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Virgil Simplaceanu

Research Profile

Phenomena

Chemicals & Drugs

Procedures

Nuclear Magnetic Resonance, Biomolecular

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Physiology

Living Beings

Escherichia coli

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Publications

TOP 3
Yue Yuan; Kevin L Campbell; Alan Cooper; Priyamvada Gupta; Nancy T Ho; Michael Hofreiter; Tong-Jian Shen; Virgil Simplaceanu; Tsuey-Chyi S Tam; Chien Ho
A biochemical--biophysical study of hemoglobins from woolly mammoth, Asian elephant, and humans.
Mauro Tiso; Jesus Tejero; Swati Basu; Ivan Azarov; Xunde Wang; Virgil Simplaceanu; Sheila Frizzell; Thottala Jayaraman; Lisa Geary; Calli Shapiro; Chien Ho; Sruti Shiva; Daniel B Kim-Shapiro; Mark T Gladwin
Human neuroglobin functions as a redox-regulated nitrite reductase.
Pravat K Mandal; Virgil Simplaceanu; Vincenzo Fodale
Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study.

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All Publications

2011: Yue Yuan; Kevin L Campbell; Alan Cooper; Priyamvada Gupta; Nancy T Ho; Michael Hofreiter; Tong-Jian Shen; Virgil Simplaceanu; Tsuey-Chyi S Tam; Chien Ho
A biochemical--biophysical study of hemoglobins from woolly mammoth, Asian elephant, and humans.
Biochemistry 2011;50(34):7350-60.
2011: Mauro Tiso; Jesus Tejero; Swati Basu; Ivan Azarov; Xunde Wang; Virgil Simplaceanu; Sheila Frizzell; Thottala Jayaraman; Lisa Geary; Calli Shapiro; Chien Ho; Sruti Shiva; Daniel B Kim-Shapiro; Mark T Gladwin
Human neuroglobin functions as a redox-regulated nitrite reductase.
The Journal of biological chemistry 2011;286(20):18277-89.
2010: Pravat K Mandal; Virgil Simplaceanu; Vincenzo Fodale
Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study.
Journal of Alzheimer's disease : JAD 2010;20(1):127-34.
2008: David H Maillett; Virgil Simplaceanu; Tong-Jian Shen; Nancy T Ho; John S Olson; Chien Ho
Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin.
Biochemistry 2008;47(40):10551-63.
2008: Xiang-jin Song; Virgil Simplaceanu; Nancy T Ho; Chien Ho
Effector-induced structural fluctuation regulates the ligand affinity of an allosteric protein: binding of inositol hexaphosphate has distinct dynamic consequences for the T and R states of hemoglobin.
Biochemistry 2008;47(17):4907-15.
2007: Sarata C Sahu; Virgil Simplaceanu; Qingguo Gong; Nancy T Ho; Fang Tian; James H Prestegard; Chien Ho
Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effector.
Biochemistry 2007;46(35):9973-80.
2007: Xiang-Jin Song; Yue Yuan; Virgil Simplaceanu; Sarata C Sahu; Nancy T Ho; Chien Ho
A comparative NMR study of the polypeptide backbone dynamics of hemoglobin in the deoxy and carbonmonoxy forms.
Biochemistry 2007;46(23):6795-803.
2007: Dongxia Li; Belur N Manjula; Nancy T Ho; Virgil Simplaceanu; Chien Ho; Seetharama A Acharya
Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb].
Artificial cells, blood substitutes, and immobilization biotechnology 2007;35(1):19-29.
2006: Sarata C Sahu; Virgil Simplaceanu; Qingguo Gong; Nancy T Ho; John G Glushka; James H Prestegard; Chien Ho
Orientation of deoxyhemoglobin at high magnetic fields: structural insights from RDCs in solution.
Journal of the American Chemical Society 2006;128(19):6290-1.
2006: Qingguo Gong; Virgil Simplaceanu; Jonathan A Lukin; Janel L Giovannelli; Nancy T Ho; Chien Ho
Quaternary structure of carbonmonoxyhemoglobins in solution: structural changes induced by the allosteric effector inositol hexaphosphate.
Biochemistry 2006;45(16):5140-8.
2006: Janina Kneipp; Gurusamy Balakrishnan; Ruopian Chen; Tong-Jian Shen; Sarata C Sahu; Nancy T Ho; Janel L Giovannelli; Virgil Simplaceanu; Chien Ho; Thomas G Spiro
Dynamics of allostery in hemoglobin: roles of the penultimate tyrosine H bonds.
Journal of molecular biology 2006;356(2):335-53.
2006: Sarata C Sahu; Virgil Simplaceanu; Nancy T Ho; Janel L Giovannelli; Chien Ho
Backbone resonance assignment of human adult hemoglobin in the deoxy form.
Journal of biomolecular NMR 2006;36 Suppl 1():1.
2005: Ming F Tam; Jun Chen; Tsuey-Chyi S Tam; Ching-Hsuan Tsai; Tong-Jian Shen; Virgil Simplaceanu; Timothy N Feinstein; Doug Barrick; Chien Ho
Enhanced inhibition of polymerization of sickle cell hemoglobin in the presence of recombinant mutants of human fetal hemoglobin with substitutions at position 43 in the gamma-chain.
Biochemistry 2005;44(36):12188-95.
2005: Mary Ellen Wiltrout; Janel L Giovannelli; Virgil Simplaceanu; Jonathan A Lukin; Nancy T Ho; Chien Ho
A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets.
Biochemistry 2005;44(19):7207-17.
2004: Jonathan A Lukin; Georg Kontaxis; Virgil Simplaceanu; Yue Yuan; Adriaan Bax; Chien Ho
Backbone resonance assignments of human adult hemoglobin in the carbonmonoxy form.
Journal of biomolecular NMR 2004;28(2):203-4.
2004: Doug Barrick; Jonathan A Lukin; Virgil Simplaceanu; Chien Ho
Nuclear magnetic resonance spectroscopy in the study of hemoglobin cooperativity.
Methods in enzymology 2004;379():28-54.
2003: Jonathan A Lukin; Georg Kontaxis; Virgil Simplaceanu; Yue Yuan; Adriaan Bax; Chien Ho
Quaternary structure of hemoglobin in solution.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):517-20.
2003: Ching-Hsuan Tsai; Virgil Simplaceanu; Nancy T Ho; Tong-Jian Shen; Daojing Wang; Thomas G Spiro; Chien Ho
Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation.
Biophysical chemistry 2003;100(1-3):131-42.
2002: Yi Cheng; Tong-Jian Shen; Virgil Simplaceanu; Chien Ho
Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine.
Biochemistry 2002;41(39):11901-13.
2002: Yue Yuan; Virgil Simplaceanu; Jonathan A Lukin; Chien Ho
NMR investigation of the dynamics of tryptophan side-chains in hemoglobins.
Journal of molecular biology 2002;321(5):863-78.
2002: Chung-ke Chang; Virgil Simplaceanu; Chien Ho
Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces.
Biochemistry 2002;41(17):5644-55.
2001: Doug Barrick; Nancy T Ho; Virgil Simplaceanu; Chien Ho
Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins.
Biochemistry 2001;40(13):3780-95.
2000: Tsuei-Yun Fang; Virgil Simplaceanu; Ching-Hsuan Tsai; Nancy T Ho; Chien Ho
An additional H-bond in the alpha 1 beta 2 interface as the structural basis for the low oxygen affinity and high cooperativity of a novel recombinant hemoglobin (beta L105W).
Biochemistry 2000;39(45):13708-18.
2000: Jonathan A Lukin; Virgil Simplaceanu; M Zou; Nancy T Ho; Chien Ho
NMR reveals hydrogen bonds between oxygen and distal histidines in oxyhemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10354-8.
2000: Virgil Simplaceanu; Jonathan A Lukin; Tsuei-Yun Fang; M Zou; Nancy T Ho; Chien Ho
Chain-selective isotopic labeling for NMR studies of large multimeric proteins: application to hemoglobin.
Biophysical journal 2000;79(2):1146-54.
1999: Tsuei-Yun Fang; M Zou; Virgil Simplaceanu; Nancy T Ho; Chien Ho
Assessment of roles of surface histidyl residues in the molecular basis of the Bohr effect and of beta 143 histidine in the binding of 2,3-bisphosphoglycerate in human normal adult hemoglobin.
Biochemistry 1999;38(40):13423-32.
1997: Tong-Jian Shen; Nancy T Ho; M Zou; DP Sun; P F Cottam; Virgil Simplaceanu; Ming F Tam; D A Bell; Chien Ho
Production of human normal adult and fetal hemoglobins in Escherichia coli.
Protein engineering 1997;10(9):1085-97.
1997: J Yu; Virgil Simplaceanu; N L Tjandra; P F Cottam; Jonathan A Lukin; Chien Ho
1H, 13C, and 15N NMR backbone assignments and chemical-shift-derived secondary structure of glutamine-binding protein of Escherichia coli.
Journal of biomolecular NMR 1997;9(2):167-80.
1997: Doug Barrick; Nancy T Ho; Virgil Simplaceanu; Frederick W Dahlquist; C Ho
A test of the role of the proximal histidines in the Perutz model for cooperativity in haemoglobin.
Nature structural biology 1997;4(1):78-83.
1996: Z Y Sun; E A Pratt; Virgil Simplaceanu; Chien Ho
A 19F-NMR study of the equilibrium unfolding of membrane-associated D-lactate dehydrogenase of Escherichia coli.
Biochemistry 1996;35(51):16502-9.
1995: B K Fetler; Virgil Simplaceanu; Chien Ho
1H-NMR investigation of the oxygenation of hemoglobin in intact human red blood cells.
Biophysical journal 1995;68(2):681-93.
1993: M C Schrader; Virgil Simplaceanu; Chien Ho
Measurement of fluxes through the pentose phosphate pathway in erythrocytes from individuals with sickle cell anemia by carbon-13 nuclear magnetic resonance spectroscopy.
Biochimica et biophysica acta 1993;1182(2):179-88.
1993: M C Schrader; C J Eskey; Virgil Simplaceanu; Chien Ho
A carbon-13 nuclear magnetic resonance investigation of the metabolic fluxes associated with glucose metabolism in human erythrocytes.
Biochimica et biophysica acta 1993;1182(2):162-78.
1993: Tong-Jian Shen; Nancy T Ho; Virgil Simplaceanu; M Zou; B N Green; M F Tam; Chien Ho
Production of unmodified human adult hemoglobin in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8108-12.
1992: N Tjandra; Virgil Simplaceanu; P F Cottam; Chien Ho
Multidimensional 1H and 15N NMR investigation of glutamine-binding protein of Escherichia coli.
Journal of biomolecular NMR 1992;2(2):149-60.
1989: Q C Shen; Virgil Simplaceanu; P F Cottam; J L Wu; J S Hong; Chien Ho
Molecular genetic, biochemical and nuclear magnetic resonance studies on the role of the tryptophan residues of glutamine-binding protein from Escherichia coli.
Journal of molecular biology 1989;210(4):859-67.
1989: Q C Shen; Virgil Simplaceanu; P F Cottam; Chien Ho
Proton nuclear magnetic resonance studies on glutamine-binding protein from Escherichia coli. Formation of intermolecular and intramolecular hydrogen bonds upon ligand binding.
Journal of molecular biology 1989;210(4):849-57.
1989: Zheng-Yu Peng; N Tjandra; Virgil Simplaceanu; Chien Ho
Slow motions in oriented phospholipid bilayers and effects of cholesterol or gramicidin. A 19F-NMR T1 rho study.
Biophysical journal 1989;56(5):877-85.
1989: Zheng-Yu Peng; Virgil Simplaceanu; S R Dowd; Chien Ho
Effects of cholesterol or gramicidin on slow and fast motions of phospholipids in oriented bilayers.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8758-62.
1989: S D Buckel; P F Cottam; Virgil Simplaceanu; Chien Ho
Formation of intermolecular and intramolecular hydrogen bonds in histidine-binding protein J of Salmonella typhimurium upon binding L-histidine. A proton nuclear magnetic resonance study.
Journal of molecular biology 1989;208(3):477-89.
1988: Zheng-Yu Peng; Virgil Simplaceanu; Irving J Lowe; Chien Ho
Rotating-frame relaxation studies of slow motions in fluorinated phospholipid model membranes.
Biophysical journal 1988;54(1):81-95.
1987: Gordon S Rule; E A Pratt; Virgil Simplaceanu; Chien Ho
Nuclear magnetic resonance and molecular genetic studies of the membrane-bound D-lactate dehydrogenase of Escherichia coli.
Biochemistry 1987;26(2):549-56.
1985: W G Wu; S R Dowd; Virgil Simplaceanu; Zheng-Yu Peng; Chien Ho
19F NMR investigation of molecular motion and packing in sonicated phospholipid vesicles.
Biochemistry 1985;24(25):7153-61.
1984: S R Dowd; Virgil Simplaceanu; Chien Ho
Fluorine-19 nuclear magnetic resonance investigation of fluorine-19-labeled phospholipids. 2. A line-shape analysis.
Biochemistry 1984;23(25):6142-6.
1984: J F Post; P F Cottam; Virgil Simplaceanu; Chien Ho
Fluorine-19 nuclear magnetic resonance study of 5-fluorotryptophan-labeled histidine-binding protein J of Salmonella typhimurium.
Journal of molecular biology 1984;179(4):729-43.
1982: M Engelsberg; S R Dowd; Virgil Simplaceanu; B W Cook; Chien Ho
Nuclear magnetic resonance line-shape analysis of fluorine-19-labeled phospholipids.
Biochemistry 1982;21(26):6985-9.