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Tomasz Skorski

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Richard A Van Etten; Carlo Gambacorti-Passerini; John M Goldman; Rüdiger Hehlmann; Catriona Jamieson; Giovanni Martinelli; Michael Mauro; Danilo Perrotti; Jerald P Radich; Giuseppe Saglio; David T Scadden; Tomasz Skorski; Simona Soverini; Ayalew Tefferi; Tariq I Mughal
Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop.
Artur Slupianek; Tomasz Stoklosa; E Synowiec; P Znojek; A Bellacosa; Janusz Blasiak; V Doneddu; Rafal Falinski; S Flis; Dariusz Pytel; Tomasz Skorski
BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.
Krzysztof Flis; David Irvine; Ravi Bhatia; Mhairi Copland; Tomasz Skorski
Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation.

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2013: Richard A Van Etten; Carlo Gambacorti-Passerini; John M Goldman; Rüdiger Hehlmann; Catriona Jamieson; Giovanni Martinelli; Michael Mauro; Danilo Perrotti; Jerald P Radich; Giuseppe Saglio; David T Scadden; Tomasz Skorski; Simona Soverini; Ayalew Tefferi; Tariq I Mughal
Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop.
Leukemia & lymphoma 2013;54(6):1151-8.
2013: Artur Slupianek; Tomasz Stoklosa; E Synowiec; P Znojek; A Bellacosa; Janusz Blasiak; V Doneddu; Rafal Falinski; S Flis; Dariusz Pytel; Tomasz Skorski
BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.
Leukemia 2013;27(3):629-34.
2012: Krzysztof Flis; David Irvine; Ravi Bhatia; Mhairi Copland; Tomasz Skorski
Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation.
Leukemia & lymphoma 2012;53(12):2474-8.
2012: Tomasz Skorski
Genetic mechanisms of chronic myeloid leukemia blastic transformation.
Current hematologic malignancy reports 2012;7(2):87-93.
2012: Margaret Nieborowska-Skorska; Tyrone Penserga; Regina Ray; Mamatha M Reddy; Christine Richardson; Martin Sattler; Tomasz Stoklosa; Peter Valent; Heiko van der Kuip; Wieslaw Wiktor-Jedrzejczak; David A Williams; Elisabeth Bolton; Sabine Cerny-Reiterer; Kimberly Cramer; Adrienne Dorrance; Connie J Eaves; Sylwia Flis; Eliza Glodkowska-Mrowka; Andreas Hochhaus; Tessa L Holyoake; Grazyna Hoser; Timothy P Hughes; Piotr K Kopinski; Mateusz Koptyra; Danielle Ngaba; Tomasz Skorski
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.
Blood 2012;119(18):4253-63.
2011: Tomasz Skorski
BCR-ABL1 kinase: hunting an elusive target with new weapons.
Chemistry & biology 2011;18(11):1352-3.
2011: Tariq I Mughal; Alfonso Quintás-Cardama; Jerald P Radich; Farhad Ravandi; Tomasz Skorski; Daniel J DeAngelo; Carlo Gambacorti-Passerini; Giovanni Martinelli; Richard A Van Etten; Ayalew Tefferi
Chronic myeloid leukemia 2011: successes, challenges, and strategies--proceedings of the 5th annual BCR-ABL1 positive and BCR-ABL1 negative myeloproliferative neoplasms workshop.
American journal of hematology 2011;86(9):811-9.
2011: Anna Virgili; Tomasz Stoklosa; Yashodhara Dasgupta; Eliza Glodkowska-Mrowka; Mateusz Koptyra; Elisabeth P Nacheva; Tomasz Skorski
Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.
Cancer research 2011;71(16):5381-6.
2011: Mateusz Koptyra; Ilona Seferynska; Tomasz Stoklosa; Janusz Blasiak; E Glodkowska-Mrowka; Grazyna Hoser; A Klejman; Tomasz Skorski
Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis.
Leukemia 2011;25(8):1259-67.
2011: Artur Slupianek; Yashodhara Dasgupta; Milene Donlin; Fabrice Fleury; Ewa Gurdek; Margaret Nieborowska-Skorska; Shu-Yue Ren; Tomasz Skorski
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.
Blood 2011;118(4):1062-8.
2011: Tomasz Skorski
Chronic myeloid leukemia cells refractory/resistant to tyrosine kinase inhibitors are genetically unstable and may cause relapse and malignant progression to the terminal disease state.
Leukemia & lymphoma 2011;52 Suppl 1():23-9.
2011: Artur Slupianek; Tomasz Poplawski; Stanislaw K Jozwiakowski; Kimberly Cramer; Dariusz Pytel; Ewelina Stoczynska; Michal O Nowicki; Janusz Blasiak; Tomasz Skorski
BCR/ABL stimulates WRN to promote survival and genomic instability.
Cancer research 2011;71(3):842-51.
2010: Danilo Perrotti; Catriona Jamieson; John Goldman; Tomasz Skorski
Chronic myeloid leukemia: mechanisms of blastic transformation.
The Journal of clinical investigation 2010;120(7):2254-64.
2008: M Koptyra; Kimberly Cramer; Artur Slupianek; Christine Richardson; Tomasz Skorski
BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress.
Leukemia 2008;22(10):1969-72.
2008: Kimberly Cramer; Margaret Nieborowska-Skorska; Mateusz Koptyra; Artur Slupianek; Emir Tyrone P Penserga; Connie J Eaves; Walter Aulitzky; Tomasz Skorski
BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair.
Cancer research 2008;68(17):6884-8.
2008: Tomasz Sliwinski; Agnieszka Czechowska; Janusz Szemraj; Zbigniew Morawiec; Tomasz Skorski; Janusz Blasiak
STI571 reduces NER activity in BCR/ABL-expressing cells.
Mutation research 2008;654(2):162-7.
2008: Tomasz Stoklosa; Tomasz Poplawski; Mateusz Koptyra; Margaret Nieborowska-Skorska; Grzegorz Basak; Artur Slupianek; Marina Rayevskaya; Ilona Seferynska; Larry Herrera; Janusz Blasiak; Tomasz Skorski
BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations.
Cancer research 2008;68(8):2576-80.
2008: Tomasz Skorski
BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts.
Leukemia & lymphoma 2008;49(4):610-4.
2007: Lori Rink; Artur Slupianek; Tomasz Stoklosa; Margaret Nieborowska-Skorska; Krystyna Urbanska; Ilona Seferynska; Krzysztof Reiss; Tomasz Skorski
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
Blood 2007;110(2):651-60.
2007: T Mughal; J Cortes; Nicholas C P Cross; Nicholas J Donato; O Hantschel; E Jabbour; H Kantarjian; J V Melo; Tomasz Skorski; R T Silver; J M Goldman
Chronic myeloid leukemia--some topical issues.
Leukemia 2007;21(7):1347-52.
2007: Tomasz Skorski
Genomic instability: The cause and effect of BCR/ABL tyrosine kinase.
Current hematologic malignancy reports 2007;2(2):69-74.
2007: E T P Penserga; Tomasz Skorski
Fusion tyrosine kinases: a result and cause of genomic instability.
Oncogene 2007;26(1):11-20.
2006: Mateusz Koptyra; Rafal Falinski; Michal O Nowicki; Tomasz Stoklosa; Ireneusz Majsterek; Margaret Nieborowska-Skorska; Janusz Blasiak; Tomasz Skorski
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.
Blood 2006;108(1):319-27.
2006: Margaret Nieborowska-Skorska; Tomasz Stoklosa; Mandrita Datta; Agnieszka Czechowska; Lori Rink; Artur Slupianek; Mateusz Koptyra; Ilona Seferynska; Konrad Krszyna; Janusz Blasiak; Tomasz Skorski
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.
Cell cycle (Georgetown, Tex.) 2006;5(9):994-1000.
2006: Margaret Nieborowska-Skorska; Grazyna Hoser; Lori Rink; Maciej Malecki; Plamen Kossev; Mariusz A Wasik; Tomasz Skorski
Id1 transcription inhibitor-matrix metalloproteinase 9 axis enhances invasiveness of the breakpoint cluster region/abelson tyrosine kinase-transformed leukemia cells.
Cancer research 2006;66(8):4108-16.
2006: Artur Slupianek; Michal O Nowicki; Mateusz Koptyra; Tomasz Skorski
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.
DNA repair 2006;5(2):243-50.
2006: Ireneusz Majsterek; Tomasz Sliwinski; Tomasz Poplawski; Dariusz Pytel; Michal Kowalski; Artur Slupianek; Tomasz Skorski; Janusz Blasiak
Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.
Mutation research 2006;603(1):74-82.
2006: Joanna Trojanek; Sidney Croul; Thu Ho; Jin Ying Wang; Armine Darbinyan; Michal Nowicki; Luis Del Valle; Tomasz Skorski; Kamel Khalili; Krzysztof Reiss
T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.
Journal of cellular physiology 2006;206(1):35-46.
2005: Shu-Yue Ren; Fan Xue; Jan Feng; Tomasz Skorski
Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase.
Experimental hematology 2005;33(10):1222-8.
2005: Shu-Yue Ren; Elisabeth Bolton; M Golam Mohi; Andrea Morrione; Benjamin G Neel; Tomasz Skorski
Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
Molecular and cellular biology 2005;25(18):8001-8.
2005: Artur Slupianek; Ewa Gurdek; Mateusz Koptyra; Michal O Nowicki; Khwaja M Siddiqui; Joanna Groden; Tomasz Skorski
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Oncogene 2005;24(24):3914-22.
2005: Jin Ying Wang; Thu Ho; Joanna Trojanek; Janaki Chintapalli; Maja Grabacka; Tomasz Stoklosa; Fernando U Garcia; Tomasz Skorski; Krzysztof Reiss
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence.
Oncogene 2005;24(23):3748-58.
2004: Artur Slupianek; Tomasz Skorski
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
Experimental hematology 2004;32(12):1265-71.
2004: Michal O Nowicki; Rafal Falinski; Mateusz Koptyra; Artur Slupianek; Tomasz Stoklosa; Ewa Gloc; Margaret Nieborowska-Skorska; Janusz Blasiak; Tomasz Skorski
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.
Blood 2004;104(12):3746-53.
2004: Tomasz Stoklosa; Artur Slupianek; Mandrita Datta; Margaret Nieborowska-Skorska; Michal O Nowicki; Mateusz Koptyra; Tomasz Skorski
BCR/ABL recruits p53 tumor suppressor protein to induce drug resistance.
Cell cycle (Georgetown, Tex.) 2004;3(11):1463-72.
2004: Galina Chipitsyna; Dorota Slonina; Khwaja M Siddiqui; Francesca Peruzzi; Tomasz Skorski; Krzysztof Reiss; Bassel E Sawaya; Kamel Khalili; Shohreh Amini
HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression.
Oncogene 2004;23(15):2664-71.
2003: Joanna Trojanek; Thu Ho; Luis Del Valle; Michal Nowicki; Jin Ying Wang; Adam Lassak; Francesca Peruzzi; Kamel Khalili; Tomasz Skorski; Krzysztof Reiss
Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
Molecular and cellular biology 2003;23(21):7510-24.
2003: Yvan Canitrot; Rafal Falinski; Thierry Louat; Guy Laurent; Christophe Cazaux; Jean-Sébastien Hoffmann; Dominique Lautier; Tomasz Skorski
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.
Blood 2003;102(7):2632-7.
2003: Michal O Nowicki; Peter Pawlowski; Thomas Fischer; Georg Hess; Tomasz Pawlowski; Tomasz Skorski
Chronic myelogenous leukemia molecular signature.
Oncogene 2003;22(25):3952-63.
2003: Grazyna Hoser; Ireneusz Majsterek; Duane L Romana; Artur Slupianek; Janusz Blasiak; Tomasz Skorski
Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance?
Leukemia research 2003;27(3):267-73.
2002: Tomasz Skorski
BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.
Oncogene 2002;21(56):8591-604.
2002: Agata Klejman; Steven J Schreiner; Margaret Nieborowska-Skorska; Artur Slupianek; Matthew Wilson; Thomas E Smithgall; Tomasz Skorski
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
The EMBO journal 2002;21(21):5766-74.
2002: Agata Klejman; Lori Rushen; Andrea Morrione; Artur Slupianek; Tomasz Skorski
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.
Oncogene 2002;21(38):5868-76.
2002: Margaret Nieborowska-Skorska; Grazyna Hoser; Plamen Kossev; Mariusz A Wasik; Tomasz Skorski
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.
Blood 2002;99(12):4531-9.
2002: Artur Slupianek; Grazyna Hoser; Ireneusz Majsterek; Agnieszka Bronisz; Maciej Malecki; Janusz Blasiak; Richard Fishel; Tomasz Skorski
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis.
Molecular and cellular biology 2002;22(12):4189-201.
2002: Tomasz Skorski
Oncogenic tyrosine kinases and the DNA-damage response.
Nature reviews. Cancer 2002;2(5):351-60.
2002: Halina Trembacz; Joanna Miłoszewska; Bozena Szaniawska; Maciej Małecki; Malgorzata Przybyszewska; Tomasz Skorski; Przemyslaw Janik
The role of focal adhesion kinase in the emigration of cells from confluent cultures.
Cellular & molecular biology letters 2002;7(4):1047-57.
2002: Ewa Gloc; Mariusz Warszawski; Wojciech Młynarski; Malgorzata Stolarska; Grazyna Hoser; Tomasz Skorski; Janusz Błasiak
TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine.
Acta biochimica Polonica 2002;49(1):121-8.
2002: Qian Zhang; Puthiyaveettil N Raghunath; Liquan Xue; Miroslaw Majewski; David F Carpentieri; Niels Odum; Stephan Morris; Tomasz Skorski; Mariusz A Wasik
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):466-74.
2001: Artur Slupianek; Christoph Schmutte; Gregory Tombline; Margaret Nieborowska-Skorska; Grazyna Hoser; Michal O Nowicki; A J Pierce; Richard Fishel; Tomasz Skorski
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
Molecular cell 2001;8(4):795-806.
2001: Margaret Nieborowska-Skorska; Artur Slupianek; L Xue; Q Zhang; Puthiyaveettil N Raghunath; Grazyna Hoser; Mariusz A Wasik; S W Morris; Tomasz Skorski
Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.
Cancer research 2001;61(17):6517-23.
2001: Qing Wang; Hongtao Zhang; S Guerrette; J Chen; Anthony Mazurek; Teresa Wilson; Artur Slupianek; Tomasz Skorski; Richard Fishel; Mark I Greene
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
Oncogene 2001;20(34):4640-9.
2001: Artur Slupianek; Margaret Nieborowska-Skorska; Grazyna Hoser; Andrea Morrione; M Majewski; L Xue; S W Morris; Mariusz A Wasik; Tomasz Skorski
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.
Cancer research 2001;61(5):2194-9.
2000: Margaret Nieborowska-Skorska; Artur Slupianek; Tomasz Skorski
Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells.
Oncogene 2000;19(36):4117-24.
1999: SD Putney; J Brown; C Cucco; R Lee; Tomasz Skorski; Carlo Leonetti; T Geiser; Bruno Calabretta; Gabriella Zupi; G Zon
Enhanced anti-tumor effects with microencapsulated c-myc antisense oligonucleotide.
Antisense & nucleic acid drug development 1999;9(5):451-8.
1999: M Majewski; Margaret Nieborowska-Skorska; P Salomoni; Artur Slupianek; Krzysztof Reiss; Rossana Trotta; Bruno Calabretta; Tomasz Skorski
Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt.
Cancer research 1999;59(12):2815-9.
1999: Margaret Nieborowska-Skorska; Mariusz A Wasik; Artur Slupianek; P Salomoni; T Kitamura; Bruno Calabretta; Tomasz Skorski
Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis.
The Journal of experimental medicine 1999;189(8):1229-42.
1999: Renato V Iozzo; F Chakrani; Danilo Perrotti; David J McQuillan; Tomasz Skorski; Bruno Calabretta; I Eichstetter
Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3092-7.
1998: Tomasz Skorski; Pawel Wlodarski; L Daheron; P Salomoni; Margaret Nieborowska-Skorska; M Majewski; Mariusz A Wasik; Bruno Calabretta
BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11858-62.
1998: Danilo Perrotti; S Bonatti; Rossana Trotta; Robert Martinez; Tomasz Skorski; P Salomoni; E Grassilli; R V Lozzo; D R Cooper; Bruno Calabretta
TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.
The EMBO journal 1998;17(15):4442-55.
1998: P Salomoni; Mariusz A Wasik; R F Riedel; Krzysztof Reiss; John K Choi; Tomasz Skorski; Bruno Calabretta
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.
The Journal of experimental medicine 1998;187(12):1995-2007.
1998: Pawel Wlodarski; Mariusz A Wasik; Mariusz Z Ratajczak; Cinzia Sevignani; Grazyna Hoser; Jerzy Kawiak; Alan M Gewirtz; Bruno Calabretta; Tomasz Skorski
Role of p53 in hematopoietic recovery after cytotoxic treatment.
Blood 1998;91(8):2998-3006.
1998: Tomasz Skorski; Margaret Nieborowska-Skorska; Pawel Wlodarski; Mariusz A Wasik; Rossana Trotta; P Kanakaraj; P Salomoni; M Antonyak; Robert Martinez; M Majewski; A Wong; Bice Perussia; Bruno Calabretta
The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing.
Blood 1998;91(2):406-18.
1997: Tomasz Skorski; Alfonso Bellacosa; Margaret Nieborowska-Skorska; M Majewski; Robert Martinez; John K Choi; Rossana Trotta; Pawel Wlodarski; Danilo Perrotti; Tung O Chan; Mariusz A Wasik; Philip Tsichlis; Bruno Calabretta
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.
The EMBO journal 1997;16(20):6151-61.
1997: Bruno Calabretta; Tomasz Skorski
Targeting c-myc in leukemia.
Anti-cancer drug design 1997;12(5):373-81.
1997: Manoranjan Santra; D M Mann; E W Mercer; Tomasz Skorski; Bruno Calabretta; Renato V Iozzo
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.
The Journal of clinical investigation 1997;100(1):149-57.
1997: Paolo De Fabritiis; Tomasz Skorski; Maria Stefania De Propris; Marco Giorgio Paggi; Margaret Nieborowska-Skorska; A Lisci; Sonia Buffolino; K Campbell; T Geiser; Bruno Calabretta
Effect of bcr-abl oligodeoxynucleotides on the clonogenic growth of chronic myelogenous leukaemia cells.
Leukemia 1997;11(6):811-9.
1997: Tomasz Skorski; Danilo Perrotti; Margaret Nieborowska-Skorska; S Gryaznov; Bruno Calabretta
Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3966-71.
1997: Tomasz Skorski; Margaret Nieborowska-Skorska; Pawel Wlodarski; Danilo Perrotti; Grazyna Hoser; Jerzy Kawiak; M Majewski; L Christensen; Renato V Iozzo; Bruno Calabretta
Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides.
Journal of the National Cancer Institute 1997;89(2):124-33.
1997: Bruno Calabretta; Tomasz Skorski
Gene regulatory mechanisms operative on hematopoietic cells: proliferation, differentiation, and neoplasia.
Critical reviews in eukaryotic gene expression 1997;7(1-2):117-24.
1996: Tomasz Skorski; Margaret Nieborowska-Skorska; Pawel Wlodarski; Danilo Perrotti; Robert Martinez; Mariusz A Wasik; Bruno Calabretta
Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13137-42.
1996: Bruno Calabretta; Tomasz Skorski
BCR/ABL regulation of PI-3 kinase activity.
Leukemia & lymphoma 1996;23(5-6):473-6.
1996: Tomasz Skorski; Margaret Nieborowska-Skorska; Pawel Wlodarski; G Zon; Renato V Iozzo; Bruno Calabretta
Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice.
Blood 1996;88(3):1005-12.
1996: S Gryaznov; Tomasz Skorski; C Cucco; Margaret Nieborowska-Skorska; C Y Chiu; D Lloyd; J K Chen; M Koziolkiewicz; Bruno Calabretta
Oligonucleotide N3'-->P5' phosphoramidates as antisense agents.
Nucleic acids research 1996;24(8):1508-14.
1996: Bruno Calabretta; Tomasz Skorski; M Z Ratajczak; Alan M Gewirtz
Antisense strategies in the treatment of leukemias.
Seminars in oncology 1996;23(1):78-87.
1995: Tomasz Skorski; Margaret Nieborowska-Skorska; K Campbell; Renato V Iozzo; G Zon; Zbigniew Darzynkiewicz; Bruno Calabretta
Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes.
The Journal of experimental medicine 1995;182(6):1645-53.
1995: Danilo Perrotti; P Melotti; Tomasz Skorski; Ida Casella; Cesare Peschle; Bruno Calabretta
Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity.
Molecular and cellular biology 1995;15(11):6075-87.
1995: Manoranjan Santra; Tomasz Skorski; Bruno Calabretta; E C Lattime; Renato V Iozzo
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7016-20.
1995: Tomasz Skorski; P Kanakaraj; Margaret Nieborowska-Skorska; M Z Ratajczak; S C Wen; G Zon; Alan M Gewirtz; Bice Perussia; Bruno Calabretta
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells.
Blood 1995;86(2):726-36.
1995: Tomasz Skorski; Margaret Nieborowska-Skorska; C Szczylik; P Kanakaraj; Danilo Perrotti; G Zon; Alan M Gewirtz; Bice Perussia; Bruno Calabretta
C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.
Cancer research 1995;55(11):2275-8.
1994: Tomasz Skorski; P Kanakaraj; D H Ku; Margaret Nieborowska-Skorska; Eli Canaani; G Zon; Bice Perussia; Bruno Calabretta
Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.
The Journal of experimental medicine 1994;179(6):1855-65.
1994: Tomasz Skorski; Margaret Nieborowska-Skorska; N C Nicolaides; C Szczylik; P Iversen; Renato V Iozzo; G Zon; Bruno Calabretta
Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4504-8.
1993: Tomasz Skorski; P Kanakaraj; Margaret Nieborowska-Skorska; M Ratajczak; C Szczylik; G Zon; R B Arlinghaus; Alan M Gewirtz; Bice Perussia; Bruno Calabretta
p120 GAP requirement in normal and malignant human hematopoiesis.
The Journal of experimental medicine 1993;178(6):1923-33.
1993: C Szczylik; Tomasz Skorski; D H Ku; N C Nicolaides; S C Wen; L Rudnicka; A Bonati; L Malaguarnera; Bruno Calabretta
Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb.
The Journal of experimental medicine 1993;178(3):997-1005.
1993: Tomasz Skorski; Margaret Nieborowska-Skorska; C Barletta; L Malaguarnera; C Szcyzlik; S T Chen; B Lange; Bruno Calabretta
Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide.
The Journal of clinical investigation 1993;92(1):194-202.
1993: Bruno Calabretta; Tomasz Skorski; C Szczylik; G Zon
Prospects for gene-directed therapy with antisense oligodeoxynucleotides.
Cancer treatment reviews 1993;19(2):169-79.
1992: Bruno Calabretta; Tomasz Skorski; G Zon
Antisense oligonucleotides.
Seminars in cancer biology 1992;3(6):391-8.
1992: Bruno Calabretta; Tomasz Skorski; C Szczylik; D Caracciolo; Mauro Valtieri; D Venturelli
Protooncogenes in the regulation of normal hematopoiesis. An antisense approach.
Annals of the New York Academy of Sciences 1992;660():117-23.
1992: Giuseppe Raschellà; Anna Negroni; Tomasz Skorski; S Pucci; Margaret Nieborowska-Skorska; A Romeo; Bruno Calabretta
Inhibition of proliferation by c-myb antisense RNA and oligodeoxynucleotides in transformed neuroectodermal cell lines.
Cancer research 1992;52(15):4221-6.
1992: Tomasz Skorski; C Szczylik; M Z Ratajczak; L Malaguarnera; Alan M Gewirtz; Bruno Calabretta
Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxynucleotides.
The Journal of experimental medicine 1992;175(3):743-50.
1991: C Szczylik; Tomasz Skorski; N C Nicolaides; L Manzella; L Malaguarnera; D Venturelli; Alan M Gewirtz; Bruno Calabretta
Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides.
Science (New York, N.Y.) 1991;253(5019):562-5.
1990: Tomasz Skorski; Maciej Kawalec; Jerzy Kawiak
Early induction of immune resistance against leukemia in lethally total body irradiated mice reconstituted with syngeneic bone marrow cells obtained from previously immunized donor mice.
Bone marrow transplantation 1990;5(1):23-7.