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Lea Sistonen

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Maria Sundvall; Katri Vaparanta; Julius Anckar; Rami I Aqeilan; Kalle Halkilahti; Anna Korhonen; Jorma J Palvimo; Zaidoun Salah; Lea Sistonen; Klaus Elenius
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.
Julius Anckar; Lea Sistonen
Regulation of HSF1 function in the heat stress response: implications in aging and disease.
Johanna K Ahlskog; Johanna K Björk; Alexandra N Elsing; Camilla Aspelin; Marko Kallio; Pia Roos-Mattjus; Lea Sistonen
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.

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All Publications

2012: Maria Sundvall; Katri Vaparanta; Julius Anckar; Rami I Aqeilan; Kalle Halkilahti; Anna Korhonen; Jorma J Palvimo; Zaidoun Salah; Lea Sistonen; Klaus Elenius
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.
The Journal of biological chemistry 2012;287(27):23216-26.
2011: Julius Anckar; Lea Sistonen
Regulation of HSF1 function in the heat stress response: implications in aging and disease.
Annual review of biochemistry 2011;80():1089-115.
2010: Johanna K Ahlskog; Johanna K Björk; Alexandra N Elsing; Camilla Aspelin; Marko Kallio; Pia Roos-Mattjus; Lea Sistonen
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.
Molecular and cellular biology 2010;30(24):5608-20.
2010: Malin Akerfelt; Anniina Vihervaara; Asta Laiho; Annie Conter; Elisabeth S Christians; Lea Sistonen; Eva Henriksson
Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression.
The Journal of biological chemistry 2010;285(45):34469-76.
2010: Johanna K Björk; Lea Sistonen
Regulation of the members of the mammalian heat shock factor family.
The FEBS journal 2010;277(20):4126-39.
2010: Johanna K Björk; Anton Sandqvist; Alexandra N Elsing; Noora Kotaja; Lea Sistonen
miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis.
Development (Cambridge, England) 2010;137(19):3177-84.
2010: Malin Akerfelt; Richard I Morimoto; Lea Sistonen
Heat shock factors: integrators of cell stress, development and lifespan.
Nature reviews. Molecular cell biology 2010;11(8):545-55.
2010: Henri A Blomster; Susumu Imanishi; Jenny Siimes; Juha Kastu; Nick A Morrice; John E Eriksson; Lea Sistonen
In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
The Journal of biological chemistry 2010;285(25):19324-9.
2009: Kristiina A M Vuori; Johanna K Ahlskog; Lea Sistonen; Mikko Nikinmaa
TransLISA, a novel quantitative, nonradioactive assay for transcription factor DNA-binding analyses.
The FEBS journal 2009;276(24):7366-74.
2009: Henri A Blomster; Ville Hietakangas; Jianmin Wu; Petri Kouvonen; Sampsa Hautaniemi; Lea Sistonen
Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites.
Molecular & cellular proteomics : MCP 2009;8(6):1382-90.
2009: Aïcha Metchat; Malin Akerfelt; Christiane Bierkamp; Virginie Delsinne; Lea Sistonen; Henri Alexandre; Elisabeth S Christians
Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression.
The Journal of biological chemistry 2009;284(14):9521-8.
2009: Anton Sandqvist; Johanna K Björk; Malin Akerfelt; Zhanna Chitikova; Alexei Grichine; Claire VOURC'H; Caroline Jolly; Tiina A Salminen; Yvonne Nymalm; Lea Sistonen
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.
Molecular biology of the cell 2009;20(5):1340-7.
2009: Sandy Westerheide; Julius Anckar; Stanley M Stevens; Lea Sistonen; Richard I Morimoto
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
Science (New York, N.Y.) 2009;323(5917):1063-6.
2008: Malin Akerfelt; Eva Henriksson; Asta Laiho; Anniina Vihervaara; Karoliina Rautoma; Noora Kotaja; Lea Sistonen
Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11224-9.
2007: Julius Anckar; Lea Sistonen
SUMO: getting it on.
Biochemical Society transactions 2007;35(Pt 6):1409-13.
2007: Malin Akerfelt; Diane Trouillet; Valérie Mezger; Lea Sistonen
Heat shock factors at a crossroad between stress and development.
Annals of the New York Academy of Sciences 2007;1113():15-27.
2007: Anna S Sahlberg; Markus A Penttinen; Kaisa M Heiskanen; Robert A Colbert; Lea Sistonen; Kaisa Granfors
Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells: correlation with HLA-B27 misfolding.
Arthritis and rheumatism 2007;56(8):2652-62.
2007: Eniko Nagy; Zsolt Balogi; Imre Gombos; Malin Akerfelt; Anders Björkbom; Gábor Balogh; Zsolt Török; Andriy Maslyanko; Anna Fiszer-Kierzkowska; Katarzyna Lisowska; Peter J Slotte; Lea Sistonen; Ibolya Horváth; László Vígh
Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7945-50.
2007: Annika Meinander; Thomas S Söderström; Aura Kaunisto; Minna Poukkula; Lea Sistonen; John E Eriksson
Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3944-53.
2007: Päivi Ostling; Johanna K Björk; Pia Roos-Mattjus; Valérie Mezger; Lea Sistonen
Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1.
The Journal of biological chemistry 2007;282(10):7077-86.
2007: Julius Anckar; Lea Sistonen
Heat shock factor 1 as a coordinator of stress and developmental pathways.
Advances in experimental medicine and biology 2007;594():78-88.
2006: Yunhua Chang; Päivi Ostling; Malin Akerfelt; Diane Trouillet; Murielle Rallu; Yorick Gitton; Rachid El Fatimy; Vivienne Fardeau; Stéphane Le Crom; Michel Morange; Lea Sistonen; Valérie Mezger
Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.
Genes & development 2006;20(7):836-47.
2006: Johanna K Björk; Lea Sistonen
Clustering of heat-shock factors.
The Biochemical journal 2006;395(1):e5-6.
2006: Julius Anckar; Ville Hietakangas; Konstantin Denessiouk; Dennis J Thiele; Mark S Johnson; Lea Sistonen
Inhibition of DNA binding by differential sumoylation of heat shock factors.
Molecular and cellular biology 2006;26(3):955-64.
2006: Ville Hietakangas; Julius Anckar; Henri A Blomster; Mitsuaki Fujimoto; Jorma J Palvimo; Akira Nakai; Lea Sistonen
PDSM, a motif for phosphorylation-dependent SUMO modification.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):45-50.
2005: Minna Poukkula; Aura Kaunisto; Ville Hietakangas; Konstantin Denessiouk; Tuire Katajamäki; Mark S Johnson; Lea Sistonen; John E Eriksson
Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail.
The Journal of biological chemistry 2005;280(29):27345-55.
2005: Caoimhín G Concannon; Una FitzGerald; Carina I Holmberg; Eva Szegezdi; Lea Sistonen; Afshin Samali
CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.
Cell stress & chaperones 2005;10(1):59-65.
2004: Markus A Penttinen; Kaisa M Heiskanen; Rajashree Mohapatra; Monica L DeLay; Robert A Colbert; Lea Sistonen; Kaisa Granfors
Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27.
Arthritis and rheumatism 2004;50(7):2255-63.
2004: Anton Sandqvist; Lea Sistonen
Nuclear stress granules: the awakening of a sleeping beauty?
The Journal of cell biology 2004;164(1):15-7.
2004: Pia Roos-Mattjus; Lea Sistonen
The ubiquitin-proteasome pathway.
Annals of medicine 2004;36(4):285-95.
2003: S E F Tran; Annika Meinander; Tim H Holmström; Adolfo Rivero-Muller; Kaisa M Heiskanen; E K Linnau; Michael J Courtney; D D Mosser; Lea Sistonen; John E Eriksson
Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis.
Cell death and differentiation 2003;10(10):1137-47.
2003: Tero-Pekka Alastalo; Maria Hellesuo; Anton Sandqvist; Ville Hietakangas; Marko Kallio; Lea Sistonen
Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70.
Journal of cell science 2003;116(Pt 17):3557-70.
2003: Susanna Airaksinen; Christina M I Råbergh; Anna Lahti; Annukka Kaatrasalo; Lea Sistonen; Mikko Nikinmaa
Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2003;134(4):839-46.
2003: Ville Hietakangas; Johanna K Ahlskog; Annika M Jakobsson; Maria Hellesuo; Niko M Sahlberg; Carina I Holmberg; Andrey Mikhailov; Jorma J Palvimo; Lila Pirkkala; Lea Sistonen
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.
Molecular and cellular biology 2003;23(8):2953-68.
2003: Ville Hietakangas; Minna Poukkula; Kaisa M Heiskanen; Jarkko T Karvinen; Lea Sistonen; John E Eriksson
Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.
Molecular and cellular biology 2003;23(4):1278-91.
2002: Carina I Holmberg; Stefanie E F Tran; John E Eriksson; Lea Sistonen
Multisite phosphorylation provides sophisticated regulation of transcription factors.
Trends in biochemical sciences 2002;27(12):619-27.
2002: Niku K J Oksala; Kai Kaarniranta; Jyrki J Tenhunen; R Tiihonen; Antero Heino; Lea Sistonen; Hannu Paimela; Esko Alhava
Reperfusion but not acute ischemia in pig small intestine induces transcriptionally mediated heat shock response in situ.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2002;34(6):397-404.
2002: Markus A Penttinen; Carina I Holmberg; Lea Sistonen; Kaisa Granfors
HLA-B27 modulates nuclear factor kappaB activation in human monocytic cells exposed to lipopolysaccharide.
Arthritis and rheumatism 2002;46(8):2172-80.
2002: Marko Kallio; Yunhua Chang; Michaël Manuel; Tero-Pekka Alastalo; Murielle Rallu; Yorick Gitton; Lila Pirkkala; Marie-Thérèse Loones; Liliana Paslaru; Severine Larney; Sophie Hiard; Michel Morange; Lea Sistonen; Valérie Mezger
Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice.
The EMBO journal 2002;21(11):2591-601.
2002: Kai Kaarniranta; Niku K J Oksala; Hannu M Karjalainen; Tiina Suuronen; Lea Sistonen; Heikki J Helminen; Antero Salminen; Mikko Juhani Lammi
Neuronal cells show regulatory differences in the hsp70 gene response.
Brain research. Molecular brain research 2002;101(1-2):136-40.
2001: P Nykänen; Tero-Pekka Alastalo; J Ahlskog; N Horelli-Kuitunen; Lila Pirkkala; Lea Sistonen
Genomic organization and promoter analysis of the human heat shock factor 2 gene.
Cell stress & chaperones 2001;6(4):377-85.
2001: Ville Hietakangas; I Elo; H Rosenström; Eleanor T Coffey; John Kyriakis; John E Eriksson; Lea Sistonen
Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform.
FEBS letters 2001;505(1):168-72.
2001: Sirpa Leppä; Risto Kajanne; L Arminen; Lea Sistonen
Differential induction of Hsp70-encoding genes in human hematopoietic cells.
The Journal of biological chemistry 2001;276(34):31713-9.
2001: Carina I Holmberg; Ville Hietakangas; Andrey Mikhailov; J O Rantanen; Marko Kallio; Annika Meinander; Jukka Hellman; N Morrice; C MacKintosh; R I Morimoto; John E Eriksson; Lea Sistonen
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.
The EMBO journal 2001;20(14):3800-10.
2001: Arto Soitamo; C M Rabergh; Max Gassmann; Lea Sistonen; Mikko Nikinmaa
Characterization of a hypoxia-inducible factor (HIF-1alpha ) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension.
The Journal of biological chemistry 2001;276(23):19699-705.
2001: Lila Pirkkala; P Nykänen; Lea Sistonen
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(7):1118-31.
2001: Kai Kaarniranta; Niku K J Oksala; Mikko Juhani Lammi; Heikki J Helminen; Lea Sistonen
[From research of cellular stress to various clinical break through innovations?].
Duodecim; lääketieteellinen aikakauskirja 2001;117(22):2266-72.
2001: Kai Kaarniranta; C I Holmberg; Mikko Juhani Lammi; John E Eriksson; Lea Sistonen; Heikki J Helminen
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):7-13.
2000: M Eriksson; Eero Jokinen; Lea Sistonen; Sirpa Leppä
Heat shock factor 2 is activated during mouse heart development.
The International journal of developmental biology 2000;44(5):471-7.
2000: Carina I Holmberg; S A Illman; Marko Kallio; Andrey Mikhailov; Lea Sistonen
Formation of nuclear HSF1 granules varies depending on stress stimuli.
Cell stress & chaperones 2000;5(3):219-28.
2000: Kai Kaarniranta; C I Holmberg; Heikki J Helminen; John E Eriksson; Lea Sistonen; Mikko Juhani Lammi
Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature.
FEBS letters 2000;475(3):283-6.
2000: Christina M I Råbergh; Susanna Airaksinen; Arto Soitamo; Harry Björklund; T Johansson; Mikko Nikinmaa; Lea Sistonen
Tissue-specific expression of zebrafish (Danio rerio) heat shock factor 1 mRNAs in response to heat stress.
The Journal of experimental biology 2000;203(Pt 12):1817-24.
2000: Lila Pirkkala; Tero-Pekka Alastalo; XiaoXia Zuo; Ivor J Benjamin; Lea Sistonen
Disruption of heat shock factor 1 reveals an essential role in the ubiquitin proteolytic pathway.
Molecular and cellular biology 2000;20(8):2670-5.
1999: Lila Pirkkala; Lea Sistonen
Antibody supershift assay is inadequate for determining HSF stoichiometry in HSE complexes.
Cell stress & chaperones 1999;4(4):259-61.
1999: Afshin Samali; C I Holmberg; Lea Sistonen; Sten Orrenius
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins.
FEBS letters 1999;461(3):306-10.
1999: Lila Pirkkala; Tero-Pekka Alastalo; P Nykanen; L Seppa; Lea Sistonen
Differentiation lineage-specific expression of human heat shock transcription factor 2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(9):1089-98.
1998: Carina I Holmberg; P M Roos; J M Lord; John E Eriksson; Lea Sistonen
Conventional and novel PKC isoenzymes modify the heat-induced stress response but are not activated by heat shock.
Journal of cell science 1998;111 ( Pt 22)():3357-65.
1998: Susanna Airaksinen; Christina M I Råbergh; Lea Sistonen; Mikko Nikinmaa
Effects of heat shock and hypoxia on protein synthesis in rainbow trout (Oncorhynchus mykiss) cells.
The Journal of experimental biology 1998;201(Pt 17):2543-51.
1998: Tero-Pekka Alastalo; M Lönnström; Sirpa Leppä; Kai Kaarniranta; Markku Pelto-Huikko; Lea Sistonen; Martti Parvinen
Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium.
Experimental cell research 1998;240(1):16-27.
1998: Tim H Holmström; Sek C Chow; I Elo; Eleanor T Coffey; S Orrenius; Lea Sistonen; John E Eriksson
Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2626-36.
1998: Kai Kaarniranta; Mika A Elo; Reijo K Sironen; Mikko Juhani Lammi; M B Goldring; John E Eriksson; Lea Sistonen; Heikki J Helminen
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2319-24.
1997: Sirpa Leppä; Lila Pirkkala; S C Chow; John E Eriksson; Lea Sistonen
Thioredoxin is transcriptionally induced upon activation of heat shock factor 2.
The Journal of biological chemistry 1997;272(48):30400-4.
1997: Sirpa Leppä; Lila Pirkkala; H Saarento; K D Sarge; Lea Sistonen
Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
The Journal of biological chemistry 1997;272(24):15293-8.
1997: Carina I Holmberg; Sirpa Leppä; John E Eriksson; Lea Sistonen
The phorbol ester 12-O-tetradecanoylphorbol 13-acetate enhances the heat-induced stress response.
The Journal of biological chemistry 1997;272(10):6792-8.
1997: Sirpa Leppä; Lea Sistonen
Heat shock response--pathophysiological implications.
Annals of medicine 1997;29(1):73-8.
1994: S K Mathur; Lea Sistonen; I R Brown; S P Murphy; Kevin D Sarge; Richard I Morimoto
Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8695-9.
1994: Donald A Jurivich; Lea Sistonen; Kevin D Sarge; Richard I Morimoto
Arachidonate is a potent modulator of human heat shock gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2280-4.
1994: Lea Sistonen; Kevin D Sarge; Richard I Morimoto
Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.
Molecular and cellular biology 1994;14(3):2087-99.
1992: Lea Sistonen; Kevin D Sarge; B Phillips; K Abravaya; Richard I Morimoto
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.
Molecular and cellular biology 1992;12(9):4104-11.
1992: Donald A Jurivich; Lea Sistonen; Roger Kroes; Richard I Morimoto
Effect of sodium salicylate on the human heat shock response.
Science (New York, N.Y.) 1992;255(5049):1243-5.