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Roshni Singaraja

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Lipoylation

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Roshni R Singaraja; Suthesh Sivapalaratnam; Ian Tietjen; Mieke D Trip; Cornelia van Duijn; Margaret van Heek; Leonie van Vark-van der Zee; Germaine Verwoert; Michael Winther; Kenny Wong; Albert Hofman; Kees Hovingh; Brian Hubbard; John J Kastelein; Ulf Landmesser; Linus Lin; Jasmin Manz; A David Marais; Jason McEwen; Lyndon J Mitnaul; Meliana Riwanto; Thomas A Roddy; Eric Sijbrands; Steven J Adelman; Bela Asztalos; José Castro-Perez; Heidi L Collins; Geesje Dallinge-Thie; Marie-Pierre Dubé; Michael R Hayden
The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Liza M Sutton; Fiona B Young; Weining Zhang; Stefanie L Butland; Crystal N Doty; Sonia Franciosi; Vlad Kovalik; Katherine K N Mui; Shaun S Sanders; Mandi E Schmidt; Roshni R Singaraja; Amber L Southwell; Michael R Hayden
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Ian Tietjen; Amina Barhdadi; Elden Chan; Marie-Pierre Dubé; Patrick L Franchini; G Kees Hovingh; John J P Kastelein; Annick Legendre; Maryanne Mattice; Jason McEwen; Christopher C Radomski; Roshni R Singaraja; Michael R Hayden
Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol.

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All Publications

2013: Roshni R Singaraja; Suthesh Sivapalaratnam; Ian Tietjen; Mieke D Trip; Cornelia van Duijn; Margaret van Heek; Leonie van Vark-van der Zee; Germaine Verwoert; Michael Winther; Kenny Wong; Albert Hofman; Kees Hovingh; Brian Hubbard; John J Kastelein; Ulf Landmesser; Linus Lin; Jasmin Manz; A David Marais; Jason McEwen; Lyndon J Mitnaul; Meliana Riwanto; Thomas A Roddy; Eric Sijbrands; Steven J Adelman; Bela Asztalos; José Castro-Perez; Heidi L Collins; Geesje Dallinge-Thie; Marie-Pierre Dubé; Michael R Hayden
The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Circulation. Cardiovascular genetics 2013;6(1):54-62.
2013: Liza M Sutton; Fiona B Young; Weining Zhang; Stefanie L Butland; Crystal N Doty; Sonia Franciosi; Vlad Kovalik; Katherine K N Mui; Shaun S Sanders; Mandi E Schmidt; Roshni R Singaraja; Amber L Southwell; Michael R Hayden
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Human molecular genetics 2013;22(3):452-65.
2012: Ian Tietjen; Amina Barhdadi; Elden Chan; Marie-Pierre Dubé; Patrick L Franchini; G Kees Hovingh; John J P Kastelein; Annick Legendre; Maryanne Mattice; Jason McEwen; Christopher C Radomski; Roshni R Singaraja; Michael R Hayden
Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol.
PloS one 2012;7(8):e37437.
2012: Fiona B Young; Weining Zhang; Nagat Bissada; Yu Deng; Sonia Franciosi; Kun Huang; Chris Kay; Shaun Sanders; Roshni R Singaraja; Amanda Spreeuw; Natalie C M Tam; Michael R Hayden
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.
PloS one 2012;7(5):e36315.
2011: Roshni R Singaraja; Kuljeet Vaid; Junmei Wan; Fiona B Young; Nagat Bissada; Nicholas G Davis; Crystal Doty; Renaldo C Drisdel; Sonia Franciosi; William N Green; R Mark Henkelman; Rochelle Hines; Kun Huang; Jason P Lerch; Austen J Milnerwood; Lynn A Raymond; Shaun S Sanders; Michael R Hayden
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Human molecular genetics 2011;20(20):3899-909.
2011: Kun Huang; Rujun Kang; Lili Liu; Shaun S Sanders; Roshni R Singaraja; Liza Sutton; Junmei Wan; Fiona B Young; Jeffrey B Carroll; Nicholas G Davis; Alaa El-Husseini; Michael R Hayden
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Human molecular genetics 2011;20(17):3356-65.
2011: Dan Ye; Ying Zhao; Reeni B Hildebrand; Roshni R Singaraja; Michael R Hayden; Theo Van berkel; Miranda van Eck
The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice.
The American journal of pathology 2011;178(1):413-22.
2010: Soonkyu Chung; Jenelle M Timmins; MyNgan Duong; Chiara Degirolamo; Shunxing Rong; Janet K Sawyer; Roshni R Singaraja; Michael R Hayden; Nobuyo Maeda; Lawrence L Rudel; Gregory S Shelness; John S Parks
Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
The Journal of biological chemistry 2010;285(16):12197-209.
2010: Martin H Kang; Roshni R Singaraja; Michael R Hayden
Adenosine-triphosphate-binding cassette transporter-1 trafficking and function.
Trends in cardiovascular medicine 2010;20(2):41-9.
2009: Kun Huang; Shaun Sanders; Roshni R Singaraja; Paul Orban; Tony Cijsouw; Pamela Arstikaitis; Anat Yanai; Michael R Hayden; Alaa El-Husseini
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2605-15.
2009: Roshni R Singaraja; Martin H Kang; Kuljeet Vaid; Shaun S Sanders; Gonzalo L Vilas; Pamela Arstikaitis; Jonathan Coutinho; Renaldo C Drisdel; Alaa El Din El-Husseini; William N Green; Luc Berthiaume; Michael R Hayden
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
Circulation research 2009;105(2):138-47.
2009: Liam R Brunham; Roshni R Singaraja; MyNgan Duong; Jenelle M Timmins; Catherine Fievet; Nagat Bissada; Martin H Kang; Amrit Samra; Jean-Charles Fruchart; Bruce McManus; Bart Staels; John S Parks; Michael R Hayden
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):548-54.
2009: Joanna M Karasinska; Franz Rinninger; Dieter Lütjohann; Piers Ruddle; Sonia Franciosi; Janine K Kruit; Roshni R Singaraja; Veronica Hirsch-Reinshagen; Jianjia Fan; Liam R Brunham; Nagat Bissada; Rajasekhar Ramakrishnan; Cheryl L Wellington; John S Parks; Michael R Hayden
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3579-89.
2009: Simon Warby; Crystal N Doty; Graham Kyrenia Rona; Jonathan Shively; Roshni R Singaraja; Michael R Hayden
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
Molecular and cellular neurosciences 2009;40(2):121-7.
2008: Simon Warby; Crystal N Doty; Graham Kyrenia Rona; Jeffrey B Carroll; Yu-Zhou Yang; Roshni R Singaraja; Christopher M Overall; Michael R Hayden
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Human molecular genetics 2008;17(15):2390-404.
2008: Rochelle M Hines; Longjun Wu; Dustin J Hines; Hendrik Steenland; Souraya Mansour; Regina Dahlhaus; Roshni R Singaraja; Xiaoyan Cao; Esther Sammler; Sheriar G Hormuzdi; Min Zhuo; Alaa El-Husseini
Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(24):6055-67.
2008: Marcia L E MacDonald; Roshni R Singaraja; Nagat Bissada; Piers Ruddle; Russell Watts; Joanna M Karasinska; William T Gibson; Catherine Fievet; Jean E Vance; Bart Staels; Michael R Hayden
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.
Journal of lipid research 2008;49(1):217-29.
2007: Kuljeet S Vaid; Julian A Guttman; Roshni R Singaraja; A Wayne Vogl
A kinesin is present at unique sertoli/spermatid adherens junctions in rat and mouse testes.
Biology of reproduction 2007;77(6):1037-48.
2007: Marta Valenza; Jeffrey B Carroll; Valerio Leoni; Lisa N Bertram; Ingeman Björkhem; Roshni R Singaraja; Stefano Di Donato; Dieter Lutjohann; Michael R Hayden; Elena Cattaneo
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
Human molecular genetics 2007;16(18):2187-98.
2007: Veronica Hirsch-Reinshagen; Jeniffer Y Chan; Anna Wilkinson; Tracie Tanaka; Jianjia Fan; George Ou; Luis F Maia; Roshni R Singaraja; Michael R Hayden; Cheryl L Wellington
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.
Journal of lipid research 2007;48(4):914-23.
2006: Roshni R Singaraja; Miranda van Eck; Nagat Bissada; Francesca Zimetti; Heidi L Collins; Reeni B Hildebrand; Anna Hayden; Liam R Brunham; Martin H Kang; Jean-Charles Fruchart; Theo Van berkel; John S Parks; Bart Staels; George H Rothblat; Catherine Fiévet; Michael R Hayden
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Circulation 2006;114(12):1301-9.
2006: Roshni R Singaraja; Henk Visscher; Erick R James; Angeliki Chroni; Jonathan M Coutinho; Liam R Brunham; Martin H Kang; Vassilis I Zannis; Giovanna Chimini; Michael R Hayden
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
Circulation research 2006;99(4):389-97.
2006: Roshni R Singaraja; Bjorn Stahmer; May Brundert; Martin Merkel; Joerg Heeren; Nagat Bissada; Martin Kang; Jenelle M Timmins; Rajasekhar Ramakrishnan; John S Parks; Michael R Hayden; Franz Rinninger
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1821-7.
2006: Anat Yanai; Kun Huang; Rujun Kang; Roshni R Singaraja; Pamela Arstikaitis; Lu Gan; Paul C Orban; Asher Mullard; Catherine M Cowan; Lynn A Raymond; Renaldo C Drisdel; William N Green; Brinda Ravikumar; David C Rubinsztein; Alaa El-Husseini; Michael R Hayden
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience 2006;9(6):824-31.
2006: Miranda van Eck; Roshni R Singaraja; Dan Ye; Reeni B Hildebrand; Erick R James; Michael R Hayden; Theo Van berkel
Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):929-34.
2006: Liam R Brunham; Roshni R Singaraja; Michael R Hayden
Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.
Annual review of nutrition 2006;26():105-29.
2005: Liam R Brunham; Roshni R Singaraja; Terry D Pape; Anish Kejariwal; Paul D Thomas; Michael R Hayden
Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene.
PLoS genetics 2005;1(6):e83.
2005: Roshni R Singaraja; Erick R James; Jennifer Crim; Henk Visscher; Alu Chatterjee; Michael R Hayden
Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1.
Journal of lipid research 2005;46(10):2061-71.
2005: Simon Warby; Edmond Y W Chan; Martina Metzler; Lu Gan; Roshni R Singaraja; Susan F Crocker; Harold A Robertson; Michael R Hayden
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Human molecular genetics 2005;14(11):1569-77.
2005: Jonathan M Coutinho; Roshni R Singaraja; Martin Kang; David J Arenillas; Lisa N Bertram; Nagat Bissada; Bart Staels; Jean-Charles Fruchart; Catherine Fievet; Ann M Joseph-George; Wyeth W Wasserman; Michael R Hayden
Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis.
Journal of lipid research 2005;46(6):1113-23.
2004: Kun Huang; Anat Yanai; Rujun Kang; Pamela Arstikaitis; Roshni R Singaraja; Martina Metzler; Asher Mullard; Brendan Haigh; Catherine Gauthier-Campbell; Claire-Anne Gutekunst; Michael R Hayden; Alaa El-Husseini
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Neuron 2004;44(6):977-86.
2004: Evan Hermel; Juliette Gafni; Stephanie Propp; Blair R Leavitt; Cheryl L Wellington; Jessica E Young; Abigail S Hackam; Anna Logvinova; Alyson Peel; Sylvia F Chen; Vivian Y H Hook; Roshni R Singaraja; Stan Krajewski; Paul Goldsmith; H Michael Ellerby; Michael R Hayden; Dale E Bredesen; Lisa M Ellerby
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell death and differentiation 2004;11(4):424-38.
2003: Roshni R Singaraja; Liam R Brunham; Henk Visscher; John J P Kastelein; Michael R Hayden
Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1322-32.
2003: Cheryl L Wellington; Liam R Brunham; Steven Zhou; Roshni R Singaraja; Henk Visscher; Allison Gelfer; Colin Ross; Erick James; Guoqing Liu; Mary T Huber; Yu-Zhou Yang; Robin J Parks; Albert Groen; Jamila Fruchart-Najib; Michael R Hayden
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.
Journal of lipid research 2003;44(8):1470-80.
2002: Cheryl L Wellington; Yu-Zhou Yang; Stephen Zhou; Susanne M Clee; Bing Tan; Kenichi Hirano; Karin Zwarts; Anita Kwok; Allison Gelfer; Michel Marcil; Scott Newman; Kirsten Roomp; Roshni R Singaraja; Jennifer Collins; Lin-Hua Zhang; Albert K Groen; Kees Hovingh; Alison Brownlie; Sherrie R Tafuri; Jacques Genest; John J P Kastelein; Michael R Hayden
Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.
Journal of lipid research 2002;43(11):1939-49.
2002: Roshni R Singaraja; Shinji Hadano; Martina Metzler; Scott Givan; Cheryl L Wellington; Simon Warby; Anat Yanai; Claire-Anne Gutekunst; Blair R Leavitt; Hong Yi; Keith Fichter; Lu Gan; Krista McCutcheon; Vikramjit Chopra; Jennifer Michel; Steven M Hersch; Joh-E Ikeda; Michael R Hayden
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics 2002;11(23):2815-28.
2002: Raymond H See; Rosalinda A Caday-Malcolm; Roshni R Singaraja; Steven Zhou; Anthony Silverston; Mary T Huber; Josh Moran; Erick R James; Rozmin Janoo; Jane M Savill; Veronique Rigot; Lin-Hua Zhang; Minghan Wang; Giovanna Chimini; Cheryl L Wellington; Sherrie R Tafuri; Michael R Hayden
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
The Journal of biological chemistry 2002;277(44):41835-42.
2002: Alan D Attie; Yannick Hamon; Angela R Brooks-Wilson; Mark P Gray-Keller; Marcia L E MacDonald; Veronique Rigot; Angie Tebon; Lin-Hua Zhang; Jacob D Mulligan; Roshni R Singaraja; J James Bitgood; Mark E Cook; John J P Kastelein; Giovanna Chimini; Michael R Hayden
Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.
Journal of lipid research 2002;43(10):1610-7.
2002: Johane Robitaille; Marcia L E MacDonald; Ajamete Kaykas; Laird C Sheldahl; Jutta Zeisler; Marie-Pierre Dubé; Lin-Hua Zhang; Roshni R Singaraja; Duane L Guernsey; Binyou Zheng; Lee F Siebert; Ann Hoskin-Mott; Michael T Trese; Simon N Pimstone; Barkur S Shastry; Randall T Moon; Michael R Hayden; Y Paul Goldberg; Mark E Samuels
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Nature genetics 2002;32(2):326-30.
2002: Cheryl L Wellington; Lisa M Ellerby; Claire-Anne Gutekunst; Danny Rogers; Simon Warby; Graham Kyrenia Rona; Odell Loubser; Jeremy M van Raamsdonk; Roshni R Singaraja; Yu-Zhou Yang; Juliette Gafni; Dale E Bredesen; Steven M Hersch; Blair R Leavitt; Sophie Roy; Donald W Nicholson; Michael R Hayden
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7862-72.
2002: Roshni R Singaraja; Catherine Fievet; Graciela Castro; Erick R James; Nathalie Hennuyer; Susanne M Clee; Nagat Bissada; Jonathan C Choy; Jean-Charles Fruchart; Bruce M McManus; Bart Staels; Michael R Hayden
Increased ABCA1 activity protects against atherosclerosis.
The Journal of clinical investigation 2002;110(1):35-42.
2002: Cheryl L Wellington; Elizabeth K-Y Walker; Agripina Suarez; Anita Kwok; Nagat Bissada; Roshni R Singaraja; Yu-Zhou Yang; Lin-Hua Zhang; Erick James; Janet E Wilson; Omar L Francone; Bruce M McManus; Michael R Hayden
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation.
Laboratory investigation; a journal of technical methods and pathology 2002;82(3):273-83.
2002: Karin Zwarts; Susanne M Clee; Aeilko H Zwinderman; J C Engert; Roshni R Singaraja; Odell Loubser; Erick James; Kirsten Roomp; T J Hudson; J Wouter Jukema; J J P Kastelein; Michael R Hayden
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
Clinical genetics 2002;61(2):115-25.
2002: François G Gervais; Roshni R Singaraja; Steven Xanthoudakis; Claire-Anne Gutekunst; Blair R Leavitt; Martina Metzler; Abigail S Hackam; John Tam; John P Vaillancourt; Vicky Houtzager; Dita M Rasper; Sophie Roy; Michael R Hayden; Donald W Nicholson
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nature cell biology 2002;4(2):95-105.
2001: Shinji Hadano; Collette K Hand; Hitoshi Osuga; Yoshiko Yanagisawa; Asako Otomo; Rebecca S Devon; N Miyamoto; Junko Showguchi-Miyata; Y Okada; Roshni R Singaraja; D A Figlewicz; T Kwiatkowski; B A Hosler; Tally Lerman-Sagie; Jennifer Skaug; Jamal Nasir; R H Brown; Stephen W Scherer; Guy Rouleau; Michael R Hayden; Joh-E Ikeda
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Nature genetics 2001;29(2):166-73.
2001: Roshni R Singaraja; V Bocher; Erick R James; Susanne M Clee; Lin-Hua Zhang; Blair R Leavitt; B Tan; Angela R Brooks-Wilson; Anita Kwok; Nagat Bissada; Yu-Zhou Yang; Guoqing Liu; Sherrie R Tafuri; Catherine Fievet; Cheryl L Wellington; Bart Staels; Michael R Hayden
Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.
The Journal of biological chemistry 2001;276(36):33969-79.
2001: Blair R Leavitt; Julian A Guttman; JG Hodgson; Gil Kimel; Roshni R Singaraja; A Wayne Vogl; Michael R Hayden
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
American journal of human genetics 2001;68(2):313-24.
2000: Abigail S Hackam; A S Yassa; Roshni R Singaraja; Martina Metzler; Claire-Anne Gutekunst; Lu Gan; Simon Warby; Cheryl L Wellington; John P Vaillancourt; Nansheng Chen; François G Gervais; L Raymond; Donald W Nicholson; Michael R Hayden
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
The Journal of biological chemistry 2000;275(52):41299-308.
2000: Vikramjit Chopra; Martina Metzler; Dita M Rasper; Asa E Y Engqvist-Goldstein; Roshni R Singaraja; Lu Gan; Keith Fichter; Krista McCutcheon; David G Drubin; Donald W Nicholson; Michael R Hayden
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):1006-15.
2000: Cheryl L Wellington; Roshni R Singaraja; Lisa M Ellerby; J Savill; Sophie Roy; Blair R Leavitt; Elena Cattaneo; Abigail S Hackam; A Sharp; N Thornberry; Donald W Nicholson; Dale E Bredesen; Michael R Hayden
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
The Journal of biological chemistry 2000;275(26):19831-8.
1999: Abigail S Hackam; JG Hodgson; Roshni R Singaraja; T Zhang; Lu Gan; Claire-Anne Gutekunst; Steven M Hersch; Michael R Hayden
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1047-55.
1999: JG Hodgson; N Agopyan; Claire-Anne Gutekunst; Blair R Leavitt; F LePiane; Roshni R Singaraja; Desmond J Smith; Nagat Bissada; Krista McCutcheon; Jamal Nasir; Laure Jamot; Xiao-Jiang Li; M E Stevens; E Rosemond; John C Roder; A G Phillips; E M Rubin; Steven M Hersch; Michael R Hayden
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Neuron 1999;23(1):181-92.
1999: Abigail S Hackam; Roshni R Singaraja; T Zhang; Lu Gan; Michael R Hayden
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
Human molecular genetics 1999;8(1):25-33.
1998: Abigail S Hackam; Roshni R Singaraja; Cheryl L Wellington; Martina Metzler; Krista McCutcheon; T Zhang; M Kalchman; Michael R Hayden
The influence of huntingtin protein size on nuclear localization and cellular toxicity.
The Journal of cell biology 1998;141(5):1097-105.
1998: Cheryl L Wellington; Lisa M Ellerby; Abigail S Hackam; Russell L Margolis; Mark Trifiro; Roshni R Singaraja; Krista McCutcheon; Guy S Salvesen; Stephanie Propp; M Bromm; K J Rowland; T Zhang; Dita M Rasper; Sophie Roy; N Thornberry; Leonard Pinsky; A Kakizuka; Christopher A Ross; Donald W Nicholson; Dale E Bredesen; Michael R Hayden
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Duane W Martindale; Abigail S Hackam; A Wieczorek; Lisa M Ellerby; Cheryl L Wellington; Krista McCutcheon; Roshni R Singaraja; P Kazemi-Esfarjani; Rebecca S Devon; Seung Kim; Dale E Bredesen; F Tufaro; Michael R Hayden
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.
Nature genetics 1998;18(2):150-4.