FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Sinclair

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Phenomena

Acetylation

Physiology

Genes & Molecular Sequences

Genes, Fungal

Anatomy

Cell Line

Co-author Network

Publications

TOP 3
Sean M Armour; Eric J Bennett; Craig R Braun; Steven P Gygi; J Wade Harper; Steven B McMahon; Xiao-Yong Zhang; David A Sinclair
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Basil P Hubbard; Yong Jiang; Dudley W Lamming; Jessica E Lee; Jun Li; Alvin J Y Ling; Shaday Michan; Joel Moss; Pui Yee Ng; Bradley L Pentelute; Robert B Perni; Thomas V Riera; Anabela P Rolo; Eli R Schuman; Sean M Armour; Charles A Blum; April W Case; Thomas Considine; Han Dai; Jeremy S Disch; Sook Yen E; James L Ellis; Ana P Gomes; Yoshitomo Hamuro; Konrad T Howitz; Linda A Stevens; Sharon M Sweitzer; George P Vlasuk; Huizhen Zhao; David A Sinclair
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Nathan L Price; Giorgio Ramadori; Anabela P Rolo; Joao S Teodoro; Behzad Varamini; Ana T Varela; Lan Ye; Beamon Agarwal; Joseph A Baur; Roberto Coppari; James G Davis; Rafael de Cabo; Filipe V Duarte; Ana P Gomes; Angela Hafner; Basil P Hubbard; Alvin J Y Ling; Alejandro Martin-Montalvo; Ruin Moaddel; Brian J North; Carlos M Palmeira; David A Sinclair
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Sinclair (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Sean M Armour; Eric J Bennett; Craig R Braun; Steven P Gygi; J Wade Harper; Steven B McMahon; Xiao-Yong Zhang; David A Sinclair
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology 2013;33(8):1487-502.
2013: Basil P Hubbard; Yong Jiang; Dudley W Lamming; Jessica E Lee; Jun Li; Alvin J Y Ling; Shaday Michan; Joel Moss; Pui Yee Ng; Bradley L Pentelute; Robert B Perni; Thomas V Riera; Anabela P Rolo; Eli R Schuman; Sean M Armour; Charles A Blum; April W Case; Thomas Considine; Han Dai; Jeremy S Disch; Sook Yen E; James L Ellis; Ana P Gomes; Yoshitomo Hamuro; Konrad T Howitz; Linda A Stevens; Sharon M Sweitzer; George P Vlasuk; Huizhen Zhao; David A Sinclair
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Science (New York, N.Y.) 2013;339(6124):1216-9.
2012: Nathan L Price; Giorgio Ramadori; Anabela P Rolo; Joao S Teodoro; Behzad Varamini; Ana T Varela; Lan Ye; Beamon Agarwal; Joseph A Baur; Roberto Coppari; James G Davis; Rafael de Cabo; Filipe V Duarte; Ana P Gomes; Angela Hafner; Basil P Hubbard; Alvin J Y Ling; Alejandro Martin-Montalvo; Ruin Moaddel; Brian J North; Carlos M Palmeira; David A Sinclair
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Cell metabolism 2012;15(5):675-90.
2012: Brian J North; David A Sinclair
The intersection between aging and cardiovascular disease.
Circulation research 2012;110(8):1097-108.
2011: Bogdan Beirowski; Judith P Golden; Jason Gustin; Shaday Michan; Brian J North; Robert E Schmidt; David A Sinclair; Andreu Viader; Hiroyasu Yamamoto; Sean M Armour; Johan Auwerx; Robert H Baloh; Jeffrey Milbrandt
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):E952-61.
2011: Giorgio Ramadori; David A Sinclair; Claudia R Vianna; Jason Anderson; Eric D Berglund; Carol F Elias; Renata Frazao; Teppei Fujikawa; Shaday Michan; Roberto Coppari
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.
Cell metabolism 2011;14(3):301-12.
2011: Jing Hua; Karen Guerin; Jing Chen; Shaday Michan; Andreas Stahl; Nathan M Krah; Molly R Seaward; Roberta J Dennison; Aimee M Juan; Colman J Hatton; Przemyslaw Sapieha; David A Sinclair; Lois E H Smith
Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice.
Investigative ophthalmology & visual science 2011;52(5):2809-16.
2010: Angela V Hafner; Jing Dai; Ana P Gomes; Chun-Yang Xiao; Carlos M Palmeira; Anthony Rosenzweig; David A Sinclair
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Aging 2010;2(12):914-23.
2010: Shaday Michan; Ying Li; Maggie Meng-Hsiu Chou; Edoardo Parrella; Huanying Ge; Jeffrey M Long; Joanne S Allard; Kaitlyn Lewis; M Miller; Wei Xu; Ronald F Mervis; Jing Chen; Karen I Guerin; Lois E H Smith; Michael W McBurney; David A Sinclair; Michel Baudry; Rafael de Cabo; Valter D Longo
SIRT1 is essential for normal cognitive function and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(29):9695-707.
2010: Marcia C Haigis; David A Sinclair
Mammalian sirtuins: biological insights and disease relevance.
Annual review of pathology 2010;5():253-95.
2009: David A Sinclair; Philipp Oberdoerffer
The ageing epigenome: damaged beyond repair?
Ageing research reviews 2009;8(3):189-98.
2009: Sean M Armour; Joseph A Baur; Sherry N Hsieh; Abigail Land-Bracha; Sheila M Thomas; David A Sinclair
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.
Aging 2009;1(6):515-28.
2008: Philipp Oberdoerffer; Shaday Michan; Michael McVay; Raul Mostoslavsky; James Vann; Sang-Kyu Park; Andrea Hartlerode; Judith Stegmuller; Angela Hafner; Patrick Loerch; Sarah M Wright; Kevin D Mills; Azad Bonni; Bruce A Yankner; Ralph Scully; Tomas A Prolla; Frederick W Alt; David A Sinclair
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Cell 2008;135(5):907-18.
2008: Ron Firestein; Gil Blander; Shaday Michan; Philipp Oberdoerffer; Shuji Ogino; Jennifer Campbell; Anupama Bhimavarapu; Sandra Luikenhuis; Rafael de Cabo; Charles Fuchs; William C Hahn; Leonard P Guarente; David A Sinclair
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
PloS one 2008;3(4):e2020.
2007: Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature 2007;450(7170):712-6.
2007: Oliver Medvedik; Dudley W Lamming; Keyman D Kim; David A Sinclair
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
PLoS biology 2007;5(10):e261.
2007: Hongying Yang; Tianle Yang; Joseph A Baur; Evelyn Perez; Takashi Matsui; Juan J Carmona; Dudley W Lamming; Nadja C Souza-Pinto; Vilhelm A Bohr; Anthony Rosenzweig; Rafael de Cabo; Anthony A Sauve; David A Sinclair
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Cell 2007;130(6):1095-107.
2007: Philipp Oberdoerffer; David A Sinclair
The role of nuclear architecture in genomic instability and ageing.
Nature reviews. Molecular cell biology 2007;8(9):692-702.
2007: Dohoon Kim; Minh Dang Nguyen; Matthew M Dobbin; Andre Fischer; Farahnaz Sananbenesi; Joseph T Rodgers; Ivana Delalle; Joseph A Baur; Guangchao Sui; Sean M Armour; Pere Puigserver; David A Sinclair; Li-Huei Tsai
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
The EMBO journal 2007;26(13):3169-79.
2007: Hongying Yang; Joseph A Baur; Allen Chen; Christine Miller; Jeffrey K Adams; Anne Kisielewski; Konrad T Howitz; Robert E Zipkin; David A Sinclair
Design and synthesis of compounds that extend yeast replicative lifespan.
Aging cell 2007;6(1):35-43.
2007: Oliver Medvedik; David A Sinclair
Caloric restriction and life span determination of yeast cells.
Methods in molecular biology (Clifton, N.J.) 2007;371():97-109.
2007: Brian J North; David A Sinclair
Sirtuins: a conserved key unlocking AceCS activity.
Trends in biochemical sciences 2007;32(1):1-4.
2006: Michael Yu; Dudley W Lamming; Julian A Eskin; David A Sinclair; Pamela A Silver
The role of protein arginine methylation in the formation of silent chromatin.
Genes & development 2006;20(23):3249-54.
2006: Joseph A Baur; Kevin J Pearson; Nathan L Price; Hamish A Jamieson; Carles Lerin; Avash Kalra; Vinayakumar V Prabhu; Joanne S Allard; Guillermo Lopez-LLuch; Kaitlyn Lewis; Paul J Pistell; Suresh Poosala; Kevin G Becker; Olivier Boss; Dana Gwinn; Mingyi Wang; Sharan Ramaswamy; Kenneth W Fishbein; RICHARD SPENCER; Edward G Lakatta; DAVID LE COUTEUR; Reuben J. Shaw; Plácido Navas; Pere Puigserver; Donald Ingram; Rafael de Cabo; David A Sinclair
Resveratrol improves health and survival of mice on a high-calorie diet.
Nature 2006;444(7117):337-42.
2006: Hongying Yang; Siva Lavu; David A Sinclair
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
Experimental gerontology 2006;41(8):718-26.
2006: Joseph A Baur; David A Sinclair
Therapeutic potential of resveratrol: the in vivo evidence.
Nature reviews. Drug discovery 2006;5(6):493-506.
2005: Antonello Mai; Silvio Massa; Siva Lavu; Riccardo Pezzi; Silvia Simeoni; Rino Ragno; Francesca Romana Mariotti; Francesco Chiani; Giorgio Camilloni; David A Sinclair
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Journal of medicinal chemistry 2005;48(24):7789-95.
2005: Dudley W Lamming; Magda Latorre-Esteves; Oliver Medvedik; Stacy N Wong; Felicia A Tsang; Chen Wang; Su-Ju Lin; David A Sinclair
HST2 mediates SIR2-independent life-span extension by calorie restriction.
Science (New York, N.Y.) 2005;309(5742):1861-4.
2005: David A Sinclair
Toward a unified theory of caloric restriction and longevity regulation.
Mechanisms of ageing and development 2005;126(9):987-1002.
2004: Dudley W Lamming; Jason G Wood; David A Sinclair
Small molecules that regulate lifespan: evidence for xenohormesis.
Molecular microbiology 2004;53(4):1003-9.
2004: Haim Y Cohen; Christine Miller; Kevin J Bitterman; Nathan Wall; Brian Hekking; Benedikt Kessler; Konrad T Howitz; Myriam Gorospe; Rafael de Cabo; David A Sinclair
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;305(5682):390-2.
2004: Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;303(5666):2011-5.
2004: Haim Y Cohen; Siva Lavu; Kevin J Bitterman; Brian Hekking; Thomas A Imahiyerobo; Christine Miller; Roy Frye; Hidde L Ploegh; Benedikt M Kessler; David A Sinclair
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Molecular cell 2004;13(5):627-38.
2003: Rozalyn M Anderson; Magda Latorre-Esteves; Ana Rute Neves; Siva Lavu; Oliver Medvedik; Christopher Taylor; Konrad T Howitz; Helena Santos; David A Sinclair
Yeast life-span extension by calorie restriction is independent of NAD fluctuation.
Science (New York, N.Y.) 2003;302(5653):2124-6.
2003: David A Sinclair
Cell biology. An age of instability.
Science (New York, N.Y.) 2003;301(5641):1859-60.
2003: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Nature 2003;425(6954):191-6.
2003: Kevin J Bitterman; Oliver Medvedik; David A Sinclair
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.
Microbiology and molecular biology reviews : MMBR 2003;67(3):376-99, table of contents.
2003: Rozalyn M Anderson; Kevin J Bitterman; Jason G Wood; Oliver Medvedik; David A Sinclair
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
Nature 2003;423(6936):181-5.
2002: Kevin J Bitterman; Rozalyn M Anderson; Haim Y Cohen; Magda Latorre-Esteves; David A Sinclair
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
The Journal of biological chemistry 2002;277(47):45099-107.
2002: Rozalyn M Anderson; Kevin J Bitterman; Jason G Wood; Oliver Medvedik; Haim Cohen; Stephen S Lin; Jill K Manchester; Jeffrey I Gordon; David A Sinclair
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.
The Journal of biological chemistry 2002;277(21):18881-90.
2002: David A Sinclair
Paradigms and pitfalls of yeast longevity research.
Mechanisms of ageing and development 2002;123(8):857-67.
2002: Jason G Wood; David A Sinclair
TPE or not TPE? It's no longer a question.
Trends in pharmacological sciences 2002;23(1):1-4.
1999: David A Sinclair
Yeast aging research: recent advances and medical relevance.
Cellular and molecular life sciences : CMLS 1999;56(9-10):807-16.