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Milan Skorvaga

Research Profile

Physiology

DNA Repair

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
Qian Ruan; Tongming Liu; Alexander Kolbanovskiy; Yang Liu; Jian Ren; Milan Skorvaga; Yue Zou; Joshua Lader; Brijesh Malkani; Shantu Amin; Bennett Van Houten; Nicholas E Geacintov
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Guo Hui Jiang; Milan Skorvaga; Deborah L Croteau; Bennett Van Houten; J.Christopher States
Robust incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA adducts by a recombinant thermoresistant interspecies combination UvrABC endonuclease system.
Hong Wang; Matthew J DellaVecchia; Milan Skorvaga; Deborah L Croteau; Dorothy A Erie; Bennett Van Houten
UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity.

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All Publications

2007: Qian Ruan; Tongming Liu; Alexander Kolbanovskiy; Yang Liu; Jian Ren; Milan Skorvaga; Yue Zou; Joshua Lader; Brijesh Malkani; Shantu Amin; Bennett Van Houten; Nicholas E Geacintov
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Biochemistry 2007;46(23):7006-15.
2006: Guo Hui Jiang; Milan Skorvaga; Deborah L Croteau; Bennett Van Houten; J.Christopher States
Robust incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA adducts by a recombinant thermoresistant interspecies combination UvrABC endonuclease system.
Biochemistry 2006;45(25):7834-43.
2006: Hong Wang; Matthew J DellaVecchia; Milan Skorvaga; Deborah L Croteau; Dorothy A Erie; Bennett Van Houten
UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity.
The Journal of biological chemistry 2006;281(22):15227-37.
2005: James J Truglio; Benjamin Rhau; Deborah L Croteau; Liqun Wang; Milan Skorvaga; Erkan Karakas; Matthew J DellaVecchia; Hong Wang; Bennett Van Houten; Caroline Kisker
Structural insights into the first incision reaction during nucleotide excision repair.
The EMBO journal 2005;24(5):885-94.
2005: Toshiaki Nakano; Atsushi Katafuchi; Ryoko Shimizu; Hiroaki Terato; Toshinori Suzuki; Hiroshi Tauchi; Keisuke Makino; Milan Skorvaga; Bennett Van Houten; Hiroshi Ide
Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress.
Nucleic acids research 2005;33(7):2181-91.
2004: Milan Skorvaga; Matthew J DellaVecchia; Deborah L Croteau; Karsten Theis; James J Truglio; Bhaskar S Mandavilli; Caroline Kisker; Bennett Van Houten
Identification of residues within UvrB that are important for efficient DNA binding and damage processing.
The Journal of biological chemistry 2004;279(49):51574-80.
2004: Janine H Santos; Joel N Meyer; Milan Skorvaga; Lois A Annab; Bennett Van Houten
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
Aging cell 2004;3(6):399-411.
2004: Matthew J DellaVecchia; Deborah L Croteau; Milan Skorvaga; Sergey V Dezhurov; Olga I Lavrik; Bennett Van Houten
Analyzing the handoff of DNA from UvrA to UvrB utilizing DNA-protein photoaffinity labeling.
The Journal of biological chemistry 2004;279(43):45245-56.
2004: James J Truglio; Deborah L Croteau; Milan Skorvaga; Matthew J DellaVecchia; Karsten Theis; Bhaskar S Mandavilli; Bennett Van Houten; Caroline Kisker
Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair.
The EMBO journal 2004;23(13):2498-509.
2004: Guohui Jiang; Ryszard Jankowiak; Nenad M Grubor; Marzena Banasiewicz; Gerald J Small; Milan Skorvaga; Bennett Van Houten; J.Christopher States
Supercoiled DNA promotes formation of intercalated cis-N2-deoxyguanine adducts and base-stacked trans-N2-deoxyguanine adducts by (+)-7R,8S-dihydrodiol-9S,10R-epoxy-7,8,9,10-tetra- hydrobenzo[a]pyrene.
Chemical research in toxicology 2004;17(3):330-9.
2003: GuoHui Jiang; Milan Skorvaga; Bennett Van Houten; J.Christopher States
Reduced sulfhydryls maintain specific incision of BPDE-DNA adducts by recombinant thermoresistant Bacillus caldotenax UvrABC endonuclease.
Protein expression and purification 2003;31(1):88-98.
2003: Rachelle J Bienstock; Milan Skorvaga; Bhaskar S Mandavilli; Bennett Van Houten
Structural and functional characterization of the human DNA repair helicase XPD by comparative molecular modeling and site-directed mutagenesis of the bacterial repair protein UvrB.
The Journal of biological chemistry 2003;278(7):5309-16.
2002: Milan Skorvaga; Karsten Theis; Bhaskar S Mandavilli; Caroline Kisker; Bennett Van Houten
The beta -hairpin motif of UvrB is essential for DNA binding, damage processing, and UvrC-mediated incisions.
The Journal of biological chemistry 2002;277(2):1553-9.
2000: S Hoare; Yue Zou; V Purohit; R Krishnasamy; Milan Skorvaga; Bennett Van Houten; Nicholas E Geacintov; Ashis K Basu
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
Biochemistry 2000;39(40):12252-61.
2000: Karsten Theis; Milan Skorvaga; Mischa Machius; N Nakagawa; Bennett Van Houten; Caroline Kisker
The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch.
Mutation research 2000;460(3-4):277-300.
1999: Karsten Theis; P J Chen; Milan Skorvaga; Bennett Van Houten; Caroline Kisker
Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
The EMBO journal 1999;18(24):6899-907.