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Paul Simmons

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Vanta J Jokubaitis; Lidia Sinka; Rebecca Driessen; Genevieve Whitty; David N Haylock; Ivan Bertoncello; Ian Smith; Bruno Péault; Manuela Tavian; Paul J Simmons
Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues.
Stan Gronthos; Stephen Fitter; Peter Diamond; Paul J Simmons; Silviu Itescu; Andrew C W Zannettino
A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells.
Sharon H A Wong; Kym N Lowes; Ivan Bertoncello; Anita F Quigley; Paul J Simmons; Mark J Cook; Andrew J Kornberg; Robert Kapsa
Evaluation of Sca-1 and c-Kit as selective markers for muscle remodelling by nonhemopoietic bone marrow cells.

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2008: Vanta J Jokubaitis; Lidia Sinka; Rebecca Driessen; Genevieve Whitty; David N Haylock; Ivan Bertoncello; Ian Smith; Bruno Péault; Manuela Tavian; Paul J Simmons
Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues.
Blood 2008;111(8):4055-63.
2007: Stan Gronthos; Stephen Fitter; Peter Diamond; Paul J Simmons; Silviu Itescu; Andrew C W Zannettino
A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells.
Stem cells and development 2007;16(6):953-63.
2007: Sharon H A Wong; Kym N Lowes; Ivan Bertoncello; Anita F Quigley; Paul J Simmons; Mark J Cook; Andrew J Kornberg; Robert Kapsa
Evaluation of Sca-1 and c-Kit as selective markers for muscle remodelling by nonhemopoietic bone marrow cells.
Stem cells (Dayton, Ohio) 2007;25(6):1364-74.
2007: David N Haylock; Brenda Williams; Hayley M Johnston; Mira C P Liu; Kate E Rutherford; Genevieve A Whitty; Paul J Simmons; Ivan Bertoncello; Susan K Nilsson
Hemopoietic stem cells with higher hemopoietic potential reside at the bone marrow endosteum.
Stem cells (Dayton, Ohio) 2007;25(4):1062-9.
2006: Susan K Nilsson; Paul J Simmons; Ivan Bertoncello
Hemopoietic stem cell engraftment.
Experimental hematology 2006;34(2):123-9.
2005: Craig L Semerad; Matthew J Christopher; Fulu Liu; Brenton Short; Paul J Simmons; Ingrid Winkler; Jean-Pierre Levesque; Jean Chappel; F Patrick Ross; Daniel C Link
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.
Blood 2005;106(9):3020-7.
2005: Susan K Nilsson; Hayley M Johnston; Genevieve A Whitty; Brenda Williams; Ryan J Webb; David T Denhardt; Ivan Bertoncello; Linda Bendall; Paul J Simmons; David N Haylock
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.
Blood 2005;106(4):1232-9.
2005: B Jorgensen-Tye; Jean-Pierre Levesque; L Royle; R Doyonnas; J Y-H Chan; Raymond A Dwek; Pauline M Rudd; David Harvey; Paul J Simmons; Suzanne M Watt
Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis.
Tissue antigens 2005;65(3):220-39.
2004: H Miles Prince; Paul J Simmons; Genevieve A Whitty; Dominic P Wall; Lesley Barber; Guy C Toner; John F Seymour; Gary Richardson; Robert Mrongovius; David N Haylock
Improved haematopoietic recovery following transplantation with ex vivo-expanded mobilized blood cells.
British journal of haematology 2004;126(4):536-45.
2004: Jean-Pierre Levesque; Fulu Liu; Paul J Simmons; Tomoko Betsuyaku; Robert M Senior; Christine Pham; Daniel C Link
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Blood 2004;104(1):65-72.
2004: Susan K Nilsson; Paul J Simmons
Transplantable stem cells: home to specific niches.
Current opinion in hematology 2004;11(2):102-6.
2004: Ingrid G Winkler; Karen R. Snapp; Paul J Simmons; Jean-Pierre Lévesque
Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.
Blood 2004;103(5):1685-92.
2003: Brenton Short; Nathalie Brouard; Teresa Occhiodoro-Scott; Anand Ramakrishnan; Paul J Simmons
Mesenchymal stem cells.
Archives of medical research 2003;34(6):565-71.
2003: Linda Bendall; Alexander James; Andrew C W Zannettino; Paul J Simmons; David J Gottlieb; Kenneth F Bradstock
A novel CD44 antibody identifies an epitope that is aberrantly expressed on acute lymphoblastic leukaemia cells.
Immunology and cell biology 2003;81(4):311-9.
2003: Andrew C W Zannettino; Kate Harrison; Clive J Joyner; James T Triffitt; Paul J Simmons
Molecular cloning of the cell surface antigen identified by the osteoprogenitor-specific monoclonal antibody, HOP-26.
Journal of cellular biochemistry 2003;89(1):56-66.
2003: Stan Gronthos; Andrew C W Zannettino; Shelley J Hay; Songtao Shi; Stephen E Graves; Angela Kortesidis; Paul J Simmons
Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.
Journal of cell science 2003;116(Pt 9):1827-35.
2003: Andrew C W Zannettino; Maria Roubelakis; Katie Welldon; Denise E Jackson; Paul J Simmons; Linda Bendall; Anthony Henniker; Kate L Harrison; Silvana Niutta; Kenneth F Bradstock; Suzanne M Watt
Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.
The Biochemical journal 2003;370(Pt 2):537-49.
2003: Jean-Pierre Lévesque; Jean Hendy; Ingrid G Winkler; Yasushi Takamatsu; Paul J Simmons
Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells.
Experimental hematology 2003;31(2):109-17.
2003: Susan K Nilsson; David N Haylock; Hayley M Johnston; Teresa Occhiodoro; Tracey Brown; Paul J Simmons
Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro.
Blood 2003;101(3):856-62.
2003: Jean-Pierre Lévesque; Jean Hendy; Yasushi Takamatsu; Paul J Simmons; Linda Bendall
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.
The Journal of clinical investigation 2003;111(2):187-96.
2002: Jean-Pierre Lévesque; Yoshikazu Takada; Wilma Puzon-McLaughlin; Paul J Simmons
A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29).
Hybridoma and hybridomics 2002;21(4):253-60.
2002: Jean-Pierre Lévesque; Jean Hendy; Yasushi Takamatsu; Brenda Williams; Ingrid G Winkler; Paul J Simmons
Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment.
Experimental hematology 2002;30(5):440-9.
2001: Paul J Simmons; Andrew C W Zannettino; D Harrison-Findik; BW Swart; Stephen Tomlinson; B Hill; J A Javni
A novel epitope of CD59 expressed by primitive human hematopoietic progenitors.
Experimental hematology 2001;29(12):1474-83.
2001: Jean-Pierre Lévesque; Yasushi Takamatsu; Susan K Nilsson; David N Haylock; Paul J Simmons
Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.
Blood 2001;98(5):1289-97.
2001: H S Ramshaw; David N Haylock; BW Swart; Stan Gronthos; MJ Horsfall; Silvana Niutta; Paul J Simmons
Monoclonal antibody BB9 raised against bone marrow stromal cells identifies a cell-surface glycoprotein expressed by primitive human hemopoietic progenitors.
Experimental hematology 2001;29(8):981-92.
2001: Paul J Simmons; Jean-Pierre Levesque; David N Haylock
Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells.
Annals of the New York Academy of Sciences 2001;938():196-206; discussion 206-7.
2001: Stan Gronthos; Paul J Simmons; Stephen E Graves; Pamela Robey
Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix.
Bone 2001;28(2):174-81.
2001: J Y-H Chan; Jane Lee-Prudhoe; B Jorgensen; G Ihrke; R Doyonnas; Andrew C W Zannettino; Veronica Buckle; C J Ward; Paul J Simmons; Suzanne M Watt
Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.
The Journal of biological chemistry 2001;276(3):2139-52.
2001: B Short; N Brouard; R Driessen; Paul J Simmons
Prospective isolation of stromal progenitor cells from mouse BM.
Cytotherapy 2001;3(5):407-8.
2000: R Doyonnas; J Yi-Hsin Chan; LH Butler; I Rappold; Jane Lee-Prudhoe; Andrew C W Zannettino; Paul J Simmons; Hans-Jörg Bühring; Jean-Pierre Levesque; Suzanne M Watt
CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):840-51.
2000: MJ Horsfall; Chi-hung Hui; L Bik To; C G Begley; Russell L Basser; Paul J Simmons
Combination of stem cell factor and granulocyte colony-stimulating factor mobilizes the highest number of primitive haemopoietic progenitors as shown by pre-colony-forming unit (pre-CFU) assay.
British journal of haematology 2000;109(4):751-8.
2000: Suzanne M Watt; LH Butler; Manuela Tavian; Hans-Jörg Bühring; I Rappold; Paul J Simmons; Andrew C W Zannettino; D Buck; A Fuchs; R Doyonnas; J Y-H Chan; Jean-Pierre Levesque; Bruno Peault; Ioannis Roxanis
Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues.
Blood 2000;95(10):3113-24.
2000: Denis Corbeil; Katja Röper; Andrea Hellwig; Manuela Tavian; S Miraglia; Suzanne M Watt; Paul J Simmons; Bruno Peault; DW Buck; Wieland B Huttner
The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions.
The Journal of biological chemistry 2000;275(8):5512-20.
1999: Hans-Jörg Bühring; Paul J Simmons; M Pudney; Robert Müller; D Jarrossay; A van Agthoven; M Willheim; Wolfram Brugger; Peter Valent; Lothar Kanz
The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors.
Blood 1999;94(7):2343-56.
1999: Jean-Pierre Lévesque; Andrew C W Zannettino; M Pudney; Silvana Niutta; David N Haylock; Karen R. Snapp; Geoffrey S Kansas; M C Berndt; Paul J Simmons
PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis.
Immunity 1999;11(3):369-78.
1999: J P Lévesque; Paul J Simmons
Cytoskeleton and integrin-mediated adhesion signaling in human CD34+ hemopoietic progenitor cells.
Experimental hematology 1999;27(4):579-86.
1999: M M Roberts; BW Swart; Paul J Simmons; Russell L Basser; C G Begley; L Bik To
Prolonged release and c-kit expression of haemopoietic precursor cells mobilized by stem cell factor and granulocyte colony stimulating factor.
British journal of haematology 1999;104(4):778-84.
1999: Stan Gronthos; Andrew C W Zannettino; Stephen E Graves; S Ohta; Shelley J Hay; Paul J Simmons
Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(1):47-56.
1998: A K Lie; Chi-hung Hui; Trevor Rawling; PG Dyson; D Thorp; J Benic; C M Rawling; IR Toogood; Noemi Horvath; Paul J Simmons; L Bik To
Granulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilization in patients who had failed initial mobilization with chemotherapy and G-CSF.
Bone marrow transplantation 1998;22(9):853-7.
1998: Yasushi Takamatsu; Paul J Simmons; R J Moore; H A Morris; L Bik To; Jean-Pierre Lévesque
Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization.
Blood 1998;92(9):3465-73.
1998: Andrew C W Zannettino; Hans-Jörg Bühring; Silvana Niutta; Suzanne M Watt; M A Benton; Paul J Simmons
The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis.
Blood 1998;92(8):2613-28.
1998: S Moore; David N Haylock; Jean-Pierre Lévesque; LA McDiarmid; L M Samels; L Bik To; Paul J Simmons; Timothy P Hughes
Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells.
Blood 1998;92(7):2461-70.
1998: Suzanne M Watt; Hans-Jörg Bühring; I Rappold; J Y-H Chan; Jane Lee-Prudhoe; T Jones; Andrew C W Zannettino; Paul J Simmons; R Doyonnas; Denise Sheer; LH Butler
CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21.
Blood 1998;92(3):849-66.
1998: Yasushi Takamatsu; Paul J Simmons; Jean-Pierre Lévesque
Dual control by divalent cations and mitogenic cytokines of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity expressed by human hemopoietic cells.
Cell adhesion and communication 1998;5(5):349-66.
1998: Robin Filshie; Andrew C W Zannettino; V Makrynikola; Stan Gronthos; A J Henniker; Linda Bendall; David J Gottlieb; Paul J Simmons; Kenneth F Bradstock
MUC18, a member of the immunoglobulin superfamily, is expressed on bone marrow fibroblasts and a subset of hematological malignancies.
Leukemia 1998;12(3):414-21.
1997: S Makino; David N Haylock; T Dowse; S Trimboli; Silvana Niutta; L Bik To; CA Juttner; Paul J Simmons
Ex vivo culture of peripheral blood CD34+ cells: effects of hematopoietic growth factors on production of neutrophilic precursors.
Journal of hematotherapy 1997;6(5):475-89.
1997: David N Haylock; MJ Horsfall; T L Dowse; H S Ramshaw; Silvana Niutta; S Protopsaltis; L Peng; Christopher J Burrell; I Rappold; H J Buhring; Paul J Simmons
Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand.
Blood 1997;90(6):2260-72.
1997: Paul J Simmons; Jean-Pierre Levesque; Andrew C W Zannettino
Adhesion molecules in haemopoiesis.
Baillière's clinical haematology 1997;10(3):485-505.
1997: Stan Gronthos; K Stewart; Stephen E Graves; Shelley Hay; Paul J Simmons
Integrin expression and function on human osteoblast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(8):1189-97.
1997: I Rappold; BL Ziegler; I Köhler; Sylvie Marchetto; O Rosnet; Daniel Birnbaum; Paul J Simmons; Andrew C W Zannettino; B Hill; S Neu; W Knapp; Riitta Alitalo; Kari Alitalo; A Ullrich; Lothar Kanz; Hans-Jörg Bühring
Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase.
Blood 1997;90(1):111-25.
1997: P N Baird; Paul J Simmons
Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis.
Experimental hematology 1997;25(4):312-20.
1997: L Bik To; David N Haylock; Paul J Simmons; CA Juttner
The biology and clinical uses of blood stem cells.
Blood 1997;89(7):2233-58.
1997: Andrew C W Zannettino; G W Aylett; David Leavesley; T Pietsch; D G Chang; Paul J Simmons; Leonie K Ashman
Specificity and functional effects of antibodies to human stem cell factor.
Growth factors (Chur, Switzerland) 1997;14(1):67-79.
1996: Jean-Pierre Lévesque; David N Haylock; Paul J Simmons
Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors.
Blood 1996;88(4):1168-76.
1996: Stan Gronthos; Paul J Simmons
The biology and application of human bone marrow stromal cell precursors.
Journal of hematotherapy 1996;5(1):15-23.
1996: Andrew C W Zannettino; J R Rayner; Leonie K Ashman; Thomas J Gonda; Paul J Simmons
A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):611-20.
1995: Andrew C W Zannettino; M C Berndt; C Butcher; E C Butcher; M A Vadas; Paul J Simmons
Primitive human hematopoietic progenitors adhere to P-selectin (CD62P).
Blood 1995;85(12):3466-77.
1995: Paul J Simmons; David N Haylock
Use of hematopoietic growth factors for in vitro expansion of precursor cell populations.
Current opinion in hematology 1995;2(3):189-95.
1995: Jean-Pierre Lévesque; David Leavesley; Silvana Niutta; M Vadas; Paul J Simmons
Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins.
The Journal of experimental medicine 1995;181(5):1805-15.
1995: Stan Gronthos; Paul J Simmons
The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro.
Blood 1995;85(4):929-40.
1994: Stan Gronthos; Stephen E Graves; S Ohta; Paul J Simmons
The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors.
Blood 1994;84(12):4164-73.
1994: David N Haylock; S Makino; T L Dowse; S Trimboli; Silvana Niutta; L Bik To; CA Juttner; Paul J Simmons
Ex vivo hematopoietic progenitor cell expansion.
ImmunoMethods 1994;5(3):217-25.
1994: David Leavesley; J M Oliver; B W Swart; M C Berndt; David N Haylock; Paul J Simmons
Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4673-83.
1994: L Bik To; David N Haylock; T Dowse; Paul J Simmons; S Trimboli; Leonie K Ashman; CA Juttner
A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells.
Blood 1994;84(9):2930-9.
1994: Paul J Simmons; Andrew C W Zannettino; Stan Gronthos; D Leavesley
Potential adhesion mechanisms for localisation of haemopoietic progenitors to bone marrow stroma.
Leukemia & lymphoma 1994;12(5-6):353-63.
1994: Paul J Simmons; G W Aylett; Silvana Niutta; L Bik To; CA Juttner; Leonie K Ashman
c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture.
Experimental hematology 1994;22(2):157-65.
1994: Paul J Simmons; Stan Gronthos; Andrew C W Zannettino; S Ohta; S Graves
Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis.
Progress in clinical and biological research 1994;389():271-80.
1994: Paul J Simmons; David Leavesley; J P Levesque; B W Swart; David N Haylock; L Bik To; Leonie K Ashman; CA Juttner
The mobilization of primitive hemopoietic progenitors into the peripheral blood.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():187-201; discussion 201-2.
1992: David N Haylock; L Bik To; T L Dowse; CA Juttner; Paul J Simmons
Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage.
Blood 1992;80(6):1405-12.