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Alfred Singer

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Motoko Y Kimura; Jung-Hyun Park; Leonid A Pobezinsky; Anthony Adams; Terry I Guinter; Xuguang Tai; Julien Thomas; Alfred Singer
IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.
Tom M McCaughtry; Jung-Hyun Park; Xuguang Tai; Amala Alag; Batu Erman; Ruth Etzensperger; Lionel Feigenbaum; Alex Grinberg; Sema Kurtulus; Paul Love; Alfred Singer
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
François Van Laethem; Anastasia N Tikhonova; Alfred Singer
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.

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2013: Motoko Y Kimura; Jung-Hyun Park; Leonid A Pobezinsky; Anthony Adams; Terry I Guinter; Xuguang Tai; Julien Thomas; Alfred Singer
IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.
Nature immunology 2013;14(2):143-51.
2012: Tom M McCaughtry; Jung-Hyun Park; Xuguang Tai; Amala Alag; Batu Erman; Ruth Etzensperger; Lionel Feigenbaum; Alex Grinberg; Sema Kurtulus; Paul Love; Alfred Singer
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
The Journal of experimental medicine 2012;209(12):2263-76.
2012: François Van Laethem; Anastasia N Tikhonova; Alfred Singer
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.
Trends in immunology 2012;33(9):437-41.
2012: Leonid A Pobezinsky; Xuguang Tai; François Van Laethem; Georgi S Angelov; Lionel Feigenbaum; Susanna Jeurling; Jung-Hyun Park; Alfred Singer
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Nature immunology 2012;13(6):569-78.
2012: Xuguang Tai; Craig B Thompson; François Van Laethem; Anthony Adams; Lionel Feigenbaum; Larry Granger; Terry I Guinter; Michael J Kruhlak; Tullia Lindsten; Leonid Pobezinsky; Susan O Sharrow; Alfred Singer
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood 2012;119(22):5155-63.
2012: Stanley Adoro; Jung-Hyun Park; Alfred Singer
Coreceptor gene "imprinting:" a genetic solution to a developmental dilemma in T cells.
Cell cycle (Georgetown, Tex.) 2012;11(5):833-4.
2012: Anastasia N Tikhonova; François Van Laethem; James C Yang; Peter D Sun; Günter Bernhardt; Terry I Guinter; Ken-ichi Hanada; Changwan Hong; Susanna K Jeurling; Jinghua Lu; Jung-Hyun Park; Leonid A Pobezinsky; Alfred Singer
αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity 2012;36(1):79-91.
2012: Stanley Adoro; Amala Alag; Rémy Bosselut; Batu Erman; Alex Grinberg; Motoko Kimura; Masato Kubo; Paul Love; Thomas McCaughtry; Jung-Hyun Park; Xuguang Tai; François Van Laethem; Lie Wang; Alfred Singer
Coreceptor gene imprinting governs thymocyte lineage fate.
The EMBO journal 2012;31(2):366-77.
2011: Joseph W Landry; Subhadra Banerjee; Barbara Taylor; Peter D Aplan; Alfred Singer; Carl Wu
Chromatin remodeling complex NURF regulates thymocyte maturation.
Genes & development 2011;25(3):275-86.
2010: Alfred Singer
Molecular and cellular basis of T cell lineage commitment: An overview.
Seminars in immunology 2010;22(5):253.
2010: Jung-Hyun Park; Stanley Adoro; Terry Guinter; Batu Erman; Amala S Alag; Marta Catalfamo; Motoko Y Kimura; Yongzhi Cui; Philip J Lucas; Ronald E Gress; Masato Kubo; Lothar Hennighausen; Lionel Feigenbaum; Alfred Singer
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Nature immunology 2010;11(3):257-64.
2009: Sophia D Sarafova; François Van Laethem; Stanley Adoro; Terry I Guinter; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Immunity 2009;31(3):480-90.
2008: Stanley Adoro; Batu Erman; Sophia D Sarafova; François Van Laethem; Jung-Hyun Park; Lionel Feigenbaum; Alfred Singer
Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6975-83.
2008: Alfred Singer; Stanley Adoro; Jung-Hyun Park
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.
Nature reviews. Immunology 2008;8(10):788-801.
2007: François Van Laethem; Sophia D Sarafova; Jung-Hyun Park; Xuguang Tai; Leonid Pobezinsky; Terry I Guinter; Stanley Adoro; Anthony Adams; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity 2007;27(5):735-50.
2007: Jung-Hyun Park; Stanley Adoro; Philip J Lucas; Sophia D Sarafova; Amala S Alag; loretta doan; Batu Erman; Xiaolong Liu; Wilfried Ellmeier; Rémy Bosselut; Lionel Feigenbaum; Alfred Singer
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Nature immunology 2007;8(10):1049-59.
2007: Xuguang Tai; François Van Laethem; Arlene H Sharpe; Alfred Singer
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13756-61.
2006: Batu Erman; Amala S Alag; Oyvind Dahle; François Van Laethem; Sophia D Sarafova; Terry I Guinter; Susan O Sharrow; Alexander Grinberg; Paul E Love; Alfred Singer
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6613-25.
2006: Daniel B Graham; Michael P Bell; Catherine J Huntoon; Matthew D Griffin; Xuguang Tai; Alfred Singer; David J McKean
CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6098-107.
2006: Qing Yu; Jung-Hyun Park; loretta doan; Batu Erman; Lionel Feigenbaum; Alfred Singer
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection.
The Journal of experimental medicine 2006;203(1):165-75.
2005: Sophia D Sarafova; Batu Erman; Qing Yu; François Van Laethem; Terry I Guinter; Susan O Sharrow; Lionel Feigenbaum; Kathryn F Wildt; Wilfried Ellmeier; Alfred Singer
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
Immunity 2005;23(1):75-87.
2005: Xuguang Tai; Michelle Cowan; Lionel Feigenbaum; Alfred Singer
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Nature immunology 2005;6(2):152-62.
2004: Qing Yu; Batu Erman; Jung-Hyun Park; Lionel Feigenbaum; Alfred Singer
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.
The Journal of experimental medicine 2004;200(6):797-803.
2004: Jung-Hyun Park; Qing Yu; Batu Erman; Jacob S Appelbaum; Diego Montoya-Durango; H Leighton Grimes; Alfred Singer
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.
Immunity 2004;21(2):289-302.
2004: Batu Erman; Terry I Guinter; Alfred Singer
Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation.
The Journal of experimental medicine 2004;199(12):1719-24.
2004: Alfred Singer; Rémy Bosselut
CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision.
Advances in immunology 2004;83():91-131.
2003: Rémy Bosselut; Terry I Guinter; Susan O Sharrow; Alfred Singer
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.
The Journal of experimental medicine 2003;197(12):1709-19.
2003: loretta doan; Mary Kate Kitay; Qing Yu; Alfred Singer; Sabine Herblot; Trang Hoang; Susan E Bear; Herbert C Morse; Philip Tsichlis; H Leighton Grimes
Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2356-66.
2003: Qing Yu; Batu Erman; Avinash Bhandoola; Susan O Sharrow; Alfred Singer
In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells.
The Journal of experimental medicine 2003;197(4):475-87.
2002: Avinash Bhandoola; Xuguang Tai; Michael Eckhaus; Hugh Auchincloss; Karen Mason; Steven A Rubin; Kathryn M Carbone; Zvi Grossman; Amy S Rosenberg; Alfred Singer
Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model.
Immunity 2002;17(4):425-36.
2002: Avinash Bhandoola; Rémy Bosselut; Qing Yu; Michelle L Cowan; Lionel Feigenbaum; Paul E Love; Alfred Singer
CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain.
European journal of immunology 2002;32(6):1811-7.
2002: Batu Erman; Lionel Feigenbaum; John E Coligan; Alfred Singer
Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development.
Nature immunology 2002;3(6):564-9.
2002: Alfred Singer
New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision.
Current opinion in immunology 2002;14(2):207-15.
2001: Rémy Bosselut; Lionel Feigenbaum; Susan O Sharrow; Alfred Singer
Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes.
Immunity 2001;14(4):483-94.
2001: David J McKean; Catherine J Huntoon; Michael P Bell; X Tai; Susan O Sharrow; KE Hedin; A Conley; Alfred Singer
Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3468-75.
2000: Avinash Bhandoola; B Dolnick; N Fayad; André Nussenzweig; Alfred Singer
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks.
The Journal of experimental medicine 2000;192(6):891-7.
2000: E Brugnera; Avinash Bhandoola; Ricardo Cibotti; Qing Yu; Terry I Guinter; Y Yamashita; Susan O Sharrow; Alfred Singer
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
Immunity 2000;13(1):59-71.
2000: Avinash Bhandoola; B Kithiganahalli; Larry Granger; Alfred Singer
Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus.
International immunology 2000;12(7):1035-40.
2000: Ricardo Cibotti; Avinash Bhandoola; Terry I Guinter; Susan O Sharrow; Alfred Singer
CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes.
Molecular and cellular biology 2000;20(11):3852-9.
2000: Rémy Bosselut; S Kubo; Terry I Guinter; J L Kopacz; John D Altman; Lionel Feigenbaum; Alfred Singer
Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.
Immunity 2000;12(4):409-18.
1999: Rémy Bosselut; W Zhang; JM Ashe; J L Kopacz; Lawrence E Samelson; Alfred Singer
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
The Journal of experimental medicine 1999;190(10):1517-26.
1999: Alfred Singer; Rémy Bosselut; Avinash Bhandoola
Signals involved in CD4/CD8 lineage commitment: current concepts and potential mechanisms.
Seminars in immunology 1999;11(4):273-81.
1999: JM Ashe; David L. Wiest; Ryo Abe; Alfred Singer
ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).
The Journal of experimental medicine 1999;189(7):1163-8.
1999: Avinash Bhandoola; Ricardo Cibotti; JA Punt; Larry Granger; A J Adams; Susan O Sharrow; Alfred Singer
Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment.
Immunity 1999;10(3):301-11.
1998: H Suzuki; Terry I Guinter; S Koyasu; Alfred Singer
Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus.
European journal of immunology 1998;28(10):3252-8.
1997: JA Punt; W Havran; Ryo Abe; A Sarin; Alfred Singer
T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus.
The Journal of experimental medicine 1997;186(11):1911-22.
1997: H Suzuki; Y Shinkai; Larry Granger; F W Alt; Paul E Love; Alfred Singer
Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains.
The Journal of experimental medicine 1997;186(1):17-23.
1997: David L. Wiest; JM Ashe; T Kevin Howcroft; H M Lee; D M Kemper; I Negishi; dinah singer; Alfred Singer; Ryo Abe
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Immunity 1997;6(6):663-71.
1997: David L. Wiest; Avinash Bhandoola; JA Punt; G Kreibich; D McKean; Alfred Singer
Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1884-9.
1997: Ricardo Cibotti; JA Punt; K S Dash; Susan O Sharrow; Alfred Singer
Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals.
Immunity 1997;6(3):245-55.
1996: JA Punt; H Suzuki; Larry Granger; Susan O Sharrow; Alfred Singer
Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.
The Journal of experimental medicine 1996;184(6):2091-9.
1996: David L. Wiest; J M Ashe; Ryo Abe; J B Bolen; Alfred Singer
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck.
Immunity 1996;4(5):495-504.
1995: Kelly P Kearse; J P Roberts; David L. Wiest; Alfred Singer
Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(12):1049-54.
1995: David L. Wiest; W H Burgess; D McKean; Kelly P Kearse; Alfred Singer
The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.
The EMBO journal 1995;14(14):3425-33.
1995: H Suzuki; JA Punt; Larry Granger; Alfred Singer
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.
Immunity 1995;2(4):413-25.
1995: Kelly P Kearse; J L Roberts; Alfred Singer
TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes.
Immunity 1995;2(4):391-9.
1995: Kelly P Kearse; Y Takahama; JA Punt; Susan O Sharrow; Alfred Singer
Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.
The Journal of experimental medicine 1995;181(1):193-202.
1994: Kelly P Kearse; J L Roberts; T I Munitz; David L. Wiest; T Nakayama; Alfred Singer
Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.
The EMBO journal 1994;13(19):4504-14.
1994: David L. Wiest; Kelly P Kearse; E W Shores; Alfred Singer
Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.
The Journal of experimental medicine 1994;180(4):1375-82.
1994: E W Shores; W Van Ewijk; Alfred Singer
Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes.
International immunology 1994;6(9):1393-402.
1994: Kelly P Kearse; D B Williams; Alfred Singer
Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum.
The EMBO journal 1994;13(16):3678-86.
1994: JA Punt; J L Roberts; Kelly P Kearse; Alfred Singer
Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains.
The Journal of experimental medicine 1994;180(2):587-93.
1994: P Benveniste; Y Takahama; David L. Wiest; T Nakayama; Susan O Sharrow; Alfred Singer
Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6933-7.
1994: Susan O Sharrow; L A Barden; Alfred Singer; Stephen I Katz
Quantitative differences in cell surface expression of class I MHC antigens on murine epidermal Langerhans cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):110-6.
1994: M G Lee; Susan O Sharrow; Andrew G Farr; Alfred Singer; Mark C Udey
Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5653-9.
1994: Y Takahama; John J Letterio; H Suzuki; Andrew G Farr; Alfred Singer
Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta.
The Journal of experimental medicine 1994;179(5):1495-506.
1994: Paul E Love; Elizabeth W Shores; E J Lee; Alexander Grinberg; T I Munitz; Heiner Westphal; Alfred Singer
Differential effects of zeta and eta transgenes on early alpha/beta T cell development.
The Journal of experimental medicine 1994;179(5):1485-94.
1994: JA Punt; B A Osborne; Y Takahama; Susan O Sharrow; Alfred Singer
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
The Journal of experimental medicine 1994;179(2):709-13.
1993: T Nakayama; David L. Wiest; KM Abraham; T I Munitz; Roger M Perlmutter; Alfred Singer
Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10534-8.
1993: David L. Wiest; L Yuan; J Jefferson; P Benveniste; M Tsokos; R D Klausner; L H Glimcher; Lawrence E Samelson; Alfred Singer
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
The Journal of experimental medicine 1993;178(5):1701-12.
1993: Paul E Love; Elizabeth W Shores; M D Johnson; Michel L Tremblay; E J Lee; Alexander Grinberg; S P Huang; Alfred Singer; Heiner Westphal
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Science (New York, N.Y.) 1993;261(5123):918-21.
1993: Kelly P Kearse; David L. Wiest; Alfred Singer
Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2438-42.
1993: E W Shores; T Nakayama; David L. Wiest; Y Takahama; Susan O Sharrow; Alfred Singer
Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1263-75.
1992: S J Anderson; KM Abraham; T Nakayama; Alfred Singer; Roger M Perlmutter
Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.
The EMBO journal 1992;11(13):4877-86.
1992: Y Takahama; Alfred Singer
Post-transcriptional regulation of early T cell development by T cell receptor signals.
Science (New York, N.Y.) 1992;258(5087):1456-62.
1992: Y Takahama; E W Shores; Alfred Singer
Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells.
Science (New York, N.Y.) 1992;258(5082):653-6.
1992: J L Roberts; Ryo Abe; E W Shores; Alfred Singer
Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1577-82.
1992: T Nakayama; Y Ueda; H Yamada; E W Shores; Alfred Singer; Carl H June
In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands.
Science (New York, N.Y.) 1992;257(5066):96-9.
1992: P H Stein; M A Rees; Alfred Singer
Reconstitution of (BALB/c x B6)F1 normal mice with stem cells and thymus from nonobese diabetic mice results in autoimmune insulitis of the normal hosts' pancreases.
Transplantation 1992;53(6):1347-52.
1992: P H Stein; Alfred Singer
Similar co-stimulation requirements of CD4+ and CD8+ primary T helper cells: role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation.
International immunology 1992;4(3):327-35.
1991: T Nakayama; Lawrence E Samelson; Y Nakayama; T I Munitz; M Sheard; Carl H June; Alfred Singer
Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):9949-53.
1991: Y Takahama; Susan O Sharrow; Alfred Singer
Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2883-91.
1991: E W Shores; W Van Ewijk; Alfred Singer
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment.
European journal of immunology 1991;21(7):1657-61.
1991: Amy S Rosenberg; T I Munitz; T G Maniero; Alfred Singer
Cellular basis of skin allograft rejection across a class I major histocompatibility barrier in mice depleted of CD8+ T cells in vivo.
The Journal of experimental medicine 1991;173(6):1463-71.
1991: E W Shores; Susan O Sharrow; Alfred Singer
Presence of CD4 and CD8 determinants on CD4-CD8- murine thymocytes: passive acquisition of CD8 accessory molecules.
European journal of immunology 1991;21(4):973-7.
1991: Y Takahama; A Kosugi; Alfred Singer
Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1134-41.
1990: J E Maguire; S A McCarthy; Alfred Singer; dinah singer
Inverse correlation between steady-state RNA and cell surface T cell receptor levels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(13):3131-4.
1990: T Nakayama; Carl H June; T I Munitz; M Sheard; S A McCarthy; Susan O Sharrow; Lawrence E Samelson; Alfred Singer
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4.
Science (New York, N.Y.) 1990;249(4976):1558-61.
1990: Amy S Rosenberg; DS Finbloom; T G Maniero; P H Van der Meide; Alfred Singer
Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4648-50.
1990: M A Rees; Amy S Rosenberg; Alfred Singer
T cell subsets mediating rejection of established fetal pancreas grafts and failure to observe graft adaptation.
Transplantation 1990;49(6):1130-3.
1990: M A Rees; Amy S Rosenberg; T I Munitz; Alfred Singer
In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2765-9.
1990: Juan Bonifacino; S A McCarthy; J E Maguire; T Nakayama; dinah singer; Richard D Klausner; Alfred Singer
Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4.
Nature 1990;344(6263):247-51.
1990: J L Roberts; Susan O Sharrow; Alfred Singer
Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
The Journal of experimental medicine 1990;171(3):935-40.
1990: E W Shores; Susan O Sharrow; I Uppenkamp; Alfred Singer
T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway.
European journal of immunology 1990;20(1):69-77.
1989: Jonathan P Schneck; T Munitz; John E Coligan; W L Maloy; David Margulies; Alfred Singer
Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8516-20.
1989: T Nakayama; Alfred Singer; E D Hsi; Lawrence E Samelson
Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain.
Nature 1989;341(6243):651-4.
1989: Amy S Rosenberg; Stephen I Katz; Alfred Singer
Rejection of skin allografts by CD4+ T cells is antigen-specific and requires expression of target alloantigen on Ia- epidermal cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2452-6.
1989: S A McCarthy; E Kaldjian; Alfred Singer
Characterization of anti-CD8-resistant cytolytic T lymphocytes induced by multivalent cross-linking of CD8 on precursor cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2112-9.
1989: J A Cole; S A McCarthy; M A Rees; Susan O Sharrow; Alfred Singer
Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):397-402.
1989: J C Zuñiga-Pflücker; S A McCarthy; M Weston; Dan Longo; Alfred Singer; A M Kruisbeek
Role of CD4 in thymocyte selection and maturation.
The Journal of experimental medicine 1989;169(6):2085-96.
1989: Amy S Rosenberg; B Weatherly; P Rose; Alfred Singer
Antigen specific effector mechanisms in skin allograft rejection.
Transplantation proceedings 1989;21(1 Pt 1):131-2.
1989: T I Munitz; Jonathan P Schneck; John E Coligan; W L Maloy; J P Henrich; Susan O Sharrow; David Margulies; Alfred Singer
A peptide derived from the alpha-helical region of class I MHC blocks CTL engagement of the class I MHC molecule.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():557-61.
1989: T Mizuochi; A W Hügin; Herbert C Morse; Alfred Singer; R M Buller
Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):270-3.
1989: S A McCarthy; Alfred Singer
T-lymphocyte associative recognition.
Immunology series 1989;43():399-442.
1988: S A McCarthy; E Kaldjian; Alfred Singer
Induction of anti-CD8 resistant cytotoxic T lymphocytes by anti-CD8 antibodies. Functional evidence for T cell signaling induced by multi-valent cross-linking of CD8 on precursor cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3737-46.
1988: S A McCarthy; A M Kruisbeek; I K Uppenkamp; Susan O Sharrow; Alfred Singer
Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
Nature 1988;336(6194):76-9.
1988: Amy S Rosenberg; Alfred Singer
Evidence that the effector mechanism of skin allograft rejection is antigen-specific.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7739-42.
1988: E Kaldjian; S A McCarthy; Susan O Sharrow; Dan R Littman; Richard D Klausner; Alfred Singer
Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(12):2801-6.
1988: T Mizuochi; L Tentori; Susan O Sharrow; A M Kruisbeek; Alfred Singer
Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation.
The Journal of experimental medicine 1988;168(1):437-42.
1988: Amy S Rosenberg; T Mizuochi; Alfred Singer
Evidence for involvement of dual-function T cells in rejection of MHC class I disparate skin grafts. Assessment of MHC class I alloantigens as in vivo helper determinants.
The Journal of experimental medicine 1988;168(1):33-45.
1988: Alfred Singer
Experimentation and thymic selection.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2481-3.
1988: J McCluskey; T Munitz; L Boyd; Ronald N Germain; John E Coligan; Alfred Singer; David Margulies
Cell surface expression of the amino-terminal domain of A kappa alpha. Recognition of an isolated MHC antigenic structure by allospecific T cells but not alloantibodies.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):2081-9.
1988: T Mizuochi; Alfred Singer
Intrathymic differentiation and tolerance induction of lymphokine-secreting Lyt-2+ T helper cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1421-4.
1988: Amy S Rosenberg; T Mizuochi; Alfred Singer
Cellular interactions resulting in skin-allograft rejection.
Annals of the New York Academy of Sciences 1988;532():76-85.
1988: Alfred Singer; Amy S Rosenberg
Immune mechanisms of tissue destruction in vivo.
Princess Takamatsu symposia 1988;19():209-14.
1987: Alfred Singer; T I Munitz; Ronald E Gress
Specificity of thymic selection and the role of self antigens.
Transplantation proceedings 1987;19(6 Suppl 7):107-10.
1987: Alfred Singer; T I Munitz; Hana Golding; Amy S Rosenberg; T Mizuochi
Recognition requirements for the activation, differentiation and function of T-helper cells specific for class I MHC alloantigens.
Immunological reviews 1987;98():143-70.
1986: T Mizuochi; T I Munitz; S A McCarthy; P M Andrysiak; J Kung; Ronald E Gress; Alfred Singer
Differential helper and effector responses of Lyt-2+ T cells to H-2Kb mutant (Kbm) determinants and the appearance of thymic influence on anti-Kbm CTL responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(9):2740-7.
1985: Hana Golding; J McCluskey; T I Munitz; Ronald N Germain; David Margulies; Alfred Singer
T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4.
Nature 1985;317(6036):425-7.
1985: Hana Golding; T I Munitz; Alfred Singer
Characterization of antigen-specific, Ia-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity.
The Journal of experimental medicine 1985;162(3):943-61.