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Daniel Simon

Research Profile

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Junichi Hirahashi; Keiichi Hishikawa; Shinya Kaname; Naotake Tsuboi; Yunmei Wang; Daniel I Simon; George Stavrakis; Tatsuo Shimosawa; Ling Xiao; Yutaka Nagahama; Kazuo Suzuki; Toshiro Fujita; Tanya N Mayadas
Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.
David A Morrow; Yunmei Wang; Kevin Croce; Masashi Sakuma; Marc S Sabatine; Huiyun Gao; Aruna D Pradhan; Aileen M Healy; Jacqueline Buros; Carolyn H McCabe; Peter Libby; Christopher P Cannon; Eugene Braunwald; Daniel I Simon
Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial.
Derek R Brinster; Margaretta Byrne; Campbell D Rogers; Donald S Baim; Daniel I Simon; Gregory S Couper; Lawrence H Cohn
Effectiveness of same day percutaneous coronary intervention followed by minimally invasive aortic valve replacement for aortic stenosis and moderate coronary disease ("hybrid approach").

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All Publications

2009: Junichi Hirahashi; Keiichi Hishikawa; Shinya Kaname; Naotake Tsuboi; Yunmei Wang; Daniel I Simon; George Stavrakis; Tatsuo Shimosawa; Ling Xiao; Yutaka Nagahama; Kazuo Suzuki; Toshiro Fujita; Tanya N Mayadas
Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.
Circulation 2009;120(13):1255-65.
2008: David A Morrow; Yunmei Wang; Kevin Croce; Masashi Sakuma; Marc S Sabatine; Huiyun Gao; Aruna D Pradhan; Aileen M Healy; Jacqueline Buros; Carolyn H McCabe; Peter Libby; Christopher P Cannon; Eugene Braunwald; Daniel I Simon
Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial.
American heart journal 2008;155(1):49-55.
2006: Derek R Brinster; Margaretta Byrne; Campbell D Rogers; Donald S Baim; Daniel I Simon; Gregory S Couper; Lawrence H Cohn
Effectiveness of same day percutaneous coronary intervention followed by minimally invasive aortic valve replacement for aortic stenosis and moderate coronary disease ("hybrid approach").
The American journal of cardiology 2006;98(11):1501-3.
2006: Eric Larose; Campbell D Rogers; Daniel I Simon
When size matters: lessons learned from left main stent embolization and retrieval.
Journal of interventional cardiology 2006;19(4):350-5.
2006: Aileen M Healy; Michael D Pickard; Aruna D Pradhan; Yunmei Wang; Zhiping Chen; Kevin Croce; Masashi Sakuma; Can Shi; Alexandre do Canto Zago; Joseph Garasic; Andrew I Damokosh; Tracy L Dowie; Louis Poisson; James Lillie; Peter Libby; Paul M Ridker; Daniel I Simon
Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events.
Circulation 2006;113(19):2278-84.
2005: Yunmei Wang; Masashi Sakuma; Zhiping Chen; Valentin Ustinov; Can Shi; Kevin Croce; Alexandre do Canto Zago; Jose A Lopez; Patrick Andre; Edward F Plow; Daniel I Simon
Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury.
Circulation 2005;112(19):2993-3000.
2005: John G Byrne; Marzia Leacche; Daniel Unic; James D Rawn; Daniel I Simon; Campbell D Rogers; Lawrence H Cohn
Staged initial percutaneous coronary intervention followed by valve surgery ("hybrid approach") for patients with complex coronary and valve disease.
Journal of the American College of Cardiology 2005;45(1):14-8.
2004: Nicholas Cox; Frederic S Resnic; Jeffrey J Popma; Daniel I Simon; Andrew C Eisenhauer; Campbell Rogers
Comparison of the risk of vascular complications associated with femoral and radial access coronary catheterization procedures in obese versus nonobese patients.
The American journal of cardiology 2004;94(9):1174-7.
2004: Zhiping Chen; John F Keaney; Eberhard Schulz; Bruce Levison; Lian Shan; Masashi Sakuma; Xiaobin Zhang; Can Shi; Stanley L Hazen; Daniel I Simon
Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13014-9.
2004: Can Shi; Xiaobin Zhang; Zhiping Chen; Karina Sulaiman; Mark W Feinberg; Christie M Ballantyne; Mukesh K Jain; Daniel I Simon
Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1.
The Journal of clinical investigation 2004;114(3):408-18.
2004: Jie-Hong Pan; Galina K Sukhova; Jing-Tian Yang; Bing Wang; Tao Xie; Huanxiang Fu; Yaou Zhang; Abhay R Satoskar; John R David; Christine N Metz; Richard Bucala; Kenneth Fang; Daniel I Simon; Harold A Chapman; Peter Libby; Guo-Ping Shi
Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.
Circulation 2004;109(25):3149-53.
2004: Sucharita SenBanerjee; Zhiyong Lin; G Brandon Atkins; Daniel M Greif; Ravi M Rao; Ajay Kumar; Mark W Feinberg; Zhiping Chen; Daniel I Simon; Francis W Luscinskas; Thomas Michel; Michael A Gimbrone; Guillermo García-Cardeña; Mukesh K Jain
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
The Journal of experimental medicine 2004;199(10):1305-15.
2004: Mark W Feinberg; Koichi Shimizu; Maria A Lebedeva; Richard L Haspel; Kiyoshi Takayama; Zhiping Chen; Joshua P Frederick; Xiao-Fan Wang; Daniel I Simon; Peter Libby; Richard N Mitchell; Mukesh K Jain
Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation.
Circulation research 2004;94(5):601-8.
2004: Frederick G P Welt; Sarah D Rogers; Xiaobin Zhang; Raila Ehlers; Zhiping Chen; Lisa Nannizzi-Alaimo; David R Phillips; Daniel I Simon
GP IIb/IIIa inhibition with eptifibatide lowers levels of soluble CD40L and RANTES after percutaneous coronary intervention.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2004;61(2):185-9.
2003: John C Wang; Denise Aucoin-Barry; Deborah Manuelian; Rachele Monbouquette; Mark Reisman; William Gray; Peter C Block; Elizabeth H Block; Marc Ladenheim; Daniel I Simon
Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA.
The American journal of cardiology 2003;92(12):1492-4.
2003: Raila Ehlers; Valentin Ustinov; Zhiping Chen; Xiaobin Zhang; Ravi Rao; Francis W Luscinskas; Jose A Lopez; Edward F Plow; Daniel I Simon
Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha.
The Journal of experimental medicine 2003;198(7):1077-88.
2003: Dean J Kereiakes; Arthur M Szyniszewski; Dennis Wahr; Howard C Herrmann; Daniel I Simon; Campbell Rogers; Paul Kramer; Wendy Shear; Alan C Yeung; Kendrick A Shunk; Tony M Chou; Jeffrey J Popma; Peter Fitzgerald; Tanya E Carroll; David Forer; Daniel C Adelman
Phase I drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment: procedural and long-term results.
Circulation 2003;108(11):1310-5.
2003: Haim D Danenberg; Alexander Szalai; Rajesh V Swaminathan; Lin Peng; Zhiping Chen; Philip Seifert; William P Fay; Daniel I Simon; Elazer R Edelman
Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice.
Circulation 2003;108(5):512-5.
2002: Zhiping Chen; Tatsuya Fukutomi; Alexandre do Canto Zago; Raila Ehlers; Patricia A Detmers; Samuel D Wright; Campbell Rogers; Daniel I Simon
Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids.
Circulation 2002;106(1):20-3.
2002: James L Orford; Scott Kinlay; Mark R Adams; Daniel I Simon; Andrew P Selwyn
Clopidogrel inhibits shear-induced platelet function.
Platelets 2002;13(3):187-9.
2001: Can Shi; Xiaobin Zhang; Zhiping Chen; M K Robinson; Daniel I Simon
Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity.
Circulation research 2001;89(10):859-65.
2001: Frederic S Resnic; Lucila Ohno-Machado; Andrew P Selwyn; Daniel I Simon; Jeffrey J Popma
Simplified risk score models accurately predict the risk of major in-hospital complications following percutaneous coronary intervention.
The American journal of cardiology 2001;88(1):5-9.
2001: Zhiping Chen; Kathryn W Woodburn; Can Shi; Daniel C Adelman; Campbell Rogers; Daniel I Simon
Photodynamic therapy with motexafin lutetium induces redox-sensitive apoptosis of vascular cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):759-64.
2001: Frederick G P Welt; Daniel I Simon
Atherosclerosis and plaque rupture.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2001;53(1):56-63.
2001: Daniel I Simon; C B Liu; P Ganz; J M Kirshenbaum; Robert N Piana; C Rogers ; Andrew P Selwyn; Jeffrey J Popma
A comparative study of light transmission aggregometry and automated bedside platelet function assays in patients undergoing percutaneous coronary intervention and receiving abciximab, eptifibatide, or tirofiban.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2001;52(4):425-32.
2000: Frederick G P Welt; Elazer R Edelman; Daniel I Simon; Campbell Rogers
Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2553-8.
2000: Daniel I Simon; Zhiping Chen; H Xu; C Q Li; J f Dong; Larry V McIntire; Christie M Ballantyne; Li Zhang; M I Furman; M C Berndt; J A López
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18).
The Journal of experimental medicine 2000;192(2):193-204.
2000: Daniel I Simon; Y Wei; Li Zhang; N K Rao; H Xu; Z Chen; Q Liu; S Rosenberg; H A Chapman
Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function.
The Journal of biological chemistry 2000;275(14):10228-34.
2000: Daniel I Simon; Z Dhen; Philip Seifert; Elazer R Edelman; Christie M Ballantyne; Campbell Rogers
Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty.
The Journal of clinical investigation 2000;105(3):293-300.
1999: James A de Lemos; Etienne Delacretaz; Robert N Piana; T Smith; J Rivero; Daniel I Simon; Peter L Friedman
Images in cardiovascular medicine. Ebstein's anomaly associated with an anomalous coronary artery, 2 myocardial bridges, and a mahaim fiber.
Circulation 1999;100(16):1757-9.
1999: Harold A Chapman; Y Wei; Daniel I Simon; David A Waltz
Role of urokinase receptor and caveolin in regulation of integrin signaling.
Thrombosis and haemostasis 1999;82(2):291-7.
1998: Galina Sukhova; Guo-Ping Shi; Daniel I Simon; Harold A Chapman; Peter Libby
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
The Journal of clinical investigation 1998;102(3):576-83.
1997: C R Meckel; T J Anderson; Gilbert H Mudge; Richard N Mitchell; A C Yeung; Andrew P Selwyn; Peter Ganz; Daniel I Simon
Hemostatic/fibrinolytic predictors of allograft coronary artery disease after cardiac transplantation.
Vascular medicine (London, England) 1997;2(4):306-12.
1997: Peter Libby; YJ Geng; G K Sukhova; Daniel I Simon; R T Lee
Molecular determinants of atherosclerotic plaque vulnerability.
Annals of the New York Academy of Sciences 1997;811():134-42; discussion 142-5.
1997: Daniel I Simon; H Xu; S Ortlepp; Campbell Rogers; N K Rao
7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):528-35.
1996: Daniel I Simon; N K Rao; H Xu; Y Wei; O Majdic; E Ronne; Lester Kobzik; Harold A Chapman
Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells.
Blood 1996;88(8):3185-94.
1996: Y Wei; M Lukashev; Daniel I Simon; S C Bodary; S Rosenberg; M V Doyle; Harold A Chapman
Regulation of integrin function by the urokinase receptor.
Science (New York, N.Y.) 1996;273(5281):1551-5.
1996: Daniel I Simon; M E Mullins; L Jia; Benjamin Gaston; D J Singel; Jonathan S Stamler
Polynitrosylated proteins: characterization, bioactivity, and functional consequences.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4736-41.
1996: W S Wong; Daniel I Simon; P M Rosoff; N K Rao; Harold A Chapman
Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87).
Immunology 1996;88(1):90-7.
1995: Daniel I Simon; H Xu; D E Vaughan
Cathepsin D-like aspartyl protease activity mediates the degradation of tissue-type plasminogen activator/plasminogen activator inhibitor-1 complexes in human monocytes.
Biochimica et biophysica acta 1995;1268(2):143-51.
1995: Daniel I Simon; Jonathan S Stamler; E Loh; Joseph Loscalzo; S A Francis; M A Creager
Effect of nitric oxide synthase inhibition on bleeding time in humans.
Journal of cardiovascular pharmacology 1995;26(2):339-42.
1994: Daniel I Simon; A M Ezratty; Joseph Loscalzo
The fibrin(ogen)olytic properties of cathepsin D.
Biochemistry 1994;33(21):6555-63.
1993: Daniel I Simon; A M Ezratty; S A Francis; H Rennke; Joseph Loscalzo
Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway.
Blood 1993;82(8):2414-22.
1993: Daniel I Simon; Jonathan S Stamler; O Jaraki; John F Keaney; J A Osborne; S A Francis; D J Singel; Joseph Loscalzo
Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(6):791-9.
1993: A Ezratty; Daniel I Simon; Joseph Loscalzo
Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation.
Biochemistry 1993;32(17):4628-33.
1993: John F Keaney; Daniel I Simon; Jonathan S Stamler; O Jaraki; J Scharfstein; Joseph A Vita; Joseph Loscalzo
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
The Journal of clinical investigation 1993;91(4):1582-9.
1992: Jonathan S Stamler; Daniel I Simon; O Jaraki; J A Osborne; S Francis; M Mullins; D Singel; Joseph Loscalzo
S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8087-91.
1992: Jonathan S Stamler; O Jaraki; J Osborne; Daniel I Simon; John F Keaney; Joseph A Vita; D Singel; C R Valeri; Joseph Loscalzo
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7674-7.
1992: Jonathan S Stamler; Daniel I Simon; J A Osborne; M E Mullins; O Jaraki; Thomas Michel; D J Singel; Joseph Loscalzo
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):444-8.
1991: Daniel I Simon; G M Fless; A M Scanu; Joseph Loscalzo
Tissue-type plasminogen activator binds to and is inhibited by surface-bound lipoprotein(a) and low-density lipoprotein.
Biochemistry 1991;30(27):6671-7.