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Michail Sitkovsky

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Holger K Eltzschig; Michail V Sitkovsky; Simon C Robson
Purinergic signaling during inflammation.
Peter Georgiev; Stephen Hatfield; Akio Ohta; Michail V Sitkovsky; Bryan G Belikoff; Dmitriy Lukashev
Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model.
Holger K Eltzschig; Michail V Sitkovsky; Simon C Robson
Purinergic signaling during inflammation.

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All Publications

2013: Holger K Eltzschig; Michail V Sitkovsky; Simon C Robson
Purinergic signaling during inflammation.
The New England journal of medicine 2013;368(13):1260.
2013: Peter Georgiev; Stephen Hatfield; Akio Ohta; Michail V Sitkovsky; Bryan G Belikoff; Dmitriy Lukashev
Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model.
European journal of immunology 2013;43(3):655-66.
2012: Holger K Eltzschig; Michail V Sitkovsky; Simon C Robson
Purinergic signaling during inflammation.
The New England journal of medicine 2012;367(24):2322-33.
2012: Alexander Chouker; Edwin K Jackson; Ines Kaufmann; Brenda Klaunberg; Dmitriy Lukashev; André Martignoni; Akio Ohta; Jürgen Schnermann; Michail V Sitkovsky; Jerrold M Ward; Lefteris C Zacharia; Manfred Thiel
In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor.
Transplantation 2012;94(9):894-902.
2010: Kengo Moriyama; Michail V Sitkovsky
Adenosine A2A receptor is involved in cell surface expression of A2B receptor.
The Journal of biological chemistry 2010;285(50):39271-88.
2010: Alessio Paone; Roberta Galli; Chiara Gabellini; Dmitriy Lukashev; Donatella Starace; Agnes Gorlach; Paola De Cesaris; Elio Ziparo; Donatella Del Bufalo; Michail V Sitkovsky; Antonio Filippini; Anna Riccioli
Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.
Neoplasia (New York, N.Y.) 2010;12(7):539-49.
2010: Hidefumi Kojima; Ayano Kobayashi; Daisuke Sakurai; Yumiko Kanno; Hidenori Hase; Riichi Takahashi; Yoshikazu Totsuka; Gregg L Semenza; Michail V Sitkovsky; Tetsuji Kobata
Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):154-63.
2009: Akio Ohta; Akiko Ohta; Manasa Madasu; Radhika Kini; Meenakshi Subramanian; Nipun Goel; Michail V Sitkovsky
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5487-93.
2009: Stephen Hatfield; Bryan Belikoff; Dmitriy Lukashev; Michail V Sitkovsky; Akio Ohta
The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells.
Journal of leukocyte biology 2009;86(3):545-8.
2009: Madhuri Ramanathan; Wenting Luo; Balázs Csóka; György Haskó; Dmitry Lukashev; Michail V Sitkovsky; S Joseph Leibovich
Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.
Journal of leukocyte biology 2009;86(3):681-9.
2009: Akio Ohta; Michail V Sitkovsky
The adenosinergic immunomodulatory drugs.
Current opinion in pharmacology 2009;9(4):501-6.
2009: Michail V Sitkovsky
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response.
Trends in immunology 2009;30(3):102-8.
2009: Akio Ohta; J Kjaergaard; S Sharma; M Mohsin; N Goel; M Madasu; E Fradkov; Akiko Ohta; Michail V Sitkovsky
In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression.
British journal of pharmacology 2009;156(2):297-306.
2008: Michail V Sitkovsky; Jorgen Kjaergaard; Dmitriy Lukashev; Akio Ohta
Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):5947-52.
2008: Dmitriy Lukashev; Michail V Sitkovsky
Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes.
Human immunology 2008;69(7):421-5.
2008: Michail V Sitkovsky
Damage control by hypoxia-inhibited AK.
Blood 2008;111(12):5424-5.
2008: Michail V Sitkovsky; Dmitriy Lukashev; S Deaglio; K Dwyer; S C Robson; Akio Ohta
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells.
British journal of pharmacology 2008;153 Suppl 1():S457-64.
2008: Alexander Choukèr; Manfred Thiel; Dmitriy Lukashev; Jerrold M Ward; Ines Kaufmann; Sergey Apasov; Michail V Sitkovsky; Akio Ohta
Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.
Molecular medicine (Cambridge, Mass.) 2008;14(3-4):116-23.
2007: Akio Ohta; Dmitriy Lukashev; Edwin K Jackson; Bertil B. Fredholm; Michail V Sitkovsky
1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7431-8.
2007: Bertil B. Fredholm; Yijuang Chern; Rafael Franco; Michail V Sitkovsky
Aspects of the general biology of adenosine A2A signaling.
Progress in neurobiology 2007;83(5):263-76.
2007: Julie H Huang; L Isabel Cárdenas-Navia; Charles C Caldwell; Troy J Plumb; Caius G Radu; Paulo N Rocha; Tuere Wilder; Jonathan Bromberg; Bruce N Cronstein; Michail V Sitkovsky; Mark Dewhirst; Michael L Dustin
Requirements for T lymphocyte migration in explanted lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7747-55.
2007: Dmitriy Lukashev; Akio Ohta; Michail V Sitkovsky
Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues.
Cancer metastasis reviews 2007;26(2):273-9.
2007: Dmitriy Lukashev; Michail V Sitkovsky; Akio Ohta
From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy.
Purinergic signalling 2007;3(1-2):129-34.
2007: Manfred Thiel; Charles C Caldwell; Simone Kreth; Satoshi Kuboki; P Chen; Patrick Smith; Akio Ohta; Alex B Lentsch; Dmitriy Lukashev; Michail V Sitkovsky
Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.
PloS one 2007;2(9):e853.
2006: Dmitriy Lukashev; Boris Klebanov; Hidefumi Kojima; Alex Grinberg; Akio Ohta; Ludmilla Berenfeld; Roland H Wenger; Akio Ohta; Michail V Sitkovsky
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4962-5.
2006: Akio Ohta; Elieser Gorelik; Simon J Prasad; franca ronchese; Dmitriy Lukashev; Michael K K Wong; Xiaojun Huang; Sheila Caldwell; Kebin Liu; Patrick Smith; Jiang-Fan Chen; Edwin K Jackson; Sergey Apasov; Scott Abrams; Michail V Sitkovsky
A2A adenosine receptor protects tumors from antitumor T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13132-7.
2006: Ning Zhang; De Yang; Huifang Dong; Qian Chen; Dessislava I Dimitrova; Thomas J Rogers; Michail V Sitkovsky; Joost J Oppenheim
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Blood 2006;108(1):38-44.
2006: Sonja Hägele; Babak Behnam; Emanuela Borter; Jonathan Wolfe; Uwe Paasch; Dmitriy Lukashev; Michail V Sitkovsky; Roland H Wenger; Dörthe M Katschinski
TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.
FEBS letters 2006;580(15):3731-8.
2005: Jon A Buras; Bernhard Holzmann; Michail V Sitkovsky
Animal models of sepsis: setting the stage.
Nature reviews. Drug discovery 2005;4(10):854-65.
2005: Tatiana Raskovalova; Xiaojun Huang; Michail V Sitkovsky; Lefteris C Zacharia; Edwin K Jackson; Elieser Gorelik
Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4383-91.
2005: Michail V Sitkovsky; Dmitriy Lukashev
Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.
Nature reviews. Immunology 2005;5(9):712-21.
2005: Michail V Sitkovsky; Akio Ohta
The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?
Trends in immunology 2005;26(6):299-304.
2005: Manfred Thiel; Alexander Chouker; Akio Ohta; Edward Jackson; Charles C Caldwell; Patrick Smith; Dmitriy Lukashev; Iris Bittmann; Michail V Sitkovsky
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.
PLoS biology 2005;3(6):e174.
2004: Dmitriy Lukashev; Akio Ohta; Sergey Apasov; Jiang-Fan Chen; Michail V Sitkovsky
Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):21-4.
2004: Dmitriy Lukashev; Akio Ohta; Michail V Sitkovsky
Targeting hypoxia--A(2A) adenosine receptor-mediated mechanisms of tissue protection.
Drug discovery today 2004;9(9):403-9.
2004: György Haskó; Michail V Sitkovsky; Csaba Szabó
Immunomodulatory and neuroprotective effects of inosine.
Trends in pharmacological sciences 2004;25(3):152-7.
2004: Hidefumi Kojima; Brendan T Jones; Jianzhu Chen; Marilia I Cascalho; Michail V Sitkovsky
Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity.
Methods in enzymology 2004;381():218-29.
2004: Michail V Sitkovsky; Dmitriy Lukashev; Sergey Apasov; Hidefumi Kojima; Masahiro Koshiba; Charles C Caldwell; Akio Ohta; Manfred Thiel
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.
Annual review of immunology 2004;22():657-82.
2003: Gregorio Gomez; Michail V Sitkovsky
Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo.
Blood 2003;102(13):4472-8.
2003: Dmitriy Lukashev; Patrick T Smith; Charles C Caldwell; Akio Ohta; Sergey Apasov; Michail V Sitkovsky
Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs.
Biochemical pharmacology 2003;65(12):2081-90.
2003: Manfred Thiel; Charles C Caldwell; Michail V Sitkovsky
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases.
Microbes and infection / Institut Pasteur 2003;5(6):515-26.
2003: Gregorio Gomez; Michail V Sitkovsky
Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo.
The international journal of biochemistry & cell biology 2003;35(4):410-4.
2003: Michail V Sitkovsky
Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo.
Biochemical pharmacology 2003;65(4):493-501.
2003: Dmitriy Lukashev; Charles C Caldwell; Pearl Chen; Sergey Apasov; David Margulies; Michail V Sitkovsky
A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.
Journal of receptor and signal transduction research 2003;23(1):33-52.
2003: Hidefumi Kojima; Michail V Sitkovsky; Marilia I Cascalho
HIF-1 alpha deficiency perturbs T and B cell functions.
Current pharmaceutical design 2003;9(23):1827-32.
2002: Hidefumi Kojima; Hua Gu; Saeko Nomura; Charles C Caldwell; Tetsuji Kobata; Peter Carmeliet; Gregg L Semenza; Michail V Sitkovsky
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2170-4.
2001: Dmitriy Lukashev; Charles C Caldwell; Akio Ohta; P Chen; Michail V Sitkovsky
Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes.
The Journal of biological chemistry 2001;276(52):48754-63.
2001: Akio Ohta; Michail V Sitkovsky
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage.
Nature 2001;414(6866):916-20.
2001: Charles C Caldwell; Hidefumi Kojima; Dmitriy Lukashev; J Armstrong; M Farber; Sergey Apasov; Michail V Sitkovsky
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6140-9.
2001: Sergey Apasov; Michael R Blackburn; Rodney E Kellems; Patrick T Smith; Michail V Sitkovsky
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling.
The Journal of clinical investigation 2001;108(1):131-41.
2001: J M Armstrong; Jiang-Fan Chen; Michael A Schwarzschild; Sergey Apasov; Patrick T Smith; Charles C Caldwell; P Chen; H Figler; G Sullivan; S Fink; J Linden; Michail V Sitkovsky
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice.
The Biochemical journal 2001;354(Pt 1):123-30.
2000: Sergey Apasov; Jiang-Fan Chen; Patrick T Smith; Michael A Schwarzschild; J Stephen Fink; Michail V Sitkovsky
Study of A(2A) adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A(2A) receptor-unrelated lymphotoxicity.
British journal of pharmacology 2000;131(1):43-50.
2000: Sergey Apasov; Jiang-Fan Chen; P Smith; Michail V Sitkovsky
A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency.
Blood 2000;95(12):3859-67.
2000: H Kojima; M Toda; Michail V Sitkovsky
Comparison of Fas- versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells.
International immunology 2000;12(3):365-74.
1999: Frank A Redegeld; Charles C Caldwell; Michail V Sitkovsky
Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation?
Trends in pharmacological sciences 1999;20(11):453-9.
1999: Masahiro Koshiba; D L Rosin; N Hayashi; J Linden; Michail V Sitkovsky
Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.
Molecular pharmacology 1999;55(3):614-24.
1999: Sergey Apasov; Michail V Sitkovsky
The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase.
International immunology 1999;11(2):179-89.
1997: Masahiro Koshiba; H Kojima; S Huang; Sergey Apasov; Michail V Sitkovsky
Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.
The Journal of biological chemistry 1997;272(41):25881-9.
1997: Hidefumi Kojima; K Eshima; H Takayama; Michail V Sitkovsky
Leukocyte function-associated antigen-1-dependent lysis of Fas+ (CD95+/Apo-1+) innocent bystanders by antigen-specific CD8+ CTL.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2728-34.
1997: Frank A Redegeld; P Smith; Sergey Apasov; Michail V Sitkovsky
Phosphorylation of T-lymphocyte plasma membrane-associated proteins by ectoprotein kinases: implications for a possible role for ectophosphorylation in T-cell effector functions.
Biochimica et biophysica acta 1997;1328(2):151-65.
1997: S Huang; Sergey Apasov; Masahiro Koshiba; Michail V Sitkovsky
Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion.
Blood 1997;90(4):1600-10.
1997: Sergey Apasov; Masahiro Koshiba; T M Chused; Michail V Sitkovsky
Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5095-105.
1997: Masahiro Koshiba; Sergey Apasov; V Sverdlov; P Chen; Laurie Erb; John T Turner; G A Weisman; Michail V Sitkovsky
Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(3):831-6.
1997: hirotaka sugiyama; P Chen; M G Hunter; Michail V Sitkovsky
Perturbation of the expression of the catalytic subunit C alpha of cyclic AMP-dependent protein kinase inhibits TCR-triggered secretion of IL-2 by T helper hybridoma cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):171-9.
1996: Sergey Apasov; P T Smith; M T Jelonek; David Margulies; Michail V Sitkovsky
Phosphorylation of extracellular domains of T-lymphocyte surface proteins. Constitutive serine and threonine phosphorylation of the T cell antigen receptor ectodomains.
The Journal of biological chemistry 1996;271(41):25677-83.
1996: T M Chused; Sergey Apasov; Michail V Sitkovsky
Murine T lymphocytes modulate activity of an ATP-activated P2Z-type purinoceptor during differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1371-80.
1995: Sergey Apasov; Masahiro Koshiba; Frank A Redegeld; Michail V Sitkovsky
Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T-cell development and cytotoxic T lymphocyte effector functions.
Immunological reviews 1995;146():5-19.
1994: Pierre A Henkart; Michail V Sitkovsky
Cytotoxic lymphocytes. Two ways to kill target cells.
Current biology : CB 1994;4(10):923-5.
1994: Sergey Apasov; Michail V Sitkovsky
Development and antigen specificity of CD8+ cytotoxic T lymphocytes in beta 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2087-97.
1993: Sergey Apasov; Frank A Redegeld; Michail V Sitkovsky
Cell-mediated cytotoxicity: contact and secreted factors.
Current opinion in immunology 1993;5(3):404-10.
1993: G Trenn; J Sykora; C Teschendorf; R Taffs; G Brittinger; Michail V Sitkovsky
Detection of distinct sets of newly synthesized polypeptides in supernatants of TCR-triggered T cell clones. Implication for the search for new lymphokines.
Journal of immunological methods 1993;161(1):41-57.
1993: Sergey Apasov; Michail V Sitkovsky
Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2837-41.
1992: hirotaka sugiyama; P Chen; M Hunter; R Taffs; Michail V Sitkovsky
The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.
The Journal of biological chemistry 1992;267(35):25256-63.
1992: Frank A Redegeld; S Chatterjee; N A Berger; Michail V Sitkovsky
Poly-(ADP-ribose) polymerase partially contributes to target cell death triggered by cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(11):3509-16.
1992: R E Taffs; Michail V Sitkovsky
Modulation of the effector functions of cytolytic T-lymphocytes with synthetic peptide inhibitors of protein kinases.
Journal of pharmaceutical sciences 1992;81(1):37-44.
1991: Frank A Redegeld; A Filippini; Michail V Sitkovsky
Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3638-45.
1991: R E Taffs; Frank A Redegeld; Michail V Sitkovsky
Modulation of cytolytic T lymphocyte functions by an inhibitor of serine/threonine phosphatase, okadaic acid. Enhancement of cytolytic T lymphocyte-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):722-8.
1990: A Filippini; R E Taffs; Michail V Sitkovsky
Extracellular ATP in T-lymphocyte activation: possible role in effector functions.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8267-71.
1990: A Filippini; R E Taffs; T Agui; Michail V Sitkovsky
Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP.
The Journal of biological chemistry 1990;265(1):334-40.
1989: Anne H Fortier; C A Nacy; Michail V Sitkovsky
Similar molecular requirements for antigen receptor-triggered secretion of interferon and granule enzymes by cytolytic T lymphocytes.
Cellular immunology 1989;124(1):64-76.
1989: G Trenn; R Taffs; R Hohman; R Kincaid; Ethan M Shevach; Michail V Sitkovsky
Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3796-802.
1988: Michail V Sitkovsky
Mechanistic, functional and immunopharmacological implications of biochemical studies of antigen receptor-triggered cytolytic T-lymphocyte activation.
Immunological reviews 1988;103():127-60.
1988: G Trenn; H Takayama; Jane Hu-Li; William Paul; Michail V Sitkovsky
B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1101-6.
1988: H Takayama; G Trenn; Michail V Sitkovsky
Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.
The Journal of biological chemistry 1988;263(5):2330-6.
1988: G Trenn; H Takayama; W F Davidson; Herbert C Morse; Michail V Sitkovsky
Organization of lymphocyte plasma membrane. Surface protein-membrane matrix interactions in B-cell lines of different stages of differentiation.
Cell differentiation 1988;22(3):233-44.
1988: G Trenn; George R Pettit; H Takayama; Jane Hu-Li; Michail V Sitkovsky
Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):433-9.
1988: Michail V Sitkovsky; G Trenn; H Takayama
Cyclic AMP-dependent protein kinase as a part of the possible down-regulating pathway in the antigen receptor-regulated cytotoxic T lymphocyte conjugate formation and granule exocytosis.
Annals of the New York Academy of Sciences 1988;532():350-8.
1987: H Takayama; G Trenn; Michail V Sitkovsky
A novel cytotoxic T lymphocyte activation assay. Optimized conditions for antigen receptor triggered granule enzyme secretion.
Journal of immunological methods 1987;104(1-2):183-90.
1987: G Trenn; H Takayama; Michail V Sitkovsky
Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes.
Nature 1987;330(6143):72-4.
1987: Pierre A Henkart; G A Berrebi; H Takayama; W E Munger; Michail V Sitkovsky
Biochemical and functional properties of serine esterases in acidic cytoplasmic granules of cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(7):2398-405.
1987: H Takayama; G Trenn; A Kruisbeek; O Kanagawa; Michail V Sitkovsky
T cell antigen receptor triggered exocytosis in cytotoxic T lymphocytes is inhibited by soluble, but not immobilized monoclonal antibodies to Lyt-2 antigen.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(4):1014-21.
1987: H Takayama; G Trenn; W Humphrey; J A Bluestone; P A Henkart; Michail V Sitkovsky
Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(2):566-9.