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Michel Simon

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Laurence Pellerin; Elke Rodriguez; Anne-Marie Schmitt; Guy Serre; Stéfana Balica; Britta Hansmann; Julie Henry; Chiung-Yueh HSU; Catherine Jean-Decoster; Marie-Claire Méchin; Carle Paul; Stefan Weindinger; Michel Simon
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
Sophie Garrido Lagarrigue; C Lauze; Nicolas Meyer; Emmanuel Questel; Anne-Marie Schmitt; Guy Serre; Michel Simon; Jerome George; Jean-Michel Lagarde; Carle Paul
In vivo quantification of epidermis pigmentation and dermis papilla density with reflectance confocal microscopy: variations with age and skin phototype.
J Mazereeuw-Hautier; Guy Serre; Michel Simon; E A Leclerc; Nathalie Jonca
A novel mutation in CDSN causes peeling skin disease in a patient from Morocco.

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All Publications

2013: Laurence Pellerin; Elke Rodriguez; Anne-Marie Schmitt; Guy Serre; Stéfana Balica; Britta Hansmann; Julie Henry; Chiung-Yueh HSU; Catherine Jean-Decoster; Marie-Claire Méchin; Carle Paul; Stefan Weindinger; Michel Simon
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
The Journal of allergy and clinical immunology 2013;131(4):1094-102.
2012: Sophie Garrido Lagarrigue; C Lauze; Nicolas Meyer; Emmanuel Questel; Anne-Marie Schmitt; Guy Serre; Michel Simon; Jerome George; Jean-Michel Lagarde; Carle Paul
In vivo quantification of epidermis pigmentation and dermis papilla density with reflectance confocal microscopy: variations with age and skin phototype.
Experimental dermatology 2012;21(4):281-6.
2011: J Mazereeuw-Hautier; Guy Serre; Michel Simon; E A Leclerc; Nathalie Jonca
A novel mutation in CDSN causes peeling skin disease in a patient from Morocco.
The British journal of dermatology 2011;165(5):1152-5.
2011: Chiung-Yueh HSU; Marie-Claire Méchin; Dany Nassar; Carle Paul; Valérie Pendaries; Anne-Aurélie Raymond; Anne-Marie Schmitt; Guy Serre; Stéfana Balica; Odile Burlet-Schiltz; Britta Hansmann; Julie Henry; Hidenari Takahara; Michel Simon
Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.
The Journal of biological chemistry 2011;286(26):23222-33.
2011: Nathalie Jonca; Cécile Caubet; Emilie A Leclerc; Marina Guerrin; Michel Simon; Guy Serre
Protease sensitivity of corneodesmosin variants encoded by the six more common CDSN haplotypes.
The Journal of investigative dermatology 2011;131(6):1381-4.
2011: Nathalie Jonca; Emilie A Leclerc; Cécile Caubet; Marina Guerrin; Michel Simon; Guy Serre
Corneodesmosomes and corneodesmosin: from the stratum corneum cohesion to the pathophysiology of genodermatoses.
European journal of dermatology : EJD 2011;21 Suppl 2():35-42.
2011: Marie-Claire Méchin; Rachida Nachat; Fanny Coudane; Véronique Adoue; Jacques Arnaud; Guy Serre; Michel Simon
[Deimination or citrullination, a post-translational modification with many physiological and pathophysiological facets].
Médecine sciences : M/S 2011;27(1):49-54.
2010: Shibo Ying; Toshio Kojima; Akira Kawada; Rachida Nachat; Guy Serre; Michel Simon; Hidenari Takahara
An intronic enhancer driven by NF-κB contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes.
The Journal of investigative dermatology 2010;130(11):2543-52.
2010: Marie-Claire Méchin; Fanny Coudane; Véronique Adoue; Jacques Arnaud; H Duplan; Marie Charveron; Anne-Marie Schmitt; Hidenari Takahara; Guy Serre; Michel Simon
Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases.
Cellular and molecular life sciences : CMLS 2010;67(9):1491-503.
2008: Véronique Adoue; Stéphane Chavanas; Fanny Coudane; Marie-Claire Méchin; Cécile Caubet; Shibo Ying; Sijun Dong; Hélène Duplan; Marie Charveron; Hidenari Takahara; Guy Serre; Michel Simon
Long-range enhancer differentially regulated by c-Jun and JunD controls peptidylarginine deiminase-3 gene in keratinocytes.
Journal of molecular biology 2008;384(5):1048-57.
2008: Anne-Aurélie Raymond; Anne Gonzalez de Peredo; Alexandre Stella; Akemi Ishida-Yamamoto; David Bouyssie; Guy Serre; Bernard Monsarrat; Michel Simon
Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion.
Molecular & cellular proteomics : MCP 2008;7(11):2151-75.
2008: Michel Simon; R Tazi-Ahnini; Nathalie Jonca; Cécile Caubet; M J Cork; Guy Serre
Alterations in the desquamation-related proteolytic cleavage of corneodesmosin and other corneodesmosomal proteins in psoriatic lesional epidermis.
The British journal of dermatology 2008;159(1):77-85.
2008: Sijun Dong; Shibo Ying; Toshio Kojima; Masakazu Shiraiwa; Akira Kawada; Marie-Claire Méchin; Véronique Adoue; Stéphane Chavanas; Guy Serre; Michel Simon; Hidenari Takahara
Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes.
The Journal of investigative dermatology 2008;128(3):549-57.
2008: Stéphane Chavanas; Véronique Adoue; Marie-Claire Méchin; Shibo Ying; Sijun Dong; Hélène Duplan; Marie Charveron; Hidenari Takahara; Guy Serre; Michel Simon
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
PloS one 2008;3(10):e3408.
2007: Céline Foulquier; Mireille Sebbag; Cyril Clavel; Sabine Chapuy-Regaud; Roula Al Badine; Marie-Claire Méchin; Christian Vincent; Rachida Nachat; Michiyuki Yamada; Hidenari Takahara; Michel Simon; Marina Guerrin; Guy Serre
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
Arthritis and rheumatism 2007;56(11):3541-53.
2007: Marie-Claire Méchin; Mireille Sebbag; J Arnaud; Rachida Nachat; Céline Foulquier; V Adoue; F Coudane; H Duplan; Anne-Marie Schmitt; Stéphane Chavanas; M Guerrin; Guy Serre; Michel Simon
Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases.
International journal of cosmetic science 2007;29(3):147-68.
2007: A-A Raymond; Marie-Claire Méchin; Rachida Nachat; Eve Toulza; R Tazi-Ahnini; Guy Serre; Michel Simon
Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed.
The British journal of dermatology 2007;156(3):420-7.
2006: Stéphane Chavanas; Marie-Claire Méchin; Rachida Nachat; Véronique Adoue; Fanny Coudane; Guy Serre; Michel Simon
Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.
Journal of dermatological science 2006;44(2):63-72.
2006: Sijun Dong; Takuya Kanno; Ayako Yamaki; Toshio Kojima; Masakazu Shiraiwa; Akira Kawada; Marie-Claire Méchin; Stéphane Chavanas; Guy Serre; Michel Simon; Hidenari Takahara
NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.
The Biochemical journal 2006;397(3):449-59.
2005: Marie-Claire Méchin; M Enji; Rachida Nachat; Stéphane Chavanas; Marie Charveron; Akemi Ishida-Yamamoto; Guy Serre; Hidenari Takahara; Michel Simon
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.
Cellular and molecular life sciences : CMLS 2005;62(17):1984-95.
2005: Rachida Nachat; Marie-Claire Méchin; Marie Charveron; Guy Serre; Jacques Constans; Michel Simon
Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages.
The Journal of investigative dermatology 2005;125(1):34-41.
2005: Sijun Dong; Toshio Kojima; Masakazu Shiraiwa; Marie-Claire Méchin; Stéphane Chavanas; Guy Serre; Michel Simon; Akira Kawada; Hidenari Takahara
Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors.
The Journal of investigative dermatology 2005;124(5):1026-33.
2005: Rachida Nachat; Marie-Claire Méchin; Hidenari Takahara; Stéphane Chavanas; Marie Charveron; Guy Serre; Michel Simon
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.
The Journal of investigative dermatology 2005;124(2):384-93.
2004: Cécile Caubet; Nathalie Jonca; Maria Brattsand; Marina Guerrin; Dominique Bernard; Rainer Schmidt; Torbjörn Egelrud; Michel Simon; Guy Serre
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7.
The Journal of investigative dermatology 2004;122(5):1235-44.
2004: Stéphane Chavanas; Marie-Claire Méchin; Hidenari Takahara; Akira Kawada; Rachida Nachat; Guy Serre; Michel Simon
Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.
Gene 2004;330():19-27.
2004: Cécile Caubet; Nathalie Jonca; Frédéric Lopez; Jean-Pierre Estève; Michel Simon; Guy Serre
Homo-oligomerization of human corneodesmosin is mediated by its N-terminal glycine loop domain.
The Journal of investigative dermatology 2004;122(3):747-54.
2004: Hélène Gallinaro; Nathalie Jonca; Lutz Langbein; Christian Vincent; Michel Simon; Guy Serre; Marina Guerrin
A 4.2 kb upstream region of the human corneodesmosin gene directs site-specific expression in hair follicles and hyperkeratotic epidermis of transgenic mice.
The Journal of investigative dermatology 2004;122(3):730-8.
2003: Etgar Levy-Nissenbaum; Regina C Betz; Moshe Frydman; Michel Simon; Hadas Lahat; Tangiz Bakhan; Boleslaw Goldman; Anette Bygum; Monika Pierick; Axel M Hillmer; Nathalie Jonca; Jaime Toribio; Roland Kruse; Georg Dewald; Sven Cichon; Christian Kubisch; Marina Guerrin; Guy Serre; Markus M Nöthen; Elon Pras
Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin.
Nature genetics 2003;34(2):151-3.
2003: Marina Guerrin; Akihito Ishigami; Marie-Claire Méchin; Rachida Nachat; Séverine Valmary; Mireille Sebbag; Michel Simon; Tatsuo Senshu; Guy Serre
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I.
The Biochemical journal 2003;370(Pt 1):167-74.
2002: Nathalie Jonca; Marina Guerrin; Krassimira Hadjiolova; Cécile Caubet; Hélène Gallinaro; Michel Simon; Guy Serre
Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties.
The Journal of biological chemistry 2002;277(7):5024-9.
2001: M Allen; Akemi Ishida-Yamamoto; J McGrath; S Davison; H Iizuka; Michel Simon; Marina Guerrin; A Hayday; R Vaughan; Guy Serre; Richard C Trembath; J Barker
Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders.
Laboratory investigation; a journal of technical methods and pathology 2001;81(7):969-76.
2001: Michel Simon; Nathalie Jonca; Marina Guerrin; Marek Haftek; D Bernard; Cécile Caubet; Torbjörn Egelrud; R Schmidt; Guy Serre
Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation.
The Journal of biological chemistry 2001;276(23):20292-9.
2001: Marina Guerrin; Christian Vincent; Michel Simon; R Tazi Ahnini; M Fort; Guy Serre
Identification of six novel polymorphisms in the human corneodesmosin gene.
Tissue antigens 2001;57(1):32-8.
2001: Michel Simon; D Bernard; AM Minondo; C Camus; F Fiat; P Corcuff; R Schmidt; Guy Serre
Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin.
The Journal of investigative dermatology 2001;116(1):23-30.
2001: M Miédougé; A Devys; Michel Simon; P Rouzaud; G Salama; J Reyre; Marie-Christine Pujazon; Pierre Carles; Guy Serre
High levels of cytokeratin 19 fragments but no evidence of cytokeratins 1, 2, 10/11, 14 or filaggrin in the serum of squamous cell lung carcinoma patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2001;22(1):19-26.
1999: E Girbal-Neuhauser; JJ Durieux; Michel Arnaud; Pascal Dalbon; Mireille Sebbag; Christian Vincent; Michel Simon; Tatsuo Senshu; C Masson-Bessière; Colette Jolivet-Reynaud; Michel Jolivet; Guy Serre
The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):585-94.
1998: Marina Guerrin; Michel Simon; M Montézin; Marek Haftek; Christian Vincent; Guy Serre
Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation.
The Journal of biological chemistry 1998;273(35):22640-7.
1998: Christian Vincent; Michel Simon; Mireille Sebbag; E Girbal-Neuhauser; JJ Durieux; Alain Cantagrel; Bernard Fournié; Bernard Mazières; Guy Serre
Immunoblotting detection of autoantibodies to human epidermis filaggrin: a new diagnostic test for rheumatoid arthritis.
The Journal of rheumatology 1998;25(5):838-46.
1997: Michel Simon; M Montézin; Marina Guerrin; JJ Durieux; Guy Serre
Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes.
The Journal of biological chemistry 1997;272(50):31770-6.
1997: M Montézin; Michel Simon; Marina Guerrin; Guy Serre
Corneodesmosin, a corneodesmosome-specific basic protein, is expressed in the cornified epithelia of the pig, guinea pig, rat, and mouse.
Experimental cell research 1997;231(1):132-40.
1997: E Girbal-Neuhauser; M Montézin; F Croute; Mireille Sebbag; Michel Simon; JJ Durieux; Guy Serre
Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies.
Molecular medicine (Cambridge, Mass.) 1997;3(2):145-56.
1996: Marek Haftek; F Cambazard; D Dhouailly; A Réano; Michel Simon; A Lachaux; Guy Serre; Alain Claudy; Daniel Schmitt
A longitudinal study of a harlequin infant presenting clinically as non-bullous congenital ichthyosiform erythroderma.
The British journal of dermatology 1996;135(3):448-53.
1996: Michel Simon; Marek Haftek; Mireille Sebbag; M Montézin; E Girbal-Neuhauser; Daniel Schmitt; Guy Serre
Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis.
The Biochemical journal 1996;317 ( Pt 1)():173-7.
1995: Michel Simon; Mireille Sebbag; Marek Haftek; Christian Vincent; E Girbal-Neuhauser; J Rakotoarivony; G Sommé; Daniel Schmitt; Guy Serre
Monoclonal antibodies to human epidermal filaggrin, some not recognizing profilaggrin.
The Journal of investigative dermatology 1995;105(3):432-7.
1995: Mireille Sebbag; Michel Simon; Christian Vincent; C Masson-Bessière; E Girbal; JJ Durieux; Guy Serre
The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.
The Journal of clinical investigation 1995;95(6):2672-9.
1995: Michel Simon; Christian Vincent; Marek Haftek; E Girbal; Mireille Sebbag; V Gomès-Daudrix; Guy Serre
The rheumatoid arthritis-associated autoantibodies to filaggrin label the fibrous matrix of the cornified cells but not the profilaggrin-containing keratohyalin granules in human epidermis.
Clinical and experimental immunology 1995;100(1):90-8.
1994: V Gomès-Daudrix; Mireille Sebbag; E Girbal; Christian Vincent; Michel Simon; J Rakotoarivony; M Abbal; Bernard Fournié; Guy Serre
Immunoblotting detection of so-called 'antikeratin antibodies': a new assay for the diagnosis of rheumatoid arthritis.
Annals of the rheumatic diseases 1994;53(11):735-42.
1993: E Girbal; Mireille Sebbag; V Gomès-Daudrix; Michel Simon; Christian Vincent; Guy Serre
Characterisation of the rat oesophagus epithelium antigens defined by the so-called 'antikeratin antibodies', specific for rheumatoid arthritis.
Annals of the rheumatic diseases 1993;52(10):749-57.
1993: Michel Simon; E Girbal; Mireille Sebbag; V Gomès-Daudrix; Christian Vincent; G Salama; Guy Serre
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.
The Journal of clinical investigation 1993;92(3):1387-93.