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James Simpkins

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Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Lin Tang; Yi Wen; Ali Winters; Hai Yan; Darell D Bigner; Gourav Roy Choudhury; Anuja Ghorpade; Stephen T Keir; Wenjun Li; Ran Liu; Fang Yuan; Shao-Hua Yang
Reversing the warburg effect as a treatment for glioblastoma.
Wenjun Li; Song Lin; Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Ali Winters; Zhen Wu; Shuyu Hao; Kimmo J Hatanpaa; Fang Yuan; Shao-Hua Yang
Involvement of estrogen receptor β5 in the progression of glioma.
James W Simpkins; Kun Don Yi; Evelyn Perez; Timothy E Richardson; Douglas F Covey
Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy.

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2013: Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Lin Tang; Yi Wen; Ali Winters; Hai Yan; Darell D Bigner; Gourav Roy Choudhury; Anuja Ghorpade; Stephen T Keir; Wenjun Li; Ran Liu; Fang Yuan; Shao-Hua Yang
Reversing the warburg effect as a treatment for glioblastoma.
The Journal of biological chemistry 2013;288(13):9153-64.
2013: Wenjun Li; Song Lin; Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Ali Winters; Zhen Wu; Shuyu Hao; Kimmo J Hatanpaa; Fang Yuan; Shao-Hua Yang
Involvement of estrogen receptor β5 in the progression of glioma.
Brain research 2013;1503():97-107.
2013: James W Simpkins; Kun Don Yi; Evelyn Perez; Timothy E Richardson; Douglas F Covey
Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy.
Hormones and behavior 2013;63(2):278-83.
2012: Joshua W Gatson; Ming-Mei Liu; Kareem Abdelfattah; James W Simpkins; Scott Smith; Jane G Wigginton; Steven Wolf; Joseph P Minei
Estrone is neuroprotective in rats after traumatic brain injury.
Journal of neurotrauma 2012;29(12):2209-19.
2012: Everett Nixon; James W Simpkins
Neuroprotective effects of nonfeminizing estrogens in retinal photoreceptor neurons.
Investigative ophthalmology & visual science 2012;53(8):4739-47.
2012: Robert R Luedtke; Robert H Mach; Evelyn Perez; Zhude Tu; Suwanna Vangveravong; Shao-Hua Yang; Ran Liu; James W Simpkins
Neuroprotective effects of high affinity Σ1 receptor selective compounds.
Brain research 2012;1441():17-26.
2012: Marianna E Jung; Daniel B Metzger; Xiaohua Ju; James W Simpkins
Ethanol withdrawal hastens the aging of cytochrome c oxidase.
Neurobiology of aging 2012;33(3):618.e21-32.
2012: Ethan Poteet; Kyle Shufelt; James W Simpkins; Yi Wen; Ali Winters; Liang-Jun Yan; Kayla N Green; Shao-Hua Yang
Neuroprotective actions of methylene blue and its derivatives.
PloS one 2012;7(10):e48279.
2012: Timothy E Richardson; James W Simpkins
R- and S-equol have equivalent cytoprotective effects in Friedreich's ataxia.
BMC pharmacology & toxicology 2012;13():12.
2012: James W Simpkins; Meharvan Singh; Courtney Brock; Anne M Etgen
Neuroprotection and estrogen receptors.
Neuroendocrinology 2012;96(2):119-30.
2012: Timothy E Richardson; Yi Wen; Shao-Hua Yang; Amanda E Yu; James W Simpkins
Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
PloS one 2012;7(4):e34600.
2011: Marianna E Jung; Daniel B Metzger; James W Simpkins; Xiaohua Ju; Liang-Jun Yan; Yi Wen
Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase.
Neurobiology of aging 2011;32(12):2266-78.
2011: James W Simpkins; James T Stevens; James A Swenberg; Noel Weiss; David Brusick; J Charles Eldridge; Robert J Handa; Russell C Hovey; Timothy P Pastoor; Tony M Plant; Charles B Breckenridge
Atrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidence.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(2):441-59.
2011: Hien P Nguyen; Lauren Tedmon; Li Li; Jane G Wigginton; David L Maass; Joshua W Gatson; James W Simpkins; Kevin A Schug
Investigation of the temperature stability of premarin intravenous using liquid chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;55(5):1218-22.
2011: Yi Wen; Wenjun Li; Ethan C Poteet; Luokun Xie; Cong Tan; Liang-Jun Yan; Xiaohua Ju; Ran Liu; Hai Qian; Marian A Marvin; Matthew S Goldberg; Hua She; Zixu Mao; James W Simpkins; Shao-Hua Yang
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
The Journal of biological chemistry 2011;286(18):16504-15.
2011: Hien P Nguyen; Li Li; Joshua W Gatson; David L Maass; Jane G Wigginton; James W Simpkins; Kevin A Schug
Simultaneous quantification of four native estrogen hormones at trace levels in human cerebrospinal fluid using liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;54(4):830-7.
2011: Kun Don YI; Evelyn Perez; Shaohua Yang; Ran Liu; Douglas F Covey; James W Simpkins
The assessment of non-feminizing estrogens for use in neuroprotection.
Brain research 2011;1379():61-70.
2011: J W Gatson; James W Simpkins; Kun Don Yi; Ahamed Idris; J P Minei; J G Wigginton
Aromatase is increased in astrocytes in the presence of elevated pressure.
Endocrinology 2011;152(1):207-13.
2010: S N Sarkar; L T Smith; S M Logan; James W Simpkins
Estrogen-induced activation of extracellular signal-regulated kinase signaling triggers dendritic resident mRNA translation.
Neuroscience 2010;170(4):1080-5.
2010: Zhang Zhang; James W Simpkins
An okadaic acid-induced model of tauopathy and cognitive deficiency.
Brain research 2010;1359():233-46.
2010: James W Simpkins; Kun Don YI; Shao-Hua Yang; James A Dykens
Mitochondrial mechanisms of estrogen neuroprotection.
Biochimica et biophysica acta 2010;1800(10):1113-20.
2010: James W Simpkins; Brian E Wood; Brian J Balin
Alzheimer disease: the crisis is upon us.
The Journal of the American Osteopathic Association 2010;110(9 Suppl 8):Sii-2.
2010: Zhang Zhang; James W Simpkins
Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner.
Brain research 2010;1345():176-81.
2010: Hien P Nguyen; Samuel H Yang; Jane G Wigginton; James W Simpkins; Kevin A Schug
Retention behavior of estrogen metabolites on hydrophilic interaction chromatography stationary phases.
Journal of separation science 2010;33(6-7):793-802.
2010: Ran Liu; Qing Liu; Shaoqing He; James W Simpkins; Shao-Hua Yang
Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke.
The Journal of pharmacology and experimental therapeutics 2010;332(3):1006-12.
2010: Luokun Xie; Ethan C Poteet; Wenjun Li; Amanda E Scott; Ran Liu; Yi Wen; Anuja Ghorpade; James W Simpkins; Shao-Hua Yang
Modulation of polymorphonuclear neutrophil functions by astrocytes.
Journal of neuroinflammation 2010;7():53.
2009: James W Simpkins
Commentary on "Alzheimer's Disease Drug Development and the Problem of the Blood-Brain Barrier".
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(5):433-4.
2009: James W Simpkins; Kimberly Brown; Sejong Bae; Anna Ratka
Role of ethnicity in the expression of features of hot flashes.
Maturitas 2009;63(4):341-6.
2009: James W Simpkins; Kun Don YI; Shao-Hua Yang
Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.
Frontiers in neuroendocrinology 2009;30(2):93-105.
2009: Shao-Hua Yang; Saumyendra N Sarkar; Ran Liu; Evelyn J Perez; Xiaofei Wang; Yi Wen; Liang-Jun Yan; James W Simpkins
Estrogen receptor beta as a mitochondrial vulnerability factor.
The Journal of biological chemistry 2009;284(14):9540-8.
2009: Katalin Prokai-Tatrai; Laszlo Prokai; James W Simpkins; Marianna E Jung
Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress.
International journal of molecular sciences 2009;10(4):1773-87.
2009: James W Simpkins; Joshua W Gatson; Jane G Wigginton
Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Rationale and recommendations for first evaluating anti-Alzheimer's disease medications in acute brain injury patients.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(2):143-6.
2009: Marianna E Jung; Andrew M Wilson; Xiaohua Ju; Yi Wen; Daniel B Metzger; James W Simpkins
Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner.
The Journal of pharmacology and experimental therapeutics 2009;328(3):692-8.
2009: Kun Don YI; Douglas F Covey; James W Simpkins
Mechanism of okadaic acid-induced neuronal death and the effect of estrogens.
Journal of neurochemistry 2009;108(3):732-40.
2009: James W Simpkins; Xiaofei Wang; Yi Wen; Shaohua Yang; Evelyn Perez; Meharvan Singh
The potential for estrogens in preventing Alzheimer's disease and vascular dementia.
Therapeutic advances in neurological disorders 2009;2(1):31-49.
2009: Joshua W Gatson; David L Maass; James W Simpkins; Ahamed Idris; Joseph P Minei; Jane G Wigginton
Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling.
Journal of neuroinflammation 2009;6():30.
2008: Kun Don Yi; James W Simpkins
Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection.
Endocrinology 2008;149(10):5235-43.
2008: Saumyendra N Sarkar; Ren-Qi Huang; Shaun M Logan; Kun Don YI; Glenn H Dillon; James W Simpkins
Estrogens directly potentiate neuronal L-type Ca2+ channels.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15148-53.
2008: Kun Don YI; Zu Yun Cai; Douglas F Covey; James W Simpkins
Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1188-95.
2008: Katalin Prokai-Tatrai; Pal Perjesi; Nilka M Rivera-Portalatin; James W Simpkins; Laszlo Prokai
Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative.
Steroids 2008;73(3):280-8.
2008: James W Simpkins; James A Dykens
Mitochondrial mechanisms of estrogen neuroprotection.
Brain research reviews 2008;57(2):421-30.
2008: Marianna E Jung; Liang-Jun Yan; Michael J Forster; James W Simpkins
Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner.
Journal of bioenergetics and biomembranes 2008;40(1):35-44.
2008: James W Simpkins; Meharvan Singh
More than a decade of estrogen neuroprotection.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(1 Suppl 1):S131-6.
2008: Meharvan Singh; Nathalie Sumien; Cheryl Kyser; James W Simpkins
Estrogens and progesterone as neuroprotectants: what animal models teach us.
Frontiers in bioscience : a journal and virtual library 2008;13():1083-9.
2008: Arti B Sharma; Matthew Barlow; Shao-Hua Yang; James W Simpkins; Robert T Mallet
Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation.
Resuscitation 2008;76(1):108-19.
2007: John A Schetz; Evelyn Perez; Ran Liu; Shiuhwei Chen; Ivan Lee; James W Simpkins
A prototypical Sigma-1 receptor antagonist protects against brain ischemia.
Brain research 2007;1181():1-9.
2007: Marianna E Jung; Rajnee Agarwal; James W Simpkins
Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner.
Neuroscience letters 2007;416(2):160-4.
2007: Laszlo Prokai; James W Simpkins
Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds.
Pharmacology & therapeutics 2007;114(1):1-12.
2007: Yi Wen; Shao-Hua Yang; Ran Liu; Evelyn J Perez; Anne-Marie Brun-Zinkernagel; Peter Koulen; James W Simpkins
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats.
Biochimica et biophysica acta 2007;1772(4):473-83.
2007: Ran Liu; Xiaofei Wang; Qing Liu; Shao-Hua Yang; James W Simpkins
Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia.
Neuroscience letters 2007;415(3):237-41.
2006: Marianna E Jung; Andrew M Wilson; James W Simpkins
A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells.
The Journal of pharmacology and experimental therapeutics 2006;319(2):543-50.
2006: Shao-Hua Yang; Laszlo Prokai; James W Simpkins
Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria".
Biochemical and biophysical research communications 2006;345(3):917-8.
2006: Xiaofei Wang; James A Dykens; Evelyn Perez; Ran Liu; Shaohua Yang; Douglas F Covey; James W Simpkins
Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells.
Molecular pharmacology 2006;70(1):395-404.
2006: Meharvan Singh; James A Dykens; James W Simpkins
Novel mechanisms for estrogen-induced neuroprotection.
Experimental biology and medicine (Maywood, N.J.) 2006;231(5):514-21.
2006: Anna Ratka; Vanessa Miller; Kimberly Brown; Atul Raut; Daisha Cipher; Blazej Meczekalski; James W Simpkins
Menopausal Vasomotor Symptoms (MVS) survey for assessment of hot flashes.
Journal of women's health (2002) 2006;15(1):77-89.
2005: Marianna E Jung; David G Watson; James W Simpkins
Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line.
Journal of neurochemistry 2005;95(3):745-55.
2005: Ran Liu; Yi Wen; Evelyn Perez; Xiaofei Wang; Arthur L Day; James W Simpkins; Shao-Hua Yang
17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats.
Brain research 2005;1060(1-2):55-61.
2005: Mridula Rewal; Yi Wen; Andrew Wilson; James W Simpkins; Marianna E Jung
Role of parvalbumin in estrogen protection from ethanol withdrawal syndrome.
Alcoholism, clinical and experimental research 2005;29(10):1837-44.
2005: Yi Wen; Shaohua Yang; Ran Liu; James W Simpkins
Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats.
FEBS letters 2005;579(21):4591-9.
2005: Kun Don YI; Jaegwon Chung; Priscilla Pang; James W Simpkins
Role of protein phosphatases in estrogen-mediated neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(31):7191-8.
2005: James W Simpkins; Yi Wen; Evelyn Perez; Shaohua Yang; Xiaofei Wang
Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology.
Annals of the New York Academy of Sciences 2005;1052():233-42.
2005: Marianna E Jung; Stephanie Jacobs; Mridula Rewal; Andrew Wilson; James W Simpkins
Estradiol protects against alteration of protein kinase C(epsilon) in a binge model of ethanol dependence and withdrawal.
European journal of pharmacology 2005;515(1-3):62-72.
2005: D Maneesh Kumar; Evelyn Perez; Zu Yun Cai; Paul Aoun; Anne-Marie Brun-Zinkernagel; Douglas F Covey; James W Simpkins; Neeraj Agarwal
Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity.
Free radical biology & medicine 2005;38(9):1152-63.
2005: Shao-Hua Yang; Ran Liu; Evelyn J Perez; Xiaofei Wang; James W Simpkins
Estrogens as protectants of the neurovascular unit against ischemic stroke.
Current drug targets. CNS and neurological disorders 2005;4(2):169-77.
2005: Mridula Rewal; Yi Wen; James W Simpkins; Marianna E Jung
Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens.
Neuroscience letters 2005;377(1):44-8.
2005: Evelyn Perez; Ran Liu; Shao-Hua Yang; Zu Yun Cai; Douglas F Covey; James W Simpkins
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo.
Brain research 2005;1038(2):216-22.
2005: Shao-Hua Yang; Ran Liu; Yi Wen; Evelyn Perez; Jason Cutright; Anne-Marie Brun-Zinkernagel; Meharvan Singh; Arthur L Day; James W Simpkins
Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats.
Journal of neurobiology 2005;62(3):341-51.
2005: James W Simpkins; Jian Wang; Xiaofei Wang; Evelyn Perez; Laszlo Prokai; James A Dykens
Mitochondria play a central role in estrogen-induced neuroprotection.
Current drug targets. CNS and neurological disorders 2005;4(1):69-83.
2005: James W Simpkins; S-H Yang; Y Wen; Meharvan Singh
Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies.
Cellular and molecular life sciences : CMLS 2005;62(3):271-80.
2005: Marianna E Jung; Michael B Gatch; James W Simpkins
Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanisms.
Experimental biology and medicine (Maywood, N.J.) 2005;230(1):8-22.
2004: Mridula Rewal; Marianna E Jung; James W Simpkins
Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats.
Alcoholism, clinical and experimental research 2004;28(12):1907-15.
2004: Marianna E Jung; Mridula Rewal; Evelyn Perez; Yi Wen; James W Simpkins
Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats.
Pharmacology, biochemistry, and behavior 2004;79(3):573-86.
2004: James W Simpkins; Shao-Hua Yang; Ran Liu; Evelyn Perez; Zu Yun Cai; Douglas F Covey; Pattie Green
Estrogen-like compounds for ischemic neuroprotection.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2648-51.
2004: Yi Wen; Shaohua Yang; Ran Liu; James W Simpkins
Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein.
Brain research 2004;1022(1-2):30-8.
2004: Yi Wen; Evelyn J Perez; Pattie Green; Saumyendra N Sarkar; James W Simpkins
nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells.
Neuroreport 2004;15(9):1515-8.
2004: Yi Wen; Otuonye Onyewuchi; Shaohua Yang; Ran Liu; James W Simpkins
Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
Brain research 2004;1009(1-2):1-8.
2004: Yi Wen; Shaohua Yang; Ran Liu; Evelyn Perez; Kun Don YI; Peter Koulen; James W Simpkins
Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia.
Brain research 2004;1008(2):147-54.
2004: Yi Wen; Shaohua Yang; Ran Liu; Anne-Marie Brun-Zinkernagel; Peter Koulen; James W Simpkins
Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats.
The Journal of biological chemistry 2004;279(21):22684-92.
2004: Patrick R Cammarata; Shaoyou Chu; Andrea N Moor; Zhaohui Wang; Shao-Hua Yang; James W Simpkins
Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells.
Experimental eye research 2004;78(4):861-71.
2004: Shao-Hua Yang; Ran Liu; Evelyn J Perez; Yi Wen; Stanley M Stevens; Thomas Valencia; Anne-Marie Brun-Zinkernagel; Laszlo Prokai; Yvonne Will; James A Dykens; Peter Koulen; James W Simpkins
Mitochondrial localization of estrogen receptor beta.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4130-5.
2003: Tao Fan; Shao-Hua Yang; Erik Johnson; Barbara Osteen; Ronald Hayes; Arthur L Day; James W Simpkins
17beta-Estradiol extends ischemic thresholds and exerts neuroprotective effects in cerebral subcortex against transient focal cerebral ischemia in rats.
Brain research 2003;993(1-2):10-7.
2003: Shao-Hua Yang; Ran Liu; Samuel S Wu; James W Simpkins
The use of estrogens and related compounds in the treatment of damage from cerebral ischemia.
Annals of the New York Academy of Sciences 2003;1007():101-7.
2003: Laszlo Prokai; Katalin Prokai-Tatrai; Pal Perjesi; Alevtina D Zharikova; Evelyn J Perez; Ran Liu; James W Simpkins
Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11741-6.
2003: Mridula Rewal; Marianna E Jung; Yi Wen; Anne-Marie Brun-Zinkernagel; James W Simpkins
Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal.
Alcohol (Fayetteville, N.Y.) 2003;31(1-2):49-61.
2003: Marianna E Jung; David G Watson; Yi Wen; James W Simpkins
Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn rats.
Alcohol (Fayetteville, N.Y.) 2003;31(1-2):39-48.
2003: Paul Aoun; David G Watson; James W Simpkins
Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells.
European journal of pharmacology 2003;472(1-2):65-71.
2003: Simon Kaja; Shao-Hua Yang; Jiao Wei; Kazuko Fujitani; Ran Liu; Anne-Marie Brun-Zinkernagel; James W Simpkins; Kaoru Inokuchi; Peter Koulen
Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections.
Investigative ophthalmology & visual science 2003;44(7):3155-62.
2003: Paul Aoun; James W Simpkins; Neeraj Agarwal
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells.
Investigative ophthalmology & visual science 2003;44(7):2999-3004.
2003: Laszlo Prokai; Katalin Prokai-Tatrai; Pal Perjesi; Alevtina D Zharikova; James W Simpkins
Quinol-based metabolic cycle for estrogens in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(6):701-4.
2003: Xiaofei Wang; James W Simpkins; James A Dykens; Patrick R Cammarata
Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability.
Investigative ophthalmology & visual science 2003;44(5):2067-75.
2003: James A Dykens; James W Simpkins; J Wang; K Gordon
Polycyclic phenols, estrogens and neuroprotection: a proposed mitochondrial mechanism.
Experimental gerontology 2003;38(1-2):101-7.
2002: Ran Liu; Shao-Hua Yang; Evelyn Perez; Kun Don YI; Samuel S Wu; Kathleen Eberst; Laszlo Prokai; Katalin Prokai-Tatrai; Zu Yun Cai; Douglas F Covey; Arthur L Day; James W Simpkins
Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis.
Stroke; a journal of cerebral circulation 2002;33(10):2485-91.
2002: Marianna E Jung; Shao H Yang; Anne-Marie Brun-Zinkernagel; James W Simpkins
Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn rats.
Alcohol (Fayetteville, N.Y.) 2002;26(2):83-93.
2002: Zhen He; Yun-Ju He; Arthur L Day; James W Simpkins
Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: perfusion-dependent and-independent mechanisms.
Journal of the neurological sciences 2002;193(2):79-87.
2002: Shao-Hua Yang; Evelyn Perez; Jason Cutright; Ran Liu; Zhen He; Arthur L Day; James W Simpkins
Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(1):195-201.
2001: J Wang; Pattie Green; James W Simpkins
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.
Journal of neurochemistry 2001;77(3):804-11.
2001: Y Liang; S Belford; F Tang; Laszlo Prokai; James W Simpkins; J A Hughes
Membrane fluidity effects of estratrienes.
Brain research bulletin 2001;54(6):661-8.
2001: S H Yang; Z He; S S Wu; Yun-Ju He; Jason Cutright; William J Millard; Arthur L Day; James W Simpkins
17-beta estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(2):174-81.
2001: Laszlo Prokai; S M Oon; Katalin Prokai-Tatrai; Khalil A Abboud; James W Simpkins
Synthesis and biological evaluation of 17beta-alkoxyestra-1,3, 5(10)-trienes as potential neuroprotectants against oxidative stress.
Journal of medicinal chemistry 2001;44(1):110-4.
2000: Pattie Green; Evelyn J Perez; T Calloway; James W Simpkins
Estradiol attenuation of beta-amyloid-induced toxicity: a comparison o.
Journal of neurocytology 2000;29(5-6):419-23.
2000: S H Yang; Jiong Shi; Arthur L Day; James W Simpkins
Estradiol exerts neuroprotective effects when administered after ischemic insult.
Stroke; a journal of cerebral circulation 2000;31(3):745-9; discussion 749-50.
2000: Jiong Shi; Shao-Hua Yang; L Stubley; Arthur L Day; James W Simpkins
Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model.
Brain research 2000;853(1):1-4.
2000: Pattie Green; James W Simpkins
Estrogens and estrogen-like non-feminizing compounds. Their role in the prevention and treatment of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;924():93-8.
1998: Jiong Shi; Kiran Panickar; Shao-Hua Yang; Omid Rabbani; Arthur L Day; James W Simpkins
Estrogen attenuates over-expression of beta-amyloid precursor protein messager RNA in an animal model of focal ischemia.
Brain research 1998;810(1-2):87-92.
1998: Kelly E Gridley; Pattie Green; James W Simpkins
A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro.
Molecular pharmacology 1998;54(5):874-80.
1998: James W Simpkins; Omid Rabbani; Jiong Shi; Kiran Panickar; Pattie Green; Arthur L Day
A system for the brain-enhanced delivery of estradiol: an assessment of its potential for the treatment of Alzheimer's disease and stroke.
Die Pharmazie 1998;53(8):505-11.
1998: T Hawk; YQ Zhang; G Rajakumar; Arthur L Day; James W Simpkins
Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats.
Brain research 1998;796(1-2):296-8.
1998: Pattie Green; Kelly E Gridley; James W Simpkins
Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione.
Neuroscience 1998;84(1):7-10.
1998: Kiran Panickar; K Purushotham; Michael A King; G Rajakumar; James W Simpkins
Hypoglycemia-induced seizures reduce cyclic AMP response element binding protein levels in the rat hippocampus.
Neuroscience 1998;83(4):1155-60.
1998: YQ Zhang; Jiong Shi; G Rajakumar; Arthur L Day; James W Simpkins
Effects of gender and estradiol treatment on focal brain ischemia.
Brain research 1998;784(1-2):321-4.
1997: Kelly E Gridley; Pattie Green; James W Simpkins
Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells.
Brain research 1997;778(1):158-65.
1997: Kiran Panickar; G Guan; Michael A King; G Rajakumar; James W Simpkins
17beta-estradiol attenuates CREB decline in the rat hippocampus following seizure.
Journal of neurobiology 1997;33(7):961-7.
1997: Jiong Shi; Y Q Zhang; James W Simpkins
Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1997;117(2):200-6.
1997: James W Simpkins; G Rajakumar; YQ Zhang; CE Simpkins; D Greenwald; C J Yu; N Bodor; Arthur L Day
Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.
Journal of neurosurgery 1997;87(5):724-30.
1997: Jiong Shi; Y Xiang; James W Simpkins
Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells.
Brain research 1997;772(1-2):247-51.
1997: James W Simpkins; Pattie Green; Kelly E Gridley; Meharvan Singh; N C de Fiebre; G Rajakumar
Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease.
The American journal of medicine 1997;103(3A):19S-25S.
1997: Omid Rabbani; Kiran Panickar; G Rajakumar; Michael A King; N Bodor; Edwin M Meyer; James W Simpkins
17 beta-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum.
Experimental neurology 1997;146(1):179-86.
1997: Jiong Shi; James W Simpkins
17 beta-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier.
The American journal of physiology 1997;272(6 Pt 1):E1016-22.
1997: Pattie Green; J Bishop; James W Simpkins
17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):511-5.
1996: Pattie Green; Kelly E Gridley; James W Simpkins
Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells.
Neuroscience letters 1996;218(3):165-8.
1996: V Srinivasan; D Wielbo; James W Simpkins; Janet L Karlix; Kenneth B Sloan; Ian R Tebbett
Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide.
Pharmaceutical research 1996;13(2):296-300.
1995: Meharvan Singh; Edwin M Meyer; James W Simpkins
The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.
Endocrinology 1995;136(5):2320-4.
1995: James W Simpkins
Effects of age, reproductive status and ambient temperature on skin temperature regulation in the female rat.
Maturitas 1995;21(2):97-102.
1995: J Bishop; James W Simpkins
Estradiol enhances brain glucose uptake in ovariectomized rats.
Brain research bulletin 1995;36(3):315-20.
1994: James W Simpkins
Effects of age and ovarian steroids on responses to opiates in the female rat.
Neurobiology of aging 1994;15(4):545-52.
1994: Meharvan Singh; Edwin M Meyer; William J Millard; James W Simpkins
Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.
Brain research 1994;644(2):305-12.
1994: James W Simpkins
Effects of aging on morphine withdrawal in the rat.
Experimental gerontology 1994;29(1):67-76.
1994: James W Simpkins; Meharvan Singh; J Bishop
The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease.
Neurobiology of aging 1994;15 Suppl 2():S195-7.
1993: James W Simpkins; W J Millard; L A Berglund
Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats.
Life sciences 1993;52(17):1443-50.
1993: S H Yoon; Nicholas Bodor; James W Simpkins
Synthesis and in vitro dopaminergic activity of (2-aminoethyl)-1-hydroxy-2-pyridone type dopamine analogs.
Drug design and discovery 1993;10(1):35-44.
1992: Meharvan Singh; W J Millard; M P Layden; T M Romano; James W Simpkins
Opiate stimulation of prolactin secretion is reversed by ovarian hormone treatment.
Neuroendocrinology 1992;56(2):195-203.
1992: James W Simpkins
Effects of advancing age on cerebrospinal fluid concentrations of prolactin in the female rat.
Brain research 1992;582(2):357-8.
1992: Meharvan Singh; James W Simpkins; M P Layden; T M Romano; W J Millard
Opiate modulation of growth hormone secretion is compromised during the steroid-induced luteinizing hormone surge.
Neuroendocrinology 1992;55(2):214-20.
1992: James W Simpkins
Effects of haloperidol and prolactin secreting tumors on cerebrospinal fluid concentrations of prolactin in the female rat.
Life sciences 1992;51(4):295-301.
1991: Joanna Peris; N Decambre; M L Coleman-Hardee; James W Simpkins
Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release.
Brain research 1991;566(1-2):255-64.
1991: James W Simpkins
Solubilization of ovine growth hormone with 2-hydroxypropyl-beta-cyclodextrin.
Journal of parenteral science and technology : a publication of the Parenteral Drug Association 1991;45(6):266-9.
1991: R Ganesan; James W Simpkins
Conditioned taste aversion induced by estradiol pellets.
Physiology & behavior 1991;50(4):849-52.
1991: James W Simpkins; D Swager; W J Millard
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist.
Neuroendocrinology 1991;54(4):384-90.
1991: R Ganesan; T Romano; James W Simpkins
Comparison of morphine tolerance in body temperature and luteinizing hormone secretion.
Physiology & behavior 1991;50(3):505-9.
1991: W R Anderson; M H Rahimy; ME Brewster; Nicholas Bodor; James W Simpkins
The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues. II. The role of testosterone.
Endocrinology 1991;129(2):726-33.
1991: M H Rahimy; W R Anderson; ME Brewster; Nicholas Bodor; James W Simpkins
The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues. I. Dose-response and time-course evaluation.
Endocrinology 1991;129(2):717-25.
1991: A Ratka; Günther Hochhaus; R N Wissler; James W Simpkins
cAMP accumulation in opioid-sensitive SH-SY5Y neuroblastoma cells is modified by estradiol and progesterone.
Molecular and cellular endocrinology 1991;78(3):155-62.
1991: A Ratka; James W Simpkins
Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats.
Hormones and behavior 1991;25(2):217-28.
1991: ME Brewster; M S Hora; James W Simpkins; Nicholas Bodor
Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs.
Pharmaceutical research 1991;8(6):792-5.
1991: L A Berglund; James W Simpkins
Luteinizing hormone-releasing hormone alters the hypothalamic effects of morphine in the rat.
Endocrinology 1991;128(6):2799-804.
1991: M H Rahimy; Nicholas Bodor; James W Simpkins
Effects of a brain-enhanced estrogen delivery system on tail-skin temperature of the rat: implications for menopausal hot flush.
Maturitas 1991;13(1):51-63.
1990: M H Rahimy; James W Simpkins; Nicholas Bodor
Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain. II. Pharmacodynamic responses.
Pharmaceutical research 1990;7(11):1107-12.
1990: R Ganesan; James W Simpkins
The role of conditioned taste aversion in the suppression of food intake by estradiol.
Physiology & behavior 1990;48(5):647-52.
1990: M H Rahimy; James W Simpkins; Nicholas Bodor
Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain. I. Tissue distribution.
Pharmaceutical research 1990;7(10):1061-7.
1990: W J Millard; T M Romano; Nicholas Bodor; James W Simpkins
Growth hormone (GH) secretory dynamics in animals administered estradiol utilizing a chemical delivery system.
Pharmaceutical research 1990;7(10):1011-8.
1990: L A Berglund; W J Millard; S M Gabriel; James W Simpkins
Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat.
Neuroendocrinology 1990;52(3):303-8.
1990: A Ratka; James W Simpkins
A modulatory role for luteinizing hormone-releasing hormone in nociceptive responses of female rats.
Endocrinology 1990;127(2):667-73.
1990: W J Millard; T M Romano; James W Simpkins
Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats.
Neurobiology of aging 1990;11(3):229-35.
1990: M H Rahimy; James W Simpkins; Nicholas Bodor
Tissue distribution of a brain-enhanced chemical delivery system for estradiol.
Drug design and delivery 1990;6(1):29-40.
1990: James W Simpkins; D K Andreadis; W J Millard; Michael J Katovich
The effect of cellular glucoprivation on skin temperature regulation in the rat.
Life sciences 1990;47(2):107-15.
1990: A Ratka; James W Simpkins
Dose-dependent effects of chronic treatment with estradiol or progesterone on LH secretion in ovariectomized rats.
Endocrine research 1990;16(2):165-84.
1990: James W Simpkins; Michael J Katovich; W J Millard
Glucose modulation of skin temperature responses during morphine withdrawal in the rat.
Psychopharmacology 1990;102(2):213-20.
1989: Michael J Katovich; James W Simpkins; J O'Meara
Effects of acute central LH-RH administration of the skin temperature response in morphine dependent rats.
Brain research 1989;494(1):85-94.
1989: M H Rahimy; Nicholas Bodor; James W Simpkins
A rapid, sensitive method for the simultaneous quantitation of estradiol and estradiol conjugates in a variety of tissues: assay development and evaluation of the distribution of a brain-enhanced estradiol-chemical delivery system.
Journal of steroid biochemistry 1989;33(2):179-87.
1989: James W Simpkins; W R Anderson; R Dawson; Nicholas Bodor
Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats.
Pharmaceutical research 1989;6(7):592-600.
1989: Ralph Dawson; James W Simpkins; David R Wallace
Age- and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats.
Neurotoxicology and teratology 1989;11(4):331-7.
1989: W R Anderson; James W Simpkins; ME Brewster; N S Bodor
Evidence for prolonged suppression of stress-induced release of adrenocorticotropic hormone and corticosterone with a brain-enhanced dexamethasone-redox delivery system.
Neuroendocrinology 1989;50(1):9-16.
1989: C Lindsay DeVane; James W Simpkins; R L Miller; S B Braun
Tissue distribution of cocaine in the pregnant rat.
Life sciences 1989;45(14):1271-6.
1989: L A Berglund; W R Millington; James W Simpkins
Gonadal steroid and chronic morphine treatment do not change the posttranslational processing of beta-endorphin in the rat brain.
Life sciences 1989;44(9):591-601.
1988: L A Berglund; James W Simpkins
Alterations in brain opiate receptor mechanisms on proestrous afternoon.
Neuroendocrinology 1988;48(4):394-400.
1988: John T Clark; S M Gabriel; James W Simpkins; Satya P Kalra; Pushpa S Kalra
Chronic morphine and testosterone treatment. Effects on sexual behavior and dopamine metabolism in male rats.
Neuroendocrinology 1988;48(1):97-104.
1988: L A Berglund; Hartmut Derendorf; James W Simpkins
Desensitization of brain opiate receptor mechanisms by gonadal steroid treatments that stimulate luteinizing hormone secretion.
Endocrinology 1988;122(6):2718-26.
1988: W R Anderson; James W Simpkins; ME Brewster; Nicholas Bodor
Brain-enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydroxypropyl-beta-cyclodextrin.
Drug design and delivery 1988;2(4):287-98.
1988: S M Gabriel; John T Clark; Pushpa S Kalra; Satya P Kalra; James W Simpkins
Chronic morphine and testosterone treatment: effects on norepinephrine and serotonin metabolism and gonadotropin secretion in male rats.
Brain research 1988;447(1):200-3.
1988: W R Anderson; James W Simpkins; ME Brewster; Nicholas Bodor
Evidence for suppression of serum LH without elevation in serum estradiol or prolactin with a brain-enhanced redox delivery system for estradiol.
Life sciences 1988;42(16):1493-502.
1988: James W Simpkins; M Smulkowski; R Dixon; R Tuttle
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
The Journal of pharmacology and experimental therapeutics 1988;244(1):195-205.
1988: James W Simpkins; W R Anderson; R Dawson; A Seth; M Brewster; K S Estes; Nicholas Bodor
Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol.
Physiology & behavior 1988;44(4-5):573-80.
1988: W R Anderson; James W Simpkins; ME Brewster; Nicholas Bodor
Effects of a brain-enhanced chemical delivery system for estradiol on body weight and serum hormones in middle-aged male rats.
Endocrine research 1988;14(2-3):131-48.
1987: James W Simpkins; W J Millard
Influence of age on neurotransmitter function.
Endocrinology and metabolism clinics of North America 1987;16(4):893-917.
1987: Michael J Katovich; James W Simpkins; C C Barney
Alpha-adrenergic mediation of the tail skin temperature response to naloxone in morphine-dependent rats.
Brain research 1987;426(1):55-61.
1987: James W Simpkins; M J Katovich
Role of hypothermia in the pentobarbital-induced blockade of luteinizing hormone secretion in female rats.
Neuroendocrinology 1987;46(3):217-21.
1987: Michael J Katovich; James W Simpkins; I C Song; J O'Meara
Effects of central application of naloxone on the skin temperature response in morphine-dependent rats.
Brain research bulletin 1987;19(1):81-5.
1987: S M Gabriel; L A Berglund; James W Simpkins
Chronic morphine treatment enhances the negative and positive feedback effects of estradiol on gonadotropin secretion in ovariectomized rats.
Endocrinology 1987;120(5):1799-805.
1987: K S Estes; ME Brewster; James W Simpkins; Nicholas Bodor
A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats.
Life sciences 1987;40(13):1327-34.
1986: S M Gabriel; L A Berglund; S P Kalra; P S Kalra; James W Simpkins
The influence of chronic morphine treatment on the negative feedback regulation of gonadotropin secretion by gonadal steroids.
Endocrinology 1986;119(6):2762-7.
1986: Michael J Katovich; James W Simpkins; J O'Meara
Effects of opioid antagonists and their quaternary analogs on temperature changes in morphine-dependent rats.
Life sciences 1986;39(20):1845-54.
1986: Michael J Katovich; James W Simpkins; L A Berglund; J O'Meara
Regional skin temperature changes in a rat model for the menopausal hot flush.
Maturitas 1986;8(1):67-76.
1986: S M Gabriel; L A Berglund; James W Simpkins
A decline in endogenous opioid influence during the steroid-induced hypersecretion of luteinizing hormone in the rat.
Endocrinology 1986;118(2):558-61.