Wolfram Bode

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TOP 3
Wisniewska Magdalena; Goettig Peter; Maskos Klaus; Belouski Edward; Winters Dwight; Hecht Randy; Black Roy; Bode Wolfram
Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Pallarès Irantzu; Fernández Daniel; Comellas-Bigler Mireia; Fernández-Recio Juan; Ventura Salvador; Avilés Francesc X; Bode Wolfram; Vendrell Josep
Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Debela Mekdes; Beaufort Nathalie; Magdolen Viktor; Schechter Norman M; Craik Charles S; Schmitt Manfred; Bode Wolfram; Goettig Peter
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

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All Publications

2008: Wisniewska Magdalena; Goettig Peter; Maskos Klaus; Belouski Edward; Winters Dwight; Hecht Randy; Black Roy; Bode Wolfram
Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Journal of molecular biology 2008;381(5):1307-19.
2008: Pallarès Irantzu; Fernández Daniel; Comellas-Bigler Mireia; Fernández-Recio Juan; Ventura Salvador; Avilés Francesc X; Bode Wolfram; Vendrell Josep
Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):784-91.
2008: Debela Mekdes; Beaufort Nathalie; Magdolen Viktor; Schechter Norman M; Craik Charles S; Schmitt Manfred; Bode Wolfram; Goettig Peter
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
Biological chemistry 2008;389(6):623-32.
2008: Friedrich Rainer; Riester Daniel; Göttig Peter; Thürk Marcel; Schwienhorst Andreas; Bode Wolfram
Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue.
European journal of medicinal chemistry 2008;43(6):1330-5.
2007: Barazza Alessandra; Götz Marion; Cadamuro Sergio A; Goettig Peter; Willem Michael; Steuber Holger; Kohler Tanja; Jestel Anja; Reinemer Peter; Renner Christian; Bode Wolfram; Moroder Luis
Macrocyclic statine-based inhibitors of BACE-1.
Chembiochem : a European journal of chemical biology 2007;8(17):2078-91.
2007: Debela Mekdes; Goettig Peter; Magdolen Viktor; Huber Robert; Schechter Norman M; Bode Wolfram
Structural basis of the zinc inhibition of human tissue kallikrein 5.
Journal of molecular biology 2007;373(4):1017-31.
2007: Debela Mekdes; Hess Petra; Magdolen Viktor; Schechter Norman M; Steiner Thomas; Huber Robert; Bode Wolfram; Goettig Peter
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16086-91.
2007: Tochowicz Anna; Maskos Klaus; Huber Robert; Oltenfreiter Ruth; Dive Vincent; Yiotakis Athanasios; Zanda Matteo; Pourmotabbed Tayebeh; Bode Wolfram; Goettig Peter
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.
Journal of molecular biology 2007;371(4):989-1006.
2007: Maskos K; Lang R; Tschesche H; Bode W
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.
Journal of molecular biology 2007;366(4):1222-31.
2007: Keil Cora; Maskos Klaus; Than Manuel; Hoopes J Todd; Huber Robert; Tan Fulong; Deddish Peter A; Erdös Ervin G; Skidgel Randal A; Bode Wolfram
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
Journal of molecular biology 2007;366(2):504-16.
2006: Debela Mekdes; Magdolen Viktor; Grimminger Valerie; Sommerhoff Christian; Messerschmidt Albrecht; Huber Robert; Friedrich Rainer; Bode Wolfram; Goettig Peter
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.
Journal of molecular biology 2006;362(5):1094-107.
2006: Debela Mekdes; Magdolen Viktor; Schechter Norman; Valachova Martina; Lottspeich Friedrich; Craik Charles S; Choe Youngchool; Bode Wolfram; Goettig Peter
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.
The Journal of biological chemistry 2006;281(35):25678-88.
2006: Steinmetzer Torsten; Schweinitz Andrea; Stürzebecher Anne; Dönnecke Daniel; Uhland Kerstin; Schuster Oliver; Steinmetzer Peter; Müller Friedemann; Friedrich Rainer; Than Manuel E; Bode Wolfram; Stürzebecher Jörg
Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.
Journal of medicinal chemistry 2006;49(14):4116-26.
2006: Bode Wolfram
The structure of thrombin: a janus-headed proteinase.
Seminars in thrombosis and hemostasis 2006;32 Suppl 1():16-31.
2006: Bode Wolfram
Structure and interaction modes of thrombin.
Blood cells, molecules & diseases 2006;36(2):122-30.
2006: Rohr Kerstin B; Selwood Trevor; Marquardt Ulf; Huber Robert; Schechter Norman M; Bode Wolfram; Than Manuel E
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
Journal of molecular biology 2006;357(1):195-209.
2006: Beaufort Nathalie; Debela Mekdes; Creutzburg Sabine; Kellermann Josef; Bode Wolfram; Schmitt Manfred; Pidard Dominique; Magdolen Viktor
Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).
Biological chemistry 2006;387(2):217-22.
2006: Engel Michael; Hoffmann Torsten; Manhart Susanne; Heiser Ulrich; Chambre Sylvie; Huber Robert; Demuth Hans-Ulrich; Bode Wolfram
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
Journal of molecular biology 2006;355(4):768-83.
2006: Panizzi Peter; Friedrich Rainer; Fuentes-Prior Pablo; Kroh Heather K; Briggs Judy; Tans Guido; Bode Wolfram; Bock Paul E
Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.
The Journal of biological chemistry 2006;281(2):1169-78.
2006: Panizzi Peter; Friedrich Rainer; Fuentes-Prior Pablo; Richter Klaus; Bock Paul E; Bode Wolfram
Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes.
The Journal of biological chemistry 2006;281(2):1179-87.
2006: Friedrich Rainer; Panizzi Peter; Kawabata Shun-Ichiro; Bode Wolfram; Bock Paul E; Fuentes-Prior Pablo
Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation.
The Journal of biological chemistry 2006;281(2):1188-95.
2005: Bayés Alex; Comellas-Bigler Mireia; Rodríguez de la Vega Monica; Maskos Klaus; Bode Wolfram; Aviles Francesc X; Jongsma Maarten A; Beekwilder Jules; Vendrell Josep
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16602-7.
2005: Bode W
The structure of thrombin, a chameleon-like proteinase.
Journal of thrombosis and haemostasis : JTH 2005;3(11):2379-88.
2005: Kacprzak Magdalena M; Than Manuel E; Juliano Luiz; Juliano Maria A; Bode Wolfram; Lindberg Iris
Mutations of the PC2 substrate binding pocket alter enzyme specificity.
The Journal of biological chemistry 2005;280(36):31850-8.
2005: Than Manuel E; Bourenkov Gleb P; Henrich Stefan; Mann Karlheinz; Bode Wolfram
The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist?
Biological chemistry 2005;386(8):759-66.
2005: Riester Daniel; Wirsching Frank; Salinas Gabriela; Keller Martina; Gebinoga Michael; Kamphausen Stefan; Merkwirth Christian; Goetz Ruediger; Wiesenfeldt Martin; Stürzebecher Jörg; Bode Wolfram; Friedrich Rainer; Thürk Marcel; Schwienhorst Andreas
Thrombin inhibitors identified by computer-assisted multiparameter design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8597-602.
2005: Comellas-Bigler M; Lang R; Bode W; Maskos K
Crystal structure of the E. coli dipeptidyl carboxypeptidase Dcp: further indication of a ligand-dependent hinge movement mechanism.
Journal of molecular biology 2005;349(1):99-112.
2005: Than Manuel E; Henrich Stefan; Bourenkov Gleb P; Bartunik Hans D; Huber Robert; Bode Wolfram
The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):505-12.
2005: Jozic Daniela; Bourenkov Gleb; Lim Ngee-Han; Visse Robert; Nagase Hideaki; Bode Wolfram; Maskos Klaus
X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
The Journal of biological chemistry 2005;280(10):9578-85.
2005: Henrich Stefan; Lindberg Iris; Bode Wolfram; Than Manuel E
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity.
Journal of molecular biology 2005;345(2):211-27.
2004: Panizzi P; Friedrich R; Fuentes-Prior P; Bode W; Bock P E
The staphylocoagulase family of zymogen activator and adhesion proteins.
Cellular and molecular life sciences : CMLS 2004;61(22):2793-8.
2004: Keil Cora; Huber Robert; Bode Wolfram; Than Manuel E
Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1614-7.
2004: Kacprzak Magdalena M; Peinado Juan R; Than Manuel E; Appel Jon; Henrich Stefan; Lipkind Gregory; Houghten Richard A; Bode Wolfram; Lindberg Iris
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.
The Journal of biological chemistry 2004;279(35):36788-94.
2004: Comellas-Bigler Mireia; Maskos Klaus; Huber Robert; Oyama Hiroshi; Oda Kohei; Bode Wolfram
1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase.
Structure (London, England : 1993) 2004;12(7):1313-23.
2004: Reverter David; Maskos Klaus; Tan Fulong; Skidgel Randal A; Bode Wolfram
Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.
Journal of molecular biology 2004;338(2):257-69.
2004: Lang R; Braun M; Sounni N E; Noel A; Frankenne F; Foidart J-M; Bode W; Maskos K
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features.
Journal of molecular biology 2004;336(1):213-25.
2004: Saleh Mahasen; Peng Weimin; Quinn-Allen Mary Ann; Macedo-Ribeiro Sandra; Fuentes-Prior Pablo; Bode Wolfram; Kane William H
The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.
Thrombosis and haemostasis 2004;91(1):16-27.
2003: Maskos Klaus; Bode Wolfram
Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases.
Molecular biotechnology 2003;25(3):241-66.
2003: Friedrich Rainer; Panizzi Peter; Fuentes-Prior Pablo; Richter Klaus; Verhamme Ingrid; Anderson Patricia J; Kawabata Shun-Ichiro; Huber Robert; Bode Wolfram; Bock Paul E
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.
Nature 2003;425(6957):535-9.
2003: Jozic Daniela; Kaiser Jens T; Huber Robert; Bode Wolfram; Maskos Klaus
X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases.
Journal of molecular biology 2003;332(1):243-56.
2003: Henrich Stefan; Cameron Angus; Bourenkov Gleb P; Kiefersauer Reiner; Huber Robert; Lindberg Iris; Bode Wolfram; Than Manuel E
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Nature structural biology 2003;10(7):520-6.
2003: Bode Wolfram; Maskos Klaus
Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases.
Biological chemistry 2003;384(6):863-72.
2003: Engel Michael; Hoffmann Torsten; Wagner Leona; Wermann Michael; Heiser Ulrich; Kiefersauer Reiner; Huber Robert; Bode Wolfram; Demuth Hans-Ulrich; Brandstetter Hans
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5063-8.
2003: Zeslawska Ewa; Jacob Uwe; Schweinitz Andrea; Coombs Gary; Bode Wolfram; Madison Edwin
Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors.
Journal of molecular biology 2003;328(1):109-18.
2003: Sichler Katrin; Kopetzki Erhard; Huber Robert; Bode Wolfram; Hopfner Karl-Peter; Brandstetter Hans
Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop.
The Journal of biological chemistry 2003;278(6):4121-6.
2003: Volpicella Mariateresa; Ceci Luigi R; Cordewener Jan; America Twan; Gallerani Raffaele; Bode Wolfram; Jongsma Maarten A; Beekwilder Jules
Properties of purified gut trypsin from Helicoverpa zea, adapted to proteinase inhibitors.
European journal of biochemistry / FEBS 2003;270(1):10-9.
2003: Bode Wolfram
Structural basis of matrix metalloproteinase function.
Biochemical Society symposium 2003;(70):1-14.
2002: Sichler Katrin; Hopfner Karl Peter; Kopetzki Erhard; Huber Robert; Bode Wolfram; Brandstetter Hans
The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved.
FEBS letters 2002;530(1-3):220-4.
2002: Reverter David; Braun Marianne; Fernandez-Catalan Carlos; Strobl Stefan; Sorimachi Hiroyuki; Bode Wolfram
Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain.
Biological chemistry 2002;383(9):1415-22.
2002: Sichler Katrin; Banner David W; D'Arcy Allan; Hopfner Karl-Peter; Huber Robert; Bode Wolfram; Kresse Georg-Burkhard; Kopetzki Erhard; Brandstetter Hans
Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.
Journal of molecular biology 2002;322(3):591-603.
2002: Jozic Daniela; Bourenkow Gleb; Bartunik Hans; Scholze Henning; Dive Vincent; Henrich Bernhard; Huber Robert; Bode Wolfram; Maskos Klaus
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides.
Structure (London, England : 1993) 2002;10(8):1097-106.
2002: Marquardt Ulf; Zettl Frank; Huber Robert; Bode Wolfram; Sommerhoff Christian
The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region.
Journal of molecular biology 2002;321(3):491-502.
2002: Mueller Markus Michael; Sperl Stefan; Stürzebecher Jörg; Bode Wolfram; Moroder Luis
(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.
Biological chemistry 2002;383(7-8):1185-91.
2002: Comellas-Bigler Mireia; Fuentes-Prior Pablo; Maskos Klaus; Huber Robert; Oyama Hiroshi; Uchida Kenichi; Dunn Ben M; Oda Kohei; Bode Wolfram
The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase.
Structure (London, England : 1993) 2002;10(6):865-76.
2002: Than Manuel E; Henrich Stefan; Huber Robert; Ries Albert; Mann Karlheinz; Kühn Klaus; Timpl Rupert; Bourenkov Gleb P; Bartunik Hans D; Bode Wolfram
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6607-12.
2002: Friedrich Rainer; Steinmetzer Torsten; Huber Robert; Stürzebecher Jörg; Bode Wolfram
The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
Journal of molecular biology 2002;316(4):869-74.
2002: Richardson John L; Fuentes-Prior Pablo; Sadler J Evan; Huber Robert; Bode Wolfram
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.
Biochemistry 2002;41(8):2535-42.
2002: Friedrich Rainer; Fuentes-Prior Pablo; Ong Edgar; Coombs Gary; Hunter Michael; Oehler Ryan; Pierson Diane; Gonzalez Richard; Huber Robert; Bode Wolfram; Madison Edwin L
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase.
The Journal of biological chemistry 2002;277(3):2160-8.
2001: Riedl S J; Fuentes-Prior P; Renatus M; Kairies N; Krapp S; Huber R; Salvesen G S; Bode W
Structural basis for the activation of human procaspase-7.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14790-5.
2001: Kairies N; Beisel H G; Fuentes-Prior P; Tsuda R; Muta T; Iwanaga S; Bode W; Huber R; Kawabata S
The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13519-24.
2001: Estébanez-Perpiñá E; Bayés A; Vendrell J; Jongsma M A; Bown D P; Gatehouse J A; Huber R; Bode W; Avilés F X; Reverter D
Crystal structure of a novel mid-gut procarboxypeptidase from the cotton pest Helicoverpa armigera.
Journal of molecular biology 2001;313(3):629-38.
2001: Lang R; Kocourek A; Braun M; Tschesche H; Huber R; Bode W; Maskos K
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
Journal of molecular biology 2001;312(4):731-42.
2001: Reverter D; Sorimachi H; Bode W
The structure of calcium-free human m-calpain: implications for calcium activation and function.
Trends in cardiovascular medicine 2001;11(6):222-9.
2001: Rester U; Bode W; Sampaio C A; Auerswald E A; Lopes A P
Cloning, purification, crystallization and preliminary X-ray diffraction analysis of the antistasin-type inhibitor ghilanten (domain I) from Haementeria ghilianii in complex with porcine beta-trypsin.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 7):1038-41.
2001: Izumi T; Kim S W; Greist A; Macedo-Ribeiro S; Fuentes-Prior P; Bode W; Kane W H; Ortel T L
Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding.
Thrombosis and haemostasis 2001;85(6):1048-54.
2001: Reverter D; Strobl S; Fernandez-Catalan C; Sorimachi H; Suzuki K; Bode W
Structural basis for possible calcium-induced activation mechanisms of calpains.
Biological chemistry 2001;382(5):753-66.
2001: Brandstetter H; Grams F; Glitz D; Lang A; Huber R; Bode W; Krell H W; Engh R A
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
The Journal of biological chemistry 2001;276(20):17405-12.
2001: Schaschke N; Matschiner G; Zettl F; Marquardt U; Bergner A; Bode W; Sommerhoff C P; Moroder L
Bivalent inhibition of human beta-tryptase.
Chemistry & biology 2001;8(4):313-27.
2001: Kawabata S; Beisel H G; Huber R; Bode W; Gokudan S; Muta T; Tsuda R; Koori K; Kawahara T; Seki N; Mizunoe Y; Wai S N; Iwanaga S
Role of tachylectins in host defense of the Japanese horseshoe crab Tachypleus tridentatus.
Advances in experimental medicine and biology 2001;484():195-202.
2001: Bode W; Maskos K
Structural studies on MMPs and TIMPs.
Methods in molecular biology (Clifton, N.J.) 2001;151():45-77.
2000: Estébanez-Perpiña E; Fuentes-Prior P; Belorgey D; Braun M; Kiefersauer R; Maskos K; Huber R; Rubin H; Bode W
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.
Biological chemistry 2000;381(12):1203-14.
2000: Richardson J L; Kröger B; Hoeffken W; Sadler J E; Pereira P; Huber R; Bode W; Fuentes-Prior P
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.
The EMBO journal 2000;19(21):5650-60.
2000: Sperl S; Jacob U; Arroyo de Prada N; Stürzebecher J; Wilhelm O G; Bode W; Magdolen V; Huber R; Moroder L
(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5113-8.
2000: Rester U; Moser M; Huber R; Bode W
L-Isoaspartate 115 of porcine beta-trypsin promotes crystallization of its complex with bdellastasin.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 5):581-8.
2000: Sperl S; Bergner A; Stürzebecher J; Magdolen V; Bode W; Moroder L
Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
Biological chemistry 2000;381(4):321-9.
2000: Reverter D; Fernández-Catalán C; Baumgartner R; Pfänder R; Huber R; Bode W; Vendrell J; Holak T A; Avilés F X
Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nature structural biology 2000;7(4):322-8.
2000: Fuentes-Prior P; Iwanaga Y; Huber R; Pagila R; Rumennik G; Seto M; Morser J; Light D R; Bode W
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Nature 2000;404(6777):518-25.
2000: Bode W; Huber R
Structural basis of the endoproteinase-protein inhibitor interaction.
Biochimica et biophysica acta 2000;1477(1-2):241-52.
2000: Sommerhoff C P; Bode W; Matschiner G; Bergner A; Fritz H
The human mast cell tryptase tetramer: a fascinating riddle solved by structure.
Biochimica et biophysica acta 2000;1477(1-2):75-89.
2000: Kim S W; Quinn-Allen M A; Camp J T; Macedo-Ribeiro S; Fuentes-Prior P; Bode W; Kane W H
Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis.
Biochemistry 2000;39(8):1951-8.
2000: Ottl J; Gabriel D; Murphy G; Knäuper V; Tominaga Y; Nagase H; Kröger M; Tschesche H; Bode W; Moroder L
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.
Chemistry & biology 2000;7(2):119-32.
2000: Masumoto H; Nakagawa K; Irie S; Sorimachi H; Suzuki K; Bourenkov G P; Bartunik H; Fernandez-Catalan C; Bode W; Strobl S
Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 1):73-5.
2000: Strobl S; Fernandez-Catalan C; Braun M; Huber R; Masumoto H; Nakagawa K; Irie A; Sorimachi H; Bourenkow G; Bartunik H; Suzuki K; Bode W
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):588-92.
1999: Macedo-Ribeiro S; Bode W; Huber R; Quinn-Allen M A; Kim S W; Ortel T L; Bourenkov G P; Bartunik H D; Stubbs M T; Kane W H; Fuentes-Prior P
Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
Nature 1999;402(6760):434-9.
1999: Eichinger A; Beisel H G; Jacob U; Huber R; Medrano F J; Banbula A; Potempa J; Travis J; Bode W
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
The EMBO journal 1999;18(20):5453-62.
1999: Rester U; Bode W; Moser M; Parry M A; Huber R; Auerswald E
Structure of the complex of the antistasin-type inhibitor bdellastasin with trypsin and modelling of the bdellastasin-microplasmin system.
Journal of molecular biology 1999;293(1):93-106.
1999: Steinmetzer T; Renatus M; Künzel S; Eichinger A; Bode W; Wikström P; Hauptmann J; Stürzebecher J
Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.
European journal of biochemistry / FEBS 1999;265(2):598-605.
1999: Pereira P J; Lozanov V; Patthy A; Huber R; Bode W; Pongor S; Strobl S
Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution.
Structure (London, England : 1993) 1999;7(9):1079-88.
1999: Sommerhoff C P; Bode W; Pereira P J; Stubbs M T; Stürzebecher J; Piechottka G P; Matschiner G; Bergner A
The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10984-91.
1999: Hopfner K P; Lang A; Karcher A; Sichler K; Kopetzki E; Brandstetter H; Huber R; Bode W; Engh R A
Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Structure (London, England : 1993) 1999;7(8):989-96.
1999: Bode W; Fernandez-Catalan C; Grams F; Gomis-Rüth F X; Nagase H; Tschesche H; Maskos K
Insights into MMP-TIMP interactions.
Annals of the New York Academy of Sciences 1999;878():73-91.
1999: Nagase H; Meng Q; Malinovskii V; Huang W; Chung L; Bode W; Maskos K; Brew K
Engineering of selective TIMPs.
Annals of the New York Academy of Sciences 1999;878():1-11.
1999: Beisel H G; Kawabata S; Iwanaga S; Huber R; Bode W
Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus.
The EMBO journal 1999;18(9):2313-22.
1999: Bode W; Fernandez-Catalan C; Tschesche H; Grams F; Nagase H; Maskos K
Structural properties of matrix metalloproteinases.
Cellular and molecular life sciences : CMLS 1999;55(4):639-52.
1999: Meng Q; Malinovskii V; Huang W; Hu Y; Chung L; Nagase H; Bode W; Maskos K; Brew K
Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate.
The Journal of biological chemistry 1999;274(15):10184-9.
1999: Pereira P J; Wang Z M; Rubin H; Huber R; Bode W; Schechter N M; Strobl S
The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.
Journal of molecular biology 1999;286(1):163-73.
1999: Bode W; Fernandez-Catalan C; Nagase H; Maskos K
Endoproteinase-protein inhibitor interactions.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):3-10.
1998: Renatus M; Bode W; Huber R; Stürzebecher J; Stubbs M T
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Journal of medicinal chemistry 1998;41(27):5445-56.
1998: Tuuttila A; Morgunova E; Bergmann U; Lindqvist Y; Maskos K; Fernandez-Catalan C; Bode W; Tryggvason K; Schneider G
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.
Journal of molecular biology 1998;284(4):1133-40.
1998: Gabriel B; Stubbs M T; Bergner A; Hauptmann J; Bode W; Stürzebecher J; Moroder L
Design of benzamidine-type inhibitors of factor Xa.
Journal of medicinal chemistry 1998;41(22):4240-50.
1998: Parry M A; Fernandez-Catalan C; Bergner A; Huber R; Hopfner K P; Schlott B; Gührs K H; Bode W
The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action.
Nature structural biology 1998;5(10):917-23.
1998: Parry M A; Jacob U; Huber R; Wisner A; Bon C; Bode W
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases.
Structure (London, England : 1993) 1998;6(9):1195-206.
1998: Banbula A; Potempa J; Travis J; Fernandez-Catalán C; Mann K; Huber R; Bode W; Medrano F
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution.
Structure (London, England : 1993) 1998;6(9):1185-93.
1998: Fernandez-Catalan C; Bode W; Huber R; Turk D; Calvete J J; Lichte A; Tschesche H; Maskos K
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
The EMBO journal 1998;17(17):5238-48.
1998: Hopfner K P; Kopetzki E; Kresse G B; Bode W; Huber R; Engh R A
New enzyme lineages by subdomain shuffling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9813-8.
1998: Graf von Roedern E; Brandstetter H; Engh R A; Bode W; Grams F; Moroder L
Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8).
Journal of medicinal chemistry 1998;41(16):3041-7.
1998: Brandstetter H; Engh R A; Von Roedern E G; Moroder L; Huber R; Bode W; Grams F
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein science : a publication of the Protein Society 1998;7(6):1303-9.
1998: Banbula A; Potempa J; Travis J; Bode W; Medrano F J
Crystallization and preliminary X-ray diffraction analysis of gingipain R2 from Porphyromonas gingivalis in complex with H-D-Phe-Phe-Arg-chloromethylketone.
Protein science : a publication of the Protein Society 1998;7(5):1259-61.
1998: Pereira P J; Bergner A; Macedo-Ribeiro S; Huber R; Matschiner G; Fritz H; Sommerhoff C P; Bode W
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
Nature 1998;392(6673):306-11.
1998: Maskos K; Fernandez-Catalan C; Huber R; Bourenkov G P; Bartunik H; Ellestad G A; Reddy P; Wolfson M F; Rauch C T; Castner B J; Davis R; Clarke H R; Petersen M; Fitzner J N; Cerretti D P; March C J; Paxton R J; Black R A; Bode W
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3408-12.
1998: Stubbs M T; Renatus M; Bode W
An active zymogen: unravelling the mystery of tissue-type plasminogen activator.
Biological chemistry 1998;379(2):95-103.
1998: Medrano F J; Alonso J; García J L; Romero A; Bode W; Gomis-Rüth F X
Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family.
The EMBO journal 1998;17(1):1-9.
1997: Bode W; Renatus M
Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function.
Current opinion in structural biology 1997;7(6):865-72.
1997: Hopfner K P; Brandstetter H; Karcher A; Kopetzki E; Huber R; Engh R A; Bode W
Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants.
The EMBO journal 1997;16(22):6626-35.
1997: Renatus M; Stubbs M T; Huber R; Bringmann P; Donner P; Schleuning W D; Bode W
Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.
Biochemistry 1997;36(44):13483-93.
1997: Fuentes-Prior P; Noeske-Jungblut C; Donner P; Schleuning W D; Huber R; Bode W
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11845-50.
1997: Gomis-Rüth F X; Maskos K; Betz M; Bergner A; Huber R; Suzuki K; Yoshida N; Nagase H; Brew K; Bourenkov G P; Bartunik H; Bode W
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature 1997;389(6646):77-81.
1997: Renatus M; Engh R A; Stubbs M T; Huber R; Fischer S; Kohnert U; Bode W
Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
The EMBO journal 1997;16(16):4797-805.
1997: Renatus M; Bode W; Huber R; Stürzebecher J; Prasa D; Fischer S; Kohnert U; Stubbs M T
Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
The Journal of biological chemistry 1997;272(35):21713-9.
1997: Stubbs M T; Morenweiser R; Stürzebecher J; Bauer M; Bode W; Huber R; Piechottka G P; Matschiner G; Sommerhoff C P; Fritz H; Auerswald E A
The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.
The Journal of biological chemistry 1997;272(32):19931-7.
1997: Sturzebecher J; Kopetzki E; Bode W; Hopfner K P
Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols.
FEBS letters 1997;412(2):295-300.
1997: Betz M; Huxley P; Davies S J; Mushtaq Y; Pieper M; Tschesche H; Bode W; Gomis-Rüth F X
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
European journal of biochemistry / FEBS 1997;247(1):356-63.
1997: Bode W; Brandstetter H; Mather T; Stubbs M T
Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C.
Thrombosis and haemostasis 1997;78(1):501-11.
1997: Gomis-Rüth F X; Gómez-Ortiz M; Vendrell J; Ventura S; Bode W; Huber R; Avilés F X
Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation.
Journal of molecular biology 1997;269(5):861-80.
1997: van de Locht A; Bode W; Huber R; Le Bonniec B F; Stone S R; Esmon C T; Stubbs M T
The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.
The EMBO journal 1997;16(11):2977-84.
1997: Bergner A; Muta T; Iwanaga S; Beisel H G; Delotto R; Bode W
Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain.
Biological chemistry 1997;378(3-4):283-7.
1997: Medrano F J; Alonso J; García J L; Bode W; Gomis-Rüth F X
Crystallization and preliminary X-ray diffraction analysis of proline iminopeptidase from Xanthomonas campestris pv. citri.
FEBS letters 1997;400(1):91-3.
1996: Mather T; Oganessyan V; Hof P; Huber R; Foundling S; Esmon C; Bode W
The 2.8 A crystal structure of Gla-domainless activated protein C.
The EMBO journal 1996;15(24):6822-31.
1996: Bergner A; Oganessyan V; Muta T; Iwanaga S; Typke D; Huber R; Bode W
Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.
The EMBO journal 1996;15(24):6789-97.
1996: Gomis-Rüth F X; Gohlke U; Betz M; Knäuper V; Murphy G; López-Otín C; Bode W
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.
Journal of molecular biology 1996;264(3):556-66.
1996: van de Locht A; Stubbs M T; Bode W; Friedrich T; Bollschweiler C; Höffken W; Huber R
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
The EMBO journal 1996;15(22):6011-7.
1996: Ottl J; Battistuta R; Pieper M; Tschesche H; Bode W; Kühn K; Moroder L
Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot. Models for collagen catabolism by matrix-metalloproteases.
FEBS letters 1996;398(1):31-6.
1996: Brandstetter H; Kühne A; Bode W; Huber R; von der Saal W; Wirthensohn K; Engh R A
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition.
The Journal of biological chemistry 1996;271(47):29988-92.
1996: Engh R A; Brandstetter H; Sucher G; Eichinger A; Baumann U; Bode W; Huber R; Poll T; Rudolph R; von der Saal W
Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.
Structure (London, England : 1993) 1996;4(11):1353-62.
1996: Hof P; Mayr I; Huber R; Korzus E; Potempa J; Travis J; Powers J C; Bode W
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
The EMBO journal 1996;15(20):5481-91.
1996: Grams F; Dive V; Yiotakis A; Yiallouros I; Vassiliou S; Zwilling R; Bode W; Stöcker W
Structure of astacin with a transition-state analogue inhibitor.
Nature structural biology 1996;3(8):671-5.
1996: Lamba D; Bauer M; Huber R; Fischer S; Rudolph R; Kohnert U; Bode W
The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.
Journal of molecular biology 1996;258(1):117-35.
1996: van de Locht A; Stubbs M T; Bauer M; Bode W
Crystallographic evidence that the F2 kringle catalytic domain linker of prothrombin does not cover the fibrinogen recognition exosite.
The Journal of biological chemistry 1996;271(7):3413-6.
1996: Gohlke U; Gomis-Rüth F X; Crabbe T; Murphy G; Docherty A J; Bode W
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
FEBS letters 1996;378(2):126-30.
1996: Bode W; Grams F; Reinemer P; Gomis-Rüth F X; Baumann U; McKay D B; Stöcker W
The metzincin-superfamily of zinc-peptidases.
Advances in experimental medicine and biology 1996;389():1-11.
1995: Engh R A; Huber R; Bode W; Schulze A J
Divining the serpin inhibition mechanism: a suicide substrate 'springe'?
Trends in biotechnology 1995;13(12):503-10.
1995: Stubbs M T; Huber R; Bode W
Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS letters 1995;375(1-2):103-7.
1995: van de Locht A; Lamba D; Bauer M; Huber R; Friedrich T; Kröger B; Höffken W; Bode W
Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
The EMBO journal 1995;14(21):5149-57.
1995: Grams F; Crimmin M; Hinnes L; Huxley P; Pieper M; Tschesche H; Bode W
Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Biochemistry 1995;34(43):14012-20.
1995: Brandstetter H; Bauer M; Huber R; Lollar P; Bode W
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9796-800.
1995: Bode W
A helping hand for collagenases: the haemopexin-like domain.
Structure (London, England : 1993) 1995;3(6):527-30.
1995: Stöcker W; Bode W
Structural features of a superfamily of zinc-endopeptidases: the metzincins.
Current opinion in structural biology 1995;5(3):383-90.
1995: Stöcker W; Grams F; Baumann U; Reinemer P; Gomis-Rüth F X; McKay D B; Bode W
The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases.
Protein science : a publication of the Protein Society 1995;4(5):823-40.
1995: Turk D; Podobnik M; Popovic T; Katunuma N; Bode W; Huber R; Turk V
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.
Biochemistry 1995;34(14):4791-7.
1995: Grams F; Reinemer P; Powers J C; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
European journal of biochemistry / FEBS 1995;228(3):830-41.
1994: Stubbs M T; Bode W
Coagulation factors and their inhibitors.
Current opinion in structural biology 1994;4(6):823-32.
1994: Tschesche H; Bläser J; Kleine T; Schnierer S; Reinemer P; Bode W; Maasjoshusmann U; Fricke C
Inhibition of matrix metalloproteinases in rheumatoid arthritis and the crystallographic binding mode of a peptide inhibitor.
Annals of the New York Academy of Sciences 1994;732():400-2.
1994: Zhang D; Botos I; Gomis-Rüth F X; Doll R; Blood C; Njoroge F G; Fox J W; Bode W; Meyer E F
Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8447-51.
1994: Bode W; Kress L F; Meyer E F; Gomis-Rüth F X
The crystal structure of adamalysin II, a zinc-endopeptidase from the snake venom of the eastern diamondback rattlesnake Crotalus adamanteus.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(8):2049-68.
1994: Gomis-Rüth F X; Kress L F; Kellermann J; Mayr I; Lee X; Huber R; Bode W
Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin.
Journal of molecular biology 1994;239(4):513-44.
1994: Gomis-Rüth F X; Grams F; Yiallouros I; Nar H; Küsthardt U; Zwilling R; Bode W; Stöcker W
Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.
The Journal of biological chemistry 1994;269(25):17111-7.
1994: Schulze A J; Huber R; Bode W; Engh R A
Structural aspects of serpin inhibition.
FEBS letters 1994;344(2-3):117-24.
1994: Bode W; Reinemer P; Huber R; Kleine T; Schnierer S; Tschesche H
The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
The EMBO journal 1994;13(6):1263-9.
1994: Reinemer P; Grams F; Huber R; Kleine T; Schnierer S; Piper M; Tschesche H; Bode W
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS letters 1994;338(2):227-33.
1993: Engh R A; Dieckmann T; Bode W; Auerswald E A; Turk V; Huber R; Oschkinat H
Conformational variability of chicken cystatin. Comparison of structures determined by X-ray diffraction and NMR spectroscopy.
Journal of molecular biology 1993;234(4):1060-9.
1993: Engh R A; Schulze A J; Huber R; Bode W
Serpin structures.
Behring Institute Mitteilungen 1993;(93):41-62.
1993: Grams F; Huber R; Kress L F; Moroder L; Bode W
Activation of snake venom metalloproteinases by a cysteine switch-like mechanism.
FEBS letters 1993;335(1):76-80.
1993: Gomis-Rüth F X; Kress L F; Bode W
First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.
The EMBO journal 1993;12(11):4151-7.
1993: Bode W; Gomis-Rüth F X; Stöckler W
Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'.
FEBS letters 1993;331(1-2):134-40.
1993: Stöcker W; Gomis-Rüth F X; Bode W; Zwilling R
Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases.
European journal of biochemistry / FEBS 1993;214(1):215-31.
1993: Gomis-Rüth F X; Stöcker W; Huber R; Zwilling R; Bode W
Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin.
Journal of molecular biology 1993;229(4):945-68.
1993: Bode W
X-ray crystal structures of thrombin in complex with D-Phe-Pro-Arg and with small benzamidine- and arginine-based "non-peptidic" inhibitors.
Advances in experimental medicine and biology 1993;340():15-26.
1993: Bauer M; Brandstetter H; Turk D; Stürzebecher J; Bode W
Crystallographic determination of thrombin complexes with small synthetic inhibitors as a starting point for the receptor-based design of antithrombotics.
Seminars in thrombosis and hemostasis 1993;19(4):352-60.
1993: Stubbs M T; Bode W
A model for the specificity of fibrinogen cleavage by thrombin.
Seminars in thrombosis and hemostasis 1993;19(4):344-51.
1993: Karshikov A; Bode W
Electrostatic properties of thrombin: importance for structural stabilization and ligand binding.
Seminars in thrombosis and hemostasis 1993;19(4):334-43.
1993: Bode W; Stubbs M T
Spatial structure of thrombin as a guide to its multiple sites of interaction.
Seminars in thrombosis and hemostasis 1993;19(4):321-33.
1992: Baumann U; Bode W; Huber R; Travis J; Potempa J
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution.
Journal of molecular biology 1992;226(4):1207-18.
1992: Brandstetter H; Turk D; Hoeffken H W; Grosse D; Stürzebecher J; Martin P D; Edwards B F; Bode W
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Journal of molecular biology 1992;226(4):1085-99.
1992: Stürzebecher J; Vieweg H; Wikström P; Turk D; Bode W
Interactions of thrombin with benzamidine-based inhibitors.
Biological chemistry Hoppe-Seyler 1992;373(7):491-6.
1992: Bode W; Gomis-Rüth F X; Huber R; Zwilling R; Stöcker W
Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases.
Nature 1992;358(6382):164-7.
1992: Karshikov A; Bode W; Tulinsky A; Stone S R
Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex.
Protein science : a publication of the Protein Society 1992;1(6):727-35.
1992: Stubbs M T; Oschkinat H; Mayr I; Huber R; Angliker H; Stone S R; Bode W
The interaction of thrombin with fibrinogen. A structural basis for its specificity.
European journal of biochemistry / FEBS 1992;206(1):187-95.
1992: Martin P D; Robertson W; Turk D; Huber R; Bode W; Edwards B F
The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
The Journal of biological chemistry 1992;267(11):7911-20.
1992: Bode W; Turk D; Karshikov A
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein science : a publication of the Protein Society 1992;1(4):426-71.
1992: Bode W; Huber R
Natural protein proteinase inhibitors and their interaction with proteinases.
European journal of biochemistry / FEBS 1992;204(2):433-51.
1991: Turk D; Stürzebecher J; Bode W
Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes.
FEBS letters 1991;287(1-2):133-8.
1991: Musil D; Bode W; Huber R; Laskowski M; Lin T Y; Ardelt W
Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3*) and from Japanese quail (OMJPQ3*).
Journal of molecular biology 1991;220(3):739-55.
1991: Baumann U; Huber R; Bode W; Grosse D; Lesjak M; Laurell C B
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins.
Journal of molecular biology 1991;218(3):595-606.
1991: Bode W; Huber R
Proteinase-protein inhibitor interaction.
Biomedica biochimica acta 1991;50(4-6):437-46.
1990: Bode W; Turk D; Stürzebecher J
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin. X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin.
European journal of biochemistry / FEBS 1990;193(1):175-82.
1990: Stubbs M T; Laber B; Bode W; Huber R; Jerala R; Lenarcic B; Turk V
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.
The EMBO journal 1990;9(6):1939-47.
1990: Bode W; Engh R; Musil D; Laber B; Stubbs M; Huber R; Turk V
Mechanism of interaction of cysteine proteinases and their protein inhibitors as compared to the serine proteinase-inhibitor interaction.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():111-8.
1990: Stubbs M; Summers L; Mayr I; Schneider M; Bode W; Huber R; Ries A; Kühn K
Crystals of the NC1 domain of human type IV collagen.
Journal of molecular biology 1990;211(4):683-4.
1990: Duerring M; Huber R; Bode W; Ruembeli R; Zuber H
Refined three-dimensional structure of phycoerythrocyanin from the cyanobacterium Mastigocladus laminosus at 2.7 A.
Journal of molecular biology 1990;211(3):633-44.
1989: Holak T A; Bode W; Huber R; Otlewski J; Wilusz T
Nuclear magnetic resonance solution and X-ray structures of squash trypsin inhibitor exhibit the same conformation of the proteinase binding loop.
Journal of molecular biology 1989;210(3):649-54.
1989: Bode W; Mayr I; Baumann U; Huber R; Stone S R; Hofsteenge J
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
The EMBO journal 1989;8(11):3467-75.
1989: Laber B; Krieglstein K; Henschen A; Kos J; Turk V; Huber R; Bode W
The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein.
FEBS letters 1989;248(1-2):162-8.
1989: Bode W; Meyer E; Powers J C
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
Biochemistry 1989;28(5):1951-63.
1989: Machleidt W; Thiele U; Laber B; Assfalg-Machleidt I; Esterl A; Wiegand G; Kos J; Turk V; Bode W
Mechanism of inhibition of papain by chicken egg white cystatin. Inhibition constants of N-terminally truncated forms and cyanogen bromide fragments of the inhibitor.
FEBS letters 1989;243(2):234-8.
1989: Bode W; Greyling H J; Huber R; Otlewski J; Wilusz T
The refined 2.0 A X-ray crystal structure of the complex formed between bovine beta-trypsin and CMTI-I, a trypsin inhibitor from squash seeds (Cucurbita maxima). Topological similarity of the squash seed inhibitors with the carboxypeptidase A inhibitor from potatoes.
FEBS letters 1989;242(2):285-92.
1988: Fabry S; Lehmacher A; Bode W; Hensel R
Expression of the glyceraldehyde-3-phosphate dehydrogenase gene from the extremely thermophilic archaebacterium Methanothermus fervidus in E. coli. Enzyme purification, crystallization, and preliminary crystal data.
FEBS letters 1988;237(1-2):213-7.
1988: Bode W; Engh R; Musil D; Thiele U; Huber R; Karshikov A; Brzin J; Kos J; Turk V
The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.
The EMBO journal 1988;7(8):2593-9.
1988: Wei A Z; Mayr I; Bode W
The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor.
FEBS letters 1988;234(2):367-73.
1988: Grütter M G; Fendrich G; Huber R; Bode W
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.
The EMBO journal 1988;7(2):345-51.
1987: Tschesche H; Kolkenbrock H; Bode W
The covalent structure of the elastase inhibitor from Anemonia sulcata--a "non-classical" Kazal-type protein.
Biological chemistry Hoppe-Seyler 1987;368(10):1297-304.
1987: Schirmer T; Bode W; Huber R
Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution. A common principle of phycobilin-protein interaction.
Journal of molecular biology 1987;196(3):677-95.
1985: Bode W; Epp O; Huber R; Laskowski M; Ardelt W
The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3).
European journal of biochemistry / FEBS 1985;147(2):387-95.
1985: Turk V; Brzin J; Lenarcic B; Locnikar P; Popovic T; Ritonja A; Babnik J; Bode W; Machleidt W
Structure and function of lysosomal cysteine proteinases and their protein inhibitors.
Progress in clinical and biological research 1985;180():91-103.

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