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Tor Skomedal

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R I Hussain; F Afzal; J M Aronsen; Finn Olav Levy; Jan-Bjørn Osnes; Ivar Sjaastad; Tor Skomedal; Kurt A Krobert
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
Jon Riise; Tor Skomedal; Øivind Ørstavik; Christen P Dahl; Finn Olav Levy; Jan-Bjørn Osnes; Eirik Qvigstad; Kurt A Krobert
Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart.
Jon Riise; Dagny Sandnes; Tor Skomedal; Finn Olav Levy; Cam H T Nguyen; Jan-Bjørn Osnes; Christen P Dahl; Maren S Ege; Rizwan I Hussain; Kurt A Krobert
Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium.

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2013: R I Hussain; F Afzal; J M Aronsen; Finn Olav Levy; Jan-Bjørn Osnes; Ivar Sjaastad; Tor Skomedal; Kurt A Krobert
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
Journal of molecular and cellular cardiology 2013;56():129-38.
2012: Jon Riise; Tor Skomedal; Øivind Ørstavik; Christen P Dahl; Finn Olav Levy; Jan-Bjørn Osnes; Eirik Qvigstad; Kurt A Krobert
Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart.
Basic research in cardiology 2012;107(5):295.
2012: Jon Riise; Dagny Sandnes; Tor Skomedal; Finn Olav Levy; Cam H T Nguyen; Jan-Bjørn Osnes; Christen P Dahl; Maren S Ege; Rizwan I Hussain; Kurt A Krobert
Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium.
European journal of pharmacology 2012;686(1-3):66-73.
2012: Trond Brattelid; Silje V S Bekkevold; Jon Arne Kro Birkeland; Lise R Moltzau; Jan-Bjørn Osnes; Erik Qvigstad; Dagny Sandnes; Ivar Sjaastad; Tor Skomedal; Finn Olav Levy
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.
PloS one 2012;7(9):e45489.
2011: Marianne Klemp; Bent Natvig; Tor Skomedal; Ingunn Fride Tvete; Jørund Gaasemyr; Ivar Aursnes
A review and Bayesian meta-analysis of clinical efficacy and adverse effects of 4 atypical neuroleptic drugs compared with haloperidol and placebo.
Journal of clinical psychopharmacology 2011;31(6):698-704.
2011: Faraz Afzal; Jan Magnus Aronsen; Lise Román Moltzau; Jan-Bjørn Osnes; Eirik Qvigstad; Ivar Sjaastad; Tor Skomedal; Finn Olav Levy
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle.
Naunyn-Schmiedeberg's archives of pharmacology 2011;384(6):543-53.
2011: R I Hussain; F Afzal; H K Mørk; J M Aronsen; Ivar Sjaastad; Jan-Bjørn Osnes; Tor Skomedal; F O Levy; K A Krobert
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle.
British journal of pharmacology 2011;162(4):908-16.
2010: Eirik Qvigstad; Lise R Moltzau; Jan Magnus Aronsen; Cam H T Nguyen; Karina Hougen; Ivar Sjaastad; Finn Olav Levy; Tor Skomedal; Jan-Bjørn Osnes
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition.
Cardiovascular research 2010;85(4):763-72.
2009: John K Kjekshus; Christian Torp-Pedersen; Lars Gullestad; Lars Køber; Thor Edvardsen; Inge C Olsen; Ivar Sjaastad; Eirik Qvigstad; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure.
European journal of heart failure 2009;11(8):771-8.
2009: V Ansteinsson; Magne Refsnes; Tor Skomedal; Jan-Bjørn Osnes; I Schiander; Marit Låg
Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart.
Cardiovascular toxicology 2009;9(2):86-94.
2009: R I Hussain; Erik Qvigstad; Jon Arne Kro Birkeland; H Eikemo; A Glende; I Sjaastad; Tor Skomedal; Jan-Bjørn Osnes; F O Levy; Kurt A Krobert
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
British journal of pharmacology 2009;156(4):575-86.
2008: Hilde Eikemo; Tor Skomedal; Finn Olav Levy; Jan-Bjørn Osnes
Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors.
Analytical biochemistry 2008;383(2):323-5.
2008: F Afzal; Kjetil Wessel Andressen; H K Mørk; J M Aronsen; Ivar Sjaastad; C P Dahl; Tor Skomedal; Finn Olav Levy; Jan-Bjørn Osnes; Erik Qvigstad
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.
British journal of pharmacology 2008;155(7):1005-14.
2008: Jon Riise; Cam H T Nguyen; Erik Qvigstad; Dagny Sandnes; Jan-Bjørn Osnes; Tor Skomedal; Finn Olav Levy; Kurt A Krobert
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
Cardiovascular research 2008;80(3):407-15.
2008: Annike Totlandsdal; Magne Refsnes; Tor Skomedal; Jan-Bjørn Osnes; Per E Schwarze; Marit Låg
Particle-induced cytokine responses in cardiac cell cultures--the effect of particles versus soluble mediators released by particle-exposed lung cells.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):233-41.
2008: Finn Olav Levy; Erik Qvigstad; Kurt A Krobert; Tor Skomedal; Jan-Bjørn Osnes
Effects of serotonin in failing cardiac ventricle: signalling mechanisms and potential therapeutic implications.
Neuropharmacology 2008;55(6):1066-71.
2008: Annike Totlandsdal; Tor Skomedal; Marit Låg; Jan-Bjørn Osnes; Magne Refsnes
Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells.
Toxicology 2008;247(1):23-32.
2008: Leif Erik Vinge; Thomas G von Lueder; Ellen Aasum; Erik Qvigstad; Jørgen Gravning; Ole-Jakob How; Thor Edvardsen; Reidar Bjørnerheim; Mohammed Shakil Ahmed; Birthe W Mikkelsen; Erik Oie; Toril Attramadal; Tor Skomedal; Otto A Smiseth; Walter J Koch; Terje S Larsen; Håvard Attramadal
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
The Journal of biological chemistry 2008;283(16):10601-10.
2007: Trond Brattelid; Erik Qvigstad; Jon Arne Kro Birkeland; Fredrik Swift; Silje V S Bekkevold; Kurt A Krobert; Ole M Sejersted; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy; Ivar Sjaastad
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle.
Journal of molecular and cellular cardiology 2007;43(6):767-79.
2007: Leif Erik Vinge; Kjetil Wessel Andressen; Toril Attramadal; Geir Oystein Andersen; Mohammed Shakil Ahmed; Karsten Peppel; Walter J Koch; Neil J Freedman; Finn Olav Levy; Tor Skomedal; Jan-Bjørn Osnes; Håvard Attramadal
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.
Molecular pharmacology 2007;72(3):582-91.
2007: Trond Brattelid; Kristine Tveit; Jon Arne Kro Birkeland; Ivar Sjaastad; Erik Qvigstad; Kurt A Krobert; Rizwan I Hussain; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation.
Basic research in cardiology 2007;102(3):198-208.
2007: Jon Arne Kro Birkeland; Ivar Sjaastad; Trond Brattelid; Erik Qvigstad; E R Moberg; Kurt A Krobert; Reidar Bjørnerheim; Tor Skomedal; Ole M Sejersted; Jan-Bjørn Osnes; Finn Olav Levy
Effects of treatment with a 5-HT4 receptor antagonist in heart failure.
British journal of pharmacology 2007;150(2):143-52.
2006: Geir Oystein Andersen; Erik Oie; Leif Erik Vinge; Arne Yndestad; Håvard Attramadal; Tor Skomedal; Jan-Bjørn Osnes
Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts.
Basic research in cardiology 2006;101(6):471-8.
2005: Erik Qvigstad; Ivar Sjaastad; Trond Brattelid; Caroline Nunn; Fredrik Swift; Jon Arne Kro Birkeland; Kurt A Krobert; Geir Oystein Andersen; Ole M Sejersted; Jan-Bjørn Osnes; Finn Olav Levy; Tor Skomedal
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart.
Circulation research 2005;97(3):268-76.
2005: Ole J Kemi; Per Magnus Haram; Jan P Loennechen; Jan-Bjørn Osnes; Tor Skomedal; Ulrik Wisløff; Øyvind Ellingsen
Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function.
Cardiovascular research 2005;67(1):161-72.
2005: Erik Qvigstad; Ivar Sjaastad; Janny Bøkenes; Iwona Schiander; Line Solberg; Ole M Sejersted; Jan-Bjørn Osnes; Tor Skomedal
Carvedilol blockade of alpha1- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure.
European journal of pharmacology 2005;516(1):51-9.
2005: Ivar Sjaastad; Jon Arne Kro Birkeland; G Ferrier; S Howlett; Tor Skomedal; Reidar Bjørnerheim; J Andrew Wasserstrom; Ole M Sejersted
Defective excitation-contraction coupling in hearts of rats with congestive heart failure.
Acta physiologica Scandinavica 2005;184(1):45-58.
2005: Erik Qvigstad; Trond Brattelid; Ivar Sjaastad; Kjetil Wessel Andressen; Kurt A Krobert; Jon Arne Kro Birkeland; Ole M Sejersted; Alberto J Kaumann; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure.
Cardiovascular research 2005;65(4):869-78.
2005: Erik Øie; Leif Erik Vinge; Geir Oystein Andersen; Arne Yndestad; Kurt A Krobert; Cecilie Sandberg; Mohammed Shakil Ahmed; Terje Haug; Finn Olav Levy; Tor Skomedal; Håvard Attramadal
RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin.
Journal of molecular and cellular cardiology 2005;38(1):145-51.
2004: Dagny Sandnes; Laila S Nilssen; Geir Oystein Andersen; Håvard Viko; Anne E Sjetnan; Tor Skomedal; Jan-Bjørn Osnes
Ca2+-dependent elevation of inositol 1,4,5-trisphosphate level induced by freezing or homogenization of tissues and cells.
Basic & clinical pharmacology & toxicology 2004;95(6):288-94.
2004: Trond Brattelid; Erik Qvigstad; James A Lynham; Peter Molenaar; Halfdan Aass; Odd Geiran; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy; Alberto J Kaumann
Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(3):157-66.
2004: Geir Oystein Andersen; Tor Skomedal; Mette Enger; Astrid Fidjeland; Trond Brattelid; Finn Olav Levy; Jan-Bjørn Osnes
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1354-60.
2003: Erik Qvigstad; Jan-Bjørn Osnes; Dagny Sandnes; Iwona Schiander; Janny Bøkenes; Ivar Sjaastad; Tor Skomedal
Carvedilol blockade of rat myocardial alpha1-adrenoceptors.
European journal of pharmacology 2003;481(1):83-9.
2003: Vidar Beisvag; Geir Falck; Jan P Loennechen; Gunnar Qvigstad; Per Jynge; Tor Skomedal; Jan-Bjørn Osnes; Arne K Sandvik; Øyvind Ellingsen
Identification and regulation of the gastric H+/K+-ATPase in the rat heart.
Acta physiologica Scandinavica 2003;179(3):251-62.
2003: Ivar Sjaastad; Iwona Schiander; A Sjetnan; Erik Qvigstad; Janny Bøkenes; Dagny Sandnes; Jan-Bjørn Osnes; Ole M Sejersted; Tor Skomedal
Increased contribution of alpha 1- vs. beta-adrenoceptor-mediated inotropic response in rats with congestive heart failure.
Acta physiologica Scandinavica 2003;177(4):449-58.
2002: Geir Oystein Andersen; Erik Qvigstad; Iwona Schiander; Halfdan Aass; Jan-Bjørn Osnes; Tor Skomedal
Alpha(1)-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1471-80.
2001: Tor Skomedal; Halfdan Aass; Odd Geiran; Jan-Bjørn Osnes
Differential effects of cocaine on the positive inotropic effect of noradrenaline mediated by alpha1- and beta-adrenoceptors in failing human myocardium.
European journal of pharmacology 2001;419(2-3):223-30.
2000: K Borthne; A Langslet; H Lindberg; Tor Skomedal; Jan-Bjørn Osnes
Differential recruitment of alpha 1- and beta-adrenoceptors in inotropic control of atrial child myocardium by endogenous noradrenaline.
Acta physiologica Scandinavica 2000;170(1):21-31.
2000: Jan-Bjørn Osnes; Halfdan Aass; Geir Oystein Andersen; Tor Skomedal
First-line antihypertensive therapy.
Lancet 2000;356(9228):509-10.
2000: Geir Oystein Andersen; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Angiotensin II activates a bumetanide sensitive increase in 86RB+ efflux in the rat heart.
Research communications in molecular pathology and pharmacology 2000;107(1-2):89-104.
1999: T Dybvik; Jan-Bjørn Osnes; Tor Skomedal
Similar localisation of alpha1- and beta-adrenoceptors in rabbit heart in relation to sympathetic nerve endings.
European journal of pharmacology 1999;381(2-3):135-40.
1999: K Borthne; A Langslet; H Lindberg; Jan-Bjørn Osnes; Tor Skomedal
Endogenous muscarinic activity attenuates adrenergic inotropic effects in field stimulated atrial myocardium from children with congenital heart defects.
Acta physiologica Scandinavica 1999;165(1):9-13.
1998: Geir Oystein Andersen; Mette Enger; G Hege Thoresen; Tor Skomedal; Jan-Bjørn Osnes
Alpha1-adrenergic activation of myocardial Na-K-2Cl cotransport involving mitogen-activated protein kinase.
The American journal of physiology 1998;275(2 Pt 2):H641-52.
1998: Håvard Viko; Dagny Sandnes; Tor Skomedal; Jan-Bjørn Osnes
Effect of concomitant beta-adrenoceptor stimulation on alpha 1-adrenoceptor-mediated increase of inositol-1,4,5-trisphosphate mass in adult rat cardiomyocytes.
Pharmacology & toxicology 1998;83(1):23-8.
1997: Geir Oystein Andersen; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Receptor subtypes involved in the alpha1-adrenoceptor mediated increase in 86Rb+ efflux from the rat heart.
Japanese journal of pharmacology 1997;75(2):171-8.
1997: Tor Skomedal; Michael L X Fu; Ake Hjalmarson; Johan Hoebeke; Iwona Schiander; Jan-Bjørn Osnes
Anti-M2 muscarinic receptor antibodies inhibit beta-adrenoceptor-mediated inotropic response in rat myocardium.
European journal of pharmacology 1997;333(2-3):169-75.
1997: Geir Oystein Andersen; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Alpha 1-adrenoceptor mediated activation of Na/K/2Cl cotransport and K+ channels in the rat heart involves different receptor subtypes.
Research communications in molecular pathology and pharmacology 1997;96(3):329-40.
1997: Halfdan Aass; S I Johannessen; Jan-Bjørn Osnes; Tor Skomedal; K T Stokke
[Serum digitoxin in concomitant use of antiepileptics in routine therapy].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1997;117(14):2032-5.
1997: Håvard Viko; Jan-Bjørn Osnes; Dagny Sandnes; Tor Skomedal
Alpha 1-adrenoceptor subtypes involved in increased 86Rb+ influx rate and inositol 1,4,5-trisphosphate mass in adult rat cardiomyocytes.
European journal of pharmacology 1997;323(2-3):269-75.
1997: Håvard Viko; Jan-Bjørn Osnes; Tor Skomedal
The Na+/K+ATPase mediates the alpha 1-adrenoceptor stimulated increase in 86Rb(+)-uptake in isolated ventricular cardiomyocytes from adult rat heart.
Research communications in molecular pathology and pharmacology 1997;96(1):89-106.
1997: Tor Skomedal; K Borthne; Halfdan Aass; Odd Geiran; Jan-Bjørn Osnes
Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle.
The Journal of pharmacology and experimental therapeutics 1997;280(2):721-9.
1996: Håvard Viko; Jan-Bjørn Osnes; Tor Skomedal
Alpha(1)- and beta-adrenoceptor-mediated increase in 86Rb(+)-uptake in isolated cardiomyocytes from adult rat heart: evidence for interaction between the two receptor systems.
Pharmacology & toxicology 1996;79(6):287-92.
1996: S Hanem; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Inositol-1,4,5-trisphosphate mass content in isolated perfused rat heart during alpha-1-adrenoceptor stimulation.
Molecular and cellular biochemistry 1996;163-164():167-72.
1996: Geir Oystein Andersen; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Concentration-response relationship of alpha 1-adrenoceptor-stimulated increase of 86Rb+ efflux in rat heart.
Pharmacology & toxicology 1996;79(4):169-76.
1995: T Dybvik; Jan-Bjørn Osnes; Tor Skomedal
Location of alpha 1-adrenoceptors relative to beta-adrenoceptors in rat myocardium.
European journal of pharmacology 1995;281(1):21-7.
1995: K Borthne; P Hågå; A Langslet; Harald Lindberg; Tor Skomedal; Jan-Bjørn Osnes
Endogenous norepinephrine stimulates both alpha 1- and beta-adrenoceptors in myocardium from children with congenital heart defects.
Journal of molecular and cellular cardiology 1995;27(1):693-9.
1995: Håvard Viko; Jan-Bjørn Osnes; A E Sjetnan; Tor Skomedal
Improved isolation of cardiomyocytes by trypsination in addition to collagenase treatment.
Pharmacology & toxicology 1995;76(1):68-71.
1994: S Hanem; Mette Enger; Tor Skomedal; Jan-Bjørn Osnes
Increased intracellular potassium and water contents in rat heart after alpha-1-adrenoceptor stimulation.
Pharmacology & toxicology 1994;75(5):294-301.
1994: Tor Skomedal; Arne T Høstmark; Jan-Bjørn Osnes
Fat diet, osmotic fragility of erythrocytes and inotropic response of rat heart papillary muscle to noradrenaline stimulation: early appearance of the diet effect by lovastatin.
Pharmacology & toxicology 1994;75(3-4):200-5.
1994: K Borthne; P Hågå; A Langslet; Harald Lindberg; Jan-Bjørn Osnes; Tor Skomedal
Functional characterization of an ex vivo preparation of atrial myocardium from children with congenital heart defects: sensitivity to tyramine and adrenoceptor antagonists.
Journal of cardiovascular pharmacology 1994;24(3):365-71.
1994: S Hanem; Tor Skomedal; Jan-Bjørn Osnes
Alpha 1-adrenoceptor stimulation increases 86Rb+ influx in perfused rat heart.
Journal of cardiovascular pharmacology 1994;24(2):261-5.
1994: S Hanem; T Grønås; T Holten; Per Jynge; Tor Skomedal; Jan-Bjørn Osnes
Intracellular pH measured by 31P-NMR in isolated rat heart during alpha-1-adrenoceptor stimulation.
Journal of molecular and cellular cardiology 1994;26(5):669-74.
1993: S Hanem; Tor Skomedal; J Bjørn-Osnes
Increased 86Rb+ efflux from perfused rat hearts exposed to alpha 1-adrenergic stimulation.
Journal of cardiovascular pharmacology 1993;22(3):350-5.
1993: Tor Skomedal; Jan-Bjørn Osnes; S I Johannessen; P K Lund; Halfdan Aass
[Therapeutic drug monitoring with the help of serum concentration measurements. How are the analytic results distributed in a population?].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1993;113(18):2242-6.
1992: P Løkken; Tor Skomedal
[Gingival hyperplasia induced by calcium channel blockers. Rare or frequent in Norway?].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1992;112(15):1978-80.
1992: S Hanem; Tor Skomedal; Jan-Bjørn Osnes
Accumulation of potassium and calcium in rat myocardium exposed to alpha-1-adrenoceptor stimulation.
Pharmacology & toxicology 1992;70(4):303-7.
1991: Tor Skomedal; I G Schiander; E A Husøy; A Tveiten; Jan-Bjørn Osnes
Lithium increases the alpha 1-adrenoceptor mediated inotropic effect in rat heart.
Pharmacology & toxicology 1991;68(2):88-92.
1990: Tor Skomedal; Halfdan Aass; Jan-Bjørn Osnes
Both alpha 1- and beta-adrenoceptor stimulation determine the time course of the inotropic effect of noradrenaline in rabbit heart.
Pharmacology & toxicology 1990;67(2):172-7.
1990: Tor Skomedal; Halfdan Aass; Jan-Bjørn Osnes
Prazosin-sensitive component of the inotropic response to norepinephrine in rabbit heart.
The Journal of pharmacology and experimental therapeutics 1990;252(2):853-8.
1989: Jan-Bjørn Osnes; Halfdan Aass; Tor Skomedal
Adrenoceptors in myocardial regulation: concomitant contribution from both alpha- and beta-adrenoceptor stimulation to the inotropic response.
Basic research in cardiology 1989;84 Suppl 1():9-17.
1988: Tor Skomedal; I G Schiander; Jan-Bjørn Osnes
Both alpha and beta adrenoceptor-mediated components contribute to final inotropic response to norepinephrine in rat heart.
The Journal of pharmacology and experimental therapeutics 1988;247(3):1204-10.
1988: Halfdan Aass; Tor Skomedal; Jan-Bjørn Osnes
Increase of cyclic AMP in subcellular fractions of rat heart muscle after beta-adrenergic stimulation: prenalterol and isoprenaline caused different distribution of bound cyclic AMP.
Journal of molecular and cellular cardiology 1988;20(9):847-60.
1988: Tor Skomedal; I Schiander; Halfdan Aass; Jan-Bjørn Osnes
Properties of the inotropic response in rat papillary muscles to the dihydropyridine "Ca-channel activator" BAY K 8644.
Pharmacology & toxicology 1988;63(1):20-5.
1987: Tor Skomedal; I Schiander; Halfdan Aass; Jan-Bjørn Osnes
Qualitative characteristics of the mechanical response in rat papillary muscles to increase in extracellular calcium concentration.
Acta physiologica Scandinavica 1987;131(3):347-53.
1987: H B Christiansen; G I Horgmo; Tor Skomedal; Jan-Bjørn Osnes
Enhancement of the alpha-adrenergic inotropic component of noradrenaline by simultaneous stimulation of muscarinic acetylcholine receptors in rat myocardium.
European journal of pharmacology 1987;142(1):93-102.
1987: Jan-Bjørn Osnes; H B Christiansen; G I Horgmo; I G Schiander; Tor Skomedal
Alpha-adrenergic stimulation contributes to the inotropic effect of noradrenaline.
Biomedica biochimica acta 1987;46(8-9):S417-20.
1986: Halfdan Aass; Tor Skomedal; Jan-Bjørn Osnes; N B Fjeld; G Klingen; A Langslet; J Svennevig; G Semb
Noradrenaline evokes an alpha-adrenoceptor-mediated inotropic effect in human ventricular myocardium.
Acta pharmacologica et toxicologica 1986;58(1):88-90.
1985: Tor Skomedal; Halfdan Aass; Jan-Bjørn Osnes; N B Fjeld; G Klingen; A Langslet; G Semb
Demonstration of an alpha adrenoceptor-mediated inotropic effect of norepinephrine in human atria.
The Journal of pharmacology and experimental therapeutics 1985;233(2):441-6.
1984: Tor Skomedal; Halfdan Aass; Jan-Bjørn Osnes
Specific binding of [3H]prazosin to myocardial cells isolated from adult rats.
Biochemical pharmacology 1984;33(12):1897-906.
1983: Halfdan Aass; Tor Skomedal; Jan-Bjørn Osnes
Effects of trifluoperazine on beta-adrenergic responses of rat papillary muscle: related to calmodulin?
Acta pharmacologica et toxicologica 1983;53(4):265-74.
1983: Halfdan Aass; Tor Skomedal; Jan-Bjørn Osnes
Demonstration of an alpha adrenoceptor-mediated inotropic effect of norepinephrine in rabbit papillary muscle.
The Journal of pharmacology and experimental therapeutics 1983;226(2):572-8.
1983: Halfdan Aass; A Hedberg; Tor Skomedal; E Carlsson; Jan-Bjørn Osnes
Characterization of mechanical effects and beta-adrenoceptor binding of prenalterol in rat myocardium.
Acta pharmacologica et toxicologica 1983;53(1):3-11.
1983: Halfdan Aass; A Hedberg; Tor Skomedal; E Carlsson; Jan-Bjørn Osnes
Lack of functional influence by prenalterol through alpha 1-adrenoceptors in rat myocardium.
Acta pharmacologica et toxicologica 1983;53(1):12-5.
1983: Tor Skomedal; Jan-Bjørn Osnes
Qualitative differences between the inotropic responses in rat papillary muscles to alpha-adrenoceptor and beta-adrenoceptor stimulation by both noradrenaline and adrenaline.
Acta pharmacologica et toxicologica 1983;52(1):57-67.
1982: Tor Skomedal; Jan-Bjørn Osnes; I Oye
Differences between alpha-adrenergic and beta-adrenergic inotropic effects in rat heart papillary muscles.
Acta pharmacologica et toxicologica 1982;50(1):1-12.
1981: Tor Skomedal; Jan-Bjørn Osnes; I Oye
Mechanical response of rat myocardium to dibutyryl cyclic AMP in relation to effects of alpha-and beta-adrenoceptor stimulators.
Acta pharmacologica et toxicologica 1981;49(2):81-91.
1980: Tor Skomedal; Jan-Bjørn Osnes; I Oye
Competitive blockade of alpha-adrenergic receptors in rat heart by prazosin.
Acta pharmacologica et toxicologica 1980;47(3):217-22.
1980: Tor Skomedal; B Grynne; Jan-Bjørn Osnes; A E Sjetnan; I Oye
A radioimmunoassay for cyclic AMP (cAMP) obtained by acetylation of both unlabeled and labeled (3H-cAMP) ligand, or of unlabeled ligand only.
Acta pharmacologica et toxicologica 1980;46(3):200-4.