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Dhirendra Singh

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Bhavana Chhunchha; Nigar Fatma; Eri Kubo; Prerana Rai; Sanjay P Singh; Dhirendra P Singh
Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.
Biju Bhargavan; Bhavana Chhunchha; Nigar Fatma; Eri Kubo; Anil Kumar; Dhirendra P Singh
Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.
Eri Kubo; Hiroshi Sasaki; Nigar Fatma; Nailia Hasanova; Dhirendra P Singh
Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells.

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All Publications

2013: Bhavana Chhunchha; Nigar Fatma; Eri Kubo; Prerana Rai; Sanjay P Singh; Dhirendra P Singh
Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.
American journal of physiology. Cell physiology 2013;304(7):C636-55.
2013: Biju Bhargavan; Bhavana Chhunchha; Nigar Fatma; Eri Kubo; Anil Kumar; Dhirendra P Singh
Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.
Epigenetics : official journal of the DNA Methylation Society 2013;8(3):268-80.
2013: Eri Kubo; Hiroshi Sasaki; Nigar Fatma; Nailia Hasanova; Dhirendra P Singh
Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells.
Journal of cellular and molecular medicine 2013;17(1):212-21.
2012: Keiichi Ishihara; Eri Kubo; Anil Kumar; Biju Bhargavan; Bhavana Chhunchha; Sanjib Dey; Nigar Fatma; Yoshihiro Takamura; Dhirendra P Singh
Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.
The FEBS journal 2012;279(17):3048-70.
2012: Ankit Shah; Peter S Silverstein; Dhirendra P Singh; Santosh Kumar; Anil Kumar
Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.
PloS one 2012;7(12):e52060.
2012: B Bhargavan; B Chhunchha; Nigar Fatma; Eri Kubo; V Singh; Dhirendra P Singh
LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.
Cell death & disease 2012;3():e316.
2012: Dhirendra P Singh; Biju Bhargavan; Bhavana Chhunchha; Eri Kubo; Anil Kumar; Nigar Fatma
Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter.
PloS one 2012;7(5):e37012.
2012: Ankit Shah; Peter S Silverstein; Dhirendra P Singh; Anil Kumar
Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes.
Journal of neuroinflammation 2012;9():52.
2011: Ankit Shah; Dhirendra P Singh; Shilpa Buch; Anil Kumar
HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway.
Biochemical and biophysical research communications 2011;414(1):112-7.
2011: Nigar Fatma; Eri Kubo; Toshimichi Shinohara; Biju Bhargavan; Bhavana Chhunchha; Prerna Singh; Dhirendra P Singh
Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.
American journal of physiology. Cell physiology 2011;301(4):C954-67.
2011: B Chhunchha; Nigar Fatma; Eri Kubo; A Kumar; B Bhargavan; Dhirendra P Singh
Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.
Cell death & disease 2011;2():e234.
2011: Rinku Baid; Robert I Scheinman; Toshimichi Shinohara; Dhirendra P Singh; Uday B Kompella
LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells.
PloS one 2011;6(9):e24616.
2011: Ankit Shah; Peter S Silverstein; Dhirendra P Singh; Leonidas Stamatatos; Ashish S Verma; Hari K Bhat; Shilpa Buch; Suman Chaudhary; Richard Noel; Kalpeshkumar H Patel; Vanessa Rivera-Amill; Anil Kumar
HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA.
PloS one 2011;6(6):e21261.
2010: Eri Kubo; Nailia Hasanova; Yukie Tanaka; Nigar Fatma; Yoshihiro Takamura; Dhirendra P Singh; Yoshio Akagi
Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure.
American journal of physiology. Cell physiology 2010;298(2):C342-54.
2010: Rajkumar Tulsawani; Lorena S Kelly; Nigar Fatma; Bhavanaben Chhunchha; Eri Kubo; Anil Kumar; Dhirendra P Singh
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage.
BMC neuroscience 2010;11():125.
2010: Norbert Babai; Nataly Kanevsky; Nathan Dascal; George J Rozanski; Dhirendra P Singh; Nigar Fatma; Wallace B Thoreson
Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells.
PloS one 2010;5(1):e8602.
2009: Nigar Fatma; Eri Kubo; Carol B Toris; W D Stamer; Carl B Camras; Dhirendra P Singh
PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
Free radical research 2009;43(9):783-95.
2009: Nigar Fatma; Eri Kubo; Yoshihiro Takamura; Keiichi Ishihara; Claudia Garcia; David C Beebe; Dhirendra P Singh
Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling.
The Journal of biological chemistry 2009;284(34):22758-72.
2009: Eri Kubo; Dhirendra P Singh; Nigar Fatma; Yoshio Akagi
TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes.
Life sciences 2009;84(23-24):857-64.
2008: Nigar Fatma; E Kubo; M Sen; N Agarwal; Wallace B Thoreson; C B Camras; Dhirendra P Singh
Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasis.
Brain research 2008;1233():63-78.
2008: Eri Kubo; Nigar Fatma; Yoshio Akagi; David Beier; Sanjay P Singh; Dhirendra P Singh
TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity.
American journal of physiology. Cell physiology 2008;294(3):C842-55.
2008: Dhirendra P Singh; Raghavan Govindarajan; A K S Rawat
High-performance liquid chromatography as a tool for the chemical standardisation of Triphala--an Ayurvedic formulation.
Phytochemical analysis : PCA 2008;19(2):164-8.
2007: Dhirendra P Singh; Raghavan Govindarajan; Anakshi Khare; A K S Rawat
Optimization of a high-performance liquid chromatography method for the separation and identification of six different classes of phenolics.
Journal of chromatographic science 2007;45(10):701-5.
2007: Raghavan Govindarajan; Dhirendra P Singh; A K S Rawat
High-performance liquid chromatographic method for the quantification of phenolics in 'Chyavanprash' a potent Ayurvedic drug.
Journal of pharmaceutical and biomedical analysis 2007;43(2):527-32.
2006: Jian L Pang; Dennis A Ricupero; Su Huang; Nigar Fatma; Dhirendra P Singh; Jose R Romero; Naibedya Chattopadhyay
Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells.
Biochemical pharmacology 2006;71(6):818-26.
2006: Eri Kubo; Tomoe Miyazawa; Nigar Fatma; Yoshio Akagi; Dhirendra P Singh
Development- and age-associated expression pattern of peroxiredoxin 6, and its regulation in murine ocular lens.
Mechanisms of ageing and development 2006;127(3):249-56.
2006: Yoshihiro Takamura; Nigar Fatma; Eri Kubo; Dhirendra P Singh
Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75.
American journal of physiology. Cell physiology 2006;290(2):C554-66.
2006: Dhirendra P Singh; Eri Kubo; Yoshihiro Takamura; Toshimichi Shinohara; A Kumar; Leo T Chylack; Nigar Fatma
DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF.
Journal of molecular biology 2006;355(3):379-94.
2005: Nigar Fatma; Eri Kubo; preeti sharma; David Beier; Dhirendra P Singh
Impaired homeostasis and phenotypic abnormalities in Prdx6-/-mice lens epithelial cells by reactive oxygen species: increased expression and activation of TGFbeta.
Cell death and differentiation 2005;12(7):734-50.
2005: Grissell Tirado; Gloria Jove; Evelyn Reyes; Gladys Sepulveda; Yasuhiro Yamamura; Dhirendra P Singh; Anil Kumar
Differential evolution of cell-associated virus in blood and genital tract of HIV-infected females undergoing HAART.
Virology 2005;334(2):299-305.
2004: Nigar Fatma; Eri Kubo; Leo T Chylack; Toshimichi Shinohara; Yoshio Akagi; Dhirendra P Singh
LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.
American journal of physiology. Cell physiology 2004;287(2):C508-16.
2004: Eri Kubo; T Urakami; Nigar Fatma; Yoshio Akagi; Dhirendra P Singh
Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2.
Biochemical and biophysical research communications 2004;314(4):1050-6.
2003: Yukihiro Inomata; Akira Hirata; Takahisa Koga; Akira Kimura; Dhirendra P Singh; Toshimichi Shinohara; Hidenobu Tanihara
Lens epithelium-derived growth factor: neuroprotection on rat retinal damage induced by N-methyl-D-aspartate.
Brain research 2003;991(1-2):163-70.
2003: preeti sharma; Nigar Fatma; Eri Kubo; Toshimichi Shinohara; Leo T Chylack; Dhirendra P Singh
Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells.
The Journal of biological chemistry 2003;278(22):20037-46.
2003: Eri Kubo; Dhirendra P Singh; Nigar Fatma; Toshimichi Shinohara; Peggy Zelenka; Venkat N Reddy; Leo T Chylack
Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells.
Histochemistry and cell biology 2003;119(4):289-99.
2002: Masahiko Ayaki; Nobuyuki Ohoguro; Noriyuki Azuma; Yoshinao Majima; Kiyomi Yata; Nobuhiro Ibaraki; Dhirendra P Singh; Vincent Ko; Toshimichi Shinohara
Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis.
Autoimmunity 2002;35(5):319-27.
2002: Eri Kubo; Nigar Fatma; preeti sharma; Toshimichi Shinohara; Leo T Chylack; Y Akagi; Dhirendra P Singh
Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF).
Journal of molecular biology 2002;320(5):1053-63.
2002: Toshimichi Shinohara; Dhirendra P Singh; Nigar Fatma
LEDGF, a survival factor, activates stress-related genes.
Progress in retinal and eye research 2002;21(3):341-58.
2001: Nigar Fatma; Dhirendra P Singh; Toshimichi Shinohara; Leo T Chylack
Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress.
The Journal of biological chemistry 2001;276(52):48899-907.
2001: H Matsui; Li-Ren Lin; Dhirendra P Singh; T Shinohara; Venkat N Reddy
Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress.
Investigative ophthalmology & visual science 2001;42(12):2935-41.
2001: Dhirendra P Singh; Nigar Fatma; A Kimura; Leo T Chylack; Toshimichi Shinohara
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes.
Biochemical and biophysical research communications 2001;283(4):943-55.
2001: S Machida; P Chaudhry; T Shinohara; Dhirendra P Singh; Venkat N Reddy; Leo T Chylack; Paul Sieving; Ronald A Bush
Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats.
Investigative ophthalmology & visual science 2001;42(5):1087-95.
2000: preeti sharma; Dhirendra P Singh; Nigar Fatma; Leo T Chylack; Toshimichi Shinohara
Activation of LEDGF gene by thermal-and oxidative-stresses.
Biochemical and biophysical research communications 2000;276(3):1320-4.
2000: Nigar Fatma; Dhirendra P Singh; Toshimichi Shinohara; Leo T Chylack
Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus.
Investigative ophthalmology & visual science 2000;41(9):2648-57.
2000: Toshimichi Shinohara; Dhirendra P Singh; Leo T Chylack
Review: Age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF).
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2000;16(2):181-91.
2000: M Nakamura; Dhirendra P Singh; Eri Kubo; Leo T Chylack; Toshimichi Shinohara
LEDGF: survival of embryonic chick retinal photoreceptor cells.
Investigative ophthalmology & visual science 2000;41(5):1168-75.
2000: Dhirendra P Singh; N Ohguro; T Kikuchi; T Sueno; Venkat N Reddy; K Yuge; Leo T Chylack; Toshimichi Shinohara
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts.
Biochemical and biophysical research communications 2000;267(1):373-81.
1999: Masahiko Ayaki; T Sueno; Dhirendra P Singh; Leo T Chylack; Toshimichi Shinohara
Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture.
Experimental eye research 1999;69(1):139-42.
1999: Dhirendra P Singh; N Ohguro; Leo T Chylack; Toshimichi Shinohara
Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses.
Investigative ophthalmology & visual science 1999;40(7):1444-51.
1999: Dhirendra P Singh; T Sueno; T Kikuchi; S C Guru; S Yu; J Horwitz; Leo T Chylack; Toshimichi Shinohara
Antibodies to a microbial peptide sharing sequence homology with betaA3-crystallin damage lens epithelial cells in vitro and in vivo.
Autoimmunity 1999;29(4):311-22.
1997: T Sueno; E Inoue; Dhirendra P Singh; T Awata; Leo T Chylack; Toshimichi Shinohara
Oral administration of lens homogenate suppresses antibody production in mice injected with beta-crystallin emulsified in CFA.
Experimental eye research 1997;64(3):379-85.
1997: Nobuhiro Ibaraki; Li-Ren Lin; Loan Dang; Venkat N Reddy; Dhirendra P Singh; T Sueno; Leo T Chylack; Toshimichi Shinohara
Anti-beta-crystallin antibodies (mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture.
Experimental eye research 1997;64(2):229-38.
1995: Dhirendra P Singh; S C Guru; T Kikuchi; T Abe; Toshimichi Shinohara
Autoantibodies against beta-crystallins induce lens epithelial cell damage and cataract formation in mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):993-9.