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Larry Sklar

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Ivnitski-Steele Irena; Holmes Ann R; Lamping Erwin; Monk Brian C; Cannon Richard D; Sklar Larry A
Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.
Oprea Tudor I; Bologa Cristian G; Boyer Scott; Curpan Ramona F; Glen Robert C; Hopkins Andrew L; Lipinski Christopher A; Marshall Garland R; Martin Yvonne C; Ostopovici-Halip Liliana; Rishton Gilbert; Ursu Oleg; Vaz Roy J; Waller Chris; Waldmann Herbert; Sklar Larry A
A crowdsourcing evaluation of the NIH chemical probes.
Haynes Mark K; Strouse J Jacob; Waller Anna; Leitao Andrei; Curpan Ramona F; Bologa Cristian; Oprea Tudor I; Prossnitz Eric R; Edwards Bruce S; Sklar Larry A; Thompson Todd A
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.

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All Publications

2009: Ivnitski-Steele Irena; Holmes Ann R; Lamping Erwin; Monk Brian C; Cannon Richard D; Sklar Larry A
Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.
Analytical biochemistry 2009;394(1):87-91.
2009: Oprea Tudor I; Bologa Cristian G; Boyer Scott; Curpan Ramona F; Glen Robert C; Hopkins Andrew L; Lipinski Christopher A; Marshall Garland R; Martin Yvonne C; Ostopovici-Halip Liliana; Rishton Gilbert; Ursu Oleg; Vaz Roy J; Waller Chris; Waldmann Herbert; Sklar Larry A
A crowdsourcing evaluation of the NIH chemical probes.
Nature chemical biology 2009;5(7):441-7.
2009: Haynes Mark K; Strouse J Jacob; Waller Anna; Leitao Andrei; Curpan Ramona F; Bologa Cristian; Oprea Tudor I; Prossnitz Eric R; Edwards Bruce S; Sklar Larry A; Thompson Todd A
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2009;14(6):596-609.
2009: Dennis Megan K; Burai Ritwik; Ramesh Chinnasamy; Petrie Whitney K; Alcon Sara N; Nayak Tapan K; Bologa Cristian G; Leitao Andrei; Brailoiu Eugen; Deliu Elena; Dun Nae J; Sklar Larry A; Hathaway Helen J; Arterburn Jeffrey B; Oprea Tudor I; Prossnitz Eric R
In vivo effects of a GPR30 antagonist.
Nature chemical biology 2009;5(6):421-7.
2009: Chigaev Alexandre; Waller Anna; Amit Or; Halip Liliana; Bologa Cristian G; Sklar Larry A
Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation.
The Journal of biological chemistry 2009;284(21):14337-46.
2009: Guo Haixun; Shenoy Nalini; Gershman Benjamin M; Yang Jianquan; Sklar Larry A; Miao Yubin
Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide.
Nuclear medicine and biology 2009;36(3):267-76.
2009: Strouse J Jacob; Young Susan M; Mitchell Hugh D; Ye Richard D; Prossnitz Eric R; Sklar Larry A; Edwards Bruce S
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):264-70.
2009: Young Susan M; Bologa Cristian M; Fara Dan; Bryant Bj K; Strouse Juan Jacob; Arterburn Jeffrey B; Ye Richard D; Oprea Tudor I; Prossnitz Eric R; Sklar Larry A; Edwards Bruce S
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):253-63.
2009: Buranda Tione; Wu Yang; Sklar Larry A
Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry.
Methods in enzymology 2009;461():227-47.
2009: Edwards Bruce S; Young Susan M; Ivnitsky-Steele Irena; Ye Richard D; Prossnitz Eric R; Sklar Larry A
High-content screening: flow cytometry analysis.
Methods in molecular biology (Clifton, N.J.) 2009;486():151-65.
2008: Schwartz Samantha L; Tessema Mathewos; Buranda Tione; Pylypenko Olena; Rak Alexey; Simons Peter C; Surviladze Zurab; Sklar Larry A; Wandinger-Ness Angela
Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases.
Analytical biochemistry 2008;381(2):258-66.
2008: Nayak Tapan K; Hathaway Helen J; Ramesh Chinnasamy; Arterburn Jeffrey B; Dai Donghai; Sklar Larry A; Norenberg Jeffrey P; Prossnitz Eric R
Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):978-86.
2008: Dennis Megan K; Bowles Harmony J C; MacKenzie Debra A; Burchiel Scott W; Edwards Bruce S; Sklar Larry A; Prossnitz Eric R; Thompson Todd A
A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(5):390-9.
2008: Zeineldin Reema; Piyasena Menake E; Sklar Larry A; Whitten David; Lopez Gabriel P
Detection of membrane biointeractions based on fluorescence superquenching.
Langmuir : the ACS journal of surfaces and colloids 2008;24(8):4125-31.
2008: Ivnitski-Steele Irena; Larson Richard S; Lovato Debbie M; Khawaja Hadya M; Winter Stuart S; Oprea Tudor I; Sklar Larry A; Edwards Bruce S
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters.
Assay and drug development technologies 2008;6(2):263-76.
2008: Winter Stuart S; Lovato Debbie M; Khawaja Hadya M; Edwards Bruce S; Steele Irena D; Young Susan M; Oprea Tudor I; Sklar Larry A; Larson Richard S
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2008;13(3):185-93.
2008: Prossnitz Eric R; Sklar Larry A; Oprea Tudor I; Arterburn Jeffrey B
GPR30: a novel therapeutic target in estrogen-related disease.
Trends in pharmacological sciences 2008;29(3):116-23.
2008: Chigaev Alexandre; Waller Anna; Amit Or; Sklar Larry A
Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion.
BMC immunology 2008;9():26.
2008: Salas Virginia M; Edwards Bruce S; Sklar Larry A
Advances in multiple analyte profiling.
Advances in clinical chemistry 2008;45():47-74.
2008: Prossnitz Eric R; Arterburn Jeffrey B; Smith Harriet O; Oprea Tudor I; Sklar Larry A; Hathaway Helen J
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
Annual review of physiology 2008;70():165-90.
2007: Wu Yang; Buranda Tione; Simons Peter C; Lopez Gabriel P; McIntire William E; Garrison James C; Prossnitz Eric R; Sklar Larry A
Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides.
Analytical biochemistry 2007;371(1):10-20.
2007: Naivar Mark A; Parson Jimmie D; Wilder Mark E; Habbersett Robert C; Edwards Bruce S; Sklar Larry; Nolan John P; Graves Steven W; Martin John C; Jett James H; Freyer James P
Open, reconfigurable cytometric acquisition system: ORCAS.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(11):915-24.
2007: Sklar Larry A; Carter Mark B; Edwards Bruce S
Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening.
Current opinion in pharmacology 2007;7(5):527-34.
2007: Revankar Chetana M; Mitchell Hugh D; Field Angela S; Burai Ritwik; Corona Cesear; Ramesh Chinnasamy; Sklar Larry A; Arterburn Jeffrey B; Prossnitz Eric R
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.
ACS chemical biology 2007;2(8):536-44.
2007: Simons Peter C; Young Susan M; Gibaja Veronica; Lee Wen-Cherng; Josiah Serene; Edwards Bruce S; Sklar Larry A
Duplexed, bead-based competitive assay for inhibitors of protein kinases.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(7):451-9.
2007: Chigaev Alexandre; Waller Anna; Zwartz Gordon J; Buranda Tione; Sklar Larry A
Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6828-39.
2007: Wu Yang; Campos Samuel K; Lopez Gabriel P; Ozbun Michelle A; Sklar Larry A; Buranda Tione
The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy.
Analytical biochemistry 2007;364(2):180-92.
2007: Wu Yang; Lopez Gabriel P; Sklar Larry A; Buranda Tione
Spectroscopic characterization of streptavidin functionalized quantum dots.
Analytical biochemistry 2007;364(2):193-203.
2007: Prossnitz Eric R; Arterburn Jeffrey B; Sklar Larry A
GPR30: A G protein-coupled receptor for estrogen.
Molecular and cellular endocrinology 2007;265-266():138-42.
2007: Buranda Tione; Waller Anna; Wu Yang; Simons Peter C; Biggs Sean; Prossnitz Eric R; Sklar Larry A
Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.
Advances in protein chemistry 2007;74():95-135.
2006: Ramesh Chinnasamy; Bryant Bj; Nayak Tapan; Revankar Chetana M; Anderson Tamara; Carlson Kathryn E; Katzenellenbogen John A; Sklar Larry A; Norenberg Jeffrey P; Prossnitz Eric R; Arterburn Jeffrey B
Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.
Journal of the American Chemical Society 2006;128(45):14476-7.
2006: Saunders Matthew J; Kim Heungbok; Woods Travis A; Nolan John P; Sklar Larry A; Edwards Bruce S; Graves Steven W
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(5):342-52.
2006: Zeineldin Reema; Piyasena Menake E; Bergstedt Troy S; Sklar Larry A; Whitten David; Lopez Gabriel P
Superquenching as a detector for microsphere-based flow cytometric assays.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(5):335-41.
2006: Tessema Mathewos; Simons Peter C; Cimino Daniel F; Sanchez Lilliana; Waller Anna; Posner Richard G; Wandinger-Ness Angela; Prossnitz Eric R; Sklar Larry A
Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(5):326-34.
2006: Bologa Cristian G; Revankar Chetana M; Young Susan M; Edwards Bruce S; Arterburn Jeffrey B; Kiselyov Alexander S; Parker Matthew A; Tkachenko Sergey E; Savchuck Nikolay P; Sklar Larry A; Oprea Tudor I; Prossnitz Eric R
Virtual and biomolecular screening converge on a selective agonist for GPR30.
Nature chemical biology 2006;2(4):207-12.
2006: Okun Ilya; Malarchuk Sergei; Dubrovskaya Elena; Khvat Alexander; Tkachenko Sergey; Kysil Volodymyr; Ilyin Alexey; Kravchenko Dmitry; Prossnitz Eric R; Sklar Larry; Ivachtchenko Alexandre
Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2006;11(3):277-85.
2006: Wu Yang; Buranda Tione; Metzenberg Robert L; Sklar Larry A; Lopez Gabriel P
Diazo coupling method for covalent attachment of proteins to solid substrates.
Bioconjugate chemistry 2006;17(2):359-65.
2006: Prossnitz E R; Sklar L A
Modulation of GPCR conformations by ligands, G-proteins, and arrestins.
Ernst Schering Foundation symposium proceedings 2006;(2):211-28.
2006: Edwards Bruce S; Young Susan M; Oprea Tudor I; Bologa Cristian G; Prossnitz Eric R; Sklar Larry A
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform.
Nature protocols 2006;1(1):59-66.
2005: Edwards Bruce S; Bologa Cristian; Young Susan M; Balakin Konstantin V; Prossnitz Eric R; Savchuck Nikolay P; Sklar Larry A; Oprea Tudor I
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists.
Molecular pharmacology 2005;68(5):1301-10.
2005: Wu Yang; Zwartz Gordon; Lopez Gabriel P; Sklar Larry A; Buranda Tione
Small-volume rapid-mix device for subsecond kinetic analysis in flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;67(1):37-44.
2005: Oprea Tudor I; Bologa Cristian G; Edwards Bruce S; Prossnitz Eric R; Sklar Larry A
Post-high-throughput screening analysis: an empirical compound prioritization scheme.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2005;10(5):419-26.
2005: Wu Yang; Simons Peter C; Lopez Gabriel P; Sklar Larry A; Buranda Tione
Dynamics of fluorescence dequenching of ostrich-quenched fluorescein biotin: a multifunctional quantitative assay for biotin.
Analytical biochemistry 2005;342(2):221-8.
2005: Young Susan M; Bologa Cristian; Prossnitz Eric R; Oprea Tudor I; Sklar Larry A; Edwards Bruce S
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2005;10(4):374-82.
2005: Babbitt Shalon E; Kiss Alexi; Deffenbaugh Andrew E; Chang Yie-Hwa; Bailly Eric; Erdjument-Bromage Hediye; Tempst Paul; Buranda Tione; Sklar Larry A; Baumler Jennifer; Gogol Edward; Skowyra Dorota
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle.
Cell 2005;121(4):553-65.
2005: Larson Richard S; Davis Terry; Bologa Cristian; Semenuk Gloria; Vijayan Sreejith; Li Yu; Oprea Tudor; Chigaev Alexandre; Buranda Tione; Wagner Carston R; Sklar Larry A
Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships.
Biochemistry 2005;44(11):4322-31.
2005: Revankar Chetana M; Cimino Daniel F; Sklar Larry A; Arterburn Jeffrey B; Prossnitz Eric R
A transmembrane intracellular estrogen receptor mediates rapid cell signaling.
Science (New York, N.Y.) 2005;307(5715):1625-30.
2005: Key T Alexander; Vines Charlotte M; Wagener Brant M; Gurevich Vsevolod V; Sklar Larry A; Prossnitz Eric R
Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins.
Traffic (Copenhagen, Denmark) 2005;6(2):87-99.
2004: Waller Anna; Simons Peter C; Biggs Sean M; Edwards Bruce S; Prossnitz Eric R; Sklar Larry A
Techniques: GPCR assembly, pharmacology and screening by flow cytometry.
Trends in pharmacological sciences 2004;25(12):663-9.
2004: Piyasena Menake E; Buranda Tione; Wu Yang; Huang Jinman; Sklar Larry A; Lopez Gabriel P
Near-simultaneous and real-time detection of multiple analytes in affinity microcolumns.
Analytical chemistry 2004;76(21):6266-73.
2004: Zwartz Gordon J; Chigaev Alexandre; Dwyer Denise C; Foutz Terry D; Edwards Bruce S; Sklar Larry A
Real-time analysis of very late antigen-4 affinity modulation by shear.
The Journal of biological chemistry 2004;279(37):38277-86.
2004: Edwards Bruce S; Oprea Tudor; Prossnitz Eric R; Sklar Larry A
Flow cytometry for high-throughput, high-content screening.
Current opinion in chemical biology 2004;8(4):392-8.
2004: Bartsch Joseph W; Tran Hy D; Waller Anna; Mammoli Andrea A; Buranda Tione; Sklar Larry A; Edwards Bruce S
An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system.
Analytical chemistry 2004;76(13):3810-7.
2004: Hernandez-Hansen Valerie; Smith Alexander J; Surviladze Zurab; Chigaev Alexandre; Mazel Tomas; Kalesnikoff Janet; Lowell Clifford A; Krystal Gerald; Sklar Larry A; Wilson Bridget S; Oliver Janet M
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):100-12.
2004: Chigaev Alexandre; Zwartz Gordon J; Buranda Tione; Edwards Bruce S; Prossnitz Eric R; Sklar Larry A
Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.
The Journal of biological chemistry 2004;279(31):32435-43.
2004: Sklar L A; Tsuji H; Edwards B S; Larson R S; Schuyler M
Eosinophil traffic in the circulation following allergen challenge.
Allergy 2004;59(6):596-605.
2004: Simons Peter C; Biggs Sean M; Waller Anna; Foutz Terry; Cimino Daniel F; Guo Qing; Neubig Richard R; Tang Wei-Jen; Prossnitz Eric R; Sklar Larry A
Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.
The Journal of biological chemistry 2004;279(14):13514-21.
2004: Young Susan M; Curry Mark S; Ransom John T; Ballesteros Juan A; Prossnitz Eric R; Sklar Larry A; Edwards Bruce S
High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2004;9(2):103-11.
2004: Zwartz Gordon; Chigaev Alexandre; Foutz Terry; Larson Richard S; Posner Richard; Sklar Larry A
Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress.
Biophysical journal 2004;86(2):1243-52.
2003: Chigaev Alexandre; Buranda Tione; Dwyer Denise C; Prossnitz Eric R; Sklar Larry A
FRET detection of cellular alpha4-integrin conformational activation.
Biophysical journal 2003;85(6):3951-62.
2003: Simons Peter C; Shi Mei; Foutz Terry; Cimino Daniel F; Lewis Jeremy; Buranda Tione; Lim William K; Neubig Richard R; McIntire William E; Garrison James; Prossnitz Eric; Sklar Larry A
Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.
Molecular pharmacology 2003;64(5):1227-38.
2003: Chigaev Alexandre; Zwartz Gordon; Graves Steven W; Dwyer Denise C; Tsuji Hisashi; Foutz Terry D; Edwards Bruce S; Prossnitz Eric R; Larson Richard S; Sklar Larry A
Alpha4beta1 integrin affinity changes govern cell adhesion.
The Journal of biological chemistry 2003;278(40):38174-82.
2003: Deffenbaugh Andrew E; Scaglione K Matthew; Zhang Lingxiao; Moore Johnnie M; Buranda Tione; Sklar Larry A; Skowyra Dorota
Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.
Cell 2003;114(5):611-22.
2003: Truesdell R A; Vorobieff P V; Sklar L A; Mammoli A A
Mixing of a continuous flow of two fluids due to unsteady flow.
Physical review. E, Statistical, nonlinear, and soft matter physics 2003;67(6 Pt 2):066304.
2003: Shi Mei; Bennett Teresa A; Cimino Daniel F; Maestas Diane C; Foutz Terry D; Gurevich Vsevolod V; Sklar Larry A; Prossnitz Eric R
Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins.
Biochemistry 2003;42(24):7283-93.
2003: Waller A; Simons P; Prossnitz E R; Edwards B S; Sklar L A
High throughput screening of G-protein coupled receptors via flow cytometry.
Combinatorial chemistry & high throughput screening 2003;6(4):389-97.
2003: Ramirez Sergio; Aiken Charity T; Andrzejewski Brett; Sklar Larry A; Edwards Bruce S
High-throughput flow cytometry: validation in microvolume bioassays.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;53(1):55-65.
2003: Key T Alexander; Foutz Terry D; Gurevich Vsevolod V; Sklar Larry A; Prossnitz Eric R
N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity.
The Journal of biological chemistry 2003;278(6):4041-7.
2002: Posner Richard G; Savage Paul B; Peters Adam S; Macias Angelica; DelGado Jamael; Zwartz Gordon; Sklar Larry A; Hlavacek William S
A quantitative approach for studying IgE-FcepsilonRI aggregation.
Molecular immunology 2002;38(16-18):1221-8.
2002: Kepley Christopher L; Andrews Ronald P; Brown David C; Chigaev Alexandre; Sklar Larry A; Oliver Janet M; Larson Richard S
Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils.
The Journal of allergy and clinical immunology 2002;110(3):469-75.
2002: Jackson W Coyt; Bennett T A; Edwards B S; Prossnitz E; Lopez G P; Sklar L A
Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry.
BioTechniques 2002;33(1):220-6.
2002: Buranda Tione; Huang Jinman; Perez-Luna Victor H; Schreyer Brett; Sklar Larry A; Lopez Gabriel P
Biomolecular recognition on well-characterized beads packed in microfluidic channels.
Analytical chemistry 2002;74(5):1149-56.
2002: Jackson W Coyt; Kuckuck F; Edwards B S; Mammoli A; Gallegos C M; Lopez G P; Buranda T; Sklar L A
Mixing small volumes for continuous high-throughput flow cytometry: performance of a mixing Y and peristaltic sample delivery.
Cytometry 2002;47(3):183-91.
2002: Potter Ross M; Key T Alexander; Gurevich Vsevolod V; Sklar Larry A; Prossnitz Eric R
Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus.
The Journal of biological chemistry 2002;277(11):8970-8.
2002: Graves Steven W; Nolan John P; Jett James H; Martin John C; Sklar Larry A
Nozzle design parameters and their effects on rapid sample delivery in flow cytometry.
Cytometry 2002;47(2):127-37.
2002: Pérez-Luna Víctor H; Yang Saipeng; Rabinovich Emmanuil M; Buranda Tione; Sklar Larry A; Hampton Philip D; López Gabriel P
Fluorescence biosensing strategy based on energy transfer between fluorescently labeled receptors and a metallic surface.
Biosensors & bioelectronics 2002;17(1-2):71-8.
2002: Nolan John P; Sklar Larry A
Suspension array technology: evolution of the flat-array paradigm.
Trends in biotechnology 2002;20(1):9-12.
2002: Sklar Larry A; Edwards Bruce S; Graves Steven W; Nolan John P; Prossnitz Eric R
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies.
Annual review of biophysics and biomolecular structure 2002;31():97-119.
2001: Chigaev A; Blenc A M; Braaten J V; Kumaraswamy N; Kepley C L; Andrews R P; Oliver J M; Edwards B S; Prossnitz E R; Larson R S; Sklar L A
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.
The Journal of biological chemistry 2001;276(52):48670-8.
2001: Bennett T A; Foutz T D; Gurevich V V; Sklar L A; Prossnitz E R
Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding.
The Journal of biological chemistry 2001;276(52):49195-203.
2001: Key T A; Bennett T A; Foutz T D; Gurevich V V; Sklar L A; Prossnitz E R
Regulation of formyl peptide receptor agonist affinity by reconstitution with arrestins and heterotrimeric G proteins.
The Journal of biological chemistry 2001;276(52):49204-12.
2001: Buranda T; Lopez G P; Simons P; Pastuszyn A; Sklar L A
Detection of epitope-tagged proteins in flow cytometry: fluorescence resonance energy transfer-based assays on beads with femtomole resolution.
Analytical biochemistry 2001;298(2):151-62.
2001: Bennett T A; Key T A; Gurevich V V; Neubig R; Prossnitz E R; Sklar L A
Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system.
The Journal of biological chemistry 2001;276(25):22453-60.
2001: Kuckuck F W; Edwards B S; Sklar L A
High throughput flow cytometry.
Cytometry 2001;44(1):83-90.
2001: Edwards B S; Kuckuck F W; Prossnitz E R; Ransom J T; Sklar L A
HTPS flow cytometry: a novel platform for automated high throughput drug discovery and characterization.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2001;6(2):83-90.
2001: Edwards B S; Kuckuck F W; Prossnitz E R; Okun A; Ransom J T; Sklar L A
Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology.
Cytometry 2001;43(3):211-6.
2000: Burchiel S W; Edwards B S; Kuckuck F W; Lauer F T; Prossnitz E R; Ransom J T; Sklar L A
Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications.
Methods (San Diego, Calif.) 2000;21(3):221-30.
2000: Edwards B S; Curry M S; Tsuji H; Brown D; Larson R S; Sklar L A
Expression of P-selectin at low site density promotes selective attachment of eosinophils over neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):404-10.
2000: Sklar L A; Vilven J; Lynam E; Neldon D; Bennett T A; Prossnitz E
Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis.
BioTechniques 2000;28(5):976-80, 982-5.
2000: Bennett T A; Edwards B S; Sklar L A; Rogelj S
Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4120-9.
1999: Edwards B S; Kuckuck F; Sklar L A
Plug flow cytometry: An automated coupling device for rapid sequential flow cytometric sample analysis.
Cytometry 1999;37(2):156-9.
1999: Buranda T; Lopez G P; Keij J; Harris R; Sklar L A
Peptides, antibodies, and FRET on beads in flow cytometry: A model system using fluoresceinated and biotinylated beta-endorphin.
Cytometry 1999;37(1):21-31.
1999: Prossnitz E R; Gilbert T L; Chiang S; Campbell J J; Qin S; Newman W; Sklar L A; Ye R D
Multiple activation steps of the N-formyl peptide receptor.
Biochemistry 1999;38(8):2240-7.
1999: Seamer L C; Kuckuck F; Sklar L A
Sheath fluid control to permit stable flow in rapid mix flow cytometry.
Cytometry 1999;35(1):75-9.
1999: Gilbert T L; Prossnitz E R; Sklar L A
The uncoupled state of the human formyl peptide receptor.
Journal of receptor and signal transduction research 1999;19(1-4):327-40.
1999: Jones G M; Wofsy C; Aurell C; Sklar L A
Analysis of vertical fluorescence resonance energy transfer from the surface of a small-diameter sphere.
Biophysical journal 1999;76(1 Pt 1):517-27.
1998: Lynam E; Sklar L A; Taylor A D; Neelamegham S; Edwards B S; Smith C W; Simon S I
Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells.
Journal of leukocyte biology 1998;64(5):622-30.
1998: Vilven J C; Domalewski M; Prossnitz E R; Ye R D; Muthukumaraswamy N; Harris R B; Freer R J; Sklar L A
Strategies for positioning fluorescent probes and crosslinkers on formyl peptide ligands.
Journal of receptor and signal transduction research 1998;18(2-3):187-221.
1997: Hall A L; Wilson B S; Pfeiffer J R; Oliver J M; Sklar L A
Relationship of ligand-receptor dynamics to actin polymerization in RBL-2H3 cells transfected with the human formyl peptide receptor.
Journal of leukocyte biology 1997;62(4):535-46.
1997: Larson R S; Brown D C; Sklar L A
Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2.
Blood 1997;90(7):2747-56.
1997: Lee R J; Lujan D E; Hall A L; Sklar L A; Wilson B S; Oliver J M
Cooperation between the Fc epsilonR1 and formyl peptide receptor signaling pathways in RBL(FPR) cells: the contribution of receptor-specific Ca2+ mobilization responses.
Biochemical and biophysical research communications 1997;235(3):812-9.
1997: Roslaniec M C; Bell-Prince C S; Crissman H A; Fawcett J J; Goodwin P M; Habbersett R; Jett J H; Keller R A; Martin J C; Marrone B L; Nolan J P; Park M S; Sailer B L; Sklar L A; Steinkamp J A; Cram L S
New flow cytometric technologies for the 21st century.
Human cell : official journal of Human Cell Research Society 1997;10(1):3-10.
1996: Deka C; Lehnert B E; Lehnert N M; Jones G M; Sklar L A; Steinkamp J A
Analysis of fluorescence lifetime and quenching of FITC-conjugated antibodies on cells by phase-sensitive flow cytometry.
Cytometry 1996;25(3):271-9.
1996: Guyer D A; Moore K L; Lynam E B; Schammel C M; Rogelj S; McEver R P; Sklar L A
P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation.
Blood 1996;88(7):2415-21.
1996: Lynam E B; Rogelj S; Edwards B S; Sklar L A
Enhanced aggregation of human neutrophils by MnCl2 or DTT differentiates the roles of L-selectin and beta 2-integrins.
Journal of leukocyte biology 1996;60(3):356-64.
1996: Nolan J P; Shen B; Park M S; Sklar L A
Kinetic analysis of human flap endonuclease-1 by flow cytometry.
Biochemistry 1996;35(36):11668-76.
1996: Bennett T A; Lynam E B; Sklar L A; Rogelj S
Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3093-7.
1996: Shen B; Nolan J P; Sklar L A; Park M S
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.
The Journal of biological chemistry 1996;271(16):9173-6.
1996: Wiström C A; Jones G M; Tobias P S; Sklar L A
Fluorescence resonance energy transfer analysis of lipopolysaccharide in detergent micelles.
Biophysical journal 1996;70(2):988-97.
1996: Domalewski M D; Guyer D A; Freer R J; Muthukumaraswamy N; Sklar L A
Fixation traps formyl peptide receptors in high and low affinity forms that can be regulated by GTP[S] in the absence of ligand.
Journal of receptor and signal transduction research 1996;16(1-2):59-75.
1995: Deka C; Cram L S; Habbersett R; Martin J C; Sklar L A; Steinkamp J A
Simultaneous dual-frequency phase-sensitive flow cytometric measurements for rapid identification of heterogeneous fluorescence decays in fluorochrome-labeled cells and particles.
Cytometry 1995;21(4):318-28.
1995: Nolan J P; Posner R G; Martin J C; Habbersett R; Sklar L A
A rapid mix flow cytometer with subsecond kinetic resolution.
Cytometry 1995;21(3):223-9.
1995: Bennett T A; Schammel C M; Lynam E B; Guyer D A; Mellors A; Edwards B; Rogelj S; Sklar L A
Evidence for a third component in neutrophil aggregation: potential roles of O-linked glycoproteins as L-selectin counter-structures.
Journal of leukocyte biology 1995;58(5):510-8.
1995: Simon S I; Burns A R; Taylor A D; Gopalan P K; Lynam E B; Sklar L A; Smith C W
L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1502-14.
1994: Deka C; Sklar L A; Steinkamp J A
Fluorescence lifetime measurements in a flow cytometer by amplitude demodulation using digital data acquisition technique.
Cytometry 1994;17(1):94-101.
1994: Lynam E B; Simon S I; Rochon Y P; Sklar L A
Lipopolysaccharide enhances CD11b/CD18 function but inhibits neutrophil aggregation.
Blood 1994;83(11):3303-11.
1994: Rochon Y P; Simon S I; Lynam E B; Sklar L A
A role for lectin interactions during human neutrophil aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1385-93.
1994: Posner R G; Fay S P; Domalewski M D; Sklar L A
Continuous spectrofluorometric analysis of formyl peptide receptor ternary complex interactions.
Molecular pharmacology 1994;45(1):65-73.
1993: Simon S I; Rochon Y P; Lynam E B; Smith C W; Anderson D C; Sklar L A
Beta 2-integrin and L-selectin are obligatory receptors in neutrophil aggregation.
Blood 1993;82(4):1097-106.
1993: Chambers J D; Simon S I; Berger E M; Sklar L A; Arfors K E
Endocytosis of beta 2 integrins by stimulated human neutrophils analyzed by flow cytometry.
Journal of leukocyte biology 1993;53(4):462-9.
1993: Fay S P; Domalewski M D; Sklar L A
Evidence for protonation in the human neutrophil formyl peptide receptor binding pocket.
Biochemistry 1993;32(6):1627-31.
1992: Simon S I; Chambers J D; Butcher E; Sklar L A
Neutrophil aggregation is beta 2-integrin- and L-selectin-dependent in blood and isolated cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2765-71.
1991: Fay S P; Posner R G; Swann W N; Sklar L A
Real-time analysis of the assembly of ligand, receptor, and G protein by quantitative fluorescence flow cytometry.
Biochemistry 1991;30(20):5066-75.
1991: Norgauer J; Eberle M; Fay S P; Lemke H D; Sklar L A
Kinetics of N-formyl peptide receptor up-regulation during stimulation in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):975-80.
1991: Sklar L A; Fay S P; Mueller H; Freer R J; Muthukumaraswamy N; Magde D
Conformational dynamics of the formyl peptide receptor: a prototype for studies of receptor dynamics and binding pocket structure.
Agents and actions. Supplements 1991;35():11-6.
1990: Simon S I; Chambers J D; Sklar L A
Flow cytometric analysis and modeling of cell-cell adhesive interactions: the neutrophil as a model.
The Journal of cell biology 1990;111(6 Pt 1):2747-56.
1990: Eberle M; Traynor-Kaplan A E; Sklar L A; Norgauer J
Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?
The Journal of biological chemistry 1990;265(28):16725-8.
1990: Sklar L A; Fay S P; Seligmann B E; Freer R J; Muthukumaraswamy N; Mueller H
Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance.
Biochemistry 1990;29(2):313-6.

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