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Andrew Singleton

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Clarimón J; Djaldetti R; Lleó A; Guerreiro R J; Molinuevo J L; Paisán-Ruiz C; Gómez-Isla T; Blesa R; Singleton A; Hardy J
Whole genome analysis in a consanguineous family with early onset Alzheimer's disease.
Ganesh Santhi K; Zakai Neil A; van Rooij Frank J A; Soranzo Nicole; Smith Albert V; Nalls Michael A; Chen Ming-Huei; Kottgen Anna; Glazer Nicole L; Dehghan Abbas; Kuhnel Brigitte; Aspelund Thor; Yang Qiong; Tanaka Toshiko; Jaffe Andrew; Bis Joshua C M; Verwoert Germaine C; Teumer Alexander; Fox Caroline S; Guralnik Jack M; Ehret Georg B; Rice Kenneth; Felix Janine F; Rendon Augusto; Eiriksdottir Gudny; Levy Daniel; Patel Kushang V; Boerwinkle Eric; Rotter Jerome I; Hofman Albert; Sambrook Jennifer G; Hernandez Dena G; Zheng Gang; Bandinelli Stefania; Singleton Andrew B; Coresh Josef; Lumley Thomas; Uitterlinden André G; Vangils Janine M; Launer Lenore J; Cupples L Adrienne; Oostra Ben A; Zwaginga Jaap-Jan; Ouwehand Willem H; Thein Swee-Lay; Meisinger Christa; Deloukas Panos; Nauck Matthias; Spector Tim D; Gieger Christian; Gudnason Vilmundur; van Duijn Cornelia M; Psaty Bruce M; Ferrucci Luigi; Chakravarti Aravinda; Greinacher Andreas; O'Donnell Christopher J; Witteman Jacqueline C M; Furth Susan; Cushman Mary; Harris Tamara B; Lin Jing-Ping
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
Matarin Mar; Brown W Mark; Dena Hernandez; Britton Angela; De Vrieze Fabienne Wavrant; Brott Thomas G; Brown Robert D; Worrall Bradford B; Case L Douglas; Chanock Stephen J; Metter E Jeffrey; Ferruci Luigi; Gamble Dale; Hardy John A; Rich Stephen S; Singleton Andrew; Meschia James F
Candidate gene polymorphisms for ischemic stroke.

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All Publications

2009: Clarimón J; Djaldetti R; Lleó A; Guerreiro R J; Molinuevo J L; Paisán-Ruiz C; Gómez-Isla T; Blesa R; Singleton A; Hardy J
Whole genome analysis in a consanguineous family with early onset Alzheimer's disease.
Neurobiology of aging 2009;30(12):1986-91.
2009: Ganesh Santhi K; Zakai Neil A; van Rooij Frank J A; Soranzo Nicole; Smith Albert V; Nalls Michael A; Chen Ming-Huei; Kottgen Anna; Glazer Nicole L; Dehghan Abbas; Kuhnel Brigitte; Aspelund Thor; Yang Qiong; Tanaka Toshiko; Jaffe Andrew; Bis Joshua C M; Verwoert Germaine C; Teumer Alexander; Fox Caroline S; Guralnik Jack M; Ehret Georg B; Rice Kenneth; Felix Janine F; Rendon Augusto; Eiriksdottir Gudny; Levy Daniel; Patel Kushang V; Boerwinkle Eric; Rotter Jerome I; Hofman Albert; Sambrook Jennifer G; Hernandez Dena G; Zheng Gang; Bandinelli Stefania; Singleton Andrew B; Coresh Josef; Lumley Thomas; Uitterlinden André G; Vangils Janine M; Launer Lenore J; Cupples L Adrienne; Oostra Ben A; Zwaginga Jaap-Jan; Ouwehand Willem H; Thein Swee-Lay; Meisinger Christa; Deloukas Panos; Nauck Matthias; Spector Tim D; Gieger Christian; Gudnason Vilmundur; van Duijn Cornelia M; Psaty Bruce M; Ferrucci Luigi; Chakravarti Aravinda; Greinacher Andreas; O'Donnell Christopher J; Witteman Jacqueline C M; Furth Susan; Cushman Mary; Harris Tamara B; Lin Jing-Ping
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
Nature genetics 2009;41(11):1191-8.
2009: Matarin Mar; Brown W Mark; Dena Hernandez; Britton Angela; De Vrieze Fabienne Wavrant; Brott Thomas G; Brown Robert D; Worrall Bradford B; Case L Douglas; Chanock Stephen J; Metter E Jeffrey; Ferruci Luigi; Gamble Dale; Hardy John A; Rich Stephen S; Singleton Andrew; Meschia James F
Candidate gene polymorphisms for ischemic stroke.
Stroke; a journal of cerebral circulation 2009;40(11):3436-42.
2009: Harold Denise; Abraham Richard; Hollingworth Paul; Sims Rebecca; Gerrish Amy; Hamshere Marian L; Pahwa Jaspreet Singh; Moskvina Valentina; Dowzell Kimberley; Williams Amy; Jones Nicola; Thomas Charlene; Stretton Alexandra; Morgan Angharad R; Lovestone Simon; Powell John; Proitsi Petroula; Lupton Michelle K; Brayne Carol; Rubinsztein David C; Gill Michael; Lawlor Brian; Lynch Aoibhinn; Morgan Kevin; Brown Kristelle S; Passmore Peter A; Craig David; McGuinness Bernadette; Todd Stephen; Holmes Clive; Mann David; Smith A David; Love Seth; Kehoe Patrick G; Hardy John; Mead Simon; Fox Nick; Rossor Martin; Collinge John; Maier Wolfgang; Jessen Frank; Schürmann Britta; van den Bussche Hendrik; Heuser Isabella; Kornhuber Johannes; Wiltfang Jens; Dichgans Martin; Frölich Lutz; Hampel Harald; Hüll Michael; Rujescu Dan; Goate Alison M; Kauwe John S K; Cruchaga Carlos; Nowotny Petra; Morris John C; Mayo Kevin; Sleegers Kristel; Bettens Karolien; Engelborghs Sebastiaan; De Deyn Peter P; Van Broeckhoven Christine; Livingston Gill; Bass Nicholas J; Gurling Hugh; McQuillin Andrew; Gwilliam Rhian; Deloukas Panagiotis; Al-Chalabi Ammar; Shaw Christopher E; Tsolaki Magda; Singleton Andrew B; Guerreiro Rita; Mühleisen Thomas W; Nöthen Markus M; Moebus Susanne; Jöckel Karl-Heinz; Klopp Norman; Wichmann H-Erich; Carrasquillo Minerva M; Pankratz V Shane; Younkin Steven G; Holmans Peter A; O'Donovan Michael; Owen Michael J; Williams Julie
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature genetics 2009;41(10):1088-93.
2009: Bras Jose; Paisan-Ruiz Coro; Guerreiro Rita; Ribeiro Maria Helena; Morgadinho Ana; Januario Cristina; Sidransky Ellen; Oliveira Catarina; Singleton Andrew
Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal.
Neurobiology of aging 2009;30(9):1515-7.
2009: Paisán-Ruiz Coro; Washecka Nicole; Nath Priti; Singleton Andrew B; Corder Elizabeth H
Parkinson's disease and low frequency alleles found together throughout LRRK2.
Annals of human genetics 2009;73(Pt 4):391-403.
2009: Murray Anna; Cluett Christie; Bandinelli Stefania; Corsi Anna Maria; Ferrucci Luigi; Guralnik Jack; Singleton Andrew; Frayling Timothy; Melzer David
Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
European heart journal 2009;30(14):1711-9.
2009: Neumann Juliane; Bras Jose; Deas Emma; O'Sullivan Sean S; Parkkinen Laura; Lachmann Robin H; Li Abi; Holton Janice; Guerreiro Rita; Paudel Reema; Segarane Badmavady; Singleton Andrew; Lees Andrew; Hardy John; Houlden Henry; Revesz Tamas; Wood Nicholas W
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.
Brain : a journal of neurology 2009;132(Pt 7):1783-94.
2009: Nalls M A; Guerreiro R J; Simon-Sanchez J; Bras J T; Traynor B J; Gibbs J R; Launer L; Hardy J; Singleton A B
Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.
Neurogenetics 2009;10(3):183-90.
2009: Bras Jose Miguel; Singleton Andrew
Genetic susceptibility in Parkinson's disease.
Biochimica et biophysica acta 2009;1792(7):597-603.
2009: Bucan Maja; Abrahams Brett S; Wang Kai; Glessner Joseph T; Herman Edward I; Sonnenblick Lisa I; Alvarez Retuerto Ana I; Imielinski Marcin; Hadley Dexter; Bradfield Jonathan P; Kim Cecilia; Gidaya Nicole B; Lindquist Ingrid; Hutman Ted; Sigman Marian; Kustanovich Vlad; Lajonchere Clara M; Singleton Andrew; Kim Junhyong; Wassink Thomas H; McMahon William M; Owley Thomas; Sweeney John A; Coon Hilary; Nurnberger John I; Li Mingyao; Cantor Rita M; Minshew Nancy J; Sutcliffe James S; Cook Edwin H; Dawson Geraldine; Buxbaum Joseph D; Grant Struan F A; Schellenberg Gerard D; Geschwind Daniel H; Hakonarson Hakon
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.
PLoS genetics 2009;5(6):e1000536.
2009: Brooks J; Ding J; Simon-Sanchez J; Paisan-Ruiz C; Singleton A B; Scholz S W
Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control.
Journal of medical genetics 2009;46(6):375-81.
2009: Scholz Sonja W; Houlden Henry; Schulte Claudia; Sharma Manu; Li Abi; Berg Daniela; Melchers Anna; Paudel Reema; Gibbs J Raphael; Simon-Sanchez Javier; Paisan-Ruiz Coro; Bras Jose; Ding Jinhui; Chen Honglei; Traynor Bryan J; Arepalli Sampath; Zonozi Ryan R; Revesz Tamas; Holton Janice; Wood Nick; Lees Andrew; Oertel Wolfgang; Wüllner Ullrich; Goldwurm Stefano; Pellecchia Maria Teresa; Illig Thomas; Riess Olaf; Fernandez Hubert H; Rodriguez Ramon L; Okun Michael S; Poewe Werner; Wenning Gregor K; Hardy John A; Singleton Andrew B; Gasser Thomas
SNCA variants are associated with increased risk for multiple system atrophy.
Annals of neurology 2009;65(5):610-4.
2009: Traynor Bryan J; Singleton Andrew B
What's the FUS!
Lancet neurology 2009;8(5):418-9.
2009: Hardy John; Singleton Andrew
Genomewide association studies and human disease.
The New England journal of medicine 2009;360(17):1759-68.
2009: Tanaka Toshiko; Scheet Paul; Giusti Betti; Bandinelli Stefania; Piras Maria Grazia; Usala Gianluca; Lai Sandra; Mulas Antonella; Corsi Anna Maria; Vestrini Anna; Sofi Francesco; Gori Anna Maria; Abbate Rosanna; Guralnik Jack; Singleton Andrew; Abecasis Goncalo R; Schlessinger David; Uda Manuela; Ferrucci Luigi
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
American journal of human genetics 2009;84(4):477-82.
2009: Camargos Sarah Teixeira; Dornas Leonardo Oliveira; Momeni Parastoo; Lees Andrew; Hardy John; Singleton Andrew; Cardoso Francisco
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Movement disorders : official journal of the Movement Disorder Society 2009;24(5):662-6.
2009: Chiò Adriano; Schymick Jennifer C; Restagno Gabriella; Scholz Sonja W; Lombardo Federica; Lai Shiao-Lin; Mora Gabriele; Fung Hon-Chung; Britton Angela; Arepalli Sampath; Gibbs J Raphael; Nalls Michael; Berger Stephen; Kwee Lydia Coulter; Oddone Eugene Z; Ding Jinhui; Crews Cynthia; Rafferty Ian; Washecka Nicole; Hernandez Dena; Ferrucci Luigi; Bandinelli Stefania; Guralnik Jack; Macciardi Fabio; Torri Federica; Lupoli Sara; Chanock Stephen J; Thomas Gilles; Hunter David J; Gieger Christian; Wichmann H Erich; Calvo Andrea; Mutani Roberto; Battistini Stefania; Giannini Fabio; Caponnetto Claudia; Mancardi Giovanni Luigi; La Bella Vincenzo; Valentino Francesca; Monsurrò Maria Rosaria; Tedeschi Gioacchino; Marinou Kalliopi; Sabatelli Mario; Conte Amelia; Mandrioli Jessica; Sola Patrizia; Salvi Fabrizio; Bartolomei Ilaria; Siciliano Gabriele; Carlesi Cecilia; Orrell Richard W; Talbot Kevin; Simmons Zachary; Connor James; Pioro Erik P; Dunkley Travis; Stephan Dietrich A; Kasperaviciute Dalia; Fisher Elizabeth M; Jabonka Sibylle; Sendtner Michael; Beck Marcus; Bruijn Lucie; Rothstein Jeffrey; Schmidt Silke; Singleton Andrew; Hardy John; Traynor Bryan J
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(8):1524-32.
2009: Nalls Michael A; Simon-Sanchez Javier; Gibbs J Raphael; Paisan-Ruiz Coro; Bras Jose Tomas; Tanaka Toshiko; Matarin Mar; Scholz Sonja; Weitz Charles; Harris Tamara B; Ferrucci Luigi; Hardy John; Singleton Andrew B
Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics.
PLoS genetics 2009;5(3):e1000415.
2009: Defazio Giovanni; Matarin Mar; Peckham Elizabeth L; Martino Davide; Valente Enza M; Singleton Andrew; Crawley Anthony; Aniello Maria Stella; Brancati Francesco; Abbruzzese Giovanni; Girlanda Paolo; Livrea Paolo; Hallett Mark; Berardelli Alfredo
The TOR1A polymorphism rs1182 and the risk of spread in primary blepharospasm.
Movement disorders : official journal of the Movement Disorder Society 2009;24(4):613-6.
2009: Huang Lucy; Li Yun; Singleton Andrew B; Hardy John A; Abecasis Gonçalo; Rosenberg Noah A; Scheet Paul
Genotype-imputation accuracy across worldwide human populations.
American journal of human genetics 2009;84(2):235-50.
2009: Ferrucci Luigi; Perry John R B; Matteini Amy; Perola Markus; Tanaka Toshiko; Silander Kaisa; Rice Neil; Melzer David; Murray Anna; Cluett Christie; Fried Linda P; Albanes Demetrius; Corsi Anna-Maria; Cherubini Antonio; Guralnik Jack; Bandinelli Stefania; Singleton Andrew; Virtamo Jarmo; Walston Jeremy; Semba Richard D; Frayling Timothy M
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
American journal of human genetics 2009;84(2):123-33.
2009: Bronstein Jeff; Carvey Paul; Chen Honglei; Cory-Slechta Deborah; DiMonte Donato; Duda John; English Paul; Goldman Samuel; Grate Stephen; Hansen Johnni; Hoppin Jane; Jewell Sarah; Kamel Freya; Koroshetz Walter; Langston James W; Logroscino Giancarlo; Nelson Lorene; Ravina Bernard; Rocca Walter; Ross George W; Schettler Ted; Schwarzschild Michael; Scott Bill; Seegal Richard; Singleton Andrew; Steenland Kyle; Tanner Caroline M; Van Den Eeden Stephen; Weisskopf Marc
Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007.
Environmental health perspectives 2009;117(1):117-21.
2009: Wickremaratchi Mindhu M; Majounie Elisa; Morris Huw R; Williams Nigel M; Lewis Helen; Gill Steven S; Khan Sadaquate; Heywood Peter; Hardy John; Wiles Charles M; Singleton Andrew B; Quinn Niall P
Parkin-related disease clinically diagnosed as a pallido-pyramidal syndrome.
Movement disorders : official journal of the Movement Disorder Society 2009;24(1):138-40.
2009: Bras Jose; Simón-Sánchez Javier; Federoff Monica; Morgadinho Ana; Januario Cristina; Ribeiro Maria; Cunha Luis; Oliveira Catarina; Singleton Andrew B
Lack of replication of association between GIGYF2 variants and Parkinson disease.
Human molecular genetics 2009;18(2):341-6.
2009: Paisan-Ruiz Coro; Bhatia Kailash P; Li Abi; Hernandez Dena; Davis Mary; Wood Nick W; Hardy John; Houlden Henry; Singleton Andrew; Schneider Susanne A
Characterization of PLA2G6 as a locus for dystonia-parkinsonism.
Annals of neurology 2009;65(1):19-23.
2008: Bras Jose; Singleton Andrew; Cookson Mark R; Hardy John
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.
The FEBS journal 2008;275(23):5767-73.
2008: Knight Melanie A; Hernandez Dena; Diede Scott J; Dauwerse Hans G; Rafferty Ian; van de Leemput Joyce; Forrest Susan M; Gardner R J McKinlay; Storey Elsdon; van Ommen Gert-Jan B; Tapscott Stephen J; Fischbeck Kenneth H; Singleton Andrew B
A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20.
Human molecular genetics 2008;17(24):3847-53.
2008: Simón-Sánchez Javier; Singleton Andrew
Genome-wide association studies in neurological disorders.
Lancet neurology 2008;7(11):1067-72.
2008: Ludlow Christy L; Adler Charles H; Berke Gerald S; Bielamowicz Steven A; Blitzer Andrew; Bressman Susan B; Hallett Mark; Jinnah H A; Juergens Uwe; Martin Sandra B; Perlmutter Joel S; Sapienza Christine; Singleton Andrew; Tanner Caroline M; Woodson Gayle E
Research priorities in spasmodic dysphonia.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2008;139(4):495-505.
2008: Paisan-Ruiz C; Nath P; Wood N W; Singleton A; Houlden H
Clinical heterogeneity and genotype-phenotype correlations in hereditary spastic paraplegia because of Spatacsin mutations (SPG11).
European journal of neurology : the official journal of the European Federation of Neurological Societies 2008;15(10):1065-70.
2008: Peuralinna Terhi; Oinas Minna; Polvikoski Tuomo; Paetau Anders; Sulkava Raimo; Niinistö Leena; Kalimo Hannu; Hernandez Dena; Hardy John; Singleton Andrew; Tienari Pentti J; Myllykangas Liisa
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.
Annals of neurology 2008;64(3):348-52.
2008: Bandmann O; Singleton A B
Yet another spinocerebellar ataxia: the saga continues.
Neurology 2008;71(8):542-3.
2008: Singleton Andrew; Morris Huw
Association, expression, pathobiology: is too much tau in PD a blueprint for genetic association?
Neurology 2008;71(1):11-2.
2008: Guerreiro Rita Joao; Santana Isabel; Bras Jose Miguel; Revesz Tamas; Rebelo Olinda; Ribeiro Maria Helena; Santiago Beatriz; Oliveira Catarina Resende; Singleton Andrew; Hardy John
Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases.
Movement disorders : official journal of the Movement Disorder Society 2008;23(9):1269-73.
2008: Pchelina S N; Yakimovskii A F; Emelyanov A K; Ivanova O N; Schwarzman A L; Singleton A B
Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2008;15(7):692-6.
2008: Simón-Sánchez Javier; Singleton Andrew B
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.
Human molecular genetics 2008;17(13):1988-93.
2008: Xiromerisiou Georgia; Hadjigeorgiou Georgios M; Papadimitriou Alexandros; Katsarogiannis Evaggelos; Gourbali Vasiliki; Singleton Andrew B
Association between AKT1 gene and Parkinson's disease: a protective haplotype.
Neuroscience letters 2008;436(2):232-4.
2008: Matarin Mar; Brown W Mark; Singleton Andrew; Hardy John A; Meschia James F;
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.
Stroke; a journal of cerebral circulation 2008;39(5):1586-9.
2008: Scholz Sonja; Singleton Andrew
Susceptibility genes in movement disorders.
Movement disorders : official journal of the Movement Disorder Society 2008;23(7):927-34; quiz 1064.
2008: Matarin Mar; Simon-Sanchez Javier; Fung Hon-Chung; Scholz Sonja; Gibbs J Raphael; Hernandez Dena G; Crews Cynthia; Britton Angela; De Vrieze Fabienne Wavrant; Brott Thomas G; Brown Robert D; Worrall Bradford B; Silliman Scott; Case L Douglas; Hardy John A; Rich Stephen S; Meschia James F; Singleton Andrew B
Structural genomic variation in ischemic stroke.
Neurogenetics 2008;9(2):101-8.
2008: Walsh Tom; McClellan Jon M; McCarthy Shane E; Addington Anjené M; Pierce Sarah B; Cooper Greg M; Nord Alex S; Kusenda Mary; Malhotra Dheeraj; Bhandari Abhishek; Stray Sunday M; Rippey Caitlin F; Roccanova Patricia; Makarov Vlad; Lakshmi B; Findling Robert L; Sikich Linmarie; Stromberg Thomas; Merriman Barry; Gogtay Nitin; Butler Philip; Eckstrand Kristen; Noory Laila; Gochman Peter; Long Robert; Chen Zugen; Davis Sean; Baker Carl; Eichler Evan E; Meltzer Paul S; Nelson Stanley F; Singleton Andrew B; Lee Ming K; Rapoport Judith L; King Mary-Claire; Sebat Jonathan
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
Science (New York, N.Y.) 2008;320(5875):539-43.
2008: Paisan-Ruiz C; Dogu O; Yilmaz A; Houlden H; Singleton A
SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia.
Neurology 2008;70(16 Pt 2):1384-9.
2008: Paisán-Ruíz Coro; Nath Priti; Washecka Nicole; Gibbs J Raphael; Singleton Andrew B
Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.
Human mutation 2008;29(4):485-90.
2008: Hardy John; Singleton Andrew
The HapMap: charting a course for genetic discovery in neurological diseases.
Archives of neurology 2008;65(3):319-21.
2008: Mochel Fanny; Knight Melanie A; Tong Wing-Hang; Hernandez Dena; Ayyad Karen; Taivassalo Tanja; Andersen Peter M; Singleton Andrew; Rouault Tracey A; Fischbeck Kenneth H; Haller Ronald G
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
American journal of human genetics 2008;82(3):652-60.
2008: Camargos Sarah; Scholz Sonja; Simón-Sánchez Javier; Paisán-Ruiz Coro; Lewis Patrick; Hernandez Dena; Ding Jinhui; Gibbs J Raphael; Cookson Mark R; Bras Jose; Guerreiro Rita; Oliveira Catarina Resende; Lees Andrew; Hardy John; Cardoso Francisco; Singleton Andrew B
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.
Lancet neurology 2008;7(3):207-15.
2008: Clarimón Jordi; Pagonabarraga Javier; Paisán-Ruíz Coro; Campolongo Antonia; Pascual-Sedano Berta; Martí-Massó José-Félix; Singleton Andrew B; Kulisevsky Jaime
Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.
Movement disorders : official journal of the Movement Disorder Society 2008;23(4):518-23.
2008: Hardy John; Low Nancy; Singleton Andrew
Whole genome association studies: deciding when persistence becomes perseveration.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(2):131-3.
2008: Jakobsson Mattias; Scholz Sonja W; Scheet Paul; Gibbs J Raphael; VanLiere Jenna M; Fung Hon-Chung; Szpiech Zachary A; Degnan James H; Wang Kai; Guerreiro Rita; Bras Jose M; Schymick Jennifer C; Hernandez Dena G; Traynor Bryan J; Simon-Sanchez Javier; Matarin Mar; Britton Angela; van de Leemput Joyce; Rafferty Ian; Bucan Maja; Cann Howard M; Hardy John A; Rosenberg Noah A; Singleton Andrew B
Genotype, haplotype and copy-number variation in worldwide human populations.
Nature 2008;451(7181):998-1003.
2008: Simon-Sanchez Javier; Scholz Sonja; Matarin Maria del Mar; Fung Hon-Chung; Hernandez Dena; Gibbs J Raphael; Britton Angela; Hardy John; Singleton Andrew
Genomewide SNP assay reveals mutations underlying Parkinson disease.
Human mutation 2008;29(2):315-22.
2008: Camargos Sarah Teixeira; Cardoso Francisco; Momeni Parastoo; Gianetti Juliana Gurgel; Lees Andrew; Hardy John; Singleton Andrew
Novel GCH1 mutation in a Brazilian family with dopa-responsive dystonia.
Movement disorders : official journal of the Movement Disorder Society 2008;23(2):299-302.
2008: Matarin Mar; Brown W Mark; Hardy John A; Rich Stephen S; Singleton Andrew B; Brown Robert D; Brott Thomas G; Worrall Bradford B; Meschia James F;
Association of integrin alpha2 gene variants with ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):81-9.
2008: Okubadejo Njideka; Britton Angela; Crews Cynthia; Akinyemi Rufus; Hardy John; Singleton Andrew; Bras Jose
Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
PloS one 2008;3(10):e3421.
2008: Guerreiro Rita J; Schymick Jennifer C; Crews Cynthia; Singleton Andrew; Hardy John; Traynor Bryan J
TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.
PloS one 2008;3(6):e2450.
2008: Tanskanen Maarit; Peuralinna Terhi; Polvikoski Tuomo; Notkola Irma-Leena; Sulkava Raimo; Hardy John; Singleton Andrew; Kiuru-Enari Sari; Paetau Anders; Tienari Pentti J; Myllykangas Liisa
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.
Annals of medicine 2008;40(3):232-9.
2008: Bras Jose; Guerreiro Rita; Ribeiro Maria; Morgadinho Ana; Januario Cristina; Dias Margarida; Calado Ana; Semedo Cristina; Oliveira Catarina; Hardy John; Singleton Andrew
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
BMC neurology 2008;8():1.
2007: Greggio Elisa; Singleton Andrew
Kinase signaling pathways as potential targets in the treatment of Parkinson's disease.
Expert review of proteomics 2007;4(6):783-92.
2007: Houlden Henry; Johnson Janel; Gardner-Thorpe Christopher; Lashley Tammaryn; Hernandez Dena; Worth Paul; Singleton Andrew B; Hilton David A; Holton Janice; Revesz Tamas; Davis Mary B; Giunti Paola; Wood Nicholas W
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.
Nature genetics 2007;39(12):1434-6.
2007: Traynor Bryan J; Singleton Andrew
Genome-wide association studies and ALS: are we there yet?
Lancet neurology 2007;6(10):841-3.
2007: Goldstein D S; Imrich R; Peckham E; Holmes C; Lopez G; Crews C; Hardy J; Singleton A; Hallett M
Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Neurology 2007;69(16):1580-4.
2007: Hardy John; Singleton Andrew
Reporting and interpretation of genetic variants in cases and controls.
Neurology 2007;69(1):111-2.
2007: Schymick J C; Yang Y; Andersen P M; Vonsattel J P; Greenway M; Momeni P; Elder J; Chiò A; Restagno G; Robberecht W; Dahlberg C; Mukherjee O; Goate A; Graff-Radford N; Caselli R J; Hutton M; Gass J; Cannon A; Rademakers R; Singleton A B; Hardiman O; Rothstein J; Hardy J; Traynor B J
Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes.
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):754-6.
2007: van de Leemput Joyce; Chandran Jayanth; Knight Melanie A; Holtzclaw Lynne A; Scholz Sonja; Cookson Mark R; Houlden Henry; Gwinn-Hardy Katrina; Fung Hon-Chung; Lin Xian; Hernandez Dena; Simon-Sanchez Javier; Wood Nick W; Giunti Paola; Rafferty Ian; Hardy John; Storey Elsdon; Gardner R J McKinlay; Forrest Susan M; Fisher Elizabeth M C; Russell James T; Cai Huaibin; Singleton Andrew B
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
PLoS genetics 2007;3(6):e108.
2007: Lees Andrew J; Singleton Andrew B
Clinical heterogeneity of ATP13A2 linked disease (Kufor-Rakeb) justifies a PARK designation.
Neurology 2007;68(19):1553-4.
2007: Matarín Mar; Brown W Mark; Scholz Sonja; Simón-Sánchez Javier; Fung Hon-Chung; Hernandez Dena; Gibbs J Raphael; De Vrieze Fabienne Wavrant; Crews Cynthia; Britton Angela; Langefeld Carl D; Brott Thomas G; Brown Robert D; Worrall Bradford B; Frankel Michael; Silliman Scott; Case L Douglas; Singleton Andrew; Hardy John A; Rich Stephen S; Meschia James F
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
Lancet neurology 2007;6(5):414-20.
2007: Clarimon Jordi; Gray Rebecca R; Williams Lindsey N; Enoch Mary-Anne; Robin Robert W; Albaugh Bernard; Singleton Andrew; Goldman David; Mulligan Connie J
Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations.
Alcoholism, clinical and experimental research 2007;31(4):546-54.
2007: Schymick Jennifer C; Scholz Sonja W; Fung Hon-Chung; Britton Angela; Arepalli Sampath; Gibbs J Raphael; Lombardo Federica; Matarin Mar; Kasperaviciute Dalia; Hernandez Dena G; Crews Cynthia; Bruijn Lucie; Rothstein Jeffrey; Mora Gabriele; Restagno Gabriella; Chiò Adriano; Singleton Andrew; Hardy John; Traynor Bryan J
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2007;6(4):322-8.
2007: Worrall Bradford B; Brott Thomas G; Brown Robert D; Brown W Mark; Rich Stephen S; Arepalli Sampath; Wavrant-De Vrièze Fabienne; Duckworth Jaime; Singleton Andrew B; Hardy John; Meschia James F;
IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations.
Stroke; a journal of cerebral circulation 2007;38(4):1189-96.
2007: Lippa C F; Duda J E; Grossman M; Hurtig H I; Aarsland D; Boeve B F; Brooks D J; Dickson D W; Dubois B; Emre M; Fahn S; Farmer J M; Galasko D; Galvin J E; Goetz C G; Growdon J H; Gwinn-Hardy K A; Hardy J; Heutink P; Iwatsubo T; Kosaka K; Lee V M-Y; Leverenz J B; Masliah E; McKeith I G; Nussbaum R L; Olanow C W; Ravina B M; Singleton A B; Tanner C M; Trojanowski J Q; Wszolek Z K;
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Xiromerisiou G; Hadjigeorgiou G M; Eerola J; Fernandez H H; Tsimourtou V; Mandel R; Hellström O; Gwinn-Hardy K; Okun M S; Tienari P J; Singleton A B
BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups.
Neuroscience letters 2007;415(1):59-63.
2007: Wiklund P G; Brown W M; Brott T G; Stegmayr B; Brown R D; Nilsson-Ardnor S; Hardy J A; Kissela B M; Singleton A; Holmberg D; Rich S S; Meschia J F
Lack of aggregation of ischemic stroke subtypes within affected sibling pairs.
Neurology 2007;68(6):427-31.
2007: Low Nancy; Singleton Andrew
Establishing the genetic heterogeneity of familial hemiplegic migraine.
Brain : a journal of neurology 2007;130(Pt 2):312-3.
2007: Xiromerisiou G; Hadjigeorgiou G M; Gourbali V; Johnson J; Papakonstantinou I; Papadimitriou A; Singleton A B
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2007;14(1):7-11.
2007: Clarimon Jordi; Brancati Francesco; Peckham Elizabeth; Valente Enza Maria; Dallapiccola Bruno; Abruzzese Giovanni; Girlanda Paolo; Defazio Giovanni; Berardelli Alfredo; Hallett Mark; Singleton Andrew B
Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm.
Movement disorders : official journal of the Movement Disorder Society 2007;22(2):162-6.
2007: Simon-Sanchez Javier; Scholz Sonja; Fung Hon-Chung; Matarin Mar; Hernandez Dena; Gibbs J Raphael; Britton Angela; de Vrieze Fabienne Wavrant; Peckham Elizabeth; Gwinn-Hardy Katrina; Crawley Anthony; Keen Judith C; Nash Josefina; Borgaonkar Digamber; Hardy John; Singleton Andrew
Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals.
Human molecular genetics 2007;16(1):1-14.
2007: Hanagasi Hasmet Ayhan; Lees Andrew; Johnson Janel O; Singleton Andrew; Emre Murat
Smoking-responsive juvenile-onset Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2007;22(1):115-9.
2007: Gwinn Katrina; Corriveau Roderick A; Mitsumoto Hiroshi; Bednarz Kate; Brown Robert H; Cudkowicz Merit; Gordon Paul H; Hardy John; Kasarskis Edward J; Kaufmann Petra; Miller Robert; Sorenson Eric; Tandan Rup; Traynor Bryan J; Nash Josefina; Sherman Alex; Mailman Matthew D; Ostell James; Bruijn Lucie; Cwik Valerie; Rich Stephen S; Singleton Andrew; Refolo Larry; Andrews Jaime; Zhang Ran; Conwit Robin; Keller Margaret A;
Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
PloS one 2007;2(12):e1254.
2007: Johnson Janel; Paisán-Ruíz Coro; Lopez Grisel; Crews Cynthia; Britton Angela; Malkani Roniel; Evans E Whitney; McInerney-Leo Aideen; Jain Shushant; Nussbaum Robert L; Foote Kelly D; Mandel Ronald J; Crawley Anthony; Reimsnider Sharon; Fernandez Hubert H; Okun Michael S; Gwinn-Hardy Katrina; Singleton Andrew B
Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Neuro-degenerative diseases 2007;4(5):386-91.
2006: Scholz S; Mandel R J; Fernandez H H; Foote K D; Rodriguez R L; Barton E; Munson S; Singleton A; Okun M S
LRRK2 mutations in a clinic-based cohort of Parkinson's disease.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2006;13(12):1298-301.
2006: Fung Hon-Chung; Scholz Sonja; Matarin Mar; Simón-Sánchez Javier; Hernandez Dena; Britton Angela; Gibbs J Raphael; Langefeld Carl; Stiegert Matt L; Schymick Jennifer; Okun Michael S; Mandel Ronald J; Fernandez Hubert H; Foote Kelly D; Rodríguez Ramón L; Peckham Elizabeth; De Vrieze Fabienne Wavrant; Gwinn-Hardy Katrina; Hardy John A; Singleton Andrew
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2006;5(11):911-6.
2006: Simón-Sánchez Javier; Martí-Massó José-Félix; Sánchez-Mut José Vicente; Paisán-Ruiz Coro; Martínez-Gil Angel; Ruiz-Martínez Javier; Sáenz Amets; Singleton Andrew B; López de Munain Adolfo; Pérez-Tur Jordi
Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques.
Movement disorders : official journal of the Movement Disorder Society 2006;21(11):1954-9.
2006: Hardy John; Cai Huaiban; Cookson Mark R; Gwinn-Hardy Katrina; Singleton Andrew
Genetics of Parkinson's disease and parkinsonism.
Annals of neurology 2006;60(4):389-98.
2006: Gibbs J Raphael; Singleton Andrew
Application of genome-wide single nucleotide polymorphism typing: simple association and beyond.
PLoS genetics 2006;2(10):e150.
2006: Matarin M M; Singleton A B; Houlden H
PANK2 gene analysis confirms genetic heterogeneity in neurodegeneration with brain iron accumulation (NBIA) but mutations are rare in other types of adult neurodegenerative disease.
Neuroscience letters 2006;407(2):162-5.
2006: Shatunov Alexey; Sambuughin Nyamkhishig; Jankovic Joseph; Elble Rodger; Lee Hee Suk; Singleton Andrew B; Dagvadorj Ayush; Ji Jay; Zhang Yiping; Kimonis Virginia E; Hardy John; Hallett Mark; Goldfarb Lev G
Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.
Brain : a journal of neurology 2006;129(Pt 9):2318-31.
2006: Eblan Michael J; Scholz Sonja; Stubblefield Barbara; Gutti Usha; Goker-Alpan Ozlem; Hruska Kathleen S; Singleton Andrew B; Sidransky Ellen
Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.
Neuroscience letters 2006;404(1-2):163-5.
2006: Greggio Elisa; Jain Shushant; Kingsbury Ann; Bandopadhyay Rina; Lewis Patrick; Kaganovich Alice; van der Brug Marcel P; Beilina Alexandra; Blackinton Jeff; Thomas Kelly Jean; Ahmad Rili; Miller David W; Kesavapany Sashi; Singleton Andrew; Lees Andrew; Harvey Robert J; Harvey Kirsten; Cookson Mark R
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Neurobiology of disease 2006;23(2):329-41.
2006: Clarimon Jordi; Scholz Sonja; Fung Hon-Chung; Hardy John; Eerola Johanna; Hellstrom Olli; Chen Chiung-Mei; Wu Yih-Ru; Tienari Pentti J; Singleton Andrew
Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease.
American journal of human genetics 2006;78(6):1082-4; author reply 1092-4.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Hernandez Dena; Singleton Andrew; Wu Yih-Ru
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(6):880-1.
2006: Clarimón Jordi; Eerola Johanna; Hellström Olli; Peuralinna Terhi; Tienari Pentti J; Singleton Andrew B
Assessment of PINK1 (PARK6) polymorphisms in Finnish PD.
Neurobiology of aging 2006;27(6):906-7.
2006: Momeni Parastoo; Cairns Nigel J; Perry Robert H; Bigio Eileen H; Gearing Marla; Singleton Andrew B; Hardy John
Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID).
Neurobiology of aging 2006;27(5):778.e1-778.e6.
2006: Hadjigeorgiou Georgios M; Xiromerisiou Georgia; Gourbali Vanessa; Aggelakis Kostantinos; Scarmeas Nikolaos; Papadimitriou Alexandros; Singleton Andrew
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Movement disorders : official journal of the Movement Disorder Society 2006;21(4):534-9.
2006: Hague S; Klaffke S; Clarimon J; Hemmer B; Singleton A; Kupsch A; Bandmann O
Lack of association with TorsinA haplotype in German patients with sporadic dystonia.
Neurology 2006;66(6):951-2.
2006: Scholz Sonja W; Xiromerisiou Georgia; Fung Hon C; Eerola Johanna; Hellström Olli; Papadimitriou Alexandros; Hadjigeorgiou Georgios M; Tienari Pentti J; Fernandez Hubert H; Mandel Ronald; Okun Michael S; Gwinn-Hardy Katharina; Singleton Andrew B
The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.
Neuroscience letters 2006;395(3):227-9.
2006: Paisán-Ruíz C; Evans E W; Jain S; Xiromerisiou G; Gibbs J R; Eerola J; Gourbali V; Hellström O; Duckworth J; Papadimitriou A; Tienari P J; Hadjigeorgiou G M; Singleton A B
Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium.
Journal of medical genetics 2006;43(2):e9.
2006: Nishioka Kenya; Hayashi Shin; Farrer Matthew J; Singleton Andrew B; Yoshino Hiroyo; Imai Hisamasa; Kitami Toshiaki; Sato Kenichi; Kuroda Ryu; Tomiyama Hiroyuki; Mizoguchi Koichi; Murata Miho; Toda Tatsushi; Imoto Issei; Inazawa Johji; Mizuno Yoshikuni; Hattori Nobutaka
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.
Annals of neurology 2006;59(2):298-309.
2006: Eblan Michael J; Nguyen Joann; Ziegler Shira G; Lwin Alicia; Hanson Melissa; Gallardo Marisol; Weiser Roberto; De Lucca Marisel; Singleton Andrew; Sidransky Ellen
Glucocerebrosidase mutations are also found in subjects with early-onset parkinsonism from Venezuela.
Movement disorders : official journal of the Movement Disorder Society 2006;21(2):282-3.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Singleton Andrew B; Lee-Chen Guey-Jen; Wu Yih-Ru
Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan.
Neuroscience letters 2006;394(1):33-6.
2006: Hardy John; Scholz Sonja; Evans Whitney; Goldfarb Lev; Singleton Andrew
Prion genotypes in Central America suggest selection for the V129 allele.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(1):33-5.
2006: Garcia Michael L; Singleton Andrew B; Hernandez Dena; Ward Christopher M; Evey Crystal; Sapp Peter A; Hardy John; Brown Robert H; Cleveland Don W
Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis.
Neurobiology of disease 2006;21(1):102-9.
2006: Fung H C; Xiromerisiou G; Gibbs J R; Wu Y R; Eerola J; Gourbali V; Hellström O; Chen C M; Duckworth J; Papadimitriou A; Tienari P J; Hadjigeorgiou G M; Hardy J; Singleton A B
Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts.
Neuro-degenerative diseases 2006;3(6):327-33.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Singleton Andrew B; Wu Yih-Ru
A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.
BMC neurology 2006;6():47.
2006: Momeni Parastoo; Schymick Jennifer; Jain Shushant; Cookson Mark R; Cairns Nigel J; Greggio Elisa; Greenway Matthew J; Berger Stephen; Pickering-Brown Stuart; Chiò Adriano; Fung Hon Chung; Holtzman David M; Huey Edward D; Wassermann Eric M; Adamson Jennifer; Hutton Michael L; Rogaeva Ekaterina; St George-Hyslop Peter; Rothstein Jeffrey D; Hardiman Orla; Grafman Jordan; Singleton Andrew; Hardy John; Traynor Bryan J
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2006: Guerreiro Rita J; Bras Jose M; Santana Isabel; Januario Cristina; Santiago Beatriz; Morgadinho Ana S; Ribeiro Maria H; Hardy John; Singleton Andrew; Oliveira Catarina
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort.
BMC neurology 2006;6():24.
2005: Cookson Mark R; Xiromerisiou Georgia; Singleton Andrew
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.
Current opinion in neurology 2005;18(6):706-11.
2005: Khan Naheed L; Jain Shushant; Lynch John M; Pavese Nicola; Abou-Sleiman Patrick; Holton Janice L; Healy Daniel G; Gilks William P; Sweeney Mary G; Ganguly Milan; Gibbons Vaneesha; Gandhi Sonia; Vaughan Jenny; Eunson Louise H; Katzenschlager Regina; Gayton Juliet; Lennox Graham; Revesz Tamas; Nicholl David; Bhatia Kailash P; Quinn Niall; Brooks David; Lees Andrew J; Davis Mary B; Piccini Paola; Singleton Andrew B; Wood Nicholas W
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.
Brain : a journal of neurology 2005;128(Pt 12):2786-96.
2005: Bras Jose Miguel; Guerreiro Rita Joao; Ribeiro Maria Helena; Januario Cristina; Morgadinho Ana; Oliveira Catarina Resende; Cunha Luis; Hardy John; Singleton Andrew
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1653-5.
2005: Hernandez Dena; Paisan Ruiz Coro; Crawley Anthony; Malkani Roneil; Werner John; Gwinn-Hardy Katrina; Dickson Dennis; Wavrant Devrieze Fabienne; Hardy John; Singleton Andrew
The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases.
Neuroscience letters 2005;389(3):137-9.
2005: Momeni Parastoo; Lu Chin-Song; Chou Yah-Huei Wu; Chang Hsiu-Chen; Chen Rou-Shayn; Chen Chiung-Chu; Hsu Jin-Tian; Singleton Andrew; Hardy John
Taiwanese cases of SCA2 are derived from a single founder.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1633-6.
2005: Plummer C; Bradfield J; Singleton A B; Hernandez D; Singleton A A; O'sullivan J
First case report of X linked dystonia parkinsonism (XDP) or 'lubag' in Australia.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2005;12(8):945-6.
2005: Paisán-Ruíz C; Lang A E; Kawarai T; Sato C; Salehi-Rad S; Fisman G K; Al-Khairallah T; St George-Hyslop P; Singleton A; Rogaeva E
LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Neurology 2005;65(5):696-700.
2005: Meschia James F; Brott Thomas G; Brown Robert D; Crook Richard; Worrall Bradford B; Kissela Brett; Brown W Mark; Rich Stephen S; Case L Douglas; Evans E Whitney; Hague Stephen; Singleton Andrew; Hardy John;
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
Annals of neurology 2005;58(3):351-61.
2005: Singleton Andrew B
Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin.
Trends in neurosciences 2005;28(8):416-21.
2005: Martinez Maria; Brice Alexis; Vaughan Jenny R; Zimprich Alexander; Breteler Monique M B; Meco Giuseppe; Filla Alessandro; Farrer Matthew J; Bétard Christine; Singleton Andrew; Hardy John; De Michele Giuseppe; Bonifati Vincenzo; Oostra Ben A; Gasser Thomas; Wood Nick W; Dürr Alexandra
Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):72-4.
2005: Simon-Sanchez Javier; Hanson Melissa; Singleton Amanda; Hernandez Dena; McInerney Aideen; Nussbaum Robert; Werner John; Gallardo Marisol; Weiser Roberto; Gwinn-Hardy Katrina; Singleton Andrew B; Clarimon Jordi
Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.
Neuroscience letters 2005;382(1-2):191-4.
2005: Clarimon Jordi; Johnson Janel; Djaldetti Ruth; Hernandez Dena; Hattori Nobutaka; Sroka Hava; Barhom Yael; Singleton Andrew
Mutation of the Parkin gene in a Persian family: clinical progression over a 40-year period.
Movement disorders : official journal of the Movement Disorder Society 2005;20(7):887-90.
2005: Clarimon Jordi; Asgeirsson Hilmir; Singleton Andrew; Jakobsson Finnbogi; Hjaltason Haukur; Hardy John; Sveinbjornsdottir Sigurlaug
Torsin A haplotype predisposes to idiopathic dystonia.
Annals of neurology 2005;57(5):765-7.
2005: Greggio Elisa; Bergantino Elisabetta; Carter Donald; Ahmad Rili; Costin Gertrude-Emilia; Hearing Vincent J; Clarimon Jordi; Singleton Andrew; Eerola Johanna; Hellström Olli; Tienari Pentti J; Miller David W; Beilina Alexandra; Bubacco Luigi; Cookson Mark R
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.
Journal of neurochemistry 2005;93(1):246-56.
2005: Khan Naheed L; Horta Wagner; Eunson Louise; Graham Elizabeth; Johnson Janel O; Chang Shannon; Davis Mary; Singleton Andrew; Wood Nicholas W; Lees Andrew J
Parkin disease in a Brazilian kindred: Manifesting heterozygotes and clinical follow-up over 10 years.
Movement disorders : official journal of the Movement Disorder Society 2005;20(4):479-84.
2005: Hernandez Dena G; Paisán-Ruíz Coro; McInerney-Leo Aideen; Jain Shushant; Meyer-Lindenberg Andreas; Evans E Whitney; Berman Karen F; Johnson Janel; Auburger Georg; Schäffer Alejandro A; Lopez Grisel J; Nussbaum Robert L; Singleton Andrew B
Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Annals of neurology 2005;57(3):453-6.
2005: Miller David W; Crawley Anthony; Gwinn-Hardy Katrina; Lopez Grisel; Nussbaum Robert; Cookson Mark R; Singleton Andrew B; Hardy John; Dogu Okan
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.
Neuroscience letters 2005;374(3):189-91.
2005: Clarimon Jordi; Johnson Janel; Dogu Okan; Horta Wagner; Khan Naheed; Lees Andrew J; Hardy John; Singleton Andrew
Defining the ends of Parkin exon 4 deletions in two different families with Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;133B(1):120-3.
2005: Gilks William P; Abou-Sleiman Patrick M; Gandhi Sonia; Jain Shushant; Singleton Andrew; Lees Andrew J; Shaw Karen; Bhatia Kailash P; Bonifati Vincenzo; Quinn Niall P; Lynch John; Healy Daniel G; Holton Janice L; Revesz Tamas; Wood Nicholas W
A common LRRK2 mutation in idiopathic Parkinson's disease.
Lancet 2005;365(9457):415-6.
2005: Nichols William C; Pankratz Nathan; Hernandez Dena; Paisán-Ruíz Coro; Jain Shushant; Halter Cheryl A; Michaels Veronika E; Reed Terry; Rudolph Alice; Shults Clifford W; Singleton Andrew; Foroud Tatiana;
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.
Lancet 2005;365(9457):410-2.
2005: Buervenich Silvia; Carmine Andrea; Galter Dagmar; Shahabi Haydeh N; Johnels Bo; Holmberg Björn; Ahlberg Jarl; Nissbrandt Hans; Eerola Johanna; Hellström Olli; Tienari Pentti J; Matsuura Tohru; Ashizawa Tetsuo; Wüllner Ullrich; Klockgether Thomas; Zimprich Alexander; Gasser Thomas; Hanson Melissa; Waseem Shamaila; Singleton Andrew; McMahon Francis J; Anvret Maria; Sydow Olof; Olson Lars
A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.
Archives of neurology 2005;62(1):74-8.
2005: Clarimon Jordi; Xiromerisiou Georgia; Eerola Johanna; Gourbali Vanesa; Hellström Olli; Dardiotis Euthimios; Peuralinna Terhi; Papadimitriou Alexandros; Hadjigeorgiou George M; Tienari Pentti J; Singleton Andrew B
Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.
BMC neurology 2005;5():11.
2004: Rogaeva Ekaterina; Johnson Janel; Lang Anthony E; Gulick Cindy; Gwinn-Hardy Katrina; Kawarai Toshitaka; Sato Christine; Morgan Angharad; Werner John; Nussbaum Robert; Petit Agnes; Okun Michael S; McInerney Aideen; Mandel Ronald; Groen Justus L; Fernandez Hubert H; Postuma Ron; Foote Kelly D; Salehi-Rad Shabnam; Liang Yan; Reimsnider Sharon; Tandon Anurag; Hardy John; St George-Hyslop Peter; Singleton Andrew B
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology 2004;61(12):1898-904.
2004: Shatunov A; Fridman E A; Pagan F I; Leib J; Singleton A; Hallett M; Goldfarb L G
Small de novo duplication in the repeat region of the TATA-box-binding protein gene manifest with a phenotype similar to variant Creutzfeldt-Jakob disease.
Clinical genetics 2004;66(6):496-501.
2004: Busby J; O'Brien K K; Gibson A M; McKeith I G; Perry R H; Hardy J A; Singleton A B; Morris C M
Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene.
Neurogenetics 2004;5(4):251-2.
2004: Hanson Melissa; Honour Melissa; Singleton Amanda; Crawley Anthony; Singleton Andrew; Hardy John; Gwinn-Hardy Katrina
Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features.
Journal of neurology 2004;251(11):1398-401.
2004: Hanson Melissa; Honour Melissa; Singleton Amanda; Crawley Anthony; Singleton Andrew; Hardy John; Gwinn-Hardy Katrina
Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features.
Journal of neurology 2004;251(11):1398-401.
2004: Paisán-Ruíz Coro; Jain Shushant; Evans E Whitney; Gilks William P; Simón Javier; van der Brug Marcel; López de Munain Adolfo; Aparicio Silvia; Gil Angel Martínez; Khan Naheed; Johnson Janel; Martinez Javier Ruiz; Nicholl David; Carrera Itxaso Marti; Pena Amets Saénz; de Silva Rohan; Lees Andrew; Martí-Massó José Félix; Pérez-Tur Jordi; Wood Nick W; Singleton Andrew B
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.
Neuron 2004;44(4):595-600.
2004: Singleton Andrew
What does PINK1 mean for Parkinson diseases?
Neurology 2004;63(8):1350-1.
2004: Evidente Virgilio Gerald H; Esteban Raymund P; Hernandez Jose Luis; Natividad Filipinas F; Advincula Joel; Gwinn-Hardy Katrina; Hardy John; Singleton Amanda; Singleton Andrew
Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.
Parkinsonism & related disorders 2004;10(7):407-10.
2004: Evidente Virgilio Gerald H; Esteban Raymund P; Hernandez Jose Luis; Natividad Filipinas F; Advincula Joel; Gwinn-Hardy Katrina; Hardy John; Singleton Amanda; Singleton Andrew
Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.
Parkinsonism & related disorders 2004;10(7):407-10.
2004: Evans Whitney; Fung Hon Chung; Steele John; Eerola Johanna; Tienari Pentti; Pittman Alan; Silva Rohan de; Myers Amanda; Vrieze Fabienne Wavrant-De; Singleton Andrew; Hardy John
The tau H2 haplotype is almost exclusively Caucasian in origin.
Neuroscience letters 2004;369(3):183-5.
2004: Singleton Andrew; Gwinn-Hardy Katrina
Parkinson's disease and dementia with Lewy bodies: a difference in dose?
Lancet 2004;364(9440):1105-7.
2004: Clarimon Jordi; Eerola Johanna; Hellström Olli; Tienari Pentti J; Singleton Andrew
Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finnish population.
Neuroscience letters 2004;367(2):168-70.
2004: O'Farrell Casey; Lockhart Paul J; Lincoln Sarah; De Lucia Michael; Singleton Andrew B; Dickson Dennis W; Cookson Mark R
Biochemical characterization of torsinB.
Brain research. Molecular brain research 2004;127(1-2):1-9.
2004: Johnson J; Hague S M; Hanson M; Gibson A; Wilson K E; Evans E W; Singleton A A; McInerney-Leo A; Nussbaum R L; Hernandez D G; Gallardo M; McKeith I G; Burn D J; Ryu M; Hellstrom O; Ravina B; Eerola J; Perry R H; Jaros E; Tienari P; Weiser R; Gwinn-Hardy K; Morris C M; Hardy J; Singleton A B
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
Neurology 2004;63(3):554-6.
2004: Dogu Okan; Johnson Janel; Hernandez Dena; Hanson Melissa; Hardy John; Apaydin Hulya; Ozekmekçi Sibel; Sevim Serhan; Gwinn-Hardy Katrina; Singleton Andrew
A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):812-6.
2004: Clark Lorraine N; Afridi Shehla; Mejia-Santana Helen; Harris Juliette; Louis Elan D; Cote Lucien J; Andrews Howard; Singleton Andrew; Wavrant De-Vrieze Fabienne; Hardy John; Mayeux Richard; Fahn Stanley; Waters Cheryl; Ford Blair; Frucht Steven; Ottman Ruth; Marder Karen
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):796-800.
2004: Johnson Janel; Ostojic Jovanka; Lannfelt Lars; Glaser Anna; Basun Hans; Rogaeva Ekaterina; Kawarai Toshitaka; Bruni Amalia; St George Hyslop Peter H; Goate Alison; Pastor Pau; Chakraverty Sumi; Norton Joanne; Morris John C; Hardy John; Singleton Andrew
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.
Neuroscience letters 2004;363(2):99-101.
2004: Miller D W; Hague S M; Clarimon J; Baptista M; Gwinn-Hardy K; Cookson M R; Singleton A B
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
Neurology 2004;62(10):1835-8.
2004: Singleton Andrew; Myers Amanda; Hardy John
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases.
Human molecular genetics 2004;13 Spec No 1():R123-6.
2004: Singleton Amanda; Gwinn-Hardy Katrina; Sharabi Yehonotan; Li Sheng-Ting; Holmes Courtney; Dendi Raghuveer; Hardy John; Singleton Andrew; Crawley Anthony; Goldstein David S
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
Brain : a journal of neurology 2004;127(Pt 4):768-72.
2004: Singleton Amanda; Gwinn-Hardy Katrina; Sharabi Yehonotan; Li Sheng-Ting; Holmes Courtney; Dendi Raghuveer; Hardy John; Singleton Andrew; Crawley Anthony; Goldstein David S
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
Brain : a journal of neurology 2004;127(Pt 4):768-72.
2004: Hague S; Peuralinna T; Eerola J; Hellström O; Tienari P J; Singleton A B
Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease.
Neurology 2004;62(4):635-6.
2004: Bruno Michiko K; Ravina Bernard; Garraux Gaetan; Hallett Mark; Ptacek Louis; Singleton Amanda; Johnson Janel; Singleton Andrew; Hanson Melissa; Considine Elaine; Gwinn-Hardy Katrina
Exercise-induced dystonia as a preceding symptom of familial Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2004;19(2):228-30.
2004: Bruno Michiko K; Ravina Bernard; Garraux Gaetan; Hallett Mark; Ptacek Louis; Singleton Amanda; Johnson Janel; Singleton Andrew; Hanson Melissa; Considine Elaine; Gwinn-Hardy Katrina
Exercise-induced dystonia as a preceding symptom of familial Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2004;19(2):228-30.
2004: Singleton Andrew; Hague Stephen; Hernandez Dena
X-linked recessive dystonia parkinsonism (XDP; Lubag; DYT3).
Advances in neurology 2004;94():139-42.
2003: Morris Christopher M; O'Brien Kirsty K; Gibson Alison M; Hardy John A; Singleton Andrew B
Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease.
Neuroscience letters 2003;352(2):151-3.
2003: Ertekin-Taner Nilüfer; Ronald James; Asahara Hideaki; Younkin Linda; Hella Maria; Jain Shushant; Gnida Eugene; Younkin Samuel; Fadale Daniel; Ohyagi Yasumasa; Singleton Adam; Scanlin Leah; de Andrade Mariza; Petersen Ronald; Graff-Radford Neill; Hutton Michael; Younkin Steven
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Human molecular genetics 2003;12(23):3133-43.
2003: Singleton A B; Farrer M; Johnson J; Singleton A; Hague S; Kachergus J; Hulihan M; Peuralinna T; Dutra A; Nussbaum R; Lincoln S; Crawley A; Hanson M; Maraganore D; Adler C; Cookson M R; Muenter M; Baptista M; Miller D; Blancato J; Hardy J; Gwinn-Hardy K
alpha-Synuclein locus triplication causes Parkinson's disease.
Science (New York, N.Y.) 2003;302(5646):841.
2003: Eerola J; Hernandez D; Launes J; Hellström O; Hague S; Gulick C; Johnson J; Peuralinna T; Hardy J; Tienari P J; Singleton A B
Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.
Neurology 2003;61(7):1000-2.
2003: Hague Stephen; Rogaeva Ekaterina; Hernandez Dena; Gulick Cindy; Singleton Amanda; Hanson Melissa; Johnson Janel; Weiser Roberto; Gallardo Marisol; Ravina Bernard; Gwinn-Hardy Katrina; Crawley Anthony; St George-Hyslop Peter H; Lang Anthony E; Heutink Peter; Bonifati Vincenzo; Hardy John; Singleton Andrew
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation.
Annals of neurology 2003;54(2):271-4.
2003: Hague Stephen; Rogaeva Ekaterina; Hernandez Dena; Gulick Cindy; Singleton Amanda; Hanson Melissa; Johnson Janel; Weiser Roberto; Gallardo Marisol; Ravina Bernard; Gwinn-Hardy Katrina; Crawley Anthony; St George-Hyslop Peter H; Lang Anthony E; Heutink Peter; Bonifati Vincenzo; Hardy John; Singleton Andrew
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation.
Annals of neurology 2003;54(2):271-4.
2003: Hernandez Dena; Hanson Melissa; Singleton Amanda; Gwinn-Hardy Katrina; Freeman Jason; Ravina Bernard; Doheny Dana; Gallardo Marisol; Weiser Roberto; Hardy John; Singleton Andrew
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonism & related disorders 2003;9(6):317-20.
2003: Hernandez Dena; Hanson Melissa; Singleton Amanda; Gwinn-Hardy Katrina; Freeman Jason; Ravina Bernard; Doheny Dana; Gallardo Marisol; Weiser Roberto; Hardy John; Singleton Andrew
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonism & related disorders 2003;9(6):317-20.
2003: Hardy John; Singleton Andrew; Gwinn-Hardy Katrina
Ethnic differences and disease phenotypes.
Science (New York, N.Y.) 2003;300(5620):739-40.
2003: Hardy John; Cookson Mark R; Singleton Andrew
Genes and parkinsonism.
Lancet neurology 2003;2(4):221-8.
2003: Singleton Andrew
Familiality in simple and complex disease.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2003;13(2):88-90.
2003: Payami Haydeh; Nutt John; Gancher Steven; Bird Thomas; McNeal Melissa Gonzales; Seltzer William K; Hussey Jennifer; Lockhart Paul; Gwinn-Hardy Katrina; Singleton Amanda A; Singleton Andrew B; Hardy John; Farrer Matthew
SCA2 may present as levodopa-responsive parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2003;18(4):425-9.
2002: Goudreau John L; Maraganore Demetrius M; Farrer Matthew J; Lesnick Timothy G; Singleton Andrew B; Bower James H; Hardy John A; Rocca Walter A
Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1305-11.
2002: Evidente Virgilio Gerald H; Advincula Joel; Esteban Raymund; Pasco Paul; Alfon Jhoe Anthony; Natividad Filipinas F; Cuanang Joven; Luis Amado San; Gwinn-Hardy Katrina; Hardy John; Hernandez Dena; Singleton Andrew
Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1271-7.
2002: Subramony S H; Hernandez Dena; Adam Amanda; Smith-Jefferson Stephanie; Hussey Jennifer; Gwinn-Hardy Katrina; Lynch Timothy; McDaniel Olga; Hardy John; Farrer Matt; Singleton Andrew
Ethnic differences in the expression of neurodegenerative disease: Machado-Joseph disease in Africans and Caucasians.
Movement disorders : official journal of the Movement Disorder Society 2002;17(5):1068-71.
2002: O'Farrell Casey; Hernandez Dena G; Evey Crystal; Singleton Andrew B; Cookson Mark R
Normal localization of deltaF323-Y328 mutant torsinA in transfected human cells.
Neuroscience letters 2002;327(2):75-8.
2002: Amtul Zareen; Lewis Patrick A; Piper Sian; Crook Richard; Baker Matt; Findlay Kirk; Singleton Andrew; Hogg Marion; Younkin Linda; Younkin Steven G; Hardy John; Hutton Michael; Boeve Bradley F; Tang-Wai David; Golde Todd E
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Evidente Virgilio Gerald H; Gwinn-Hardy Katrina; Hardy John; Hernandez Dena; Singleton Andrew
X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype?
Movement disorders : official journal of the Movement Disorder Society 2002;17(1):200-2.
2002: Singleton Andrew B; Wharton Anna; O'Brien Kirsty K; Walker Matthew P; McKeith Ian G; Ballard Clive G; O'Brien John; Perry Robert H; Ince Paul G; Edwardson James A; Morris Christopher M
Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies.
Dementia and geriatric cognitive disorders 2002;14(4):167-75.
2001: O'Farrell C; Murphy D D; Petrucelli L; Singleton A B; Hussey J; Farrer M; Hardy J; Dickson D W; Cookson M R
Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.
Brain research. Molecular brain research 2001;97(1):94-102.
2001: Maraganore D M; Hernandez D G; Singleton A B; Farrer M J; McDonnell S K; Hutton M L; Hardy J A; Rocca W A
Case-Control study of the extended tau gene haplotype in Parkinson's disease.
Annals of neurology 2001;50(5):658-61.
2001: West A B; Zimprich A; Lockhart P J; Farrer M; Singleton A; Holtom B; Lincoln S; Hofer A; Hill L; Müller-Myhsok B; Wszolek Z K; Hardy J; Gasser T
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
European journal of human genetics : EJHG 2001;9(9):659-66.
2001: Farrer M; Chan P; Chen R; Tan L; Lincoln S; Hernandez D; Forno L; Gwinn-Hardy K; Petrucelli L; Hussey J; Singleton A; Tanner C; Hardy J; Langston J W
Lewy bodies and parkinsonism in families with parkin mutations.
Annals of neurology 2001;50(3):293-300.
2001: Farrer M; Maraganore D M; Lockhart P; Singleton A; Lesnick T G; de Andrade M; West A; de Silva R; Hardy J; Hernandez D
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
Human molecular genetics 2001;10(17):1847-51.
2001: Farrer M; Destée A; Levecque C; Singleton A; Engelender S; Becquet E; Mouroux V; Richard F; Defebvre L; Crook R; Hernandez D; Ross C A; Hardy J; Amouyel P; Chartier-Harlin M C
Genetic analysis of synphilin-1 in familial Parkinson's disease.
Neurobiology of disease 2001;8(2):317-23.
2001: Singleton A B; Gibson A M; McKeith I G; Ballard C G; Edwardson J A; Morris C M
Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies.
Neuroscience letters 2001;303(1):33-6.
2001: Gwinn-Hardy K; Singleton A; O'Suilleabhain P; Boss M; Nicholl D; Adam A; Hussey J; Critchley P; Hardy J; Farrer M
Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family.
Archives of neurology 2001;58(2):296-9.
2000: Singleton A B; Hall R; Ballard C G; Perry R H; Xuereb J H; Rubinsztein D C; Tysoe C; Matthews P; Cordell B; Kumar-Singh S; De Jonghe C; Cruts M; van Broeckhoven C; Morris C M
Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation.
Brain : a journal of neurology 2000;123 Pt 12():2467-74.
2000: Gwinn-Hardy K; Chen J Y; Liu H C; Liu T Y; Boss M; Seltzer W; Adam A; Singleton A; Koroshetz W; Waters C; Hardy J; Farrer M
Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese.
Neurology 2000;55(6):800-5.
2000: Hardy J; Singleton A
The future of genetic analysis of neurological disorders.
Neurobiology of disease 2000;7(2):65-9.
2000: Gibson A M; Singleton A B; Smith G; Woodward R; McKeith I G; Perry R H; Ince P G; Ballard C G; Edwardson J A; Morris C M
Lack of association of the alpha2-macroglobulin locus on chromosome 12 in AD.
Neurology 2000;54(2):433-8.
1999: De Jonghe C; Cruts M; Rogaeva E A; Tysoe C; Singleton A; Vanderstichele H; Meschino W; Dermaut B; Vanderhoeven I; Backhovens H; Vanmechelen E; Morris C M; Hardy J; Rubinsztein D C; St George-Hyslop P H; Van Broeckhoven C
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Singleton A B; Gibson A M; McKeith I G; Ballard C A; Perry R H; Ince P G; Edwardson J A; Morris C M
Alpha2-macroglobulin polymorphisms in Alzheimer's disease and dementia with Lewy bodies.
Neuroreport 1999;10(7):1507-10.
1999: Atkinson A; Singleton A B; Steward A; Ince P G; Perry R H; McKeith I G; Fairbairn A F; Edwardson J A; Daly A K; Morris C M
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.
Pharmacogenetics 1999;9(1):31-5.
1998: Woodward R; Singleton A B; Gibson A M; Edwardson J A; Morris C M
LRP gene and late-onset Alzheimer's disease.
Lancet 1998;352(9123):239-40.
1998: Singleton A B; Gibson A M; Edwardson J A; McKeith I G; Morris C M
Butyrylcholinesterase K: an association with dementia with Lewy bodies.
Lancet 1998;351(9118):1818.
1998: Singleton A B; Smith G; Gibson A M; Woodward R; Perry R H; Ince P G; Edwardson J A; Morris C M
No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.
Human molecular genetics 1998;7(5):937-9.
1998: Singleton A B; Thomson J H; Morris C M; Court J A; Lloyd S; Cholerton S
Lack of association between the dopamine D2 receptor gene allele DRD2*A1 and cigarette smoking in a United Kingdom population.
Pharmacogenetics 1998;8(2):125-8.
1998: Lamb H; Christie J; Singleton A B; Leake A; Perry R H; Ince P G; McKeith I G; Melton L M; Edwardson J A; Morris C M
Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Distinctions between diseases.
Neurology 1998;50(2):388-91.
1997: Thompson J; Thomas N; Singleton A; Piggott M; Lloyd S; Perry E K; Morris C M; Perry R H; Ferrier I N; Court J A
D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele.
Pharmacogenetics 1997;7(6):479-84.
1997: Singleton A B; Lamb H; Leake A; McKeith I G; Ince P G; Perry R H; Morris C M
No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.
Neuroreport 1997;8(16):3637-9.
1997: Singleton A B; Lamb H; Leake A; McKeith I G; Perry R H; Morris C M
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease.
Neuroscience letters 1997;234(1):19-22.
1997: Singleton A B; Gibson A M; Atkinson A L; Daly A; Morris C M
Presenilin polymorphisms in Alzheimer's disease.
Lancet 1997;350(9082):958-9.

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