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Hollis Simmons

Research Profile

Procedures

Ovariectomy

Living Beings

Concepts & Ideas

Bone Density

Chemicals & Drugs

Anatomy

Physiology

Disorders

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Publications

TOP 3
Leonard Buckbinder; D Todd Crawford; Hong Qi; Hua Zhu Ke; Lisa M Olson; Kelly R Long; Peter C Bonnette; Amy P Baumann; John E Hambor; William A Grasser; Lydia C Pan; Thomas A Owen; Michael J Luzzio; Catherine A Hulford; David F Gebhard; Vishwas M Paralkar; Hollis A Simmons; John C Kath; W Gregory Roberts; Steven L Smock; Angel Guzman-Perez; Thomas Brown; Mei Li
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Mei Li; Lydia C Pan; Hollis A Simmons; Yan Li; David R Healy; B S Robinson; Hua Zhu Ke; Thomas Brown
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.
Xiao-Ning Wang; Hollis A Simmons; Christopher T Salatto; Patricia G Cosgrove; David D Thompson
Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.

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2007: Leonard Buckbinder; D Todd Crawford; Hong Qi; Hua Zhu Ke; Lisa M Olson; Kelly R Long; Peter C Bonnette; Amy P Baumann; John E Hambor; William A Grasser; Lydia C Pan; Thomas A Owen; Michael J Luzzio; Catherine A Hulford; David F Gebhard; Vishwas M Paralkar; Hollis A Simmons; John C Kath; W Gregory Roberts; Steven L Smock; Angel Guzman-Perez; Thomas Brown; Mei Li
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10619-24.
2006: Mei Li; Lydia C Pan; Hollis A Simmons; Yan Li; David R Healy; B S Robinson; Hua Zhu Ke; Thomas Brown
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.
Bone 2006;39(4):796-806.
2006: Xiao-Ning Wang; Hollis A Simmons; Christopher T Salatto; Patricia G Cosgrove; David D Thompson
Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.
Menopause (New York, N.Y.) 2006;13(4):609-20.
2006: Hua Zhu Ke; D Todd Crawford; Hong Qi; Hollis A Simmons; Thomas A Owen; Vishwas M Paralkar; Mei Li; Bihong Lu; William A Grasser; Kimberly O Cameron; Bruce A Lefker; Paul DaSilva-Jardine; Dennis O Scott; Qing Zhang; Xiao Yan Tian; Webster S S Jee; Thomas Brown; David D Thompson
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):565-75.
2005: Hua Zhu Ke; Hong Qi; D Todd Crawford; Hollis A Simmons; Gang Xu; Mei Li; Lori A Plum; Margaret Clagett-Dame; Hector F Deluca; David D Thompson; Thomas Brown
A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(10):1742-55.
2005: Mei Li; David R Healy; Yan Li; Hollis A Simmons; D Todd Crawford; Hua Zhu Ke; Lydia C Pan; Thomas Brown; David D Thompson
Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice.
Bone 2005;37(1):46-54.
2004: Tomoko Maeda; Hua Zhu Ke; Hollis A Simmons; David Thompson
[Lasofoxifene, a next generation estrogen receptor modulator: preclinical studies].
Clinical calcium 2004;14(10):85-93.
2004: Hua Zhu Ke; George L Foley; Hollis A Simmons; Victor Shen; David D Thompson
Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats.
Endocrinology 2004;145(4):1996-2005.
2004: Mei Li; David R Healy; Yan Li; Hollis A Simmons; M Su; Webster S S Jee; Victor Shen; David D Thompson
Alfacalcidol prevents age-related bone loss and causes an atypical pattern of bone formation in aged male rats.
Journal of musculoskeletal & neuronal interactions 2004;4(1):22-32.
2003: Mei Li; David R Healy; Hollis A Simmons; Hua Zhu Ke; David D Thompson
Alfacalcidol restores cancellous bone in ovariectomized rats.
Journal of musculoskeletal & neuronal interactions 2003;3(1):39-46.
2003: Lori C Gowen; Donna N Petersen; Amy L Mansolf; Hong Qi; Jeffrey L Stock; George T Tkalcevic; Hollis A Simmons; D Todd Crawford; Kristin L Chidsey-Frink; Hua Zhu Ke; John McNeish; Thomas Brown
Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.
The Journal of biological chemistry 2003;278(3):1998-2007.
2002: Hua Zhu Ke; Thomas Brown; Hong Qi; D Todd Crawford; Hollis A Simmons; Donna N Petersen; Melanie R Allen; John McNeish; David D Thompson
The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice.
Journal of musculoskeletal & neuronal interactions 2002;2(5):479-88.
2001: Mei Li; David R Healy; Yan Li; Hollis A Simmons; F Gao; Hua Zhu Ke; B Lu; Thomas A Owen; David D Thompson
A comparison of the anabolic effects of rat and bovine parathyroid hormone (1-34) in ovariectomized rats.
Journal of musculoskeletal & neuronal interactions 2001;2(1):77-83.
2001: Hua Zhu Ke; D Todd Crawford; Hong Qi; Kristin L Chidsey-Frink; Hollis A Simmons; Mei Li; Webster S S Jee; David D Thompson
Long-term effects of aging and orchidectomy on bone and body composition in rapidly growing male rats.
Journal of musculoskeletal & neuronal interactions 2001;1(3):215-24.
2000: Hua Zhu Ke; Hong Qi; D Todd Crawford; Kristin L Chidsey-Frink; Hollis A Simmons; David D Thompson
Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat.
Endocrinology 2000;141(4):1338-44.
1999: Hua Zhu Ke; D Todd Crawford; Hong Qi; Christine M Pirie; Hollis A Simmons; Kristin L Chidsey-Frink; HK Chen; Webster S S Jee; David D Thompson
Droloxifene does not blunt bone anabolic effects of prostaglandin E2, but maintains prostaglandin E2-restored bone in aged, ovariectomized rats.
Bone 1999;24(1):41-7.
1998: Hua Zhu Ke; Victor Shen; Hong Qi; D Todd Crawford; DD Wu; XG Liang; Kristin L Chidsey-Frink; Christine M Pirie; Hollis A Simmons; David D Thompson
Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia.
Bone 1998;23(3):249-55.
1998: Robert L Rosati; P Da Silva Jardine; Kimberly O Cameron; David D Thompson; Hua Zhu Ke; Steven M Toler; Thomas Brown; Lydia C Pan; C F Ebbinghaus; A R Reinhold; N C Elliott; B N Newhouse; C M Tjoa; P M Sweetnam; MJ Cole; M W Arriola; J W Gauthier; D Todd Crawford; David F Nickerson; Christine M Pirie; Hong Qi; Hollis A Simmons; George T Tkalcevic
Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene.
Journal of medicinal chemistry 1998;41(16):2928-31.
1998: Hollis A Simmons; Christine M Pirie; David D Thompson; Hua Zhu Ke
Parathyroid hormone (1-34) increased total body bone mass in aged female rats.
The Journal of pharmacology and experimental therapeutics 1998;286(1):341-4.
1998: Hua Zhu Ke; Vishwas M Paralkar; William A Grasser; D Todd Crawford; Hong Qi; Hollis A Simmons; Christine M Pirie; Kristin L Chidsey-Frink; Thomas A Owen; Steven L Smock; HK Chen; Webster S S Jee; Kimberly O Cameron; Robert L Rosati; Thomas Brown; Paul DaSilva-Jardine; David D Thompson
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.
Endocrinology 1998;139(4):2068-76.
1997: Hua Zhu Ke; HK Chen; Hollis A Simmons; Hong Qi; D Todd Crawford; Christine M Pirie; Kristin L Chidsey-Frink; YF Ma; Webster S S Jee; David D Thompson
Comparative effects of droloxifene, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model.
Bone 1997;20(1):31-9.
1995: Hua Zhu Ke; H K Chen; Hong Qi; Christine M Pirie; Hollis A Simmons; YF Ma; Webster S S Jee; David D Thompson
Effects of droloxifene on prevention of cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats.
Bone 1995;17(5):491-6.
1995: H K Chen; Hua Zhu Ke; C H Lin; YF Ma; Hong Qi; D Todd Crawford; Christine M Pirie; Hollis A Simmons; Webster S S Jee; David D Thompson
Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats.
Bone 1995;17(4 Suppl):175S-179S.
1995: David D Thompson; Hollis A Simmons; Christine M Pirie; Hua Zhu Ke
FDA Guidelines and animal models for osteoporosis.
Bone 1995;17(4 Suppl):125S-133S.
1995: H K Chen; Hua Zhu Ke; Webster S S Jee; YF Ma; Christine M Pirie; Hollis A Simmons; David D Thompson
Droloxifene prevents ovariectomy-induced bone loss in tibiae and femora of aged female rats: a dual-energy X-ray absorptiometric and histomorphometric study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(8):1256-62.
1995: Hua Zhu Ke; Hollis A Simmons; Christine M Pirie; D Todd Crawford; David D Thompson
Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats.
Endocrinology 1995;136(6):2435-41.