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Mei-Ling Siu-Caldera

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Chemicals & Drugs

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Osteosarcoma

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Publications

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Devara Sunita Rao; Mei-Ling Siu-Caldera; Hiroko Sekimoto; Lynn Gennaro; Paul Vouros; Hiroaki Takayama; Katsuhiro Konno; Toshie Fujishima; G Satyanarayana Reddy
Metabolism of 2-methyl analogs of 1alpha,25-dihydroxyvitamin D3 in rat osteosarcoma cells (UMR 106).
Milan R Uskokovic; Anthony W Norman; Percy Manchand; G P Studzinski; Moray J Campbell; H P Koeffler; A Takeuchi; Mei-Ling Siu-Caldera; D S Rao; G Satyanarayana Reddy
Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways.
Kimie Nakagawa; Y Sowa; M Kurobe; Keiichi Ozono; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Milan R Uskokovic; Toshio Okano
Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis.

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All Publications

2002: Devara Sunita Rao; Mei-Ling Siu-Caldera; Hiroko Sekimoto; Lynn Gennaro; Paul Vouros; Hiroaki Takayama; Katsuhiro Konno; Toshie Fujishima; G Satyanarayana Reddy
Metabolism of 2-methyl analogs of 1alpha,25-dihydroxyvitamin D3 in rat osteosarcoma cells (UMR 106).
Biological & pharmaceutical bulletin 2002;25(7):845-52.
2001: Milan R Uskokovic; Anthony W Norman; Percy Manchand; G P Studzinski; Moray J Campbell; H P Koeffler; A Takeuchi; Mei-Ling Siu-Caldera; D S Rao; G Satyanarayana Reddy
Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways.
Steroids 2001;66(3-5):463-71.
2001: Kimie Nakagawa; Y Sowa; M Kurobe; Keiichi Ozono; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Milan R Uskokovic; Toshio Okano
Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis.
Steroids 2001;66(3-5):327-37.
2001: Mei-Ling Siu-Caldera; DS Rao; Norbert Astecker; AS Weiskopf; Paul Vouros; K Konno; T Fujishima; H Takayama; Sara Peleg; G Satyanarayana Reddy
Tissue specific metabolism of 1alpha,25-dihydroxy-20-epi-vitamin D3 into new metabolites with significant biological activity: studies in rat osteosarcoma cells (UMR 106 and ROS 17/2.8).
Journal of cellular biochemistry 2001;82(4):599-609.
2000: G Satyanarayana Reddy; DS Rao; Mei-Ling Siu-Caldera; Norbert Astecker; AS Weiskopf; Paul Vouros; G J Sasso; Percy Manchand; Milan R Uskokovic
1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3 and 1alpha,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3: analogs of 1alpha,25-dihydroxyvitamin D3 that resist metabolism through the C-24 oxidation pathway are metabolized through the C-3 epimerization pathway.
Archives of biochemistry and biophysics 2000;383(2):197-205.
2000: Gary H Posner; Kenneth R Crawford; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Stephen Sarabia; David Feldman; E van Etten; C Mathieu; Lynn A Gennaro; Paul Vouros; Sara Peleg; Patrick Dolan; Thomas W Kensler
Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation.
Journal of medicinal chemistry 2000;43(19):3581-6.
1999: Mei-Ling Siu-Caldera; Hiroko Sekimoto; Sara Peleg; C Nguyen; Anne-Marie Kissmeyer; Lise Binderup; AS Weiskopf; Paul Vouros; M R Uskoković; G Satyanarayana Reddy
Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
The Journal of steroid biochemistry and molecular biology 1999;71(3-4):111-21.
1999: E A Weinstein; DS Rao; Mei-Ling Siu-Caldera; Kou-Yi Tserng; Milan R Uskokovic; S Ishizuka; G Satyanarayana Reddy
Isolation and identification of 1alpha-hydroxy-24-oxovitamin D3 and 1alpha,23-dihydroxy-24-oxovitamin D3: metabolites of 1alpha,24(R)-dihydroxyvitamin D3 produced in rat kidney.
Biochemical pharmacology 1999;58(12):1965-73.
1999: DS Rao; R Dayal; Mei-Ling Siu-Caldera; RL Horst; Milan R Uskokovic; Kou-Yi Tserng; G Satyanarayana Reddy
Isolation and identification of 4,25-dihydroxyvitamin D2: a novel A-ring hydroxylated metabolite of vitamin D2.
The Journal of steroid biochemistry and molecular biology 1999;71(1-2):63-70.
1999: DS Rao; Mei-Ling Siu-Caldera; Milan R Uskokovic; RL Horst; G Satyanarayana Reddy
Physiological significance of C-28 hydroxylation in the metabolism of 1alpha,25-dihydroxyvitamin D(2).
Archives of biochemistry and biophysics 1999;368(2):319-28.
1999: Mei-Ling Siu-Caldera; Hiroko Sekimoto; AS Weiskopf; Paul Vouros; KR Muralidharan; William H Okamura; J Bishop; Anthony W Norman; M R Uskoković; inge schuster; G Satyanarayana Reddy
Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.
Bone 1999;24(5):457-63.
1999: Hiroko Sekimoto; Mei-Ling Siu-Caldera; AS Weiskopf; Paul Vouros; KR Muralidharan; William H Okamura; Milan R Uskokovic; G Satyanarayana Reddy
1alpha,25-dihydroxy-3-epi-vitamin D3: in vivo metabolite of 1alpha,25-dihydroxyvitamin D3 in rats.
FEBS letters 1999;448(2-3):278-82.
1999: W Yang; Peter A Friedman; R Kumar; John L Omdahl; Brian K May; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Sylvia Christakos
Expression of 25(OH)D3 24-hydroxylase in distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH.
The American journal of physiology 1999;276(4 Pt 1):E793-805.
1999: Moray J Campbell; Mark T Drayson; Jennifer Durham; L Wallington; Mei-Ling Siu-Caldera; G Satyanarayana Reddy; Geoffrey Brown
Metabolism of 1alpha,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation.
Molecular and cellular endocrinology 1999;149(1-2):169-83.
1998: Martin G Bischof; Mei-Ling Siu-Caldera; AS Weiskopf; P Vouros; Heide S Cross; Meinrad Peterlik; G Satyanarayana Reddy
Differentiation-related pathways of 1 alpha,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells: production of 1 alpha,25-dihydroxy-3epi-cholecalciferol.
Experimental cell research 1998;241(1):194-201.
1996: Mei-Ling Siu-Caldera; jeffrey clark; A Santos-Moore; S Peleg; Y Y Liu; M R Uskoković; Surendra Sharma; G Satyanarayana Reddy
1alpha,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1alpha,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells.
The Journal of steroid biochemistry and molecular biology 1996;59(5-6):405-12.
1996: L G Rao; M. Sutherland; G Satyanarayana Reddy; Mei-Ling Siu-Caldera; M R Uskokovic; T M Murray
Effects of 1alpha,25-dihydroxy-16ene, 23yne-vitamin D3 on osteoblastic function in human osteosarcoma SaOS-2 cells: differentiation-stage dependence and modulation by 17-beta estradiol.
Bone 1996;19(6):621-7.
1995: Mei-Ling Siu-Caldera; L Zou; M G Ehrlich; E R Schwartz; S Ishizuka; G Satyanarayana Reddy
Human osteoblasts in culture metabolize both 1 alpha, 25-dihydroxyvitamin D3 and its precursor 25-hydroxyvitamin D3 into their respective lactones.
Endocrinology 1995;136(10):4195-203.
1995: B Yeung; Paul Vouros; Mei-Ling Siu-Caldera; G Satyanarayana Reddy
Characterization of the metabolic pathway of 1,25-dihydroxy-16-ene vitamin D3 in rat kidney by on-line high performance liquid chromatography-electrospray tandem mass spectrometry.
Biochemical pharmacology 1995;49(8):1099-710.