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Alphonse Sirica

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TOP 3
Alphonse E Sirica
Notching up on the cellular origins of intrahepatic cholangiocarcinoma.
Joachim C Mertens; Lewis R Roberts; Alphonse E Sirica; Rory L Smoot; Nathan W Werneburg; Steven F Bronk; John D Christensen; Allan B Dietz; Christian D Fingas; Michael P Gustafson; Gregory J Gores
Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma.
Deanna J W Campbell; Jennifer L Dewitt; Catherine I Dumur; Nadia F Lamour; Alphonse E Sirica
Novel organotypic culture model of cholangiocarcinoma progression.

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All Publications

2013: Alphonse E Sirica
Notching up on the cellular origins of intrahepatic cholangiocarcinoma.
Hepatology (Baltimore, Md.) 2013;57(4):1668-71.
2013: Joachim C Mertens; Lewis R Roberts; Alphonse E Sirica; Rory L Smoot; Nathan W Werneburg; Steven F Bronk; John D Christensen; Allan B Dietz; Christian D Fingas; Michael P Gustafson; Gregory J Gores
Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma.
Cancer research 2013;73(2):897-907.
2012: Deanna J W Campbell; Jennifer L Dewitt; Catherine I Dumur; Nadia F Lamour; Alphonse E Sirica
Novel organotypic culture model of cholangiocarcinoma progression.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(11):1119-30.
2012: Christian Dominik Fingas; Joachim C Mertens; Nataliya Razumilava; Alphonse E Sirica; Steven F Bronk; Gregory J Gores
Targeting PDGFR-β in Cholangiocarcinoma.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(3):400-9.
2011: Christian D Fingas; Steven F Bronk; Sophie C Cazanave; Maria Eugenia Guicciardi; Joachim C Mertens; Justin L Mott; Alphonse E Sirica; Nathan W Werneburg; Gregory J Gores
Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells.
Hepatology (Baltimore, Md.) 2011;54(6):2076-88.
2011: Alphonse E Sirica; Deanna J Campbell; Catherine I Dumur
Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma.
Current opinion in gastroenterology 2011;27(3):276-84.
2010: Catherine I Dumur; Deanna J W Campbell; Jennifer L DeWitt; Regina A Oyesanya; Alphonse E Sirica
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
Experimental and molecular pathology 2010;89(3):227-35.
2010: Zichen Zhang; Regina A Oyesanya; Deanna J W Campbell; Jorge A Almenara; Jennifer L Dewitt; Alphonse E Sirica
Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy.
Hepatology (Baltimore, Md.) 2010;52(3):975-86.
2010: Christian D Fingas; Boris R A Blechacz; Rory L Smoot; Maria Eugenia Guicciardi; Justin Mott; Steven F Bronk; Nathan W Werneburg; Alphonse E Sirica; Gregory J Gores
A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells.
Hepatology (Baltimore, Md.) 2010;52(2):550-61.
2010: Rory L Smoot; Boris R A Blechacz; Nathan W Werneburg; Steven F Bronk; Frank A Sinicrope; Alphonse E Sirica; Gregory J Gores
A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells.
Cancer research 2010;70(5):1960-9.
2009: Boris R A Blechacz; Rory L Smoot; Steven F Bronk; Nathan W Werneburg; Alphonse E Sirica; Gregory J Gores
Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
Hepatology (Baltimore, Md.) 2009;50(6):1861-70.
2009: Alphonse E Sirica; Catherine I Dumur; Deanna J W Campbell; Jorge A Almenara; Olorunseun O Ogunwobi; Jennifer L Dewitt
Intrahepatic cholangiocarcinoma progression: prognostic factors and basic mechanisms.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(11 Suppl):S68-78.
2008: Alphonse E Sirica; Michael H Nathanson; Gregory J Gores; Nicholas F LaRusso
Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference.
Hepatology (Baltimore, Md.) 2008;48(6):2040-6.
2008: Alphonse E Sirica; Zichen Zhang; Guan-Hua Lai; Toru Asano; Xue-Ning Shen; Deanna J Ward; Arvind Mahatme; Jennifer L Dewitt
A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines.
Hepatology (Baltimore, Md.) 2008;47(4):1178-90.
2005: Guan-Hua Lai; Zichen Zhang; Xue-Ning Shen; Deanna J Ward; Jennifer L Dewitt; Shawn E Holt; Rebecca A Rozich; Douglas C Hixson; Alphonse E Sirica
erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.
Gastroenterology 2005;129(6):2047-57.
2005: Alphonse E Sirica
Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy.
Hepatology (Baltimore, Md.) 2005;41(1):5-15.
2004: Zichen Zhang; Guan-Hua Lai; Alphonse E Sirica
Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation.
Hepatology (Baltimore, Md.) 2004;39(4):1028-37.
2003: Guan-Hua Lai; Zichen Zhang; Alphonse E Sirica
Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3.
Molecular cancer therapeutics 2003;2(3):265-71.
2002: Alphonse E Sirica; Guan-Hua Lai; Kanenori Endo; Zichen Zhang; Byung-Il Yoon
Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets.
Seminars in liver disease 2002;22(3):303-13.
2002: Kanenori Endo; Byung-Il Yoon; Chawalit Pairojkul; Anthony J Demetris; Alphonse E Sirica
ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions.
Hepatology (Baltimore, Md.) 2002;36(2):439-50.
2002: Alphonse E Sirica
Bile duct epithelial cell culture.
Methods in molecular biology (Clifton, N.J.) 2002;188():37-52.
2001: Alphonse E Sirica; Guan-Hua Lai; Zichen Zhang
Biliary cancer growth factor pathways, cyclo-oxygenase-2 and potential therapeutic strategies.
Journal of gastroenterology and hepatology 2001;16(4):363-72.
2000: Guan-Hua Lai; S Radaeva; T Nakamura; Alphonse E Sirica
Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated "intestinal-type" biliary cancer chemically induced in rat liver.
Hepatology (Baltimore, Md.) 2000;31(6):1257-65.
2000: P Ren; D G Silberg; Alphonse E Sirica
Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver.
The American journal of pathology 2000;156(2):621-7.
1999: Guan-Hua Lai; Alphonse E Sirica
Establishment of a novel rat cholangiocarcinoma cell culture model.
Carcinogenesis 1999;20(12):2335-40.
1999: S Radaeva; Andrea Ferreira-Gonzalez; Alphonse E Sirica
Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma.
Hepatology (Baltimore, Md.) 1999;29(5):1453-62.
1998: T Terada; Y Nakanuma; Alphonse E Sirica
Immunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis.
Human pathology 1998;29(2):175-80.
1997: Alphonse E Sirica; S Radaeva; Barat Nicole
NEU overexpression in the furan rat model of cholangiocarcinogenesis compared with biliary ductal cell hyperplasia.
The American journal of pathology 1997;151(6):1685-94.
1997: Alphonse E Sirica; T W Gainey
A new rat bile ductular epithelial cell culture model characterized by the appearance of polarized bile ducts in vitro.
Hepatology (Baltimore, Md.) 1997;26(3):537-49.
1997: Alphonse E Sirica
Immortalizing hepatocytes with truncated MET: a little bit of gene goes a long way.
Hepatology (Baltimore, Md.) 1997;26(2):510-2.
1996: Alphonse E Sirica
Biliary proliferation and adaptation in furan-induced rat liver injury and carcinogenesis.
Toxicologic pathology 1996;24(1):90-9.
1995: Alphonse E Sirica
Ductular hepatocytes.
Histology and histopathology 1995;10(2):433-56.
1994: Alphonse E Sirica; T W Gainey; V R Mumaw
Ductular hepatocytes. Evidence for a bile ductular cell origin in furan-treated rats.
The American journal of pathology 1994;145(2):375-83.
1994: Alphonse E Sirica; S L Cole; T Williams
A unique rat model of bile ductular hyperplasia in which liver is almost totally replaced with well-differentiated bile ductules.
The American journal of pathology 1994;144(6):1257-68.
1993: L W Elmore; Alphonse E Sirica
"Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan.
Cancer research 1993;53(2):254-9.
1992: L W Elmore; Alphonse E Sirica
Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats.
Hepatology (Baltimore, Md.) 1992;16(5):1220-6.
1992: Alphonse E Sirica; T W Williams
Appearance of ductular hepatocytes in rat liver after bile duct ligation and subsequent zone 3 necrosis by carbon tetrachloride.
The American journal of pathology 1992;140(1):129-36.
1992: Alphonse E Sirica
Biology of biliary epithelial cells.
Progress in liver diseases 1992;10():63-87.
1991: L W Elmore; Alphonse E Sirica
Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.
Cancer research 1991;51(20):5752-9.
1991: Alphonse E Sirica; L W Elmore; N Sano
Characterization of rat hyperplastic bile ductular epithelial cells in culture and in vivo.
Digestive diseases and sciences 1991;36(4):494-501.
1991: G A Mathis; P A Wyss; Erin G Schuetz; R P Hughey; Alphonse E Sirica
Expression of multiple proteins structurally related to gamma-glutamyl transpeptidase in non-neoplastic adult rat hepatocytes in vivo and in culture.
Journal of cellular physiology 1991;146(2):234-41.
1990: G A Mathis; Alphonse E Sirica
Effects of medium and substratum conditions on the rates of DNA synthesis in primary cultures of bile ductular epithelial cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(2):113-8.
1990: Alphonse E Sirica; G A Mathis; N Sano; L W Elmore
Isolation, culture, and transplantation of intrahepatic biliary epithelial cells and oval cells.
Pathobiology : journal of immunopathology, molecular and cellular biology 1990;58(1):44-64.
1989: Alphonse E Sirica; C S Wilkerson; L L Wu; R Fitzgerald; R V Blanke; P S Guzelian
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Carcinogenesis 1989;10(6):1047-54.
1989: G A Mathis; S A Walls; P D'Amico; T F Gengo; Alphonse E Sirica
Enzyme profile of rat bile ductular epithelial cells in reference to the resistance phenotype in hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1989;9(3):477-85.
1988: G A Mathis; S A Walls; Alphonse E Sirica
Biochemical characteristics of hyperplastic rat bile ductular epithelial cells cultured "on top" and "inside" different extracellular matrix substitutes.
Cancer research 1988;48(21):6145-53.