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Frank Sistare

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TOP 3
Zoltan Erdos; Warren E Glaab; Michael Goedken; Karsten Menzel; Kara Pearson; Frank D Sistare; Louise Parks Saldutti
Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.
Wendy J Bailey; Pam Devlin; Raymond J Gonzalez; Valerie Hamilton; Diane M Hamlin; Dan Holder; Nagaraja Muniappa; Hima Patel; Frank D Sistare; Craig E Thomas; Warren E Glaab
A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
Frank D Sistare; Joseph J DeGeorge
Promise of new translational safety biomarkers in drug development and challenges to regulatory qualification.

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All Publications

2013: Zoltan Erdos; Warren E Glaab; Michael Goedken; Karsten Menzel; Kara Pearson; Frank D Sistare; Louise Parks Saldutti
Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.
Birth defects research. Part B, Developmental and reproductive toxicology 2013;98(1):41-53.
2012: Wendy J Bailey; Pam Devlin; Raymond J Gonzalez; Valerie Hamilton; Diane M Hamlin; Dan Holder; Nagaraja Muniappa; Hima Patel; Frank D Sistare; Craig E Thomas; Warren E Glaab
A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(2):229-44.
2011: Frank D Sistare; Joseph J DeGeorge
Promise of new translational safety biomarkers in drug development and challenges to regulatory qualification.
Biomarkers in medicine 2011;5(4):497-514.
2010: Karol L Thompson; Barry A Rosenzweig; Jun Zhang; Alan D Knapton; Ronald Honchel; Steven E Lipshultz; Jacques Retief; Frank D Sistare; Eugene H Herman
Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats.
Cancer chemotherapy and pharmacology 2010;66(2):303-14.
2010: Vishal S Vaidya; Josef S Ozer; Frank Dieterle; Fitz B Collings; Victoria Ramirez; Sean Troth; Nagaraja Muniappa; Douglas Thudium; David Gerhold; Daniel J Holder; Norma A Bobadilla; Estelle Marrer; Elias Perentes; André Cordier; Jacky Vonderscher; Gérard Maurer; Peter L Goering; Frank D Sistare; Joseph V Bonventre
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
Nature biotechnology 2010;28(5):478-85.
2010: Yan Yu; Hong Jin; Daniel Holder; Josef S Ozer; Stephanie Villarreal; Paul Shughrue; Shu Shi; David J Figueroa; Holly Clouse; Ming Su; Nagaraja Muniappa; Sean P Troth; Wendy Bailey; John Seng; Amy G Aslamkhan; Douglas Thudium; Frank D Sistare; David L Gerhold
Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury.
Nature biotechnology 2010;28(5):470-7.
2010: William B Mattes; Elizabeth Gribble Walker; Eric Abadie; Frank D Sistare; Jacky Vonderscher; Janet Woodcock; Raymond L Woosley
Research at the interface of industry, academia and regulatory science.
Nature biotechnology 2010;28(5):432-3.
2010: Richard D Storer; Frank D Sistare; M Vijayaraj Reddy; Joseph J DeGeorge
An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development.
Toxicologic pathology 2010;38(1):51-61.
2009: Omar F Laterza; Lee Lim; Philip W Garrett-Engele; Katerina Vlasakova; Nagaraja Muniappa; Wesley K Tanaka; Jason M Johnson; Joseph F Sina; Thomas L Fare; Frank D Sistare; Warren E Glaab
Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury.
Clinical chemistry 2009;55(11):1977-83.
2009: Federico M Goodsaid; M Blank; F Dieterle; P Harlow; E Hausner; Frank D Sistare; A Thompson; J Vonderscher
Novel biomarkers of acute kidney toxicity.
Clinical pharmacology and therapeutics 2009;86(5):490-6.
2009: Vishal S Vaidya; Glen M Ford; Sushrut S Waikar; Yizhuo Wang; Matthew B Clement; Victoria Ramirez; Warren E Glaab; Sean P Troth; Frank D Sistare; Walter C Prozialeck; Joshua R Edwards; Norma A Bobadilla; Stephen C Mefferd; Joseph V Bonventre
A rapid urine test for early detection of kidney injury.
Kidney international 2009;76(1):108-14.
2009: Mark W Powley; Clay B Frederick; Frank D Sistare; Joseph J DeGeorge
Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.
Chemical research in toxicology 2009;22(2):257-62.
2008: James L Weaver; Ronald Snyder; Alan Knapton; Eugene H Herman; Ronald Honchel; Terry Miller; Parvaneh Espandiari; Roger Smith; Yi-Zhong Gu; Federico M Goodsaid; Irwin Y Rosenblum; Frank D Sistare; Jun Zhang; Joseph P Hanig
Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.
Toxicologic pathology 2008;36(6):840-9.
2008: Jun Zhang; Ronald D Snyder; Eugene H Herman; Alan Knapton; Ronald Honchel; Terry Miller; Parvaneh Espandiari; Federico M Goodsaid; Irwin Y Rosenblum; Joseph P Hanig; Frank D Sistare; James L Weaver
Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.
Toxicologic pathology 2008;36(6):827-39.
2008: T J Miller; Ronald Honchel; Parvaneh Espandiari; Alan Knapton; Jun Zhang; Frank D Sistare; Joseph P Hanig
The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
Regulatory toxicology and pharmacology : RTP 2008;50(1):87-97.
2008: Frank D Sistare; Joseph J Degeorge
Applications of toxicogenomics to nonclinical drug development: regulatory science considerations.
Methods in molecular biology (Clifton, N.J.) 2008;460():239-61.
2007: Ying Jiang; David Gerhold; Daniel J Holder; David Figueroa; Wendy J Bailey; Ping Guan; Thomas R Skopek; Frank D Sistare; Joseph F Sina
Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles.
Journal of translational medicine 2007;5():47.
2006: Eugene H Herman; Jun Zhang; Alan Knapton; Steven E Lipshultz; Nader Rifai; Frank D Sistare
Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats.
Cardiovascular toxicology 2006;6(3-4):211-22.
2006: Jun Zhang; Eugene H Herman; Donald G Robertson; Michael D Reily; Alan Knapton; Helen V Ratajczak; Nader Rifai; Ronald Honchel; Kerry T Blanchard; Raymond Stoll; Frank D Sistare
Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.
Toxicologic pathology 2006;34(2):152-63.
2005: Gregory S Akerman; Barry A Rosenzweig; Olen E Domon; Chen-An Tsai; Michelle E Bishop; Lynda J McGarrity; James T MacGregor; Frank D Sistare; Chun-houh Chen; Suzanne M Morris
Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells.
Environmental and molecular mutagenesis 2005;45(2-3):188-205.
2005: Karol L Thompson; Barry A Rosenzweig; P Scott Pine; Jacques Retief; Yaron Turpaz; Cynthia A Afshari; Hisham K Hamadeh; Michael A Damore; Michael Boedigheimer; Eric Blomme; Rita Ciurlionis; Jeffrey F Waring; James C Fuscoe; Richard S Paules; Charles J Tucker; Thomas Fare; Ernest M Coffey; Yudong He; Patrick J Collins; Kurt Jarnagin; Susan Fujimoto; Brigitte Ganter; Gretchen Kiser; Tamma Kaysser-Kranich; Joseph Sina; Frank D Sistare
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats.
Nucleic acids research 2005;33(22):e187.
2004: Andrew C Scallet; Larry C Schmued; William Slikker; N Grunberg; Patrick J Faustino; H Davis; D Lester; P Scott Pine; Frank D Sistare; Joseph P Hanig
Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(2):364-70.
2004: Maureen Cronin; Krishna Ghosh; Frank D Sistare; John Quackenbush; Vincent Vilker; Catherine O'Connell
Universal RNA reference materials for gene expression.
Clinical chemistry 2004;50(8):1464-71.
2004: Chun-houh Chen; Robert R Delongchamp; Chen-An Tsai; Huey-miin Hsueh; Frank D Sistare; Karol L Thompson; Varsha G Desai; James C Fuscoe
Analysis of variance components in gene expression data.
Bioinformatics (Oxford, England) 2004;20(9):1436-46.
2004: Gregory S Akerman; Barry A Rosenzweig; Olen E Domon; Lynda J McGarrity; Lonnie R Blankenship; Chen-An Tsai; Sandra J Culp; James T MacGregor; Frank D Sistare; Chun-houh Chen; Suzanne M Morris
Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.
Mutation research 2004;549(1-2):43-64.
2004: Emanuel F Petricoin; Vinodh Rajapaske; Eugene H Herman; Ali M Arekani; Sally Ross; Donald J Johann; Alan Knapton; Jun Zhang; Ben A Hitt; Thomas P Conrads; Timothy D Veenstra; Lance A Liotta; Frank D Sistare
Toxicoproteomics: serum proteomic pattern diagnostics for early detection of drug induced cardiac toxicities and cardioprotection.
Toxicologic pathology 2004;32 Suppl 1():122-30.
2004: David Jacobson-Kram; Frank D Sistare; Abigail C Jacobs
Use of transgenic mice in carcinogenicity hazard assessment.
Toxicologic pathology 2004;32 Suppl 1():49-52.
2004: Karol L Thompson; Cynthia A Afshari; Rupesh P Amin; Timothy A Bertram; Bruce Car; Michael Cunningham; Clive Kind; Jeffrey A Kramer; Michael Lawton; Michael Mirsky; Jorge M Naciff; Victor Oreffo; P Scott Pine; Frank D Sistare
Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.
Environmental health perspectives 2004;112(4):488-94.
2004: Barry A Rosenzweig; P Scott Pine; Olen E Domon; Suzanne M Morris; Chun-houh Chen; Frank D Sistare
Dye bias correction in dual-labeled cDNA microarray gene expression measurements.
Environmental health perspectives 2004;112(4):480-7.
2004: Rupesh P Amin; Alison E Vickers; Frank D Sistare; Karol L Thompson; Richard J Roman; Michael Lawton; Jeffrey Kramer; Hisham K Hamadeh; Jennifer Collins; Sherry F Grissom; Lee Bennett; Charles J Tucker; Stacie Wild; Clive Kind; Victor Oreffo; John W Davis; Sandra W Curtiss; Jorge M Naciff; Michael Cunningham; Raymond W Tennant; James Stevens; Bruce Car; Timothy A Bertram; Cynthia A Afshari
Identification of putative gene based markers of renal toxicity.
Environmental health perspectives 2004;112(4):465-79.
2004: Jeffrey A Kramer; syril director pettit; Rupesh P Amin; Timothy A Bertram; Bruce Car; Michael Cunningham; Sandra W Curtiss; John W Davis; Clive Kind; Michael Lawton; Jorge M Naciff; Victor Oreffo; Richard J Roman; Frank D Sistare; James Stevens; Karol Thompson; Alison E Vickers; Stacey Wild; Cynthia A Afshari
Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment.
Environmental health perspectives 2004;112(4):460-4.
2004: James MacDonald; John E French; Ronald J Gerson; Jay Goodman; Tohru Inoue; Abigail Jacobs; Peter Kasper; Douglas Keller; Amy Lavin; Gerald Long; Bruce McCullough; Frank D Sistare; Richard D Storer; Jan Willem van der Laan
The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):188-94.
2004: Kendall B Wallace; Elizabeth Hausner; Eugene H Herman; Gordon D Holt; James T MacGregor; Alan L Metz; Elizabeth Murphy; I Y Rosenblum; Frank D Sistare; Malcolm J York
Serum troponins as biomarkers of drug-induced cardiac toxicity.
Toxicologic pathology 2004;32(1):106-21.
2003: Richard D Storer; John E French; Lawrence A Donehower; D Gulezian; K Mitsumori; Leslie Recio; R H Schiestl; Frank D Sistare; N Tamaoki; T Usui; H van Steeg
Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines.
Mutation research 2003;540(2):165-76.
2003: Karol L Thompson; Barry A Rosenzweig; James L Weaver; Jun Zhang; Karl K Lin; Frank D Sistare
Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):271-8.
2003: Karol L Thompson; Frank D Sistare
Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):260-70.
2003: Lawrence J Lesko; Ronald A Salerno; Brian B Spear; Donald C Anderson; Timothy Anderson; Celia Brazell; Jerry Collins; Andrew Dorner; David Essayan; Baltazar Gomez-Mancilla; Joseph Hackett; Shiew-Mei Huang; Susan Ide; Joanne Killinger; John Leighton; Elizabeth Mansfield; Robert Meyer; Stephen G Ryan; Virginia Schmith; Peter Shaw; Frank D Sistare; Mark Watson; Alexandra Worobec
Pharmacogenetics and pharmacogenomics in drug development and regulatory decision making: report of the first FDA-PWG-PhRMA-DruSafe Workshop.
Journal of clinical pharmacology 2003;43(4):342-58.
2003: Yi-Ju Chen; Ralph L Kodell; Frank D Sistare; Karol L Thompson; Suzanne Morris; Chun-houh Chen
Normalization methods for analysis of microarray gene-expression data.
Journal of biopharmaceutical statistics 2003;13(1):57-74.
2002: Emanuel F Petricoin; Joseph L Hackett; Lawrence J Lesko; Raj K Puri; Steven I Gutman; Konstantin Chumakov; Janet Woodcock; David W Feigal; Kathy Zoon; Frank D Sistare
Medical applications of microarray technologies: a regulatory science perspective.
Nature genetics 2002;32 Suppl():474-9.
2002: Kathleen A Haberny; Merle Paule; Andrew C Scallet; Frank D Sistare; David Lester; Joseph P Hanig; William Slikker
Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):9-17.
2002: Frank D Sistare; Karol L Thompson; Ronald Honchel; Joseph DeGeorge
Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals--practical pointers, mechanistic clues, and new questions.
International journal of toxicology 2002;21(1):65-79.
2002: Jun Zhang; Eugene H Herman; Alan Knapton; Douglas P Chadwick; Virgil E Whitehurst; John E Koerner; Thomas Papoian; Victor J Ferrans; Frank D Sistare
SK&F 95654-induced acute cardiovascular toxicity in Sprague-Dawley rats--histopathologic, electron microscopic, and immunohistochemical studies.
Toxicologic pathology 2002;30(1):28-40.
2001: Karol L Thompson; Barry A Rosenzweig; Ronald Honchel; R E Cannon; Kerry T Blanchard; Raymond Stoll; Frank D Sistare
Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.
Molecular carcinogenesis 2001;32(4):176-86.
2001: Ronald Honchel; Barry A Rosenzweig; Karol L Thompson; Kerry T Blanchard; SM Furst; Raymond Stoll; Frank D Sistare
Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype.
Molecular carcinogenesis 2001;30(2):99-110.
2001: Frank D Sistare
Transgenic animal models that might be useful in identifying unsuspected oncogenic factors in tumour cell substrates.
Developments in biologicals 2001;106():123-31; discussion 131-2, 143-60.
2001: Eugene H Herman; J A Vick; John M Strong; Robert J Parker; H M Geyer; E D Kramer; K M Higgins; Frank D Sistare
Cardiovascular effects of buccal exposure to dermal nicotine patches in the dog: a comparative evaluation.
Journal of toxicology. Clinical toxicology 2001;39(2):135-42.
2000: Karol L Thompson; Barry A Rosenzweig; Y Tsong; Frank D Sistare
Evaluation of in vitro reporter gene induction assays for use in a rapid prescreen for compound selection to test specificity in the Tg.AC mouse short-term carcinogenicity assay.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):43-53.
1998: Karol L Thompson; Barry A Rosenzweig; Frank D Sistare
An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.
Toxicologic pathology 1998;26(4):548-55.
1998: James L Weaver; Joseph F Contrera; Barry A Rosenzweig; Karol L Thompson; Patrick J Faustino; John M Strong; Christopher D Ellison; Lawrence W Anderson; H R Prasanna; P E Long-Bradley; K K Lin; Jun Zhang; Frank D Sistare
An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype.
Toxicologic pathology 1998;26(4):532-40.
1995: Frank D Sistare; B A Rosenzweig; J G Contrera
P2 purinergic receptors potentiate parathyroid hormone receptor-mediated increases in intracellular calcium and inositol trisphosphate in UMR-106 rat osteoblasts.
Endocrinology 1995;136(10):4489-97.
1994: Frank D Sistare; B A Rosenzweig; J G Contrera; B Jordan
Separate P2T and P2U purinergic receptors with similar second messenger signaling pathways in UMR-106 osteoblasts.
The Journal of pharmacology and experimental therapeutics 1994;269(3):1049-61.
1994: A J Murgo; J G Contrera; Frank D Sistare
Evidence for separate calcium-signaling P2T and P2U purinoceptors in human megakaryocytic Dami cells.
Blood 1994;83(5):1258-67.
1992: A J Murgo; Frank D Sistare
K562 leukemia cells express P2T (adenosine diphosphate) purinergic receptors.
The Journal of pharmacology and experimental therapeutics 1992;261(2):580-5.