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Michael Sinensky

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June Liu; Courtney Netherland; Theresa Pickle; Michael S Sinensky; Douglas P Thewke
Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.
Yiyong Liu; Youjie Wang; Antonio Rusiñol; Michael S Sinensky; Ji Liu; Steven M Shell; Yue Zou
Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.
Thomas Dechat; Takeshi Shimi; Stephen Adam; Antonio Rusiñol; Douglas A Andres; H Peter Spielmann; Michael S Sinensky; Robert D Goldman
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.

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All Publications

2009: June Liu; Courtney Netherland; Theresa Pickle; Michael S Sinensky; Douglas P Thewke
Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.
Archives of biochemistry and biophysics 2009;487(1):54-8.
2008: Yiyong Liu; Youjie Wang; Antonio Rusiñol; Michael S Sinensky; Ji Liu; Steven M Shell; Yue Zou
Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):603-11.
2007: Thomas Dechat; Takeshi Shimi; Stephen Adam; Antonio Rusiñol; Douglas A Andres; H Peter Spielmann; Michael S Sinensky; Robert D Goldman
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):4955-60.
2006: Yiyong Liu; Antonio Rusiñol; Michael S Sinensky; Youjie Wang; Yue Zou
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Journal of cell science 2006;119(Pt 22):4644-9.
2006: Antonio Rusiñol; Michael S Sinensky
Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors.
Journal of cell science 2006;119(Pt 16):3265-72.
2005: Natalie E Freeman; Antonio Rusiñol; MacRae F Linton; David L Hachey; Sergio Fazio; Michael S Sinensky; Douglas P Thewke
Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages.
Journal of lipid research 2005;46(9):1933-43.
2005: Douglas P Corrigan; Danuta Kuszczak; Antonio Rusiñol; Douglas P Thewke; Christine A Hrycyna; Susan Michaelis; Michael S Sinensky
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.
The Biochemical journal 2005;387(Pt 1):129-38.
2005: June Liu; Douglas P Thewke; Yan Ru Su; MacRae F Linton; Sergio Fazio; Michael S Sinensky
Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):174-9.
2004: Antonio Rusiñol; Douglas P Thewke; June Liu; Natalie Freeman; Sankhavaram R Panini; Michael S Sinensky
AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.
The Journal of biological chemistry 2004;279(2):1392-9.
2002: Michael S Sinensky
Lipids and me.
Biochemical and biophysical research communications 2002;292(5):1279-81.
2001: Sankhavaram R Panini; Likui Yang; Antonio Rusiñol; Michael S Sinensky; J V Bonventre; C C Leslie
Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol.
Journal of lipid research 2001;42(10):1678-86.
2001: Sankhavaram R Panini; Michael S Sinensky
Mechanisms of oxysterol-induced apoptosis.
Current opinion in lipidology 2001;12(5):529-33.
2000: Michael S Sinensky
Functional aspects of polyisoprenoid protein substituents: roles in protein-protein interaction and trafficking.
Biochimica et biophysica acta 2000;1529(1-3):203-9.
2000: Likui Yang; Michael S Sinensky
25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade.
Biochemical and biophysical research communications 2000;278(3):557-63.
2000: Douglas P Thewke; M Kramer; Michael S Sinensky
Transcriptional homeostatic control of membrane lipid composition.
Biochemical and biophysical research communications 2000;273(1):1-4.
2000: Michael S Sinensky
Recent advances in the study of prenylated proteins.
Biochimica et biophysica acta 2000;1484(2-3):93-106.
2000: Antonio Rusiñol; Likui Yang; Douglas P Thewke; Sankhavaram R Panini; M F Kramer; Michael S Sinensky
Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein.
The Journal of biological chemistry 2000;275(10):7296-303.
1999: Fusun Kilic; D A Johnson; Michael S Sinensky
Subcellular localization and partial purification of prelamin A endoprotease: an enzyme which catalyzes the conversion of farnesylated prelamin A to mature lamin A.
FEBS letters 1999;450(1-2):61-5.
1998: Douglas P Thewke; Sankhavaram R Panini; Michael S Sinensky
Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins.
The Journal of biological chemistry 1998;273(33):21402-7.
1998: Afzal A Siddiqui; J R Garland; M B Dalton; Michael S Sinensky
Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes.
The Journal of biological chemistry 1998;273(6):3712-7.
1997: Fusun Kilic; J Salas-Marco; J Garland; Michael S Sinensky
Regulation of prelamin A endoprotease activity by prelamin A.
FEBS letters 1997;414(1):65-8.
1997: Fusun Kilic; M B Dalton; S K Burrell; J P Mayer; S D Patterson; Michael S Sinensky
In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease.
The Journal of biological chemistry 1997;272(8):5298-304.
1997: Afzal A Siddiqui; N M Koenig; Michael S Sinensky; SL Berk
Strongyloides stercoralis: identification of antigens in natural human infections from endemic areas of the United States.
Parasitology research 1997;83(7):655-8.
1995: M B Dalton; K S Fantle; H A Bechtold; L DeMaio; R M Evans; A Krystosek; Michael S Sinensky
The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization.
Cancer research 1995;55(15):3295-304.
1995: M Dalton; Michael S Sinensky
Expression systems for nuclear lamin proteins: farnesylation in assembly of nuclear lamina.
Methods in enzymology 1995;250():134-48.
1994: Michael S Sinensky; T McLain; K Fantle
Expression of prelamin A but not mature lamin A confers sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells.
Journal of cell science 1994;107 ( Pt 8)():2215-8.
1994: Michael S Sinensky; K Fantle; M Dalton
An antibody which specifically recognizes prelamin A but not mature lamin A: application to detection of blocks in farnesylation-dependent protein processing.
Cancer research 1994;54(12):3229-32.
1994: Michael S Sinensky; K Fantle; M Trujillo; T McLain; Abraham Kupfer; M Dalton
The processing pathway of prelamin A.
Journal of cell science 1994;107 ( Pt 1)():61-7.
1992: Roya Khosravi-Far; Geoffrey J Clark; K Abe; Adrienne D Cox; T McLain; R J Lutz; Michael S Sinensky; Channing J Der
Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.
The Journal of biological chemistry 1992;267(34):24363-8.
1992: S R Panini; T A Delate; Michael S Sinensky
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol.
The Journal of biological chemistry 1992;267(18):12647-54.
1992: R J Lutz; T M McLain; Michael S Sinensky
Feedback inhibition of polyisoprenyl pyrophosphate synthesis from mevalonate in vitro. Implications for protein prenylation.
The Journal of biological chemistry 1992;267(12):7983-6.
1992: R J Lutz; M A Trujillo; K S Denham; L Wenger; Michael S Sinensky
Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3000-4.
1992: Michael S Sinensky; R J Lutz
The prenylation of proteins.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(1):25-31.
1991: Roya Khosravi-Far; R J Lutz; Adrienne D Cox; L Conroy; J R Bourne; Michael S Sinensky; William E Balch; Janice E Buss; Channing J Der
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6264-8.
1990: Michael S Sinensky; L A Beck; S Leonard; R Evans
Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis.
The Journal of biological chemistry 1990;265(32):19937-41.
1990: S R Panini; R J Lutz; L Wenger; J Miyake; S Leonard; A Andalibi; A J Lusis; Michael S Sinensky
Defective elongation of fatty acids in a recessive 25-hydroxycholesterol-resistant mutant cell line.
The Journal of biological chemistry 1990;265(24):14118-26.
1990: L A Beck; T J Hosick; Michael S Sinensky
Isoprenylation is required for the processing of the lamin A precursor.
The Journal of cell biology 1990;110(5):1489-99.
1990: S Leonard; L Beck; Michael S Sinensky
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
The Journal of biological chemistry 1990;265(9):5157-60.
1989: S R Panini; R Schnitzer-Polokoff; Thomas A Spencer; Michael S Sinensky
Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity.
The Journal of biological chemistry 1989;264(19):11044-52.
1989: C F von Gunten; Michael S Sinensky
Treatment of CHO-K1 cells with 25-hydroxycholesterol produces a more rapid loss of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity than can be accounted for by enzyme turnover.
Biochimica et biophysica acta 1989;1001(2):218-24.
1988: D Peffley; J Miyake; S Leonard; C von Gunten; Michael S Sinensky
Further characterization of a somatic cell mutant defective in regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Somatic cell and molecular genetics 1988;14(6):527-39.
1988: L A Beck; T J Hosick; Michael S Sinensky
Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.
The Journal of cell biology 1988;107(4):1307-16.
1988: S Leonard; Michael S Sinensky
Somatic cell genetics and the study of cholesterol metabolism.
Biochimica et biophysica acta 1988;947(1):101-12.
1987: E Burki; J Logel; Michael S Sinensky
Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein.
Journal of lipid research 1987;28(10):1199-205.
1987: R Schnitzer-Polokoff; Michael S Sinensky
Characterization of HMG CoA synthase activity of rat liver and CHO-K1 cells.
Journal of cellular biochemistry 1987;35(2):93-103.
1987: Michael S Sinensky; J Logel; S Phirwa; A K Gayen; Thomas A Spencer
Requirement for 24(S),25-epoxycholesterol for the viability of cultured fibroblasts.
Experimental cell research 1987;171(2):492-7.
1987: C von Gunten; J Leighton; D Peffley; Michael S Sinensky
Progress in understanding mechanisms of the serum cholesterol risk factor in atherosclerosis.
Somatic cell and molecular genetics 1987;13(4):469-77.
1985: D Peffley; Michael S Sinensky
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control.
The Journal of biological chemistry 1985;260(18):9949-52.
1985: Michael S Sinensky; J Logel; R Schnitzer-Polokoff; R A Norcross
A somatic cell mutant with a kinetically altered 3-hydroxy-3-methylglutaryl coenzyme A reductase.
FEBS letters 1985;186(2):219-23.
1985: Michael S Sinensky; J Logel
Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(10):3257-61.
1983: R Schnitzer-Polokoff; R Torget; J Logel; Michael S Sinensky
Analysis of the coordinate expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities in Chinese hamster ovary fibroblasts.
Archives of biochemistry and biophysics 1983;227(1):71-80.
1983: Michael S Sinensky; J Logel
Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.
The Journal of biological chemistry 1983;258(14):8547-9.
1982: Michael S Sinensky; J Logel; R Torget
Complementary recessive 25-hydroxycholesterol-resistant somatic cell mutants--assay of 25-hydroxycholesterol binding activity.
Journal of cellular physiology 1982;113(2):314-9.
1982: Michael S Sinensky; R Torget; R Schnitzer-Polokoff; P A Edwards
Analysis of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant auxotrophic for mevalonate.
The Journal of biological chemistry 1982;257(13):7284-6.
1982: R Schnitzer-Polokoff; C von Gunten; J Logel; R Torget; Michael S Sinensky
Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase.
The Journal of biological chemistry 1982;257(1):472-6.
1981: Michael S Sinensky; R Torget; P A Edwards
Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.
The Journal of biological chemistry 1981;256(22):11774-9.
1981: Michael S Sinensky; G Mueller
Cytosolic 25-hydroxycholesterol binding activity of Chinese hamster ovary cells.
Archives of biochemistry and biophysics 1981;209(1):314-20.
1980: Michael S Sinensky; S Armagast; G Mueller; R Torget
Somatic cell genetic analysis of regulation of expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(11):6621-3.