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Roberto Sitia
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23
Rubartelli, Anna
12
Fagioli, Claudio
11
Fra, Anna
11
Cabibbo, A
8
Mezghrani, Alexandre
7
Pasqualetto, Elena
7
Anelli, Tiziana
6
Fassio, Anna
5
Simmen, Thomas
5
Bertoli, Gloria
5
Alessio, Massimo
4
Braakman, Ineke
4
Consalez, Giacomo
4
Stavnezer, Janet
4
Ruffato, Elena
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All Publications
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2009: Bianchi Giada; Oliva Laura; Cascio Paolo; Pengo Niccolò; Fontana Francesca; Cerruti Fulvia; Orsi Andrea; Pasqualetto Elena; Mezghrani Alexandre; Calbi Valeria; Palladini Giovanni; Giuliani Nicola; Anderson Kenneth C; Sitia Roberto; Cenci Simone
The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.
Blood 2009;113(13):3040-9.
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2008: Cenci Simone; Pengo Niccolò; Sitia Roberto
Proteotoxic stress and cell lifespan control.
Molecules and cells 2008;26(4):323-8.
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2008: Fraldi Alessandro; Zito Ester; Annunziata Fabio; Lombardi Alessia; Cozzolino Marianna; Monti Maria; Spampanato Carmine; Ballabio Andrea; Pucci Piero; Sitia Roberto; Cosma Maria Pia
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.
Human molecular genetics 2008;17(17):2610-21.
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2008: Wang Likun; Wang Lei; Vavassori Stefano; Li Shengjian; Ke Huimin; Anelli Tiziana; Degano Massimo; Ronzoni Riccardo; Sitia Roberto; Sun Fei; Wang Chih-Chen
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail.
EMBO reports 2008;9(7):642-7.
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2008: Cattaneo Monica; Otsu Mieko; Fagioli Claudio; Martino Simone; Lotti Lavinia Vittoria; Sitia Roberto; Biunno Ida
SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains.
Journal of cellular physiology 2008;215(3):794-802.
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2008: Nerini-Molteni Silvia; Ferrarini Marina; Cozza Sara; Caligaris-Cappio Federico; Sitia Roberto
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib.
British journal of haematology 2008;141(4):494-503.
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2008: Masciarelli Silvia; Sitia Roberto
Building and operating an antibody factory: redox control during B to plasma cell terminal differentiation.
Biochimica et biophysica acta 2008;1783(4):578-88.
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2008: Cascio Paolo; Oliva Laura; Cerruti Fulvia; Mariani Elisabetta; Pasqualetto Elena; Cenci Simone; Sitia Roberto
Dampening Ab responses using proteasome inhibitors following in vivo B cell activation.
European journal of immunology 2008;38(3):658-67.
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2008: Anelli Tiziana; Sitia Roberto
Protein quality control in the early secretory pathway.
The EMBO journal 2008;27(2):315-27.
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2007: Orsi Andrea; Sitia Roberto
Interplays between covalent modifications in the endoplasmic reticulum increase conformational diversity in nascent prion protein.
Prion 2007;1(4):236-42.
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2007: Sitia Roberto; Palladini Giovanni; Merlini Giampaolo
Bortezomib in the treatment of AL amyloidosis: targeted therapy?
Haematologica 2007;92(10):1302-7.
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2007: Anelli Tiziana; Ceppi Stefania; Bergamelli Leda; Cortini Margherita; Masciarelli Silvia; Valetti Caterina; Sitia Roberto
Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis.
The EMBO journal 2007;26(19):4177-88.
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2007: Bánhegyi Gábor; Baumeister Peter; Benedetti Angelo; Dong Dezheng; Fu Yong; Lee Amy S; Li Jianze; Mao Changhui; Margittai Eva; Ni Min; Paschen Wulf; Piccirella Simona; Senesi Silvia; Sitia Roberto; Wang Miao; Yang Wei
Endoplasmic reticulum stress.
Annals of the New York Academy of Sciences 2007;1113():58-71.
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2007: Cenci Simone; Sitia Roberto
Managing and exploiting stress in the antibody factory.
FEBS letters 2007;581(19):3652-7.
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2007: Otsu Mieko; Sitia Roberto
Diseases originating from altered protein quality control in the endoplasmic reticulum.
Current medicinal chemistry 2007;14(15):1639-52.
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2006: Orsi Andrea; Fioriti Luana; Chiesa Roberto; Sitia Roberto
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein.
The Journal of biological chemistry 2006;281(41):30431-8.
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2006: Mattioli Laura; Anelli Tiziana; Fagioli Claudio; Tacchetti Carlo; Sitia Roberto; Valetti Caterina
ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies.
Journal of cell science 2006;119(Pt 12):2532-41.
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2006: Otsu Mieko; Bertoli Gloria; Fagioli Claudio; Guerini-Rocco Elena; Nerini-Molteni Silvia; Ruffato Elena; Sitia Roberto
Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.
Antioxidants & redox signaling 2006;8(3-4):274-82.
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2006: Benham Adam M; Sitia Roberto
The diversity of oxidative protein folding.
Antioxidants & redox signaling 2006;8(3-4):271-3.
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2006: Cenci Simone; Mezghrani Alexandre; Cascio Paolo; Bianchi Giada; Cerruti Fulvia; Fra Anna; Lelouard Hugues; Masciarelli Silvia; Mattioli Laura; Oliva Laura; Orsi Andrea; Pasqualetto Elena; Pierre Philippe; Ruffato Elena; Tagliavacca Luigina; Sitia Roberto
Progressively impaired proteasomal capacity during terminal plasma cell differentiation.
The EMBO journal 2006;25(5):1104-13.
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2004: Molteni Silvia Nerini; Fassio Anna; Ciriolo Maria Rosa; Filomeni Giuseppe; Pasqualetto Elena; Fagioli Claudio; Sitia Roberto
Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.
The Journal of biological chemistry 2004;279(31):32667-73.
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2004: Bertoli Gloria; Simmen Thomas; Anelli Tiziana; Molteni Silvia Nerini; Fesce Riccardo; Sitia Roberto
Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum.
The Journal of biological chemistry 2004;279(29):30047-52.
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2004: Sitia Roberto; Molteni Silvia Nerini
Stress, protein (mis)folding, and signaling: the redox connection.
Science's STKE : signal transduction knowledge environment 2004;2004(239):pe27.
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2004: Piccini Alessandra; Fassio Anna; Pasqualetto Elena; Vitali Antonella; Borghi Roberta; Palmieri Daniela; Nacmias Benedetta; Sorbi Sandro; Sitia Roberto; Tabaton Massimo
Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin.
Neurobiology of disease 2004;15(2):380-6.
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2003: Sitia Roberto; Braakman Ineke
Quality control in the endoplasmic reticulum protein factory.
Nature 2003;426(6968):891-4.
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2003: Anelli Tiziana; Alessio Massimo; Bachi Angela; Bergamelli Leda; Bertoli Gloria; Camerini Serena; Mezghrani Alexandre; Ruffato Elena; Simmen Thomas; Sitia Roberto
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.
The EMBO journal 2003;22(19):5015-22.
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2003: Tagliavacca Luigina; Anelli Tiziana; Fagioli Claudio; Mezghrani Alexandre; Ruffato Elena; Sitia Roberto
The making of a professional secretory cell: architectural and functional changes in the ER during B lymphocyte plasma cell differentiation.
Biological chemistry 2003;384(9):1273-7.
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2003: van Anken Eelco; Romijn Edwin P; Maggioni Claudia; Mezghrani Alexandre; Sitia Roberto; Braakman Ineke; Heck Albert J R
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion.
Immunity 2003;18(2):243-53.
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2003: Cunnea Paula M; Miranda-Vizuete Antonio; Bertoli Gloria; Simmen Thomas; Damdimopoulos Anastasios E; Hermann Stefan; Leinonen Saku; Huikko Markku Pelto; Gustafsson Jan-Ake; Sitia Roberto; Spyrou Giannis
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
The Journal of biological chemistry 2003;278(2):1059-66.
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2002: Fassio Anna; Sitia Roberto
Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum.
Histochemistry and cell biology 2002;117(2):151-7.
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2002: Anelli Tiziana; Alessio Massimo; Mezghrani Alexandre; Simmen Thomas; Talamo Fabio; Bachi Angela; Sitia Roberto
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family.
The EMBO journal 2002;21(4):835-44.
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2002: Angelini Giovanna; Gardella Stefania; Ardy Massimo; Ciriolo Maria Rosa; Filomeni Giuseppe; Di Trapani Giovanna; Clarke Frank; Sitia Roberto; Rubartelli Anna
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1491-6.
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2001: Mezghrani A; Fassio A; Benham A; Simmen T; Braakman I; Sitia R
Manipulation of oxidative protein folding and PDI redox state in mammalian cells.
The EMBO journal 2001;20(22):6288-96.
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2001: Pagani M; Pilati S; Bertoli G; Valsasina B; Sitia R
The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function.
FEBS letters 2001;508(1):117-20.
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2001: Fagioli C; Mezghrani A; Sitia R
Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation.
The Journal of biological chemistry 2001;276(44):40962-7.
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2001: Navone F; Consalez G G; Sardella M; Caspani E; Pozzoli O; Frassoni C; Morlacchi E; Sitia R; Sprocati T; Cabibbo A
Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.
Journal of neurochemistry 2001;77(3):741-53.
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2001: Fagioli C; Sitia R
Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits.
The Journal of biological chemistry 2001;276(16):12885-92.
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2000: Benedetti C; Fabbri M; Sitia R; Cabibbo A
Aspects of gene regulation during the UPR in human cells.
Biochemical and biophysical research communications 2000;278(3):530-6.
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2000: Benham A M; Cabibbo A; Fassio A; Bulleid N; Sitia R; Braakman I
The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha.
The EMBO journal 2000;19(17):4493-502.
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2000: Gruarin P; Thorne R F; Dorahy D J; Burns G F; Sitia R; Alessio M
CD36 is a ditopic glycoprotein with the N-terminal domain implicated in intracellular transport.
Biochemical and biophysical research communications 2000;275(2):446-54.
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2000: Pagani M; Fabbri M; Benedetti C; Fassio A; Pilati S; Bulleid N J; Cabibbo A; Sitia R
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response.
The Journal of biological chemistry 2000;275(31):23685-92.
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2000: Mancini R; Fagioli C; Fra A M; Maggioni C; Sitia R
Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled events.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):769-78.
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2000: Fra A M; Pasqualetto E; Mancini M; Sitia R
Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2.
Gene 2000;243(1-2):75-83.
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2000: Cabibbo A; Pagani M; Fabbri M; Rocchi M; Farmery M R; Bulleid N J; Sitia R
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum.
The Journal of biological chemistry 2000;275(7):4827-33.
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1999: Fra A M; Mastroianni N; Mancini M; Pasqualetto E; Sitia R
Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors.
Genomics 1999;56(3):355-6.
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1999: Consalez G G; Cabibbo A; Corradi A; Alli C; Sardella M; Sitia R; Fesce R
A computer-driven approach to PCR-based differential screening, alternative to differential display.
Bioinformatics (Oxford, England) 1999;15(2):93-105.
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1998: Rubartelli A; Poggi A; Sitia R; Zocchi M R
HIV-I Tat: a polypeptide for all seasons.
Immunology today 1998;19(12):543-5.
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1998: de Lalla C; Fagioli C; Cessi F S; Smilovich D; Sitia R
Biogenesis and function of IgM: the role of the conserved mu-chain tailpiece glycans.
Molecular immunology 1998;35(13):837-45.
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1998: Maggioni C; Carelli S; Cabibbo A; Fagioli C; Fra A M; Sitia R
Assembly and secretion of antibodies during B cell development.
Bratislavské lekárske listy 1998;99(8-9):419-25.
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1998: Smilovich D; Malagolini N; Fagioli C; de Lalla C; Sitia R; Serafini-Cessi F
Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase.
Glycobiology 1998;8(8):841-8.
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1998: Cabibbo A; Consalez G G; Sardella M; Sitia R; Rubartelli A
Changes in gene expression during the growth arrest of HepG2 hepatoma cells induced by reducing agents or TGFbeta1.
Oncogene 1998;16(22):2935-43.
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1998: Sitia R; Ceriotti A; Cabibbo A; Fassina G; Ruvo M
Secretion of thiols and disulfide bond formation: retraction.
Science (New York, N.Y.) 1998;279(5355):1288-9.
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1998: Sardella M; Navone F; Rocchi M; Rubartelli A; Viggiano L; Vignali G; Consalez G G; Sitia R; Cabibbo A
KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23.
Genomics 1998;47(3):405-8.
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1997: Gruarin P; Sitia R; Alessio M
Formation of one or more intrachain disulphide bonds is required for the intracellular processing and transport of CD36.
The Biochemical journal 1997;328 ( Pt 2)():635-42.
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1997: Carelli S; Ceriotti A; Cabibbo A; Fassina G; Ruvo M; Sitia R
Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.
Science (New York, N.Y.) 1997;277(5332):1681-4.
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1997: Carelli S; Ceriotti A; Sitia R
Stringent thiol-mediated retention in B lymphocytes and Xenopus oocytes correlates with inefficient IgM polymerization.
European journal of immunology 1997;27(5):1283-91.
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1997: Morgavi P; Bonifaci N; Pagani M; Costigliolo S; Sitia R; Rubartelli A
The association of HIV-1 Tat with nuclei is regulated by Ca2+ ions and cytosolic factors.
The Journal of biological chemistry 1997;272(17):11256-60.
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1996: Isidoro C; Maggioni C; Demoz M; Pizzagalli A; Fra A M; Sitia R
Exposed thiols confer localization in the endoplasmic reticulum by retention rather than retrieval.
The Journal of biological chemistry 1996;271(42):26138-42.
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1996: Reddy P; Sparvoli A; Fagioli C; Fassina G; Sitia R
Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig light chains.
The EMBO journal 1996;15(9):2077-85.
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1996: Cals M M; Guenzi S; Carelli S; Simmen T; Sparvoli A; Sitia R
IgM polymerization inhibits the Golgi-mediated processing of the mu-chain carboxy-terminal glycans.
Molecular immunology 1996;33(1):15-24.
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1996: Alessio M; De Monte L; Scirea A; Gruarin P; Tandon N N; Sitia R
Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation.
The Journal of biological chemistry 1996;271(3):1770-5.
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1995: Rubartelli A; Sitia R
Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations.
Trends in cell biology 1995;5(11):409-12.
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1995: Bonifaci N; Sitia R; Rubartelli A
Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding.
AIDS (London, England) 1995;9(9):995-1000.
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1995: Rubartelli A; Bonifaci N; Sitia R
High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells.
Cancer research 1995;55(3):675-80.
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1994: Valetti C; Sitia R
The differential effects of dithiothreitol and 2-mercaptoethanol on the secretion of partially and completely assembled immunoglobulins suggest that thiol-mediated retention does not take place in or beyond the Golgi.
Molecular biology of the cell 1994;5(12):1311-24.
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1994: Guenzi S; Fra A M; Sparvoli A; Bet P; Rocco M; Sitia R
The efficiency of cysteine-mediated intracellular retention determines the differential fate of secretory IgA and IgM in B and plasma cells.
European journal of immunology 1994;24(10):2477-82.
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1993: Fra A M; Fagioli C; Finazzi D; Sitia R; Alberini C M
Quality control of ER synthesized proteins: an exposed thiol group as a three-way switch mediating assembly, retention and degradation.
The EMBO journal 1993;12(12):4755-61.
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1993: Rubartelli A; Bajetto A; Allavena G; Cozzolino F; Sitia R
Post-translational regulation of interleukin 1 beta secretion.
Cytokine 1993;5(2):117-24.
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1993: Fra A; Sitia R
The endoplasmic reticulum as a site of protein degradation.
Sub-cellular biochemistry 1993;21():143-68.
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1993: Rubartelli A; Bajetto A; Bonifaci N; Di Blas E; Solito E; Sitia R
A novel way to get out of the cell.
Cytotechnology 1993;11 Suppl 1():S37-40.
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1992: Rubartelli A; Bajetto A; Allavena G; Wollman E; Sitia R
Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.
The Journal of biological chemistry 1992;267(34):24161-4.
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1991: Valetti C; Grossi C E; Milstein C; Sitia R
Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum.
The Journal of cell biology 1991;115(4):983-94.
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1991: Rubartelli A; Sitia R
Interleukin 1 beta and thioredoxin are secreted through a novel pathway of secretion.
Biochemical Society transactions 1991;19(2):255-9.
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1991: Fra A M; Alberini C; Bet P; Finazzi D; Valetti C; Sitia R
Modulating secretion of antibodies.
Annales de biologie clinique 1991;49(5):283-6.
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1990: Alberini C M; Bet P; Milstein C; Sitia R
Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents.
Nature 1990;347(6292):485-7.
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1990: Rubartelli A; Cozzolino F; Talio M; Sitia R
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.
The EMBO journal 1990;9(5):1503-10.
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1990: Sitia R; Neuberger M; Alberini C; Bet P; Fra A; Valetti C; Williams G; Milstein C
Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine.
Cell 1990;60(5):781-90.
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1989: Cozzolino F; Rubartelli A; Aldinucci D; Sitia R; Torcia M; Shaw A; Di Guglielmo R
Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2369-73.
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1989: Guazzi S; Sitia R; Rubartelli A
Regulation of IgM biosynthesis in human chronic lymphocytic leukemia. Normal and neoplastic B cells respond differently to TPA.
Leukemia research 1989;13(12):1105-11.
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1988: Stavnezer J; Radcliffe G; Lin Y C; Nietupski J; Berggren L; Sitia R; Severinson E
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7704-8.
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1988: Sitia R; Alberini C; Biassoni R; Rubartelli A; DeAmbrosis S; Vismara D
The control of membrane and secreted heavy chain biosynthesis varies in different immunoglobulin isotypes produced by a monoclonal B cell lymphoma.
Molecular immunology 1988;25(2):189-97.
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1987: Alberini C; Biassoni R; DeAmbrosis S; Vismara D; Sitia R
Differentiation in the murine B cell lymphoma I.29: individual mu + clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching.
European journal of immunology 1987;17(4):555-62.
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1985: Sitia R; Rubartelli A; Kikutani H; Hammerling U; Stavnezer J
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2859-64.
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1985: Sitia R; Rubartelli A; Deambrosis S; Pozzi D; Hämmerling U
Differentiation in the murine B cell lymphoma I.29: inductive capacities of lipopolysaccharide and Mycoplasma fermentans products.
European journal of immunology 1985;15(6):570-5.
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1985: Rubartelli A; Sitia R; Grossi C E; Ferrarini M
Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.
Clinical immunology and immunopathology 1985;34(3):296-303.
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1984: Sitia R; Rubartelli A; Hämmerling U
The role of glycosylation in secretion and membrane expression of immunoglobulins M and A.
Molecular immunology 1984;21(8):709-19.
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1983: Rubartelli A; Sitia R; Zicca A; Grossi C E; Ferrarini M
Differentiation of chronic lymphocytic leukemia cells: correlation between the synthesis and secretion of immunoglobulins and the ultrastructure of the malignant cells.
Blood 1983;62(2):495-504.
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1983: Sitia R; Sciariada L; Zicca A; Leprini A; Ghio R; Ferrarini M
Expression of a receptor for sheep erythrocytes by B lymphocytes from a chronic lymphocytic leukemia patient.
Clinical immunology and immunopathology 1983;27(2):210-22.
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1982: Sitia R; Kikutani H; Rubartelli A; Bushkin Y; Stavnezer J; Hammerling U
Membrane-bound and secreted IgA contain structurally different alpha-chains.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(2):712-6.
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1981: Sitia R; Rubartelli A; Hammerling U
Expression of 2 immunoglobulin isotypes, IgM and IgA, with identical idiotype in the B cell lymphoma I.29.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(4):1388-94.
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1981: Kikutani H; Sitia R; Good R A; Stavnezer J
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):6436-40.
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