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Melvin Simon

Research Profile

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Physiology

Signal Transduction

Chemicals & Drugs

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Ajit S Divakaruni; David A Ferrick; Robert R Henry; Alejandro P Heuck; Mattias Loviscach; William G McDonald; Susanna Petrosyan; George W Rogers; Melvin I Simon; Estelle A Wall; Sandra E Wiley; Nagendra Yadava; Alexander Andreyev; Theodore P Ciaraldi; Jerry R Colca; Anne N Murphy
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
Xiaoqing Gan; Tohru Kozasa; Stefan Offermanns; Melvin I Simon; Eeva Sommer; Srinivasa Srinivasula; Chen Wang; Jiyong Wang; Dario Alessi; Dianqing Wu
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Sang-Kyou Han; Melvin I Simon
Intracellular signaling and the origins of the sensations of itch and pain.

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All Publications

2013: Ajit S Divakaruni; David A Ferrick; Robert R Henry; Alejandro P Heuck; Mattias Loviscach; William G McDonald; Susanna Petrosyan; George W Rogers; Melvin I Simon; Estelle A Wall; Sandra E Wiley; Nagendra Yadava; Alexander Andreyev; Theodore P Ciaraldi; Jerry R Colca; Anne N Murphy
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5422-7.
2012: Xiaoqing Gan; Tohru Kozasa; Stefan Offermanns; Melvin I Simon; Eeva Sommer; Srinivasa Srinivasula; Chen Wang; Jiyong Wang; Dario Alessi; Dianqing Wu
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Nature cell biology 2012;14(7):686-96.
2011: Sang-Kyou Han; Melvin I Simon
Intracellular signaling and the origins of the sensations of itch and pain.
Science signaling 2011;4(187):pe38.
2011: Sang-Kyou Han; Melvin I Simon
Intracellular signaling and the origins of the sensations of itch and pain.
Science signaling 2011;4(185):pe38.
2011: Se-Jeong Kim; Goon Ho Park; Donghoon Kim; Jaekwang Lee; Hyejung Min; Estelle Wall; C Justin Lee; Melvin I Simon; Sung Joong Lee; Sang-Kyou Han
Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3371-6.
2011: Robert A Rebres; Tamara I A Roach; Iain D C Fraser; Finly Philip; Christina Moon; Keng-Mean Lin; Jamie Liu; Leah Santat; Lucas Cheadle; Elliott M Ross; Melvin I Simon; William Seaman
Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.
The Journal of biological chemistry 2011;286(2):942-51.
2010: Xiaoyan Robert Bao; Iain D C Fraser; Estelle A Wall; Stephen R Quake; Melvin I Simon
Variability in G-protein-coupled signaling studied with microfluidic devices.
Biophysical journal 2010;99(8):2414-22.
2010: Donghoon Kim; Byunghyun You; Eun-Kyeong Jo; Sang-Kyou Han; Melvin I Simon; Sung Joong Lee
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14851-6.
2009: Noritaka Imamachi; Goon Ho Park; Hyosang Lee; David J Anderson; Melvin I Simon; Allan I Basbaum; Sang-Kyou Han
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11330-5.
2009: Estelle A Wall; Joelle R Zavzavadjian; Mi Sook Chang; Baljinder Randhawa; Xiaocui Zhu; Robert C Hsueh; Jamie Liu; Adrienne Driver; Xiaoyan Robert Bao; Paul C Sternweis; Melvin I Simon; Iain D C Fraser
Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.
Science signaling 2009;2(75):ra28.
2009: Robert C Hsueh; Madhusudan Natarajan; Iain Fraser; Blake Pond; Jamie Liu; Susanne Mumby; Heping Han; Lily I Jiang; Melvin I Simon; Ronald Taussig; Paul C Sternweis
Deciphering signaling outcomes from a system of complex networks.
Science signaling 2009;2(71):ra22.
2008: Kevin C Slep; Michele A Kercher; Thomas Wieland; Ching-Kang Chen; Melvin I Simon; Paul B Sigler
Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6243-8.
2007: Guixiu Shi; Santiago Partida-Sánchez; Ravi S Misra; Michael Tighe; Michael T Borchers; James J Lee; Melvin I Simon; Frances E Lund
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.
The Journal of experimental medicine 2007;204(11):2705-18.
2007: Ralph S Pero; Michael T Borchers; Karsten Spicher; Sergei I Ochkur; Lyudmila Sikora; Savita P Rao; Hiam Abdala-Valencia; Katie R O'Neill; Huahao Shen; Michael P McGarry; Nancy A Lee; Joan M Cook-Mills; Pragada Sriramarao; Melvin I Simon; Lutz Birnbaumer; James J Lee
Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4371-6.
2007: Joelle R Zavzavadjian; Sam Couture; Wei Sun Park; James Whalen; Stephen Lyon; Genie Lee; Eileen Fung; Qingli Mi; Jamie Liu; Estelle Wall; Leah Santat; Kavitha Dhandapani; Christine Kivork; Adrienne Driver; Xiaocui Zhu; Mi Sook Chang; Baljinder Randhawa; Elizabeth Gehrig; Heather Bryan; Mary Verghese; Andreia Maer; Brian Saunders; Yuhong Ning; Shankar Subramaniam; Tobias Meyer; Melvin I Simon; Nancy O'Rourke; Grischa Chandy; Iain D C Fraser
The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.
Molecular & cellular proteomics : MCP 2007;6(3):413-24.
2007: Xiaocui Zhu; Leah Santat; Mi Sook Chang; Jamie Liu; Joelle R Zavzavadjian; Estelle Wall; Christine Kivork; Melvin I Simon; Iain D C Fraser
A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs.
BMC molecular biology 2007;8():98.
2006: Sang-Kyou Han; Valeria Mancino; Melvin I Simon
Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons.
Neuron 2006;52(4):691-703.
2006: Xiaocui Zhu; Mi Sook Chang; Robert C Hsueh; Ron Taussig; Kelly D Smith; Melvin I Simon; Sangdun Choi
Dual ligand stimulation of RAW 264.7 cells uncovers feedback mechanisms that regulate TLR-mediated gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4299-310.
2006: Kum-Joo Shin; Estelle Wall; Joelle R Zavzavadjian; Leah Santat; Jamie Liu; Jong-Ik Hwang; Robert Rebres; Tamara Roach; William Seaman; Melvin I Simon; Iain D C Fraser
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13759-64.
2006: Priya Kunapuli; Seungtaek Lee; Wei Zheng; Melissa Alberts; Oleg Kornienko; Rebecca Mull; Anthony Kreamer; Jong-Ik Hwang; Melvin I Simon; Berta Strulovici
Identification of small molecule antagonists of the human mas-related gene-X1 receptor.
Analytical biochemistry 2006;351(1):50-61.
2006: Marie E Burns; Ana Mendez; Ching-Kang Chen; Aileen Almuete; Nidia Quillinan; Melvin I Simon; Denis A Baylor; Jeannie Chen
Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(3):1036-44.
2005: Cindy M Quezada; Damon J Hamel; Cristian Gradinaru; Alexandrine M Bilwes; Frederick W Dahlquist; Brian R Crane; Melvin I Simon
Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA.
The Journal of biological chemistry 2005;280(34):30581-5.
2005: Jong-Ik Hwang; Sangdun Choi; Iain D C Fraser; Mi Sook Chang; Melvin I Simon
Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9493-8.
2005: Abraham Kovoor; Petra Seyffarth; Jana Ebert; Sami Barghshoon; Ching-Kang Chen; Sigrid Schwarz; Jeffrey D Axelrod; Benjamin N R Cheyette; Melvin I Simon; Henry A Lester; Johannes Schwarz
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(8):2157-65.
2004: Xiaocui Zhu; Rebecca Hart; Mi Sook Chang; Jong-Woo Kim; Sun Young Lee; Yun Anna Cao; Dennis Mock; Eugene Ke; Brian Saunders; Angela Alexander; Joella Grossoehme; Keng-Mean Lin; Zhen Yan; Robert C Hsueh; Jamie Lee; Richard Scheuermann; David A Fruman; William Seaman; Shankar Subramaniam; Paul Sternweis; Melvin I Simon; Sangdun Choi
Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7141-9.
2004: Cindy M Quezada; Cristian Gradinaru; Melvin I Simon; Alexandrine M Bilwes; Brian R Crane
Helical shifts generate two distinct conformers in the atomic resolution structure of the CheA phosphotransferase domain from Thermotoga maritima.
Journal of molecular biology 2004;341(5):1283-94.
2004: Sang-Youn Park; Bryan D Beel; Melvin I Simon; Alexandrine M Bilwes; Brian R Crane
In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11646-51.
2004: Clint L Makino; R L Dodd; J Chen; Marie E Burns; A Roca; Melvin I Simon; Denis A Baylor
Recoverin regulates light-dependent phosphodiesterase activity in retinal rods.
The Journal of general physiology 2004;123(6):729-41.
2004: Jong-Ik Hwang; Iain D C Fraser; Sangdun Choi; Xiao-Feng Qin; Melvin I Simon
Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):488-93.
2004: A Roca; K-J Shin; X Liu; Melvin I Simon; Jeannie Chen
Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration.
Neuroscience 2004;129(3):779-90.
2003: Carol Bastiani; Shahla Gharib; Melvin I Simon; Paul W Sternberg
Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.
Genetics 2003;165(4):1805-22.
2003: Claudia M Krispel; Ching-Kang Chen; Melvin I Simon; Marie E Burns
Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction.
The Journal of general physiology 2003;122(6):703-12.
2003: Maria Julia Marinissen; Joan-Marc Servitja; Stefan Offermanns; Melvin I Simon; J Silvio Gutkind
Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.
The Journal of biological chemistry 2003;278(47):46814-25.
2003: Alexandra Moers; Bernhard Nieswandt; Steffen Massberg; Nina Wettschureck; Sabine Grüner; Ildiko Konrad; Valerie Schulte; Barsom Aktas; Marie-Pierre Gratacap; Melvin I Simon; Meinrad Gawaz; Stefan Offermanns
G13 is an essential mediator of platelet activation in hemostasis and thrombosis.
Nature medicine 2003;9(11):1418-22.
2003: Tau-Mu Yi; Hiroaki Kitano; Melvin I Simon
A quantitative characterization of the yeast heterotrimeric G protein cycle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10764-9.
2003: Claudia M Krispel; Ching-Kang Chen; Melvin I Simon; Marie E Burns
Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(18):6965-71.
2003: Michael T Borchers; Travis L Biechele; J Paul Justice; Tracy Ansay; Stephania A Cormier; Valeria Mancino; Thomas Wilkie; Melvin I Simon; Nancy A Lee; James J Lee
Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L114-20.
2003: Zia Rahman; Johannes Schwarz; Stephen J Gold; Venetia Zachariou; Marc N Wein; Kwang Ho Choi; Abraham Kovoor; Ching-Kang Chen; Ralph J DiLeone; Sigrid C Schwarz; Dana E Selley; Laura J Sim-Selley; Michel Barrot; Robert R Luedtke; David W Self; Rachael L Neve; Henry A Lester; Melvin I Simon; Eric J Nestler
RGS9 modulates dopamine signaling in the basal ganglia.
Neuron 2003;38(6):941-52.
2003: Ching-Kang Chen; Pamela Eversole-Cire; Haikun Zhang; Valeria Mancino; Yu-Jiun Chen; Wei He; Theodore G Wensel; Melvin I Simon
Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6604-9.
2003: Lee W Slice; Sang-Kyou Han; Melvin I Simon
Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts.
Journal of cellular physiology 2003;194(2):127-38.
2002: Sang-Kyou Han; Xinzhong Dong; Jong-Ik Hwang; Mark J Zylka; David J Anderson; Melvin I Simon
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14740-5.
2002: Masami Miura; Masahiko Watanabe; Stefan Offermanns; Melvin I Simon; Masanobu Kano
Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8379-90.
2002: Wenshan Hao; Andreas Wenzel; Martin S Obin; Ching-Kang Chen; Elliott Brill; Nataliia V Krasnoperova; Pamela Eversole-Cire; Yelena Kleyner; Allen Taylor; Melvin I Simon; Christian grimm, Prof Dr. Phil. Nat.; Charlotte E Remé; Janis Lem
Evidence for two apoptotic pathways in light-induced retinal degeneration.
Nature genetics 2002;32(2):254-60.
2002: Jennifer L Gu; Stefan Müller; Valeria Mancino; Stefan Offermanns; Melvin I Simon
Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9352-7.
2002: Pamela Eversole-Cire; Jeannie Chen; Melvin I Simon
Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2.
Investigative ophthalmology & visual science 2002;43(5):1636-44.
2002: Michael T Borchers; Paul J Justice; Tracy Ansay; Valeria Mancino; Michael P McGarry; Jeffrey Crosby; Melvin I Simon; Nancy A Lee; James J Lee
Gq signaling is required for allergen-induced pulmonary eosinophilia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3543-9.
2002: Ian J Griswold; Hongjun Zhou; Mikenzie Matison; Ron Swanson; Lawrence P McIntosh; Melvin I Simon; Frederick W Dahlquist
The solution structure and interactions of CheW from Thermotoga maritima.
Nature structural biology 2002;9(2):121-5.
2002: Sorel T Fitz-Gibbon; Heidi Ladner; Ung-Jin Kim; Karl O Stetter; Melvin I Simon; Jeffrey H Miller
Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):984-9.
2001: Sangdun Choi; W Hao; Ching-Kang Chen; Melvin I Simon
Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13096-101.
2001: Xinzhong Dong; S Han; Mark J Zylka; Melvin I Simon; David J Anderson
A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
Cell 2001;106(5):619-32.
2001: Alexandrine M Bilwes; Cindy M Quezada; Laura R Croal; Brian R Crane; Melvin I Simon
Nucleotide binding by the histidine kinase CheA.
Nature structural biology 2001;8(4):353-60.
2000: Janusz H S Kabarowski; J D Feramisco; Lu Q Le; J L Gu; Shiuh-Wen Luoh; Melvin I Simon; Owen N Witte
Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12109-14.
2000: Ana Mendez; Marie E Burns; A Roca; Janis Lem; L W Wu; Melvin I Simon; Denis A Baylor; Jeannie Chen
Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.
Neuron 2000;28(1):153-64.
2000: C Yue; Chun-Ying Ku; M Liu; Melvin I Simon; Barbara M Sanborn
Molecular mechanism of the inhibition of phospholipase C beta 3 by protein kinase C.
The Journal of biological chemistry 2000;275(39):30220-5.
2000: Pamela Eversole-Cire; F A Concepcion; Melvin I Simon; S Takayama; J C Reed; Jeannie Chen
Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death.
Investigative ophthalmology & visual science 2000;41(7):1953-61.
2000: T M Yi; Y Huang; Melvin I Simon; John Doyle
Robust perfect adaptation in bacterial chemotaxis through integral feedback control.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4649-53.
2000: Abraham Kovoor; Ching-Kang Chen; W He; Theodore G Wensel; Melvin I Simon; Henry A Lester
Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins.
The Journal of biological chemistry 2000;275(5):3397-402.
2000: Ching-Kang Chen; Marie E Burns; W He; Theodore G Wensel; Denis A Baylor; Melvin I Simon
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.
Nature 2000;403(6769):557-60.
2000: B Yu; L Gu; Melvin I Simon
Inhibition of subsets of G protein-coupled receptors by empty mutants of G protein alpha subunits in g(o), G(11), and G(16).
The Journal of biological chemistry 2000;275(1):71-6.
2000: Kouichi Hashimoto; Masahiko Watanabe; H Kurihara; Stefan Offermanns; H Jiang; Y Wu; K Jun; Hee-Sup Shin; Yoshiro Inoue; Dianqing Wu; Melvin I Simon; Masanobu Kano
Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alpha q and phospholipase C beta 4.
Progress in brain research 2000;124():31-48.
1999: Jeannie Chen; Melvin I Simon; Michael T Matthes; Douglas Yasumura; Matthew M LaVail
Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness)
Investigative ophthalmology & visual science 1999;40(12):2978-82.
1999: Ching-Kang Chen; Marie E Burns; M Spencer; Gregory A Niemi; Jeannie Chen; James B Hurley; Denis A Baylor; Melvin I Simon
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3718-22.
1999: Alexandrine M Bilwes; LA Alex; Brian R Crane; Melvin I Simon
Structure of CheA, a signal-transducing histidine kinase.
Cell 1999;96(1):131-41.
1998: Masanobu Kano; Kouichi Hashimoto; Masahiko Watanabe; H Kurihara; Stefan Offermanns; H Jiang; Y Wu; K Jun; Hee-Sup Shin; Yoshiro Inoue; Melvin I Simon; Dianqing Wu
Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15724-9.
1998: B Yu; Melvin I Simon
Interaction of the xanthine nucleotide binding Goalpha mutant with G protein-coupled receptors.
The Journal of biological chemistry 1998;273(46):30183-8.
1998: DK Satpaev; Ching-Kang Chen; A Scotti; Melvin I Simon; James B Hurley; Vladlen Z Slepak
Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase.
Biochemistry 1998;37(28):10256-62.
1998: LA Alex; C Korch; Claude P Selitrennikoff; Melvin I Simon
COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7069-73.
1997: Stefan Offermanns; K Hashimoto; M Watanabe; W Sun; H Kurihara; R F Thompson; Y Inoue; M Kano; Melvin I Simon
Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14089-94.
1997: J Xu; R L Dodd; Clint L Makino; Melvin I Simon; Denis A Baylor; Jeannie Chen
Prolonged photoresponses in transgenic mouse rods lacking arrestin.
Nature 1997;389(6650):505-9.
1997: H Althoefer; Pamela Eversole-Cire; Melvin I Simon
Constitutively active Galphaq and Galpha13 trigger apoptosis through different pathways.
The Journal of biological chemistry 1997;272(39):24380-6.
1997: S Offermanns; C F Toombs; Y H Hu; Melvin I Simon
Defective platelet activation in G alpha(q)-deficient mice.
Nature 1997;389(6647):183-6.
1997: B Yu; Vladlen Z Slepak; Melvin I Simon
Characterization of a Goalpha mutant that binds xanthine nucleotides.
The Journal of biological chemistry 1997;272(29):18015-9.
1997: Thomas Wieland; Ching-Kang Chen; Melvin I Simon
The retinal specific protein RGS-r competes with the gamma subunit of cGMP phosphodiesterase for the alpha subunit of transducin and facilitates signal termination.
The Journal of biological chemistry 1997;272(14):8853-6.
1997: Sorel T Fitz-Gibbon; A J Choi; Jeffrey H Miller; Karl O Stetter; Melvin I Simon; R Swanson; Ung-Jin Kim
A fosmid-based genomic map and identification of 474 genes of the hyperthermophilic archaeon Pyrobaculum aerophilum.
Extremophiles : life under extreme conditions 1997;1(1):36-51.
1997: Stefan Offermanns; Valeria Mancino; J P Revel; Melvin I Simon
Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency.
Science (New York, N.Y.) 1997;275(5299):533-6.