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Sangram Sisodia

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Christina J Crump; Douglas S Johnson; Kelly R Bales; T Eric Ballard; Suita V Castro; Nikolay Pozdnyakov; Sangram S Sisodia; Feng Wang; Yue-Ming Li
BMS-708,163 targets presenilin and lacks notch-sparing activity.
Xulun Zhang; Karthikeyan Veeraraghavalu; Brian Wilburn; Krassimira Garbett; Reid Gilmore; Károly Mirnics; Sangram S Sisodia
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Xulun Zhang; Rong Wang; Kwangwook Ahn; Georgia Dolios; Robert J Hoey; Takeshi Ikeuchi; Akiko Koide; Shohei Koide; Brenda Leung; Yue-Ming Li; Guoqing Lin; Marcin Paduch; Sangram S Sisodia
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.

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2012: Christina J Crump; Douglas S Johnson; Kelly R Bales; T Eric Ballard; Suita V Castro; Nikolay Pozdnyakov; Sangram S Sisodia; Feng Wang; Yue-Ming Li
BMS-708,163 targets presenilin and lacks notch-sparing activity.
Biochemistry 2012;51(37):7209-11.
2012: Xulun Zhang; Karthikeyan Veeraraghavalu; Brian Wilburn; Krassimira Garbett; Reid Gilmore; Károly Mirnics; Sangram S Sisodia
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(25):8633-48.
2012: Xulun Zhang; Rong Wang; Kwangwook Ahn; Georgia Dolios; Robert J Hoey; Takeshi Ikeuchi; Akiko Koide; Shohei Koide; Brenda Leung; Yue-Ming Li; Guoqing Lin; Marcin Paduch; Sangram S Sisodia
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8534-9.
2011: Marco Prinz; Josef Priller; Sangram S Sisodia; Richard M Ransohoff
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.
Nature neuroscience 2011;14(10):1227-35.
2011: Fabiana Renzi; William J Rice; Sangram S Sisodia; Celia Torres-Arancivia; Kwangwook Ahn; Ruben Diaz; Yacob Gomez-Llorente; Yue-Ming Li; Chunjiang Yu; Xulun Zhang; Iban Ubarretxena-Belandia
Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.
The Journal of biological chemistry 2011;286(24):21440-9.
2011: Tong Li; Yue-Ming Li; Donald L Price; Sangram S Sisodia; Kwangwook Ahn; Philip C Wong
Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
PloS one 2011;6(11):e28179.
2010: Kwangwook Ahn; Christopher C Shelton; Yuan Tian; Xulun Zhang; M Lane Gilchrist; Sangram S Sisodia; Yue-Ming Li
Activation and intrinsic gamma-secretase activity of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21435-40.
2010: Eric M Norstrom; Can Zhang; Rudolph E Tanzi; Sangram S Sisodia
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(46):15677-85.
2010: Maria Z Kounnas; Anne M Danks; Soan Cheng; Curtis Tyree; Elizabeth Ackerman; Xulun Zhang; Kwangwook Ahn; Phuong Nguyen; Dan Comer; Long Mao; Chengzhi Yu; David Pleynet; Paul J Digregorio; Gonul Velicelebi; Kenneth A Stauderman; William T Comer; William C Mobley; Yue-Ming Li; Sangram S Sisodia; Rudolph E Tanzi; Steven L Wagner
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Neuron 2010;67(5):769-80.
2010: Karthikeyan Veeraraghavalu; Se Hoon Choi; Xiaoqiong Zhang; Sangram S Sisodia
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(20):6903-15.
2010: Wei Wei; Louis N Nguyen; Helmut W Kessels; Hiroaki Hagiwara; Sangram S Sisodia; Roberto Malinow
Amyloid beta from axons and dendrites reduces local spine number and plasticity.
Nature neuroscience 2010;13(2):190-6.
2010: Karthikeyan Veeraraghavalu; Se Hoon Choi; Sangram S Sisodia
Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.
Neuro-degenerative diseases 2010;7(1-3):46-9.
2009: Lisa Placanica; Leonid Tarassishin; Guangli Yang; Erica Peethumnongsin; Seong-Hun Kim; Hui Zheng; Sangram S Sisodia; Yueming Li
Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
The Journal of biological chemistry 2009;284(5):2967-77.
2009: Se Hoon Choi; Yun Li; Luis F Parada; Sangram S Sisodia
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF.
Molecular neurodegeneration 2009;4():52.
2009: Matthias Meier; Julia Kennedy-Darling; Se Hoon Choi; Eric M Norstrom; Sangram S Sisodia; Wenbin Du
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.
Angewandte Chemie (International ed. in English) 2009;48(8):1487-9.
2008: Irfan Y Tamboli; Kai Prager; Dietmar R Thal; Karin M Thelen; Ilse Dewachter; Claus U Pietrzik; Peter St George-Hyslop; Sangram S Sisodia; Bart De Strooper; Michael T Heneka; Mikhail A Filippov; Ulrike Müller; Fred Van Leuven; Dieter Lütjohann; Jochen Walter
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):12097-106.
2008: Se Hoon Choi; Karthikeyan Veeraraghavalu; Orly Lazarov; Seoan Marler; Richard M Ransohoff; Jan-Marino Ramirez; Sangram S Sisodia
Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Neuron 2008;59(4):568-80.
2008: Kulandaivelu S Vetrivel; Xulun Zhang; Xavier Meckler; Haipeng Cheng; Sungho Lee; Ping Gong; Kryslaine O Lopes; Ying Chen; Nobuhisa Iwata; Ke-Jie Yin; Jin-Moo Lee; Angèle T Parent; Takaomi C Saido; Yueming Li; Sangram S Sisodia; Gopal Thinakaran
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
The Journal of biological chemistry 2008;283(28):19489-98.
2008: Qian Chen; Akira Nakajima; Se Hoon Choi; Xiaoli Xiong; Sangram S Sisodia; Ya-Ping Tang
Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Neurobiology of disease 2008;29(2):316-26.
2008: Károly Mirnics; Eric M Norstrom; Krassimira Garbett; Se Hoon Choi; Xiaoqiong Zhang; Philip Ebert; Sangram S Sisodia
Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
Molecular neurodegeneration 2008;3():14.
2007: Jinoh Kim; Bertrand Kleizen; Regina Choy; Gopal Thinakaran; Sangram S Sisodia; Randy Schekman
Biogenesis of gamma-secretase early in the secretory pathway.
The Journal of cell biology 2007;179(5):951-63.
2007: Hiroyuki Kaneko; Akiyoshi Kakita; Kensaku Kasuga; Hiroaki Nozaki; Atsushi Ishikawa; Akinori Miyashita; Ryozo Kuwano; Genta Ito; Takeshi Iwatsubo; Hitoshi Takahashi; Masatoyo Nishizawa; Osamu Onodera; Sangram S Sisodia; Takeshi Ikeuchi
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13092-7.
2007: Hookang Im; Marika Manolopoulou; Enrico Malito; Yuequan Shen; Ji Zhao; Marie Neant-Fery; Ching-Yu Sun; Stephen C Meredith; Sangram S Sisodia; Malcolm Leissring; Wei-Jen Tang
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
The Journal of biological chemistry 2007;282(35):25453-63.
2007: Orly Lazarov; Gerardo Morfini; Gustavo Pigino; Archana Gadadhar; Xiangjun Chen; John Robinson; Hanson Ho; Scott T Brady; Sangram S Sisodia
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(26):7011-20.
2007: Se Hoon Choi; Susan N Leight; Virginia M-Y Lee; Tong Li; Philip C Wong; Jeffrey A Johnson; Maria J Saraiva; Sangram S Sisodia
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(26):7006-10.
2007: Chian-Yu Peng; Hiroshi Yajima; Caroline Erter Burns; Leonard I Zon; Sangram S Sisodia; Samuel L Pfaff; Kamal Sharma
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.
Neuron 2007;53(6):813-27.
2006: Helen Hsieh; Jannic Boehm; Chihiro Sato; Takeshi Iwatsubo; Taisuke Tomita; Sangram S Sisodia; Roberto Malinow
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Neuron 2006;52(5):831-43.
2006: Gopal Thinakaran; Sangram S Sisodia
Presenilins and Alzheimer disease: the calcium conspiracy.
Nature neuroscience 2006;9(11):1354-5.
2006: Seong-Hun Kim; Ya-Ping Tang; Sangram S Sisodia
Abeta star: a light onto synaptic dysfunction?
Nature medicine 2006;12(7):760-1; discussion 761.
2006: Dongming Cai; William Netzer; Minghao Zhong; Yixin Lin; Guangwei Du; Michael Frohman; David A Foster; Sangram S Sisodia; Huaxi Xu; Fred S Gorelick; Paul Greengard
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1941-6.
2006: Dongming Cai; Minghao Zhong; Runsheng Wang; William Netzer; Dennis Shields; Hui Zheng; Sangram S Sisodia; David A Foster; Fred S Gorelick; Huaxi Xu; Paul Greengard
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1936-40.
2006: Orly Lazarov; Letia D Peterson; Daniel A Peterson; Sangram S Sisodia
Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):429-34.
2005: Seong-Hun Kim; Sangram S Sisodia
Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.
The Journal of biological chemistry 2005;280(51):41953-66.
2005: Travis Unger; Zeljka Korade; Orly Lazarov; David Terrano; Nina F Schor; Sangram S Sisodia; Károly Mirnics
Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2005;13(12):1041-51.
2005: Zeljka Korade Mirnics; Chaohua Yan; Carmel Portugal; TAE-WAN KIM; H Uri Saragovi; Sangram S Sisodia; Károly Mirnics; Nina F Schor
P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Neurobiology of disease 2005;20(3):969-85.
2005: Sylvia E Perez; Orly Lazarov; James B Koprich; Er-Yun Chen; Virginia Rodriguez-Menendez; Jack William Lipton; Sangram S Sisodia; Elliott J Mufson
Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(44):10220-9.
2005: Travis Unger; Zeljka Korade; Orly Lazarov; David Terrano; Sangram S Sisodia; Károly Mirnics
True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.
Methods (San Diego, Calif.) 2005;37(3):261-73.
2005: Kulandaivelu S Vetrivel; Haipeng Cheng; Seong-Hun Kim; Ying Chen; Natalie Y Barnes; Angèle T Parent; Sangram S Sisodia; Gopal Thinakaran
Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
The Journal of biological chemistry 2005;280(27):25892-900.
2005: Orly Lazarov; John Robinson; Ya-Ping Tang; Ilana S Hairston; Zeljka Korade-Mirnics; Virginia M-Y Lee; Louis B Hersh; Robert M Sapolsky; Károly Mirnics; Sangram S Sisodia
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Cell 2005;120(5):701-13.
2005: Orly Lazarov; Gerardo Morfini; Edward B Lee; Mohamed H Farah; Anita Szodorai; Scott R DeBoer; Vassilis E Koliatsos; Stefan Kins; Virginia M-Y Lee; Philip C Wong; Donald L Price; Scott T Brady; Sangram S Sisodia
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2386-95.
2005: Károly Mirnics; Zeljka Korade; Dominique Arion; Orly Lazarov; Travis Unger; Melissa Macioce; Michael Sabatini; David Terrano; Katherine C Douglass; Nina F Schor; Sangram S Sisodia
Presenilin-1-dependent transcriptome changes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(6):1571-8.
2005: Angèle T Parent; Natalie Y Barnes; Yoshihito Taniguchi; Gopal Thinakaran; Sangram S Sisodia
Presenilin attenuates receptor-mediated signaling and synaptic function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(6):1540-9.
2005: Seong-Hun Kim; Sangram S Sisodia
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.
The Journal of biological chemistry 2005;280(3):1992-2001.
2004: Seong-Hun Kim; Ye Ingrid Yin; Yueming Li; Sangram S Sisodia
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
The Journal of biological chemistry 2004;279(47):48615-9.
2004: Jochen Herms; Brigitte Anliker; Sabine Heber; Sabine Ring; Martin Fuhrmann; Hans A Kretzschmar; Sangram S Sisodia; Ulrike Müller
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.
The EMBO journal 2004;23(20):4106-15.
2004: Angeliki Louvi; Sangram S Sisodia; Elizabeth A Grove
Presenilin 1 in migration and morphogenesis in the central nervous system.
Development (Cambridge, England) 2004;131(13):3093-105.
2003: Zeljka Korade Mirnics; Károly Mirnics; David Terrano; D A Lewis; Sangram S Sisodia; Nina F Schor
DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
Molecular psychiatry 2003;8(10):863-78.
2003: Seong-Hun Kim; Takeshi Ikeuchi; Chunjiang Yu; Sangram S Sisodia
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
The Journal of biological chemistry 2003;278(36):33992-4002.
2003: Yoshihito Taniguchi; Seong-Hun Kim; Sangram S Sisodia
Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).
The Journal of biological chemistry 2003;278(33):30425-8.
2003: Flavio Kamenetz; Taisuke Tomita; Helen Hsieh; Guy Seabrook; David R Borchelt; Takeshi Iwatsubo; Sangram S Sisodia; Roberto Malinow
APP processing and synaptic function.
Neuron 2003;37(6):925-37.
2003: Takeshi Ikeuchi; Sangram S Sisodia
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
The Journal of biological chemistry 2003;278(10):7751-4.
2003: Takeshi Ikeuchi; Georgia Dolios; Seong-Hun Kim; Rong Wang; Sangram S Sisodia
Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
The Journal of biological chemistry 2003;278(9):7010-8.
2003: Dongming Cai; Jae Yoon Leem; Jeffrey P Greenfield; Pei Wang; Benny S Kim; Runsheng Wang; Kryslaine O Lopes; Seong-Hun Kim; Hui Zheng; Paul Greengard; Sangram S Sisodia; Gopal Thinakaran; Huaxi Xu
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(5):3446-54.
2002: Orly Lazarov; Michael K Lee; Daniel A Peterson; Sangram S Sisodia
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(22):9785-93.
2002: Sangram S Sisodia; Peter St George-Hyslop
gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
Nature reviews. Neuroscience 2002;3(4):281-90.
2002: David R Borchelt; Michael K Lee; Victoria Gonzales; Hilda H Slunt; TAMARA RATOVITSKI; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Neurobiology of aging 2002;23(2):171-7.
2002: Sangram S Sisodia
Biomedicine. A cargo receptor mystery APParently solved?
Science (New York, N.Y.) 2002;295(5556):805-7.
2002: Walter Kalback; M Desiree Watson; Tyler A Kokjohn; Yu-Min Kuo; Nicole Weiss; Dean C Luehrs; John Lopez; Daniel C Brune; Sangram S Sisodia; Matthias Staufenbiel; Mark Emmerling; Alex Roher
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Biochemistry 2002;41(3):922-8.
2002: Seong-Hun Kim; John W M Creemers; Su Chu; Gopal Thinakaran; Sangram S Sisodia
Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.
The Journal of biological chemistry 2002;277(3):1872-7.
2002: Takeshi Ikeuchi; Sangram S Sisodia
Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Neuromolecular medicine 2002;1(1):43-54.
2002: Zeljka Korade Mirinics; Jero Calafat; Lene Udby; Josh Lovelock; Lars Kjeldsen; Kristi Rothermund; Sangram S Sisodia; Niels Borregaard; Seth J Corey
Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.
Blood cells, molecules & diseases 2002;28(1):28-38.
2001: Ruiben Feng; C Rampon; Ya-Ping Tang; David Shrom; J Jin; Maureen Kyin; Bryce L Sopher; M W Miller; C B Ware; George M Martin; Seong-Hun Kim; R B Langdon; Sangram S Sisodia; Joseph Zhuo Tsien
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Neuron 2001;32(5):911-26.
2001: Chunjiang Yu; Seong-Hun Kim; Takeshi Ikeuchi; Huaxi Xu; L Gasparini; Rong Wang; Sangram S Sisodia
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
The Journal of biological chemistry 2001;276(47):43756-60.
2001: Seong-Hun Kim; Jae Yoon Leem; James J Lah; Hilda H Slunt; Allan Levey; Gopal Thinakaran; Sangram S Sisodia
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
The Journal of biological chemistry 2001;276(46):43343-50.
2001: Sangram S Sisodia; Willem ANNAERT; Seong-Hun Kim; Bart De Strooper
Gamma-secretase: never more enigmatic.
Trends in neurosciences 2001;24(11 Suppl):S2-6.
2001: Suzanne Benjannet; A Elagoz; Louise Wickham; M Mamarbachi; JS Munzer; Ajoy Basak; Claude Lazure; James A Cromlish; Sangram S Sisodia; F Checler; Michel Chrétien; Nabil G Seidah
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
The Journal of biological chemistry 2001;276(14):10879-87.
2000: J L Martys-Zage; Seong-Hun Kim; Bridget E Berechid; S J Bingham; S Chu; J Sklar; J Nye; Sangram S Sisodia
Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Journal of molecular neuroscience : MN 2000;15(3):189-204.
2000: N Sato; F Urano; J Yoon Leem; Seong-Hun Kim; M Li; D Donoviel; A Bernstein; A S Lee; D Ron; Margaret L Veselits; Sangram S Sisodia; Gopal Thinakaran
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Nature cell biology 2000;2(12):863-70.
2000: Masaaki Takahashi; Sylvain Dore; Christopher D Ferris; Taisuke Tomita; Akira Sawa; H Wolosker; David R Borchelt; Takeshi Iwatsubo; Seong-Hun Kim; Gopal Thinakaran; Sangram S Sisodia; Solomon H Snyder
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: S Heber; Jochen Herms; V Gajic; J Hainfellner; A Aguzzi; T Rülicke; H von Kretzschmar; C von Koch; Sangram S Sisodia; P Tremml; Hans-Peter Lipp; David P Wolfer; U Müller
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):7951-63.
2000: Sangram S Sisodia
Neuroscience. An accomplice for gamma-secretase brought into focus.
Science (New York, N.Y.) 2000;289(5488):2296-7.
2000: Seong-Hun Kim; James J Lah; Gopal Thinakaran; Allan Levey; Sangram S Sisodia
Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Neurobiology of disease 2000;7(2):99-117.
2000: S H Zaman; Angèle T Parent; A Laskey; Michael K Lee; David R Borchelt; Sangram S Sisodia; Roberto Malinow
Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Neurobiology of disease 2000;7(1):54-63.
2000: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; Gopal Thinakaran; David G Lynn; Stephen C Meredith; Sangram S Sisodia
Familial British dementia: expression and metabolism of BRI.
Annals of the New York Academy of Sciences 2000;920():93-9.
2000: Donald L Price; Philip C Wong; Alicja L Markowska; Michael K Lee; G Thinakaren; Don W Cleveland; Sangram S Sisodia; David R Borchelt
The value of transgenic models for the study of neurodegenerative diseases.
Annals of the New York Academy of Sciences 2000;920():179-91.
1999: Bridget E Berechid; Gopal Thinakaran; Philip C Wong; Sangram S Sisodia; Jeffrey S Nye
Lack of requirement for presenilin1 in Notch1 signaling.
Current biology : CB 1999;9(24):1493-6.
1999: Sangram S Sisodia
Alzheimer's disease: perspectives for the new millennium.
The Journal of clinical investigation 1999;104(9):1169-70.
1999: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; David G Lynn; Gopal Thinakaran; Stephen C Meredith; Sangram S Sisodia
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Nature neuroscience 1999;2(11):984-8.
1999: X F Li; Gopal Thinakaran; Sangram S Sisodia; Fu-Shin X Yu
Amyloid precursor-like protein 2 promotes cell migration toward fibronectin and collagen IV.
The Journal of biological chemistry 1999;274(38):27249-56.
1999: Bruce Lamb; K A Bardel; Laura Shapiro Kulnane; J J Anderson; Greg Holtz; Steven L Wagner; Sangram S Sisodia; E J Hoeger
Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Nature neuroscience 1999;2(8):695-7.
1999: Sangram S Sisodia; Seong-Hun Kim; Gopal Thinakaran
Function and dysfunction of the presenilins.
American journal of human genetics 1999;65(1):7-12.
1999: David E Kang; Salvador Soriano; M P Frosch; T Collins; S Naruse; Sangram S Sisodia; G Leibowitz; Fred Levine; Edward H Koo
Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(11):4229-37.
1999: Angèle T Parent; David J Linden; Sangram S Sisodia; David R Borchelt
Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Neurobiology of disease 1999;6(1):56-62.
1999: Jeffrey P Greenfield; J Tsai; Gunnar K Gouras; B Hai; Gopal Thinakaran; F Checler; Sangram S Sisodia; Paul Greengard; Huaxi Xu
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):742-7.
1998: Joseph Buxbaum; Gopal Thinakaran; Vassilis E Koliatsos; J O'Callahan; Hilda H Slunt; Donald L Price; Sangram S Sisodia
Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9629-37.
1998: Donald L Price; Sangram S Sisodia; David R Borchelt
Genetic neurodegenerative diseases: the human illness and transgenic models.
Science (New York, N.Y.) 1998;282(5391):1079-83.
1998: S Naruse; Gopal Thinakaran; JJ Luo; John W Kusiak; Taisuke Tomita; Takeshi Iwatsubo; X Qian; David D Ginty; Donald L Price; David R Borchelt; Philip C Wong; Sangram S Sisodia
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Neuron 1998;21(5):1213-21.
1998: Sangram S Sisodia; Michela Gallagher
A role for the beta-amyloid precursor protein in memory?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12074-6.
1998: Sangram S Sisodia
Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?
Cell 1998;95(1):1-4.
1998: David R Borchelt; Philip C Wong; Sangram S Sisodia; Donald L Price
Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Brain pathology (Zurich, Switzerland) 1998;8(4):735-57.
1998: A Tam; Franklin J Nouvet; K Fujimura-Kamada; Hilda H Slunt; Sangram S Sisodia; Susan Michaelis
Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing.
The Journal of cell biology 1998;142(3):635-49.
1998: Donald L Price; Sangram S Sisodia; David R Borchelt
Alzheimer disease--when and why?
Nature genetics 1998;19(4):314-6.
1998: David R Borchelt; Philip C Wong; Mark W Becher; CARLOS PARDO-VILLAMIZAR; Michael K Lee; Z S Xu; Gopal Thinakaran; Nancy A Jenkins; Neal G Copeland; Sangram S Sisodia; Don W Cleveland; Donald L Price; Paul N Hoffman
Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Neurobiology of disease 1998;5(1):27-35.
1998: Alvin W Lyckman; AM Confaloni; Gopal Thinakaran; Sangram S Sisodia; KL Moya
Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system.
The Journal of biological chemistry 1998;273(18):11100-6.
1998: Gopal Thinakaran; J B Regard; Christopher MLS Bouton; CL Harris; Donald L Price; David R Borchelt; Sangram S Sisodia
Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Neurobiology of disease 1998;4(6):438-53.
1998: Huaxi Xu; Gunnar K Gouras; Jeffrey P Greenfield; B Vincent; J Naslund; L Mazzarelli; G Fried; J N Jovanovic; M Seeger; Norman Richard Relkin; F Liao; F Checler; Joseph Buxbaum; Brian T Chait; Gopal Thinakaran; Sangram S Sisodia; Runsheng Wang; Paul Greengard; Sam Gandy
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Nature medicine 1998;4(4):447-51.
1998: J A Davis; S Naruse; Honglin Chen; Christopher B Eckman; Steven G Younkin; Donald L Price; David R Borchelt; Sangram S Sisodia; Philip C Wong
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Neuron 1998;20(3):603-9.
1998: J Guo; Gopal Thinakaran; Y Guo; Sangram S Sisodia; Fu-Shin X Yu
A role for amyloid precursor-like protein 2 in corneal epithelial wound healing.
Investigative ophthalmology & visual science 1998;39(2):292-300.
1998: Philip C Wong; David R Borchelt; Michael K Lee; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Lee J Martin; Sangram S Sisodia; Donald L Price
Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models.
Advances in experimental medicine and biology 1998;446():145-59.
1998: Donald L Price; Rudolph E Tanzi; David R Borchelt; Sangram S Sisodia
Alzheimer's disease: genetic studies and transgenic models.
Annual review of genetics 1998;32():461-93.
1998: Donald L Price; Sangram S Sisodia
Mutant genes in familial Alzheimer's disease and transgenic models.
Annual review of neuroscience 1998;21():479-505.
1997: A Bergin; G Kim; Donald L Price; Sangram S Sisodia; Michael K Lee; B A Rabin
Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron.
Gene 1997;204(1-2):47-53.
1997: Gopal Thinakaran; CL Harris; TAMARA RATOVITSKI; F Davenport; Hilda H Slunt; Donald L Price; David R Borchelt; Sangram S Sisodia
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
The Journal of biological chemistry 1997;272(45):28415-22.
1997: C S von Koch; Hui Zheng; H Chen; Myrna E Trumbauer; Gopal Thinakaran; Lex H T Van Der Ploeg; Donald L Price; Sangram S Sisodia
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
Neurobiology of aging 1997;18(6):661-9.
1997: David R Borchelt; TAMARA RATOVITSKI; J van Lare; Michael K Lee; Victoria Gonzales; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Neuron 1997;19(4):939-45.
1997: TAMARA RATOVITSKI; Hilda H Slunt; Gopal Thinakaran; Donald L Price; Sangram S Sisodia; David R Borchelt
Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
The Journal of biological chemistry 1997;272(39):24536-41.
1997: Donald L Price; Philip C Wong; David R Borchelt; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; AP Doan; Michael K Lee; Lee J Martin; Sangram S Sisodia
Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems.
Revue neurologique 1997;153(8-9):484-95.
1997: Bruce Lamb; LM Call; Hilda H Slunt; K A Bardel; Ann M Lawler; Christopher B Eckman; Steven G Younkin; Greg Holtz; Steven L Wagner; Donald L Price; Sangram S Sisodia; John D Gearhart
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Human molecular genetics 1997;6(9):1535-41.
1997: Michael K Lee; David R Borchelt; G Kim; Gopal Thinakaran; Hilda H Slunt; TAMARA RATOVITSKI; Lee J Martin; A Kittur; Sam Gandy; Allan Levey; Nancy Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Nature medicine 1997;3(7):756-60.
1997: Philip C Wong; Hui Zheng; Honglin Chen; Mark W Becher; DJ Sirinathsinghji; Myrna E Trumbauer; H Y Chen; Donald L Price; Lex H T Van Der Ploeg; Sangram S Sisodia
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Nature 1997;387(6630):288-92.
1997: M Seeger; C Nordstedt; Suzana Petanceska; Dora M. Kovacs; Gunnar K Gouras; S Hahne; Paul E Fraser; L Levesque; Andrew J Czernik; Peter St George-Hyslop; Sangram S Sisodia; Gopal Thinakaran; Rudolph E Tanzi; Paul Greengard; Sam Gandy
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5090-4.
1997: L Hendriks; Gopal Thinakaran; C L Harris; Chris De Jonghe; Jean-Jacques Martin; Sangram S Sisodia; Christine Van Broeckhoven
Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.
Neuroreport 1997;8(7):1717-21.
1997: H L Li; J M Roch; M Sundsmo; Dennis C Otero; Sangram S Sisodia; R Thomas; T Saitoh
Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease.
Journal of neurobiology 1997;32(5):469-80.
1997: Huaxi Xu; D Sweeney; Rong Wang; Gopal Thinakaran; Amy Lo; Sangram S Sisodia; Paul Greengard; Sam Gandy
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3748-52.
1997: Lucie I Bruijn; Mark W Becher; Michael K Lee; K L Anderson; N A Jenkins; N G Copeland; Sangram S Sisodia; Jeffrey rothstein; David R Borchelt; Donald L Price; Don W Cleveland
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.
Neuron 1997;18(2):327-38.
1997: B Zhao; Francis J Chrest; W E Horton; Sangram S Sisodia; John W Kusiak
Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.
Journal of neuroscience research 1997;47(3):253-63.
1997: Jochen Walter; Anja Capell; A Y Hung; H Langen; M Schnölzer; Gopal Thinakaran; Sangram S Sisodia; Dennis J Selkoe; Christian Haass
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: NR Marquez-Sterling; Amy Lo; Sangram S Sisodia; Edward H Koo
Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(1):140-51.
1996: Rong Wang; D Sweeney; Sam Gandy; Sangram S Sisodia
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry.
The Journal of biological chemistry 1996;271(50):31894-902.
1996: D Levitan; T G Doyle; D Brousseau; Michael K Lee; Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia; Iva Greenwald
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14940-4.
1996: David R Borchelt; J Davis; M Fischer; Michael K Lee; Hilda H Slunt; T Ratovitsky; J Regard; Neal G Copeland; Nancy A Jenkins; Sangram S Sisodia; Donald L Price
A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Genetic analysis : biomolecular engineering 1996;13(6):159-63.
1996: Michael K Lee; Hilda H Slunt; Lee J Martin; Gopal Thinakaran; G Kim; Sam Gandy; M Seeger; Edward H Koo; Donald L Price; Sangram S Sisodia
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7513-25.
1996: AP Doan; Gopal Thinakaran; David R Borchelt; Hilda H Slunt; T Ratovitsky; M Podlisny; Dennis J Selkoe; M Seeger; Sam Gandy; Donald L Price; Sangram S Sisodia
Protein topology of presenilin 1.
Neuron 1996;17(5):1023-30.
1996: David R Borchelt; Gopal Thinakaran; Christopher B Eckman; Michael K Lee; F Davenport; T Ratovitsky; CM Prada; G Kim; S Seekins; Debra Yager; Hilda H Slunt; Rong Wang; M Seeger; Allan Levey; Sam Gandy; Neal G Copeland; Nancy A Jenkins; Donald L Price; Steven G Younkin; Sangram S Sisodia
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Neuron 1996;17(5):1005-13.
1996: Donald L Price; Mark W Becher; Philip C Wong; David R Borchelt; Michael K Lee; Sangram S Sisodia
Inherited neurodegenerative diseases and transgenic models.
Brain pathology (Zurich, Switzerland) 1996;6(4):467-80.
1996: Michael K Lee; David R Borchelt; Philip C Wong; Sangram S Sisodia; Donald L Price
Transgenic models of neurodegenerative diseases.
Current opinion in neurobiology 1996;6(5):651-60.
1996: S L Bressler; Matthew D Gray; Bryce L Sopher; Qubai Hu; M G Hearn; D G Pham; MB Dinulos; Ken-Ichiro Fukuchi; Sangram S Sisodia; M A Miller; Christine M Disteche; George M Martin
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Human molecular genetics 1996;5(10):1589-98.
1996: Barbara J Crain; W Hu; C I Sze; Hilda H Slunt; Edward H Koo; Donald L Price; Gopal Thinakaran; Sangram S Sisodia
Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain.
The American journal of pathology 1996;149(4):1087-95.
1996: Don W Cleveland; Lucie I Bruijn; Philip C Wong; J R Marszalek; J D Vechio; Michael K Lee; X S Xu; David R Borchelt; Sangram S Sisodia; Donald L Price
Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.
Neurology 1996;47(4 Suppl 2):S54-61; discussion S61-2.
1996: Noel Y Calingasan; Sam Gandy; H Baker; KF Sheu; Jonathan D. Smith; Bruce Lamb; John D Gearhart; Joseph Buxbaum; C Harper; Dennis J Selkoe; Donald L Price; Sangram S Sisodia; Gary Gibson
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
The American journal of pathology 1996;149(3):1063-71.
1996: David R Borchelt; Sangram S Sisodia
Loss of functional prion protein: a role in prion disorders?
Chemistry & biology 1996;3(8):619-21.
1996: Gopal Thinakaran; David R Borchelt; Michael K Lee; Hilda H Slunt; L Spitzer; G Kim; T Ratovitsky; F Davenport; C Nordstedt; M Seeger; John Hardy; Allan Levey; Sam Gandy; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Neuron 1996;17(1):181-90.
1996: Gopal Thinakaran; David B Teplow; R Siman; Barry D Greenberg; Sangram S Sisodia
Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
The Journal of biological chemistry 1996;271(16):9390-7.
1996: Sangram S Sisodia; Gopal Thinakaran; Hilda H Slunt; C A Kitt; C S Von Koch; Randall R Reed; H Zheng; Donald L Price
Studies on the metabolism and biological function of APLP2.
Annals of the New York Academy of Sciences 1996;777():77-81.
1996: Hui Zheng; M Jiang; M E Trumbauer; R Hopkins; DJ Sirinathsinghji; K A Stevens; M W Conner; H H Slunt; Sangram S Sisodia; H Y Chen; Lex H T Van Der Ploeg
Mice deficient for the amyloid precursor protein gene.
Annals of the New York Academy of Sciences 1996;777():421-6.
1996: Donald L Price; David R Borchelt; Philip C Wong; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Michael K Lee; Don W Cleveland; Sangram S Sisodia
Neurodegenerative diseases and model systems.
Cold Spring Harbor symposia on quantitative biology 1996;61():725-38.
1996: Donald L Price; Vassilis E Koliatsos; Philip C Wong; CARLOS PARDO-VILLAMIZAR; David R Borchelt; Michael K Lee; Don W Cleveland; John W Griffin; Paul N Hoffman; L C Cork; Sangram S Sisodia
Motor neuron disease and model systems: aetiologies, mechanisms and therapies.
Ciba Foundation symposium 1996;196():3-13; discussion 13-7.
1995: C S von Koch; Debomoy K Lahiri; Alex Mammen; Neal G Copeland; D J Gilbert; Nancy A Jenkins; Sangram S Sisodia
The mouse APLP2 gene. Chromosomal localization and promoter characterization.
The Journal of biological chemistry 1995;270(43):25475-80.
1995: Roger H Reeves; N G Irving; Timothy H Moran; A Wohn; C Kitt; Sangram S Sisodia; C Schmidt; R T Bronson; Muriel T Davisson
A mouse model for Down syndrome exhibits learning and behaviour deficits.
Nature genetics 1995;11(2):177-84.
1995: Donald L Price; Sangram S Sisodia; Sam Gandy
Amyloid beta amyloidosis in Alzheimer's disease.
Current opinion in neurology 1995;8(4):268-74.
1995: Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia
Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2.
The Journal of biological chemistry 1995;270(28):16522-5.
1995: Philip C Wong; CARLOS PARDO-VILLAMIZAR; David R Borchelt; Michael K Lee; Neal G Copeland; Nancy A Jenkins; Sangram S Sisodia; Don W Cleveland; Donald L Price
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.
Neuron 1995;14(6):1105-16.
1995: Amy Lo; Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia
Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain.
The Journal of biological chemistry 1995;270(21):12641-5.
1995: Shahrooz Rabizadeh; Edith Butler Gralla; David R Borchelt; R Gwinn; Joan Selverstone Valentine; Sangram S Sisodia; Philip C Wong; Michael K Lee; H Hahn; Dale E Bredesen
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3024-8.
1995: Sangram S Sisodia; Donald L Price
Role of the beta-amyloid protein in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(5):366-70.
1995: A Lai; Sangram S Sisodia; IS Trowbridge
Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain.
The Journal of biological chemistry 1995;270(8):3565-73.
1995: David R Borchelt; M Guarnieri; Philip C Wong; Michael K Lee; H S Slunt; Z S Xu; Sangram S Sisodia; Donald L Price; Don W Cleveland
Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.
The Journal of biological chemistry 1995;270(7):3234-8.
1995: CARLOS PARDO-VILLAMIZAR; Z Xu; David R Borchelt; Donald L Price; Sangram S Sisodia; Don W Cleveland
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):954-8.
1995: B Zhao; Sangram S Sisodia; John W Kusiak
Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.
Journal of neuroscience research 1995;40(2):261-8.
1995: Sangram S Sisodia; Lee J Martin; Lary Walker; David R Borchelt; Donald L Price
Cellular and molecular biology of Alzheimer's disease and animal models.
Neuroimaging clinics of North America 1995;5(1):59-68.
1994: William E Van Nostrand; Alvin H Schmaier; B R Neiditch; R S Siegel; W C Raschke; Sangram S Sisodia; S L Wagner
Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2.
Biochimica et biophysica acta 1994;1209(2):165-70.
1994: Amy Lo; Christian Haass; S L Wagner; David B Teplow; Sangram S Sisodia
Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1994;269(49):30966-73.
1994: Gopal Thinakaran; Sangram S Sisodia
Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.
The Journal of biological chemistry 1994;269(35):22099-104.
1994: David R Borchelt; Michael K Lee; H S Slunt; M Guarnieri; Z S Xu; Philip C Wong; R H Brown; Donald L Price; Sangram S Sisodia; Don W Cleveland
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8292-6.
1994: David R Borchelt; Vassilis E Koliatsos; M Guarnieri; CARLOS PARDO-VILLAMIZAR; Sangram S Sisodia; Donald L Price
Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems.
The Journal of biological chemistry 1994;269(20):14711-4.
1994: Hilda H Slunt; Gopal Thinakaran; C Von Koch; Amy Lo; Rudolph E Tanzi; Sangram S Sisodia
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
The Journal of biological chemistry 1994;269(4):2637-44.
1994: Donald L Price; Sangram S Sisodia
Cellular and molecular biology of Alzheimer's disease and animal models.
Annual review of medicine 1994;45():435-46.
1994: Sangram S Sisodia
Cellular and molecular genetic approaches in Alzheimer's disease.
Neurobiology of aging 1994;15 Suppl 2():S135-7.
1993: O A da Cruz e Silva; K Iverfeldt; Tilman Oltersdorf; S Sinha; I Lieberburg; T V Ramabhadran; T Suzuki; Sangram S Sisodia; Sam Gandy; Paul Greengard
Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail.
Neuroscience 1993;57(4):873-7.
1993: Wilma Wasco; S Gurubhagavatula; M D Paradis; Donna M Romano; Sangram S Sisodia; Bradley T Hyman; R L Neve; Rudolph E Tanzi
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Nature genetics 1993;5(1):95-100.
1993: Bruce Lamb; Sangram S Sisodia; Ann M Lawler; Hilda H Slunt; C A Kitt; William G Kearns; P L Pearson; Donald L Price; John D Gearhart
Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].
Nature genetics 1993;5(1):22-30.
1993: Donald L Price; David R Borchelt; Sangram S Sisodia
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6381-4.
1993: Sangram S Sisodia; Edward H Koo; Paul N Hoffman; George Perry; Donald L Price
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):3136-42.
1992: Sangram S Sisodia
Secretion of the beta-amyloid precursor protein.
Annals of the New York Academy of Sciences 1992;674():53-7.
1992: Donald L Price; Lee J Martin; R E Clatterbuck; Vassilis E Koliatsos; Sangram S Sisodia; Lary Walker; L C Cork
Neuronal degeneration in human diseases and animal models.
Journal of neurobiology 1992;23(9):1277-94.
1992: Sangram S Sisodia; Donald L Price
Amyloidogenesis in Alzheimer's disease: basic biology and animal models.
Current opinion in neurobiology 1992;2(5):648-52.
1992: Donald L Price; Lary Walker; Lee J Martin; Sangram S Sisodia
Amyloidosis in aging and Alzheimer's disease.
The American journal of pathology 1992;141(4):767-72.
1992: Donald L Price; David R Borchelt; Lary Walker; Sangram S Sisodia
Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease.
Neurobiology of aging 1992;13(5):623-5.
1992: Sangram S Sisodia
Beta-amyloid precursor protein cleavage by a membrane-bound protease.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6075-9.
1992: Donald L Price; Lee J Martin; Sangram S Sisodia; Lary Walker; L C Cork
Alzheimer's disease-type brain abnormalities in animal models.
Progress in clinical and biological research 1992;379():271-87.
1991: Michel Goedert; Sangram S Sisodia; Donald L Price
Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.
Current opinion in neurobiology 1991;1(3):441-7.
1991: Rong Wang; J F Meschia; Robert J Cotter; Sangram S Sisodia
Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells.
The Journal of biological chemistry 1991;266(25):16960-4.
1991: Donald L Price; Lee J Martin; Sangram S Sisodia; M V Wagster; Edward H Koo; Lary Walker; Vassilis E Koliatsos; L C Cork
Aged non-human primates: an animal model of age-associated neurodegenerative disease.
Brain pathology (Zurich, Switzerland) 1991;1(4):287-96.
1991: Lee J Martin; Sangram S Sisodia; Edward H Koo; L C Cork; T L Dellovade; Andreas Weidemann; Konrad Beyreuther; Colin L Masters; Donald L Price
Amyloid precursor protein in aged nonhuman primates.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1461-5.
1991: Donald L Price; Vassilis E Koliatsos; Sangram S Sisodia; Edward H Koo; Lee J Martin; Lary Walker; M D Appelgate; L C Cork
Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models.
Clinical neuropharmacology 1991;14 Suppl 1():S9-14.
1991: Carmela Abraham; B L Razzaboni; Sangram S Sisodia; Edward H Koo; Donald L Price; William E Van Nostrand; G Papastoitsis
Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain.
Annals of the New York Academy of Sciences 1991;640():161-5.
1990: Sangram S Sisodia; Edward H Koo; Konrad Beyreuther; A Unterbeck; Donald L Price
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.
Science (New York, N.Y.) 1990;248(4954):492-5.
1990: Edward H Koo; Sangram S Sisodia; D R Archer; Lee J Martin; Andreas Weidemann; Konrad Beyreuther; P Fischer; Colin L Masters; Donald L Price
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1561-5.
1990: Donald L Price; Sangram S Sisodia; Edward H Koo; Nancy A Muma; C A Kitt; Lary Walker; Lee J Martin; Juan C Troncoso; John W Griffin; Paul N Hoffman
Neuronal disorders: studies of animal models and human diseases.
Toxicologic pathology 1990;18(1 Pt 2):128-37.
1990: Edward H Koo; Sangram S Sisodia; L C Cork; A Unterbeck; R M Bayney; Donald L Price
Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates.
Neuron 1990;4(1):97-104.
1990: Donald L Price; Edward H Koo; Sangram S Sisodia; Lee J Martin; Vassilis E Koliatsos; Nancy A Muma; Lary Walker; L C Cork
Neuronal responses to injury and aging: lessons from animal models.
Progress in brain research 1990;86():297-308.
1990: Sangram S Sisodia; D A Gay; Don W Cleveland
In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells.
The New biologist 1990;2(1):66-76.
1989: D A Gay; Sangram S Sisodia; Don W Cleveland
Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5763-7.
1987: A Gabriel; Sangram S Sisodia; Don W Cleveland
Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata.
The Journal of biological chemistry 1987;262(33):16192-9.
1987: Sangram S Sisodia; Barbara Sollner-Webb; Don W Cleveland
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.
Molecular and cellular biology 1987;7(10):3602-12.
1987: Sangram S Sisodia; D W Cleveland; Barbara Sollner-Webb
A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing.
Nucleic acids research 1987;15(5):1995-2011.