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Richard Simpson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
68
Moritz, Robert
26
Reid, Gavin
21
Nice, Edouard
17
Ward, LD
17
Burgess, Antony
17
Hammacher, A
17
Ji, Hong
14
Eddes, James
12
Connolly, Lisa
12
Nicola, Nicos
9
Fabri, Louis
8
Dorow, Donna
7
Hilton, Douglas
7
Kapp, Eugene
7
Matthews, JM

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Publications

TOP 3
Mathivanan Suresh; Simpson Richard J
ExoCarta: A compendium of exosomal proteins and RNA.
Mathias Rommel A; Simpson Richard J
Towards understanding epithelial-mesenchymal transition: a proteomics perspective.
Simpson Richard J; Lim Justin We; Moritz Robert L; Mathivanan Suresh
Exosomes: proteomic insights and diagnostic potential.

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All Publications

2009: Mathivanan Suresh; Simpson Richard J
ExoCarta: A compendium of exosomal proteins and RNA.
Proteomics 2009;9(21):4997-5000.
2009: Mathias Rommel A; Simpson Richard J
Towards understanding epithelial-mesenchymal transition: a proteomics perspective.
Biochimica et biophysica acta 2009;1794(9):1325-31.
2009: Simpson Richard J; Lim Justin We; Moritz Robert L; Mathivanan Suresh
Exosomes: proteomic insights and diagnostic potential.
Expert review of proteomics 2009;6(3):267-83.
2009: Mathias Rommel A; Wang Bo; Ji Hong; Kapp Eugene A; Moritz Robert L; Zhu Hong-Jian; Simpson Richard J
Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition.
Journal of proteome research 2009;8(6):2827-37.
2009: Boddey Justin A; Moritz Robert L; Simpson Richard J; Cowman Alan F
Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte.
Traffic (Copenhagen, Denmark) 2009;10(3):285-99.
2009: Greening David W; Glenister Kristen M; Sparrow Rosemary L; Simpson Richard J
Enrichment of human platelet membranes for proteomic analysis.
Methods in molecular biology (Clifton, N.J.) 2009;528():245-58.
2009: Mathias Rommel A; Lim Justin W; Ji Hong; Simpson Richard J
Isolation of extracellular membranous vesicles for proteomic analysis.
Methods in molecular biology (Clifton, N.J.) 2009;528():227-42.
2009: Goode Robert J A; Simpson Richard J
Purification of basolateral integral membrane proteins by cationic colloidal silica-based apical membrane subtraction.
Methods in molecular biology (Clifton, N.J.) 2009;528():177-87.
2008: Simpson Richard J; Jensen Søren S; Lim Justin W E
Proteomic profiling of exosomes: current perspectives.
Proteomics 2008;8(19):4083-99.
2008: Ji Hong; Erfani Nasrollah; Tauro Bow J; Kapp Eugene A; Zhu Hong-Jian; Moritz Robert L; Lim Justin W E; Simpson Richard J
Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Electrophoresis 2008;29(12):2660-71.
2008: Simpson Richard J; Bernhard Oliver K; Greening David W; Moritz Robert L
Proteomics-driven cancer biomarker discovery: looking to the future.
Current opinion in chemical biology 2008;12(1):72-7.
2007: Ji Hong; Moritz Robert L; Kim Yu-Sam; Zhu Hong-Jian; Simpson Richard J
Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics.
Electrophoresis 2007;28(12):1997-2008.
2007: Debrincat Marlyse A; Zhang Jian-Guo; Willson Tracy A; Silke John; Connolly Lisa M; Simpson Richard J; Alexander Warren S; Nicola Nicos A; Kile Benjamin T; Hilton Douglas J
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.
The Journal of biological chemistry 2007;282(7):4728-37.
2006: Catimel Bruno; Layton Meredith; Church Nicole; Ross Janine; Condron Melanie; Faux Maree; Simpson Richard J; Burgess Antony W; Nice Edouard C
In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta-catenin interactions.
Analytical biochemistry 2006;357(2):277-88.
2005: Moritz Robert L; Simpson Richard J
Liquid-based free-flow electrophoresis-reversed-phase HPLC: a proteomic tool.
Nature methods 2005;2(11):863-73.
2005: Moritz Robert L; Clippingdale Andrew B; Kapp Eugene A; Eddes James S; Ji Hong; Gilbert Sam; Connolly Lisa M; Simpson Richard J
Application of 2-D free-flow electrophoresis/RP-HPLC for proteomic analysis of human plasma depleted of multi high-abundance proteins.
Proteomics 2005;5(13):3402-13.
2005: Kapp Eugene A; Schütz Frédéric; Connolly Lisa M; Chakel John A; Meza Jose E; Miller Christine A; Fenyo David; Eng Jimmy K; Adkins Joshua N; Omenn Gilbert S; Simpson Richard J
An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: sensitivity and specificity analysis.
Proteomics 2005;5(13):3475-90.
2005: Hoffmann Peter; Olayioye Monilola A; Moritz Robert L; Lindeman Geoffrey J; Visvader Jane E; Simpson Richard J; Kemp Bruce E
Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Electrophoresis 2005;26(6):1029-37.
2005: Moritz Robert L; Skandarajah Anita R; Ji Hong; Simpson Richard J
Proteomic Analysis of Colorectal Cancer: Prefractionation Strategies Using two-Dimensional Free-Flow Electrophoresis.
Comparative and functional genomics 2005;6(4):236-43.
2004: Moritz Robert L; Ji Hong; Schütz Frédéric; Connolly Lisa M; Kapp Eugene A; Speed Terence P; Simpson Richard J
A proteome strategy for fractionating proteins and peptides using continuous free-flow electrophoresis coupled off-line to reversed-phase high-performance liquid chromatography.
Analytical chemistry 2004;76(16):4811-24.
2004: Olayioye Monilola A; Hoffmann Peter; Pomorski Thomas; Armes Jane; Simpson Richard J; Kemp Bruce E; Lindeman Geoffrey J; Visvader Jane E
The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation.
Cancer research 2004;64(10):3538-44.
2004: Faux Maree C; Ross Janine L; Meeker Clare; Johns Terry; Ji Hong; Simpson Richard J; Layton Meredith J; Burgess Antony W
Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.
Journal of cell science 2004;117(Pt 3):427-39.
2003: Kapp Eugene A; Schütz Frédéric; Reid Gavin E; Eddes James S; Moritz Robert L; O'Hair Richard A J; Speed Terence P; Simpson Richard J
Mining a tandem mass spectrometry database to determine the trends and global factors influencing peptide fragmentation.
Analytical chemistry 2003;75(22):6251-64.
2003: Hodder Anthony N; Drew Damien R; Epa V Chandana; Delorenzi Mauro; Bourgon Richard; Miller Susanne K; Moritz Robert L; Frecklington David F; Simpson Richard J; Speed Terence P; Pike Robert N; Crabb Brendan S
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.
The Journal of biological chemistry 2003;278(48):48169-77.
2003: McColl Bradley K; Baldwin Megan E; Roufail Sally; Freeman Craig; Moritz Robert L; Simpson Richard J; Alitalo Kari; Stacker Steven A; Achen Marc G
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
The Journal of experimental medicine 2003;198(6):863-8.
2002: Varghese J N; Moritz R L; Lou M-Z; Van Donkelaar A; Ji H; Ivancic N; Branson K M; Hall N E; Simpson R J
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15959-64.
2002: Eddes James S; Kapp Eugene A; Frecklington David F; Connolly Lisa M; Layton Meredith J; Moritz Robert L; Simpson Richard J
CHOMPER: a bioinformatic tool for rapid validation of tandem mass spectrometry search results associated with high-throughput proteomic strategies.
Proteomics 2002;2(9):1097-103.
2002: Elso Colleen; Toohey Brendan; Reid Gavin E; Poetter Karl; Simpson Richard J; Foote Simon J
Mutation detection using mass spectrometric separation of tiny oligonucleotide fragments.
Genome research 2002;12(9):1428-33.
2002: Akbarzadeh Shiva; Ji Hong; Frecklington David; Marmy-Conus Nelly; Mok Yee-Foong; Bowes Leanne; Devereux Lisa; Linsenmeyer Martha; Simpson Richard J; Dorow Donna S
Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking.
The Journal of biological chemistry 2002;277(39):36280-7.
2002: Krebs Danielle L; Uren Rachel T; Metcalf Donald; Rakar Steven; Zhang Jian-Guo; Starr Robyn; De Souza David P; Hanzinikolas Kathy; Eyles Jo; Connolly Lisa M; Simpson Richard J; Nicola Nicos A; Nicholson Sandra E; Baca Manuel; Hilton Douglas J; Alexander Warren S
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Molecular and cellular biology 2002;22(13):4567-78.
2002: Verhagen Anne M; Silke John; Ekert Paul G; Pakusch Miha; Kaufmann Hitto; Connolly Lisa M; Day Catherine L; Tikoo Anjali; Burke Richard; Wrobel Carolyn; Moritz Robert L; Simpson Richard J; Vaux David L
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
The Journal of biological chemistry 2002;277(1):445-54.
2001: Hoffmann P; Ji H; Moritz R L; Connolly L M; Frecklington D F; Layton M J; Eddes J S; Simpson R J
Continuous free-flow electrophoresis separation of cytosolic proteins from the human colon carcinoma cell line LIM 1215: a non two-dimensional gel electrophoresis-based proteome analysis strategy.
Proteomics 2001;1(7):807-18.
2001: Moritz R L; Hall N E; Connolly L M; Simpson R J
Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.
The Journal of biological chemistry 2001;276(11):8244-53.
2000: Pouliot N; Connolly L M; Moritz R L; Simpson R J; Burgess A W
Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation.
Experimental cell research 2000;261(2):360-71.
2000: Verhagen A M; Ekert P G; Pakusch M; Silke J; Connolly L M; Reid G E; Moritz R L; Simpson R J; Vaux D L
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Cell 2000;102(1):43-53.
2000: Simpson R J; Connolly L M; Eddes J S; Pereira J J; Moritz R L; Reid G E
Proteomic analysis of the human colon carcinoma cell line (LIM 1215): development of a membrane protein database.
Electrophoresis 2000;21(9):1707-32.
2000: Matthews J M; Norton R S; Hammacher A; Simpson R J
The single mutation Phe173 --> Ala induces a molten globule-like state in murine interleukin-6.
Biochemistry 2000;39(8):1942-50.
2000: Hammacher A; Wijdenes J; Hilton D J; Nicola N A; Simpson R J; Layton J E
Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.
The Biochemical journal 2000;345 Pt 1():25-32.
1999: Stacker S A; Stenvers K; Caesar C; Vitali A; Domagala T; Nice E; Roufail S; Simpson R J; Moritz R; Karpanen T; Alitalo K; Achen M G
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
The Journal of biological chemistry 1999;274(45):32127-36.
1999: Cole A R; Hall N E; Treutlein H R; Eddes J S; Reid G E; Moritz R L; Simpson R J
Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.
The Journal of biological chemistry 1999;274(11):7207-15.
1999: Zhang J G; Farley A; Nicholson S E; Willson T A; Zugaro L M; Simpson R J; Moritz R L; Cary D; Richardson R; Hausmann G; Kile B J; Kent S B; Alexander W S; Metcalf D; Hilton D J; Nicola N A; Baca M
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2071-6.
1999: Moritz R L; Ward L D; Tu G F; Fabri L J; Ji H; Yasukawa K; Simpson R J
The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.
Growth factors (Chur, Switzerland) 1999;16(4):265-78.
1998: Rasmussen R K; Rusak J; Price G; Robinson P J; Simpson R J; Dorow D S
Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid.
The Biochemical journal 1998;335 ( Pt 1)():119-24.
1998: Hammacher A; Richardson R T; Layton J E; Smith D K; Angus L J; Hilton D J; Nicola N A; Wijdenes J; Simpson R J
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.
The Journal of biological chemistry 1998;273(35):22701-7.
1998: Matthews J M; Hammacher A; Howlett G J; Simpson R J
Physicochemical characterization of an antagonistic human interleukin-6 dimer.
Biochemistry 1998;37(30):10671-80.
1998: Reid G E; Rasmussen R K; Dorow D S; Simpson R J
Capillary column chromatography improves sample preparation for mass spectrometric analysis: complete characterization of human alpha-enolase from two-dimensional gels following in situ proteolytic digestion.
Electrophoresis 1998;19(6):946-55.
1998: Zugaro L M; Reid G E; Ji H; Eddes J S; Murphy A C; Burgess A W; Simpson R J
Characterization of rat brain stathmin isoforms by two-dimensional gel electrophoresis-matrix assisted laser desorption/ionization and electrospray ionization-ion trap mass spectrometry.
Electrophoresis 1998;19(5):867-76.
1998: Rasmussen R K; Ji H; Eddes J S; Zugaro L M; Reid G E; Simpson R J; Dorow D S
Two-dimensional gel database of human breast carcinoma cell expressed proteins: an update.
Electrophoresis 1998;19(5):818-25.
1998: Rasmussen R K; Ji H; Eddes J S; Moritz R L; Reid G E; Simpson R J; Dorow D S
Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins.
Electrophoresis 1998;19(5):809-17.
1998: Zhang J G; Zhang Y; Owczarek C M; Ward L D; Moritz R L; Simpson R J; Yasukawa K; Nicola N A
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma.
The Journal of biological chemistry 1998;273(17):10798-805.
1997: Hammacher A; Reid G E; Moritz R L; Simpson R J
Identification and characterization of recombinant murine interleukin-6 with a C-terminal pentapeptide extension using capillary reversed phase HPLC-MS and edman degradation.
Biomedical chromatography : BMC 1997;11(6):337-42.
1997: Tong D; Moritz R L; Eddes J S; Reid G E; Rasmussen R K; Dorow D S; Simpson R J
Fabrication of stable packed capillary reversed-phase columns for protein structural analysis.
Journal of protein chemistry 1997;16(5):425-31.
1997: Matthews J M; Ward L D; Hammacher A; Norton R S; Simpson R J
Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.
Biochemistry 1997;36(20):6187-96.
1997: Simpson R J; Hammacher A; Smith D K; Matthews J M; Ward L D
Interleukin-6: structure-function relationships.
Protein science : a publication of the Protein Society 1997;6(5):929-55.
1997: Zhang J G; Hilton D J; Willson T A; McFarlane C; Roberts B A; Moritz R L; Simpson R J; Alexander W S; Metcalf D; Nicola N A
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.
The Journal of biological chemistry 1997;272(14):9474-80.
1997: Ji H; Moritz R L; Reid G E; Ritter G; Catimel B; Nice E; Heath J K; White S J; Welt S; Old L J; Burgess A W; Simpson R J
Electrophoretic analysis of the novel antigen for the gastrointestinal-specific monoclonal antibody, A33.
Electrophoresis 1997;18(3-4):614-21.
1997: Ji H; Reid G E; Moritz R L; Eddes J S; Burgess A W; Simpson R J
A two-dimensional gel database of human colon carcinoma proteins.
Electrophoresis 1997;18(3-4):605-13.
1997: Rasmussen R K; Ji H; Eddes J S; Moritz R L; Reid G E; Simpson R J; Dorow D S
Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
Electrophoresis 1997;18(3-4):588-98.
1997: Zhang J G; Matthews J M; Ward L D; Simpson R J
Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state.
Biochemistry 1997;36(9):2380-9.
1997: Heath J K; White S J; Johnstone C N; Catimel B; Simpson R J; Moritz R L; Tu G F; Ji H; Whitehead R H; Groenen L C; Scott A M; Ritter G; Cohen L; Welt S; Old L J; Nice E C; Burgess A W
The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):469-74.
1996: Hodder A N; Crewther P E; Matthew M L; Reid G E; Moritz R L; Simpson R J; Anders R F
The disulfide bond structure of Plasmodium apical membrane antigen-1.
The Journal of biological chemistry 1996;271(46):29446-52.
1996: Catimel B; Ritter G; Welt S; Old L J; Cohen L; Nerrie M A; White S J; Heath J K; Demediuk B; Domagala T; Lee F T; Scott A M; Tu G F; Ji H; Moritz R L; Simpson R J; Burgess A W; Nice E C
Purification and characterization of a novel restricted antigen expressed by normal and transformed human colonic epithelium.
The Journal of biological chemistry 1996;271(41):25664-70.
1996: Ward L D; Hammacher A; Howlett G J; Matthews J M; Fabri L; Moritz R L; Nice E C; Weinstock J; Simpson R J
Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
The Journal of biological chemistry 1996;271(33):20138-44.
1996: Moritz R L; Eddes J S; Reid G E; Simpson R J
S-pyridylethylation of intact polyacrylamide gels and in situ digestion of electrophoretically separated proteins: a rapid mass spectrometric method for identifying cysteine-containing peptides.
Electrophoresis 1996;17(5):907-17.
1996: Du H; Simpson R J; Clarke A E; Bacic A
Molecular characterization of a stigma-specific gene encoding an arabinogalactan-protein (AGP) from Nicotiana alata.
The Plant journal : for cell and molecular biology 1996;9(3):313-23.
1996: Lackmann M; Bucci T; Mann R J; Kravets L A; Viney E; Smith F; Moritz R L; Carter W; Simpson R J; Nicola N A; Mackwell K; Nice E C; Wilks A F; Boyd A W
Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2523-7.
1996: Hammacher A; Simpson R J; Nice E C
The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex.
The Journal of biological chemistry 1996;271(10):5464-73.
1995: Dorow D S; Devereux L; Tu G F; Price G; Nicholl J K; Sutherland G R; Simpson R J
Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.
European journal of biochemistry / FEBS 1995;234(2):492-500.
1995: Ward L D; Matthews J M; Zhang J G; Simpson R J
Equilibrium denaturation of recombinant murine interleukin-6: effect of pH, denaturants, and salt on formation of folding intermediates.
Biochemistry 1995;34(37):11652-9.
1995: Mau S L; Chen C G; Pu Z Y; Moritz R L; Simpson R J; Bacic A; Clarke A E
Molecular cloning of cDNAs encoding the protein backbones of arabinogalactan-proteins from the filtrate of suspension-cultured cells of Pyrus communis and Nicotiana alata.
The Plant journal : for cell and molecular biology 1995;8(2):269-81.
1995: Liu Z; Simpson R J; Cheers C
Interaction of interleukin-6, tumour necrosis factor and interleukin-1 during Listeria infection.
Immunology 1995;85(4):562-7.
1995: Liu Z; Simpson R J; Cheers C
Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes.
Infection and immunity 1995;63(7):2790-2.
1995: Ward L D; Howlett G J; Hammacher A; Moritz R L; Simpson R J
Stoichiometry of the interleukin-6 high affinity receptor complex.
Annals of the New York Academy of Sciences 1995;762():471-3.
1995: Hammacher A; Ward L D; Weinstock J; Simpson R J
Structural and biological characterization of murine-human interleukin-6 chimeras.
Annals of the New York Academy of Sciences 1995;762():422-3.
1995: Reid G E; Ji H; Eddes J S; Moritz R L; Simpson R J
Nonreducing two-dimensional polyacrylamide gel electrophoretic analysis of human colonic proteins.
Electrophoresis 1995;16(7):1120-30.
1995: Morton C J; Bai H; Zhang J G; Hammacher A; Norton R S; Simpson R J; Mabbutt B C
NMR studies of the solution properties of recombinant murine interleukin-6.
Biochimica et biophysica acta 1995;1249(2):189-203.
1995: Heath R L; Barton P A; Simpson R J; Reid G E; Lim G; Anderson M A
Characterization of the protease processing sites in a multidomain proteinase inhibitor precursor from Nicotiana alata.
European journal of biochemistry / FEBS 1995;230(1):250-7.
1995: Tu G F; Reid G E; Zhang J G; Moritz R L; Simpson R J
C-terminal extension of truncated recombinant proteins in Escherichia coli with a 10Sa RNA decapeptide.
The Journal of biological chemistry 1995;270(16):9322-6.
1995: Ward L D; Howlett G J; Hammacher A; Weinstock J; Yasukawa K; Simpson R J; Winzor D J
Use of a biosensor with surface plasmon resonance detection for the determination of binding constants: measurement of interleukin-6 binding to the soluble interleukin-6 receptor.
Biochemistry 1995;34(9):2901-7.
1994: Hammacher A; Ward L D; Weinstock J; Treutlein H; Yasukawa K; Simpson R J
Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding.
Protein science : a publication of the Protein Society 1994;3(12):2280-93.
1994: Du H; Simpson R J; Moritz R L; Clarke A E; Bacic A
Isolation of the protein backbone of an arabinogalactan-protein from the styles of Nicotiana alata and characterization of a corresponding cDNA.
The Plant cell 1994;6(11):1643-53.
1994: Chen C G; Pu Z Y; Moritz R L; Simpson R J; Bacic A; Clarke A E; Mau S L
Molecular cloning of a gene encoding an arabinogalactan-protein from pear (Pyrus communis) cell suspension culture.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10305-9.
1994: Ward L D; Howlett G J; Discolo G; Yasukawa K; Hammacher A; Moritz R L; Simpson R J
High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.
The Journal of biological chemistry 1994;269(37):23286-9.
1994: Liu Z; Simpson R J; Cheers C
Role of IL-6 in activation of T cells for acquired cellular resistance to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5375-80.
1994: Smith P M; Avjioglu A; Ward L R; Simpson R J; Knox R B; Singh M B
Isolation and characterization of group-I isoallergens from Bermuda grass pollen.
International archives of allergy and immunology 1994;104(1):57-64.
1994: Morton C J; Simpson R J; Norton R S
Solution structure of synthetic peptides corresponding to the C-terminal helix of interleukin-6.
European journal of biochemistry / FEBS 1994;219(1-2):97-107.
1993: Zhang J G; Reid G E; Moritz R L; Ward L D; Simpson R J
Specific covalent modification of the tryptophan residues in murine interleukin-6. Effect on biological activity and conformational stability.
European journal of biochemistry / FEBS 1993;217(1):53-9.
1993: Ward L D; Hammacher A; Zhang J G; Weinstock J; Yasukawa K; Morton C J; Norton R S; Simpson R J
Role of the C-terminus in the activity, conformation, and stability of interleukin-6.
Protein science : a publication of the Protein Society 1993;2(9):1472-81.
1993: Fabri L; Maruta H; Muramatsu H; Muramatsu T; Simpson R J; Burgess A W; Nice E C
Structural characterisation of native and recombinant forms of the neurotrophic cytokine MK.
Journal of chromatography 1993;646(1):213-25.
1993: Ward L D; Zhang J G; Checkley G; Preston B; Simpson R J
Effect of pH and denaturants on the folding and stability of murine interleukin-6.
Protein science : a publication of the Protein Society 1993;2(8):1291-300.
1993: Ji H; Baldwin G S; Burgess A W; Moritz R L; Ward L D; Simpson R J
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
The Journal of biological chemistry 1993;268(18):13396-405.
1993: Lackmann M; Rajasekariah P; Iismaa S E; Jones G; Cornish C J; Hu S; Simpson R J; Moritz R L; Geczy C L
Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2981-91.
1993: Atkinson A H; Heath R L; Simpson R J; Clarke A E; Anderson M A
Proteinase inhibitors in Nicotiana alata stigmas are derived from a precursor protein which is processed into five homologous inhibitors.
The Plant cell 1993;5(2):203-13.
1993: Nicola N A; Cross B; Simpson R J
The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications.
Biochemical and biophysical research communications 1993;190(1):20-6.
1992: Simpson R J; Tsugita A; Celis J E; Garrels J I; Mewes H W
Workshop on two-dimensional gel protein databases.
Electrophoresis 1992;13(12):1055-61.
1992: Fabri L; Nice E C; Ward L D; Maruta H; Burgess A W; Simpson R J
Characterization of bovine heparin-binding neurotrophic factor (HBNF): assignment of disulfide bonds.
Biochemistry international 1992;28(1):1-9.
1992: Liu Z; Simpson R J; Cheers C
Recombinant interleukin-6 protects mice against experimental bacterial infection.
Infection and immunity 1992;60(10):4402-6.
1992: Layton M J; Cross B A; Metcalf D; Ward L D; Simpson R J; Nicola N A
A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8616-20.
1992: Zhang J G; Moritz R L; Reid G E; Ward L D; Simpson R J
Purification and characterization of a recombinant murine interleukin-6. Isolation of N- and C-terminally truncated forms.
European journal of biochemistry / FEBS 1992;207(3):903-13.
1992: Moritz R L; Simpson R J
Application of capillary reversed-phase high-performance liquid chromatography to high-sensitivity protein sequence analysis.
Journal of chromatography 1992;599(1-2):119-30.
1992: Lackmann M; Cornish C J; Simpson R J; Moritz R L; Geczy C L
Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins.
The Journal of biological chemistry 1992;267(11):7499-504.
1992: Ward L D; Shi P T; Simpson R J
Binding of anti-human-interleukin-6 monoclonal antibodies to synthetic peptides of human interleukin-6 studied using surface plasmon resonance.
Biochemistry international 1992;26(3):559-65.
1992: Reid G E; Simpson R J
Automated solid-phase peptide synthesis: use of 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate for coupling of tert-butyloxycarbonyl amino acids.
Analytical biochemistry 1992;200(2):301-9.
1992: Nice E C; Fabri L; Hammacher A; Holden J; Simpson R J; Burgess A W
The purification of a Rap1 GTPase-activating protein from bovine brain cytosol.
The Journal of biological chemistry 1992;267(3):1546-53.
1991: Layton J E; Morstyn G; Fabri L J; Reid G E; Burgess A W; Simpson R J; Nice E C
Identification of a functional domain of human granulocyte colony-stimulating factor using neutralizing monoclonal antibodies.
The Journal of biological chemistry 1991;266(35):23815-23.
1991: Nice E C; Fabri L; Whitehead R H; James R; Simpson R J; Burgess A W
The major colonic cell mitogen extractable from colonic mucosa is an N terminally extended form of basic fibroblast growth factor.
The Journal of biological chemistry 1991;266(22):14425-30.
1991: Griffith I J; Smith P M; Pollock J; Theerakulpisut P; Avjioglu A; Davies S; Hough T; Singh M B; Simpson R J; Ward L D
Cloning and sequencing of Lol pI, the major allergenic protein of rye-grass pollen.
FEBS letters 1991;279(2):210-5.
1991: Singh M B; Hough T; Theerakulpisut P; Avjioglu A; Davies S; Smith P M; Taylor P; Simpson R J; Ward L D; McCluskey J
Isolation of cDNA encoding a newly identified major allergenic protein of rye-grass pollen: intracellular targeting to the amyloplast.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1384-8.
1991: Baldwin G S; Moritz R L; Rubira M; Seet K L; Weinstock J; Simpson R J
Purification and partial amino acid sequence of annexin V from porcine gastric mucosal membranes.
Comparative biochemistry and physiology. B, Comparative biochemistry 1991;100(4):661-5.
1990: Ward L D; Hong J; Whitehead R H; Simpson R J
Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.
Electrophoresis 1990;11(10):883-91.
1990: Ward L D; Reid G E; Moritz R L; Simpson R J
Strategies for internal amino acid sequence analysis of proteins separated by polyacrylamide gel electrophoresis.
Journal of chromatography 1990;519(1):199-216.
1990: Simpson R J; Reid G E; Moritz R L; Morton C; Norton R S
Complete amino acid sequence of tenebrosin-C, a cardiac stimulatory and haemolytic protein from the sea anemone Actinia tenebrosa.
European journal of biochemistry / FEBS 1990;190(2):319-28.
1990: Jahnen W; Ward L D; Reid G E; Moritz R L; Simpson R J
Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels.
Biochemical and biophysical research communications 1990;166(1):139-45.
1990: Baldwin G S; Bacic T; Chandler R; Grego B; Pedersen J; Simpson R J; Toh B H; Weinstock J
Isolation of transferrin from porcine gastric mucosa: comparison with porcine serum transferrin.
Comparative biochemistry and physiology. B, Comparative biochemistry 1990;95(2):261-8.
1989: Simpson R J; Ward L D; Reid G E; Batterham M P; Moritz R L
Peptide mapping and internal sequencing of proteins electroblotted from two-dimensional gels onto polyvinylidene difluoride membranes. A chromatographic procedure for separating proteins from detergents.
Journal of chromatography 1989;476():345-61.
1989: Simpson R J; Moritz R L; Rubira M R; Gorman J J; Van Snick J
Complete amino acid sequence of a new murine T-cell growth factor P40.
European journal of biochemistry / FEBS 1989;183(3):715-22.
1989: Simpson R J; Moritz R L
Chromatographic fractionation of proteins at high organic solvent modifier concentrations.
Journal of chromatography 1989;474(2):418-23.
1989: Jahnen W; Batterham M P; Clarke A E; Moritz R L; Simpson R J
Identification, isolation, and N-terminal sequencing of style glycoproteins associated with self-incompatibility in Nicotiana alata.
The Plant cell 1989;1(5):493-9.
1989: Simpson R J; Moritz R L; Begg G S; Rubira M R; Nice E C
Micropreparative procedures for high sensitivity sequencing of peptides and proteins.
Analytical biochemistry 1989;177(2):221-36.
1989: Van Snick J; Goethals A; Renauld J C; Van Roost E; Uyttenhove C; Rubira M R; Moritz R L; Simpson R J
Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).
The Journal of experimental medicine 1989;169(1):363-8.
1989: Simpson R J; Nice E C; Moritz R L; Stewart G A
Structural studies on the allergen Der p1 from the house dust mite Dermatophagoides pteronyssinus: similarity with cysteine proteinases.
Protein sequences & data analysis 1989;2(1):17-21.
1989: Van Snick J; Renauld J C; Simpson R J; Uyttenhove C; Vink A
Mouse IL-6. A hybridoma growth factor with multiple effects on normal B and T cells.
Annals of the New York Academy of Sciences 1989;557():206-13, discussion 213-4.
1988: Simpson R J; Moritz R L; Van Roost; Van Snick J
Characterization of a recombinant murine interleukin-6: assignment of disulfide bonds.
Biochemical and biophysical research communications 1988;157(1):364-72.
1988: Simpson R J; Moritz R L; Rubira M R; Van Snick J
Murine hybridoma/plasmacytoma growth factor. Complete amino-acid sequence and relation to human interleukin-6.
European journal of biochemistry / FEBS 1988;176(1):187-97.
1988: Uyttenhove C; Simpson R J; Van Snick J
Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6934-8.
1988: Simpson R J; Hilton D J; Nice E C; Rubira M R; Metcalf D; Gearing D P; Gough N M; Nicola N A
Structural characterization of a murine myeloid leukaemia inhibitory factor.
European journal of biochemistry / FEBS 1988;175(3):541-7.
1988: Burgess A W; Lloyd C J; Smith S; Stanley E; Walker F; Fabri L; Simpson R J; Nice E C
Murine epidermal growth factor: structure and function.
Biochemistry 1988;27(14):4977-85.
1988: Van Snick J; Cayphas S; Szikora J P; Renauld J C; Van Roost E; Boon T; Simpson R J
cDNA cloning of murine interleukin-HP1: homology with human interleukin 6.
European journal of immunology 1988;18(2):193-7.
1987: Gearing D P; Gough N M; King J A; Hilton D J; Nicola N A; Simpson R J; Nice E C; Kelso A; Metcalf D
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
The EMBO journal 1987;6(13):3995-4002.
1987: Simpson R J; Moritz R L; Lloyd C J; Fabri L J; Nice E C; Rubira M R; Burgess A W
Primary structure of ovine pituitary basic fibroblast growth factor.
FEBS letters 1987;224(1):128-32.
1987: Van Damme J; Cayphas S; Van Snick J; Conings R; Put W; Lenaerts J P; Simpson R J; Billiau A
Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cell-derived B-cell stimulatory factor-2 (interleukin-6).
European journal of biochemistry / FEBS 1987;168(3):543-50.
1987: Cayphas S; Van Damme J; Vink A; Simpson R J; Billiau A; Van Snick J
Identification of an interleukin HP1-like plasmacytoma growth factor produced by L cells in response to viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):2965-9.
1987: Simpson R J; Nice E C; Nicola N A
Structural studies on the murine granulocyte colony-stimulating factor.
Biological chemistry Hoppe-Seyler 1987;368(10):1327-31.
1987: Simpson R J; Grego B; Govindan M V; Gronemeyer H
Peptide sequencing of the chick oviduct progesterone receptor form B.
Molecular and cellular endocrinology 1987;52(3):177-84.
1987: Simpson R J; Moritz R L; Nice E E; Grego B
A high-performance liquid chromatography procedure for recovering subnanomole amounts of protein from SDS-gel electroeluates for gas-phase sequence analysis.
European journal of biochemistry / FEBS 1987;165(1):21-9.
1987: Van Damme J; Opdenakker G; Simpson R J; Rubira M R; Cayphas S; Vink A; Billiau A; Van Snick J
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.
The Journal of experimental medicine 1987;165(3):914-9.
1987: Ratajczak T; Comber M; Moir R; Hähnel R; Grego B; Rubira M R; Simpson R J
The amino-terminal sequence of the 85-90K nonhormone binding component of the molybdate-stabilized estradiol receptor from calf uterus.
Biochemical and biophysical research communications 1987;143(1):218-24.
1987: Baldwin G S; Chandler R; Seet K L; Weinstock J; Grego B; Rubira M; Mortiz R L; Simpson R J
Structural studies on a 75-kDa glycoprotein isolated from porcine gastric mucosal membranes: close homology with the 78-kDa glucose-regulated family of proteins.
Protein sequences & data analysis 1987;1(1):7-12.
1986: Van Snick J; Cayphas S; Vink A; Uyttenhove C; Coulie P G; Rubira M R; Simpson R J
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9679-83.
1986: Simpson R J; Moritz R L; Nice E C; Grego B; Yoshizaki F; Sugimura Y; Freeman H C; Murata M
Complete amino acid sequence of plastocyanin from a green alga, Enteromorpha prolifera.
European journal of biochemistry / FEBS 1986;157(3):497-506.
1986: Grego B; Van Driel I R; Goding J W; Nice E C; Simpson R J
Use of microbore high-performance liquid chromatography for purifying subnanomole levels of polypeptides for microsequencing. Structural studies on the murine plasma cell antigen PC-1.
International journal of peptide and protein research 1986;27(2):201-7.
1985: Simpson R J; Smith J A; Moritz R L; O'Hare M J; Rudland P S; Morrison J R; Lloyd C J; Grego B; Burgess A W; Nice E C
Rat epidermal growth factor: complete amino acid sequence. Homology with the corresponding murine and human proteins; isolation of a form truncated at both ends with full in vitro biological activity.
European journal of biochemistry / FEBS 1985;153(3):629-37.
1985: Grego B; Van Driel I R; Stearne P A; Goding J W; Nice E C; Simpson R J
A microbore high-performance liquid chromatography strategy for the purification of polypeptides for gas-phase sequence analysis. Structural studies on the murine transferrin receptor.
European journal of biochemistry / FEBS 1985;148(3):485-91.
1985: Stearne P A; van Driel I R; Grego B; Simpson R J; Goding J W
The murine plasma cell antigen PC-1: purification and partial amino acid sequence.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(1):443-8.
1984: van Driel I R; Stearne P A; Grego B; Simpson R J; Goding J W
The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(6):3220-4.
1984: Grego B; Baldwin G S; Knessel J A; Simpson R J; Morgan F J; Hearn M T
High-performance liquid chromatography of amino acids, peptides and proteins. LVIII. Application of reversed-phase high-performance liquid chromatography to the separation of tyrosine-specific phosphorylated polypeptides related to human growth hormone.
Journal of chromatography 1984;297():21-9.
1983: Baldwin G S; Grego B; Hearn M T; Knesel J A; Morgan F J; Simpson R J
Phosphorylation of human growth hormone by the epidermal growth factor-stimulated tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(17):5276-80.

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