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Alexios-Leandros Skaltsounis

Research Profile

Genes & Molecular Sequences

Molecular Structure

Geographic Areas

Greece

Concepts & Ideas

Procedures

Chemicals & Drugs

Phenomena

Magnetic Resonance Spectroscopy

Anatomy

Tumor Cells, Cultured

Living Beings

Disorders

Leukemia L1210

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Publications

TOP 3
Job Tchoumtchoua; Jean Claude Mbanya; Dieudonné Njamen; Alexios-Leandros Skaltsounis; Maria Halabalaki
Structure-oriented UHPLC-LTQ Orbitrap-based approach as a dereplication strategy for the identification of isoflavonoids from Amphimas pterocarpoides crude extract.
Thomas Michel; Maria Halabalaki; Alexios-Leandros Skaltsounis
New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources.
Wirginia Kukula-Koch; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Kazimierz Glowniak; Maria Halabalaki; Eleftherios Kalpoutzakis
Influence of extraction procedures on phenolic content and antioxidant activity of Cretan barberry herb.

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All Publications

2013: Job Tchoumtchoua; Jean Claude Mbanya; Dieudonné Njamen; Alexios-Leandros Skaltsounis; Maria Halabalaki
Structure-oriented UHPLC-LTQ Orbitrap-based approach as a dereplication strategy for the identification of isoflavonoids from Amphimas pterocarpoides crude extract.
Journal of mass spectrometry : JMS 2013;48(5):561-75.
2013: Thomas Michel; Maria Halabalaki; Alexios-Leandros Skaltsounis
New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources.
Planta medica 2013;79(7):514-32.
2013: Wirginia Kukula-Koch; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Kazimierz Glowniak; Maria Halabalaki; Eleftherios Kalpoutzakis
Influence of extraction procedures on phenolic content and antioxidant activity of Cretan barberry herb.
Food chemistry 2013;138(1):406-13.
2013: Johanne Polasek; Bambang Prajogo; Emerson Ferreira Queiroz; Alexios-Leandros Skaltsounis; Jean-Luc Wolfender; Michael N Alexis; Maria Halabalaki; Laurence Marcourt; Aggeliki K Meligova; Kurt Hostettmann
Peltogynoids and 2-phenoxychromones from Peltophorum pterocarpum and evaluation of their estrogenic activity.
Planta medica 2013;79(6):480-6.
2013: Joannis D Kyriazis; Panagiotis Polychronopoulos; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Eleni Dotsika
Leishmanicidal activity assessment of olive tree extracts.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2013;20(3-4):275-81.
2012: Konstantina Vougogiannopoulou; Alexios-Leandros Skaltsounis
From Tyrian purple to kinase modulators: naturally halogenated indirubins and synthetic analogues.
Planta medica 2012;78(14):1515-28.
2012: Argyro Vontzalidou; Grigoris Zoidis; Nektarios Aligiannis; Eliza Chaita; George Lambrinidis; Maria Makropoulou; Emmanuel Mikros; Alexios-Leandros Skaltsounis
Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(17):5523-6.
2012: Michael S Christodoulou; Nikolas Fokialakis; Richard Jove; Sangkil Nam; Alexios-Leandros Skaltsounis; Serkos A Haroutounian
Synthesis and in vitro biological evaluation of novel pyrazole derivatives as potential antitumor agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2012;8(5):779-88.
2012: Eirini Kouloura; Marie-Christine Lallemand; Marc Litaudon; Sangkil Nam; Khalijah Awang; Hamid A Hadi; Maria Halabalaki; Richard Jove; Alexios-Leandros Skaltsounis
Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.
Journal of natural products 2012;75(7):1270-6.
2012: Chrysoula I Spanou; Demetrios Stagos; Aristidis S Veskoukis; Kalliopi Liadaki; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Maria Anastasiadi; Apostolos Angelis; Serkos A Haroutounian; Demetrios Kouretas
Effects of Greek legume plant extracts on xanthine oxidase, catalase and superoxide dismutase activities.
Journal of physiology and biochemistry 2012;68(1):37-45.
2012: Maria Makropoulou; Harris Pratsinis; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Zacharoula Gonou-Zagou; Nikolas Fokialakis
Antioxidant and cytotoxic activity of the wild edible mushroom Gomphus clavatus.
Journal of medicinal food 2012;15(2):216-21.
2012: Alexandros Papachristoforou; Chrisovalantis Papaefthimiou; Alexios-Leandros Skaltsounis; Aikaterini Termentzi; Gérard Arnold; Nikolas Fokialakis; Alexia Kagiava; Max Watkins; George Theophilidis
The bite of the honeybee: 2-heptanone secreted from honeybee mandibles during a bite acts as a local anaesthetic in insects and mammals.
PloS one 2012;7(10):e47432.
2012: S Paraschos; Sofia Mitakou; Alexios-Leandros Skaltsounis
Chios gum mastic: A review of its biological activities.
Current medicinal chemistry 2012;19(14):2292-302.
2012: Chrysoula Spanou; Aristidis S Veskoukis; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Apostolos Angelis; Thalia Kerasioti; Maria Kontou; Demetrios Kouretas
Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidase.
PloS one 2012;7(3):e32214.
2011: Alexios-Leandros Skaltsounis; Nicolas Gaboriaud-Kolar
(WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation.
Expert opinion on therapeutic patents 2011;21(12):1925-9.
2011: Dimitrios Ntountaniotis; Constantinos Potamitis; Michael Rappolt; Eleni Siapi; Alexios-Leandros Skaltsounis; Maria Halabalaki; Petros Chatzigeorgiou; Simona Golic Grdadolnik; Gregor Mali; Halabalaki Maria; Thomas Mavromoustakos
Thermal, dynamic and structural properties of drug AT1 antagonist olmesartan in lipid bilayers.
Biochimica et biophysica acta 2011;1808(12):2995-3006.
2011: Maria Tselepi; Evaggelia Papachristou; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Apostolos Angelis; Aikaterini Emmanouilidi; Demetrios Kouretas; Kalliopi Liadaki
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
Journal of natural products 2011;74(11):2362-70.
2011: Nikolaos Lemonakis; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Nikolaos Kostomitsopoulos; Constantin Tamvakopoulos
Oral administration of chios mastic gum or extracts in mice: quantification of triterpenic acids by liquid chromatography-tandem mass spectrometry.
Planta medica 2011;77(17):1916-23.
2011: Maria Halabalaki; Sofia Mitakou; Aristea Paschali; François Tillequin; Aurélie Urbain; Alexios-Leandros Skaltsounis
Quercetin and kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]-7-O-α-L-rhamnopyranosides from Anthyllis hermanniae: structure determination and conformational studies.
Journal of natural products 2011;74(9):1939-45.
2011: Apostolis Angelis; Maria Halabalaki; Nektarios Aligiannis; Aurélie Urbain; Alexios-Leandros Skaltsounis
One-step isolation of γ-oryzanol from rice bran oil by non-aqueous hydrostatic countercurrent chromatography.
Journal of separation science 2011;34(18):2528-37.
2011: Konstantina Vougogiannopoulou; Nektarios Aligiannis; Charles Cantrell; Nikolas Fokialakis; Alexios-Leandros Skaltsounis
Simple indole alkaloids from the neotropical rutaceous tree Raputia simulans.
Planta medica 2011;77(13):1559-61.
2011: Joseph Hayes; Vicky T Skamnaki; Georgios Archontis; Christos Lamprakis; Josephine Sarrou; Nicolas Bischler; Alexios-Leandros Skaltsounis; Spyros Zographos; Nikos G Oikonomakos
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined.
Proteins 2011;79(3):703-19.
2011: Claudia Kühn; Niki Eliza Arapogianni; Maria Halabalaki; Jana Hempel; Nicole Hunger; Jannette Wober; Alexios-Leandros Skaltsounis; Günter Vollmer
Constituents from Cistus salvifolius (Cistaceae) activate peroxisome proliferator-activated receptor-γ but not -δ and stimulate glucose uptake by adipocytes.
Planta medica 2011;77(4):346-53.
2011: Aikaterini Termentzi; Nikolas Fokialakis; Alexios-Leandros Skaltsounis
Natural resins and bioactive natural products thereof as potential antimicrobial agents.
Current pharmaceutical design 2011;17(13):1267-90.
2010: Sefirin Djiogue; Dieudonné Njamen; Maria Halabalaki; Georg Kretzschmar; Antje Beyer; Jean-Claude Mbanya; Alexios-Leandros Skaltsounis; Günter Vollmer
Estrogenic properties of naturally occurring prenylated isoflavones in U2OS human osteosarcoma cells: Structure-activity relationships.
The Journal of steroid biochemistry and molecular biology 2010;120(4-5):184-91.
2010: Konstantina Vougogiannopoulou; Nikolas Fokialakis; Nektarios Aligiannis; Charles L Cantrell; Alexios-Leandros Skaltsounis
The raputindoles: novel cyclopentyl bisindole alkaloids from Raputia simulans.
Organic letters 2010;12(9):1908-11.
2010: Aurélie Urbain; Pierre Corbeiller; Nektarios Aligiannis; Maria Halabalaki; Alexios-Leandros Skaltsounis
Hydrostatic countercurrent chromatography and ultra high pressure LC: Two fast complementary separation methods for the preparative isolation and the analysis of the fragrant massoia lactones.
Journal of separation science 2010;33(9):1198-203.
2010: Ruben F Tchokouaha; Xanthippi Alexi; Elizabeth Chosson; Thierry BESSON; Alexios-Leandros Skaltsounis; Elisabeth Seguin; Michael N Alexis; Jean Wandji
Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells.
Journal of enzyme inhibition and medicinal chemistry 2010;25(2):228-33.
2010: Prokopios Magiatis; Panagiotis Polychronopoulos; Alexios-Leandros Skaltsounis; Olivier Lozach; Laurent Meijer; Diane B Miller; James P O'Callaghan
Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis.
Neurotoxicology and teratology 2010;32(2):212-9.
2010: Augustine Ahmadu; Agunu Abdulkarim; Raphaël Grougnet; vassilios myrianthopoulos; François Tillequin; Prokopios Magiatis; Alexios-Leandros Skaltsounis
Two new peltogynoids from Acacia nilotica Delile with kinase inhibitory activity.
Planta medica 2010;76(5):458-60.
2010: Evagelia Zoidou; Eleni Melliou; Evagelos Gikas; ANTHONY TSARBOPOULOS; Prokopios Magiatis; Alexios-Leandros Skaltsounis
Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
Journal of agricultural and food chemistry 2010;58(1):46-50.
2009: Maria Anastasiadi; Athina Zira; Prokopios Magiatis; Serkos A Haroutounian; Alexios-Leandros Skaltsounis; Emmanuel Mikros
1H NMR-based metabonomics for the classification of Greek wines according to variety, region, and vintage. Comparison with HPLC data.
Journal of agricultural and food chemistry 2009;57(23):11067-74.
2009: Marina Kritsanida; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Youyi Peng; Peng Li; Lawrence Wennogle
Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.
Journal of natural products 2009;72(12):2199-202.
2009: Evangelia Xingi; Despina Smirlis; vassilios myrianthopoulos; Prokopios Magiatis; Karen M Grant; Laurent Meijer; Emmanuel Mikros; Alexios-Leandros Skaltsounis; Ketty Soteriadou
6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis.
International journal for parasitology 2009;39(12):1289-303.
2009: Sefirin Djiogue; Maria Halabalaki; Xanthippi Alexi; Dieudonne Njamen; Zacharias Tanee Fomum; Michael N Alexis; Alexios-Leandros Skaltsounis
Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor.
Journal of natural products 2009;72(9):1603-7.
2009: Ioanna Andreadou; Maria Papaefthimiou; Athina Zira; Maria A Constantinou; Fragiska Sigala; Alexios-Leandros Skaltsounis; Anna Tsantili-Kakoulidou; Efstathios K Iliodromitis; Dimitrios T Kremastinos; Emmanuel Mikros
Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein.
NMR in biomedicine 2009;22(6):585-92.
2009: Lemonia Valianou; Konstantina Stathopoulou; Ioannis Karapanagiotis; Prokopios Magiatis; Eleni Pavlidou; Alexios-Leandros Skaltsounis; Yannis Chryssoulakis
Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles.
Analytical and bioanalytical chemistry 2009;394(3):871-82.
2009: Georgios Kazantzoglou; Prokopios Magiatis; Eleftherios Kalpoutzakis; Alexios-Leandros Skaltsounis
Polygonophenone, the first MEM-substituted natural product, from Polygonum maritimum.
Journal of natural products 2009;72(2):187-9.
2009: Sofia Pasi; Nektarios Aligiannis; Harris Pratsinis; Alexios-Leandros Skaltsounis; Ioanna Chinou
Biologically active triterpenoids from Cephalaria ambrosioides.
Planta medica 2009;75(2):163-7.
2008: Emmanouil N Papadakis; Despina Lazarou; Raphaël Grougnet; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Euphemia Papadopoulou-Mourkidou; Athanasios I Papadopoulos
Effect of the form of the sesame-based diet on the absorption of lignans.
The British journal of nutrition 2008;100(6):1213-9.
2008: Maria Halabalaki; Xanthippi Alexi; Nektarios Aligiannis; Michael N Alexis; Alexios-Leandros Skaltsounis
Ebenfurans IV-VIII from Onobrychis ebenoides: evidence that C-prenylation is the key determinant of the cytotoxicity of 3-formyl-2-arylbenzofurans.
Journal of natural products 2008;71(11):1934-7.
2008: Konstantina Vougogiannopoulou; Yoan Ferandin; Karima Bettayeb; vassilios myrianthopoulos; Olivier Lozach; Yunzhen Fan; Carl Hirschie Johnson; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Emmanuel Mikros; Laurent Meijer
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Journal of medicinal chemistry 2008;51(20):6421-31.
2008: Caroline Puel; Julie Mardon; Apostolis Agalias; Marie-Jeanne Davicco; Patrice Lebecque; Andre Mazur; Marie-Noelle Horcajada; Alexios-Leandros Skaltsounis; Veronique Coxam
Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model.
Journal of agricultural and food chemistry 2008;56(20):9417-22.
2008: Chrysoula Spanou; Georgia Bourou; Albiona Dervishi; Nektarios Aligiannis; Apostolos Angelis; Dimitri Komiotis; Alexios-Leandros Skaltsounis; Demetrios Kouretas
Antioxidant and chemopreventive properties of polyphenolic compounds derived from Greek legume plant extracts.
Journal of agricultural and food chemistry 2008;56(16):6967-76.
2008: George Gaitanis; Prokopios Magiatis; Konstantina Stathopoulou; Ioannis D Bassukas; Evangelos Alexopoulos; Aristea Velegraki; Alexios-Leandros Skaltsounis
AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis.
The Journal of investigative dermatology 2008;128(7):1620-5.
2007: Alexandre Berthier; Corinne Girard; Aurélie Grandvuillemin; Frédéric Muyard; Alexios-Leandros Skaltsounis; Michèle Jouvenot; Régis Delage-Mourroux
Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity.
Planta medica 2007;73(14):1447-51.
2007: Chrysoula Spanou; Demetrios Stagos; L Tousias; A Angelis; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Demetrios Kouretas
Assessment of antioxidant activity of extracts from unique Greek varieties of Leguminosae plants using in vitro assays.
Anticancer research 2007;27(5A):3403-10.
2007: vassilios myrianthopoulos; Prokopios Magiatis; Yoan Ferandin; Alexios-Leandros Skaltsounis; Laurent Meijer; Emmanuel Mikros
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
Journal of medicinal chemistry 2007;50(17):4027-37.
2007: Efrosini S Katsanou; Maria Halabalaki; Nektarios Aligiannis; Sofia Mitakou; Alexios-Leandros Skaltsounis; Xanthippi Alexi; Harris Pratsinis; Michael N Alexis
Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):228-36.
2007: Apostolos Agalias; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Emmanuel Mikros; ANTHONY TSARBOPOULOS; Evagelos Gikas; Ioannis Spanos; Thrasyvoulos Manios
A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
Journal of agricultural and food chemistry 2007;55(7):2671-6.
2007: Sotirios Paraschos; Prokopios Magiatis; Sofia Mitakou; Kalliopi Petraki; Antonios Kalliaropoulos; Petros Maragkoudakis; Andreas Mentis; Dionyssios Nicholas Sgouras; Alexios-Leandros Skaltsounis
In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori.
Antimicrobial agents and chemotherapy 2007;51(2):551-9.
2006: Judit Ribas; Karima Bettayeb; Yoan Ferandin; Marie Knockaert; X Garrofé-Ochoa; Frank Totzke; Christoph Schächtele; J Mester; Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; J Boix; Laurent Meijer
7-Bromoindirubin-3'-oxime induces caspase-independent cell death.
Oncogene 2006;25(47):6304-18.
2006: Raphaël Grougnet; Prokopios Magiatis; Sofia Mitaku; Aris Terzis; François Tillequin; Alexios-Leandros Skaltsounis
New lignans from the perisperm of Sesamum indicum.
Journal of agricultural and food chemistry 2006;54(20):7570-4.
2006: Caroline Puel; Jacinthe Mathey; Apostolos Agalias; Séraphin Kati-Coulibaly; Julie Mardon; Christiane Obled; Marie-Jeanne Davicco; Patrice Lebecque; Marie-Noëlle Horcajada; Alexios-Leandros Skaltsounis; Véronique Coxam
Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat.
Clinical nutrition (Edinburgh, Scotland) 2006;25(5):859-68.
2006: Nikolas Fokialakis; Weste L A Osbrink; Leonid K Mamonov; Nadejda G Gemejieva; Amelia B Mims; Alexios-Leandros Skaltsounis; Alan R Lax; Charles L Cantrell
Antifeedant and toxicity effects of thiophenes from four Echinops species against the Formosan subterranean termite, Coptotermes formosanus.
Pest management science 2006;62(9):832-8.
2006: Nikolas Fokialakis; Eleftherios Kalpoutzakis; Babu L Tekwani; Alexios-Leandros Skaltsounis; Stephen O Duke
Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives thereof.
Biological & pharmaceutical bulletin 2006;29(8):1775-8.
2006: Ioanna Andreadou; Efstathios K Iliodromitis; Emmanuel Mikros; Maria A Constantinou; Apostolos Agalias; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Elli Kamber; Anna Tsantili-Kakoulidou; Dimitrios Th Kremastinos
The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits.
The Journal of nutrition 2006;136(8):2213-9.
2006: Fotini N Bazoti; Evagelos Gikas; Alexios-Leandros Skaltsounis; ANTHONY TSARBOPOULOS
Development of a liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI MS/MS) method for the quantification of bioactive substances present in olive oil mill wastewaters.
Analytica chimica acta 2006;573-574():258-66.
2006: Yoan Ferandin; Karima Bettayeb; Marina Kritsanida; Olivier Lozach; Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Laurent Meijer
3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.
Journal of medicinal chemistry 2006;49(15):4638-49.
2006: Elisabeth M Perchellet; Mary M Ward; Alexios-Leandros Skaltsounis; Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Jean-Pierre H Perchellet
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.
Anticancer research 2006;26(4B):2791-804.
2006: Maria Halabalaki; Xanthippi Alexi; Nektarios Aligiannis; George Lambrinidis; Harris Pratsinis; Ida Florentin; Sofia Mitakou; Emmanuel Mikros; Alexios-Leandros Skaltsounis; Michael N Alexis
Estrogenic activity of isoflavonoids from Onobrychis ebenoides.
Planta medica 2006;72(6):488-93.
2006: Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Harris Pratsinis; Dimitris Kletsas
Design and synthesis of novel amino-substituted xanthenones and benzo[b]xanthenones: evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D x 5 cells.
Bioorganic & medicinal chemistry 2006;14(9):2910-34.
2006: Nikolas Fokialakis; Charles L Cantrell; Stephen O Duke; Alexios-Leandros Skaltsounis; David E Wedge
Antifungal activity of thiophenes from Echinops ritro.
Journal of agricultural and food chemistry 2006;54(5):1651-5.
2005: John Lekakis; Loukianos S Rallidis; Ioanna Andreadou; Georgia Vamvakou; Georgios Kazantzoglou; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Dimitrios Th Kremastinos
Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2005;12(6):596-600.
2005: Ioannis K Kostakis; Roxane Tenta; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Harris Pratsinis; Dimitris Kletsas
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells.
Bioorganic & medicinal chemistry letters 2005;15(22):5057-60.
2005: Raphaël Grougnet; Prokopios Magiatis; Nikolas Fokialakis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet; Marc Litaudon
Koniamborine, the first pyrano[3,2-b]indole alkaloid and other secondary metabolites from Boronella koniambiensis.
Journal of natural products 2005;68(7):1083-6.
2005: Eleni Melliou; Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; Efrosini Chinou; Ioanna Chinou
Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity.
Journal of natural products 2005;68(1):78-82.
2004: Karen M Grant; Morag H Dunion; Vanessa Yardley; Alexios-Leandros Skaltsounis; Doris Marko; Gerhard Eisenbrand; Simon L Croft; Laurent Meijer; Jeremy C Mottram
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.
Antimicrobial agents and chemotherapy 2004;48(8):3033-42.
2004: Caroline Puel; A Quintin; Apostolos Agalias; Jacinthe Mathey; Christiane Obled; Andrzej Mazur; Marie-Jeanne Davicco; Patrice Lebecque; Alexios-Leandros Skaltsounis; Véronique Coxam
Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat.
The British journal of nutrition 2004;92(1):119-27.
2004: Fujinori Hanawa; Nikolas Fokialakis; Alexios-Leandros Skaltsounis
Photo-activated DNA binding and antimicrobial activities of furoquinoline and pyranoquinolone alkaloids from rutaceae.
Planta medica 2004;70(6):531-5.
2004: Konstantinos Athanasas; Prokopios Magiatis; Nikolas Fokialakis; Alexios-Leandros Skaltsounis; Harris Pratsinis; Dimitris Kletsas
Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures.
Journal of natural products 2004;67(6):973-7.
2004: Konstantia Graikou; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Ioanna Chinou; Sylvie Michel; François Tillequin; Marc Litaudon
New diterpenes from Croton insularis.
Journal of natural products 2004;67(4):685-8.
2004: Nikolas Fokialakis; George Lambrinidis; Dimitra J Mitsiou; Nektarios Aligiannis; Sofia Mitakou; Alexios-Leandros Skaltsounis; Harris Pratsinis; Emmanuel Mikros; Michael N Alexis
A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins.
Chemistry & biology 2004;11(3):397-406.
2004: Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; vassilios myrianthopoulos; Emmanuel Mikros; Aldo Tarricone; Andrea Musacchio; S Mark Roe; Laurence H Pearl; Maryse Leost; Paul Greengard; Laurent Meijer
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Journal of medicinal chemistry 2004;47(4):935-46.
2004: Georgios Kazantzoglou; Prokopios Magiatis; Georgios I Panoutsopoulos; Alexios-Leandros Skaltsounis
Dorycnioside, a new phenylbutanone glucoside from Dorycnium pentaphyllum subsp. herbaceum.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(1-2):23-6.
2003: Laurent Meijer; Alexios-Leandros Skaltsounis; Prokopios Magiatis; Panagiotis Polychronopoulos; Marie Knockaert; Maryse Leost; Xiaozhou P Ryan; Claudia Alin Vonica; Ali H Brivanlou; Rana Dajani; Claudia Crovace; Cataldo Tarricone; Andrea Musacchio; S Mark Roe; Laurence H Pearl; Paul Greengard
GSK-3-selective inhibitors derived from Tyrian purple indirubins.
Chemistry & biology 2003;10(12):1255-66.
2003: Eleni Melliou; Prokopios Magiatis; Alexios-Leandros Skaltsounis
Alkylresorcinol derivatives and sesquiterpene lactones from Cichorium spinosum.
Journal of agricultural and food chemistry 2003;51(5):1289-92.
2003: Eleftherios Kalpoutzakis; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Sofia Mitakou
cis-Clerodane type diterpenes from Cistus monspeliensis.
Journal of natural products 2003;66(2):316-9.
2002: Nektarios Aligiannis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Harris Pratsinis
Synthesis and cytotoxic activity of a new potent daunomycinone derivative.
Bioorganic & medicinal chemistry letters 2002;12(24):3505-7.
2002: Sofia Pasi; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Ioanna Chinou
A new lignan glycoside and other constituents from Cephalaria ambrosioides.
Natural product letters 2002;16(6):365-70.
2002: Evagelia Harvala; Nektarios Aligiannis; Alexios-Leandros Skaltsounis; Harris Pratsinis; George Lambrinidis; Catherine Harvala; Ioanna Chinou
Cytotoxic germacranolides from Inula verbascifolia subsp. methanea.
Journal of natural products 2002;65(7):1045-8.
2002: Ioannis K Kostakis; Prokopios Magiatis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Harris Pratsinis; Stéphane Léonce; Alain Pierré
Design, synthesis, and antiproliferative activity of some new pyrazole-fused amino derivatives of the pyranoxanthenone, pyranothioxanthenone, and pyranoacridone ring systems: a new class of cytotoxic agents.
Journal of medicinal chemistry 2002;45(12):2599-609.
2002: George Kolokythas; Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Harris Pratsinis
Design and synthesis of some new pyranoxanthenone aminoderivatives with cytotoxic activity.
Bioorganic & medicinal chemistry letters 2002;12(11):1443-6.
2002: Elisabeth Seguin; Abdelhakim Elomri; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Lin Rui Chao; François Tillequin
Synthesis, dimerization, and biological activity of hexaoxygenated chalcones related to calythropsin and combretastatins.
Natural product letters 2002;16(3):187-93.
2002: Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Elisabeth Seguin; Jean-Pierre Cosson
Coelobillardin, an iridoid glucoside dimer from Coelospermum billardieri.
Phytochemistry 2002;60(4):415-8.
2002: Vasiliki Papandreou; Prokopios Magiatis; Ioanna Chinou; Eleftherios Kalpoutzakis; Alexios-Leandros Skaltsounis; ANTHONY TSARBOPOULOS
Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa.
Journal of ethnopharmacology 2002;81(1):101-4.
2002: Prokopios Magiatis; Alexios-Leandros Skaltsounis; Ioanna Chinou; Serkos A Haroutounian
Chemical composition and in-vitro antimicrobial activity of the essential oils of three Greek Achillea species.
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(3-4):287-90.
2002: Vasiliki Papandreou; Prokopios Magiatis; Eleftherios Kalpoutzakis; Alexios-Leandros Skaltsounis; Catherine Harvala
Paeonicluside, a new salicylic glycoside from the Greek endemic species Paeonia clusii.
Zeitschrift für Naturforschung. C, Journal of biosciences 2002;57(3-4):235-8.
2002: Nectarios Algiannis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Jean-Claude Florent; Elisabeth M Perchellet; Bonnie J Sperfslage; Corbin J McIlvain; Jean-Pierre H Perchellet
Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety.
The Journal of antibiotics 2002;55(2):181-90.
2001: S Paraschos; Prokopios Magiatis; Eleftherios Kalpoutzakis; Catherine Harvala; Alexios-Leandros Skaltsounis
Three new dihydroisocoumarins from the Greek endemic species Scorzonera cretica.
Journal of natural products 2001;64(12):1585-7.
2001: Elisabeth M Perchellet; Bonnie J Sperfslage; Corbin J McIlvain; Nektarios Aligiannis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Jean-Pierre H Perchellet
Antileukemic activity of synthetic daunomycinone derivatives bearing modifications in the glycosidic moiety.
Anticancer research 2001;21(6A):3957-67.
2001: Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Emmanuel Mikros; Alexios-Leandros Skaltsounis; stephane leonce; Ghanem Atassi; Pierre Renard
Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones.
Bioorganic & medicinal chemistry 2001;9(11):2793-802.
2001: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin
1-Oxo-2-hydroxy-1,2-dihydroacronycine: a useful synthon in the acronycine series for the introduction of amino substituents at 6-position and for the conversion into isopropylfuroacridones.
Chemical & pharmaceutical bulletin 2001;49(10):1304-7.
2001: Konstantinos M Kasiotis; Prokopios Magiatis; Harris Pratsinis; Alexios-Leandros Skaltsounis; V Abadji; A Charalambous; paraskevi moutsatsou; Serkos A Haroutounian
Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates.
Steroids 2001;66(10):785-91.
2001: I Kyriakopoulou; Prokopios Magiatis; Alexios-Leandros Skaltsounis; Nektarios Aligiannis; Catherine Harvala
Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia.
Journal of natural products 2001;64(8):1095-7.
2001: Eleftherios Kalpoutzakis; Nektarios Aligiannis; Sofia Mitaku; L Chinou; C Charvala; Alexios-Leandros Skaltsounis
New hemisynthetic manoyl oxide derivatives with antimicrobial activity.
Chemical & pharmaceutical bulletin 2001;49(7):814-7.
2001: Prokopios Magiatis; Harris Pratsinis; Eleftherios Kalpoutzakis; Anastasia E Konstantinidou; Panagiotis Davaris; Alexios-Leandros Skaltsounis
Hydrolyzable tannins, the active constituents of three Greek Cytinus taxa against several tumor cell lines.
Biological & pharmaceutical bulletin 2001;24(6):707-9.
2001: Eleni Melliou; Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; Alain Pierré; Ghanem Atassi; Pierre Renard
2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds.
Bioorganic & medicinal chemistry 2001;9(3):607-12.
2001: Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; E Vardala-Theodorou; ANTHONY TSARBOPOULOS
Homarine, a common metabolite in edible Mediterranean molluscs: occurrence, spectral data and revision of a related structure.
Natural product letters 2001;15(6):411-8.
2001: M Kotsos; Nektarios Aligiannis; Sofia Mitaku; Alexios-Leandros Skaltsounis; C Charvala
Chemistry of plants from Crete: stachyspinoside, a new flavonoid glycoside and iridoids from Stachys spinosa.
Natural product letters 2001;15(6):377-86.
2001: Y Ranarivelo; P Magiatis; Alexios-Leandros Skaltsounis; François Tillequin
Selective amination of secoiridoid glycosides to give monomeric pyridine, dimeric pyridine, and naphthyridine alkaloids.
Natural product letters 2001;15(2):131-7.
2001: Prokopios Magiatis; Antonios Michaelakis; Alexios-Leandros Skaltsounis; Serkos A Haroutounian
Volatile secondary metabolite pattern of callus cultures of Chamomilla recutita.
Natural product letters 2001;15(2):125-30.
2001: Eleftherios Kalpoutzakis; Nektarios Aligiannis; Sofia Mitaku; Ioanna Chinou; Catherine Harvala; Alexios-Leandros Skaltsounis
New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus.
Zeitschrift für Naturforschung. C, Journal of biosciences 2001;56(1-2):49-52.
2000: Maria Halabalaki; Nektarios Aligiannis; Zoi Papoutsi; Sofia Mitakou; paraskevi moutsatsou; Constantine E Sekeris; Alexios-Leandros Skaltsounis
Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.
Journal of natural products 2000;63(12):1672-4.
2000: Spyridon Karkabounas; Dimitrios Assimakopoulos; Michail Malamas; Alexios-Leandros Skaltsounis; stephane leonce; John Zelovitis; Dimitrios Stefanou; Angelos Evangelou
Antiproliferative and anticarcinogenic effects of an aqueous preparation of Abies alba and Viscum album se abies, on a L-1210 malignant cell line and tumor-bearing Wistar rats.
Anticancer research 2000;20(6B):4391-5.
2000: Nikolas Fokialakis; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
Megistolactone, a new alkaloid from Sarcomelicope megistophylla.
Zeitschrift für Naturforschung. C, Journal of biosciences 2000;55(11-12):874-6.
2000: Nikolas Fokialakis; Prokopios Magiatis; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
The structure of sarcomejine: an application of long-range (1)H-(15)N correlation at natural abundance.
Journal of natural products 2000;63(7):1004-5.
2000: Ioannis K Kostakis; K Ghirtis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; stephane leonce; Daniel-Henri Caignard; Ghanem Atassi
Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives.
Farmaco (Società chimica italiana : 1989) 2000;55(6-7):455-60.
2000: M Papageorgiou; Nikolas Fokialakis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Thierry Sévenet
Two new alkaloids from the bark of Sarcomelicope megistophylla.
Journal of natural products 2000;63(3):385-6.
2000: Helen Skaltsa; Paulina Bermejo; Diamanto Lazari; A M Silvan; Alexios-Leandros Skaltsounis; A Sanz; María José Abad
Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida.
Biological & pharmaceutical bulletin 2000;23(1):47-53.
2000: Nektarios Aligiannis; Nicole Pouli; Panagiotis Marakos; Sofia Mitaku; Alexios-Leandros Skaltsounis; stephane leonce; A Pierre; Ghanem Atassi
Design, synthesis and biological activity of 7-O-(4-O-acetyl-3-iodo-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl) daunomycinone and 7-O-(3-chloro-2,3,6-trideoxy-4-O-propanoyl-alpha-L-lyxo- hexopyranosyl)daunomycinone.
Chemical & pharmaceutical bulletin 2000;48(1):150-3.
1999: Nikolas Fokialakis; Sofia Mitaku; Emmanuel Mikros; Alexios-Leandros Skaltsounis; François Tillequin; T Sevenet
Megistosarcimine and megistosarconine, two alkaloids from Sarcomelicope megistophylla.
Phytochemistry 1999;52(8):1745-8.
1999: Prokopios Magiatis; Eleni Melliou; Alexios-Leandros Skaltsounis; Ioanna Chinou; Sofia Mitaku
Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. chia.
Planta medica 1999;65(8):749-52.
1999: D Mitrocotsa; S Bosch; Sofia Mitaku; C Dimas; Alexios-Leandros Skaltsounis; Catherine Harvala; G Briand; Christos Roussakis
Cytotoxicity against human leukemic cell lines, and the activity on the expression of resistance genes of flavonoids from Platanus orientalis.
Anticancer research 1999;19(3A):2085-8.
1999: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of 1-alkoxy- and 1-amino-2-hydroxy-1,2-dihydroacronycine derivatives.
Chemical & pharmaceutical bulletin 1999;47(5):611-4.
1999: Eleftherios Kalpoutzakis; Nektarios Aligiannis; Sofia Mitakou; Alexios-Leandros Skaltsounis
Verbaspinoside, a new iridoid glycoside from Verbascum spinosum.
Journal of natural products 1999;62(2):342-4.
1998: Prokopios Magiatis; Eleni Melliou; Alexios-Leandros Skaltsounis; Sofia Mitaku; S Léonce; Pierre Renard; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series.
Journal of natural products 1998;61(8):982-6.
1998: Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; Alain Pierré; Ghanem Atassi
Synthesis and biological activity of esters in the trans-1,2-dihydroxy-1,2-dihydroacronycine series.
Journal of natural products 1998;61(2):198-201.
1996: A Elomri; Sofia Mitaku; Sylvie Michel; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; Alain Pierré; Nicolas Guilbaud; Stéphane Léonce; Laurence Kraus-Berthier; Y Rolland; Ghanem Atassi
Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series.
Journal of medicinal chemistry 1996;39(24):4762-6.
1996: A Elomri; Alexios-Leandros Skaltsounis; Sylvie Michel; François Tillequin; Michel Koch; Y Rolland; Alain Pierré; Ghanem Atassi
Synthesis and cytotoxic activity of acronycine derivatives modified at the pyran ring.
Chemical & pharmaceutical bulletin 1996;44(11):2165-8.
1996: Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; Y Rolland; Alain Pierré; Ghanem Atassi
Synthesis and anti-proliferative activity of 2-hydroxy-1,2-dihydroacronycine glycosides.
Pharmaceutical research 1996;13(6):939-43.
1994: C Demetzos; Alexios-Leandros Skaltsounis; B Razanamahefa; François Tillequin
Synthesis of quercetin-3-O-beta-D-glucopyranosyl-(1-->2)-beta-D- xylopyranoside via orthoester methodology.
Journal of natural products 1994;57(9):1234-8.
1994: L K Basco; Sofia Mitaku; Alexios-Leandros Skaltsounis; N Ravelomanantsoa; François Tillequin; Michel Koch; J Le Bras
In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1994;38(5):1169-71.
1994: R C Lin; Alexios-Leandros Skaltsounis; Elisabeth Seguin; François Tillequin; Michel Koch
Phenolic Constituents of Selaginella doederleinii.
Planta medica 1994;60(2):168-70.
1994: C Demetzos; Alexios-Leandros Skaltsounis; Sylvie Michel; François Tillequin; Michel Koch; M Anstett; S Leonce; Alain Pierré; Ghanem Atassi
Synthesis and biological activity of 3'-deamino-3'-haloanthracyclines.
Anti-cancer drug design 1994;9(2):129-37.
1991: R Benkrief; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; J Pusset
Iridoids and an Alkaloid from Oxera morieri1.
Planta medica 1991;57(1):79-80.
1990: C Demetzos; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch
Phase-transfer-catalyzed synthesis of flavonoid glycosides.
Carbohydrate research 1990;207(1):131-7.
1990: Y Ranarivelo; Alexios-Leandros Skaltsounis; M Andriantsiferana; François Tillequin
[Glycosides from Mussaenda arcuata Lam. ex Poiret leaves].
Annales pharmaceutiques françaises 1990;48(5):273-7.
1989: Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch; J Pusset; G Chauvière
Iridoids from Scaevola racemigera1.
Planta medica 1989;55(2):191-2.
1989: Alexios-Leandros Skaltsounis; S Sbahi; C Demetzos; J Pusset
[Plants in New Caledonia. Iridoids from Scaevola montana Labill].
Annales pharmaceutiques françaises 1989;47(4):249-54.
1989: Sofia Mitaku; Alexios-Leandros Skaltsounis; François Tillequin; M Koch; J Pusset
[Plants from New Caledonia. Alkaloids from Sarcomelicope dogniensis Hartley stem bark].
Annales pharmaceutiques françaises 1989;47(3):149-56.
1989: A Papadaki-Valiraki; T Siatra-Papastaikoudi; Alexios-Leandros Skaltsounis; Christos Roussakis
[Synthesis of new nitrosoureas].
Annales pharmaceutiques françaises 1989;47(6):394-401.
1988: G Baudouin; Alexios-Leandros Skaltsounis; François Tillequin; Michel Koch
Lugrandoside: a new phenylpropanoid glycoside from various digitalis species.
Planta medica 1988;54(4):321-3.