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Jacqueline Sinclair

Research Profile

Anatomy

Chemicals & Drugs

Physiology

Enzyme Induction

Living Beings

Disorders

Porphyria Cutanea Tarda

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TOP 3
Trisha L Noreault-Conti; Jacqueline F Sinclair; Peter R Sinclair; Stephen C Strom; Heidi W Trask; Steven A Wrighton; Ronald M Evans; Abigail Fellows; Judith M Jacobs; Ralph C Nichols
Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.
Nadia Gorman; Adrian Zaharia; Heidi S Trask; Juliana G Szakacs; Nicholas J Jacobs; Judith M Jacobs; Dominic Balestra; Jacqueline F Sinclair; Peter R Sinclair
Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda.
Kristina K Wolf; Sheryl G Wood; Jenna L Allard; Jane A Hunt; Nadia Gorman; Brooke W Walton-Strong; Juliana G Szakacs; Su X Duan; Qin Hao; Michael H Court; Lisa L Von Moltke; David J Greenblatt; Vsevolod E Kostrubsky; Elizabeth H Jeffery; Steven A Wrighton; Frank J Gonzalez; Peter R Sinclair; Jacqueline F Sinclair
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

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2012: Trisha L Noreault-Conti; Jacqueline F Sinclair; Peter R Sinclair; Stephen C Strom; Heidi W Trask; Steven A Wrighton; Ronald M Evans; Abigail Fellows; Judith M Jacobs; Ralph C Nichols
Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.
International immunopharmacology 2012;12(4):651-6.
2007: Nadia Gorman; Adrian Zaharia; Heidi S Trask; Juliana G Szakacs; Nicholas J Jacobs; Judith M Jacobs; Dominic Balestra; Jacqueline F Sinclair; Peter R Sinclair
Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda.
Hepatology (Baltimore, Md.) 2007;46(6):1927-834.
2007: Kristina K Wolf; Sheryl G Wood; Jenna L Allard; Jane A Hunt; Nadia Gorman; Brooke W Walton-Strong; Juliana G Szakacs; Su X Duan; Qin Hao; Michael H Court; Lisa L Von Moltke; David J Greenblatt; Vsevolod E Kostrubsky; Elizabeth H Jeffery; Steven A Wrighton; Frank J Gonzalez; Peter R Sinclair; Jacqueline F Sinclair
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1223-31.
2007: Nadia Gorman; Heidi S Trask; Susan W Robinson; Jacqueline F Sinclair; Glenn S Gerhard; Andrew G Smith; Peter R Sinclair
Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.
Toxicology and applied pharmacology 2007;221(2):235-42.
2007: Nadia Gorman; Adrian Zaharia; Heidi S Trask; Juliana G Szakacs; Nicholas J Jacobs; Judith M Jacobs; Dominic Balestra; Jacqueline F Sinclair; Peter R Sinclair
Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.
Hepatology (Baltimore, Md.) 2007;45(1):187-94.
2006: Trisha L Noreault-Conti; Judith M Jacobs; Heidi W Trask; Steven A Wrighton; Jacqueline F Sinclair; Ralph C Nichols
Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.
Toxicology and applied pharmacology 2006;217(3):245-51.
2006: H C Yohe; Tamar J Kitzmiller; William J Bement; B E Dwyer; Jacqueline F Sinclair
Reduced inflammatory potential of peritoneal macrophages recruited in mice pretreated with a glycolipid synthesis inhibitor.
Inflammopharmacology 2006;14(3-4):170-5.
2006: Herbert C Yohe; Kimberley A O'Hara; Jane A Hunt; Tamar J Kitzmiller; Sheryl G Wood; Jenna L Bement; William J Bement; Juliana G Szakacs; Steven A Wrighton; Judith M Jacobs; Vsevolod E Kostrubsky; Peter R Sinclair; Jacqueline F Sinclair
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1269-79.
2005: Kristina K Wolf; Sheryl G Wood; Jane A Hunt; Brooke W Walton-Strong; Kazuto Yasuda; Lubin Lan; Su X Duan; Qin Hao; Steven A Wrighton; Elizabeth H Jeffery; Ronald M Evans; Juliana G Szakacs; Lisa L Von Moltke; David J Greenblatt; Michael H Court; Erin G Schuetz; Peter R Sinclair; Jacqueline F Sinclair
Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1827-36.
2005: Trisha L Noreault; Judith M Jacobs; Ralph C Nichols; Heidi W Trask; Steven A Wrighton; Peter R Sinclair; Ronald M Evans; Jacqueline F Sinclair
Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.
Toxicology and applied pharmacology 2005;209(2):174-82.
2005: Seva E Kostrubsky; Jacqueline F Sinclair; Stephen C Strom; Sheryl Wood; Ellen Urda; Donna B Stolz; Yuan Hua Wen; Shaila Kulkarni; Abdul E Mutlib
Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(1):146-55.
2005: Trisha L Noreault; Judith M Jacobs; Ralph C Nichols; Heidi W Trask; Steven A Wrighton; Peter R Sinclair; Jacqueline F Sinclair
Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.
Biochemical and biophysical research communications 2005;333(4):1211-7.
2005: Heidi W Trask; Nadia Gorman; Barney E Dwyer; Nicholas J Jacobs; Judith M Jacobs; Jacqueline F Sinclair; Dominic Balestra; Peter R Sinclair
Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures.
Archives of biochemistry and biophysics 2005;439(1):1-11.
2005: Trisha L Noreault; Vsevolod E Kostrubsky; Sheryl G Wood; Ralph C Nichols; Stephen C Strom; Heidi W Trask; Steven A Wrighton; Ronald M Evans; Judith M Jacobs; Peter R Sinclair; Jacqueline F Sinclair
Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):993-1003.
2004: Nadia Gorman; Heidi W Trask; William J Bement; Juliana G Szakacs; George H Elder; Dominic Balestra; Nicholas J Jacobs; Judith M Jacobs; Jacqueline F Sinclair; Glenn S Gerhard; Peter R Sinclair
Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice.
Hepatology (Baltimore, Md.) 2004;40(4):942-50.
2004: Kristina K Wolf; Sheryl G Wood; Jenna L Bement; Peter R Sinclair; Steven A Wrighton; Elizabeth H Jeffery; Frank J Gonzalez; Jacqueline F Sinclair
Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):681-4.
2003: Vsevolod E Kostrubsky; Stephen C Strom; Janean Hanson; Ellen Urda; Kelly Rose; James Burliegh; Philip Zocharski; Hongbo Cai; Jacqueline F Sinclair; Jasminder Sahi
Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.
Toxicological sciences : an official journal of the Society of Toxicology 2003;76(1):220-8.
2003: Ralph C Nichols; Sandra Cooper; Heidi W Trask; Nadia Gorman; Timothy P Dalton; Daniel W Nebert; Jacqueline F Sinclair; Peter R Sinclair
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Biochemical pharmacology 2003;65(4):545-50.
2003: Peter R Sinclair; Nadia Gorman; Heidi W Trask; William J Bement; Juliana G Szakacs; George H Elder; Dominic Balestra; Jacqueline F Sinclair; Glenn S Gerhard
Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda.
Hepatology (Baltimore, Md.) 2003;37(2):351-8.
2002: Yuan Hua Wen; Jasminder Sahi; Ellen Urda; Shaila Kulkarni; Kelly Rose; Xianxian Zheng; Jacqueline F Sinclair; Hongbo Cai; Stephen C Strom; Vsevolod E Kostrubsky
Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):977-84.
2002: Nadia Gorman; Kerry L Ross; Heidi S Walton; William J Bement; Juliana G Szakacs; Glenn S Gerhard; Timothy P Dalton; Daniel W Nebert; Richard S Eisenstein; Jacqueline F Sinclair; Peter R Sinclair
Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Hepatology (Baltimore, Md.) 2002;35(4):912-21.
2001: C Zaccaro; Sarah M Sweitzer; Sandra Pipino; Nadia Gorman; Peter R Sinclair; Jacqueline F Sinclair; Daniel W Nebert; Francesco De Matteis
Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.
Biochemical pharmacology 2001;61(7):843-9.
2001: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Jacqueline F Sinclair; Glenn S Gerhard; Juliana G Szakacs; Nancy C Andrews; Joanne E Levy
Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.
Hepatology (Baltimore, Md.) 2001;33(2):406-12.
2000: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Juliana G Szakacs; Frank J Gonzalez; Timothy P Dalton; Daniel W Nebert; Jacqueline F Sinclair
Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.
Archives of biochemistry and biophysics 2000;384(2):383-90.
2000: Judith M Jacobs; C Nichols; DE Marek; Nadia Gorman; Heidi S Walton; Peter R Sinclair; Jacqueline F Sinclair
Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.
Toxicology and applied pharmacology 2000;168(3):177-82.
2000: Jacqueline F Sinclair; Juliana G Szakacs; Sheryl G Wood; Heidi S Walton; Jenna L Bement; Frank J Gonzalez; Elizabeth H Jeffery; Steven A Wrighton; William J Bement; Peter R Sinclair
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.
Toxicology and applied pharmacology 2000;168(2):114-22.
2000: Vsevolod E Kostrubsky; Jacqueline F Sinclair; V Ramachandran; Raman Venkataramanan; Yuan Hua Wen; E Kindt; V Galchev; Kelly Rose; Michael W Sinz; Stephen C Strom
The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1192-7.
2000: Jacqueline F Sinclair; Juliana G Szakacs; Sheryl G Wood; Vsevolod E Kostrubsky; Elizabeth H Jeffery; Steven A Wrighton; William J Bement; D Wright; Peter R Sinclair
Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.
Biochemical pharmacology 2000;59(4):445-54.
2000: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Timothy P Dalton; Jacqueline F Sinclair; Andrew G Smith; Daniel W Nebert
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Toxicology and applied pharmacology 2000;162(1):60-7.
1999: Judith M Jacobs; DE Marek; Heidi S Walton; Peter R Sinclair; Jacqueline F Sinclair
Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes.
Archives of biochemistry and biophysics 1999;371(1):8-14.
1999: Vsevolod E Kostrubsky; V Ramachandran; Raman Venkataramanan; K Dorko; James Esplen; Shuzhong Zhang; Jacqueline F Sinclair; Steven A Wrighton; Stephen C Strom
The use of human hepatocyte cultures to study the induction of cytochrome P-450.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(8):887-94.
1999: Nadia Gorman; Heidi S Walton; William J Bement; CP Honsinger; Juliana G Szakacs; Jacqueline F Sinclair; Peter R Sinclair
Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.
Biochemical pharmacology 1999;58(2):375-82.
1999: Judith M Jacobs; C E Nichols; angeline andrew; DE Marek; Sheryl G Wood; Peter R Sinclair; Steven A Wrighton; Vsevolod E Kostrubsky; Jacqueline F Sinclair
Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes.
Toxicology and applied pharmacology 1999;157(1):51-9.
1998: C A Louis; Sheryl G Wood; Heidi S Walton; Peter R Sinclair; Jacqueline F Sinclair
Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.
Archives of biochemistry and biophysics 1998;360(2):239-47.
1998: Nadia Gorman; Heidi S Walton; Jacqueline F Sinclair; Peter R Sinclair
CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):405-12.
1998: Peter R Sinclair; Nadia Gorman; I B Tsyrlov; U Fuhr; Heidi S Walton; Jacqueline F Sinclair
Uroporphyrinogen oxidation catalyzed by human cytochromes P450.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(10):1019-25.
1998: Vsevolod E Kostrubsky; L D Lewis; Stephen C Strom; Sheryl G Wood; Erin G Schuetz; J D Schuetz; Peter R Sinclair; Steven A Wrighton; Jacqueline F Sinclair
Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.
Archives of biochemistry and biophysics 1998;355(2):131-6.
1998: Peter R Sinclair; Nadia Gorman; Timothy P Dalton; Heidi S Walton; William J Bement; Jacqueline F Sinclair; Andrew G Smith; Daniel W Nebert
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
The Biochemical journal 1998;330 ( Pt 1)():149-53.
1998: Judith M Jacobs; Peter R Sinclair; Jacqueline F Sinclair; Nadia Gorman; Heidi S Walton; Sheryl G Wood; C Nichols
Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.
Toxicology 1998;125(2-3):95-105.
1997: Peter R Sinclair; Heidi S Walton; Nadia Gorman; Judith M Jacobs; Jacqueline F Sinclair
Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes.
Toxicology and applied pharmacology 1997;147(2):171-9.
1997: Peter R Sinclair; Nadia Gorman; S I Shedlofsky; CP Honsinger; Jacqueline F Sinclair; M R Karagas; Karl E Anderson
Ascorbic acid deficiency in porphyria cutanea tarda.
The Journal of laboratory and clinical medicine 1997;130(2):197-201.
1997: Peter R Sinclair; Nadia Gorman; Heidi S Walton; Jacqueline F Sinclair; C A Lee; A B Rifkind
Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(7):779-83.
1997: Vsevolod E Kostrubsky; Juliana G Szakacs; Elizabeth H Jeffery; Sheryl G Wood; William J Bement; Steven A Wrighton; Peter R Sinclair; Jacqueline F Sinclair
Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.
Toxicology and applied pharmacology 1997;143(2):315-23.
1997: Vsevolod E Kostrubsky; L D Lewis; Sheryl G Wood; Peter R Sinclair; Steven A Wrighton; Jacqueline F Sinclair
Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone.
Toxicology and applied pharmacology 1997;142(1):79-86.
1997: Vsevolod E Kostrubsky; Juliana G Szakacs; Elizabeth H Jeffery; S G Woods; William J Bement; Steven A Wrighton; Peter R Sinclair; Jacqueline F Sinclair
Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A.
Annals of clinical and laboratory science 1997;27(1):57-62.
1996: Judith M Jacobs; N J Jacobs; C B Kuhn; Nadia Gorman; Franck E Dayan; Stephen O Duke; Jacqueline F Sinclair; Peter R Sinclair
Oxidation of porphyrinogens by horseradish peroxidase and formation of a green pyrrole pigment.
Biochemical and biophysical research communications 1996;227(1):195-9.
1995: Vsevolod E Kostrubsky; Sheryl G Wood; M D Bush; Juliana G Szakacs; William J Bement; Peter R Sinclair; Elizabeth H Jeffery; Jacqueline F Sinclair
Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.
Biochemical pharmacology 1995;50(11):1743-8.
1995: Vsevolod E Kostrubsky; Stephen C Strom; Sheryl G Wood; Steven A Wrighton; Peter R Sinclair; Jacqueline F Sinclair
Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes.
Archives of biochemistry and biophysics 1995;322(2):516-20.
1995: Peter R Sinclair; Nadia Gorman; Jacqueline F Sinclair; Heidi S Walton; William J Bement; R W Lambrecht
Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats.
Hepatology (Baltimore, Md.) 1995;22(2):565-72.
1994: Peter R Sinclair; Nadia Gorman; Heidi S Walton; Jacqueline F Sinclair; Judith M Jacobs; N J Jacobs
Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(7):891-7.
1994: Peter R Sinclair; William J Bement; John Healey; Nadia Gorman; Jacqueline F Sinclair; H L Bonkovsky; H H Liem; U Muller-Eberhard
Effects of hemopexin on heme-mediated repression of 5-aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes.
Hepatology (Baltimore, Md.) 1994;20(3):741-6.
1994: C A Louis; Sheryl G Wood; Vsevolod E Kostrubsky; Peter R Sinclair; Jacqueline F Sinclair
Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol.
The Journal of pharmacology and experimental therapeutics 1994;269(2):838-45.
1993: Peter R Sinclair; Nadia Gorman; Heidi S Walton; William J Bement; Judith M Jacobs; Jacqueline F Sinclair
Ascorbic acid inhibition of cytochrome P450-catalyzed uroporphyrin accumulation.
Archives of biochemistry and biophysics 1993;304(2):464-70.
1993: C A Louis; Jacqueline F Sinclair; Sheryl G Wood; L K Lambrecht; Peter R Sinclair; E L Smith
Synergistic induction of cytochrome P450 by ethanol and isopentanol in cultures of chick embryo and rat hepatocytes.
Toxicology and applied pharmacology 1993;118(2):169-76.
1992: Jacqueline F Sinclair; B K Schaeffer; Sheryl G Wood; L K Lambrecht; Nadia Gorman; William J Bement; E L Smith; Peter R Sinclair; Charles A Waldren
2-Amino-3,4-dimethylimidazo[4,5-f]quinoline induces and inhibits cytochrome P450 from the IA subfamily in chick and rat hepatocytes.
Cancer research 1992;52(13):3615-21.
1992: R W Lambrecht; Peter R Sinclair; Nadia Gorman; Jacqueline F Sinclair
Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.
Archives of biochemistry and biophysics 1992;294(2):504-10.
1992: Judith M Jacobs; Peter R Sinclair; Nadia Gorman; N J Jacobs; Jacqueline F Sinclair; William J Bement; Heidi S Walton
Effects of diphenyl ether herbicides on porphyrin accumulation by cultured hepatocytes.
Journal of biochemical toxicology 1992;7(2):87-95.
1991: Jacqueline F Sinclair; J McCaffrey; Peter R Sinclair; William J Bement; L K Lambrecht; Sheryl G Wood; E L Smith; J B Schenkman; P S Guzelian; S S Park
Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.
Archives of biochemistry and biophysics 1991;284(2):360-5.
1990: Peter R Sinclair; E G Schuetz; William J Bement; S A Haugen; Jacqueline F Sinclair; B K May; D Li; P S Guzelian
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix.
Archives of biochemistry and biophysics 1990;282(2):386-92.
1990: Peter R Sinclair; William J Bement; R W Lambrecht; Nadia Gorman; Jacqueline F Sinclair
Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytes.
Archives of biochemistry and biophysics 1990;281(2):225-32.
1990: Jacqueline F Sinclair; S Wood; L Lambrecht; Nadia Gorman; L Mende-Mueller; L Smith; J Hunt; P Sinclair
Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by h.p.l.c. and their enzymic characterization.
The Biochemical journal 1990;269(1):85-91.
1990: Peter R Sinclair; Judith M Jacobs; S M Deam; R W Lambrecht; Jacqueline F Sinclair; George H Elder
Relationship between lucigenin-enhanced chemiluminescence and uroporphyrinogen oxidation in mouse and chick embryo liver microsomes.
Biochemical pharmacology 1990;39(11):1828-30.
1990: A M Standeven; Yuenian Shi; Jacqueline F Sinclair; Peter R Sinclair; James D Yager
Metabolism of the liver tumor promoter ethinyl estradiol by primary cultures of rat hepatocytes.
Toxicology and applied pharmacology 1990;102(3):486-96.
1990: Judith M Jacobs; Peter R Sinclair; R W Lambrecht; Jacqueline F Sinclair; N J Jacobs
Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidation.
Journal of biochemical toxicology 1990;5(3):193-9.
1989: Peter R Sinclair; William J Bement; R W Lambrecht; Judith M Jacobs; Jacqueline F Sinclair
Uroporphyria caused by acetone and 5-aminolevulinic acid in iron-loaded mice.
Biochemical pharmacology 1989;38(23):4341-4.
1989: Judith M Jacobs; Peter R Sinclair; R W Lambrecht; Jacqueline F Sinclair
Effects of iron-EDTA on uroporphyrinogen oxidation by liver microsomes.
FEBS letters 1989;250(2):349-52.
1989: Judith M Jacobs; Peter R Sinclair; William J Bement; R W Lambrecht; Jacqueline F Sinclair; J A Goldstein
Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d.
The Biochemical journal 1989;258(1):247-53.
1989: Jacqueline F Sinclair; Sheryl G Wood; E L Smith; Peter R Sinclair; Dennis R Koop
Comparison of the form(s) of cytochrome P-450 induced by ethanol and glutethimide in cultured chick hepatocytes.
Biochemical pharmacology 1989;38(4):657-64.
1988: R W Lambrecht; Peter R Sinclair; William J Bement; Jacqueline F Sinclair
Uroporphyrin accumulation in cultured chick embryo hepatocytes: comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,4,3',4'-tetrachlorobiphenyl.
Toxicology and applied pharmacology 1988;96(3):507-16.
1988: R W Lambrecht; Peter R Sinclair; William J Bement; Jacqueline F Sinclair; H M Carpenter; D R Buhler; A J Urquhart; George H Elder
Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds.
The Biochemical journal 1988;253(1):131-8.
1988: S A Sundstrom; Jacqueline F Sinclair; E L Smith; Peter R Sinclair
Effect of 17 alpha-ethynylestradiol on the induction of cytochrome P-450 by 3-methylcholanthrene in cultured chick embryo hepatocytes.
Biochemical pharmacology 1988;37(6):1003-8.
1987: Herbert L Bonkovsky; Peter R Sinclair; William J Bement; R W Lambrecht; Jacqueline F Sinclair
Role of cytochrome P-450 in porphyria caused by halogenated aromatic compounds.
Annals of the New York Academy of Sciences 1987;514():96-112.
1986: Peter R Sinclair; William J Bement; Herbert L Bonkovsky; R W Lambrecht; J E Frezza; Jacqueline F Sinclair; A J Urquhart; George H Elder
Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide.
The Biochemical journal 1986;237(1):63-71.
1986: Peter R Sinclair; Jacqueline F Sinclair; William J Bement; R W Lambrecht; Herbert L Bonkovsky
Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds.
IARC scientific publications 1986;(77):535-42.
1984: H L Bonkovsky; John Healey; William J Bement; Peter R Sinclair; Jacqueline F Sinclair; Steven I Shedlofsky
Effect of uroporphyrin on the spectral measurement of cytochrome P450.
Biochemical pharmacology 1984;33(3):499-502.
1983: Steven I Shedlofsky; H L Bonkowsky; Peter R Sinclair; Jacqueline F Sinclair; William J Bement; J S Pomeroy
Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation.
The Biochemical journal 1983;212(2):321-30.
1983: H L Bonkowsky; John Healey; Peter R Sinclair; Jacqueline F Sinclair; Steven I Shedlofsky; G H Elder
Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.
The Journal of clinical investigation 1983;71(5):1175-82.
1983: Peter R Sinclair; G H Elder; William J Bement; S G Smith; H L Bonkowsky; Jacqueline F Sinclair
Decreased activity of uroporphyrinogen decarboxylase caused by 2,4,5,3',4'-pentabromobiphenyl in chick embryo hepatocyte cultures. Difference in activity in intact or homogenized cells.
FEBS letters 1983;152(2):217-21.
1982: Jacqueline F Sinclair; L Smith; William J Bement; Peter R Sinclair; H L Bonkowsky
Increases in cytochrome p-450 in cultured hepatocytes mediated by 3- and 4-carbon alcohols.
Biochemical pharmacology 1982;31(17):2811-5.
1982: Jacqueline F Sinclair; Peter R Sinclair; John Healey; E L Smith; H L Bonkowsky
Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin.
The Biochemical journal 1982;204(1):103-9.
1982: Peter R Sinclair; Jacqueline F Sinclair; H L Bonkowsky; A H Gibbs; F De Matteis
Formation of cobalt protoporphyrin by chicken hepatocytes in culture. Relationship to decrease of 5-aminolaevulinate synthase caused by cobalt.
Biochemical pharmacology 1982;31(6):993-9.
1981: Peter R Sinclair; John Healey; Jacqueline F Sinclair; H L Bonkowsky
Induction of 5-aminolaevulinate synthase in chick embryo liver by propylisopropylacetamide does not involve destruction of cytochrome P-450.
The Biochemical journal 1981;200(3):709-10.
1981: Jacqueline F Sinclair; Peter R Sinclair; E L Smith; W J Bement; J Pomeroy; H Bonkowsky
Ethanol-mediated increase in cytochrome P-450 in cultured hepatocytes.
Biochemical pharmacology 1981;30(20):2805-9.
1981: John Healey; H L Bonkowsky; Peter R Sinclair; Jacqueline F Sinclair
Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryo.
The Biochemical journal 1981;198(3):595-604.
1981: H L Bonkowsky; John Healey; Peter R Sinclair; Jacqueline F Sinclair; J S Pomeroy
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
The Biochemical journal 1981;196(1):57-64.
1981: I Okazaki; C E Brinckerhoff; Jacqueline F Sinclair; Peter R Sinclair; H L Bonkowsky; E D Harris
Iron increases collagenase production by rabbit synovial fibroblasts.
The Journal of laboratory and clinical medicine 1981;97(3):396-402.
1980: H L Bonkowsky; Peter R Sinclair; S Emery; Jacqueline F Sinclair
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Neurology 1980;30(6):588-92.