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David Simpson

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Josephine V Glenn; Helen Mahaffy; Keqiang Wu; Gill Smith; Ryoji Nagai; David A C Simpson; Michael E Boulton; Alan Stitt
Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.
Amit Arora; David A C Simpson
Individual mRNA expression profiles reveal the effects of specific microRNAs.
Amit Arora; Gareth J McKay; David A C Simpson
Prediction and verification of miRNA expression in human and rat retinas.

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All Publications

2009: Josephine V Glenn; Helen Mahaffy; Keqiang Wu; Gill Smith; Ryoji Nagai; David A C Simpson; Michael E Boulton; Alan Stitt
Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.
Investigative ophthalmology & visual science 2009;50(1):441-51.
2008: Amit Arora; David A C Simpson
Individual mRNA expression profiles reveal the effects of specific microRNAs.
Genome biology 2008;9(5):R82.
2007: Amit Arora; Gareth J McKay; David A C Simpson
Prediction and verification of miRNA expression in human and rat retinas.
Investigative ophthalmology & visual science 2007;48(9):3962-7.
2007: Mary K McGahon; Durga P Dash; Aruna Arora; Noreen Wall; Jennine Dawicki; David A C Simpson; C Norman Scholfield; J Graham McGeown; Tim M Curtis
Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle.
Circulation research 2007;100(5):703-11.
2007: Mary K McGahon; Jennine Dawicki; Aruna Arora; David A C Simpson; Tom A Gardiner; Alan Stitt; C Norman Scholfield; J Graham McGeown; Tim M Curtis
Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.
American journal of physiology. Heart and circulatory physiology 2007;292(2):H1001-8.
2006: Tanyth E De Gooyer; Kathryn A Stevenson; Peter Humphries; David A C Simpson; Tom A Gardiner; Alan Stitt
Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.
Investigative ophthalmology & visual science 2006;47(12):5561-8.
2006: Tanyth E De Gooyer; Kathryn A Stevenson; Peter Humphries; David A C Simpson; Tim M Curtis; Tom A Gardiner; Alan Stitt
Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.
Investigative ophthalmology & visual science 2006;47(12):5553-60.
2005: Gareth J McKay; Stephen Clarke; Jason A Davis; David A C Simpson; Giuliana Silvestri
Pigmented paravenous chorioretinal atrophy is associated with a mutation within the crumbs homolog 1 (CRB1) gene.
Investigative ophthalmology & visual science 2005;46(1):322-8.
2005: S McFarlane; Josephine V Glenn; Agnieszka M Lichanska; David A C Simpson; Alan Stitt
Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epithelium.
The British journal of ophthalmology 2005;89(1):107-12.
2004: Gareth J McKay; Stephen Clarke; Anne Hughes; Vivienne McConnell; Dennis W Schultz; Michael L Klein; Giuliana Silvestri; David A C Simpson
A novel diagnostic test detects a low frequency of the hemicentin Gln5345Arg variant among Northern Irish age related macular degeneration patients.
Molecular vision 2004;10():682-7.
2004: Gareth J McKay; Lucinda Campbell; Mike Oliver; Simon Brockbank; David A C Simpson; William J Curry
Preparation of planar retinal specimens: verification by histology, mRNA profiling, and proteome analysis.
Molecular vision 2004;10():240-7.
2003: Orla T Cox; David A C Simpson; Alan Stitt; Tom A Gardiner
Sources of PDGF expression in murine retina and the effect of short-term diabetes.
Molecular vision 2003;9():665-72.
2003: Susan A Feeney; David A C Simpson; Tom A Gardiner; Cliona Boyle; Pamela Jamison; Alan Stitt
Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression.
Investigative ophthalmology & visual science 2003;44(2):839-47.
2002: Agnieszka M Lichanska; David A C Simpson
Application of in silico positional cloning and bioinformatic mutation analysis to the study of eye diseases.
Briefings in bioinformatics 2002;3(1):59-72.
2002: Avril Kennan; Aileen Aherne; Arpad Palfi; Marian Humphries; Alex McKee; Alan Stitt; David A C Simpson; Karin Demtroder; Torben F Orntoft; Carmen Ayuso; Paul F Kenna; G Jane Farrar; Peter Humphries
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.
Human molecular genetics 2002;11(5):547-57.
2001: DJ McKenna; David A C Simpson; Susan A Feeney; Tom A Gardiner; Cliona Boyle; J Nelson; Alan Stitt
Expression of the 67 kDa laminin receptor (67LR) during retinal development: correlations with angiogenesis.
Experimental eye research 2001;73(1):81-92.
2000: David A C Simpson; Susan A Feeney; Cliona Boyle; Alan Stitt
Retinal VEGF mRNA measured by SYBR green I fluorescence: A versatile approach to quantitative PCR.
Molecular vision 2000;6():178-83.
1999: David A C Simpson; G M Murphy; T Bhaduri; Tom A Gardiner; Desmond B Archer; Alan Stitt
Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia.
Biochemical and biophysical research communications 1999;262(2):333-40.
1998: Alan Stitt; J E Moore; J A Sharkey; G Murphy; David A C Simpson; Richard Bucala; H Vlassara; Desmond B Archer
Advanced glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy.
Investigative ophthalmology & visual science 1998;39(13):2517-23.
1998: Alan Stitt; David A C Simpson; C Boocock; Tom A Gardiner; G M Murphy; Desmond B Archer
Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours.
The Journal of pathology 1998;186(3):306-12.
1998: Alan Stitt; D McKenna; David A C Simpson; Tom A Gardiner; Patrick Harriott; Desmond B Archer; J Nelson
The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy.
The American journal of pathology 1998;152(5):1359-65.