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Glenn Sipes

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Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; W Dekant; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients.
Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.

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All Publications

2012: Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; W Dekant; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50 Suppl 3():S517-56.
2012: Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50 Suppl 2():S269-313.
2012: Donald V Belsito; David R Bickers; Magnus Bruze; Peter Calow; M L Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50 Suppl 2():S52-99.
2011: Weixi Kong; Robert K Kuester; Alfred Gallegos; I Glenn Sipes
Induction of DNA damage in human urothelial cells by the brominated flame retardant 2,2-bis(bromomethyl)-1,3-propanediol: role of oxidative stress.
Toxicology 2011;290(2-3):271-7.
2011: D Belsito; David R Bickers; M Bruze; Peter Calow; M L Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicological and dermatological assessment of macrocyclic lactone and lactide derivatives when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49 Suppl 2():S219-41.
2011: D Belsito; David R Bickers; M Bruze; Peter Calow; M Dagli; A D Fryer; Helmut Greim; Y Miyachi; Jean-Hilaire Saurat; I Glenn Sipes
A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49 Suppl 2():S256-67.
2011: Connie J Mark-Kappeler; Laurel McKee; Nivedita Sen; I Glenn Sipes; John Konhilas; Ashley Lukefahr; Patricia B Hoyer
Inhibition of ovarian KIT phosphorylation by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.
Biology of reproduction 2011;85(4):755-62.
2011: Yaofeng Cheng; Michelle J Hooth; Robert K Kuester; Lucy J Martinez-Guerrero; Stephen H Wright; I Glenn Sipes
Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1755-61.
2011: Aileen F Keating; Shannon M Fernandez; Connie J Mark-Kappeler; Nivedita Sen; I Glenn Sipes; Patricia B Hoyer
Inhibition of PIK3 signaling pathway members by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.
Biology of reproduction 2011;84(4):743-51.
2010: Connie J Mark-Kappeler; Nivedita Sen; Aileen F Keating; I Glenn Sipes; Patricia B Hoyer
Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.
Toxicology and applied pharmacology 2010;249(1):1-7.
2010: Aileen F Keating; Nivedita Sen; I Glenn Sipes; Patricia B Hoyer
Dual protective role for glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary.
Toxicology and applied pharmacology 2010;247(2):71-5.
2010: D Belsito; David R Bickers; Magnus Bruze; Peter Calow; Helmut Greim; Jon M Hanifin; Adrianne E Rogers; Jean-Hilaire Saurat; I Glenn Sipes; Hachiro Tagami
A safety assessment of branched chain saturated alcohols when used as fragrance ingredients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48 Suppl 4():S1-46.
2010: Anne Marie Api; Donald Belsito; David Bickers; Magnus Bruze; Peter Calow; Helmut Greim; Jon M Hanifin; Pauline M McNamee; Adrianne E Rogers; Jean-Hilaire Saurat; I Glenn Sipes; Hachiro Tagami
Quantitative risk assessment of contact sensitization: clinical data to assess utility of the model.
Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group 2010;21(4):207-13.
2010: Golriz Rad; Simone I Hoehle; Robert K Kuester; I Glenn Sipes
In vitro glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(6):957-62.
2009: Aileen F Keating; Connie J Mark; Nivedita Sen; I Glenn Sipes; Patricia B Hoyer
Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.
Toxicology and applied pharmacology 2009;241(2):127-34.
2009: G A Knudsen; Y Cheng; Robert K Kuester; M J Hooth; I Glenn Sipes
Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2171-7.
2009: Y Cheng; Stephen H Wright; M J Hooth; I Glenn Sipes
Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):909-16.
2009: Simone I Hoehle; Gabriel A Knudsen; J Michael Sanders; I Glenn Sipes
Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):408-16.
2009: Yoshiyuki Igawa; Aileen F Keating; Kathila S Rajapaksa; I Glenn Sipes; Patricia B Hoyer
Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system.
Toxicology and applied pharmacology 2009;234(3):361-9.
2008: Aileen F Keating; Kathila S Rajapaksa; I Glenn Sipes; Patricia B Hoyer
Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2008;105(2):351-9.
2008: Aileen F Keating; I Glenn Sipes; Patricia B Hoyer
Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice.
Toxicology and applied pharmacology 2008;230(1):109-16.
2008: Daniel Isola; Ian Kimber; Katherine Sarlo; Jon Lalko; I Glenn Sipes
Chemical respiratory allergy and occupational asthma: what are the key areas of uncertainty?
Journal of applied toxicology : JAT 2008;28(3):249-53.
2008: I Glenn Sipes; G A Knudsen; Robert K Kuester
The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F-344 rats and female B6C3F1 mice.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):284-93.
2007: Robert K Kuester; I Glenn Sipes
Prediction of metabolic clearance of bisphenol A (4,4 '-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1910-5.
2007: Ann M Mason; Christopher J Borgert; James S Bus; M Moiz Mumtaz; Jane Ellen Simmons; I Glenn Sipes
Improving the scientific foundation for mixtures joint toxicity and risk assessment: contributions from the SOT mixtures project--introduction.
Toxicology and applied pharmacology 2007;223(2):99-103.
2007: G A Knudsen; L M Jacobs; Robert K Kuester; I Glenn Sipes
Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats.
Toxicology 2007;237(1-3):158-67.
2007: Kathila S Rajapaksa; Ellen A Cannady; I Glenn Sipes; Patricia B Hoyer
Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites.
Toxicology and applied pharmacology 2007;221(2):215-21.
2007: Patricia B Hoyer; I Glenn Sipes
Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study.
Birth defects research. Part B, Developmental and reproductive toxicology 2007;80(2):113-25.
2007: Robert K Kuester; Anikó M Sólyom; Veronica P Rodriguez; I Glenn Sipes
The effects of dose, route, and repeated dosing on the disposition and kinetics of tetrabromobisphenol A in male F-344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2007;96(2):237-45.
2007: Kathila S Rajapaksa; I Glenn Sipes; Patricia B Hoyer
involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene.
Toxicological sciences : an official journal of the Society of Toxicology 2007;96(2):327-34.
2006: Julie E Goodman; Ernest E McConnell; I Glenn Sipes; Raphael J Witorsch; Tracey M Slayton; Carrie J Yu; Ari S Lewis; Lorenz R Rhomberg
An updated weight of the evidence evaluation of reproductive and developmental effects of low doses of bisphenol A.
Critical reviews in toxicology 2006;36(5):387-457.
2005: Kary E Thompson; Shannon M Bourguet; Patricia J Christian; Jamie C Benedict; I Glenn Sipes; Jodi A Flaws; Patricia B Hoyer
Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.
Toxicology and applied pharmacology 2005;203(2):114-23.
2004: Patrick J Devine; I Glenn Sipes; Patricia B Hoyer
Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexene diepoxide.
Reproductive toxicology (Elmsford, N.Y.) 2004;19(1):71-7.
2004: Ronald Hines; Jane Adams; Germaine M Buck; Willem Faber; Joseph F Holson; Sandra W Jacobson; Martin Keszler; Kenneth McMartin; Richard Segraves; Lynn T Singer; I Glenn Sipes; Paige L Williams
NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine.
Birth defects research. Part B, Developmental and reproductive toxicology 2004;71(4):193-280.
2004: C J Sweet; Anikó M Sólyom; I Glenn Sipes
Absorption and elimination of D and C Red No. 28 in male F-344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(4):641-8.
2003: Ellen A Cannady; Cheryl A Dyer; Patricia J Christian; I Glenn Sipes; Patricia B Hoyer
Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):423-30.
2002: Jason S Halladay; Carl R Mackerer; Lorraine E Twerdok; I Glenn Sipes
Comparative pharmacokinetic and disposition studies of [1-14C]1-eicosanylcyclohexane, a surrogate mineral hydrocarbon, in female Fischer-344 and Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1470-7.
2002: DA Badger; R L Smith; J Bao; Robert K Kuester; I Glenn Sipes
Disposition and metabolism of isoeugenol in the male Fischer 344 rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(12):1757-65.
2002: Lorretta Mayor; Nicole A Pearsall; Patricia J Christian; Patrick J Devine; Claire M Payne; Margaret K McCuskey; Samuel L Marion; I Glenn Sipes; Patricia B Hoyer
Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(6):775-81.
2002: J J Pritchett; Robert K Kuester; I Glenn Sipes
Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(11):1180-5.
2002: Patrick J Devine; I Glenn Sipes; Michael Skinner; Patricia B Hoyer
Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide.
Toxicology and applied pharmacology 2002;184(2):107-15.
2002: Xiaoming Hu; Jodi A Flaws; I Glenn Sipes; Patricia B Hoyer
Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats.
Biology of reproduction 2002;67(3):718-24.
2002: Ellen A Cannady; Cheryl A Dyer; Patricia J Christian; I Glenn Sipes; Patricia B Hoyer
Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):24-31.
2002: Kary E Thompson; I Glenn Sipes; Ben D Greenstein; Patricia B Hoyer
17beta-estradiol affords protection against 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in Fischer-344 rats.
Endocrinology 2002;143(3):1058-65.
2002: Robert K Kuester; Michael P Waalkes; Peter L Goering; Ben L Fisher; Robert S McCuskey; I Glenn Sipes
Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(1):151-9.
2001: Xiaoming Hu; Patricia J Christian; I Glenn Sipes; Patricia B Hoyer
Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats.
Biology of reproduction 2001;65(5):1489-95.
2001: SM Fontaine; Patricia B Hoyer; James Halpert; I Glenn Sipes
Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(9):1236-42.
2001: Patrick J Devine; I Glenn Sipes; Patricia B Hoyer
Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries.
Toxicological sciences : an official journal of the Society of Toxicology 2001;62(2):315-20.
2001: SM Fontaine; Patricia B Hoyer; I Glenn Sipes
Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcyclohexene.
Life sciences 2001;69(8):923-34.
2001: Xiaoming Hu; Patricia J Christian; Kary E Thompson; I Glenn Sipes; Patricia B Hoyer
Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades.
Biology of reproduction 2001;65(1):87-93.
2001: SM Fontaine; Eugene A. Mash Jr.; Patricia B Hoyer; I Glenn Sipes
Stereochemical aspects of vinylcyclohexene bioactivation in rodent hepatic microsomes and purified human cytochrome P450 enzyme systems.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):179-84.
2001: Patricia B Hoyer; Ellen A Cannady; N A Kroeger; I Glenn Sipes
Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical.
Advances in experimental medicine and biology 2001;500():73-81.
2001: Patricia B Hoyer; Patrick J Devine; Xiaoming Hu; Kary E Thompson; I Glenn Sipes
Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model.
Toxicologic pathology 2001;29(1):91-9.
2000: Jennifer L Burkey; John-Michael Sauer; Charlene A McQueen; I Glenn Sipes
Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol.
Mutation research 2000;453(1):25-33.
2000: S M Borman; Patricia J Christian; I Glenn Sipes; Patricia B Hoyer
Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index.
Toxicology and applied pharmacology 2000;167(3):191-8.
2000: H Ishiyama; NC Hoglen; I Glenn Sipes
Diethyldithiocarbamate enhances production of nitric oxide and TNF-alpha by lipopolysaccharide-stimulated rat Kupffer cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(1):206-14.
2000: Husam S Younis; NC Hoglen; Robert K Kuester; L Gunawardhana; I Glenn Sipes
1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats.
Toxicology and applied pharmacology 2000;163(2):141-8.
1999: J S Halladay; John-Michael Sauer; I Glenn Sipes
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1456-65.
1999: S M Borman; B J VanDePol; S Kao; Kary E Thompson; I Glenn Sipes; Patricia B Hoyer
A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles.
Toxicology and applied pharmacology 1999;158(3):244-52.
1999: J K Doerr-Stevens; J Liu; GJ Stevens; J C Kraner; SM Fontaine; James Halpert; I Glenn Sipes
Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):281-7.
1999: S W Kao; I Glenn Sipes; Patricia B Hoyer
Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice.
Reproductive toxicology (Elmsford, N.Y.) 1999;13(1):67-75.
1998: NC Hoglen; Husam S Younis; D P Hartley; L Gunawardhana; R Clark Lantz; I Glenn Sipes
1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(2):376-85.
1998: NC Hoglen; S P Regan; J L Hensel; Husam S Younis; John-Michael Sauer; D R Steup; M J Miller; S J Waterman; L E Twerdok; I Glenn Sipes
Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):176-84.
1998: J Bao; John-Michael Sauer; RL Smith; Robert K Kuester; MJ Kattnig; I Glenn Sipes
Sulfhydryl-dependent biotransformation and macromolecular binding of 1,2-dibromo-2,4-dicyanobutane in blood.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(10):1001-7.
1998: John-Michael Sauer; RL Smith; J Bao; MJ Kattnig; Robert K Kuester; I Glenn Sipes
Metabolic and dispositional fate of 1,2-dibromo-2,4-dicyanobutane in the male fischer 344 Rat.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):429-36.
1998: DA Badger; J Kraner; D Fraser; NC Hoglen; James Halpert; I Glenn Sipes
Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol.
Life sciences 1998;63(25):PL367-72.
1997: John-Michael Sauer; J Bao; RL Smith; Robert K Kuester; Michael Mayersohn; I Glenn Sipes
Absorption, disposition, and metabolism of trans-methyl styryl ketone in female B6C3F1 mice.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1184-90.
1997: J Bao; RL Smith; John-Michael Sauer; U Pillai; I Glenn Sipes
Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(1):59-68.
1997: John-Michael Sauer; Michael P Waalkes; Stephen B Hooser; Robert K Kuester; Charlene A McQueen; I Glenn Sipes
Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat.
Toxicology 1997;121(2):155-64.
1997: DA Badger; Robert K Kuester; John-Michael Sauer; I Glenn Sipes
Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity.
Toxicology 1997;121(2):143-53.
1997: NC Hoglen; E A Abril; John-Michael Sauer; D L Earnest; Robert S McCuskey; R Clark Lantz; S A Mobley; I Glenn Sipes
Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol.
Liver 1997;17(3):157-65.
1997: John-Michael Sauer; RL Smith; J Bao; MJ Kattnig; Robert K Kuester; TD McClure; Michael Mayersohn; I Glenn Sipes
Oral and topical absorption, disposition kinetics, and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):732-9.
1997: NC Hoglen; S C Waller; I Glenn Sipes; Daniel C Liebler
Reactions of peroxynitrite with gamma-tocopherol.
Chemical research in toxicology 1997;10(4):401-7.
1997: John-Michael Sauer; J Bao; RL Smith; TD McClure; Michael Mayersohn; U Pillai; M L Cunningham; I Glenn Sipes
Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(3):371-8.
1997: John-Michael Sauer; Michael P Waalkes; Stephen B Hooser; A T Baines; Robert K Kuester; I Glenn Sipes
Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: role of metallothionein expression.
Toxicology and applied pharmacology 1997;143(1):110-9.
1997: John-Michael Sauer; E R Stine; L Gunawardhana; D A Hill; I Glenn Sipes
The liver as a target for chemical-chemical interactions.
Advances in pharmacology (San Diego, Calif.) 1997;43():37-63.
1996: D A Badger; John-Michael Sauer; NC Hoglen; C S Jolley; I Glenn Sipes
The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol.
Toxicology and applied pharmacology 1996;141(2):507-19.
1996: J B Wueweera; A Gandolfi; D A Badger; I Glenn Sipes; Klaus Brendel
Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;34(1):73-83.
1996: J K Doerr; E A Hollis; I Glenn Sipes
Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F1 mice and Sprague-Dawley rats.
Toxicology 1996;113(1-3):128-36.
1996: T L Ziegler; U A Pillai; RL Smith; M J Kattnig; Daniel C Liebler; Michael Mayersohn; I Glenn Sipes
Absorption and disposition kinetics of 3,3',4,4'-tetrachloroazoxybenzene in the male Fischer 344 rat.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(9):1009-14.
1996: L N Springer; J L Tilly; I Glenn Sipes; Patricia B Hoyer
Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat.
Toxicology and applied pharmacology 1996;139(2):402-10.
1996: L N Springer; Mary McAsey; Jodi A Flaws; J L Tilly; I Glenn Sipes; Patricia B Hoyer
Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.
Toxicology and applied pharmacology 1996;139(2):394-401.
1996: L N Springer; Jodi A Flaws; I Glenn Sipes; Patricia B Hoyer
Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.
Reproductive toxicology (Elmsford, N.Y.) 1996;10(2):137-43.
1996: U A Pillai; T L Ziegler; D X Wang; M J Kattnig; TD McClure; Daniel C Liebler; Michael Mayersohn; I Glenn Sipes
3,3',4,4'-tetrachloroazobenzene absorption, disposition, and metabolism in male Fischer 344 rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(2):238-44.
1996: J K Doerr; I Glenn Sipes
Ovarian toxicity and metabolism of 4-vinylcyclohexene and analogues in B6C3F1 mice: structure-activity study of 4-vinylcyclohexene and analogues.
Advances in experimental medicine and biology 1996;387():377-84.
1996: Patricia B Hoyer; I Glenn Sipes
Assessment of follicle destruction in chemical-induced ovarian toxicity.
Annual review of pharmacology and toxicology 1996;36():307-31.
1995: John-Michael Sauer; I Glenn Sipes
Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat.
Toxicology 1995;105(2-3):237-49.
1995: J K Doerr; Stephen B Hooser; B J Smith; I Glenn Sipes
Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides.
Chemical research in toxicology 1995;8(7):963-9.
1995: John-Michael Sauer; Stephen B Hooser; I Glenn Sipes
All-trans-retinol alteration of 1-nitronaphthalene-induced pulmonary and hepatic injury by modulation of associated inflammatory responses in the male Sprague-Dawley rat.
Toxicology and applied pharmacology 1995;133(1):139-49.
1995: Stephen B Hooser; D G DeMerell; D A Douds; P Hoyer; I Glenn Sipes
Testicular germ cell toxicity caused by vinylcyclohexene diepoxide in mice.
Reproductive toxicology (Elmsford, N.Y.) 1995;9(4):359-67.
1995: R J Rosengren; John-Michael Sauer; Stephen B Hooser; I Glenn Sipes
The interactions between retinol and five different hepatotoxicants in the Swiss Webster mouse.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;25(2):281-92.
1995: R L Fisher; S J Hasal; I Glenn Sipes; A Gandolfi; Klaus Brendel
Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices.
Human & experimental toxicology 1995;14(5):414-21.
1995: John-Michael Sauer; Stephen B Hooser; D A Badger; A Baines; I Glenn Sipes
Alterations in chemically induced tissue injury related to all-trans-retinol pretreatment in rodents.
Drug metabolism reviews 1995;27(1-2):299-323.
1995: John-Michael Sauer; I Glenn Sipes
all-trans-retinol modulation of nitronaphthalene-induced lung and liver injury in male Sprague-Dawley rats.
Proceedings of the Western Pharmacology Society 1995;38():29-31.
1994: W Zheng; S M Winter; M J Kattnig; Dean E Carter; I Glenn Sipes
Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide.
Journal of toxicology and environmental health 1994;43(4):483-94.
1994: Jodi A Flaws; J K Doerr; I Glenn Sipes; Patricia B Hoyer
Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide.
Reproductive toxicology (Elmsford, N.Y.) 1994;8(6):509-14.
1994: Stephen B Hooser; R J Rosengren; D A Hill; S A Mobley; I Glenn Sipes
Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents.
Environmental health perspectives 1994;102 Suppl 9():39-43.
1994: Stephen B Hooser; D P Douds; D G DeMerell; Patricia B Hoyer; I Glenn Sipes
Long-term ovarian and gonadotropin changes in mice exposed to 4-vinylcyclohexene.
Reproductive toxicology (Elmsford, N.Y.) 1994;8(4):315-23.
1994: Jodi A Flaws; K L Salyers; I Glenn Sipes; Patricia B Hoyer
Reduced ability of rat preantral ovarian follicles to metabolize 4-vinyl-1-cyclohexene diepoxide in vitro.
Toxicology and applied pharmacology 1994;126(2):286-94.
1994: K L Salyers; J Barr; I Glenn Sipes
In vitro metabolism of theophylline by rat and human liver tissue.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(5):389-99.
1993: W Zheng; S M Winter; Michael Mayersohn; J B Bishop; I Glenn Sipes
Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1091-7.
1993: S M Winter; I Glenn Sipes
The disposition of acrylic acid in the male Sprague-Dawley rat following oral or topical administration.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(9):615-21.
1993: W Zheng; I Glenn Sipes; Dean E Carter
Determination of parts-per-billion concentrations of indium in biological materials by electrothermal atomic absorption spectrometry following ion pair extraction.
Analytical chemistry 1993;65(15):2174-6.
1993: Stephen B Hooser; L R Parola; M D Van Ert; I Glenn Sipes
Differential ovotoxicity of 4-vinylcyclohexene and its analog, 4-phenylcyclohexene.
Toxicology and applied pharmacology 1993;119(2):302-5.
1993: A E elSisi; D L Earnest; I Glenn Sipes
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species.
Toxicology and applied pharmacology 1993;119(2):295-301.
1993: A E elSisi; D L Earnest; I Glenn Sipes
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: enhanced lipid peroxidation without enhanced biotransformation.
Toxicology and applied pharmacology 1993;119(2):289-94.
1993: A E elSisi; P Hall; W L Sim; D L Earnest; I Glenn Sipes
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
Toxicology and applied pharmacology 1993;119(2):280-8.
1993: L Gunawardhana; S A Mobley; I Glenn Sipes
Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells.
Toxicology and applied pharmacology 1993;119(2):205-13.
1993: R L Fisher; A Gandolfi; I Glenn Sipes; Klaus Brendel
Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver.
Drug and chemical toxicology 1993;16(4):321-39.
1993: D R Steup; P Hall; D A McMillan; I Glenn Sipes
Time course of hepatic injury and recovery following coadministration of carbon tetrachloride and trichloroethylene in Fischer-344 rats.
Toxicologic pathology 1993;21(3):327-34.
1993: R C Dart; Daniel C Liebler; I Glenn Sipes
Hepatic injury and lipid peroxidation during hemorrhagic shock and resuscitation.
Life sciences 1993;53(22):1685-90.
1992: S M Winter; G L Weber; P R Gooley; N E MacKenzie; I Glenn Sipes
Identification and comparison of the urinary metabolites of [1,2,3-13C3]acrylic acid and [1,2,3-13C3]propionic acid in the rat by homonuclear 13C nuclear magnetic resonance spectroscopy.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):665-72.
1992: G L Weber; I Glenn Sipes
In vitro metabolism and bioactivation of 1,2,3-trichloropropane.
Toxicology and applied pharmacology 1992;113(1):152-8.
1991: R Fisher; J Barr; C F Zukoski; C W Putnam; I Glenn Sipes; A Gandolfi; Klaus Brendel
In-vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices.
Human & experimental toxicology 1991;10(5):357-63.
1991: E R Stine; L Gunawardhana; I Glenn Sipes
The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity.
Toxicology and applied pharmacology 1991;109(3):472-81.
1991: B J Smith; I Glenn Sipes
Epoxidation of 4-vinylcyclohexene by human hepatic microsomes.
Toxicology and applied pharmacology 1991;109(2):367-71.
1991: S M Wishnies; A R Parrish; I Glenn Sipes; A Gandolfi; C W Putnam; C L Krumdieck; Klaus Brendel
Biotransformation activity in vitrified human liver slices.
Cryobiology 1991;28(3):216-26.
1991: D R Steup; D Wiersma; D A McMillan; I Glenn Sipes
Pretreatment with drinking water solutions containing trichloroethylene or chloroform enhances the hepatotoxicity of carbon tetrachloride in Fischer 344 rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1991;16(4):798-809.
1991: L Gunawardhana; J Barr; A J Weir; Klaus Brendel; I Glenn Sipes
The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):648-54.
1991: J Barr; A J Weir; Klaus Brendel; I Glenn Sipes
Liver slices in dynamic organ culture. II. An in vitro cellular technique for the study of integrated drug metabolism using human tissue.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(3):341-50.
1991: J Barr; A J Weir; Klaus Brendel; I Glenn Sipes
Liver slices in dynamic organ culture. I. An alternative in vitro technique for the study of rat hepatic drug metabolism.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(3):331-9.
1991: G L Weber; I Glenn Sipes
Rat hepatic DNA damage induced by 1,2,3-trichloropropane.
Advances in experimental medicine and biology 1991;283():853-5.
1991: L Gunawardhana; I Glenn Sipes
Dichlorobenzene hepatotoxicity strain differences and structure activity relationships.
Advances in experimental medicine and biology 1991;283():731-4.
1991: R Fisher; S McCarthy; I Glenn Sipes; R P Hanzlik; Klaus Brendel
Metabolism of dichlorobenzenes in organ cultured liver slices.
Advances in experimental medicine and biology 1991;283():717-23.
1991: I Glenn Sipes; A E el Sisi; W W Sim; S A Mobley; D L Earnest
Reactive oxygen species in the progression of CCl4-induced liver injury.
Advances in experimental medicine and biology 1991;283():489-97.
1991: B J Smith; Donald R Mattison; I Glenn Sipes
Hepatic bioactivation of 4-vinylcyclohexene to ovotoxic epoxides.
Advances in experimental medicine and biology 1991;283():465-70.
1991: B J Smith; David Plowchalk; I Glenn Sipes; Donald R Mattison
Comparison of random and serial sections in assessment of ovarian toxicity.
Reproductive toxicology (Elmsford, N.Y.) 1991;5(4):379-83.
1991: S I Mufti; I Glenn Sipes
A reduction in mixed function oxidases and in tumor promoting effects of ethanol in a NDEA-initiated hepatocarcinogenesis model.
Advances in experimental medicine and biology 1991;283():347-52.
1990: B J Smith; I Glenn Sipes; JC Stevens; James Halpert
The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats.
Carcinogenesis 1990;11(11):1951-7.
1990: B J Smith; Donald R Mattison; I Glenn Sipes
The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity.
Toxicology and applied pharmacology 1990;105(3):372-81.
1990: B J Smith; Dean E Carter; I Glenn Sipes
Comparison of the disposition and in vitro metabolism of 4-vinylcyclohexene in the female mouse and rat.
Toxicology and applied pharmacology 1990;105(3):364-71.
1990: G L Weber; I Glenn Sipes
Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: studies in the male F-344 rat.
Toxicology and applied pharmacology 1990;104(3):395-402.
1989: S I Mufti; G Becker; I Glenn Sipes
Effect of chronic dietary ethanol consumption on the initiation and promotion of chemically-induced esophageal carcinogenesis in experimental rats.
Carcinogenesis 1989;10(2):303-9.
1989: A E Elsisi; Dean E Carter; I Glenn Sipes
Dermal absorption of phthalate diesters in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1989;12(1):70-7.
1988: D B Duignan; I Glenn Sipes; P J Ciaccio; James Halpert
The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2.
Archives of biochemistry and biophysics 1988;267(1):294-304.
1988: L Gunawardhana; J Barr; A J Weir; Klaus Brendel; I Glenn Sipes
Liver slices: an in vitro system for determination of N-acetylation in human liver.
Proceedings of the Western Pharmacology Society 1988;31():137-41.
1987: D B Duignan; I Glenn Sipes; T B Leonard; James Halpert
Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
Archives of biochemistry and biophysics 1987;255(2):290-303.
1986: D A Wiersma; Rick G Schnellmann; I Glenn Sipes
The in vitro metabolism and bioactivation of 1,2-dibromoethane (ethylene dibromide) by human liver.
Journal of biochemical toxicology 1986;1(3):1-11.
1984: Rick G Schnellmann; D A Wiersma; D J Randall; T L Smith; I Glenn Sipes
Hepatic mixed function oxygenase activity and glutathione S-transferase activity in mice following ethanol consumption and withdrawal.
Toxicology 1984;32(2):105-16.