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Stoney Simons

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Rats

Anatomy

Physiology

Phenomena

Protein Binding

Concepts & Ideas

Disorders

Experimental Liver Neoplasms

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Co-Publications
Name
13
Szapary, Daniele
7
Pratt, William
6
Blackford, John
6
Harmon, Jeffrey
4
Cho, Sehyung
4
Yamamoto, Keith
4
Kaul, Sunil
3
Sarlis, Nicholas
3
Yen, Paul
3
Modarress, KJ
3
Garabedian, Michael
3
Giannoukos, G
2
Hager, Gordon
2
Anzick, Sarah
2
Murphy, Patrick

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Publications

TOP 3
Luo Min; Simons S Stoney
Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.
Ronacher Katharina; Hadley Katie; Avenant Chanel; Stubsrud Elisabeth; Simons S Stoney; Louw Ann; Hapgood Janet P
Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.
Simons S Stoney
What goes on behind closed doors: physiological versus pharmacological steroid hormone actions.

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All Publications

2009: Luo Min; Simons S Stoney
Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.
Human immunology 2009;70(10):785-9.
2009: Ronacher Katharina; Hadley Katie; Avenant Chanel; Stubsrud Elisabeth; Simons S Stoney; Louw Ann; Hapgood Janet P
Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction.
Molecular and cellular endocrinology 2009;299(2):219-31.
2008: Simons S Stoney
What goes on behind closed doors: physiological versus pharmacological steroid hormone actions.
BioEssays : news and reviews in molecular, cellular and developmental biology 2008;30(8):744-56.
2008: Tao Yong-guang; Xu Yong; Xu H Eric; Simons S Stoney
Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.
Biochemistry 2008;47(29):7648-62.
2008: Suino-Powell Kelly; Xu Yong; Zhang Chenghai; Tao Yong-Guang; Tolbert W David; Simons S Stoney; Xu H Eric
Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.
Molecular and cellular biology 2008;28(6):1915-23.
2008: Szapary Daniele; Song Liang-Nian; He Yuangzheng; Simons S Stoney
Differential modulation of glucocorticoid and progesterone receptor transactivation.
Molecular and cellular endocrinology 2008;283(1-2):114-26.
2007: Wang Dongqing; Wang Qi; Awasthi Smita; Simons S Stoney
Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors.
Biochemistry 2007;46(27):8036-49.
2007: He Yuanzheng; Simons S Stoney
STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.
Molecular and cellular biology 2007;27(4):1467-85.
2006: Kim Yuli; Sun Yunguang; Chow Carson; Pommier Yves G; Simons S Stoney
Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.
The Journal of steroid biochemistry and molecular biology 2006;100(1-3):3-17.
2006: Simons S Stoney
How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor.
Current topics in medicinal chemistry 2006;6(3):271-85.
2005: Wang Dongqing; Simons S Stoney
Corepressor binding to progesterone and glucocorticoid receptors involves the activation function-1 domain and is inhibited by molybdate.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1483-500.
2005: Cho Sehyung; Blackford John A; Simons S Stoney
Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes.
Biochemistry 2005;44(9):3547-61.
2005: Cho Sehyung; Kagan Benjamin L; Blackford John A; Szapary Daniele; Simons S Stoney
Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):290-311.
2004: Chen Jun; Blackford John A; Simons S Stoney
PCR expression mutagenesis: a high-throughput mutation assay applied to the glucocorticoid receptor ligand-binding domain.
Biochemical and biophysical research communications 2004;321(4):893-9.
2004: Wang Qi; Anzick Sarah; Richter William F; Meltzer Paul; Simons S Stoney
Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors.
The Journal of steroid biochemistry and molecular biology 2004;91(4-5):197-210.
2004: Wang Qi; Blackford John A; Song Liang-Nian; Huang Ying; Cho Sehyung; Simons S Stoney
Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.
Molecular endocrinology (Baltimore, Md.) 2004;18(6):1376-95.
2004: Chen Jun; He Yuanzheng; Simons S Stoney
Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex.
Biochemistry 2004;43(1):245-55.
2003: Anzick Sarah L; Azorsa David O; Simons S Stoney; Meltzer Paul S
Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1.
BMC cancer 2003;3():22.
2003: Murphy Patrick J M; Morishima Yoshihiro; Chen Haifeng; Galigniana Mario D; Mansfield John F; Simons S Stoney; Pratt William B
Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.
The Journal of biological chemistry 2003;278(37):34764-73.
2003: Webster Jeanette I; Tonelli Leonardo H; Moayeri Mahtab; Simons S Stoney; Leppla Stephen H; Sternberg Esther M
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5706-11.
2003: Chen Shiyou; Simons S Stoney
A second pathway for modulating glucocorticoid receptor transactivation properties.
Molecular and cellular endocrinology 2003;199(1-2):129-42.
2002: He Yuanzheng; Szapary Daniele; Simons S Stoney
Modulation of induction properties of glucocorticoid receptor-agonist and -antagonist complexes by coactivators involves binding to receptors but is independent of ability of coactivators to augment transactivation.
The Journal of biological chemistry 2002;277(51):49256-66.
2002: Kaul Sunil; Murphy Patrick J M; Chen Jun; Brown Lloyd; Pratt William B; Simons S Stoney
Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain.
The Journal of biological chemistry 2002;277(39):36223-32.
2002: Chen Jun; Kaul Sunil; Simons S Stoney
Structure/activity elements of the multifunctional protein, GMEB-1. Characterization of domains relevant for the modulation of glucocorticoid receptor transactivation properties.
The Journal of biological chemistry 2002;277(24):22053-62.
2002: Kaul Sunil; Blackford John A; Cho Sehyung; Simons S Stoney
Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors.
The Journal of biological chemistry 2002;277(15):12541-9.
2001: Song L N; Huse B; Rusconi S; Simons S S
Transactivation specificity of glucocorticoid versus progesterone receptors. Role of functionally different interactions of transcription factors with amino- and carboxyl-terminal receptor domains.
The Journal of biological chemistry 2001;276(27):24806-16.
2001: Giannoukos G; Szapary D; Smith C L; Meeker J E; Simons S S
New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties.
Molecular endocrinology (Baltimore, Md.) 2001;15(2):255-70.
2000: Chen S; Sarlis N J; Simons S S
Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription.
The Journal of biological chemistry 2000;275(39):30106-17.
2000: Kaul S; Blackford J A; Chen J; Ogryzko V V; Simons S S
Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.
Molecular endocrinology (Baltimore, Md.) 2000;14(7):1010-27.
2000: Zeng H; Plisov S Y; Simons S S
Ability of the glucocorticoid modulatory element to modify glucocorticoid receptor transactivation indicates parallel pathways for the expression of glucocorticoid modulatory element and glucocorticoid response element activities.
Molecular and cellular endocrinology 2000;162(1-2):221-34.
1999: Huang Y; Simons S S
Functional analysis of R651 mutations in the putative helix 6 of rat glucocorticoid receptors.
Molecular and cellular endocrinology 1999;158(1-2):117-30.
1999: Szapary D; Huang Y; Simons S S
Opposing effects of corepressor and coactivators in determining the dose-response curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor-regulated gene expression.
Molecular endocrinology (Baltimore, Md.) 1999;13(12):2108-21.
1999: Giannoukos G; Silverstein A M; Pratt W B; Simons S S
The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding.
The Journal of biological chemistry 1999;274(51):36527-36.
1999: Xu M; Modarress K J; Meeker J E; Simons S S
Steroid-induced conformational changes of rat glucocorticoid receptor cause altered trypsin cleavage of the putative helix 6 in the ligand binding domain.
Molecular and cellular endocrinology 1999;155(1-2):85-100.
1999: Sarlis N J; Bayly S F; Szapary D; Simons S S
Quantity of partial agonist activity for antiglucocorticoids complexed with mutant glucocorticoid receptors is constant in two different transactivation assays but not predictable from steroid structure.
The Journal of steroid biochemistry and molecular biology 1999;68(3-4):89-102.
1998: Plisov S Y; Poirot M E; Modarress K J; Cavanaugh A H; Edwards D P; Simons S S
Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity.
The Journal of steroid biochemistry and molecular biology 1998;67(3):251-66.
1998: Jackson D A; Collier C D; Oshima H; Simons S S
Modulation of TAT gene induction by glucocorticoids involves a neutralizing sequence.
The Journal of steroid biochemistry and molecular biology 1998;66(3):79-91.
1998: Zeng H; Jackson D A; Oshima H; Simons S S
Cloning and characterization of a novel binding factor (GMEB-2) of the glucocorticoid modulatory element.
The Journal of biological chemistry 1998;273(28):17756-62.
1998: Xu M; Dittmar K D; Giannoukos G; Pratt W B; Simons S S
Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the amino terminus of the hormone-binding domain.
The Journal of biological chemistry 1998;273(22):13918-24.
1997: Modarress K J; Opoku J; Xu M; Sarlis N J; Simons S S
Steroid-induced conformational changes at ends of the hormone-binding domain in the rat glucocorticoid receptor are independent of agonist versus antagonist activity.
The Journal of biological chemistry 1997;272(38):23986-94.
1996: Szapary D; Xu M; Simons S S
Induction properties of a transiently transfected glucocorticoid-responsive gene vary with glucocorticoid receptor concentration.
The Journal of biological chemistry 1996;271(48):30576-82.
1996: Xu M; Chakraborti P K; Garabedian M J; Yamamoto K R; Simons S S
Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains.
The Journal of biological chemistry 1996;271(35):21430-8.
1996: Collier C D; Oshima H; Simons S S
A negative tyrosine aminotransferase gene element that blocks glucocorticoid modulatory element-regulated modulation of glucocorticoid-induced gene expression.
Molecular endocrinology (Baltimore, Md.) 1996;10(5):463-76.
1995: Oshima H; Szapary D; Simons S S
The factor binding to the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex.
The Journal of biological chemistry 1995;270(37):21893-901.
1995: Simons S S; Pratt W B
Glucocorticoid receptor thiols and steroid-binding activity.
Methods in enzymology 1995;251():406-22.
1994: Szapary D; Barber T; Dwyer N K; Blanchette-Mackie E J; Simons S S
Microtubules are not required for glucocorticoid receptor mediated gene induction.
The Journal of steroid biochemistry and molecular biology 1994;51(3-4):143-8.
1994: Modarress K J; Cavanaugh A H; Chakraborti P K; Simons S S
Metal oxyanion stabilization of the rat glucocorticoid receptor is independent of thiols.
The Journal of biological chemistry 1994;269(41):25621-8.
1994: Cavanaugh A H; Simons S S
Factor-assisted DNA binding as a possible general mechanism for steroid receptors. Functional heterogeneity among activated receptor-steroid complexes.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):433-46.
1994: Opoku J; Simons S S
Absence of intramolecular disulfides in the structure and function of native rat glucocorticoid receptors.
The Journal of biological chemistry 1994;269(1):503-10.
1993: Oshima H; Simons S S
Sequence-selective interactions of transcription factor elements with tandem glucocorticoid-responsive elements at physiological steroid concentrations.
The Journal of biological chemistry 1993;268(36):26858-65.
1993: Miyashita Y; Miller M; Yen P M; Harmon J M; Hanover J A; Simons S S
Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport.
The Journal of steroid biochemistry and molecular biology 1993;46(3):309-20.
1993: Szapary D; Oshima H; Simons S S
A new cis-acting element involved in tissue-selective glucocorticoid inducibility of tyrosine aminotransferase gene expression.
Molecular endocrinology (Baltimore, Md.) 1993;7(8):941-52.
1993: Scherrer L C; Picard D; Massa E; Harmon J M; Simons S S; Yamamoto K R; Pratt W B
Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.
Biochemistry 1993;32(20):5381-6.
1993: Stancato L F; Hutchison K A; Chakraborti P K; Simons S S; Pratt W B
Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor.
Biochemistry 1993;32(14):3729-36.
1992: Simons S S; Oshima H; Szapary D
Modulation of the agonist activity of antisteroids by a novel cis-acting element.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):43-55.
1992: Simons S S; Oshima H; Szapary D
Higher levels of control: modulation of steroid hormone-regulated gene transcription.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):995-1002.
1992: Chakraborti P K; Garabedian M J; Yamamoto K R; Simons S S
Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.
The Journal of biological chemistry 1992;267(16):11366-73.
1992: Szapary D; Oshima H; Simons S S
Modulation of glucocorticoid induction of stably transfected tyrosine aminotransferase gene constructs involves elements up-stream of the glucocorticoid-responsive element.
Endocrinology 1992;130(6):3492-502.
1992: Oshima H; Simons S S
Modulation of glucocorticoid induction of tyrosine aminotransferase gene expression by variations in cell density.
Endocrinology 1992;130(4):2106-12.
1992: Oshima H; Simons S S
Modulation of transcription factor activity by a distant steroid modulatory element.
Molecular endocrinology (Baltimore, Md.) 1992;6(3):416-28.
1991: Chakraborti P K; Garabedian M J; Yamamoto K R; Simons S S
Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain.
The Journal of biological chemistry 1991;266(33):22075-8.
1991: Lopez S; Simons S S
Dexamethasone 21-(beta-isothiocyanatoethyl) thioether: a new affinity label for glucocorticoid receptors.
Journal of medicinal chemistry 1991;34(6):1762-7.
1991: Chakraborti P K; Simons S S
Association of heat shock protein 90 with the 16 kDa steroid binding core fragment of rat glucocorticoid receptors.
Biochemical and biophysical research communications 1991;176(3):1338-44.
1991: Yen P M; Simons S S
Evidence against posttranslational glycosylation of rat glucocorticoid receptors.
Receptor 1991;1(3):191-205.
1990: Zacharchuk C M; Mercep M; Chakraborti P K; Simons S S; Ashwell J D
Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4037-45.
1990: Sanchez E R; Hirst M; Scherrer L C; Tang H Y; Welsh M J; Harmon J M; Simons S S; Ringold G M; Pratt W B
Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90.
The Journal of biological chemistry 1990;265(33):20123-30.
1990: Chakraborti P K; Hoeck W; Groner B; Simons S S
Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor.
Endocrinology 1990;127(5):2530-9.
1990: Lopez S; Miyashita Y; Simons S S
Structurally based, selective interaction of arsenite with steroid receptors.
The Journal of biological chemistry 1990;265(27):16039-42.
1990: Simons S S; Chakraborti P K; Cavanaugh A H
Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.
The Journal of biological chemistry 1990;265(4):1938-45.
1990: Cavanaugh A H; Simons S S
Glucocorticoid receptor binding to calf thymus DNA. 2. Role of a DNA-binding activity factor in receptor heterogeneity and a multistep mechanism of receptor activation.
Biochemistry 1990;29(4):996-1002.
1990: Cavanaugh A H; Simons S S
Glucocorticoid receptor binding to calf thymus DNA. 1. Identification and characterization of a macromolecular factor involved in receptor-steroid complex binding to DNA.
Biochemistry 1990;29(4):989-96.
1989: Simons S S; Sistare F D; Chakraborti P K
Steroid binding activity is retained in a 16-kDa fragment of the steroid binding domain of rat glucocorticoid receptors.
The Journal of biological chemistry 1989;264(24):14493-7.
1989: Simons S S; Mercier L; Miller N R; Miller P A; Oshima H; Sistare F D; Thompson E B; Wasner G; Yen P M
Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells.
Cancer research 1989;49(8 Suppl):2244s-2252s.
1989: Urda L A; Yen P M; Simons S S; Harmon J M
Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):251-60.
1988: Wasner G; Oshima H; Thompson E B; Simons S S
Unlinked regulation of the sensitivity of primary glucocorticoid-inducible responses in mouse mammary tumor virus infected Fu5-5 rat hepatoma cells.
Molecular endocrinology (Baltimore, Md.) 1988;2(11):1009-17.
1988: Miller N R; Simons S S
Steroid binding to hepatoma tissue culture cell glucocorticoid receptors involves at least two sulfhydryl groups.
The Journal of biological chemistry 1988;263(29):15217-25.
1988: Simons S S; Miller P A; Wasner G; Miller N R; Mercier L
Inverse correlation between dexamethasone 21-mesylate agonist activity and sensitivity to dexamethasone for induction of tyrosine aminotransferase in rat hepatoma cells.
Journal of steroid biochemistry 1988;31(1):1-7.
1988: Miller P A; Simons S S
Comparison of glucocorticoid receptors in two rat hepatoma cell lines with different sensitivities to glucocorticoids and antiglucocorticoids.
Endocrinology 1988;122(6):2990-8.
1987: Sistare F D; Hager G L; Simons S S
Mechanism of dexamethasone 21-mesylate antiglucocorticoid action: I. Receptor-antiglucocorticoid complexes do not competitively inhibit receptor-glucocorticoid complex activation of gene transcription in vivo.
Molecular endocrinology (Baltimore, Md.) 1987;1(9):648-58.
1987: Richard-Foy H; Sistare F D; Riegel A T; Simons S S; Hager G L
Mechanism of dexamethasone 21-mesylate antiglucocorticoid action: II. Receptor-antiglucocorticoid complexes do not interact productively with mouse mammary tumor virus long terminal repeat chromatin.
Molecular endocrinology (Baltimore, Md.) 1987;1(9):659-65.
1987: Wasner G; Simons S S
Differential sensitivity of HTC and Fu5-5 cells for induction of tyrosine aminotransferase by 3',5'-cyclic adenosine monophosphate.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):109-20.
1986: Mercier L; Miller P A; Simons S S
Antiglucocorticoid steroids have increased agonist activity in those hepatoma cell lines that are more sensitive to glucocorticoids.
Journal of steroid biochemistry 1986;25(1):11-20.
1984: Harmon J M; Eisen H J; Brower S T; Simons S S; Langley C L; Thompson E B
Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorticoid receptor antibodies.
Cancer research 1984;44(10):4540-7.
1981: Thompson E B; Simons S S; Harmon J M
Deacylcortivazol, a potent glucocorticoid with unusual structure and unusual anti-leukemic cell activity.
Advances in experimental medicine and biology 1981;138():315-24.

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