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Robert Simpson
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47
Peters, Timothy
41
Raja, Kishor
30
McKie, Andrew
15
Latunde-Dada, Gladys
14
Laftah, Abas
7
Wrigglesworth, JM
5
Srai, Kaila
5
Vulpe, Christopher
5
Anderson, Gregory
5
Bjarnason, Ingvar
5
Farzaneh, Farzin
4
Beaumont, Nick
4
Bomford, Adrian
4
Bahram, Seiamak
4
Jacob, Molly
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All Publications
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2009: Bansal Sukhvinder S; Halket John M; Fusova Jane; Bomford Adrian; Simpson Robert J; Vasavda Nisha; Thein Swee Lay; Hider Robert C
Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(11):1531-42.
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2009: Laftah Abas H; Latunde-Dada Gladys O; Fakih Sarah; Hider Robert C; Simpson Robert J; McKie Andrew T
Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1).
The British journal of nutrition 2009;101(8):1150-6.
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2009: Lambe Teresa; Simpson Robert J; Dawson Sara; Bouriez-Jones Tiphaine; Crockford Tanya L; Lepherd Michelle; Latunde-Dada Gladys O; Robinson Hannah; Raja Kishor B; Campagna Dean R; Villarreal Guadalupe; Ellory J Clive; Goodnow Christopher C; Fleming Mark D; McKie Andrew T; Cornall Richard J
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Blood 2009;113(8):1805-8.
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2009: Bansal Sukhvinder S; Halket John M; Bomford Adrian; Simpson Robert J; Vasavda Nisha; Thein Swee Lay; Hider Robert C
Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry.
Analytical biochemistry 2009;384(2):245-53.
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2008: Wyman Steven; Simpson Robert J; McKie Andrew T; Sharp Paul A
Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro.
FEBS letters 2008;582(13):1901-6.
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2008: Latunde-Dada Gladys O; Simpson Robert J; McKie Andrew T
Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells.
The Journal of nutrition 2008;138(6):991-5.
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2008: Laftah A H; Simpson R J; Peters T J; Raja K B
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.
Toxicology and applied pharmacology 2008;229(3):273-80.
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2006: Latunde-Dada Gladys O; Takeuchi Ken; Simpson Robert J; McKie Andrew T
Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells.
FEBS letters 2006;580(30):6865-70.
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2006: Li A C Y; Warley A; Thoree V; Simpson R J; McKie A T; Kodjabashia K; Thompson R P H; Powell J J
Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status.
European journal of clinical investigation 2006;36(12):890-8.
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2006: Raja Kishor B; Jafri Shahnaz E; Peters Timothy J; Simpson Robert J
Iron and cadmium uptake by duodenum of hypotransferrinaemic mice.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2006;19(5):547-53.
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2006: Laftah Abas H; Sharma Naveen; Brookes Matthew J; McKie Andrew T; Simpson Robert J; Iqbal Tariq H; Tselepis Chris
Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice.
The Biochemical journal 2006;397(1):61-7.
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2006: Latunde-Dada Gladys O; McKie Andrew T; Simpson Robert J
Animal models with enhanced erythropoiesis and iron absorption.
Biochimica et biophysica acta 2006;1762(4):414-23.
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2006: Latunde-Dada Gladys O; Simpson Robert J; McKie Andrew T
Recent advances in mammalian haem transport.
Trends in biochemical sciences 2006;31(3):182-8.
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2005: Raja Kishor B; O Latunde-Dada Gladys; Peters Timothy J; McKie Andrew T; Simpson Robert J
Role of interleukin-6 in hypoxic regulation of intestinal iron absorption.
British journal of haematology 2005;131(5):656-62.
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2005: Shayeghi Majid; Latunde-Dada Gladys O; Oakhill Jonathan S; Laftah Abas H; Takeuchi Ken; Halliday Neil; Khan Yasmin; Warley Alice; McCann Fiona E; Hider Robert C; Frazer David M; Anderson Gregory J; Vulpe Christopher D; Simpson Robert J; McKie Andrew T
Identification of an intestinal heme transporter.
Cell 2005;122(5):789-801.
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2005: McGregor J A; Shayeghi M; Vulpe C D; Anderson G J; Pietrangelo A; Simpson R J; McKie A T
Impaired iron transport activity of ferroportin 1 in hereditary iron overload.
The Journal of membrane biology 2005;206(1):3-7.
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2005: Laftah A H; Raja K B; Latunde-Dada G O; Vergi T; McKie A T; Simpson R J; Peters T J
Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice.
Annals of hematology 2005;84(3):177-82.
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2005: Takeuchi Ken; Bjarnason Ingvar; Laftah Abas H; Latunde-Dada Gladys O; Simpson Robert J; McKie Andrew T
Expression of iron absorption genes in mouse large intestine.
Scandinavian journal of gastroenterology 2005;40(2):169-77.
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2005: Atanasova Bisera D; Li Andy Cy; Bjarnason Ingvar; Tzatchev Kamen N; Simpson Robert J
Duodenal ascorbate and ferric reductase in human iron deficiency.
The American journal of clinical nutrition 2005;81(1):130-3.
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2004: Latunde-Dada G O; Vulpe C D; Anderson G J; Simpson R J; McKie A T
Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.
Biochimica et biophysica acta 2004;1690(2):169-76.
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2004: Latunde-Dada G O; Shirali S; McKie A T; Simpson R J; Peters T J
Effect of transition metal ions (cobalt and nickel chlorides) on intestinal iron absorption.
European journal of clinical investigation 2004;34(9):626-30.
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2004: Laftah Abas H; Ramesh Bala; Simpson Robert J; Solanky Nita; Bahram Seiamak; Schümann Klaus; Debnam Edward S; Srai Surjit K S
Effect of hepcidin on intestinal iron absorption in mice.
Blood 2004;103(10):3940-4.
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2004: Laftah Abas H; Raja Kishor B; Beaumont Nick; Simpson Robert J; Deacon Allan; Solanky Nita; Srai Surjit Kaila S; Peters Timothy J
The effects of inhibition of haem biosynthesis by griseofulvin on intestinal iron absorption.
Basic & clinical pharmacology & toxicology 2004;94(4):161-8.
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2004: Atanasova Bisera; Mudway Ian S; Laftah Abas H; Latunde-Dada Gladys O; McKie Andrew T; Peters Timothy J; Tzatchev Kamen N; Simpson Robert J
Duodenal ascorbate levels are changed in mice with altered iron metabolism.
The Journal of nutrition 2004;134(3):501-5.
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2004: McGregor Johanne; McKie Andrew T; Simpson Robert J
Of mice and men: genetic determinants of iron status.
The Proceedings of the Nutrition Society 2004;63(1):11-20.
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2003: Laftah Abas H; Simpson Robert J; Beaumont Nick; Bahram Seiamak; Schümann Klaus; Srai S Kaila S
Hypoxic response of iron absorption is not affected by the Hfe gene knock-out in mice.
British journal of haematology 2003;123(1):170-2.
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2003: Laftah Abas H; Raja Kishor; Simpson Robert J; Peters Timothy J
Effect of Tin-mesoporphyrin, an inhibitor of haem catabolism, on intestinal iron absorption.
British journal of haematology 2003;122(2):298-304.
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2003: Simpson R J; Debnam E; Beaumont N; Bahram S; Schümann K; Srai S K S
Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding.
Gut 2003;52(4):510-3.
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2003: Simpson Robert J; Debnam Edward S; Laftah Abas H; Solanky Nita; Beaumont Nick; Bahram Seiamak; Schümann Klaus; Srai S Kaila S
Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out.
Blood 2003;101(8):3316-8.
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2003: Miret Silvia; Simpson Robert J; McKie Andrew T
Physiology and molecular biology of dietary iron absorption.
Annual review of nutrition 2003;23():283-301.
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2002: Latunde-Dada G O; Van der Westhuizen J; Vulpe C D; Anderson G J; Simpson R J; McKie A T
Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism.
Blood cells, molecules & diseases 2002;29(3):356-60.
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2002: Cremonesi Piero; Acebron Alvaro; Raja Kishor B; Simpson Robert J
Iron absorption: biochemical and molecular insights into the importance of iron species for intestinal uptake.
Pharmacology & toxicology 2002;91(3):97-102.
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2002: McKie A T; Latunde-Dada G O; Miret S; McGregor J A; Anderson G J; Vulpe C D; Wrigglesworth J M; Simpson R J
Molecular evidence for the role of a ferric reductase in iron transport.
Biochemical Society transactions 2002;30(4):722-4.
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2002: Sigthorsson Gudmundur; Simpson Robert J; Walley Matthew; Anthony Andrew; Foster Russell; Hotz-Behoftsitz Christoph; Palizban Abbas; Pombo Joaquim; Watts Jo; Morham Scott G; Bjarnason Ingvar
COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.
Gastroenterology 2002;122(7):1913-23.
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2002: Jacob Molly; Bjarnason Ingvar; Simpson Robert J
Effects of indomethacin on energy metabolism in rat jejunal tissue in vivo.
Clinical science (London, England : 1979) 2002;102(5):541-6.
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2001: Jacob M; Bjarnason I; Rafi S; Wrigglesworth J; Simpson R J
A study of the effects of indometacin on liver mitochondria from rats, mice and humans.
Alimentary pharmacology & therapeutics 2001;15(11):1837-42.
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2001: McKie A T; Barrow D; Latunde-Dada G O; Rolfs A; Sager G; Mudaly E; Mudaly M; Richardson C; Barlow D; Bomford A; Peters T J; Raja K B; Shirali S; Hediger M A; Farzaneh F; Simpson R J
An iron-regulated ferric reductase associated with the absorption of dietary iron.
Science (New York, N.Y.) 2001;291(5509):1755-9.
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2000: Raja K B; Jafri S E; Dickson D; Acebròn A; Cremonesi P; Fossati G; Simpson R J
Involvement of iron (ferric) reduction in the iron absorption mechanism of a trivalent iron-protein complex (iron protein succinylate).
Pharmacology & toxicology 2000;87(3):108-15.
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2000: Somasundaram S; Sigthorsson G; Simpson R J; Watts J; Jacob M; Tavares I A; Rafi S; Roseth A; Foster R; Price A B; Wrigglesworth J M; Bjarnason I
Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat.
Alimentary pharmacology & therapeutics 2000;14(5):639-50.
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2000: McKie A T; Marciani P; Rolfs A; Brennan K; Wehr K; Barrow D; Miret S; Bomford A; Peters T J; Farzaneh F; Hediger M A; Hentze M W; Simpson R J
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.
Molecular cell 2000;5(2):299-309.
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1999: Raja K B; Pountney D J; Simpson R J; Peters T J
Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice.
Blood 1999;94(9):3185-92.
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1999: Pountney D J; Konijn A M; McKie A T; Peters T J; Raja K B; Salisbury J R; Simpson R J
Iron proteins of duodenal enterocytes isolated from mice with genetically and experimentally altered iron metabolism.
British journal of haematology 1999;105(4):1066-73.
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1999: Pountney D J; Raja K B; Simpson R J; Wrigglesworth J M
The ferric-reducing activity of duodenal brush-border membrane vesicles is associated with a b-type haem.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1999;12(1):53-62.
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1998: Mahmud T; Somasundaram S; Sigthorsson G; Simpson R J; Rafi S; Foster R; Tavares I A; Roseth A; Hutt A J; Jacob M; Pacy J; Scott D L; Wrigglesworth J M; Bjarnason I
Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat.
Gut 1998;43(6):775-82.
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1998: Simpson R J; Jafri S E
Iron and proton uptake by mouse duodenum.
Biochemical Society transactions 1998;26(4):S388.
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1998: Simpson R J; Mohamad-Ghaffer A; Khan R
Glutathione and duodenal reduction and absorption of iron.
Biochemical Society transactions 1998;26(4):S352.
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1998: Jacob M; Bjarnason I; Simpson R J
In vitro evidence for mitochondrial effects of indomethacin.
Biochemical Society transactions 1998;26(4):S315.
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1998: McKie A T; Wehr K; Simpson R J; Peters T J; Hentze M W; Farzaneh F
Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption.
Biochemical Society transactions 1998;26(3):S264.
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1998: Laftah A H; Raja K B; Simpson R J; Peters T J
delta-Aminolevulenic acid (ALA) and the control of intestinal iron absorption.
Biochemical Society transactions 1998;26(3):S205.
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1998: Jacob M; Bjarnason I; Simpson R J
Effects of indomethacin on mitochondrial oxygen uptake in intestine.
Biochemical Society transactions 1998;26(2):S162.
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1998: Jacob M; Bjarnason I; Simpson R J
Effects of indomethacin on mitochondrial ATP synthesis.
Biochemical Society transactions 1998;26(2):S161.
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1997: Simpson R J; Deenmamode J; McKie A T; Raja K B; Salisbury J R; Iancu T C; Peters T J
Time-course of iron overload and biochemical, histopathological and ultrastructural evidence of pancreatic damage in hypotransferrinaemic mice.
Clinical science (London, England : 1979) 1997;93(5):453-62.
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1997: Simpson R J; al-Barwani H
Duodenal ferri-reductase is not mediated by ascorbate.
Biochemical Society transactions 1997;25(3):391S.
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1997: Raja K B; Jayasinghe N N; Simpson R J; Peters T J
Nitric oxide: effects on duodenal iron absorption.
Biochemical Society transactions 1997;25(3):390S.
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1997: Laftah A; Raja K B; Simpson R J; Peters T J
Importance of haem biosynthesis in the control of intestinal iron absorption.
Biochemical Society transactions 1997;25(1):58S.
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1997: Raja K B; Maxwell P H; Ratcliffe P J; Salisbury J R; Simpson R J; Peters T J
Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin.
British journal of haematology 1997;96(2):248-53.
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1996: McKie A T; Raja K B; Peters T J; Farzaneh F; Simpson R J
Expression of genes involved in iron metabolism in mouse intestine.
The American journal of physiology 1996;271(5 Pt 1):G772-9.
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1996: McKie A T; Simpson R J; Ghosh S; Peters T J; Farzaneh F
Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.
Clinical science (London, England : 1979) 1996;91(2):213-8.
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1996: Raja K B; Pountney D; Bomford A; Przemioslo R; Sherman D; Simpson R J; Williams R; Peters T J
A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis.
Gut 1996;38(5):765-9.
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1996: Pountney D J; Raja K B; Bottwood M J; Wrigglesworth J M; Simpson R J
Mucosal surface ferricyanide reductase activity in mouse duodenum.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1996;9(1):15-20.
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1995: Rabie A; Simpson R J; Bomford A; Cunninghame-Graham D; Peters T J
Relationship between duodenal cytosolic aconitase activity and iron status in the mouse.
Biochimica et biophysica acta 1995;1245(3):414-20.
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1995: Raja K B; Duane P; Snape S D; Simpson R J; Papasavvas G; Peters T J
In vitro duodenal iron uptake and serum and mucosal iron protein levels, with special reference to rheumatoid arthritis.
British journal of rheumatology 1995;34(11):1041-7.
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1995: Raja K B; Gerard B; McKie A T; Simpson R J; Peters T J; Grandchamp B; Beaumont C
Duodenal expression of NF-E2 in mouse models of altered iron metabolism.
British journal of haematology 1995;91(2):483-9.
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1995: Lazouras K; Pountney D; Simpson R J
Inhibition of duodenal mucosal ferricyanide reductase.
Biochemical Society transactions 1995;23(2):338S.
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1995: Raja K B; Gerard B; McKie A; Beaumont C; Simpson R J; Grandchamp B; Peters T J
Duodenal expression of NF-E2 in mouse models of altered iron metabolism.
Biochemical Society transactions 1995;23(2):326S.
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1995: Raja K B; Simpson R J; Peters T J
Assessment of intestinal blood-flux by laser Doppler fluxmetry in mice with altered intestinal iron absorption.
British journal of haematology 1995;89(4):874-9.
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1995: Pountney D J; Shergill J K; Simpson R J; Wrigglesworth J M
EPR and visible spectroscopic analysis of a duodenal b-type cytochrome implicated in the process of intestinal iron absorption.
Biochemical Society transactions 1995;23(1):140S.
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1995: Raja K B; Simpson R J; Peters T J
Plasma clearance of transferrin in control and hypotransferrinaemic mice: implications for regulation of transferrin turnover.
British journal of haematology 1995;89(1):177-80.
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1994: Pountney D J; Simpson R J; Wrigglesworth J M
Duodenal ferric reductase: purification and characterisation.
Biochemical Society transactions 1994;22(3):284S.
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1994: Mueller S; Simpson R J
Photoreduction of iron at physiological pH: effect of biological buffers.
Biochemical Society transactions 1994;22(2):93S.
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1994: Raja K B; Simpson R J; Peters T J
Intestinal iron absorption studies in mouse models of iron-overload.
British journal of haematology 1994;86(1):156-62.
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1993: Simpson R J; Konijn A M; Lombard M; Raja K B; Salisbury J R; Peters T J
Tissue iron loading and histopathological changes in hypotransferrinaemic mice.
The Journal of pathology 1993;171(3):237-44.
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1993: Alcorn C J; Simpson R J; Leahy D E; Peters T J
Partition and distribution coefficients of solutes and drugs in brush border membrane vesicles.
Biochemical pharmacology 1993;45(9):1775-82.
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1993: Simpson R J; Rabie A; Peters T J
Cytosolic aconitase activity in mouse small intestine: iron dependence.
Biochemical Society transactions 1993;21(2):205S.
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1993: Pountney D J; Simpson R J
Mucosal surface ferricyanide reductase in mouse duodenum.
Biochemical Society transactions 1993;21(2):204S.
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1992: Simpson R J; Cooper C E; Raja K B; Halliwell B; Evans P J; Aruoma O I; Singh S; Konijn A M
Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice.
Biochimica et biophysica acta 1992;1156(1):19-26.
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1992: Duane P; Raja K B; Simpson R J; Peters T J
Intestinal iron absorption in chronic alcoholics.
Alcohol and alcoholism (Oxford, Oxfordshire) 1992;27(5):539-44.
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1992: Raja K B; Simpson R J; Peters T J
Investigation of a role for reduction in ferric iron uptake by mouse duodenum.
Biochimica et biophysica acta 1992;1135(2):141-6.
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1992: Simpson R J; Raja K B; Shah T
Iron chelate affinity chromatography of brush border membrane proteins.
Biochemical Society transactions 1992;20(2):194S.
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1991: Alcorn C J; Simpson R J; Leahy D; Peters T J
In vitro studies of intestinal drug absorption. Determination of partition and distribution coefficients with brush border membrane vesicles.
Biochemical pharmacology 1991;42(12):2259-64.
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1991: Simpson R J; Lombard M; Raja K B; Thatcher R; Peters T J
Iron absorption by hypotransferrinaemic mice.
British journal of haematology 1991;78(4):565-70.
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1991: Simpson R J; Raja K B; Halliwell B; Evans P J; Aruoma O I; Konijn A M; Peters T J
Iron speciation in hypotransferrinaemic mouse serum.
Biochemical Society transactions 1991;19(3):317S.
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1991: Raja K B; Simpson R J; Peters T J
Ferric iron reduction and uptake by mouse duodenal mucosa.
Biochemical Society transactions 1991;19(3):316S.
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1991: Simpson R J; Raja K B; Peruzzi M; Cremonesi P
Absorption of iron from iron succinyl-protein complexes by mouse small intestine.
The Journal of pharmacy and pharmacology 1991;43(6):388-91.
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1990: Snape S; Simpson R J; Peters T J
Subcellular localization of recently-absorbed iron in mouse duodenal enterocytes: identification of a basolateral membrane iron-binding site.
Cell biochemistry and function 1990;8(2):107-15.
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1989: Raja K B; Simpson R J; Peters T J
Effect of exchange transfusion of reticulocytes on in vitro and in vivo intestinal iron (Fe3+) absorption in mice.
British journal of haematology 1989;73(2):254-9.
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1989: Raja K B; Simpson R J; Peters T J
Membrane potential dependence of Fe(III) uptake by mouse duodenum.
Biochimica et biophysica acta 1989;984(3):262-6.
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1989: Simpson R J; Venkatesan S; Peters T J
Brush border membrane non-esterified fatty acids. Physiological levels and significance for mucosal iron uptake in mouse proximal intestine.
Cell biochemistry and function 1989;7(3):165-71.
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1989: Raja K B; Simpson R J; Gregory H; Peters T J
Effect of orally-administered epidermal growth factor on intestinal iron absorption and mucosal permeability.
Cell biochemistry and function 1989;7(3):157-63.
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1988: Simpson R J; Moore R; Peters T J
Significance of non-esterified fatty acids in iron uptake by intestinal brush-border membrane vesicles.
Biochimica et biophysica acta 1988;941(1):39-47.
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1988: Osterloh K; Snape S; Simpson R J; Grindley H; Peters T J
Subcellular distribution of recently absorbed iron and of transferrin in the mouse duodenal mucosa.
Biochimica et biophysica acta 1988;969(2):166-75.
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1988: Raja K B; Simpson R J; Pippard M J; Peters T J
In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse.
British journal of haematology 1988;68(3):373-8.
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1988: Peters T J; Raja K B; Simpson R J; Snape S
Mechanisms and regulation of intestinal iron absorption.
Annals of the New York Academy of Sciences 1988;526():141-7.
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1987: Osterloh K R; Simpson R J; Snape S; Peters T J
Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia.
Blut 1987;55(5):421-31.
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1986: Raja K B; Pippard M J; Simpson R J; Peters T J
Relationship between erythropoiesis and the enhanced intestinal uptake of ferric iron in hypoxia in the mouse.
British journal of haematology 1986;64(3):587-93.
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1986: Simpson R J; Osterloh K R; Raja K B; Snape S D; Peters T J
Studies on the role of transferrin and endocytosis in the uptake of Fe3+ from Fe-nitrilotriacetate by mouse duodenum.
Biochimica et biophysica acta 1986;884(1):166-71.
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