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Hans-Uwe Simon

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N Echeverry; F Ke; Hans-Uwe Simon; A Strasser; D Bachmann; T Kaufmann
Intracellular localization of the BCL-2 family member BOK and functional implications.
U Gurzeler; T Rabachini; M Salmanidis; Hans-Uwe Simon; D Bachmann; G Brumatti; Clemens Dahinden; N Echeverry; P G Ekert; T Kaufmann
In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.
D Simon; Hans-Uwe Simon; Shida Yousefi
Extracellular DNA traps in allergic, infectious, and autoimmune diseases.

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All Publications

2013: N Echeverry; F Ke; Hans-Uwe Simon; A Strasser; D Bachmann; T Kaufmann
Intracellular localization of the BCL-2 family member BOK and functional implications.
Cell death and differentiation 2013;20(6):785-99.
2013: U Gurzeler; T Rabachini; M Salmanidis; Hans-Uwe Simon; D Bachmann; G Brumatti; Clemens Dahinden; N Echeverry; P G Ekert; T Kaufmann
In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.
Allergy 2013;68(5):604-13.
2013: D Simon; Hans-Uwe Simon; Shida Yousefi
Extracellular DNA traps in allergic, infectious, and autoimmune diseases.
Allergy 2013;68(4):409-16.
2013: Zhaoyue He; Hans-Uwe Simon
A novel link between p53 and ROS.
Cell cycle (Georgetown, Tex.) 2013;12(2):201-2.
2012: Hans-Uwe Simon; Steven F Ziegler
Allergic responses in the lung and skin: new players in the game.
Current opinion in immunology 2012;24(6):698-9.
2012: Shida Yousefi; Dagmar Simon; Hans-Uwe Simon
Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease.
Current opinion in immunology 2012;24(6):736-9.
2012: Bruce S Bochner; Wendy Book; William W Busse; Joseph Butterfield; Glenn T Furuta; Gerald J Gleich; Amy D Klion; James J Lee; Kristin M Leiferman; Michael Minnicozzi; Redwan Moqbel; Marc E Rothenberg; Lawrence B Schwartz; Hans-Uwe Simon; Michael E Wechsler; Peter F Weller
Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).
The Journal of allergy and clinical immunology 2012;130(3):587-96.
2012: Michael E Wechsler; Peter F Weller; Bruce S Bochner; Patricia C Fulkerson; Gail M Gauvreau; Gerald J Gleich; Tim Henkel; Roland Kolbeck; Sameer K Mathur; Hector Ortega; Jatin Patel; Calman Prussin; Paolo Renzi; Marc E Rothenberg; Florence Roufosse; Dagmar Simon; Hans-Uwe Simon; Andrew Wardlaw; Amy D Klion
Novel targeted therapies for eosinophilic disorders.
The Journal of allergy and clinical immunology 2012;130(3):563-71.
2012: M Morshed; Hans-Uwe Simon; C Stöckle; Shida Yousefi; D Simon
Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps.
Allergy 2012;67(9):1127-37.
2012: Peter Valent; Peter Vandenberghe; Peter F Weller; Michel AROCK; Joseph H Butterfield; Jason Gotlib; Torsten Haferlach; Andrzej Hellmann; Hans-Peter Horny; Amy D Klion; Kristin M Leiferman; Georgia Metzgeroth; Andreas Reiter; Florence Roufosse; Hans-Uwe Simon; Karl Sotlar; Wolfgang R Sperr; Gerald J Gleich
Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes.
The Journal of allergy and clinical immunology 2012;130(3):607-612.e9.
2012: Cristina C Mihalache; Hans-Uwe Simon
Autophagy regulation in macrophages and neutrophils.
Experimental cell research 2012;318(11):1187-92.
2012: Sébastien Conus; Cristina Pop; Guy S Salvesen; Scott J Snipas; Hans-Uwe Simon
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.
The Journal of biological chemistry 2012;287(25):21142-51.
2012: Verena Lammel; Barbara Padberg; Walter H Reinhart; Christina Stoeckle; Roland Zweifel; Dirk L Kienle; Hans-Uwe Simon
Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) 2012;76(3):493-5.
2012: Peter Valent; Peter Vandenberghe; Peter F Weller; Kristin M Leiferman; Matthias Mayerhofer; Georgia Metzgeroth; Andreas Reiter; Florence Roufosse; Hans-Uwe Simon; Karl Sotlar; Michel AROCK; Bruce S Bochner; Joseph H Butterfield; Sabine Cerny-Reiterer; Gerald J Gleich; Jason Gotlib; Torsten Haferlach; Andrzej Hellmann; Hans-Peter Horny; Amy D Klion
Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.
Expert review of hematology 2012;5(2):157-76.
2012: Hans-Uwe Simon; Amy Klion
Therapeutic approaches to patients with hypereosinophilic syndromes.
Seminars in hematology 2012;49(2):160-70.
2012: Alex Straumann; S S Aceves; C Blanchard; M H Collins; G T Furuta; I Hirano; Alain M Schoepfer; D Simon; Hans-Uwe Simon
Pediatric and adult eosinophilic esophagitis: similarities and differences.
Allergy 2012;67(4):477-90.
2012: Hans-Uwe Simon
Autophagy in myocardial differentiation and cardiac development.
Circulation research 2012;110(4):524-5.
2012: Souzan Salemi; Mihai A Constantinescu; Martin F Fey; Shida Yousefi; Hans-Uwe Simon
Autophagy is required for self-renewal and differentiation of adult human stem cells.
Cell research 2012;22(2):432-5.
2012: Stephan Von Gunten; Hans-Uwe Simon
Granulocyte death regulation by naturally occurring autoantibodies.
Advances in experimental medicine and biology 2012;750():157-72.
2012: Dagmar Simon; Hans-Uwe Simon
New drug targets in atopic dermatitis.
Chemical immunology and allergy 2012;96():126-31.
2011: Petr Hruz; Alain M Schoepfer; Hans-Uwe Simon; Alex Straumann; Marcel Zwahlen; Christoph Beglinger; Christian Bussmann; Pius Heer
Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland.
The Journal of allergy and clinical immunology 2011;128(6):1349-1350.e5.
2011: N Roth; S Hösli; M Lemann; Hans-Uwe Simon; S Städler; D Simon
Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations.
Allergy 2011;66(11):1477-86.
2011: Barbara Geering; Jan Schmidt-Mende; Elena Federzoni; Christina Stoeckle; Hans-Uwe Simon
Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransduction.
Journal of immunological methods 2011;373(1-2):209-18.
2011: Barbara Geering; Hans-Uwe Simon
A novel signaling pathway in TNFα-induced neutrophil apoptosis.
Cell cycle (Georgetown, Tex.) 2011;10(17):2821-2.
2011: B Geering; Hans-Uwe Simon
Peculiarities of cell death mechanisms in neutrophils.
Cell death and differentiation 2011;18(9):1457-69.
2011: Camilla Jandus; Hans-Uwe Simon; Stephan Von Gunten
Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy.
Biochemical pharmacology 2011;82(4):323-32.
2011: Alexander Schaub; Hans-Uwe Simon; M Spycher; Beda Stadler; Monique Vogel; Stephan Von Gunten; S Wymann; M Rüegsegger; Sylvia M Miescher
Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes.
Allergy 2011;66(8):1030-7.
2011: Barbara Geering; Ursina Gurzeler; Elena Federzoni; Thomas Kaufmann; Hans-Uwe Simon
A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.
Blood 2011;117(22):5953-62.
2011: Thomas Bieber; Hans-Uwe Simon
Allergen-specific immunotherapy: current concepts and future directions.
Allergy 2011;66(6):709-12.
2011: Cristina C Mihalache; Shida Yousefi; Sébastien Conus; Peter M Villiger; E Marion Schneider; Hans-Uwe Simon
Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion events.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6532-42.
2011: Ryszard Dworski; Hans-Uwe Simon; Aimee Hoskins; Shida Yousefi
Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways.
The Journal of allergy and clinical immunology 2011;127(5):1260-6.
2011: Alex Straumann; Sebastien Conus; Lukas Degen; Cornelia Frei; Christian Bussmann; Christoph Beglinger; Alain M Schoepfer; Hans-Uwe Simon
Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2011;9(5):400-9.e1.
2011: Sarah Casulli; Jagadeesh Bayry; Lakhdar Fattoum; Srini V Kaveri; Hans-Uwe Simon; Jean-Luc Teillaud; Selma Topçu; Stephan von Gunten; Carole Elbim
A differential concentration-dependent effect of IVIg on neutrophil functions: relevance for anti-microbial and anti-inflammatory mechanisms.
PloS one 2011;6(10):e26469.
2011: Dagmar Simon; Susanne Hoesli; Nina Roth; Simon Staedler; Shida Yousefi; Hans-Uwe Simon
Eosinophil extracellular DNA traps in skin diseases.
The Journal of allergy and clinical immunology 2011;127(1):194-9.
2010: Alex Straumann; Sebastien Conus; Lukas Degen; Stephanie Felder; Mirjam Kummer; Hansjürg Engel; Christian Bussmann; Christoph Beglinger; Alain Schoepfer; Hans-Uwe Simon
Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis.
Gastroenterology 2010;139(5):1526-37, 1537.e1.
2010: Heike Bantel; Hans-Uwe Simon
DeltaNp73beta is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria.
Cell cycle (Georgetown, Tex.) 2010;9(14):2710-1.
2010: Hans-Uwe Simon; Marc E Rothenberg; Bruce S Bochner; Peter F Weller; Andrew J Wardlaw; Michael E Wechsler; Lanny J Rosenwasser; Florence Roufosse; Gerald J Gleich; Amy D Klion
Refining the definition of hypereosinophilic syndrome.
The Journal of allergy and clinical immunology 2010;126(1):45-9.
2010: Sébastien Conus; Alex Straumann; Eva Bettler; Hans-Uwe Simon
Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis.
The Journal of allergy and clinical immunology 2010;126(1):175-7.
2010: Stephan Von Gunten; Hans-Uwe Simon
Cell death modulation by intravenous immunoglobulin.
Journal of clinical immunology 2010;30 Suppl 1():S24-30.
2010: Alain M Schoepfer; Nirmala Gonsalves; Christian Bussmann; Sébastien Conus; Hans-Uwe Simon; Alex Straumann; Ikuo Hirano
Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation.
The American journal of gastroenterology 2010;105(5):1062-70.
2010: Ahmed Z El-Hashim; Shida Yousefi; Ivan Edafiogho; Raj Raghupathy; Mariam Yousif; Hans-Uwe Simon
Anti-inflammatory and immunosuppressive effects of the enaminone E121.
European journal of pharmacology 2010;632(1-3):73-8.
2010: Adrian Britschgi; Hans-Uwe Simon; Andreas Tobler; Martin F Fey; Mario P Tschan
Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2.
British journal of haematology 2010;149(1):55-64.
2010: Jan Schmidt-Mende; Barbara Geering; Shida Yousefi; Hans-Uwe Simon
Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells.
European journal of immunology 2010;40(2):525-9.
2010: Beata Berent-Maoz; Souzan Salemi; David Mankuta; Hans-Uwe Simon; Francesca Levi-Schaffer
Human mast cells express intracellular TRAIL.
Cellular immunology 2010;262(2):80-3.
2010: Alex Straumann; S Conus; P Grzonka; H Kita; G Kephart; C Bussmann; Christoph Beglinger; D A Smith; J Patel; M Byrne; Hans-Uwe Simon
Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial.
Gut 2010;59(1):21-30.
2009: Princess U Ogbogu; Bruce S Bochner; Joseph H Butterfield; Gerald J Gleich; Johannes Huss-Marp; Jean Emmanuel Kahn; Kristin M Leiferman; Thomas B Nutman; Florian Pfab; Johannes Ring; Marc E Rothenberg; Florence Roufosse; Marie-Helene Sajous; Javed Sheikh; Dagmar Simon; Hans-Uwe Simon; Miguel L Stein; Andrew Wardlaw; Peter F Weller; Amy D Klion
Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
The Journal of allergy and clinical immunology 2009;124(6):1319-25.e3.
2009: Shida Yousefi; C Mihalache; E Kozlowski; I Schmid; Hans-Uwe Simon
Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps.
Cell death and differentiation 2009;16(11):1438-44.
2009: Stephan Von Gunten; Stephan M Jakob; Barbara Geering; Jukka Takala; Hans-Uwe Simon
Different patterns of Siglec-9-mediated neutrophil death responses in septic shock.
Shock (Augusta, Ga.) 2009;32(4):386-92.
2009: N Andina; Sébastien Conus; E M Schneider; Martin F Fey; Hans-Uwe Simon
Induction of Bim limits cytokine-mediated prolonged survival of neutrophils.
Cell death and differentiation 2009;16(9):1248-55.
2009: Shida Yousefi; Hans-Uwe Simon
Autophagy in cells of the blood.
Biochimica et biophysica acta 2009;1793(9):1461-4.
2009: S Salemi; Shida Yousefi; Dagmar Simon; I Schmid; L Moretti; L Scapozza; Hans-Uwe Simon
A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome.
Allergy 2009;64(6):913-8.
2009: Arezoo Daryadel; Shida Yousefi; David Troi; Inès Schmid; Jan Schmidt-Mende; Carlo Mordasini; Clemens Dahinden; Andrew Ziemiecki; Hans-Uwe Simon
RhoH/TTF negatively regulates leukotriene production in neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6527-32.
2009: Hans-Uwe Simon
Cell death in allergic diseases.
Apoptosis : an international journal on programmed cell death 2009;14(4):439-46.
2009: Hans-Uwe Simon; Bimal Malhotra
The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine.
Swiss medical weekly 2009;139(9-10):146-51.
2009: Nicola Andina; Svetlana Didichenko; Jan Schmidt-Mende; Clemens Dahinden; Hans-Uwe Simon
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
The Journal of allergy and clinical immunology 2009;123(3):603-11.
2009: Shida Yousefi; Hans-Uwe Simon
Autophagy in cancer and chemotherapy.
Results and problems in cell differentiation 2009;49():183-90.
2009: Sébastien Conus; Alex Straumann; Hans-Uwe Simon
Anti-IL-5 (mepolizumab) therapy does not alter IL-5 receptor alpha levels in patients with eosinophilic esophagitis.
The Journal of allergy and clinical immunology 2009;123(1):269; author reply 269-70.
2008: Sébastien Conus; Hans-Uwe Simon
Cathepsins: key modulators of cell death and inflammatory responses.
Biochemical pharmacology 2008;76(11):1374-82.
2008: Martina Ulrich; Alina Petre; Nikolay Youhnovski; Franziska Prömm; Markus Schirle; Michael Schumm; Ralph S Pero; Alfred Doyle; James Checkel; Hirohito Kita; Nethaji Thiyagarajan; K Ravi Acharya; Peter Schmid-Grendelmeier; Hans-Uwe Simon; Heinz Schwarz; Masato Tsutsui; Hiroaki Shimokawa; Gabriel Bellon; James J Lee; Michael Przybylski; Gerd Döring
Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.
The Journal of biological chemistry 2008;283(42):28629-40.
2008: Shida Yousefi; Jeffrey A Gold; Nicola Andina; James J Lee; Ann M Kelly; Evelyne Kozlowski; Inès Schmid; Alex Straumann; Janine Reichenbach; Gerald J Gleich; Hans-Uwe Simon
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense.
Nature medicine 2008;14(9):949-53.
2008: Alex Straumann; Christian Bussmann; Sébastien Conus; Christoph Beglinger; Hans-Uwe Simon
Anti-TNF-alpha (infliximab) therapy for severe adult eosinophilic esophagitis.
The Journal of allergy and clinical immunology 2008;122(2):425-7.
2008: Dagmar Simon; Jennifer Wittwer; Ganna Kostylina; Urs Buettiker; Hans-Uwe Simon; Nikhil Yawalkar
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema.
The Journal of allergy and clinical immunology 2008;122(2):423-4.
2008: Stephan von Gunten; Hans-Uwe Simon
Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg).
Autoimmunity reviews 2008;7(6):453-6.
2008: Larisa L Belyanskaya; Algirdas Ziogas; Sally Hopkins-Donaldson; Stefanie Kurtz; Hans-Uwe Simon; Rolf Stahel; Uwe Zangemeister-Wittke
TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8.
Lung cancer (Amsterdam, Netherlands) 2008;60(3):355-65.
2008: Alex Straumann; Christian Bussmann; Markus Zuber; Simone Vannini; Hans-Uwe Simon; Alain Schoepfer
Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(5):598-600.
2008: Elena Federzoni; Grace Gordon; Stefan Müller; Inès Schmid; Hans-Uwe Simon; Shida Yousefi
Expression of CD95 on mature leukocytes of MRL/lpr mice after transplantation of genetically modified bone marrow stem cells.
Immunology letters 2008;117(1):45-9.
2008: Dagmar Simon; Souzan Salemi; Shida Yousefi; Hans-Uwe Simon
Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia.
The Journal of allergy and clinical immunology 2008;121(4):1054-6.
2008: Marc E Rothenberg; Amy D Klion; Florence E Roufosse; Jean Emmanuel Kahn; Peter Weller; Hans-Uwe Simon; Lawrence B Schwartz; Lanny J Rosenwasser; Johannes Ring; Elaine F Griffin; Ann E Haig; Paul I H Frewer; Jacqueline M Parkin; Gerald J Gleich
Treatment of patients with the hypereosinophilic syndrome with mepolizumab.
The New England journal of medicine 2008;358(12):1215-28.
2008: Sébastien Conus; Remo Perozzo; Thomas Reinheckel; Christoph Peters; Leonardo Scapozza; Shida Yousefi; Hans-Uwe Simon
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
The Journal of experimental medicine 2008;205(3):685-98.
2008: B Berent-Maoz; S Salemi; David Mankuta; Hans-Uwe Simon; Francesca Levi-Schaffer
TRAIL mediated signaling in human mast cells: the influence of IgE-dependent activation.
Allergy 2008;63(3):333-40.
2008: Sébastien Conus; Hans-Uwe Simon
General laboratory diagnostics of eosinophilic GI diseases.
Best practice & research. Clinical gastroenterology 2008;22(3):441-53.
2008: Dagmar Simon; Susanne Hösli; Ganna Kostylina; Nikhil Yawalkar; Hans-Uwe Simon
Anti-CD20 (rituximab) treatment improves atopic eczema.
The Journal of allergy and clinical immunology 2008;121(1):122-8.
2007: Shida Yousefi; Hans-Uwe Simon
Apoptosis regulation by autophagy gene 5.
Critical reviews in oncology/hematology 2007;63(3):241-4.
2007: Hans-Uwe Simon; Jan Cools
Novel approaches to therapy of hypereosinophilic syndromes.
Immunology and allergy clinics of North America 2007;27(3):519-27.
2007: Akmal S Hassan; Dagmar Simon; Hans-Uwe Simon; Lasse R Braathen; Nikhil Yawalkar
Efalizumab-associated papular psoriasis.
Archives of dermatology 2007;143(7):900-6.
2007: Dagmar Simon; Hans-Uwe Simon
Eosinophilic disorders.
The Journal of allergy and clinical immunology 2007;119(6):1291-300; quiz 1301-2.
2007: Mattia Rizzi; Mario P Tschan; Christian Britschgi; Adrian Britschgi; Barbara Hügli; Tobias J Grob; Nicolas Leupin; Beatrice U Mueller; Hans-Uwe Simon; Andrew Ziemiecki; Bruce E Torbett; Martin F Fey; Andreas Tobler
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells.
Journal of leukocyte biology 2007;81(6):1599-608.
2007: Stephan Von Gunten; Monique Vogel; Alexander Schaub; Beda Stadler; Sylvia M Miescher; Paul R Crocker; Hans-Uwe Simon
Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies.
The Journal of allergy and clinical immunology 2007;119(4):1005-11.
2007: Hans-Uwe Simon; Reinhard Seger
Hyper-IgE syndrome associated with an IL-4-producing gamma/delta(+) T-cell clone.
The Journal of allergy and clinical immunology 2007;119(1):246-8.
2007: Stephan Von Gunten; Hans-Uwe Simon
Autophagic-like cell death in neutrophils induced by autoantibodies.
Autophagy 2007;3(1):67-8.
2007: Souzan Salemi; Shida Yousefi; Didier Lochmatter; Andrée Eblé; Johnny Deladoëy; Iain C A F Robinson; Hans-Uwe Simon; Primus E Mullis
Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosis.
Endocrinology 2007;148(1):45-53.
2006: Stephan Von Gunten; Alexander Schaub; Monique Vogel; Beda Stadler; Sylvia M Miescher; Hans-Uwe Simon
Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations.
Blood 2006;108(13):4255-9.
2006: Dagmar Simon; Alex Straumann; A Wenk; Hans-Peter Spichtin; Hans-Uwe Simon; Lasse R Braathen
Eosinophilic esophagitis in adults--no clinical relevance of wheat and rye sensitizations.
Allergy 2006;61(12):1480-3.
2006: Sibylla Martinelli; G Kostylina; Verena Niggli; C Baumann; Martin F Fey; H-G Wendel; Scott W Lowe; Shida Yousefi; Hans-Uwe Simon
Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils.
Oncogene 2006;25(52):6915-23.
2006: Annette Audigé; Mirjana Urosevic-Maiwald; Erika Schlaepfer; Russell Walker; Doug Powell; Sabine Hallenberger; Helen Joller; Hans-Uwe Simon; Reinhard Dummer; Roberto F Speck
Anti-HIV state but not apoptosis depends on IFN signature in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6227-37.
2006: Shida Yousefi; Remo Perozzo; Inès Schmid; Andrew Ziemiecki; Thomas Schaffner; Leonardo Scapozza; Thomas Brunner; Hans-Uwe Simon
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Nature cell biology 2006;8(10):1124-32.
2006: Arezoo Daryadel; Remo Filippo Grifone; Hans-Uwe Simon; Shida Yousefi
Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha.
The Journal of biological chemistry 2006;281(37):27653-61.
2006: Anna M Merendino; Fabio Bucchieri; Rosalia Gagliardo; Arezoo Daryadel; Flora Pompeo; Giuseppina Chiappara; Roberta Santagata; Vincenzo Bellia; Sabrina David; Felicia Farina; Donna E Davies; Hans-Uwe Simon; Antonio M Vignola
CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death.
American journal of respiratory cell and molecular biology 2006;35(2):155-64.
2006: Ekaterina Vassina; Shida Yousefi; Dagmar Simon; Caroline Zwicky; Sébastien Conus; Hans-Uwe Simon
cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis.
European journal of immunology 2006;36(7):1975-84.
2006: Amy D Klion; Bruce S Bochner; Gerald J Gleich; Thomas B Nutman; Marc E Rothenberg; Hans-Uwe Simon; Michael E Wechsler; Peter Weller
Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.
The Journal of allergy and clinical immunology 2006;117(6):1292-302.
2006: Dagmar Simon; Raija L P Lindberg; Evelyne Kozlowski; Lasse R Braathen; Hans-Uwe Simon
Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesions.
Experimental dermatology 2006;15(6):441-6.
2006: Stephan Von Gunten; Hans-Uwe Simon
Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(6):601-5.
2006: Hans-Uwe Simon
Cytokine and anti-cytokine therapy for asthma.
Current allergy and asthma reports 2006;6(2):117-21.
2006: Beata Berent-Maoz; Adrian M Piliponsky; Isabelle Daigle; Hans-Uwe Simon; Francesca Levi-Schaffer
Human mast cells undergo TRAIL-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2272-8.
2006: Hans-Uwe Simon
Molecules involved in the regulation of eosinophil apoptosis.
Chemical immunology and allergy 2006;91():49-58.
2005: Larisa L Belyanskaya; Sally Hopkins-Donaldson; Stefanie Kurtz; A Paula Simões-Wüst; Shida Yousefi; Hans-Uwe Simon; Rolf Stahel; Uwe Zangemeister-Wittke
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation.
International journal of cancer. Journal international du cancer 2005;117(5):755-63.
2005: Sébastien Conus; Andreina Bruno; Hans-Uwe Simon
Leptin is an eosinophil survival factor.
The Journal of allergy and clinical immunology 2005;116(6):1228-34.
2005: Ekaterina Vassina; Martin Leverkus; Shida Yousefi; Lasse R Braathen; Hans-Uwe Simon; Dagmar Simon
Increased expression and a potential anti-inflammatory role of TRAIL in atopic dermatitis.
The Journal of investigative dermatology 2005;125(4):746-52.
2005: Stephan Von Gunten; Shida Yousefi; Michael Seitz; Stephan M Jakob; Thomas Schaffner; Reinhard Seger; Jukka Takala; Peter M Villiger; Hans-Uwe Simon
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.
Blood 2005;106(4):1423-31.
2005: Alex Straumann; Jernej Kristl; Sébastien Conus; Ekaterina Vassina; Hans-Peter Spichtin; Christoph Beglinger; Hans-Uwe Simon
Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract.
Inflammatory bowel diseases 2005;11(8):720-6.
2005: Dagmar Simon; Ekaterina Vassina; Shida Yousefi; Lasse R Braathen; Hans-Uwe Simon
Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment.
Allergy 2005;60(7):944-51.
2005: Andreina Bruno; Sébastien Conus; Inès Schmid; Hans-Uwe Simon
Apoptotic pathways are inhibited by leptin receptor activation in neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8090-6.
2005: Jörg W Stucki; Hans-Uwe Simon
Mathematical modeling of the regulation of caspase-3 activation and degradation.
Journal of theoretical biology 2005;234(1):123-31.
2005: Dagmar Simon; Hanspeter Marti; Pius Heer; Hans-Uwe Simon; Lasse R Braathen; Alex Straumann
Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases.
The Journal of allergy and clinical immunology 2005;115(5):1090-2.
2005: Alex Straumann; Hans-Uwe Simon
Eosinophilic esophagitis: escalating epidemiology?
The Journal of allergy and clinical immunology 2005;115(2):418-9.
2005: Dagmar Simon; Lasse R Braathen; Hans-Uwe Simon
Anti-interleukin-5 antibody therapy in eosinophilic diseases.
Pathobiology : journal of immunopathology, molecular and cellular biology 2005;72(6):287-92.
2005: Günther Hofbauer; Naohito Hatta; Isabelle Daigle; Silvio Hemmi; Katharina Spanaus Schlapbach; Jörg Willers; Günter Burg; Hans-Uwe Simon; Reinhard Dummer
Fas ligand reduces viability in primary melanoma short-term cell cultures more than in metastatic melanoma short-term cell cultures.
Dermatology (Basel, Switzerland) 2005;211(4):318-24.
2005: Ariel Munitz; Ido Bachelet; Shira Fraenkel; Gil Katz; Ofer Mandelboim; Hans-Uwe Simon; Lorenzo Moretta; Marco COLONna; Francesca Levi-Schaffer
2B4 (CD244) is expressed and functional on human eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):110-8.
2004: Sibylla Martinelli; Mirjana Urosevic-Maiwald; Arezoo Daryadel; Patrick A Oberholzer; Christa Baumann; Martin F Fey; Reinhard Dummer; Hans-Uwe Simon; Shida Yousefi
Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation.
The Journal of biological chemistry 2004;279(42):44123-32.
2004: Dagmar Simon; Ekaterina Vassina; Shida Yousefi; Evelyne Kozlowski; Lasse R Braathen; Hans-Uwe Simon
Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment.
The Journal of allergy and clinical immunology 2004;114(4):887-95.
2004: Uwe Zangemeister-Wittke; Hans-Uwe Simon
An IAP in action: the multiple roles of survivin in differentiation, immunity and malignancy.
Cell cycle (Georgetown, Tex.) 2004;3(9):1121-3.
2004: Ralf Baumann; Shida Yousefi; Dagmar Simon; Stefan Russmann; Christoph Mueller; Hans-Uwe Simon
Functional expression of CD134 by neutrophils.
European journal of immunology 2004;34(8):2268-75.
2004: Frank Altznauer; Sibylla Martinelli; Shida Yousefi; Christine Thürig; Inès Schmid; Edward M Conway; Martin H Schöni; Peter Vogt; Christoph Mueller; Martin F Fey; Uwe Zangemeister-Wittke; Hans-Uwe Simon
Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils.
The Journal of experimental medicine 2004;199(10):1343-54.
2004: Frank Altznauer; Sébastien Conus; Andrea Cavalli; Gerd Folkers; Hans-Uwe Simon
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.
The Journal of biological chemistry 2004;279(7):5947-57.
2004: Alex Straumann; Hans-Peter Spichtin; Kathleen A Bucher; Pius Heer; Hans-Uwe Simon
Eosinophilic esophagitis: red on microscopy, white on endoscopy.
Digestion 2004;70(2):109-16.
2004: Alex Straumann; Hans-Uwe Simon
The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract.
Allergy 2004;59(1):15-25.
2003: Sabine Plötz; Hans-Uwe Simon; Ulf Darsow; Dagmar Simon; Ekaterina Vassina; Shida Yousefi; Rüdiger Hein; Tim Smith; Heidrun Behrendt; Johannes Ring
Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis.
The New England journal of medicine 2003;349(24):2334-9.
2003: Alex Straumann; Hans-Peter Spichtin; Leticia Grize; Kathleen A Bucher; Christoph Beglinger; Hans-Uwe Simon
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years.
Gastroenterology 2003;125(6):1660-9.
2003: Frank Altznauer; Stephan Von Gunten; Peter Späth; Hans-Uwe Simon
Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations.
The Journal of allergy and clinical immunology 2003;112(6):1185-90.
2003: Ralf Baumann; Carmen Casaulta; Dagmar Simon; Sébastien Conus; Shida Yousefi; Hans-Uwe Simon
Macrophage migration inhibitory factor delays apoptosis in neutrophils by inhibiting the mitochondria-dependent death pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2221-30.
2003: Hans-Uwe Simon; H Seelbach; R Ehmann; M Schmitz
Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma.
Allergy 2003;58(12):1250-5.
2003: Dagmar Simon; Stephan Von Gunten; Siegfried Borelli; Lasse R Braathen; Hans-Uwe Simon
The interleukin-13 production by peripheral blood T cells from atopic dermatitis patients does not require CD2 costimulation.
International archives of allergy and immunology 2003;132(2):148-55.
2003: Zvi G Fridlender; Hans-Uwe Simon; Meir Shalit
Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism.
The American journal of the medical sciences 2003;326(2):98-101.
2003: Hans-Uwe Simon; Peter Späth
IVIG--mechanisms of action.
Allergy 2003;58(7):543-52.
2003: Shida Yousefi; Hans-Uwe Simon
SHP-1: a regulator of neutrophil apoptosis.
Seminars in immunology 2003;15(3):195-9.
2003: Hans-Uwe Simon
Neutrophil apoptosis pathways and their modifications in inflammation.
Immunological reviews 2003;193():101-10.
2003: Stefan Russmann; Hans U Iselin; Dominik Meier; Arthur Zimmermann; Hans-Uwe Simon; Pia Caduff; Jürg Reichen
Acute hepatitis associated with montelukast.
Journal of hepatology 2003;38(5):694-5.
2003: Hans-Uwe Simon; Sabine Plötz; Dagmar Simon; Ulrike Seitzer; Lasse R Braathen; Günter Menz; Alex Straumann; Reinhard Dummer; Francesca Levi-Schaffer
Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome.
European journal of immunology 2003;33(4):834-9.
2003: Alex Straumann; Livio Rossi; Hans-Uwe Simon; Pius Heer; Hans-Peter Spichtin; Christoph Beglinger
Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis?
Gastrointestinal endoscopy 2003;57(3):407-12.
2002: Francesca Levi-Schaffer; Vladislav Temkin; Hans-Uwe Simon; John-R Kettman; Johann Rudolf Frey; Ivan Lefkovits
Proteomic analysis of human eosinophil activation mediated by mast cells, granulocyte macrophage colony stimulating factor and tumor necrosis factor alpha.
Proteomics 2002;2(11):1616-26.
2002: Olivier Thomet; Hans-Uwe Simon
Petasins in the treatment of allergic diseases: results of preclinical and clinical studies.
International archives of allergy and immunology 2002;129(2):108-12.
2002: Henning Danz; Stefka Stoyanova; Olivier Thomet; Hans-Uwe Simon; Gerd Dannhardt; Holger Ulbrich; Matthias Hamburger
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.
Planta medica 2002;68(10):875-80.
2002: Aurore de Lavareille; Florence Roufosse; Peter Schmid-Grendelmeier; Anne Roumier; Liliane Schandené; Elie Cogan; Hans-Uwe Simon; Michel Goldman
High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome.
The Journal of allergy and clinical immunology 2002;110(3):476-9.
2002: Peter Schmid-Grendelmeier; Frank Altznauer; Barbra Fischer; Christian Bizer; Alex Straumann; Günter Menz; Kurt Blaser; Brunello Wüthrich; Hans-Uwe Simon
Eosinophils express functional IL-13 in eosinophilic inflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):1021-7.
2002: Olivier Thomet; Andreas Schapowal; Isabelle V W M Heinisch; Ulrich N Wiesmann; Hans-Uwe Simon
Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis.
International immunopharmacology 2002;2(7):997-1006.
2002: Hans-Uwe Simon
The neutralization of interleukin-5 as a therapeutic concept in allergic inflammation.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2002;19(1):25-8.
2002: Isabelle Daigle; Shida Yousefi; Marco COLONna; Douglas R Green; Hans-Uwe Simon
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils.
Nature medicine 2002;8(1):61-7.
2001: Alex Straumann; M Bauer; B Fischer; Kurt Blaser; Hans-Uwe Simon
Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response.
The Journal of allergy and clinical immunology 2001;108(6):954-61.
2001: Isabelle Daigle; Hans-Uwe Simon
Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosis.
International archives of allergy and immunology 2001;126(2):147-56.
2001: Axel Trautmann; F Altznauer; Mübeccel Akdis; Hans-Uwe Simon; Rainer Disch; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis.
The Journal of investigative dermatology 2001;117(4):927-34.
2001: Hans-Uwe Simon
Evidence for a pro-apoptotic function of CD137 in granulocytes.
Swiss medical weekly 2001;131(31-32):455-8.
2001: Olivier Thomet; Ulrich N Wiesmann; Kurt Blaser; Hans-Uwe Simon
Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(8):1310-20.
2001: I V Heinisch; C Bizer; W Volgger; Hans-Uwe Simon
Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders.
The Journal of allergy and clinical immunology 2001;108(1):21-8.
2001: Isabelle Daigle; Hans-Uwe Simon
Alternative functions for TRAIL receptors in eosinophils and neutrophils.
Swiss medical weekly 2001;131(17-18):231-7.
2001: Olivier Thomet; Ulrich N Wiesmann; Andreas Schapowal; C Bizer; Hans-Uwe Simon
Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus.
Biochemical pharmacology 2001;61(8):1041-7.
2001: Hans-Uwe Simon
Regulation of eosinophil and neutrophil apoptosis--similarities and differences.
Immunological reviews 2001;179():156-62.
2001: Hans-Uwe Simon; Sabine Plötz; Dagmar Simon; Reinhard Dummer; K Blaser
Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia.
International archives of allergy and immunology 2001;124(1-3):242-5.
2000: I V Heinisch; Isabelle Daigle; B Knöpfli; Hans-Uwe Simon
CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils.
European journal of immunology 2000;30(12):3441-6.
2000: Isabelle Daigle; Beate Rückert; Gabriel Schnetzler; Hans-Uwe Simon
Induction of the IL-10 gene via the fas receptor in monocytes--an anti-inflammatory mechanism in the absence of apoptosis.
European journal of immunology 2000;30(10):2991-7.
2000: Hans-Uwe Simon; M Weber; E Becker; Y Zilberman; Kurt Blaser; F Levi-Schaffer
Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4069-75.
2000: Hans-Uwe Simon
Eosinophil apoptosis--pathophysiologic and therapeutic implications.
Allergy 2000;55(10):910-5.
2000: Axel Trautmann; Mübeccel Akdis; D Kleemann; F Altznauer; Hans-Uwe Simon; T Graeve; M Noll; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis.
The Journal of clinical investigation 2000;106(1):25-35.
2000: S Gratzl; A Palca; M Schmitz; Hans-Uwe Simon
Treatment with IFN-alpha in corticosteroid-unresponsive asthma.
The Journal of allergy and clinical immunology 2000;105(5):1035-6.
1999: B Dibbert; M Weber; WH Nikolaizik; P Vogt; MH Schöni; Kurt Blaser; Hans-Uwe Simon
Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13330-5.
1999: Hans-Uwe Simon; S G Plötz; Reinhard Dummer; Kurt Blaser
Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia.
The New England journal of medicine 1999;341(15):1112-20.
1999: C Hautmann; S Gratzl; D Simon; B Sigusch; F O Nestle; Hans-Uwe Simon
[Cytokine-producing lymphoma T cells in the skin and peripheral blood associated with atopy and hypereosinophilia].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1999;50(10):743-7.
1999: Cezmi A. Akdis; Mübeccel Akdis; D Simon; B Dibbert; M Weber; S Gratzl; O Kreyden; Rainer Disch; Brunello Wüthrich; Kurt Blaser; Hans-Uwe Simon
T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis.
The Journal of investigative dermatology 1999;113(4):628-34.
1999: Hans-Uwe Simon; K Blaser
[Immunologic basis of bronchial asthma].
Der Internist 1999;40(8):849-54.
1999: Mübeccel Akdis; Hans-Uwe Simon; L Weigl; O Kreyden; Kurt Blaser; Cezmi A. Akdis
Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):466-75.
1999: Hans-Uwe Simon
Apoptosis in inflammatory diseases.
International archives of allergy and immunology 1999;118(2-4):261-2.
1999: Cezmi A. Akdis; Mübeccel Akdis; Hans-Uwe Simon; Kurt Blaser
Regulation of allergic inflammation by skin-homing T cells in allergic eczema.
International archives of allergy and immunology 1999;118(2-4):140-4.
1999: Hans-Uwe Simon
New insights into the pathogenesis of asthma.
Current problems in dermatology 1999;28():124-8.
1999: Cezmi A. Akdis; Mübeccel Akdis; D Simon; B Dibbert; M Weber; S Gratzl; O Kreyden; Rainer Disch; Brunello Wüthrich; Kurt Blaser; Hans-Uwe Simon
Role of T cells and cytokines in the intrinsic form of atopic dermatitis.
Current problems in dermatology 1999;28():37-44.
1998: S G Plötz; B Dibbert; D Abeck; Johannes Ring; Hans-Uwe Simon
Bcl-2 expression by eosinophils in a patient with hypereosinophilia.
The Journal of allergy and clinical immunology 1998;102(6 Pt 1):1037-40.
1998: Bernd W Sigusch; Gottwalt Klinger; Eike Glockmann; Hans-Uwe Simon
Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes.
Journal of periodontology 1998;69(10):1098-104.
1998: B Dibbert; Isabelle Daigle; D Braun; C Schranz; M Weber; Kurt Blaser; Uwe Zangemeister-Wittke; A N Akbar; Hans-Uwe Simon
Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5.
Blood 1998;92(3):778-83.
1998: Hans-Uwe Simon; Shida Yousefi; B Dibbert; Holger Hebestreit; M Weber; Donald R Branch; Kurt Blaser; F Levi-Schaffer; G P Anderson
Role for tyrosine phosphorylation and Lyn tyrosine kinase in fas receptor-mediated apoptosis in eosinophils.
Blood 1998;92(2):547-57.
1998: B Dibbert; Isabelle Daigle; D Braun; C Schranz; M Weber; Kurt Blaser; Uwe Zangemeister-Wittke; A N Akbar; Hans-Uwe Simon
[Role of Bcl-xL in cytokine-induced delay of eosinophilia apoptosis].
Pneumologie (Stuttgart, Germany) 1998;52(4):186-7.
1998: Holger Hebestreit; B Dibbert; I Balatti; D Braun; Andreas Schapowal; Kurt Blaser; Hans-Uwe Simon
Disruption of fas receptor signaling by nitric oxide in eosinophils.
The Journal of experimental medicine 1998;187(3):415-25.
1997: Hans-Uwe Simon; Shida Yousefi; B Dibbert; F Levi-Schaffer; Kurt Blaser
Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils.
European journal of immunology 1997;27(12):3536-9.
1997: Hans-Uwe Simon
[Significance of delayed eosinophilic apoptosis in chronic allergic inflammations].
Schweizerische medizinische Wochenschrift 1997;127(42):1743-7.
1997: A Faith; Cezmi A. Akdis; Mübeccel Akdis; Hans-Uwe Simon; Kurt Blaser
Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):53-60.
1997: Hans-Uwe Simon
Molecular mechanisms of defective eosinophil apoptosis in diseases associated with eosinophilia.
International archives of allergy and immunology 1997;113(1-3):206-8.
1997: B Dibbert; Hans-Uwe Simon
[The molecular mechanism of apoptosis. Report of the 4th European Conference on Apoptosis].
Deutsche medizinische Wochenschrift (1946) 1997;122(16):523-6.
1997: Hans-Uwe Simon; Shida Yousefi; C Schranz; Andreas Schapowal; C Bachert; Kurt Blaser
Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3902-8.
1997: A G Oehling; Cezmi A. Akdis; Andreas Schapowal; Kurt Blaser; M Schmitz; Hans-Uwe Simon
Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma.
Allergy 1997;52(2):144-54.
1997: Shida Yousefi; Kurt Blaser; Hans-Uwe Simon
Activation of signaling pathways and prevention of apoptosis by cytokines in eosinophils.
International archives of allergy and immunology 1997;112(1):9-12.
1996: Hans-Uwe Simon
[Dysregulated apoptosis in chronic eosinophilic diseases--new therapeutic strategies for allergies and bronchial asthma].
Pneumologie (Stuttgart, Germany) 1996;50(11):790-6.
1996: Shida Yousefi; B Dibbert; Kurt Blaser; Hans-Uwe Simon
Educational Corner: Inhibition of eosinophil apoptosis in chronic allergic disease.
Cell death and differentiation 1996;3(4):443.
1996: Hans-Uwe Simon
Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation.
Cell death and differentiation 1996;3(4):349-56.
1996: Holger Hebestreit; Shida Yousefi; I Balatti; M Weber; Reto Crameri; D Simon; K Hartung; Andreas Schapowal; Kurt Blaser; Hans-Uwe Simon
Expression and function of the Fas receptor on human blood and tissue eosinophils.
European journal of immunology 1996;26(8):1775-80.
1996: Gerd Wallukat; Hans-Uwe Simon; WD Müller; I Wolf
Functional antagonism by a monoclonal antibody to digoxin in a test system of cultured rat heart myocytes.
Molecular and cellular biochemistry 1996;160-161():117-20.
1996: Michael Roth; M Nauck; Shida Yousefi; Michael Tamm; Kurt Blaser; André P Perruchoud; Hans-Uwe Simon
Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor.
The Journal of experimental medicine 1996;184(1):191-201.
1996: Shida Yousefi; D C Hoessli; Kurt Blaser; G B Mills; Hans-Uwe Simon
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.
The Journal of experimental medicine 1996;183(4):1407-14.
1996: Hans-Uwe Simon; Shida Yousefi; C C Dommann-Scherrer; Dieter R Zimmermann; S Bauer; J Barandun; Kurt Blaser
Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.
The Journal of experimental medicine 1996;183(3):1071-82.
1996: S Bauer; N Schaub; C C Dommann-Scherrer; Dieter R Zimmermann; Hans-Uwe Simon; W Wegmann
Long-term outcome of idiopathic hypereosinophilic syndrome--transition to eosinophilic gastroenteritis and clonal expansion of T-cells.
European journal of gastroenterology & hepatology 1996;8(2):181-5.
1995: Hans-Uwe Simon; K Blaser
[Interdisciplinary aspects of pneumology. Report on the 23rd Ludwig-Heilmeyer Symposium of the Society for Advances in Internal Medicine].
Deutsche medizinische Wochenschrift (1946) 1995;120(20):737-9.
1995: Shida Yousefi; Stefanie Hemmann; M Weber; C Hölzer; K Hartung; Kurt Blaser; Hans-Uwe Simon
IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5481-90.
1995: Hans-Uwe Simon; Shida Yousefi; Kurt Blaser
Tyrosine phosphorylation regulates activation and inhibition of apoptosis in human eosinophils and neutrophils.
International archives of allergy and immunology 1995;107(1-3):338-9.
1995: Hans-Uwe Simon; Shida Yousefi; M Weber; D Simon; C Hölzer; K Hartung; Kurt Blaser
Human peripheral blood eosinophils express and release interleukin-8.
International archives of allergy and immunology 1995;107(1-3):124-6.
1994: Shida Yousefi; D R Green; Kurt Blaser; Hans-Uwe Simon
Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10868-72.
1994: Hans-Uwe Simon; P W Tsao; K A Siminovitch; G B Mills; Kurt Blaser
Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):364-77.
1994: Hans-Uwe Simon; M Grotzer; WH Nikolaizik; Kurt Blaser; MH Schöni
High altitude climate therapy reduces peripheral blood T lymphocyte activation, eosinophilia, and bronchial obstruction in children with house-dust mite allergic asthma.
Pediatric pulmonology 1994;17(5):304-11.
1992: Hans-Uwe Simon; H Kraul; R Schäfer; U Kilian; Annemarie Hoffmann
Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine.
Die Pharmazie 1992;47(1):49-50.
1992: R Friedrich; Hans-Uwe Simon; W A Müller; F J Sych
Ocular toxoplasmosis: the role of cellular immune defense in the development of recurrences. Results from animal experiments.
German journal of ophthalmology 1992;1(1):54-7.
1991: Hans-Uwe Simon; C Piesch; J Furkert; H Schubert; Gerhard Schlenvoigt
[Determination of Berlopentin in human plasma using an enzyme immunoassay].
Die Pharmazie 1991;46(2):139-40.
1990: Hans-Uwe Simon; K Forner; A Büttner; D Haroske; K H Vogt
[The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides].
Die Pharmazie 1990;45(12):917-9.
1990: Hans-Uwe Simon; G Metzner; W E Vogt; C Piesch; K Forner; Gerhard Schlenvoigt; H Storz; D Haroske; L Jäger
Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever.
Allergologia et immunopathologia 1990;18(3):155-60.
1990: Hans-Uwe Simon; G Metzner; E Keil; C Piesch; Gerhard Schlenvoigt; H Storz; L Jäger
[Disease-specific and non-specific seasonal parameter changes in hayfever patients].
Allergie und Immunologie 1990;36(1):3-10.
1990: Hans-Uwe Simon; B Reipert; D Haroske; K Forner; H Storz
[Age-dependent sensitivity of human lymphocytes to the immunomodulating effect of bovine and human diacetyl splenopentin].
Allergie und Immunologie 1990;36(4):351-8.
1990: Hans-Uwe Simon; W Hubl; WD Müller; I Wolf; Gerhard Schlenvoigt; L Jäger
[Production and characterization of a high affinity monoclonal antibody with digoxin and digitoxin specificity].
Allergie und Immunologie 1990;36(4):343-50.
1990: Hans-Uwe Simon; G Metzner; E Keil; K Forner; W E Vogt; L Jäger
Phase-I study of diacetyl-splenopentin (BCH 069).
Allergie und Immunologie 1990;36(4):245-51.
1990: Hans-Uwe Simon; H Roth; K Forner; D Haroske
[Immunological status of patients with recurrent herpes simplex infections. In vitro effect of thymopoietin and splenin-derived and partially modified peptides on peripheral blood lymphocytes in comparison to a thymus extract].
Allergie und Immunologie 1990;36(2):111-8.