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Stephen Sims

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Stephen M Sims; Danielle M Lapierre; Nattapon Panupinthu; Alexey Pereverzev; S Jeffrey Dixon
Lysophosphatidic acid: A potential mediator of osteoblast-osteoclast signaling in bone.
Ting Zhang; Peter Chidiac; Jenny Li; Xiangru Lu; Stephen M Sims; Qingping Feng
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia.
Juan P Reyes; Stephen M Sims; S Jeffrey Dixon
P2 receptor expression, signaling and function in osteoclasts.

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2013: Stephen M Sims; Danielle M Lapierre; Nattapon Panupinthu; Alexey Pereverzev; S Jeffrey Dixon
Lysophosphatidic acid: A potential mediator of osteoblast-osteoclast signaling in bone.
Biochimica et biophysica acta 2013;1831(1):109-16.
2012: Ting Zhang; Peter Chidiac; Jenny Li; Xiangru Lu; Stephen M Sims; Qingping Feng
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia.
Basic research in cardiology 2012;107(2):254.
2011: Juan P Reyes; Stephen M Sims; S Jeffrey Dixon
P2 receptor expression, signaling and function in osteoclasts.
Frontiers in bioscience (Scholar edition) 2011;3():1101-18.
2010: Danielle M Lapierre; Natsuko Tanabe; Alexey Pereverzev; Martha Spencer; Ryan P P Shugg; S Jeffrey Dixon; Stephen M Sims
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.
The Journal of biological chemistry 2010;285(33):25792-801.
2010: Paola Algara-Suárez; Rebeca Mejía-Elizondo; Stephen M Sims; Victor M Saavedra-Alanis; Ricardo Espinosa-Tanguma
The 1.3 isoform of Na+-Ca 2+ exchanger expressed in guinea pig tracheal smooth muscle is less sensitive to KB-R7943.
Journal of physiology and biochemistry 2010;66(2):117-25.
2009: Dylan E Burger; Xiangru Lu; Ming Lei; Fu-Li Xiang; Lamis Hammoud; Mao Jiang; Hao Wang; Douglas L Jones; Stephen M Sims; Qingping Feng
Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice.
Circulation 2009;120(14):1345-54.
2009: Matthew W Grol; Nattapon Panupinthu; Jasminka Korcok; Stephen M Sims; S Jeffrey Dixon
Expression, signaling, and function of P2X7 receptors in bone.
Purinergic signalling 2009;5(2):205-21.
2008: Stephen M Sims; Tom Chrones; Harold G Preiksaitis
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
The Journal of pharmacology and experimental therapeutics 2008;327(1):178-86.
2008: Nattapon Panupinthu; Joseph T Rogers; Lin Zhao; Luis Pastor Solano-Flores; Fred Possmayer; Stephen M Sims; S Jeffrey Dixon
P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis.
The Journal of cell biology 2008;181(5):859-71.
2008: Jason R Kovac; Tom Chrones; Stephen M Sims
Temporal and spatial dynamics underlying capacitative calcium entry in human colonic smooth muscle.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G88-98.
2008: Alexey Pereverzev; Svetlana V Komarova; Jasminka Korcok; Souzan Armstrong; Gilles B Tremblay; S Jeffrey Dixon; Stephen M Sims
Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway.
Bone 2008;42(1):150-61.
2007: Beatrice A Williams; Stephen M Sims
Calcium sparks activate calcium-dependent Cl- current in rat corpus cavernosum smooth muscle cells.
American journal of physiology. Cell physiology 2007;293(4):C1239-51.
2007: Azza Gramoun; Seema Shorey; Jill D Bashutski; S Jeffrey Dixon; Stephen M Sims; Johan N M Heersche; Morris F Manolson
Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro.
Journal of cellular biochemistry 2007;102(2):341-52.
2007: Nicola Geoghegan-Morphet; Dylan Burger; Xiangru Lu; Venkatachalem Sathish; Tianqing Peng; Stephen M Sims; Qingping Feng
Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes.
Cardiovascular research 2007;75(2):408-16.
2007: Paola Algara-Suárez; Catalina Romero-Méndez; Tom Chrones; Sergio Sánchez-Armass; Ulises Meza; Stephen M Sims; Ricardo Espinosa-Tanguma
Functional coupling between the Na+/Ca2+ exchanger and nonselective cation channels during histamine stimulation in guinea pig tracheal smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2007;293(1):L191-8.
2007: Souzan Armstrong; Jasminka Korcok; Stephen M Sims; S Jeffrey Dixon
Activation of transcription factors by extracellular nucleotides in immune and related cell types.
Purinergic signalling 2007;3(1-2):59-69.
2007: Nattapon Panupinthu; Lin Zhao; Fred Possmayer; Hua Zhu Ke; Stephen M Sims; S Jeffrey Dixon
P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid.
The Journal of biological chemistry 2007;282(5):3403-12.
2006: Jason R Kovac; Tom Chrones; Harold G Preiksaitis; Stephen M Sims
Tachykinin receptor expression and function in human esophageal smooth muscle.
The Journal of pharmacology and experimental therapeutics 2006;318(2):513-20.
2006: Venkatachalem Sathish; Ande Xu; Morris Karmazyn; Stephen M Sims; Njanoor Narayanan
Mechanistic basis of differences in Ca2+ -handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H88-96.
2006: D Holstead Jones; Tomoki Nakashima; Otto H Sanchez; Ivona Kozieradzki; Svetlana V Komarova; Ildiko Sarosi; Sean Morony; Evelyn Rubin; Renu Sarao; Carlo V Hojilla; Vukoslav Komnenovic; Young-Yun Kong; Martin Schreiber; S Jeffrey Dixon; Stephen M Sims; Rama Khokha; Teiji Wada; Josef M Penninger
Regulation of cancer cell migration and bone metastasis by RANKL.
Nature 2006;440(7084):692-6.
2005: Asma Yaghi; Stephen M Sims
Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L1061-74.
2005: Jason R Kovac; Harold G Preiksaitis; Stephen M Sims
Functional and molecular analysis of L-type calcium channels in human esophagus and lower esophageal sphincter smooth muscle.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(6):G998-1006.
2005: Jasminka Korcok; Lin N Raimundo; Xiaobing Du; Stephen M Sims; S Jeffrey Dixon
P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts.
The Journal of biological chemistry 2005;280(17):16909-15.
2005: Beatrice A Williams; Caiqiong Liu; Ling Deyoung; Gerald B Brock; Stephen M Sims
Regulation of intracellular Ca2+ release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP.
American journal of physiology. Cell physiology 2005;288(3):C650-8.
2005: Svetlana V Komarova; Alexey Pereverzev; Jonathan W Shum; Stephen M Sims; S Jeffrey Dixon
Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2643-8.
2004: Jasminka Korcok; Lin N Raimundo; Hua Zhu Ke; Stephen M Sims; S Jeffrey Dixon
Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(4):642-51.
2003: Svetlana V Komarova; Jeffrey Shum; L A Paige; Stephen M Sims; S Jeffrey Dixon
Regulation of osteoclasts by calcitonin and amphiphilic calcitonin conjugates: role of cytosolic calcium.
Calcified tissue international 2003;73(3):265-73.
2003: Svetlana V Komarova; Robert J Smith; S Jeffrey Dixon; Stephen M Sims; Lindi M Wahl
Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling.
Bone 2003;33(2):206-15.
2003: Hua Zhu Ke; Hong Qi; A Frederik Weidema; Qing Zhang; Nattapon Panupinthu; D Todd Crawford; William A Grasser; Vishwas M Paralkar; Mei Li; Laurent P Audoly; Christopher A Gabel; Webster S S Jee; S Jeffrey Dixon; Stephen M Sims; David D Thompson
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1356-67.
2003: Jian Wang; Lisanne G Laurier; Stephen M Sims; Harold G Preiksaitis
Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(6):G1074-83.
2003: Tom Karkanis; Shaohua Li; J Geoffrey Pickering; Stephen M Sims
Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.
American journal of physiology. Heart and circulatory physiology 2003;284(6):H2325-34.
2003: Svetlana V Komarova; Mary F Pilkington; A Frederik Weidema; S Jeffrey Dixon; Stephen M Sims
RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts.
The Journal of biological chemistry 2003;278(10):8286-93.
2003: Tom Karkanis; Ling DeYoung; Gerald B Brock; Stephen M Sims
Ca2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(1):301-13.
2002: Maneesh A Deshpande; Jian Wang; Harold G Preiksaitis; Lisanne G Laurier; Stephen M Sims
Characterization of a voltage-dependent Na(+) current in human esophageal smooth muscle.
American journal of physiology. Cell physiology 2002;283(4):C1045-55.
2001: L N Naemsch; S Jeffrey Dixon; Stephen M Sims
Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts.
The Journal of biological chemistry 2001;276(42):39107-14.
2001: Shaohua Li; Yao-Shan Fan; LH Chow; Caroline Van Den Diepstraten; Eric van der Veer; Stephen M Sims; J Geoffrey Pickering
Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery.
Circulation research 2001;89(6):517-25.
2001: Mary F Pilkington; Stephen M Sims; S Jeffrey Dixon
Transforming growth factor-beta induces osteoclast ruffling and chemotaxis: potential role in osteoclast recruitment.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(7):1237-47.
2001: A Frederik Weidema; S Jeffrey Dixon; Stephen M Sims
Activation of P2Y but not P2X(4) nucleotide receptors causes elevation of [Ca2+]i in mammalian osteoclasts.
American journal of physiology. Cell physiology 2001;280(6):C1531-9.
2001: Svetlana V Komarova; S Jeffrey Dixon; Stephen M Sims
Osteoclast ion channels: potential targets for antiresorptive drugs.
Current pharmaceutical design 2001;7(8):637-54.
2001: Tom Karkanis; Y Jiao; B R Hurley; Shaohua Li; J Geoffrey Pickering; Stephen M Sims
Functional receptor-channel coupling compared in contractile and proliferative human vascular smooth muscle.
Journal of cellular physiology 2001;187(2):244-55.
2000: Jian Wang; PS Krysiak; Lisanne G Laurier; Stephen M Sims; Harold G Preiksaitis
Human esophageal smooth muscle cells express muscarinic receptor subtypes M(1) through M(5).
American journal of physiology. Gastrointestinal and liver physiology 2000;279(5):G1059-69.
2000: A Frederik Weidema; S Jeffrey Dixon; Stephen M Sims
Electrophysiological characterization of ion channels in osteoclasts isolated from human deciduous teeth.
Bone 2000;27(1):5-11.
1999: L N Naemsch; A Frederik Weidema; Stephen M Sims; Tully Underhill; S Jeffrey Dixon
P2X(4) purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts.
Journal of cell science 1999;112 ( Pt 23)():4425-35.
1999: Ichiro Nakamura; Mary F Pilkington; Päivi Lakkakorpi; Lorraine Lipfert; Stephen M Sims; S Jeffrey Dixon; Gideon A Rodan; LT Duong
Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone.
Journal of cell science 1999;112 ( Pt 22)():3985-93.
1999: G R Wade; Lisanne G Laurier; Harold G Preiksaitis; Stephen M Sims
Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction.
The American journal of physiology 1999;277(4 Pt 1):G885-95.
1999: B R Hurley; Harold G Preiksaitis; Stephen M Sims
Characterization and regulation of Ca2+-dependent K+ channels in human esophageal smooth muscle.
The American journal of physiology 1999;276(4 Pt 1):G843-52.
1999: S H Wiebe; Stephen M Sims; S Jeffrey Dixon
Calcium signalling via multiple P2 purinoceptor subtypes in rat osteoclasts.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(6):323-37.
1998: GP Thomas; Stephen M Sims; Michael A Cook; Morris Karmazyn
Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activation.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1208-14.
1998: B Wang; Stephen M Sims
CCK regulates nonselective cation channels in guinea pig gastric smooth muscle cells.
The American journal of physiology 1998;274(4 Pt 1):G709-17.
1998: Mary F Pilkington; Stephen M Sims; S Jeffrey Dixon
Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(4):688-94.
1997: Stephen M Sims; Y Jiao; Harold G Preiksaitis
Regulation of intracellular calcium in human esophageal smooth muscles.
The American journal of physiology 1997;273(5 Pt 1):C1679-89.
1997: A Frederik Weidema; J Barbera; S Jeffrey Dixon; Stephen M Sims
Extracellular nucleotides activate non-selective cation and Ca(2+)-dependent K+ channels in rat osteoclasts.
The Journal of physiology 1997;503 ( Pt 2)():303-15.
1997: GP Thomas; Stephen M Sims; Morris Karmazyn
Differential effects of endothelin-1 on basal and isoprenaline-enhanced Ca2+ current in guinea-pig ventricular myocytes.
The Journal of physiology 1997;503 ( Pt 1)():55-65.
1996: Stephen M Sims; Y Jiao; Z G Zheng
Intracellular calcium stores in isolated tracheal smooth muscle cells.
The American journal of physiology 1996;271(2 Pt 1):L300-9.
1996: Samuel Wiebe; M Hafezi; H S Sandhu; Stephen M Sims; S Jeffrey Dixon
Osteoclast activation in inflammatory periodontal diseases.
Oral diseases 1996;2(2):167-80.
1996: G R Wade; J Barbera; Stephen M Sims
Cholinergic inhibition of Ca2+ current in guinea-pig gastric and tracheal smooth muscle cells.
The Journal of physiology 1996;491 ( Pt 2)():307-19.
1995: L J Janssen; Stephen M Sims
Ca(2+)-dependent Cl- current in canine tracheal smooth muscle cells.
The American journal of physiology 1995;269(1 Pt 1):C163-9.
1994: M R Gravel; Z G Zheng; Stephen M Sims; S Jeffrey Dixon
Platelet-activating factor induces pseudopod formation in calcitonin-treated rabbit osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(11):1769-76.
1994: L J Janssen; Stephen M Sims
Spontaneous transient inward currents and rhythmicity in canine and guinea-pig tracheal smooth muscle cells.
Pflügers Archiv : European journal of physiology 1994;427(5-6):473-80.
1994: S A Arkett; S Jeffrey Dixon; Stephen M Sims
Effects of extracellular calcium and protons on osteoclast potassium currents.
The Journal of membrane biology 1994;140(2):163-71.
1994: L J Janssen; Stephen M Sims
Substance P activates Cl- and K+ conductances in guinea-pig tracheal smooth muscle cells.
Canadian journal of physiology and pharmacology 1994;72(6):705-10.
1994: H S Tong; D D Sakai; Stephen M Sims; S Jeffrey Dixon; M Yamin; Steven R Goldring; Malcolm Snead; Cedric Minkin
Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(4):577-84.
1994: M E Kelly; S Jeffrey Dixon; Stephen M Sims
Outwardly rectifying chloride current in rabbit osteoclasts is activated by hyposmotic stimulation.
The Journal of physiology 1994;475(3):377-89.
1994: S A Arkett; S Jeffrey Dixon; Stephen M Sims
Lamellipod extension and K+ current in osteoclasts are regulated by different types of G proteins.
Journal of cell science 1994;107 ( Pt 2)():517-26.
1994: S A Arkett; J Dixon; J N Yang; D D Sakai; Cedric Minkin; Stephen M Sims
Mammalian osteoclasts express a transient potassium channel with properties of Kv1.3.
Receptors & channels 1994;2(4):281-93.
1993: L J Janssen; Stephen M Sims
Emptying and refilling of Ca2+ store in tracheal myocytes as indicated by ACh-evoked currents and contraction.
The American journal of physiology 1993;265(4 Pt 1):C877-86.
1993: G R Wade; Stephen M Sims
Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca(2+)-dependent K+ channel.
The American journal of physiology 1993;265(3 Pt 1):C658-65.
1993: L J Janssen; Stephen M Sims
Histamine activates Cl- and K+ currents in guinea-pig tracheal myocytes: convergence with muscarinic signalling pathway.
The Journal of physiology 1993;465():661-77.
1993: Z G Zheng; D A Wood; Stephen M Sims; S Jeffrey Dixon
Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro.
The American journal of physiology 1993;264(1 Pt 1):E74-81.
1992: S A Arkett; S Jeffrey Dixon; Stephen M Sims
Substrate influences rat osteoclast morphology and expression of potassium conductances.
The Journal of physiology 1992;458():633-53.
1992: S A Arkett; M E Kelly; S Jeffrey Dixon; Stephen M Sims
Ionic conductances in mammalian osteoclasts.
Annals of the New York Academy of Sciences 1992;671():464-7.
1992: Stephen M Sims
Calcium and potassium currents in canine gastric smooth muscle cells.
The American journal of physiology 1992;262(5 Pt 1):G859-67.
1992: Stephen M Sims
Cholinergic activation of a non-selective cation current in canine gastric smooth muscle is associated with contraction.
The Journal of physiology 1992;449():377-98.
1992: M E Kelly; S Jeffrey Dixon; Stephen M Sims
Inwardly rectifying potassium current in rabbit osteoclasts: a whole-cell and single-channel study.
The Journal of membrane biology 1992;126(2):171-81.
1992: L J Janssen; Stephen M Sims
Acetylcholine activates non-selective cation and chloride conductances in canine and guinea-pig tracheal myocytes.
The Journal of physiology 1992;453():197-218.
1991: Stephen M Sims; M E Kelly; S Jeffrey Dixon
K+ and Cl- currents in freshly isolated rat osteoclasts.
Pflügers Archiv : European journal of physiology 1991;419(3-4):358-70.
1991: Stephen M Sims; B T Lussier; J Kraicer
Somatostatin activates an inwardly rectifying K+ conductance in freshly dispersed rat somatotrophs.
The Journal of physiology 1991;441():615-37.
1991: D A Wood; L K Hapak; Stephen M Sims; S Jeffrey Dixon
Direct effects of platelet-activating factor on isolated rat osteoclasts. Rapid elevation of intracellular free calcium and transient retraction of pseudopods.
The Journal of biological chemistry 1991;266(23):15369-76.
1989: Stephen M Sims; S Jeffrey Dixon
Inwardly rectifying K+ current in osteoclasts.
The American journal of physiology 1989;256(6 Pt 1):C1277-82.