Morgan G; Levinsky R J
First trimester diagnosis of adenosine deaminase deficiency.
Prenatal diagnosis 1987;7(8):561-5.
1987: Simmonds H A; Fairbanks L D; Morris G S; Morgan G; Watson A R; Timms P; Singh B
Central nervous system dysfunction and erythrocyte guanosine triphosphate depletion in purine nucleoside phosphorylase deficiency.
Archives of disease in childhood 1987;62(4):385-91.
1987: Simmonds H A; Cameron J S; Morris G S; Fairbanks L D; Davies P M
Purine metabolites in uraemia.
Advances in experimental medicine and biology 1987;223():73-80.
1987: Fairbanks L D; Simmonds H A; Webster D R
Use of intact erythrocytes in the diagnosis of inherited purine and pyrimidine disorders.
Journal of inherited metabolic disease 1987;10(2):174-86.
1986: Simmonds H A; Cameron J S; Morris G S; Davies P M
Allopurinol in renal failure and the tumour lysis syndrome.
Clinica chimica acta; international journal of clinical chemistry 1986;160(2):189-95.
1986: Morris G S; Simmonds H A; Davies P M
Use of biological fluids for the rapid diagnosis of potentially lethal inherited disorders of human purine and pyrimidine metabolism.
Biomedical chromatography : BMC 1986;1(3):109-18.
1986: Carapella De Luca E; Stegagno M; Dionisi Vici C; Paesano R; Fairbanks L D; Morris G S; Simmonds H A
Prenatal exclusion of purine nucleoside phosphorylase deficiency.
European journal of pediatrics 1986;145(1-2):51-3.
1986: Simmonds H A; Fairbanks L D; Morris G S; Hugh-Jones K; Morgan G; Levinsky R J
Correlations between purine levels, clinical and immunological status in ADA deficiency.
Advances in experimental medicine and biology 1986;195 Pt A():93-9.
1986: Becroft D M; Webster D R; Simmonds H A; Fairbanks L D; Wilson J D; Phillips L I
Hereditary orotic aciduria: further biochemistry.
Advances in experimental medicine and biology 1986;195 Pt A():67-70.
1986: Goday A; Simmonds H A; Fairbanks L D; Morris G S
B-lymphocytes, thymocytes and platelets accumulate high dATP levels in simulated ADA deficiency.
Advances in experimental medicine and biology 1986;195 Pt A():515-20.
1986: Simmonds H A; Fairbanks L D; Morris G S; Timms P; Singh B; Bold A
Erythrocyte GTP depletion in PNP deficiency presenting with haemolytic anaemia and hypouricaemia.
Advances in experimental medicine and biology 1986;195 Pt A():481-6.
1986: Fairbanks L D; Simmonds H A; Webster D R
Usefulness of intact erythrocyte studies in the diagnosis of inherited purine and pyrimidine defects.
Advances in experimental medicine and biology 1986;195 Pt A():101-7.
1985: Goday A; Simmonds H A; Morris G S; Fairbanks L D
Human B lymphocytes and thymocytes but not peripheral blood mononuclear cells accumulate high dATP levels in conditions simulating ADA deficiency.
Biochemical pharmacology 1985;34(19):3561-9.
1985: Simmonds H A; Goday A; Morris G S
Superoxide radicals, immunodeficiency and xanthine oxidase activity: man is not a mouse!
Clinical science (London, England : 1979) 1985;68(5):561-5.
1985: Goday A; Simmonds H A; Webster D R; Morris G S
EHNA is a poor inhibitor of deoxyadenosine catabolism in cultured human lymphocytes.
Revista española de fisiología 1985;41(1):49-54.
1984: Simmonds H A; Goday A; Morris G S; Fairbanks L D; Levinsky R J
dATP accumulation and ATP depletion in platelets in adenosine deaminase deficiency: significance for the immune response?
Bioscience reports 1984;4(10):809-18.
1984: Goday A; Simmonds H A; Morris G S; Fairbanks L D
B cells as well as T cells form deoxynucleotides from either deoxyadenosine or deoxyguanosine.
Clinical and experimental immunology 1984;56(1):39-48.
1984: Simmonds H A; Goday A; Morris G S; Brolsma M F
Metabolism of deoxynucleosides by lymphocytes in long-term culture deficient in different purine enzymes.
Biochemical pharmacology 1984;33(5):763-70.
1984: Goday A; Webster D R; Simmonds H A; Levinsky R J; Perrett D; Brown Z; Reiter S; Watson A R
Nucleotide levels in peripheral blood mononuclear cells of immunodeficient children: problems of measurement.
Advances in experimental medicine and biology 1984;165 Pt B():179-82.
1984: Cameron J S; Simmonds H A; Webster D R; Wass V; Sahota A
Problems of diagnosis in an adolescent with hypoxanthine-guanine phosphoribosyltransferase deficiency and acute renal failure.
Advances in experimental medicine and biology 1984;165 Pt A():7-12.
1984: Simmonds H A; Gibson T; Huston G J; Webster D R; Rodgers A V; Munro J
Gout resistant to allopurinol: poor compliance or non-response.
Advances in experimental medicine and biology 1984;165 Pt A():171-4.
1984: Becroft D M; Barry D M; Webster D R; Simmonds H A
Failure of protein loading tests to identify heterozygosity for ornithine carbamoyltransferase deficiency.
Journal of inherited metabolic disease 1984;7(4):157-9.
1984: Fairbanks L D; Webster D R; Simmonds H A; Potter C F; Watson A R
Inosine formation from hypoxanthine by intact erythrocytes and fibroblasts of an immunodeficient child with purine nucleoside phosphorylase deficiency.
Advances in experimental medicine and biology 1984;165 Pt B():167-70.
1984: Watson A R; Simmonds H A; Webster D R; Layward L; Evans D I
Purine nucleoside phosphorylase (PNP) deficiency: a therapeutic challenge.
Advances in experimental medicine and biology 1984;165 Pt A():53-9.
1984: Simmonds H A; Webster D R; Wilson J; Potter C F; Fairbanks L D
Evidence of a new syndrome involving hereditary uric acid over-production, neurological complications and deafness.
Advances in experimental medicine and biology 1984;165 Pt A():97-102.
1983: Goday A; Simmonds H A; Webster D R; Levinsky R J; Watson A R; Hoffbrand A V
Importance of platelet-free preparations for evaluating lymphocyte nucleotide levels in inherited or acquired immunodeficiency syndromes.
Clinical science (London, England : 1979) 1983;65(6):635-43.
1983: Fairbanks L D; Goday A; Morris G S; Brolsma M F; Simmonds H A; Gibson T
Rapid determination of purine enzyme activity in intact and lysed cells using high-performance liquid chromatography with and without radiolabelled substrates.
Journal of chromatography 1983;276(2):427-32.
1983: Reiter S; Simmonds H A; Webster D R; Watson A R
On the metabolism of allopurinol. Formation of allopurinol-1-riboside in purine nucleoside phosphorylase deficiency.
Biochemical pharmacology 1983;32(14):2167-74.
1983: Sahota A; Webster D R; Potter C F; Simmonds H A; Rodgers A V; Gibson T
Methylthioadenosine phosphorylase activity in human erythrocytes.
Clinica chimica acta; international journal of clinical chemistry 1983;128(2-3):283-90.
1983: Simmonds H A; Fairbanks L D; Webster D R; Rodeck C H; Linch D C; Levinsky R J
Rapid prenatal diagnosis of adenosine deaminase deficiency and other purine disorders using foetal blood.
Bioscience reports 1983;3(1):31-8.
1982: Simmonds H A; Watson A R; Webster D R; Sahota A; Perrett D
GTP depletion and other erythrocyte abnormalities in inherited PNP deficiency.
Biochemical pharmacology 1982;31(6):941-6.
1981: Perrett D; Sahota A; Simmonds H A; Hugh-Jones K
Deoxyadenosine metabolism in the erythrocytes of children with severe, combined immunodeficiency.
Bioscience reports 1981;1(12):933-44.
1981: Webster D R; Simmonds H A; Barry D M; Becroft D M
Pyrimidine and purine metabolites in ornithine carbamoyl transferase deficiency.
Journal of inherited metabolic disease 1981;4(1):27-31.
1980: Simmonds H A; Webster D R; Becroft D M; Potter C F
Purine and pyrimidine metabolism in hereditary orotic aciduria: some unexpected effects of allopurinol.
European journal of clinical investigation 1980;10(4):333-9.
1980: Van Acker K J; Simmonds H A; Potter C F; Sahota A
Inheritance of adenine phosphoribosyltransferase (APRT) deficiency.
Advances in experimental medicine and biology 1980;122A():349-53.
1980: Simmonds H A; Barratt T M; Webster D R; Sahota A; Van Acker K J; Cameron J S; Dillon M
Spectrum of 2,8-dihydroxyadenine urolithiasis in complete APRT deficiency.
Advances in experimental medicine and biology 1980;122A():337-41.
1980: Sahota A; Simmonds H A; Potter C F; Watson J G; Hugh-Jones K; Perrett D
Adenosine and deoxyadenosine metabolism in the erythrocytes of a patient with adenosine deaminase deficiency.
Advances in experimental medicine and biology 1980;122A():397-401.

Sign-in to see more