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Evan Simpson

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TOP 3
Evan R Simpson; Kristy A Brown
Minireview: obesity and breast cancer: a tale of inflammation and dysregulated metabolism.
Evan R Simpson; Peter J Fuller
Pharmacotherapy: disparate bedfellows in a lasting drug union?
Kristy A Brown; Nirukshi U Samarajeewa; Evan R Simpson
Endocrine-related cancers and the role of AMPK.

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All Publications

2013: Evan R Simpson; Kristy A Brown
Minireview: obesity and breast cancer: a tale of inflammation and dysregulated metabolism.
Molecular endocrinology (Baltimore, Md.) 2013;27(5):715-25.
2013: Evan R Simpson; Peter J Fuller
Pharmacotherapy: disparate bedfellows in a lasting drug union?
Nature reviews. Endocrinology 2013;9(3):135-6.
2013: Kristy A Brown; Nirukshi U Samarajeewa; Evan R Simpson
Endocrine-related cancers and the role of AMPK.
Molecular and cellular endocrinology 2013;366(2):170-9.
2013: Sarah Q To; Kevin Knower; Evan R Simpson; Colin D Clyne
Involvement of early growth response factors in TNFα-induced aromatase expression in breast adipose.
Breast cancer research and treatment 2013;138(1):193-203.
2012: Sarah Q To; Yang Yang; Eriko Abe; Kevin Knower; Yasuhiro Miki; Hironobu Sasano; Evan R Simpson; Koyu Suzuki; Kiyoshi Takagi; Colin D Clyne
Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer.
The Journal of steroid biochemistry and molecular biology 2012;132(3-5):331-8.
2012: Kyren A Lazarus; Evan R Simpson; Dhilushi Wijayakumara; Ashwini L Chand; Colin D Clyne
Therapeutic potential of Liver Receptor Homolog-1 modulators.
The Journal of steroid biochemistry and molecular biology 2012;130(3-5):138-46.
2012: Kevin Knower; Yasuhiro Miki; Hironobu Sasano; Evan R Simpson; Kiyoshi Takagi; Sarah Q To; Colin D Clyne
Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts.
Breast cancer research and treatment 2012;132(2):765-71.
2012: Kristy A Brown; Evan R Simpson
Obesity and breast cancer: mechanisms and therapeutic implications.
Frontiers in bioscience (Elite edition) 2012;4():2515-24.
2011: Nirukshi U Samarajeewa; Evan R Simpson; Fangyuan Yang; Seungmin Ham; Kristy A Brown
Promoter-specific effects of metformin on aromatase transcript expression.
Steroids 2011;76(8):768-71.
2011: Ashwini L Chand; Kerrie A Herridge; Tamara L Howard; Evan R Simpson; Colin D Clyne
Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts.
Steroids 2011;76(8):741-4.
2011: Sharyn Bayne; He Li; Margaret E E Jones; Alex R Pinto; Michelle van Sinderen; Ann Drummond; Evan R Simpson; Jun-Ping Liu
Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo.
Protein & cell 2011;2(4):333-46.
2010: Kristy A Brown; Nicole I Hunger; Maria Docanto; Evan R Simpson
Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase.
Breast cancer research and treatment 2010;123(2):591-6.
2010: Kevin Knower; Sarah Q To; Evan R Simpson; Colin D Clyne
Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts.
Molecular and cellular endocrinology 2010;321(2):123-30.
2010: Nicholas I Fleming; Kevin Knower; Kyren A Lazarus; Peter J Fuller; Evan R Simpson; Colin D Clyne
Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter.
PloS one 2010;5(12):e14389.
2010: He Li; Evan R Simpson; Jun-Ping Liu
Oestrogen, telomerase, ovarian ageing and cancer.
Clinical and experimental pharmacology & physiology 2010;37(1):78-82.
2009: Jenny D Y Chow; Evan R Simpson; Wah Chin Boon
Alternative 5'-untranslated first exons of the mouse Cyp19A1 (aromatase) gene.
The Journal of steroid biochemistry and molecular biology 2009;115(3-5):115-25.
2009: Evan R Simpson
Estrogens and the brain. Preface.
Seminars in reproductive medicine 2009;27(3):205.
2009: Rachel A Hill; Hui Kheng Chua; Margaret E E Jones; Evan R Simpson; Wah Chin Boon
Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice.
Molecular and cellular neurosciences 2009;41(1):1-7.
2009: Michelle L Van Sinderen; Wah Chin Boon; Antwan Ederveen; Helenius J Kloosterboer; Evan R Simpson; Margaret E E Jones
The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice.
Menopause (New York, N.Y.) 2009;16(3):582-8.
2009: Ashwini L Chand; Evan R Simpson; Colin D Clyne
Aromatase expression is increased in BRCA1 mutation carriers.
BMC cancer 2009;9():148.
2008: Kerry J McInnes; Kristy A Brown; Kevin Knower; Ashwini L Chand; Colin D Clyne; Evan R Simpson
Characterisation of aromatase expression in the human adipocyte cell line SGBS.
Breast cancer research and treatment 2008;112(3):429-35.
2008: Sharyn Bayne; Margaret Ee Jones; He Li; Alex R Pinto; Evan R Simpson; Jun-Ping Liu
Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice.
Cell research 2008;18(11):1141-50.
2007: Katherine T Gray; Jennifer L Short; Evan R Simpson; Sabatino Ventura
The effects of targeted deletion of the aromatase enzyme on prostatic contractile responses to noradrenaline in mice.
The Journal of endocrinology 2007;195(3):495-502.
2007: Rachel A Hill; Jenny Chow; Karlheinrich Fritzemeier; Evan R Simpson; Wah Chin Boon
Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively.
Molecular and cellular neurosciences 2007;36(2):146-57.
2007: Margaret E E Jones; Kerry J McInnes; Wah Chin Boon; Evan R Simpson
Estrogen and adiposity--utilizing models of aromatase deficiency to explore the relationship.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):3-7.
2007: Margaret E E Jones; Wah Chin Boon; Kerry J McInnes; Laura Maffei; Cesare Carani; Evan R Simpson
Recognizing rare disorders: aromatase deficiency.
Nature clinical practice. Endocrinology & metabolism 2007;3(5):414-21.
2007: Rachel A Hill; Kerry J McInnes; Emily C H Gong; Margaret E E Jones; Evan R Simpson; Wah Chin Boon
Estrogen deficient male mice develop compulsive behavior.
Biological psychiatry 2007;61(3):359-66.
2006: Kerry J McInnes; Anne Corbould; Evan R Simpson; Margaret E E Jones
Regulation of adenosine 5',monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state.
Endocrinology 2006;147(12):5907-13.
2006: Timothy P Plackett; Orhan K Oz; Evan R Simpson; Elizabeth J Kovacs
Lack of aromatase improves cell-mediated immune response after burn.
Burns : journal of the International Society for Burn Injuries 2006;32(5):577-82.
2006: Niroshani Pathirage; Lisa A Di Nezza; Lois A Salmonsen; Tom Jobling; Evan R Simpson; Colin D Clyne
Expression of aromatase, estrogen receptors, and their coactivators in patients with endometrial cancer.
Fertility and sterility 2006;86(2):469-72.
2006: Margaret E E Jones; Wah Chin Boon; Joseph Proietto; Evan R Simpson
Of mice and men: the evolving phenotype of aromatase deficiency.
Trends in endocrinology and metabolism: TEM 2006;17(2):55-64.
2006: Evan R Simpson; Margaret E E Jones
Of mice and men: the many guises of estrogens.
Ernst Schering Foundation symposium proceedings 2006;(1):45-67.
2005: Rachid Safi; Agnes Kovacic; Stéphanie Gaillard; Yoko Murata; Evan R Simpson; Donald P McDonnell; Colin D Clyne
Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
Cancer research 2005;65(24):11762-70.
2005: Evan R Simpson; Kerry J McInnes
Sex and fat--can one factor handle both?
Cell metabolism 2005;2(6):346-7.
2005: Wah Chin Boon; Jeroen Diepstraten; Jorien van der Burg; Margaret E E Jones; Evan R Simpson; Maarten van den Buuse
Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice.
Brain research. Molecular brain research 2005;140(1-2):127-32.
2005: Marie L Misso; Christina Jang; Jennifer Adams; Jane Tran; Yoko Murata; Robin Bell; Wah Chin Boon; Evan R Simpson; Susan R Davis
Differential expression of factors involved in fat metabolism with age and the menopause transition.
Maturitas 2005;51(3):299-306.
2005: Evan R Simpson; Marie L Misso; Kylie N Hewitt; Rachel A Hill; Wah Chin Boon; Margaret E E Jones; Agnes Kovacic; Jiong Zhou; Colin D Clyne
Estrogen--the good, the bad, and the unexpected.
Endocrine reviews 2005;26(3):322-30.
2005: Marie L Misso; Christina Jang; Jennifer Adams; Jane Tran; Yoko Murata; Robin Bell; Wah Chin Boon; Evan R Simpson; Susan R Davis
Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy.
Menopause (New York, N.Y.) 2005;12(2):210-5.
2005: Kara L Britt; Evan R Simpson; Jock K Findlay
Effects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout mice.
Menopause (New York, N.Y.) 2005;12(2):174-85.
2005: Jiong Zhou; Takashi Suzuki; Agnes Kovacic; Ryoko Saito; Yasuhiro Miki; Takanori Ishida; Takuya Moriya; Evan R Simpson; Hironobu Sasano; Colin D Clyne
Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer.
Cancer research 2005;65(2):657-63.
2005: Ming Yan; Margaret E E Jones; Maria Hernandez; Dongling Liu; Evan R Simpson; Chen Chen
Oestrogen replacement in vivo rescues the dysfunction of pituitary somatotropes in ovariectomised aromatase knockout mice.
Neuroendocrinology 2005;81(3):158-66.
2005: Marie L Misso; Kylie N Hewitt; Wah Chin Boon; Yoko Murata; Margaret E E Jones; Evan R Simpson
Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(1):26-31.
2004: Rachel A Hill; Sueli Pompolo; Margaret E E Jones; Evan R Simpson; Wah Chin Boon
Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice.
Molecular and cellular neurosciences 2004;27(4):466-76.
2004: Kara L Britt; Philippa K Saunders; Stephen J McPherson; Marie L Misso; Evan R Simpson; Jock K Findlay
Estrogen actions on follicle formation and early follicle development.
Biology of reproduction 2004;71(5):1712-23.
2004: Kara L Britt; Peter G Stanton; Marie L Misso; Evan R Simpson; Jock K Findlay
The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad.
Endocrinology 2004;145(8):3950-60.
2004: Vincenzo Pezzi; Rosa Sirianni; Adele Chimento; Marcello Maggiolini; Sonia Bourguiba; Christelle Delalande; Serge Carreau; Sebastiano Andò; Evan R Simpson; Colin D Clyne
Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression.
Endocrinology 2004;145(5):2186-96.
2004: M Watanabe; Evan R Simpson; N Pathirage; S Nakajin; Colin D Clyne
Aromatase expression in the human fetal osteoblastic cell line SV-HFO.
Journal of molecular endocrinology 2004;32(2):533-45.
2004: Kylie N Hewitt; Kyriakos Pratis; Margaret E E Jones; Evan R Simpson
Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse.
Endocrinology 2004;145(4):1842-8.
2004: Colin D Clyne; Agnes Kovacic; Caroline J Speed; Jiong Zhou; Vincenzo Pezzi; Evan R Simpson
Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue.
Molecular and cellular endocrinology 2004;215(1-2):39-44.
2004: Evan R Simpson
Models of aromatase insufficiency.
Seminars in reproductive medicine 2004;22(1):25-30.
2004: Evan R Simpson
Aromatase: biologic relevance of tissue-specific expression.
Seminars in reproductive medicine 2004;22(1):11-23.
2004: Ming Yan; Margaret E E Jones; Maria Hernandez; Dongling Liu; Evan R Simpson; Chen Chen
Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement.
Endocrinology 2004;145(2):604-12.
2004: Evan R Simpson; S McPherson; M Jones; Kirsten Robertson; Wah Chin Boon; G Risbridger
Role of estrogens in the male reproductive tract.
Ernst Schering Research Foundation workshop 2004;(46):89-112.
2004: Agnes Kovacic; Caroline J Speed; Evan R Simpson; Colin D Clyne
Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes.
Molecular endocrinology (Baltimore, Md.) 2004;18(1):252-9.
2003: Louise D McCullough; Kathleen K Blizzard; Evan R Simpson; Orhan K Oz; Patricia D Hurn
Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(25):8701-5.
2003: Kylie N Hewitt; Wah Chin Boon; Yoko Murata; Margaret E E Jones; Evan R Simpson
The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis.
Endocrinology 2003;144(9):3895-903.
2003: Mariam Sofi; Morag J Young; Theodora Papamakarios; Evan R Simpson; Colin D Clyne
Role of CRE-binding protein (CREB) in aromatase expression in breast adipose.
Breast cancer research and treatment 2003;79(3):399-407.
2003: Marie L Misso; Yoko Murata; Wah Chin Boon; Margaret E E Jones; Kara L Britt; Evan R Simpson
Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse.
Endocrinology 2003;144(4):1474-80.
2002: Darshini Karuppu; Alan Kalus; Evan R Simpson; Colin D Clyne
Aromatase and prostaglandin inter-relationships in breast adipose tissue: significance for breast cancer development.
Breast cancer research and treatment 2002;76(2):103-9.
2002: Kara L Britt; Jeff Kerr; Liza O'Donnell; Margaret E E Jones; Ann E Drummond; Susan R Davis; Evan R Simpson; Jock K Findlay
Estrogen regulates development of the somatic cell phenotype in the eutherian ovary.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1389-97.
2002: Kirsten M Robertson; Liza O'Donnell; Evan R Simpson; Margaret E E Jones
The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function.
Endocrinology 2002;143(8):2913-21.
2002: Gary L Rubin; Jenny H Duong; Colin D Clyne; Caroline J Speed; Yoko Murata; Changhong Gong; Evan R Simpson
Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose.
Endocrinology 2002;143(8):2863-71.
2002: Yoko Murata; Kirsten M Robertson; Margaret E E Jones; Evan R Simpson
Effect of estrogen deficiency in the male: the ArKO mouse model.
Molecular and cellular endocrinology 2002;193(1-2):7-12.
2002: Colin D Clyne; Caroline J Speed; Jiong Zhou; Evan R Simpson
Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes.
The Journal of biological chemistry 2002;277(23):20591-7.
2002: Ann E Drummond; Kara L Britt; Mitzi Dyson; Margaret E E Jones; Jeffrey B Kerr; Liza O'Donnell; Evan R Simpson; Jock K Findlay
Ovarian steroid receptors and their role in ovarian function.
Molecular and cellular endocrinology 2002;191(1):27-33.
2002: Evan R Simpson
Aromatization of androgens in women: current concepts and findings.
Fertility and sterility 2002;77 Suppl 4():S6-10.
2002: Evan R Simpson; Mitch Dowsett
Aromatase and its inhibitors: significance for breast cancer therapy.
Recent progress in hormone research 2002;57():317-38.
2002: Evan R Simpson; Colin D Clyne; Gary Rubin; Wah Chin Boon; Kirsten Robertson; Kara L Britt; Caroline J Speed; Margaret Jones
Aromatase--a brief overview.
Annual review of physiology 2002;64():93-127.
2001: Kara L Britt; Ann E Drummond; Mitzi Dyson; Nigel G Wreford; Margaret E E Jones; Evan R Simpson; Jock K Findlay
The ovarian phenotype of the aromatase knockout (ArKO) mouse.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):181-5.
2001: Orhan K Oz; G Hirasawa; J Lawson; L Nanu; Anca Constantinescu; Peter P Antich; Ralph P Mason; EN Tsyganov; RW Parkey; Joseph E Zerwekh; Evan R Simpson
Bone phenotype of the aromatase deficient mouse.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):49-59.
2001: Margaret E E Jones; A W Thorburn; Kara L Britt; Kylie N Hewitt; Marie L Misso; Nigel G Wreford; Joseph Proietto; O K Oz; B J Leury; Kirsten M Robertson; Shenggen Yao; Evan R Simpson
Aromatase-deficient (ArKO) mice accumulate excess adipose tissue.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):3-9.
2001: Evan R Simpson; Colin D Clyne; Caroline J Speed; Gary Rubin; S Bulun
Tissue-specific estrogen biosynthesis and metabolism.
Annals of the New York Academy of Sciences 2001;949():58-67.
2001: Kirsten M Robertson; Evan R Simpson; O Lacham-Kaplan; Margaret E E Jones
Characterization of the fertility of male aromatase knockout mice.
Journal of andrology 2001;22(5):825-30.
2001: Liza O'Donnell; Kirsten M Robertson; Margaret E E Jones; Evan R Simpson
Estrogen and spermatogenesis.
Endocrine reviews 2001;22(3):289-318.
2001: Jock K Findlay; Kara L Britt; Jeffrey B Kerr; Liza O'Donnell; Margaret E E Jones; Ann E Drummond; Evan R Simpson
The road to ovulation: the role of oestrogens.
Reproduction, fertility, and development 2001;13(7-8):543-7.
2000: Evan R Simpson; Susan R Davis
Another role highlighted for estrogens in the male: sexual behavior.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14038-40.
2000: Margaret E E Jones; A W Thorburn; Kara L Britt; Kylie N Hewitt; Nigel G Wreford; Joseph Proietto; O K Oz; B J Leury; Kirsten M Robertson; Shenggen Yao; Evan R Simpson
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12735-40.
2000: Evan R Simpson
Role of aromatase in sex steroid action.
Journal of molecular endocrinology 2000;25(2):149-56.
2000: Margaret E E Jones; Evan R Simpson
Oestrogens in male reproduction.
Baillière's best practice & research. Clinical endocrinology & metabolism 2000;14(3):505-16.
2000: Evan R Simpson
Biology of aromatase in the mammary gland.
Journal of mammary gland biology and neoplasia 2000;5(3):251-8.
2000: Kara L Britt; Ann E Drummond; V A Cox; Mitzi Dyson; Nigel G Wreford; Margaret E E Jones; Evan R Simpson; Jock K Findlay
An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene.
Endocrinology 2000;141(7):2614-23.
2000: Jock K Findlay; Ann E Drummond; Kara L Britt; Mitzi Dyson; Nigel G Wreford; David M Robertson; nigel P groome; Margaret E E Jones; Evan R Simpson
The roles of activins, inhibins and estrogen in early committed follicles.
Molecular and cellular endocrinology 2000;163(1-2):81-7.
2000: VR Agarwal; Christopher M Sinton; C Liang; C Fisher; Dwight C German; Evan R Simpson
Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice.
Molecular and cellular endocrinology 2000;162(1-2):9-16.
2000: Orhan K Oz; Joseph E Zerwekh; C Fisher; KH Graves; L Nanu; R Millsaps; Evan R Simpson
Bone has a sexually dimorphic response to aromatase deficiency.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(3):507-14.
2000: Makio Shozu; Y Zhao; Evan R Simpson
TGF-beta1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells.
Molecular and cellular endocrinology 2000;160(1-2):123-33.
1999: Z Liu; Evan R Simpson
Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression.
Molecular and cellular endocrinology 1999;153(1-2):183-96.
1999: Kirsten M Robertson; Liza O'Donnell; Margaret E E Jones; Sarah J Meachem; Wah Chin Boon; CR Fisher; KH Graves; Robert I McLachlan; Evan R Simpson
Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7986-91.
1998: Evan R Simpson
Genetic mutations resulting in estrogen insufficiency in the male.
Molecular and cellular endocrinology 1998;145(1-2):55-9.
1998: CR Fisher; KH Graves; A F Parlow; Evan R Simpson
Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6965-70.
1998: VR Agarwal; Kazuto Takayama; Judson Vanwyk; Hironobu Sasano; Evan R Simpson; Serdar E Bulun
Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.
The Journal of clinical endocrinology and metabolism 1998;83(5):1797-800.
1998: Makio Shozu; Evan R Simpson
Aromatase expression of human osteoblast-like cells.
Molecular and cellular endocrinology 1998;139(1-2):117-29.
1998: T Sun; Y Zhao; D J Mangelsdorf; Evan R Simpson
Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells.
Endocrinology 1998;139(4):1684-91.
1998: Makio Shozu; Y Zhao; Serdar E Bulun; Evan R Simpson
Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6.
Endocrinology 1998;139(4):1610-7.
1997: Makio Shozu; Y Zhao; Evan R Simpson
Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene.
Endocrinology 1997;138(12):5125-35.
1997: M Dodson Michael; Laura F Michael; Evan R Simpson
A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene.
Molecular and cellular endocrinology 1997;134(2):147-56.
1997: Margaret M Hinshelwood; M Dodson Michael; Evan R Simpson
The 5'-flanking region of the ovarian promoter of the bovine CYP19 gene contains a deletion in a cyclic adenosine 3',5'-monophosphate-like responsive sequence.
Endocrinology 1997;138(9):3704-10.
1997: R Borroni; Z Liu; Evan R Simpson; Margaret M Hinshelwood
A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary.
Endocrinology 1997;138(5):2011-20.
1997: Margaret M Hinshelwood; M Dodson Michael; T Sun; Evan R Simpson
Regulation of aromatase expression in the ovary and placenta: a comparison between two species.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):399-405.
1997: Y Zhao; VR Agarwal; Carole R Mendelson; Evan R Simpson
Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):203-10.
1997: Serdar E Bulun; LS Noble; Kazuto Takayama; M Dodson Michael; VR Agarwal; C Fisher; Y Zhao; Margaret M Hinshelwood; Y Ito; Evan R Simpson
Endocrine disorders associated with inappropriately high aromatase expression.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):133-9.
1997: Z Liu; Evan R Simpson
Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells.
Molecular endocrinology (Baltimore, Md.) 1997;11(2):127-37.
1997: Evan R Simpson; Y Zhao; VR Agarwal; M Dodson Michael; Serdar E Bulun; Margaret M Hinshelwood; SE Graham-Lorence; T Sun; CR Fisher; K Qin; Carole R Mendelson
Aromatase expression in health and disease.
Recent progress in hormone research 1997;52():185-213; discussion 213-4.
1997: Evan R Simpson; M Dodson Michael; VR Agarwal; Margaret M Hinshelwood; Serdar E Bulun; Y Zhao
Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(1):29-36.
1997: VR Agarwal; C I Ashanullah; Evan R Simpson; Serdar E Bulun
Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of women.
The Journal of clinical endocrinology and metabolism 1997;82(1):70-4.
1996: Y Zhao; VR Agarwal; Carole R Mendelson; Evan R Simpson
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
Endocrinology 1996;137(12):5739-42.
1996: VR Agarwal; Serdar E Bulun; M Leitch; R Rohrich; Evan R Simpson
Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.
The Journal of clinical endocrinology and metabolism 1996;81(11):3843-9.
1996: Y Zhao; J E Nichols; R Valdez; Carole R Mendelson; Evan R Simpson
Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1350-7.
1996: M Demeter Arlotto; M Dodson Michael; M W Kilgore; Evan R Simpson
17alpha-Hydroxylase gene expression in the bovine ovary: mechanisms regulating expression differ from those in adrenal cells.
The Journal of steroid biochemistry and molecular biology 1996;59(1):21-9.
1996: Evan R Simpson; Serdar E Bulun; J E Nichols; Y Zhao
Estrogen biosynthesis in adipose tissue: regulation by paracrine and autocrine mechanisms.
The Journal of endocrinology 1996;150 Suppl():S51-7.
1996: J D Rink; Evan R Simpson; Jeffrey J Barnard; Serdar E Bulun
Cellular characterization of adipose tissue from various body sites of women.
The Journal of clinical endocrinology and metabolism 1996;81(7):2443-7.
1996: B A Amarneh; Evan R Simpson
Detection of aromatase cytochrome P450, 17 alpha-hydroxylase cytochrome P450 and NADPH:P450 reductase on the surface of cells in which they are expressed.
Molecular and cellular endocrinology 1996;119(1):69-74.
1996: Evan R Simpson; Y Zhao
Estrogen biosynthesis in adipose. Significance in breast cancer development.
Annals of the New York Academy of Sciences 1996;784():18-26.
1996: M B Crichton; J E Nichols; Y Zhao; Serdar E Bulun; Evan R Simpson
Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells.
Molecular and cellular endocrinology 1996;118(1-2):215-20.
1996: Serdar E Bulun; G Sharda; J Rink; S Sharma; Evan R Simpson
Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast.
The Journal of clinical endocrinology and metabolism 1996;81(3):1273-7.
1996: Alan J Conley; C Jo Corbin; Margaret M Hinshelwood; Z Liu; Evan R Simpson; J J Ford; N Harada
Functional aromatase expression in porcine adrenal gland and testis.
Biology of reproduction 1996;54(2):497-505.
1996: L S Noble; Evan R Simpson; A Johns; Serdar E Bulun
Aromatase expression in endometriosis.
The Journal of clinical endocrinology and metabolism 1996;81(1):174-9.
1995: VR Agarwal; Serdar E Bulun; Evan R Simpson
Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR.
Molecular and cellular probes 1995;9(6):453-64.
1995: Margaret M Hinshelwood; Z Liu; Alan J Conley; Evan R Simpson
Demonstration of tissue-specific promoters in nonprimate species that express aromatase P450 in placentae.
Biology of reproduction 1995;53(5):1151-9.
1995: Y Zhao; J E Nichols; Serdar E Bulun; Carole R Mendelson; Evan R Simpson
Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter.
The Journal of biological chemistry 1995;270(27):16449-57.
1995: M Dodson Michael; M W Kilgore; K Morohashi; Evan R Simpson
Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary.
The Journal of biological chemistry 1995;270(22):13561-6.
1995: S Graham-Lorence; B Amarneh; R E White; Julian A Peterson; Evan R Simpson
A three-dimensional model of aromatase cytochrome P450.
Protein science : a publication of the Protein Society 1995;4(6):1065-80.
1995: B Amarneh; Evan R Simpson
Expression of a recombinant derivative of human aromatase P450 in insect cells utilizing the baculovirus vector system.
Molecular and cellular endocrinology 1995;109(2):R1-5.
1995: Y Zhao; Carole R Mendelson; Evan R Simpson
Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes.
Molecular endocrinology (Baltimore, Md.) 1995;9(3):340-9.
1995: J E Nichols; Serdar E Bulun; Evan R Simpson
Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells.
Journal of the Society for Gynecologic Investigation 1995;2(1):45-50.
1994: Serdar E Bulun; K Economos; D Miller; Evan R Simpson
CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.
The Journal of clinical endocrinology and metabolism 1994;79(6):1831-4.
1994: J M McAllister; W Byrd; Evan R Simpson
The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture.
The Journal of clinical endocrinology and metabolism 1994;79(1):106-12.
1994: Felix A Conte; Melvin M Grumbach; Y Ito; C R Fisher; Evan R Simpson
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).
The Journal of clinical endocrinology and metabolism 1994;78(6):1287-92.
1994: Evan R Simpson; Mala S Mahendroo; G D Means; M W Kilgore; Margaret M Hinshelwood; S Graham-Lorence; B Amarneh; Y Ito; C R Fisher; M Dodson Michael
Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis.
Endocrine reviews 1994;15(3):342-55.
1994: Serdar E Bulun; Mala S Mahendroo; Evan R Simpson
Aromatase gene expression in adipose tissue: relationship to breast cancer.
The Journal of steroid biochemistry and molecular biology 1994;49(4-6):319-26.
1994: Serdar E Bulun; Evan R Simpson; R Ann Word
Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture.
The Journal of clinical endocrinology and metabolism 1994;78(3):736-43.
1994: K Toda; Evan R Simpson; Carole R Mendelson; Y Shizuta; M W Kilgore
Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues.
Molecular endocrinology (Baltimore, Md.) 1994;8(2):210-7.
1994: Serdar E Bulun; Evan R Simpson
Competitive reverse transcription-polymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age.
The Journal of clinical endocrinology and metabolism 1994;78(2):428-32.
1994: Serdar E Bulun; I M Rosenthal; Angela Brodie; S E Inkster; W P Zeller; A M DiGeorge; S D Frasier; M W Kilgore; Evan R Simpson
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1994;78(2):1616-21.
1994: Serdar E Bulun; Evan R Simpson
Regulation of aromatase expression in human tissues.
Breast cancer research and treatment 1994;30(1):19-29.
1994: Evan R Simpson; Mala S Mahendroo; J E Nichols; Serdar E Bulun
Aromatase gene expression in adipose tissue: relationship to breast cancer.
International journal of fertility and menopausal studies 1994;39 Suppl 2():75-83.
1993: Y Ito; C R Fisher; Felix A Conte; Melvin M Grumbach; Evan R Simpson
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11673-7.
1993: Serdar E Bulun; I M Rosenthal; Angela Brodie; S E Inkster; W P Zeller; A M DiGeorge; S D Frasier; M W Kilgore; Evan R Simpson
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1993;77(6):1616-21.
1993: B Amarneh; C Jo Corbin; Julian A Peterson; Evan R Simpson; S Graham-Lorence
Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis.
Molecular endocrinology (Baltimore, Md.) 1993;7(12):1617-24.
1993: Serdar E Bulun; T M Price; J Aitken; Mala S Mahendroo; Evan R Simpson
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
The Journal of clinical endocrinology and metabolism 1993;77(6):1622-8.
1993: Margaret M Hinshelwood; C Jo Corbin; P C Tsang; Evan R Simpson
Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450.
Endocrinology 1993;133(5):1971-7.
1993: Mala S Mahendroo; Carole R Mendelson; Evan R Simpson
Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.
The Journal of biological chemistry 1993;268(26):19463-70.
1993: M E Lauber; H M Picton; M Begeot; K Momoi; M R Waterman; Evan R Simpson
Regulation of CYP11A gene expression in bovine ovarian granulosa cells in primary culture by cAMP and phorbol esters is conferred by a common cis-acting element.
Molecular and cellular endocrinology 1993;94(2):235-42.
1993: M E Lauber; N Kagawa; M R Waterman; Evan R Simpson
cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture.
Molecular and cellular endocrinology 1993;93(2):227-33.
1993: Serdar E Bulun; Mala S Mahendroo; Evan R Simpson
Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua.
The Journal of clinical endocrinology and metabolism 1993;76(6):1458-63.
1993: Evan R Simpson; Mala S Mahendroo; G D Means; M W Kilgore; C Jo Corbin; Carole R Mendelson
Tissue-specific promoters regulate aromatase cytochrome P450 expression.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):321-30.
1993: M Demeter-Arlotto; William E Rainey; Evan R Simpson
Maintenance and regulation of 17 alpha-hydroxylase expression by bovine thecal cells in primary culture.
Endocrinology 1993;132(3):1353-8.
1993: Evan R Simpson; Mala S Mahendroo; G D Means; M W Kilgore; C Jo Corbin; Carole R Mendelson
Tissue-specific promoters regulate aromatase cytochrome P450 expression.
Clinical chemistry 1993;39(2):317-24.
1993: W H Trzeciak; Jean-Guy LeHoux; M R Waterman; Evan R Simpson
Dexamethasone inhibits corticotropin-induced accumulation of CYP11A and CYP17 messenger RNAs in bovine adrenocortical cells.
Molecular endocrinology (Baltimore, Md.) 1993;7(2):206-13.
1992: Edwin D Lephart; Evan R Simpson; Michael J McPhaul; M W Kilgore; Jean D Wilson; Sergio R Ojeda
Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat.
Brain research. Molecular brain research 1992;16(3-4):187-92.
1992: K Momoi; M R Waterman; Evan R Simpson; Uli Zanger
3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1682-90.
1992: T Yanase; M R Waterman; M Zachmann; J S Winter; Evan R Simpson; M Kagimoto
Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency.
Biochimica et biophysica acta 1992;1139(4):275-9.
1992: Edwin D Lephart; Evan R Simpson; Michael J McPhaul
Ovarian aromatase cytochrome P-450 mRNA levels correlate with enzyme activity and serum estradiol levels in anestrous, pregnant and lactating rats.
Molecular and cellular endocrinology 1992;85(3):205-14.
1992: Edwin D Lephart; K J Doody; Michael J McPhaul; Evan R Simpson
Inverse relationship between ovarian aromatase cytochrome P450 and 5 alpha-reductase enzyme activities and mRNA levels during the estrous cycle in the rat.
The Journal of steroid biochemistry and molecular biology 1992;42(5):439-47.
1992: T Imai; T Yanase; M R Waterman; Evan R Simpson; J J Pratt
Canadian Mennonites and individuals residing in the Friesland region of The Netherlands share the same molecular basis of 17 alpha-hydroxylase deficiency.
Human genetics 1992;89(1):95-6.
1992: T Price; J Aitken; Evan R Simpson
Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification.
The Journal of clinical endocrinology and metabolism 1992;74(4):879-83.
1992: R Ahlgren; T Yanase; Evan R Simpson; J S Winter; M R Waterman
Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency.
The Journal of clinical endocrinology and metabolism 1992;74(3):667-72.
1992: E D Lephart; Evan R Simpson; S R Ojeda
Effects of Cyclic AMP and Andre-gens on in vitro Brain Aromatase Enzyme Activity During Prenatal Development in the Rat.
Journal of neuroendocrinology 1992;4(1):29-36.
1992: M W Kilgore; G D Means; Carole R Mendelson; Evan R Simpson
Alternative promotion of aromatase P-450 expression in the human placenta.
Molecular and cellular endocrinology 1992;83(1):R9-16.
1991: M K Sanghera; Evan R Simpson; Michael J McPhaul; G Kozlowski; Alan J Conley; Edwin D Lephart
Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodies.
Endocrinology 1991;129(6):2834-44.
1991: G D Means; M W Kilgore; Mala S Mahendroo; Carole R Mendelson; Evan R Simpson
Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):2005-13.
1991: A Biason; Franco Mantero; Carla Scaroni; Evan R Simpson; M R Waterman
Deletion within the CYP17 gene together with insertion of foreign DNA is the cause of combined complete 17 alpha-hydroxylase/17,20-lyase deficiency in an Italian patient.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):2037-45.
1991: S Graham-Lorence; M W Khalil; M C Lorence; Carole R Mendelson; Evan R Simpson
Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis.
The Journal of biological chemistry 1991;266(18):11939-46.
1991: Uli Zanger; J Lund; Evan R Simpson; M R Waterman
Activation of transcription in cell-free extracts by a novel cAMP-responsive sequence from the bovine CYP17 gene.
The Journal of biological chemistry 1991;266(18):11417-20.
1991: Mala S Mahendroo; G D Means; Carole R Mendelson; Evan R Simpson
Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta.
The Journal of biological chemistry 1991;266(17):11276-81.
1991: M E Lauber; T Bengtson; M R Waterman; Evan R Simpson
Regulation of CYP11A (P450SCC) and CYP17 (P450(17) alpha) gene expression in bovine luteal cells in primary culture.
The Journal of biological chemistry 1991;266(17):11170-5.
1991: Edwin D Lephart; Evan R Simpson; W H Trzeciak
Rat adrenal 5 alpha-reductase mRNA content and enzyme activity are sex hormone dependent.
Journal of molecular endocrinology 1991;6(2):163-70.
1991: K J Doody; Edwin D Lephart; D Stirling; M C Lorence; Ronald R Magness; Michael J McPhaul; Evan R Simpson
Expression of mRNA species encoding steroidogenic enzymes in the rat ovary.
Journal of molecular endocrinology 1991;6(2):153-62.
1991: T Yanase; Evan R Simpson; M R Waterman
17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition.
Endocrine reviews 1991;12(1):91-108.
1991: D Stirling; M R Waterman; Evan R Simpson
Expression of mRNA encoding basic fibroblast growth factor (bFGF) in bovine corpora lutea and cultured luteal cells.
Journal of reproduction and fertility 1991;91(1):1-8.
1991: M E Lauber; M R Waterman; Evan R Simpson
Expression of genes encoding steroidogenic enzymes in the bovine corpus luteum.
Journal of reproduction and fertility. Supplement 1991;43():57-64.
1990: Edwin D Lephart; A S Andersson; Evan R Simpson
Expression of neural 5 alpha-reductase messenger ribonucleic acid: comparison to 5 alpha-reductase activity during prenatal development in the rat.
Endocrinology 1990;127(3):1121-8.
1990: J M McAllister; J I Mason; W Byrd; J M Trant; M R Waterman; Evan R Simpson
Proliferating human granulosa-lutein cells in long term monolayer culture: expression of aromatase, cholesterol side-chain cleavage, and 3 beta-hydroxysteroid dehydrogenase.
The Journal of clinical endocrinology and metabolism 1990;71(1):26-33.
1990: T Yanase; D Sanders; A Shibata; N Matsui; Evan R Simpson; M R Waterman
Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene.
The Journal of clinical endocrinology and metabolism 1990;70(5):1325-9.
1990: Evan R Simpson; J Lund; R Ahlgren; M R Waterman
Regulation by cyclic AMP of the genes encoding steroidogenic enzymes: when the light finally shines...
Molecular and cellular endocrinology 1990;70(2):C25-8.
1990: K J Doody; M C Lorence; J I Mason; Evan R Simpson
Expression of messenger ribonucleic acid species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle.
The Journal of clinical endocrinology and metabolism 1990;70(4):1041-5.
1990: R Ahlgren; Evan R Simpson; M R Waterman; J Lund
Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.
The Journal of biological chemistry 1990;265(6):3313-9.
1990: J Lund; R Ahlgren; D H Wu; M Kagimoto; Evan R Simpson; M R Waterman
Transcriptional regulation of the bovine CYP17 (P-450(17)alpha) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE).
The Journal of biological chemistry 1990;265(6):3304-12.
1990: M R Waterman; J Lund; R Ahlgren; D Wu; Evan R Simpson
Regulation of steroid hydroxylase gene expression and steroid hormone biosynthesis.
Biochemical Society transactions 1990;18(1):26-8.
1990: David Stirling; Ronald R Magness; R Stone; M R Waterman; Evan R Simpson
Angiotensin II inhibits luteinizing hormone-stimulated cholesterol side chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture.
The Journal of biological chemistry 1990;265(1):5-8.
1990: M R Waterman; Evan R Simpson
Steroidogenic capacity in the adrenal cortex and its regulation.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1990;34():359-81.
1990: Evan R Simpson; T Price; J Aitken; Mala S Mahendroo; G Means; M Kilgore
The aromatase enzyme: from cloning to cancer.
Princess Takamatsu symposia 1990;21():75-87.
1990: Carole R Mendelson; G D Means; Mala S Mahendroo; C Jo Corbin; Michael P Steinkampf; S Graham-Lorence; Evan R Simpson
Use of molecular probes to study regulation of aromatase cytochrome P-450.
Biology of reproduction 1990;42(1):1-10.
1989: G D Means; Mala S Mahendroo; C Jo Corbin; J Michael Mathis; F E Powell; Carole R Mendelson; Evan R Simpson
Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis.
The Journal of biological chemistry 1989;264(32):19385-91.
1989: T Yanase; M Kagimoto; S Suzuki; K Hashiba; Evan R Simpson; M R Waterman
Deletion of a phenylalanine in the N-terminal region of human cytochrome P-450(17 alpha) results in partial combined 17 alpha-hydroxylase/17,20-lyase deficiency.
The Journal of biological chemistry 1989;264(30):18076-82.
1989: J M McAllister; J F Kerin; J M Trant; Ronald W Estabrook; J I Mason; M R Waterman; Evan R Simpson
Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture.
Endocrinology 1989;125(4):1959-66.
1989: K Kagimoto; M R Waterman; M Kagimoto; P Ferreira; Evan R Simpson; J S Winter
Identification of a common molecular basis for combined 17 alpha-hydroxylase/17,20-lyase deficiency in two Mennonite families.
Human genetics 1989;82(3):285-6.
1989: Raman Bhasker; B S Adler; A Dee; M E John; M Kagimoto; M X Zuber; R Ahlgren; X D Wang; Evan R Simpson; M R Waterman
Structural characterization of the bovine CYP17 (17 alpha-hydroxylase) gene.
Archives of biochemistry and biophysics 1989;271(2):479-87.
1989: V Boggaram; M E John; Evan R Simpson; M R Waterman
Effect of ACTH on the stability of mRNAs encoding bovine adrenocortical P-450scc, P-45011 beta, P-45017 alpha, P-450C21 and adrenodoxin.
Biochemical and biophysical research communications 1989;160(3):1227-32.
1989: Evan R Simpson; J C Merrill; A J Hollub; S Graham-Lorence; Carole R Mendelson
Regulation of estrogen biosynthesis by human adipose cells.
Endocrine reviews 1989;10(2):136-48.
1989: J Michael Mathis; W H Houser; E Bresnick; J A Cidlowski; Ronald Hines; Russell A Prough; Evan R Simpson
Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: receptor binding within intron I.
Archives of biochemistry and biophysics 1989;269(1):93-105.
1989: J Lund; J I Mason; Evan R Simpson; M R Waterman
Developmental regulation of P-45017 alpha gene expression in fetal bovine adrenal.
Endocrine research 1989;15(1-2):17-29.
1989: M R Waterman; J I Mason; M X Zuber; M C Lorence; B J Clark; J M Trant; H J Barnes; Evan R Simpson; Ronald W Estabrook
Expression of P-450 enzyme activities in heterologous cells by transfection.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():155-63.
1988: C Jo Corbin; S Graham-Lorence; Michael J McPhaul; J I Mason; Carole R Mendelson; Evan R Simpson
Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8948-52.
1988: Michael J McPhaul; J F Noble; Evan R Simpson; Carole R Mendelson; Jean D Wilson
The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen.
The Journal of biological chemistry 1988;263(31):16358-63.
1988: T Yanase; M Kagimoto; N Matsui; Evan R Simpson; M R Waterman
Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17 alpha-hydroxylase cytochrome P-450.
Molecular and cellular endocrinology 1988;59(3):249-53.
1988: Michael P Steinkampf; Carole R Mendelson; Evan R Simpson
Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells.
Molecular and cellular endocrinology 1988;59(1-2):93-9.
1988: Raymond Rodgers; M R Waterman; Evan R Simpson; Ronald R Magness
Immunoblot analysis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in corpora lutea of cyclic and late-pregnant sheep.
Journal of reproduction and fertility 1988;83(2):843-50.
1988: Raymond Rodgers; M D Mitchell; Evan R Simpson
Secretion of progesterone and prostaglandins by cells of bovine corpora lutea from three stages of the luteal phase.
The Journal of endocrinology 1988;118(1):121-6.
1988: M Kagimoto; K Kagimoto; Evan R Simpson; M R Waterman
Transcription of the bovine adrenodoxin gene produces two species of mRNA of which only one is translated into adrenodoxin.
The Journal of biological chemistry 1988;263(18):8925-8.
1988: M Kagimoto; J S Winter; K Kagimoto; Evan R Simpson; M R Waterman
Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):564-70.
1988: M X Zuber; J I Mason; Evan R Simpson; M R Waterman
Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: incorporation of a steroidogenic pathway into nonsteroidogenic cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):699-703.
1988: M R Waterman; J I Mason; Evan R Simpson
Regulation of steroid hydroxylase gene expression.
Progress in clinical and biological research 1988;274():543-55.
1988: Evan R Simpson; M R Waterman
Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH.
Annual review of physiology 1988;50():427-40.
1987: W H Trzeciak; T Duda; M R Waterman; Evan R Simpson
Tetradecanoyl phorbol acetate suppresses follicle-stimulating hormone-induced synthesis of the cholesterol side-chain cleavage enzyme complex in rat ovarian granulosa cells.
The Journal of biological chemistry 1987;262(31):15246-50.
1987: Evan R Simpson; C T Evans; C Jo Corbin; F E Powell; D B Ledesma; Carole R Mendelson
Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM).
Molecular and cellular endocrinology 1987;52(3):267-72.
1987: Carole R Mendelson; Evan R Simpson
Regulation of estrogen biosynthesis by human adipose cells in vitro.
Molecular and cellular endocrinology 1987;52(3):169-76.
1987: W H Trzeciak; T Duda; M R Waterman; Evan R Simpson
Effects of epidermal growth factor on the synthesis of the cholesterol side-chain cleavage enzyme complex in rat ovarian granulosa cells in primary culture.
Molecular and cellular endocrinology 1987;52(1-2):43-50.
1987: M P Steinkampf; Carole R Mendelson; Evan R Simpson
Regulation by follicle-stimulating hormone of the synthesis of aromatase cytochrome P-450 in human granulosa cells.
Molecular endocrinology (Baltimore, Md.) 1987;1(7):465-71.
1987: Carole R Mendelson; J C Merrill; M P Steinkampf; Evan R Simpson
Regulation of the synthesis of aromatase cytochrome P-450 in human adipose stromal and ovarian granulosa cells.
Steroids 1987;50(1-3):51-9.
1987: Evan R Simpson; C T Evans; Carole R Mendelson
Aromatase cytochrome P-450: preparation of polyclonal and monoclonal antibodies and a cDNA insert.
Steroids 1987;50(1-3):3-9.
1987: C T Evans; C Jo Corbin; C T Saunders; J C Merrill; Evan R Simpson; Carole R Mendelson
Regulation of estrogen biosynthesis in human adipose stromal cells. Effects of dibutyryl cyclic AMP, epidermal growth factor, and phorbol esters on the synthesis of aromatase cytochrome P-450.
The Journal of biological chemistry 1987;262(14):6914-20.
1987: K D Bradshaw; M R Waterman; R T Couch; Evan R Simpson; M X Zuber
Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency.
Molecular endocrinology (Baltimore, Md.) 1987;1(5):348-54.
1987: Raymond Rodgers; M R Waterman; Evan R Simpson
Levels of messenger ribonucleic acid encoding cholesterol side-chain cleavage cytochrome P-450, 17 alpha-hydroxylase cytochrome P-450, adrenodoxin, and low density lipoprotein receptor in bovine follicles and corpora lutea throughout the ovarian cycle.
Molecular endocrinology (Baltimore, Md.) 1987;1(3):274-9.
1987: Raymond Rodgers; J I Mason; M R Waterman; Evan R Simpson
Regulation of the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the bovine ovary in vivo and in vitro.
Molecular endocrinology (Baltimore, Md.) 1987;1(2):172-80.
1987: Evan R Simpson; J I Mason; M E John; M X Zuber; Raymond Rodgers; M R Waterman
Regulation of the biosynthesis of steroidogenic enzymes.
Journal of steroid biochemistry 1987;27(4-6):801-5.
1987: Carole R Mendelson; C T Evans; Evan R Simpson
Regulation of aromatase in estrogen-producing cells.
Journal of steroid biochemistry 1987;27(4-6):753-7.
1986: C T Evans; D B Ledesma; T Z Schulz; Evan R Simpson; Carole R Mendelson
Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6387-91.
1986: M E John; M C John; V Boggaram; Evan R Simpson; M R Waterman
Transcriptional regulation of steroid hydroxylase genes by corticotropin.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4715-9.
1986: M E John; T Okamura; A Dee; B Adler; M C John; P C White; Evan R Simpson; M R Waterman
Bovine steroid 21-hydroxylase: regulation of biosynthesis.
Biochemistry 1986;25(10):2846-53.
1986: J Michael Mathis; Russell A Prough; Ronald Hines; E Bresnick; Evan R Simpson
Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes.
Archives of biochemistry and biophysics 1986;246(1):439-48.
1986: M X Zuber; M E John; T Okamura; Evan R Simpson; M R Waterman
Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence.
The Journal of biological chemistry 1986;261(5):2475-82.
1986: M R Waterman; J I Mason; M X Zuber; M E John; Raymond Rodgers; Evan R Simpson
Control of gene expression of adrenal steroid hydroxylases and related enzymes.
Endocrine research 1986;12(4):393-408.
1985: T Okamura; M E John; M X Zuber; Evan R Simpson; M R Waterman
Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin: evidence for a previously unidentified COOH-terminal peptide.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5705-9.
1985: M E John; M C John; Evan R Simpson; M R Waterman
Regulation of cytochrome P-45011 beta gene expression by adrenocorticotropin.
The Journal of biological chemistry 1985;260(9):5760-7.
1984: M E John; M C John; P Ashley; R J MacDonald; Evan R Simpson; M R Waterman
Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(18):5628-32.
1984: M E John; Evan R Simpson; V Boggaram; M R Waterman
Molecular cloning of steroid hydroxylases.
Endocrine research 1984;10(3-4):319-33.