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Mahendra Pratap Singh

Research Profile

Chemicals & Drugs

Living Beings

Mouse
Rats

Anatomy

Corpus Striatum

Disorders

Physiology

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Publications

TOP 3
Manindra Nath Tiwari; Sonal Agrawal; Satya Prakash Gupta; Anurag Jyoti; Om Prakash; Rishi Shanker; Anand Kumar Singh; Mahendra Pratap Singh
Cypermethrin alters the expression profile of mRNAs in the adult rat striatum: a putative mechanism of postnatal pre-exposure followed by adulthood re-exposure-enhanced neurodegeneration.
Sharawan Yadav; Garima Srivastava; Pramod Kumar Srivastava; Sonal Agrawal; Anubhuti Dixit; Om Prakash; Ashish Singh; Anand Kumar Singh; Mahendra Pratap Singh
Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.
Garima Srivastava; Sharawan Yadav; Anubhuti Dixit; Devendra Kumar Patel; Om Prakash; Mahendra Pratap Singh
Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.

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All Publications

2012: Manindra Nath Tiwari; Sonal Agrawal; Satya Prakash Gupta; Anurag Jyoti; Om Prakash; Rishi Shanker; Anand Kumar Singh; Mahendra Pratap Singh
Cypermethrin alters the expression profile of mRNAs in the adult rat striatum: a putative mechanism of postnatal pre-exposure followed by adulthood re-exposure-enhanced neurodegeneration.
Neurotoxicity research 2012;22(4):321-34.
2012: Sharawan Yadav; Garima Srivastava; Pramod Kumar Srivastava; Sonal Agrawal; Anubhuti Dixit; Om Prakash; Ashish Singh; Anand Kumar Singh; Mahendra Pratap Singh
Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.
Molecular neurobiology 2012;46(2):495-512.
2012: Garima Srivastava; Sharawan Yadav; Anubhuti Dixit; Devendra Kumar Patel; Om Prakash; Mahendra Pratap Singh
Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
Free radical biology & medicine 2012;52(8):1294-306.
2012: Sharawan Yadav; Satya Prakash Gupta; Garima Srivastava; Pramod Kumar Srivastava; Mahendra Pratap Singh
Role of secondary mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Neurochemical research 2012;37(4):875-84.
2012: Anand Kumar Singh; Om Prakash; Manindra Nath Tiwari; Mahendra Pratap Singh
A current review of cypermethrin-induced neurotoxicity and nigrostriatal dopaminergic neurodegeneration.
Current neuropharmacology 2012;10(1):64-71.
2012: Naveen Kumar Singhal; Garima Srivastava; Sonal Agrawal; Swatantra Kumar Jain; Mahendra Pratap Singh
Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation?
Molecular neurobiology 2012;45(1):186-99.
2012: Anand Kumar Singh; Dhirendra Singh; Devendra Kumar Patel; Om Prakash; Manindra Nath Tiwari; Ghanshyam Upadhyay; Mahendra Pratap Singh
Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood.
Neurobiology of aging 2012;33(2):404-15.
2011: Garima Srivastava; Anubhuti Dixit; Om Prakash; Mahendra Pratap Singh
Tiny non-coding RNAs in Parkinson's disease: implications, expectations and hypes.
Neurochemistry international 2011;59(6):759-69.
2011: Anand Kumar Singh; Dhirendra Singh; Anubhuti Dixit; Devendra Kumar Patel; Om Prakash; Manindra Nath Tiwari; Ghanshyam Upadhyay; Mahendra Pratap Singh
Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):526-38.
2011: Virendra Singh; Ghanshyam Upadhyay; Neeraj Rastogi; Kalpana Singh; Mahendra Pratap Singh
Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women.
Genetic testing and molecular biomarkers 2011;15(5):343-9.
2011: Naveen Kumar Singhal; Garima Srivastava; Devendra Kumar Patel; Swatantra Kumar Jain; Mahendra Pratap Singh
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Journal of pineal research 2011;50(2):97-109.
2010: Manindra Nath Tiwari; Anand Kumar Singh; Israr Ahmad; Ghanshyam Upadhyay; Dhirendra Singh; Devendra Kumar Patel; Chetna Singh; Om Prakash; Mahendra Pratap Singh
Effects of cypermethrin on monoamine transporters, xenobiotic metabolizing enzymes and lipid peroxidation in the rat nigrostriatal system.
Free radical research 2010;44(12):1416-24.
2010: Mahendra Pratap Singh; V K Singh; D K Patel; P K Tandon; J S Gaur; Jai Raj Behari; Sudesh Yadav
Face mask application as a tool to diminish the particulate matter mediated heavy metal exposure among citizens of Lucknow, India.
The Science of the total environment 2010;408(23):5723-8.
2010: Mohana Krishna Mudiam; Mahendra Pratap Singh; D Kar Chowdhuri; Ramesh Chandra Murthy
Quantitative evaluation of benzene, toluene, and xylene in the larvae of Drosophila melanogaster by solid-phase microextraction/gas chromatography/mass spectrometry for potential use in toxicological studies.
Journal of AOAC International 2010;93(5):1595-9.
2010: Seema Singh; Naveen Kumar Singhal; Garima Srivastava; Mahendra Pratap Singh
Omics in mechanistic and predictive toxicology.
Toxicology mechanisms and methods 2010;20(7):355-62.
2010: Satya Prakash Gupta; Suman Patel; Sharawan Yadav; Anand Kumar Singh; Seema Singh; Mahendra Pratap Singh
Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?
Neurochemical research 2010;35(8):1206-13.
2010: Ghanshyam Upadhyay; Manindra Nath Tiwari; Om Prakash; Anurag Jyoti; Rishi Shanker; Mahendra Pratap Singh
Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48(6):1660-70.
2010: Avinash Kumar; Anand K Singh; Abnish K Gautam; Deepak Chandra; Divya Singh; Bendangla Changkija; Mahendra Pratap Singh; Ritu Trivedi
Identification of kaempferol-regulated proteins in rat calvarial osteoblasts during mineralization by proteomics.
Proteomics 2010;10(9):1730-9.
2010: Kavita Singh; Seema Singh; Naveen Kumar Singhal; Amit Sharma; Devendra Parmar; Mahendra Pratap Singh
Nicotine- and caffeine-mediated changes in gene expression patterns of MPTP-lesioned mouse striatum: Implications in neuroprotection mechanism.
Chemico-biological interactions 2010;185(2):81-93.
2010: Mahendra Pratap Singh; K Ravi Ram; M Mishra; M Shrivastava; D K Saxena; D Kar Chowdhuri
Effects of co-exposure of benzene, toluene and xylene to Drosophila melanogaster: alteration in hsp70, hsp60, hsp83, hsp26, ROS generation and oxidative stress markers.
Chemosphere 2010;79(5):577-87.
2010: Ghanshyam Upadhyay; Satya Prakash Gupta; Om Prakash; Mahendra Pratap Singh
Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations.
Chemico-biological interactions 2010;183(3):333-40.
2010: Garima Srivastava; Kavita Singh; Manindra Nath Tiwari; Mahendra Pratap Singh
Proteomics in Parkinson's disease: current trends, translational snags and future possibilities.
Expert review of proteomics 2010;7(1):127-39.
2009: Anil Dangi; Satish Vedi; Jeetendra Kumar Nag; Sameer Paithankar; Mahendra Pratap Singh; Santosh Kumar Kar; Anuradha Dube; Shailja Misra-Bhattacharya
Tetracycline treatment targeting Wolbachia affects expression of an array of proteins in Brugia malayi parasite.
Proteomics 2009;9(17):4192-208.
2009: Seema Singh; Kavita Singh; Satya Prakash Gupta; Devendra Kumar Patel; Vinod Kumar Singh; Raj Kumar Singh; Mahendra Pratap Singh
Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum.
Brain research 2009;1283():115-26.
2009: Seema Singh; Kavita Singh; Devendra Kumar Patel; Chetna Singh; Chandishwar Nath; Vinod Kumar Singh; Raj Kumar Singh; Mahendra Pratap Singh
The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
Rejuvenation research 2009;12(3):185-97.
2009: Supriya Swarnkar; Ethika Tyagi; Rahul Agrawal; Mahendra Pratap Singh; Chandishwar Nath
A comparative study on oxidative stress induced by LPS and rotenone in homogenates of rat brain regions.
Environmental toxicology and pharmacology 2009;27(2):219-24.
2009: Mahendra Pratap Singh; Mohana Krishna Mudiam; Neeraj Mathur; Daya Krishna Saxena; D Kar Chowdhuri
Induction of hsp70, hsp60, hsp83 and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation.
Toxicology and applied pharmacology 2009;235(2):226-43.
2009: Ashima Sinha; Nalini Srivastava; Seema Singh; Anand Kumar Singh; Shashi Bhushan; Rakesh Shukla; Mahendra Pratap Singh
Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach.
Clinica chimica acta; international journal of clinical chemistry 2009;400(1-2):14-20.
2009: Sharawan Yadav; Naveen Kumar Singhal; Virendra Singh; Neeraj Rastogi; Pramod Kumar Srivastava; Mahendra Pratap Singh
Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women.
Disease markers 2009;27(5):203-10.
2008: Ghanshyam Upadhyay; Anand Kumar Singh; Abhai Kumar; Om Prakash; Mahendra Pratap Singh
Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress.
European journal of pharmacology 2008;596(1-3):146-52.
2008: Virendra Singh; Devendra Parmar; Mahendra Pratap Singh
Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
Cancer investigation 2008;26(8):769-83.
2008: Suman Patel; Kavita Singh; Seema Singh; Mahendra Pratap Singh
Gene expression profiles of mouse striatum in control and maneb + paraquat-induced Parkinson's disease phenotype: validation of differentially expressed energy metabolizing transcripts.
Molecular biotechnology 2008;40(1):59-68.
2008: Seema Singh; Kavita Singh; Suman Patel; Devendra Kumar Patel; Chetna Singh; Chandishwar Nath; Mahendra Pratap Singh
Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse.
Brain research 2008;1207():193-206.
2008: Virendra Singh; Neeraj Rastogi; Neeraj Mathur; Kalpana Singh; Mahendra Pratap Singh
Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women.
Annals of epidemiology 2008;18(1):48-57.
2007: Abhai Kumar; Ghanshyam Upadhyay; Dinesh Raj Modi; Mahendra Pratap Singh
The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.
Life sciences 2007;81(23-24):1575-84.
2007: Suman Patel; Ashima Sinha; Mahendra Pratap Singh
Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse.
Neurotoxicology and teratology 2007;29(5):578-85.
2007: Ghanshyam Upadhyay; Abhai Kumar; Mahendra Pratap Singh
Effect of silymarin on pyrogallol- and rifampicin-induced hepatotoxicity in mouse.
European journal of pharmacology 2007;565(1-3):190-201.
2007: Ashima Sinha; Suman Patel; Mahendra Pratap Singh; Rakesh Shukla
Blood proteome profiling in case controls and Parkinson's disease patients in Indian population.
Clinica chimica acta; international journal of clinical chemistry 2007;380(1-2):232-4.
2007: Ashima Sinha; Chetna Singh; Devendra Parmar; Mahendra Pratap Singh
Proteomics in clinical interventions: achievements and limitations in biomarker development.
Life sciences 2007;80(15):1345-54.
2007: Virendra Singh; Neeraj Rastogi; Ashima Sinha; Abhai Kumar; Neeraj Mathur; Mahendra Pratap Singh
A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.
Breast cancer research and treatment 2007;101(1):73-81.
2006: Abhai Kumar; Suman Patel; Yogendra Kumar Gupta; Mahendra Pratap Singh
Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury.
Molecular and cellular biochemistry 2006;286(1-2):43-51.
2006: Suman Patel; Virendra Singh; Abhai Kumar; Yogendra Kumar Gupta; Mahendra Pratap Singh
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration.
Brain research 2006;1081(1):9-18.