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William Simonds

Research Profile

Chemicals & Drugs

Disorders

Physiology

Anatomy

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Parathyroidectomy

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Publications

TOP 3
Allison B Weisbrod; Robert T Jensen; Steven K Libutti; Stephen J Marx; Naris Nilubol; William F Simonds; Lee S Weinstein; Electron Kebebew
Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.
Lylia Nini; Mritunjay Pandey; Leelamma M Panicker; Jian-Hua Zhang; William F Simonds
Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Sahzene Yavuz; Michael T Collins; Electron Kebebew; Steven Libutti; Naris Nilubol; Giao Q Phan; Alan T Remaley; William F Simonds; Manuel Van Deventer; Lee S Weinstein; Stephen J Marx
Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.

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All Publications

2013: Allison B Weisbrod; Robert T Jensen; Steven K Libutti; Stephen J Marx; Naris Nilubol; William F Simonds; Lee S Weinstein; Electron Kebebew
Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.
The Journal of clinical endocrinology and metabolism 2013;98(1):E109-14.
2012: Lylia Nini; Mritunjay Pandey; Leelamma M Panicker; Jian-Hua Zhang; William F Simonds
Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Endocrine 2012;42(1):214-7.
2012: Sahzene Yavuz; Michael T Collins; Electron Kebebew; Steven Libutti; Naris Nilubol; Giao Q Phan; Alan T Remaley; William F Simonds; Manuel Van Deventer; Lee S Weinstein; Stephen J Marx
Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.
The Journal of clinical endocrinology and metabolism 2012;97(6):1834-41.
2012: Naris Nilubol; Giao Q Phan; William F Simonds; Lee Weinstein; Marybeth S Hughes; Robert T Jensen; Steven Libutti; Stephen Marx; Electron Kebebew
Preoperative localizing studies for initial parathyroidectomy in MEN1 syndrome: is there any benefit?
World journal of surgery 2012;36(6):1368-74.
2012: William F Simonds; Sarah Varghese; Stephen J Marx; Lynnette K Nieman
Cushing's syndrome in multiple endocrine neoplasia type 1.
Clinical endocrinology 2012;76(3):379-86.
2012: J-H Zhang; P S Connelly; P K Dagur; L Koo; A Loshakov; M Pandey; L M Panicker; E M Seigneur; William F Simonds
The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome.
Cell death & disease 2012;3():266.
2011: Jian-Hua Zhang; Ching-Kang Chen; Weiping Chen; Lily Koo; Mritunjay Pandey; Leelamma M Panicker; Owen M Schwartz; Erica M Seigneur; William F Simonds
Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.
Journal of neurochemistry 2011;119(3):544-54.
2010: John M Sharretts; Electron Kebebew; William F Simonds
Parathyroid cancer.
Seminars in oncology 2010;37(6):580-90.
2010: John M Sharretts; William F Simonds
Clinical and molecular genetics of parathyroid neoplasms.
Best practice & research. Clinical endocrinology & metabolism 2010;24(3):491-502.
2010: Leelamma M Panicker; Jian-Hua Zhang; Pradeep K Dagur; Matthew J Gastinger; William F Simonds
Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.
Endocrine-related cancer 2010;17(2):513-24.
2010: Leelamma M Panicker; Jian-Hua Zhang; Ekaterina Posokhova; Matthew J Gastinger; Kirill Martemyanov; William F Simonds
Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.
Journal of neurochemistry 2010;113(5):1101-12.
2008: Ling Lin; Jian-Hua Zhang; Leelamma M Panicker; William F Simonds
The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17420-5.
2008: Sunita K Agarwal; William F Simonds; Stephen J Marx
The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.
Molecular cancer 2008;7():65.
2007: Atsushi Ozawa; Sunita K Agarwal; Carmen Mateo; A Lee Burns; Terri S Rice; Patricia A Kennedy; Caitlin M Quigley; William F Simonds; Lee S Weinstein; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.
The Journal of clinical endocrinology and metabolism 2007;92(5):1948-51.
2007: Ling Lin; Meggan Czapiga; Lylia Nini; Jian-Hua Zhang; William F Simonds
Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function.
Molecular cancer research : MCR 2007;5(2):183-93.
2007: Lylia Nini; Abdul A Waheed; Leelamma M Panicker; Meggan Czapiga; Jian-Hua Zhang; William F Simonds
R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
BMC biochemistry 2007;8():18.
2005: Stephen J Marx; William F Simonds
Hereditary hormone excess: genes, molecular pathways, and syndromes.
Endocrine reviews 2005;26(5):615-61.
2005: Geoffrey E Woodard; Ling Lin; Jian-Hua Zhang; Sunita K Agarwal; Stephen J Marx; William F Simonds
Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.
Oncogene 2005;24(7):1272-6.
2004: Wei Hao; Monica C Skarulis; William F Simonds; Lee S Weinstein; Sunita K Agarwal; Carmen Mateo; Laura James-Newton; Gerald R Hobbs; Fathia Gibril; Robert T Jensen; Stephen J Marx
Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.
The Journal of clinical endocrinology and metabolism 2004;89(8):3776-84.
2004: Sunita K Agarwal; A Lee Burns; Karen E Sukhodolets; Patricia A Kennedy; Victor H Obungu; Alison Burgess Hickman; Michael Mullendore; Ira Whitten; Monica C Skarulis; William F Simonds; Carmen Mateo; Judy S Crabtree; Peter C Scacheri; Youngmi Ji; Elizabeth A Novotny; Lisa Garrett-Beal; Jerrold M Ward; Steven Libutti; H Richard Alexander; aniello Cerrato; Michael J Parisi; Sonia Santa Anna-A; Brian Oliver; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
Molecular pathology of the MEN1 gene.
Annals of the New York Academy of Sciences 2004;1014():189-98.
2004: William F Simonds; Geoffrey E Woodard; Jian-Hua Zhang
Assays of nuclear localization of R7/Gbeta5 complexes.
Methods in enzymology 2004;390():210-23.
2004: William F Simonds; Christiane M Robbins; Sunita K Agarwal; Geoffrey N Hendy; John D Carpten; Stephen J Marx
Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome.
The Journal of clinical endocrinology and metabolism 2004;89(1):96-102.
2003: Lee S Weinstein; William F Simonds
HRPT2, a marker of parathyroid cancer.
The New England journal of medicine 2003;349(18):1691-2.
2003: William F Simonds
G protein-regulated signaling dysfunction in human disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2003;51(4):194-214.
2003: Alexandra M Rojkova; Geoffrey E Woodard; Tzu-Chuan Huang; Christian A Combs; Jian-Hua Zhang; William F Simonds
Ggamma subunit-selective G protein beta 5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization.
The Journal of biological chemistry 2003;278(14):12507-12.
2002: Dina M Elaraj; Alan T Remaley; William F Simonds; Monica C Skarulis; Steven Libutti; David L Bartlett; David J Venzon; Stephen J Marx; H Richard Alexander
Utility of rapid intraoperative parathyroid hormone assay to predict severe postoperative hypocalcemia after reoperation for hyperparathyroidism.
Surgery 2002;132(6):1028-33; discussion 1033-4.
2002: Stephen J Marx; William F Simonds; Sunita K Agarwal; A Lee Burns; Lee S Weinstein; Craig Cochran; Monica C Skarulis; Allen Spiegel; Steven Libutti; H Richard Alexander; Clara C Chen; Richard Chang; Settara C Chandrasekharappa; Francis S Collins
Hyperparathyroidism in hereditary syndromes: special expressions and special managements.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17 Suppl 2():N37-43.
2002: William F Simonds; Laura James-Newton; Sunita K Agarwal; Bing Yang; Monica C Skarulis; Geoffrey N Hendy; Stephen J Marx
Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36 kindreds.
Medicine 2002;81(1):1-26.
2001: Maryann Kivlen; David L Bartlett; Steven Libutti; Monica C Skarulis; Stephen J Marx; William F Simonds; Lee S Weinstein; Robert T Jensen; J Andrea McCart; Arpana M Naik; Karen Kranda; Murray F Brennan; Jeffrey A Norton; Douglas L Fraker; H Richard Alexander
Reoperation for hyperparathyroidism in multiple endocrine neoplasia type 1.
Surgery 2001;130(6):991-8.
2001: D H Schussheim; Monica C Skarulis; Sunita K Agarwal; William F Simonds; A Lee Burns; Allen Spiegel; Stephen J Marx
Multiple endocrine neoplasia type 1: new clinical and basic findings.
Trends in endocrinology and metabolism: TEM 2001;12(4):173-8.
2001: Jian-Hua Zhang; Valarie Barr; Y Mo; A M Rojkova; S Liu; William F Simonds
Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain.
The Journal of biological chemistry 2001;276(13):10284-9.
2000: R K Bommakanti; S Vinayak; William F Simonds
Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits.
The Journal of biological chemistry 2000;275(49):38870-6.
2000: D L Feingold; H Richard Alexander; Clara C Chen; Steven Libutti; Thomas Shawker; William F Simonds; Stephen J Marx; Monica C Skarulis; John L Doppman; D S Schrump; David L Bartlett
Ultrasound and sestamibi scan as the only preoperative imaging tests in reoperation for parathyroid adenomas.
Surgery 2000;128(6):1103-9;discussion 1109-10.
2000: Jian-Hua Zhang; Z Lai; William F Simonds
Differential expression of the G protein beta(5) gene: analysis of mouse brain, peripheral tissues, and cultured cell lines.
Journal of neurochemistry 2000;75(1):393-403.
2000: William F Simonds; Jian-Hua Zhang
New dimensions in G protein signalling: G beta 5 and the RGS proteins.
Pharmaceutica acta Helvetiae 2000;74(2-3):333-6.
2000: Jian-Hua Zhang; William F Simonds
Copurification of brain G-protein beta5 with RGS6 and RGS7.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(3):RC59.
1999: William F Simonds
G protein regulation of adenylate cyclase.
Trends in pharmacological sciences 1999;20(2):66-73.
1997: S Pellegrino; S Zhang; A Garritsen; William F Simonds
The coiled-coil region of the G protein beta subunit. Mutational analysis of Ggamma and effector interactions.
The Journal of biological chemistry 1997;272(40):25360-6.
1996: S Zhang; O A Coso; C Lee; J Silvio Gutkind; William F Simonds
Selective activation of effector pathways by brain-specific G protein beta5.
The Journal of biological chemistry 1996;271(52):33575-9.
1996: S Zhang; O A Coso; R Collins; J Silvio Gutkind; William F Simonds
A C-terminal mutant of the G protein beta subunit deficient in the activation of phospholipase C-beta.
The Journal of biological chemistry 1996;271(33):20208-12.
1996: O A Coso; Hidemi Teramoto; William F Simonds; J Silvio Gutkind
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.
The Journal of biological chemistry 1996;271(8):3963-6.
1996: N Xu; O Coso; D Mahadevan; A De Blasi; Paul K Goldsmith; William F Simonds; J Silvio Gutkind
The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.
Cellular and molecular neurobiology 1996;16(1):51-9.
1995: C Lee; T Murakami; William F Simonds
Identification of a discrete region of the G protein gamma subunit conferring selectivity in beta gamma complex formation.
The Journal of biological chemistry 1995;270(15):8779-84.
1994: A Garritsen; William F Simonds
Multiple domains of G protein beta confer subunit specificity in beta gamma interaction.
The Journal of biological chemistry 1994;269(39):24418-23.
1994: Piero Crespo; N Xu; William F Simonds; J Silvio Gutkind
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.
Nature 1994;369(6479):418-20.
1993: William F Simonds; H K Manji; A Garritsen; A N Lupas
G proteins and beta ARK: a new twist for the coiled coil.
Trends in biochemical sciences 1993;18(9):315-7.
1993: A Garritsen; P J van Galen; William F Simonds
The N-terminal coiled-coil domain of beta is essential for gamma association: a model for G-protein beta gamma subunit interaction.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7706-10.
1992: T Murakami; William F Simonds; Allen Spiegel
Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction.
Biochemistry 1992;31(11):2905-11.
1991: Allan Levey; C A Kitt; William F Simonds; Donald L Price; Mark R Brann
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(10):3218-26.
1991: Allen Spiegel; P S Backlund; J E Butrynski; Teresa L Z Jones; William F Simonds
The G protein connection: molecular basis of membrane association.
Trends in biochemical sciences 1991;16(9):338-41.
1991: William F Simonds; J E Butrynski; N Gautam; Cecilia G Unson; Allen Spiegel
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
The Journal of biological chemistry 1991;266(9):5363-6.
1990: P S Backlund; William F Simonds; Allen Spiegel
Carboxyl methylation and COOH-terminal processing of the brain G-protein gamma-subunit.
The Journal of biological chemistry 1990;265(26):15572-6.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.
Biochemical Society symposium 1990;56():61-9.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies against synthetic peptides as probes of G protein structure and function.
Society of General Physiologists series 1990;45():185-95.
1990: Teresa L Z Jones; William F Simonds; J J Merendino; Mark R Brann; Allen Spiegel
Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):568-72.
1989: William F Simonds; R M Collins; Allen Spiegel; Mark R Brann
Membrane attachment of recombinant G-protein alpha-subunits in excess of beta gamma subunits in a eukaryotic expression system.
Biochemical and biophysical research communications 1989;164(1):46-53.
1989: William F Simonds; Paul K Goldsmith; J Codina; Cecilia G Unson; Allen Spiegel
Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7809-13.
1989: William F Simonds; Paul K Goldsmith; C J Woodard; Cecilia G Unson; Allen Spiegel
Receptor and effector interactions of Gs. Functional studies with antibodies to the alpha s carboxyl-terminal decapeptide.
FEBS letters 1989;249(2):189-94.
1988: P Goldsmith; K Rossiter; A Carter; William F Simonds; Cecilia G Unson; R Vinitsky; Allen Spiegel
Identification of the GTP-binding protein encoded by Gi3 complementary DNA.
The Journal of biological chemistry 1988;263(14):6476-9.
1988: Allen Spiegel; A Carter; M Brann; R Collins; P Goldsmith; William F Simonds; R Vinitsky; B Eide; K Rossiter; L Weinstein
Signal transduction by guanine nucleotide-binding proteins.
Recent progress in hormone research 1988;44():337-75.