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Karin Sipido

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Karin R Sipido; Heping Cheng
T-tubules and ryanodine receptor microdomains: on the road to translation.
Ilse Lenaerts; Karin R Sipido; Jean-Luc Balligand; Nerea Hermida Blanco; Ronald B Driesen; Hein Heidbüchel; Patricia Holemans; Stefan Janssens; Rik Willems
Role of nitric oxide and oxidative stress in a sheep model of persistent atrial fibrillation.
Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.

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2013: Karin R Sipido; Heping Cheng
T-tubules and ryanodine receptor microdomains: on the road to translation.
Cardiovascular research 2013;98(2):159-61.
2013: Ilse Lenaerts; Karin R Sipido; Jean-Luc Balligand; Nerea Hermida Blanco; Ronald B Driesen; Hein Heidbüchel; Patricia Holemans; Stefan Janssens; Rik Willems
Role of nitric oxide and oxidative stress in a sheep model of persistent atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2013;15(5):754-60.
2013: Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
Circulation. Arrhythmia and electrophysiology 2013;6(2):371-9.
2013: Karin R Sipido; Károly Acsai; Gudrun Antoons; Virginie Bito; Niall Macquaide
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Advances in experimental medicine and biology 2013;961():375-83.
2013: Nan Wang; Joris Wauman; Kerstin Boengler; Mélissa Bol; Feliksas F Bukauskas; Geert Bultynck; Manuelle De Bock; Elke De Vuyst; Elke Decrock; W Howard Evans; Gerd Heusch; Charles P Lai; Christian C Naus; Nicolás Palacios-Prado; Raf Ponsaerts; Vera Rogiers; Rainer Schulz; Karin R Sipido; Jan Tavernier; Mathieu Vinken; Luc Leybaert
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
Basic research in cardiology 2013;108(1):309.
2013: Karin R Sipido
What does the future hold for Cardiovascular Research?
Cardiovascular research 2013;97(1):1-3.
2013: Virginie Bito; Barnabas Gellen; Niall Macquaide; Jean-Jacques Mercadier; Mylène Pezet; Patricia Rouet-Benzineb; Gudrun Antoons; Liesbeth Biesmans; Karin R Sipido
FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.
Experimental physiology 2013;98(1):134-48.
2012: Vincent J A Bourgonje; Leon J De Windt; Marien J C Houtman; Lars F Miedema; Marieke Schoenmakers; Karin R Sipido; Roel van der Nagel; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Marc A Vos
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(11):1875-83.
2012: Karin R Sipido; Frans Van de Werf
The growing burden of cardiovascular disease.
European heart journal 2012;33(13):1540-1.
2012: William E Louch; Luc Raeymaekers; Peter Vangheluwe; Frank Wuytack; Virginie Bito; Karin R Sipido
Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling.
American journal of physiology. Heart and circulatory physiology 2012;302(12):H2574-82.
2012: Marc A Vos; Karin R Sipido
Impairment of trafficking by downregulation of an anchor protein: novel insights into additional mechanisms responsible for heart failure.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(5):821-2.
2012: Ronald B Driesen; Karin R Sipido; Frans Van de Werf; Kristel Vermeulen; Jaroslaw Zalewski; Nina Vanden Driessche; Jan Bogaert; Piet Claus
Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2012;21(3):129-31.
2012: Gudrun Antoons; Rik Willems; Karin R Sipido
Alternative strategies in arrhythmia therapy: evaluation of Na/Ca exchange as an anti-arrhythmic target.
Pharmacology & therapeutics 2012;134(1):26-42.
2012: Laurent Vinet; Liesbeth Biesmans; Virginie Bito; François Briec; Flavien Charpentier; Stefano Chimenti; Barnabas Gellen; Mylène Pezet; Miresta Prévilon; Patricia Rouet-Benzineb; Karin R Sipido; Jean-Paul Vilaine; Jean-Jacques Mercadier
Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts.
Basic research in cardiology 2012;107(2):246.
2012: Georgios Kararigas; Christoph Knosalla; Karin R Sipido; Hanna Tinel; Barbara Albrecht-Küpper; Istvan Baczko; Eva Becher; Virginie Bito; Vera Regitz-Zagrosek
Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function.
Journal of the American College of Cardiology 2012;59(4):410-7.
2012: Nan Wang; Karin R Sipido; Gudrun Antoons; Mélissa Bol; Feliksas F Bukauskas; Manuelle De Bock; Elke Decrock; William Howard Evans; Ashish K Gadicherla; Luc Leybaert
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation.
Basic research in cardiology 2012;107(6):304.
2011: María Naranjo; Karin R Sipido; Nicolas Sirtaine; Jean Veys; Jacques Waegenaere; Nadine Botteldoorn; Laurence Delbrassinne; Sarah Denayer; Ronald B Driesen; Jacques Mahillon; Katlijne Dierick
Sudden death of a young adult associated with Bacillus cereus food poisoning.
Journal of clinical microbiology 2011;49(12):4379-81.
2011: Vincent Floré; Patricia Holemans; Peter Oosterhoff; Karin R Sipido; Marc A Vos; Gudrun Antoons; Piet Claus; Rik Willems
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(7):1050-7.
2011: Elza D van Deel; Martine de Boer; Diederik W Kuster; Nicky M Boontje; Patricia Holemans; Karin R Sipido; Jolanda van der Velden; Dirk J Duncker
Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis.
Journal of molecular and cellular cardiology 2011;50(6):1017-25.
2011: Elke De Vuyst; Kerstin Boengler; Gudrun Antoons; Karin R Sipido; Rainer Schulz; Luc Leybaert
Pharmacological modulation of connexin-formed channels in cardiac pathophysiology.
British journal of pharmacology 2011;163(3):469-83.
2011: Karoly Acsai; Gudrun Antoons; Leonid Livshitz; Yoram Rudy; Karin R Sipido
Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.
The Journal of physiology 2011;589(Pt 10):2569-83.
2011: Ilse Lenaerts; Patricia Holemans; Peter Pokreisz; Karin R Sipido; Stefan Janssens; Hein Heidbüchel; Rik Willems
Nitric oxide delays atrial tachycardia-induced electrical remodelling in a sheep model.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2011;13(5):747-54.
2011: Niall Macquaide; Karin R Sipido
Blink and you'll see it: how to detect Ca2+ quarks.
Circulation research 2011;108(2):154-6.
2011: Liesbeth Biesmans; Virginie Bito; Frank R Heinzel; Niall Macquaide; Godfrey L Smith; Karin R Sipido
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
PloS one 2011;6(10):e25100.
2011: Ming Wu; Jan D'Hooge; Javier Ganame; Vesselina Ferferieva; Karin R Sipido; Frederik Maes; Steven Dymarkowski; Jan Bogaert; Frank E Rademakers; Piet Claus
Non-invasive characterization of the area-at-risk using magnetic resonance imaging in chronic ischaemia.
Cardiovascular research 2011;89(1):166-74.
2010: Asfree Gwanyanya; Regina Macianskiene; Virginie Bito; Karin R Sipido; Johan Vereecke; Kanigula Mubagwa
Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA).
Biochemical and biophysical research communications 2010;402(3):531-6.
2010: Regina Macianskiene; Asfree Gwanyanya; Karin R Sipido; Johan Vereecke; Kanigula Mubagwa
Induction of a novel cation current in cardiac ventricular myocytes by flufenamic acid and related drugs.
British journal of pharmacology 2010;161(2):416-29.
2010: Virginie Bito; Monique C de Waard; Liesbeth Biesmans; Ilse Lenaerts; Semir Ozdemir; Elza van Deel; Yousra Abdel-Mottaleb; Ronald Driesen; Patricia Holemans; Dirk J Duncker; Karin R Sipido
Early exercise training after myocardial infarction prevents contractile but not electrical remodelling or hypertrophy.
Cardiovascular research 2010;86(1):72-81.
2010: Karin R Sipido; Peter Vangheluwe
Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.
Circulation research 2010;106(2):230-3.
2009: Ilse Lenaerts; Virginie Bito; Frank R Heinzel; Ronald B Driesen; Patricia Holemans; Jan D'hooge; Hein Heidbüchel; Karin R Sipido; Rik Willems
Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation.
Circulation research 2009;105(9):876-85.
2009: Karin R Sipido; Alain Tedgui; Steen D Kristensen; Gerard Pasterkamp; Heribert Schunkert; Martin Wehling; Philippe Gabriel STEG; Wolfgang Eisert; Frank Rademakers; Barbara Casadei; Valentin Fuster; Elisabetta Cerbai; Gerd Hasenfuss; Francisco Fernandez-Aviles; David Garcia-Dorado; Maria Vidal; Manuel Hallen; Virginija Dambrauskaite
Identifying needs and opportunities for advancing translational research in cardiovascular disease.
Cardiovascular research 2009;83(3):425-35.
2009: Gudrun Antoons; Karin R Sipido
Dofetilide as activator of Na/Ca exchange: new perspectives on an 'old' drug. Editorial to: "Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange" by Xuan-Ping Zhang et al.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2009;23(3):189-92.
2008: Gudrun Antoons; Karin R Sipido
Targeting calcium handling in arrhythmias.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2008;10(12):1364-9.
2008: Semir Ozdemir; Virginie Bito; Patricia Holemans; Laurent Vinet; Jean-Jacques Mercadier; Andras Varro; Karin R Sipido
Pharmacological inhibition of na/ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block.
Circulation research 2008;102(11):1398-405.
2008: Frank R Heinzel; Virginie Bito; Liesbeth Biesmans; Ming Wu; Elke Detre; Frederik von Wegner; Piet Claus; Steven Dymarkowski; Frederik Maes; Jan Bogaert; Frank Rademakers; Jan D'Hooge; Karin R Sipido
Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium.
Circulation research 2008;102(3):338-46.
2008: Virginie Bito; Frank R Heinzel; Liesbeth Biesmans; Gudrun Antoons; Karin R Sipido
Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling.
Cardiovascular research 2008;77(2):315-24.
2007: Steen Dalby Kristensen; Helmut Baumgartner; Helmut Drexler; Eric Eeckhout; Gerasimos Filippatos; Anselm Gitt; Cecilia Linde; Luc A Pierard; Don Poldermans; Heribert Schunkert; Karin R Sipido; Ernst E van der Wall; Kim Fox; Jeroen J Bax
Highlights of the 2007 scientific sessions of the European Society of Cardiology Vienna, Austria, September 1-5, 2007.
Journal of the American College of Cardiology 2007;50(25):2421-30.
2007: Piet Claus; Frank Weidemann; Christoph Dommke; Virginie Bito; Frank R Heinzel; Jan D'Hooge; Karin R Sipido; George R Sutherland; Bart Bijnens
Mechanisms of postsystolic thickening in ischemic myocardium: mathematical modelling and comparison with experimental ischemic substrates.
Ultrasound in medicine & biology 2007;33(12):1963-70.
2007: Gudrun Antoons; Avram Oros; Virginie Bito; Karin R Sipido; Marc A Vos
Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment.
Journal of electrocardiology 2007;40(6 Suppl):S8-14.
2007: Karin R Sipido; Stefan P Janssens
How old is your heart?
Circulation research 2007;101(4):323-5.
2007: Lieve Umans; Luk Cox; Marc Tjwa; Virginie Bito; Liesbeth Vermeire; Kjell Laperre; Karin R Sipido; Lieve Moons; Danny Huylebroeck; An Zwijsen
Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis.
The American journal of pathology 2007;170(5):1460-72.
2007: Monique C de Waard; Dirk Duncker; Virginie Bito; Semir Ozdemir; Liesbeth Biesmans; Nicky M Boontje; Dick H W Dekkers; Kees Schoonderwoerd; Hans C H Schuurbiers; Rini de Crom; Ger J M Stienen; Karin R Sipido; Jos M J Lamers; Dirk J Duncker
Early exercise training normalizes myofilament function and attenuates left ventricular pump dysfunction in mice with a large myocardial infarction.
Circulation research 2007;100(7):1079-88.
2007: Karin R Sipido; Virginie Bito; Gudrun Antoons; Paul G A Volders; Marc A Vos
Na/Ca exchange and cardiac ventricular arrhythmias.
Annals of the New York Academy of Sciences 2007;1099():339-48.
2007: Karin R Sipido
CaM or cAMP: linking beta-adrenergic stimulation to 'leaky' RyRs.
Circulation research 2007;100(3):296-8.
2007: Gudrun Antoons; Paul G A Volders; Tania Stankovicova; Virginie Bito; Milan Stengl; Marc A Vos; Karin R Sipido
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
The Journal of physiology 2007;579(Pt 1):147-60.
2007: Virginie Bito; Jolanda van der Velden; Piet Claus; Christoph Dommke; Alfons Van Lommel; Luc Mortelmans; Erik Verbeken; Bart Bijnens; Ger J M Stienen; Karin R Sipido
Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium.
Circulation research 2007;100(2):229-37.
2006: Jeroen J Bax; Bernard De Bruyne; Anselm Gitt; Steen Kristensen; Cecilia Linde; Don Poldermans; Fausto J Pinto; Piotr Ponikowski; Bernard D Prendergast; Enrico Abagiti-Rosei; Sidney C Smith; Karin R Sipido; Ernst E van der Wall; Michal Tendera; Michel Komajda
Highlights of the 2006 scientific sessions of the European Society of Cardiology: Barcelona, Spain, September 2-5, 2006.
Journal of the American College of Cardiology 2006;48(12):2564-74.
2006: Peter Vangheluwe; Karin R Sipido; Luc Raeymaekers; Frank Wuytack
New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.
Biochimica et biophysica acta 2006;1763(11):1216-28.
2006: Milan Stengl; Christian Ramakers; Dirk W Donker; Ashish Nabar; Andrew V Rybin; Roel L H M G Spätjens; Theo Van Der Nagel; Will K W H Wodzig; Karin R Sipido; Gudrun Antoons; Antoon F M Moorman; Marc A Vos; Paul G A Volders
Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.
Cardiovascular research 2006;72(1):90-100.
2006: Asfree Gwanyanya; Karin R Sipido; Johan Vereecke; Kanigula Mubagwa
ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes.
American journal of physiology. Cell physiology 2006;291(4):C627-35.
2006: Karin R Sipido
Calcium overload, spontaneous calcium release, and ventricular arrhythmias.
Heart rhythm : the official journal of the Heart Rhythm Society 2006;3(8):977-9.
2006: Peter Vangheluwe; Marc Tjwa; An Van den Bergh; William E Louch; Monique Beullens; Leonard Dode; Peter Carmeliet; Evangelia G Kranias; Paul Herijgers; Karin R Sipido; Luc Raeymaekers; Frank Wuytack
A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.
Journal of molecular and cellular cardiology 2006;41(2):308-17.
2006: Gudrun Antoons; Peter Vangheluwe; Paul G A Volders; Virginie Bito; Patricia Holemans; Marcello Ceci; Frank Wuytack; Pico Caroni; Kanigula Mubagwa; Karin R Sipido
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Journal of molecular and cellular cardiology 2006;40(3):350-60.
2006: Karin R Sipido; A Varro; D Eisner
Sodium calcium exchange as a target for antiarrhythmic therapy.
Handbook of experimental pharmacology 2006;(171):159-99.
2006: Virginie Bito; Dieter Dauwe; Fons Verdonck; Kanigula Mubagwa; Karin R Sipido
The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytes.
The Journal of pharmacology and experimental therapeutics 2006;316(1):162-8.
2005: Karin R Sipido; David Eisner
Something old, something new: changing views on the cellular mechanisms of heart failure.
Cardiovascular research 2005;68(2):167-74.
2005: Virginie Bito; Frank R Heinzel; Piet Claus; Bart Bijnens; Erik Verbeken; Jolanda Van der Velden; Ger Stienen; Karin R Sipido
Alterations in excitation-contraction coupling in chronically ischemic or hibernating myocardium.
Experimental and clinical cardiology 2005;10(3):142-5.
2004: David A Eisner; Karin R Sipido
Sodium calcium exchange in the heart: necessity or luxury?
Circulation research 2004;95(6):549-51.
2004: Asfree Gwanyanya; Bogdan Amuzescu; Sergey I Zakharov; Regina Macianskiene; Karin R Sipido; Victoria M Bolotina; Johan Vereecke; Kanigula Mubagwa
Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation.
The Journal of physiology 2004;559(Pt 3):761-76.
2004: Fons Verdonck; Kanigula Mubagwa; Karin R Sipido
[Na(+)] in the subsarcolemmal 'fuzzy' space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes.
Cell calcium 2004;35(6):603-12.
2004: Gerd Heusch; Karin R Sipido
Myocardial hibernation: a double-edged sword.
Circulation research 2004;94(8):1005-7.
2004: Virginie Bito; Frank R Heinzel; Frank Weidemann; Christoph Dommke; Jolanda van der Velden; Erik Verbeken; Piet Claus; Bart Bijnens; Ivan De Scheerder; Ger J M Stienen; George R Sutherland; Karin R Sipido
Cellular mechanisms of contractile dysfunction in hibernating myocardium.
Circulation research 2004;94(6):794-801.
2004: Rik Willems; Karin R Sipido
Nonexcitatory stimulation as a novel treatment for heart failure: cause for excitement?
European heart journal 2004;25(8):626-8.
2004: William E Louch; Virginie Bito; Frank R Heinzel; Regina Macianskiene; Johan Vanhaecke; Willem Flameng; Kanigula Mubagwa; Karin R Sipido
Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes.
Cardiovascular research 2004;62(1):63-73.
2004: Karin R Sipido
Understanding cardiac alternans: the answer lies in the Ca2+ store.
Circulation research 2004;94(5):570-2.
2004: Otto A Smiseth; Philippe Gabriel STEG; Karin R Sipido; Alexander Battler
News from the European Society of Cardiology congress in Vienna, August 30 to September 3, 2003.
Journal of the American College of Cardiology 2004;43(4):691-7.
2003: Peter Vangheluwe; William E Louch; Mark Ver Heyen; Karin R Sipido; Luc Raeymaekers; Frank Wuytack
Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart.
Cell calcium 2003;34(6):457-64.
2003: Milan Stengl; Paul G A Volders; Morten B Thomsen; Roel L H M G Spätjens; Karin R Sipido; Marc A Vos
Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.
The Journal of physiology 2003;551(Pt 3):777-86.
2003: T Stankovicová; Virginie Bito; Frank R Heinzel; Kanigula Mubagwa; Karin R Sipido
Isolation and morphology of single Purkinje cells from the porcine heart.
General physiology and biophysics 2003;22(3):329-40.
2003: Regina Macianskiene; Virginie Bito; Luc Raeymaekers; Bodo Brandts; Karin R Sipido; Kanigula Mubagwa
Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015.
British journal of pharmacology 2003;139(8):1469-79.
2003: Paul G A Volders; Milan Stengl; Jurren M van Opstal; Uwe Gerlach; Roel L H M G Spätjens; Jet D M Beekman; Karin R Sipido; Marc A Vos
Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.
Circulation 2003;107(21):2753-60.
2003: Gudrun Antoons; Mark Ver Heyen; Luc Raeymaekers; Peter Vangheluwe; Frank Wuytack; Karin R Sipido
Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only.
Circulation research 2003;92(8):881-7.
2003: Fons Verdonck; Paul G A Volders; Marc A Vos; Karin R Sipido
Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells.
Cardiovascular research 2003;57(4):1035-43.
2003: Steven M Pogwizd; Karin R Sipido; Fons Verdonck; Donald M Bers
Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis.
Cardiovascular research 2003;57(4):887-96.
2003: Karin R Sipido
Triggering controversy in cardiac excitation-contraction coupling.
Journal of molecular and cellular cardiology 2003;35(2):133-5.
2003: Fons Verdonck; Paul G A Volders; Marc A Vos; Karin R Sipido
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.
Journal of molecular and cellular cardiology 2003;35(1):5-25.
2003: Regina Macianskiene; S Viappiani; Karin R Sipido; Kanigula Mubagwa
Slowing of the inactivation of cardiac voltage-dependent sodium channels by the amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015).
The Journal of pharmacology and experimental therapeutics 2003;304(1):130-8.
2002: Frank R Heinzel; Virginie Bito; Paul G A Volders; Gudrun Antoons; Kanigula Mubagwa; Karin R Sipido
Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes.
Circulation research 2002;91(11):1023-30.
2002: Karin R Sipido; Paul G A Volders; Marieke Schoenmakers; S H Marieke De Groot; Fons Verdonck; Marc A Vos
Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophy.
Annals of the New York Academy of Sciences 2002;976():438-45.
2002: Gudrun Antoons; Kanigula Mubagwa; Ines Nevelsteen; Karin R Sipido
Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes.
The Journal of physiology 2002;543(Pt 3):889-98.
2002: Regina Macianskiene; Francesco Moccia; Karin R Sipido; Willem Flameng; Kanigula Mubagwa
Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells.
American journal of physiology. Heart and circulatory physiology 2002;282(5):H1879-88.
2002: Karin R Sipido; Paul G A Volders; Marc A Vos; Fons Verdonck
Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?
Cardiovascular research 2002;53(4):782-805.
2002: Rik Willems; Patricia Holemans; Hugo Ector; Karin R Sipido; Frans Van de Werf; Hein Heidbüchel
Mind the model: effect of instrumentation on inducibility of atrial fibrillation in a sheep model.
Journal of cardiovascular electrophysiology 2002;13(1):62-7.
2001: Rik Willems; Karin R Sipido; Patricia Holemans; Hugo Ector; Frans Van de Werf; Hein Heidbüchel
Different patterns of angiotensin II and atrial natriuretic peptide secretion in a sheep model of atrial fibrillation.
Journal of cardiovascular electrophysiology 2001;12(12):1387-92.
2001: Mark Ver Heyen; Stephane Heymans; Gudrun Antoons; T Reed; Muthu Periasamy; Bonaventure L Awede; Jean Lebacq; Peter Vangheluwe; Mieke Dewerchin; Désiré Collen; Karin R Sipido; Peter Carmeliet; Frank Wuytack
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circulation research 2001;89(9):838-46.
2001: M J Hernandez-Benito; Regina Macianskiene; Karin R Sipido; Willem Flameng; Kanigula Mubagwa
Suppression of transient outward potassium currents in mouse ventricular myocytes by imidazole antimycotics and by glybenclamide.
The Journal of pharmacology and experimental therapeutics 2001;298(2):598-606.
2001: Regina Macianskiene; P Matejovic; Karin R Sipido; Willem Flameng; Kanigula Mubagwa
Modulation of the extracellular divalent cation-inhibited non-selective conductance in cardiac cells by metabolic inhibition and by oxidants.
Journal of molecular and cellular cardiology 2001;33(7):1371-85.
2000: Karin R Sipido; Paul G A Volders; S H Marieke De Groot; Fons Verdonck; Frans Van de Werf; Hein J J Wellens; Marc A Vos
Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis.
Circulation 2000;102(17):2137-44.
2000: Paul G A Volders; Marc A Vos; B Szabo; Karin R Sipido; S H Marieke De Groot; Anton P Gorgels; Hein J J Wellens; R Lazzara
Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts.
Cardiovascular research 2000;46(3):376-92.
2000: Tania Stankovicova; M Szilard; Ivan De Scheerder; Karin R Sipido
M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart.
Cardiovascular research 2000;45(4):952-60.
1999: Paul G A Volders; Karin R Sipido; Marc A Vos; Roel L H M G Spätjens; Jet D M Leunissen; Edward Carmeliet; Hein J J Wellens
Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.
Circulation 1999;100(24):2455-61.
1999: Paul G A Volders; Karin R Sipido; Edward Carmeliet; Roel L H M G Spätjens; Hein J J Wellens; Marc A Vos
Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium.
Circulation 1999;99(2):206-10.
1998: Karin R Sipido
Efficiency of L-type Ca2+ current compared to reverse mode Na/Ca exchange or T-type Ca2+ current as trigger for Ca2+ release from the sarcoplasmic reticulum.
Annals of the New York Academy of Sciences 1998;853():357-60.
1998: Karin R Sipido; Tania Stankovicova; Johan Vanhaecke; Willem Flameng; Fons Verdonck
A critical role for L-type Ca2+ current in the regulation of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from dilated cardiomyopathy.
Annals of the New York Academy of Sciences 1998;853():353-6.
1998: Paul G A Volders; Karin R Sipido; Marc A Vos; A Kulcsár; S Cora Verduyn; Hein J J Wellens
Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes.
Circulation 1998;98(11):1136-47.
1998: Karin R Sipido; Edward Carmeliet; Frans Van de Werf
T-type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes.
The Journal of physiology 1998;508 ( Pt 2)():439-51.
1998: Karin R Sipido; Tania Stankovicova; Willem Flameng; Johan Vanhaecke; Fons Verdonck
Frequency dependence of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from end-stage heart failure.
Cardiovascular research 1998;37(2):478-88.
1997: Karin R Sipido; M Maes; Frans Van de Werf
Low efficiency of Ca2+ entry through the Na(+)-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum. A comparison between L-type Ca2+ current and reverse-mode Na(+)-Ca2+ exchange.
Circulation research 1997;81(6):1034-44.
1997: Paul G A Volders; A Kulcśar; Marc A Vos; Karin R Sipido; H J Wellens; Ralph Lazzara; B Szabo
Similarities between early and delayed afterdepolarizations induced by isoproterenol in canine ventricular myocytes.
Cardiovascular research 1997;34(2):348-59.
1997: Kanigula Mubagwa; W Lin; Karin R Sipido; S Bosteels; Willem Flameng
Monensin-induced reversal of positive force-frequency relationship in cardiac muscle: role of intracellular sodium in rest-dependent potentiation of contraction.
Journal of molecular and cellular cardiology 1997;29(3):977-89.
1995: Karin R Sipido; Edward Carmeliet; A Pappano
Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes.
The Journal of physiology 1995;489 ( Pt 1)():1-17.
1995: Karin R Sipido; Geert Callewaert; F Porciatti; J Vereecke; Edward Carmeliet
[Ca2+]i-dependent membrane currents in guinea-pig ventricular cells in the absence of Na/Ca exchange.
Pflügers Archiv : European journal of physiology 1995;430(5):871-8.
1995: Karin R Sipido; Geert Callewaert
How to measure intracellular [Ca2+] in single cardiac cells with fura-2 or indo-1.
Cardiovascular research 1995;29(5):717-26.
1995: Geert Callewaert; Karin R Sipido; Edward Carmeliet; Lutz Pott; Peter Lipp
Intracellular citrate induces regenerative calcium release from sarcoplasmic reticulum in guinea-pig atrial myocytes.
Pflügers Archiv : European journal of physiology 1995;429(6):797-804.
1995: Z Papp; Karin R Sipido; Geert Callewaert; Edward Carmeliet
Two components of [Ca2+]i-activated Cl- current during large [Ca2+]i transients in single rabbit heart Purkinje cells.
The Journal of physiology 1995;483 ( Pt 2)():319-30.
1995: Karin R Sipido; Geert Callewaert; Edward Carmeliet
Inhibition and rapid recovery of Ca2+ current during Ca2+ release from sarcoplasmic reticulum in guinea pig ventricular myocytes.
Circulation research 1995;76(1):102-9.
1993: Karin R Sipido; Geert Callewaert; Edward Carmeliet
[Ca2+]i transients and [Ca2+]i-dependent chloride current in single Purkinje cells from rabbit heart.
The Journal of physiology 1993;468():641-67.