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Thomas Skopek

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Ying Jiang; David Gerhold; Daniel J Holder; David Figueroa; Wendy J Bailey; Ping Guan; Thomas R Skopek; Frank D Sistare; Joseph F Sina
Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles.
Warren E Glaab; Laurie S Mitchell; Judith E Miller; Katerina Vlasakova; Thomas R Skopek
5-fluorouracil forward mutation assay in Salmonella: determination of mutational target and spontaneous mutational spectra.
Katerina Vlasakova; Thomas R Skopek; Warren E Glaab
Induced mutation spectra at the upp locus in Salmonella typhimurium: response of the target gene in the FU assay to mechanistically different mutagens.

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All Publications

2007: Ying Jiang; David Gerhold; Daniel J Holder; David Figueroa; Wendy J Bailey; Ping Guan; Thomas R Skopek; Frank D Sistare; Joseph F Sina
Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles.
Journal of translational medicine 2007;5():47.
2005: Warren E Glaab; Laurie S Mitchell; Judith E Miller; Katerina Vlasakova; Thomas R Skopek
5-fluorouracil forward mutation assay in Salmonella: determination of mutational target and spontaneous mutational spectra.
Mutation research 2005;578(1-2):238-46.
2005: Katerina Vlasakova; Thomas R Skopek; Warren E Glaab
Induced mutation spectra at the upp locus in Salmonella typhimurium: response of the target gene in the FU assay to mechanistically different mutagens.
Mutation research 2005;578(1-2):225-37.
2005: Judith E Miller; Katerina Vlasakova; Warren E Glaab; Thomas R Skopek
A low volume, high-throughput forward mutation assay in Salmonella typhimurium based on fluorouracil resistance.
Mutation research 2005;578(1-2):210-24.
2002: M Vijayaraj Reddy; Richard D Storer; George M Laws; Michael J Armstrong; John E Barnum; Jennifer P Gara; Crystal G McKnight; Thomas R Skopek; Joseph F Sina; John G DeLuca; Sheila M Galloway
Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests.
Environmental and molecular mutagenesis 2002;40(1):1-17.
2001: George M Laws; Thomas R Skopek; M Vijayaraj Reddy; Richard D Storer; Warren E Glaab
Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan).
Mutation research 2001;484(1-2):3-18.
2001: Warren E Glaab; Rosina B Hill; Thomas R Skopek
Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells.
Carcinogenesis 2001;22(10):1709-13.
2001: JJ Monroe; M G Manjanatha; Thomas R Skopek
Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents.
Mutation research 2001;476(1-2):1-11.
2001: K B Bleicher; TR Pippert; Warren E Glaab; Thomas R Skopek; Joseph F Sina; Diane R Umbenhauer
Use of real-time gene-specific polymerase chain reaction to measure RNA expression of three family members of rat cytochrome P450 4A.
Journal of biochemical and molecular toxicology 2001;15(3):133-42.
2000: Warren E Glaab; KL Kort; Thomas R Skopek
Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair.
Cancer research 2000;60(17):4921-5.
2000: Vernon E Walker; KY Wu; Patricia B Upton; Asoka Ranasinghe; N Scheller; M H Cho; J S Vergnes; Thomas R Skopek; James A Swenberg
Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide.
Carcinogenesis 2000;21(9):1661-9.
2000: John A Heddle; S Dean; Takehiko Nohmi; ME Boerrigter; D Casciano; George R Douglas; Barry W Glickman; Nancy J Gorelick; Jon C Mirsalis; H J Martus; Thomas R Skopek; Veronique Thybaud; Kenneth Tindall; N Yajima
In vivo transgenic mutation assays.
Environmental and molecular mutagenesis 2000;35(3):253-9.
1999: Vernon E Walker; I M Jones; T L Crippen; Quanxin Meng; Dale M Walker; Michael J Bauer; AA Reilly; A D Tates; Jun Nakamura; Patricia B Upton; Thomas R Skopek
Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea.
Mutation research 1999;431(2):371-88.
1999: Thomas R Skopek; Warren E Glaab; JJ Monroe; KL Kort; W Schaefer
Analysis of sequence alterations in a defined DNA region: comparison of temperature-modulated heteroduplex analysis and denaturing gradient gel electrophoresis.
Mutation research 1999;430(1):13-21.
1999: Warren E Glaab; Thomas R Skopek
A novel assay for allelic discrimination that combines the fluorogenic 5' nuclease polymerase chain reaction (TaqMan) and mismatch amplification mutation assay.
Mutation research 1999;430(1):1-12.
1999: Warren E Glaab; Kenneth Tindall; Thomas R Skopek
Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.
Mutation research 1999;427(2):67-78.
1999: Warren E Glaab; Thomas R Skopek
Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine.
Carcinogenesis 1999;20(3):391-4.
1999: Vernon E Walker; JL Andrews; Patricia B Upton; Thomas R Skopek; J G deBoer; Dale M Walker; X Shi; HE Sussman; Nancy J Gorelick
Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice.
Environmental and molecular mutagenesis 1999;34(2-3):167-81.
1998: JJ Monroe; KL Kort; Judith E Miller; D R Marino; Thomas R Skopek
A comparative study of in vivo mutation assays: analysis of hprt, lacI, cII/cI and as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue mice.
Mutation research 1998;421(1):121-36.
1998: Sheila M Galloway; Judith E Miller; Michael J Armstrong; C L Bean; Thomas R Skopek; WW Nichols
DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens.
Mutation research 1998;400(1-2):169-86.
1998: Thomas R Skopek; D Marino; KL Kort; J Miller; Myrna E Trumbauer; S Gopal; H Chen
Effect of target gene CpG content on spontaneous mutation in299 transgenic mice.
Mutation research 1998;400(1-2):77-88.
1998: C M Vetter; Judith E Miller; L M Crawford; Michael J Armstrong; James H Clair; MW Conner; L David Wise; Thomas R Skopek
Comparison of motility and membrane integrity to assess rat sperm viability.
Reproductive toxicology (Elmsford, N.Y.) 1998;12(2):105-14.
1998: Quanxin Meng; Thomas R Skopek; Dale M Walker; S Hurley-Leslie; T Chen; D M Zimmer; Vernon E Walker
Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen.
Environmental and molecular mutagenesis 1998;32(3):236-43.
1998: Thomas R Skopek
Transgenic mutation models: research, testing, and reality checks.
Environmental and molecular mutagenesis 1998;32(2):104-5.
1996: Vernon E Walker; Nancy J Gorelick; J L Andrews; T R Craft; J G deBoer; Barry W Glickman; Thomas R Skopek
Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice.
Cancer research 1996;56(20):4654-61.
1996: T C Hunter; S B Melancon; Louis Dallaire; S Taft; Thomas R Skopek; Richard J Albertini; J Patrick O'Neill
Germinal HPRT splice donor site mutation results in multiple RNA splicing products in T-lymphocyte cultures.
Somatic cell and molecular genetics 1996;22(2):145-50.
1996: Thomas R Skopek; D R Marino; KL Kort; J Miller; TR Pippert
Synthesis of a lacI gene analogue with reduced CpG content.
Mutation research 1996;349(2):163-72.
1996: Thomas R Skopek; KL Kort; D R Marino; L V Mittal; Diane R Umbenhauer; G M Laws; S P Adams
Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice.
Environmental and molecular mutagenesis 1996;28(4):376-84.
1995: Thomas R Skopek
Of mice and mutants: target size and sensitivity.
Mutation research 1995;331(2):225-8.
1995: Ilse-Dore Adler; J Cochrane; S Osterman-Golkar; Thomas R Skopek; M Sorsa; E Vogel
1,3-Butadiene working group report.
Mutation research 1995;330(1-2):101-14.
1995: Thomas R Skopek; KL Kort; D R Marino
Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice.
Environmental and molecular mutagenesis 1995;26(1):9-15.
1994: N F Cariello; W W Piegorsch; W T Adams; Thomas R Skopek
Computer program for the analysis of mutational spectra: application to p53 mutations.
Carcinogenesis 1994;15(10):2281-5.
1994: N F Cariello; L Cui; Thomas R Skopek
In vitro mutational spectrum of aflatoxin B1 in the human hypoxanthine guanine phosphoribosyltransferase gene.
Cancer research 1994;54(16):4436-41.
1994: J E Cochrane; Thomas R Skopek
Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice.
Carcinogenesis 1994;15(4):719-23.
1994: J E Cochrane; Thomas R Skopek
Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts.
Carcinogenesis 1994;15(4):713-7.
1993: C M Denault; Thomas R Skopek; Howard Liber
The effects of hypoxia and cysteamine on X-ray mutagenesis in human cells. II. hprt mRNA expression and cDNA sequence analysis of induced mutants.
Radiation research 1993;136(2):271-9.
1993: N F Cariello; Thomas R Skopek
In vivo mutation at the human HPRT locus.
Trends in genetics : TIG 1993;9(9):322-6.
1993: Vernon E Walker; Thomas R Skopek
A mouse model for the study of in vivo mutational spectra: sequence specificity of ethylene oxide at the hprt locus.
Mutation research 1993;288(1):151-62.
1993: N F Cariello; Thomas R Skopek
Mutational analysis using denaturing gradient gel electrophoresis and PCR.
Mutation research 1993;288(1):103-12.
1993: N F Cariello; Thomas R Skopek
Analysis of mutations occurring at the human hprt locus.
Journal of molecular biology 1993;231(1):41-57.
1993: Richard J Albertini; Janice A Nicklas; James C Fuscoe; Thomas R Skopek; Richard F Branda; J Patrick O'Neill
In vivo mutations in human blood cells: biomarkers for molecular epidemiology.
Environmental health perspectives 1993;99():135-41.
1993: J E Cochrane; Thomas R Skopek
Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice.
IARC scientific publications 1993;(127):195-204.
1992: Thomas R Skopek; Vernon E Walker; J E Cochrane; T R Craft; N F Cariello
Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7866-70.
1992: Vernon E Walker; Timothy R Fennell; Patricia B Upton; Thomas R Skopek; V Prevost; D E Shuker; James A Swenberg
Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice.
Cancer research 1992;52(16):4328-34.
1992: S M Bronstein; M J Hooth; James A Swenberg; Thomas R Skopek
Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.
Cancer research 1992;52(14):3851-6.
1992: N F Cariello; James A Swenberg; Thomas R Skopek
In vitro mutational specificity of cisplatin in the human hypoxanthine guanine phosphoribosyltransferase gene.
Cancer research 1992;52(10):2866-73.
1992: S M Bronstein; Thomas R Skopek; James A Swenberg
Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.
Cancer research 1992;52(7):2008-11.
1992: N F Cariello; T R Craft; H Vrieling; A A van Zeeland; T Adams; Thomas R Skopek
Human HPRT mutant database: software for data entry and retrieval.
Environmental and molecular mutagenesis 1992;20(2):81-3.
1991: S M Bronstein; J E Cochrane; T R Craft; James A Swenberg; Thomas R Skopek
Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.
Cancer research 1991;51(19):5188-97.
1991: N F Cariello; James A Swenberg; Thomas R Skopek
Fidelity of Thermococcus litoralis DNA polymerase (Vent) in PCR determined by denaturing gradient gel electrophoresis.
Nucleic acids research 1991;19(15):4193-8.
1991: N F Cariello; W G Thilly; James A Swenberg; Thomas R Skopek
Deletion mutagenesis during polymerase chain reaction: dependence on DNA polymerase.
Gene 1991;99(1):105-8.
1991: N F Cariello; James A Swenberg; A De Bellis; Thomas R Skopek
Analysis of mutations using PCR and denaturing gradient gel electrophoresis.
Environmental and molecular mutagenesis 1991;18(4):249-54.
1990: Leslie Recio; D Simpson; J Cochrane; Howard Liber; Thomas R Skopek
Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells.
Mutation research 1990;242(3):195-208.
1990: Leslie Recio; J Cochrane; D Simpson; Thomas R Skopek; J P O'Neill; J A Nicklas; R J Albertini
DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.
Mutagenesis 1990;5(5):505-10.
1990: Thomas R Skopek; Leslie Recio; D Simpson; Louis Dallaire; S B Melancon; H Ogier; J Patrick O'Neill; M T Falta; Janice A Nicklas; Richard J Albertini
Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures.
Human genetics 1990;85(1):111-6.
1990: Richard J Albertini; J Patrick O'Neill; Janice A Nicklas; Leslie Recio; Thomas R Skopek
hprt mutations in vivo in human T-lymphocytes: frequencies, spectra and clonality.
Progress in clinical and biological research 1990;340C():15-24.
1990: William F Greenlee; Thomas R Skopek; Kevin W Gaido; C Walker
Comparative genetic mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced tumors.
Progress in clinical and biological research 1990;331():177-86.
1989: Howard Liber; K Benforado; R M Crosby; D Simpson; Thomas R Skopek
Formaldehyde-induced and spontaneous alterations in human hprt DNA sequence and mRNA expression.
Mutation research 1989;226(1):31-7.
1989: F C Richardson; J A Boucheron; Thomas R Skopek; James A Swenberg
Formation of O6-methyldeoxyguanosine at specific sites in a synthetic oligonucleotide designed to resemble a known mutagenic hotspot.
The Journal of biological chemistry 1989;264(2):838-41.
1989: Y Kodama; C J Boreiko; Thomas R Skopek; Leslie Recio
Cytogenetic analysis of spontaneous and 2-cyanoethylene oxide-induced tk-/- mutants in TK6 human lymphoblastoid cultures.
Environmental and molecular mutagenesis 1989;14(3):149-54.
1988: K K Richardson; R M Crosby; Thomas R Skopek
Mutation spectra of N-ethyl-N'-nitro-N-nitrosoguanidine and 1-(2-hydroxyethyl)-1-nitrosourea in Escherichia coli.
Molecular & general genetics : MGG 1988;214(3):460-6.
1988: Leslie Recio; Thomas R Skopek
Mutagenicity of acrylonitrile and its metabolite 2-cyanoethylene oxide in human lymphoblasts in vitro.
Mutation research 1988;206(2):297-305.
1988: D Simpson; R M Crosby; Thomas R Skopek
A method for specific cloning and sequencing of human hprt cDNA for mutation analysis.
Biochemical and biophysical research communications 1988;151(1):487-92.
1988: R M Crosby; K K Richardson; T R Craft; K B Benforado; Howard Liber; Thomas R Skopek
Molecular analysis of formaldehyde-induced mutations in human lymphoblasts and E. coli.
Environmental and molecular mutagenesis 1988;12(2):155-66.
1987: K K Richardson; R M Crosby; Frank C Richardson; Thomas R Skopek
DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine.
Molecular & general genetics : MGG 1987;209(3):526-32.
1987: W T Adams; Thomas R Skopek
Statistical test for the comparison of samples from mutational spectra.
Journal of molecular biology 1987;194(3):391-6.
1987: T R Craft; E Bermudez; Thomas R Skopek
Formaldehyde mutagenesis and formation of DNA-protein crosslinks in human lymphoblasts in vitro.
Mutation research 1987;176(1):147-55.
1987: K K Richardson; Frank C Richardson; R M Crosby; James A Swenberg; Thomas R Skopek
DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(2):344-8.
1986: K A Richardson; James Wilmer; D Smith-Simpson; Thomas R Skopek
Assessment of the genotoxic potential of unleaded gasoline and 2,2,4-trimethylpentane in human lymphoblasts in vitro.
Toxicology and applied pharmacology 1986;82(2):316-22.
1985: J Fostel; P F Allen; E Bermudez; Andrew D Kligerman; James Wilmer; Thomas R Skopek
Assessment of the genotoxic effects of methyl chloride in human lymphoblasts.
Mutation research 1985;155(1-2):75-81.
1983: K K Richardson; J Fostel; Thomas R Skopek
Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli.
Nucleic acids research 1983;11(24):8809-16.