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Gary Siuzdak
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Research Profile (preview)
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18
Trauger, Sunia
10
Shen, Zhouxin
9
Want, Elizabeth
9
Wikoff, William
9
Bothner, Brian
9
Go, Eden
8
Apon, Junefredo
7
Finn, MG
7
O'Maille, Grace
6
Nordström, Anders
5
Woo, Hin-Koon
5
Uritboonthai, Wilasinee
5
Thomas, John
5
Smith, Thomas
5
Cravatt, Benjamin
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All Publications
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2010: Dorrell Michael I; Aguilar Edith; Jacobson Ruth; Trauger Sunia A; Friedlander Jeffrey; Siuzdak Gary; Friedlander Martin
Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy.
Glia 2010;58(1):43-54.
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2009: Crews Bridgit; Wikoff William R; Patti Gary J; Woo Hin-Koon; Kalisiak Ewa; Heideker Johanna; Siuzdak Gary
Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data.
Analytical chemistry 2009;81(20):8538-44.
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2009: Wikoff William R; Kalisak Ewa; Trauger Sunia; Manchester Marianne; Siuzdak Gary
Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response.
Journal of proteome research 2009;8(7):3578-87.
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2009: Woo Hin-Koon; Go Eden P; Hoang Linh; Trauger Sunia A; Bowen Benjamin; Siuzdak Gary; Northen Trent R
Phosphonium labeling for increasing metabolomic coverage of neutral lipids using electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(12):1849-55.
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2009: Koudelka Kristopher J; Destito Giuseppe; Plummer Emily M; Trauger Sunia A; Siuzdak Gary; Manchester Marianne
Endothelial targeting of cowpea mosaic virus (CPMV) via surface vimentin.
PLoS pathogens 2009;5(5):e1000417.
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2009: Zhou Hongyan; Wu Shili; Joo Jin Young; Zhu Saiyong; Han Dong Wook; Lin Tongxiang; Trauger Sunia; Bien Geoffery; Yao Susan; Zhu Yong; Siuzdak Gary; Schöler Hans R; Duan Lingxun; Ding Sheng
Generation of induced pluripotent stem cells using recombinant proteins.
Cell stem cell 2009;4(5):381-4.
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2009: Pendyala Gurudutt; Trauger Sunia A; Kalisiak Ewa; Ellis Ronald J; Siuzdak Gary; Fox Howard S
Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys.
Journal of proteome research 2009;8(5):2253-60.
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2009: Yanes Oscar; Woo Hin-Koon; Northen Trent R; Oppenheimer Stacey R; Shriver Leah; Apon Jon; Estrada Mayra N; Potchoiba Michael J; Steenwyk Rick; Manchester Marianne; Siuzdak Gary
Nanostructure initiator mass spectrometry: tissue imaging and direct biofluid analysis.
Analytical chemistry 2009;81(8):2969-75.
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2009: Menon Angeli Lal; Poole Farris L; Cvetkovic Aleksandar; Trauger Sunia A; Kalisiak Ewa; Scott Joseph W; Shanmukh Saratchandra; Praissman Jeremy; Jenney Francis E; Wikoff William R; Apon John V; Siuzdak Gary; Adams Michael W W
Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome.
Molecular & cellular proteomics : MCP 2009;8(4):735-51.
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2009: Wikoff William R; Anfora Andrew T; Liu Jun; Schultz Peter G; Lesley Scott A; Peters Eric C; Siuzdak Gary
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3698-703.
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2009: Kalisiak Jaroslaw; Trauger Sunia A; Kalisiak Ewa; Morita Hirotoshi; Fokin Valery V; Adams Mike W W; Sharpless K Barry; Siuzdak Gary
Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach.
Journal of the American Chemical Society 2009;131(1):378-86.
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2008: Bunner Anne E; Trauger Sunia A; Siuzdak Gary; Williamson James R
Quantitative ESI-TOF analysis of macromolecular assembly kinetics.
Analytical chemistry 2008;80(24):9379-86.
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2008: Vallon Volker; Eraly Satish A; Wikoff William R; Rieg Timo; Kaler Gregory; Truong David M; Ahn Sun-Young; Mahapatra Nitish R; Mahata Sushil K; Gangoiti Jon A; Wu Wei; Barshop Bruce A; Siuzdak Gary; Nigam Sanjay K
Organic anion transporter 3 contributes to the regulation of blood pressure.
Journal of the American Society of Nephrology : JASN 2008;19(9):1732-40.
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2008: Benton H P; Wong D M; Trauger S A; Siuzdak G
XCMS2: processing tandem mass spectrometry data for metabolite identification and structural characterization.
Analytical chemistry 2008;80(16):6382-9.
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2008: Wikoff William R; Pendyala Gurudutt; Siuzdak Gary; Fox Howard S
Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques.
The Journal of clinical investigation 2008;118(7):2661-9.
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2008: Eraly Satish A; Vallon Volker; Rieg Timo; Gangoiti Jon A; Wikoff William R; Siuzdak Gary; Barshop Bruce A; Nigam Sanjay K
Multiple organic anion transporters contribute to net renal excretion of uric acid.
Physiological genomics 2008;33(2):180-92.
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2008: Northen Trent R; Lee Jinq-Chyi; Hoang Linh; Raymond Jason; Hwang Der-Ren; Yannone Steven M; Wong Chi-Huey; Siuzdak Gary
A nanostructure-initiator mass spectrometry-based enzyme activity assay.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3678-83.
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2008: Trauger Sunia A; Kalisak Ewa; Kalisiak Jaroslaw; Morita Hirotoshi; Weinberg Michael V; Menon Angeli Lal; Poole Farris L; Adams Michael W W; Siuzdak Gary
Correlating the transcriptome, proteome, and metabolome in the environmental adaptation of a hyperthermophile.
Journal of proteome research 2008;7(3):1027-35.
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2008: Nordström Anders; Want Elizabeth; Northen Trent; Lehtiö Janne; Siuzdak Gary
Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics.
Analytical chemistry 2008;80(2):421-9.
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2008: Woo Hin-Koon; Northen Trent R; Yanes Oscar; Siuzdak Gary
Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis.
Nature protocols 2008;3(8):1341-9.
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2007: Wikoff William R; Gangoiti Jon A; Barshop Bruce A; Siuzdak Gary
Metabolomics identifies perturbations in human disorders of propionate metabolism.
Clinical chemistry 2007;53(12):2169-76.
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2007: Northen Trent R; Woo Hin-Koon; Northen Michael T; Nordström Anders; Uritboonthail Winnie; Turner Kimberly L; Siuzdak Gary
High surface area of porous silicon drives desorption of intact molecules.
Journal of the American Society for Mass Spectrometry 2007;18(11):1945-9.
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2007: Northen Trent R; Yanes Oscar; Northen Michael T; Marrinucci Dena; Uritboonthai Winnie; Apon Junefredo; Golledge Stephen L; Nordström Anders; Siuzdak Gary
Clathrate nanostructures for mass spectrometry.
Nature 2007;449(7165):1033-6.
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2007: Lissauer Matthew E; Johnson Steven B; Siuzdak Gary; Bochicchio Grant; Whiteford Craig; Nussbaumer Bill; Moore Richard; Scalea Thomas M
Coagulation and complement protein differences between septic and uninfected systemic inflammatory response syndrome patients.
The Journal of trauma 2007;62(5):1082-92; discussion 1092-4.
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2007: Go Eden P; Uritboonthai Wilasinee; Apon Junefredo V; Trauger Sunia A; Nordstrom Anders; O'Maille Grace; Brittain Scott M; Peters Eric C; Siuzdak Gary
Selective metabolite and peptide capture/mass detection using fluorous affinity tags.
Journal of proteome research 2007;6(4):1492-9.
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2007: Pendyala Gurudutt; Want Elizabeth J; Webb William; Siuzdak Gary; Fox Howard S
Biomarkers for neuroAIDS: the widening scope of metabolomics.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2007;2(1):72-80.
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2007: Want Elizabeth J; Nordström Anders; Morita Hirotoshi; Siuzdak Gary
From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics.
Journal of proteome research 2007;6(2):459-68.
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2007: Mutch David M; O'Maille Grace; Wikoff William R; Wiedmer Therese; Sims Peter J; Siuzdak Gary
Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.
Genome biology 2007;8(3):R38.
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2006: Shen Zhouxin; Want Elizabeth J; Chen Wei; Keating William; Nussbaumer William; Moore Richard; Gentle Thomas M; Siuzdak Gary
Sepsis plasma protein profiling with immunodepletion, three-dimensional liquid chromatography tandem mass spectrometry, and spectrum counting.
Journal of proteome research 2006;5(11):3154-60.
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2006: Go Eden P; Wikoff William R; Shen Zhouxin; O'Maille Grace; Morita Hirotoshi; Conrads Thomas P; Nordstrom Anders; Trauger Sunia A; Uritboonthai Wilasinee; Lucas David A; Chan King C; Veenstra Timothy D; Lewicki Hanna; Oldstone Michael B; Schneemann Anette; Siuzdak Gary
Mass spectrometry reveals specific and global molecular transformations during viral infection.
Journal of proteome research 2006;5(9):2405-16.
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2006: Nordström Anders; O'Maille Grace; Qin Chuan; Siuzdak Gary
Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum.
Analytical chemistry 2006;78(10):3289-95.
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2006: Lee Jinq-Chyi; Wu Chung-Yi; Apon Junefredo V; Siuzdak Gary; Wong Chi-Huey
Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array.
Angewandte Chemie (International ed. in English) 2006;45(17):2753-7.
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2006: Smith Colin A; Want Elizabeth J; O'Maille Grace; Abagyan Ruben; Siuzdak Gary
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
Analytical chemistry 2006;78(3):779-87.
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2006: Want Elizabeth J; O'Maille Grace; Smith Colin A; Brandon Theodore R; Uritboonthai Wilasinee; Qin Chuan; Trauger Sunia A; Siuzdak Gary
Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry.
Analytical chemistry 2006;78(3):743-52.
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2006: Nordström Anders; Apon Junefredo V; Uritboonthai Wilasinee; Go Eden P; Siuzdak Gary
Surfactant-enhanced desorption/ionization on silicon mass spectrometry.
Analytical chemistry 2006;78(1):272-8.
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2006: Steenwyk Rick C; Hutzler J Matthew; Sams Jim; Shen Zhouxin; Siuzdak Gary
Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes.
Rapid communications in mass spectrometry : RCM 2006;20(24):3717-22.
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2005: Smith Colin A; O'Maille Grace; Want Elizabeth J; Qin Chuan; Trauger Sunia A; Brandon Theodore R; Custodio Darlene E; Abagyan Ruben; Siuzdak Gary
METLIN: a metabolite mass spectral database.
Therapeutic drug monitoring 2005;27(6):747-51.
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2005: Luo Guanghong; Chen Yong; Siuzdak Gary; Vertes Akos
Surface modification and laser pulse length effects on internal energy transfer in DIOS.
The journal of physical chemistry. B 2005;109(51):24450-6.
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2005: Talkington Megan W T; Siuzdak Gary; Williamson James R
An assembly landscape for the 30S ribosomal subunit.
Nature 2005;438(7068):628-32.
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2005: Want Elizabeth J; Cravatt Benjamin F; Siuzdak Gary
The expanding role of mass spectrometry in metabolite profiling and characterization.
Chembiochem : a European journal of chemical biology 2005;6(11):1941-51.
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2005: Lacy Eilyn R; Wang Yuefeng; Post Jeremy; Nourse Amanda; Webb William; Mapelli Marina; Musacchio Andrea; Siuzdak Gary; Kriwacki Richard W
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
Journal of molecular biology 2005;349(4):764-73.
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2005: Go E P; Apon J V; Luo G; Saghatelian A; Daniels R H; Sahi V; Dubrow R; Cravatt B F; Vertes A; Siuzdak G
Desorption/ionization on silicon nanowires.
Analytical chemistry 2005;77(6):1641-6.
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2005: Bothner Brian; Taylor Derek; Jun Bokkyoo; Lee Kelly K; Siuzdak Gary; Schultz Christian P; Johnson John E
Maturation of a tetravirus capsid alters the dynamic properties and creates a metastable complex.
Virology 2005;334(1):17-27.
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2004: Saghatelian Alan; Trauger Sunia A; Want Elizabeth J; Hawkins Edward G; Siuzdak Gary; Cravatt Benjamin F
Assignment of endogenous substrates to enzymes by global metabolite profiling.
Biochemistry 2004;43(45):14332-9.
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2004: Shen Zhouxin; Thomas John J; Siuzdak Gary; Blackledge Robert D
A case study on forensic polymer analysis by DIOS-MS: the suspect who gave us the SLIP.
Journal of forensic sciences 2004;49(5):1028-35.
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2004: Meng Jun-Cai; Siuzdak Gary; Finn M G
Affinity mass spectrometry from a tailored porous silicon surface.
Chemical communications (Cambridge, England) 2004;(18):2108-9.
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2004: Trauger Sunia A; Wu Eugene; Bark Steve J; Nemerow Glen R; Siuzdak Gary
The identification of an adenovirus receptor by using affinity capture and mass spectrometry.
Chembiochem : a European journal of chemical biology 2004;5(8):1095-9.
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2004: Trauger Sunia A; Go Eden P; Shen Zhouxin; Apon Junefredo V; Compton Bruce J; Bouvier Edouard S P; Finn M G; Siuzdak Gary
High sensitivity and analyte capture with desorption/ionization mass spectrometry on silylated porous silicon.
Analytical chemistry 2004;76(15):4484-9.
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2004: Shen Zhouxin; Go Eden P; Gamez Alejandra; Apon Junefredo V; Fokin Valery; Greig Mike; Ventura Manuel; Crowell John E; Blixt Ola; Paulson James C; Stevens Raymond C; Finn M G; Siuzdak Gary
A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform.
Chembiochem : a European journal of chemical biology 2004;5(7):921-7.
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2004: Wu Eugene; Trauger Sunia A; Pache Lars; Mullen Tina-Marie; von Seggern Daniel J; Siuzdak Gary; Nemerow Glen R
Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.
Journal of virology 2004;78(8):3897-905.
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2004: Bothner Brian; Siuzdak Gary
Electrospray ionization of a whole virus: analyzing mass, structure, and viability.
Chembiochem : a European journal of chemical biology 2004;5(3):258-60.
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2004: Meng Jun-Cai; Averbuj Claudia; Lewis Warren G; Siuzdak Gary; Finn M G
Cleavable linkers for porous silicon-based mass spectrometry.
Angewandte Chemie (International ed. in English) 2004;43(10):1255-60.
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2003: Go Eden P; Shen Zhouxin; Harris Ken; Siuzdak Gary
Quantitative analysis with desorption/ionization on silicon mass spectrometry using electrospray deposition.
Analytical chemistry 2003;75(20):5475-9.
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2003: Reisdorph Nichole; Thomas John J; Katpally Umesh; Chase Elaine; Harris Ken; Siuzdak Gary; Smith Thomas J
Human rhinovirus capsid dynamics is controlled by canyon flexibility.
Virology 2003;314(1):34-44.
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2003: Go Eden P; Prenni Jessica E; Wei Jing; Jones Arianna; Hall Steven C; Witkowska H Ewa; Shen Zhouxin; Siuzdak Gary
Desorption/ionization on silicon time-of-flight/time-of-flight mass spectrometry.
Analytical chemistry 2003;75(10):2504-6.
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2003: Yao Sulan; Meng Jun-Cai; Siuzdak Gary; Finn M G
New catalysts for the asymmetric hydrosilylation of ketones discovered by mass spectrometry screening.
The Journal of organic chemistry 2003;68(7):2540-6.
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2002: Smith Thomas J; Schmidt Timothy; Fang Jie; Wu Jane; Siuzdak Gary; Stanley Charles A
The structure of apo human glutamate dehydrogenase details subunit communication and allostery.
Journal of molecular biology 2002;318(3):765-77.
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2001: Thomas J J; Shen Z; Crowell J E; Finn M G; Siuzdak G
Desorption/ionization on silicon (DIOS): a diverse mass spectrometry platform for protein characterization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4932-7.
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2001: Bark S J; Muster N; Yates J R; Siuzdak G
High-temperature protein mass mapping using a thermophilic protease.
Journal of the American Chemical Society 2001;123(8):1774-5.
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2001: Broo K; Wei J; Marshall D; Brown F; Smith T J; Johnson J E; Schneemann A; Siuzdak G
Viral capsid mobility: a dynamic conduit for inactivation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2274-7.
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2001: Shen Z; Thomas J J; Averbuj C; Broo K M; Engelhard M; Crowell J E; Finn M G; Siuzdak G
Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry.
Analytical chemistry 2001;73(3):612-9.
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2000: Bothner B; Chavez R; Wei J; Strupp C; Phung Q; Schneemann A; Siuzdak G
Monitoring enzyme catalysis with mass spectrometry.
The Journal of biological chemistry 2000;275(18):13455-9.
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2000: Thomas J J; Bakhtiar R; Siuzdak G
Mass spectrometry in viral proteomics.
Accounts of chemical research 2000;33(3):179-87.
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2000: Kriwacki R W; Siuzdak G
Probing protein-protein interactions with mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2000;146():223-38.
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1999: Hollenbeck T P; Siuzdak G; Blackledge R D
Electrospray and MALDI mass spectrometry in the identification of spermicides in criminal investigations.
Journal of forensic sciences 1999;44(4):783-8.
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1999: Chatman K; Hollenbeck T; Hagey L; Vallee M; Purdy R; Weiss F; Siuzdak G
Nanoelectrospray mass spectrometry and precursor ion monitoring for quantitative steroid analysis and attomole sensitivity.
Analytical chemistry 1999;71(13):2358-63.
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1999: Wei J; Buriak J M; Siuzdak G
Desorption-ionization mass spectrometry on porous silicon.
Nature 1999;399(6733):243-6.
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1999: Takayama S; Chung S J; Igarashi Y; Ichikawa Y; Sepp A; Lechler R I; Wu J; Hayashi T; Siuzdak G; Wong C H
Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approach.
Bioorganic & medicinal chemistry 1999;7(2):401-9.
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1999: Bothner B; Schneemann A; Marshall D; Reddy V; Johnson J E; Siuzdak G
Crystallographically identical virus capsids display different properties in solution.
Nature structural biology 1999;6(2):114-6.
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1999: Tsui V; Garcia C; Cavagnero S; Siuzdak G; Dyson H J; Wright P E
Quench-flow experiments combined with mass spectrometry show apomyoglobin folds through and obligatory intermediate.
Protein science : a publication of the Protein Society 1999;8(1):45-9.
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1999: Marmey P; Bothner B; Jacquot E; de Kochko A; Ong C A; Yot P; Siuzdak G; Beachy R N; Fauquet C M
Rice tungro bacilliform virus open reading frame 3 encodes a single 37-kDa coat protein.
Virology 1999;253(2):319-26.
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1998: Owens D R; Bothner B; Phung Q; Harris K; Siuzdak G
Aspects of oligonucleotide and peptide sequencing with MALDI and electrospray mass spectrometry.
Bioorganic & medicinal chemistry 1998;6(9):1547-54.
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1998: Lewis J K; Bendahmane M; Smith T J; Beachy R N; Siuzdak G
Identification of viral mutants by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8596-601.
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1998: Lewis J K; Bothner B; Smith T J; Siuzdak G
Antiviral agent blocks breathing of the common cold virus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6774-8.
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1998: Siuzdak G
Probing viruses with mass spectrometry.
Journal of mass spectrometry : JMS 1998;33(3):203-11.
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1998: Bothner B; Dong X F; Bibbs L; Johnson J E; Siuzdak G
Evidence of viral capsid dynamics using limited proteolysis and mass spectrometry.
The Journal of biological chemistry 1998;273(2):673-6.
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1998: Siuzdak G; Lewis J K
Applications of mass spectrometry in combinatorial chemistry.
Biotechnology and bioengineering 1998;61(2):127-34.
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1997: Wu J; Takayama S; Wong C H; Siuzdak G
Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors.
Chemistry & biology 1997;4(9):653-7.
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1997: Wu J; Chatman K; Harris K; Siuzdak G
An automated MALDI mass spectrometry approach for optimizing cyclosporin extraction and quantitation.
Analytical chemistry 1997;69(18):3767-71.
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1997: Kriwacki R W; Wu J; Tennant L; Wright P E; Siuzdak G
Probing protein structure using biochemical and biophysical methods. Proteolysis, matrix-assisted laser desorption/ionization mass spectrometry, high-performance liquid chromatography and size-exclusion chromatography of p21Waf1/Cip1/Sdi1.
Journal of chromatography. A 1997;777(1):23-30.
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1996: Fitzgerald M C; Siuzdak G
Biochemical mass spectrometry: worth the weight?
Chemistry & biology 1996;3(9):707-15.
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1996: Siuzdak G; Bothner B; Yeager M; Brugidou C; Fauquet C M; Hoey K; Chang C M
Mass spectrometry and viral analysis.
Chemistry & biology 1996;3(1):45-8.
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1995: Cravatt B F; Prospero-Garcia O; Siuzdak G; Gilula N B; Henriksen S J; Boger D L; Lerner R A
Chemical characterization of a family of brain lipids that induce sleep.
Science (New York, N.Y.) 1995;268(5216):1506-9.
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1995: Krebs J F; Siuzdak G; Dyson H J; Stewart J D; Benkovic S J
Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry.
Biochemistry 1995;34(3):720-3.
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1994: Lerner R A; Siuzdak G; Prospero-Garcia O; Henriksen S J; Boger D L; Cravatt B F
Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9505-8.
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1994: Stewart J D; Krebs J F; Siuzdak G; Berdis A J; Smithrud D B; Benkovic S J
Dissection of an antibody-catalyzed reaction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7404-9.
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1993: Rideout D; Bustamante A; Siuzdak G
Cationic drug analysis using matrix-assisted laser desorption/ionization mass spectrometry: application to influx kinetics, multidrug resistance, and intracellular chemical change.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10226-9.
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