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Jerauld Skotnicki
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Research Profile (preview)
Chemicals & Drugs
Concepts & Ideas
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Disorders
Procedures
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Network (preview)
20
Levin, Jeremy
14
Jin, Guixian
13
DiJoseph, John
12
Killar, Loran
12
Sung, Amy
12
Zask, Arie
11
Sharr, Michele
11
Cowling, Rebecca
7
Barone, Dauphine
7
Chen, James
6
Mohler, Ken
6
Xu, Jun
5
Xu, Weixin
5
Roth, Catherine
5
Nelson, Frances
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Publications
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Geonetwork of Jerauld Skotnicki (preview)
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All Publications
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2009: Li Wei; Hu Yonghan; Li Jianchang; Thomason Jennifer R; DeVincentis Dianne; Du Xuemei; Wu Junjun; Hotchandani Rajeev; Rush Thomas S; Skotnicki Jerauld S; Tam Steve; Chockalingam Priya S; Morris Elisabeth A; Levin Jeremy I
3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Bioorganic & medicinal chemistry letters 2009;19(16):4546-50.
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2009: Crabtree Judy S; Jelinsky Scott A; Harris Heather A; Choe Sung E; Cotreau Monette M; Kimberland Michelle L; Wilson Ewa; Saraf Kathryn A; Liu Wei; McCampbell Adrienne S; Dave Bhuvanesh; Broaddus Russell R; Brown Eugene L; Kao Wenling; Skotnicki Jerauld S; Abou-Gharbia Magid; Winneker Richard C; Walker Cheryl L
Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway.
Cancer research 2009;69(15):6171-8.
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2009: Hopper Darrin W; Vera Matthew D; How David; Sabatini Joshua; Xiang Jason S; Ipek Manus; Thomason Jennifer; Hu Yonghan; Feyfant Eric; Wang Qin; Georgiadis Katy E; Reifenberg Erica; Sheldon Richard T; Keohan Cristin C; Majumdar Manas K; Morris Elisabeth A; Skotnicki Jerauld; Sum Phaik-Eng
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(9):2487-91.
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2006: Levin J I; Chen J M; Laakso L M; Du M; Schmid J; Xu W; Cummons T; Xu J; Jin G; Barone D; Skotnicki J S
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2006;16(6):1605-9.
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2006: Zhu Tianmin; Gu Jianxin; Yu Ker; Lucas Judy; Cai Ping; Tsao Russ; Gong Yumin; Li Fangbiao; Chaudhary Inder; Desai Parimal; Ruppen Mark; Fawzi Mahdi; Gibbons James; Ayral-Kaloustian Semiramis; Skotnicki Jerauld; Mansour Tarek; Zask Arie
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
Journal of medicinal chemistry 2006;49(4):1373-8.
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2005: Hu Yonghan; Xiang Jason S; DiGrandi Martin J; Du Xuemei; Ipek Manus; Laakso Leif M; Li Jianchang; Li Wei; Rush Thomas S; Schmid Jean; Skotnicki Jerauld S; Tam Steve; Thomason Jennifer R; Wang Qin; Levin Jeremy I
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorganic & medicinal chemistry 2005;13(24):6629-44.
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2005: Li Jianchang; Rush Thomas S; Li Wei; DeVincentis Dianne; Du Xuemei; Hu Yonghan; Thomason Jennifer R; Xiang Jason S; Skotnicki Jerauld S; Tam Steve; Cunningham Kristina M; Chockalingam Priya S; Morris Elisabeth A; Levin Jeremy I
Synthesis and SAR of highly selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(22):4961-6.
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2005: Levin J I; Chen J M; Laakso L M; Du M; Du X; Venkatesan A M; Sandanayaka V; Zask A; Xu J; Xu W; Zhang Y; Skotnicki J S
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2005;15(19):4345-9.
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2005: Wu Junjun; Rush Thomas S; Hotchandani Rajeev; Du Xuemei; Geck Mary; Collins Elisabeth; Xu Zhang-Bao; Skotnicki Jerry; Levin Jeremy I; Lovering Frank E
Identification of potent and selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):4105-9.
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2005: Yu Ker; Lucas Judy; Zhu Tianmin; Zask Arie; Gaydos Christine; Toral-Barza Lourdes; Gu Jianxin; Li Fangbiao; Chaudhary Inder; Cai Ping; Lotvin Jason; Petersen Roseann; Ruppen Mark; Fawzi Mahdi; Ayral-Kaloustian Semiramis; Skotnicki Jerauld; Mansour Tarek; Frost Philip; Gibbons James
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Cancer biology & therapy 2005;4(5):538-45.
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2005: Zask Arie; Kaplan Joshua; Du XueMei; MacEwan Gloria; Sandanayaka Vincent; Eudy Nancy; Levin Jeremy; Jin Guixian; Xu Jun; Cummons Terri; Barone Dauphine; Ayral-Kaloustian Semiramis; Skotnicki Jerauld
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(6):1641-5.
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2004: Venkatesan Aranapakam M; Davis Jamie M; Grosu George T; Baker Jannie; Zask Arie; Levin Jeremy I; Ellingboe John; Skotnicki Jerauld S; Dijoseph John F; Sung Amy; Jin Guixian; Xu Weixin; McCarthy Diane Joseph; Barone Dauphine
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(25):6255-69.
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2004: Zhang Yuhua; Hegen Martin; Xu Jun; Keith James C; Jin Guixian; Du Xuemei; Cummons Terri; Sheppard Barbara J; Sun LinHong; Zhu Yi; Rao Vikram R; Wang Qin; Xu Weixin; Cowling Rebecca; Nickerson-Nutter Cheryl L; Gibbons Jay; Skotnicki Jerry; Lin Lih-Ling; Levin Jeremy
Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme.
International immunopharmacology 2004;4(14):1845-57.
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2004: Zhang Yuhua; Xu Jun; Levin Jeremy; Hegen Martin; Li Guangde; Robertshaw Heidi; Brennan Fionula; Cummons Terri; Clarke Dave; Vansell Nichole; Nickerson-Nutter Cheryl; Barone Dauphine; Mohler Ken; Black Roy; Skotnicki Jerry; Gibbons Jay; Feldmann Marc; Frost Philip; Larsen Glenn; Lin Lih-Ling
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2004;309(1):348-55.
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2003: Skotnicki Jerauld S; DiGrandi Martin J; Levin Jeremy I
Design strategies for the identification of MMP-13 and Tace inhibitors.
Current opinion in drug discovery & development 2003;6(5):742-59.
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2003: Levin J I; Chen J M; Cheung K; Cole D; Crago C; Santos E Delos; Du X; Khafizova G; MacEwan G; Niu C; Salaski E J; Zask A; Cummons T; Sung A; Xu J; Zhang Y; Xu W; Ayral-Kaloustian S; Jin G; Cowling R; Barone D; Mohler K M; Black R A; Skotnicki J S
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Bioorganic & medicinal chemistry letters 2003;13(16):2799-803.
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2003: Li Zhong; Francisco Gerardo D; Hu William; Labthavikul Pornpen; Petersen Peter J; Severin Anatoly; Singh Guy; Yang Youjun; Rasmussen Beth A; Lin Yang-I; Skotnicki Jerauld S; Mansour Tarek S
2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis.
Bioorganic & medicinal chemistry letters 2003;13(15):2591-4.
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2003: Aranapakam Venkatesan; Davis Jamie M; Grosu George T; Baker Jannie; Ellingboe John; Zask Arie; Levin Jeremy I; Sandanayaka Vincent P; Du Mila; Skotnicki Jerauld S; DiJoseph John F; Sung Amy; Sharr Michele A; Killar Loran M; Walter Thomas; Jin Guixian; Cowling Rebecca; Tillett Jeff; Zhao Weiguang; McDevitt Joseph; Xu Zhang Bao
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
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2003: Aranapakam Venkatesan; Grosu George T; Davis Jamie M; Hu Baihua; Ellingboe John; Baker Jannie L; Skotnicki Jerauld S; Zask Arie; DiJoseph John F; Sung Amy; Sharr Michele A; Killar Loran M; Walter Thomas; Jin Guixian; Cowling Rebecca
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2361-75.
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2003: Zask A; Gu Y; Albright J D; Du X; Hogan M; Levin J I; Chen J M; Killar L M; Sung A; DiJoseph J F; Sharr M A; Roth C E; Skala S; Jin G; Cowling R; Mohler K M; Barone D; Black R; March C; Skotnicki J S
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
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2002: Nelson Frances C; Delos Santos Efren; Levin Jeremy I; Chen James M; Skotnicki Jerauld S; DiJoseph John F; Sharr Michele A; Sung Amy; Killar Loran M; Cowling Rebecca; Jin Guixian; Roth Catherine E; Albright J Donald
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
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2002: Levin J I; Chen J M; Du M T; Nelson F C; Killar L M; Skala S; Sung A; Jin G; Cowling R; Barone D; March C J; Mohler K M; Black R A; Skotnicki J S
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Bioorganic & medicinal chemistry letters 2002;12(8):1199-202.
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2001: Levin J I; Chen J M; Du M T; Nelson F C; Wehr T; DiJoseph J F; Killar L M; Skala S; Sung A; Sharr M A; Roth C E; Jin G; Cowling R; Di L; Sherman M; Xu Z B; March C J; Mohler K M; Black R A; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
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2001: Yu K; Toral-Barza L; Discafani C; Zhang W G; Skotnicki J; Frost P; Gibbons J J
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.
Endocrine-related cancer 2001;8(3):249-58.
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2001: Levin J I; Chen J; Du M; Hogan M; Kincaid S; Nelson F C; Venkatesan A M; Wehr T; Zask A; DiJoseph J; Killar L M; Skala S; Sung A; Sharr M; Roth C; Jin G; Cowling R; Mohler K M; Black R A; March C J; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
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2001: Levin J I; Gu Y; Nelson F C; Zask A; DiJoseph J F; Sharr M A; Sung A; Jin G; Cowling R; Chanda P; Cosmi S; Hsiao C L; Edris W; Wilhelm J; Killar L M; Skotnicki J S
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
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2001: Levin J I; Du M T; DiJoseph J F; Killar L M; Sung A; Walter T; Sharr M A; Roth C E; Moy F J; Powers R; Jin G; Cowling R; Skotnicki J S
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.
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1999: Skotnicki J S; Zask A; Nelson F C; Albright J D; Levin J I
Design and synthetic considerations of matrix metalloproteinase inhibitors.
Annals of the New York Academy of Sciences 1999;878():61-72.
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1999: Moy F J; Chanda P K; Chen J M; Cosmi S; Edris W; Skotnicki J S; Wilhelm J; Powers R
NMR solution structure of the catalytic fragment of human fibroblast collagenase complexed with a sulfonamide derivative of a hydroxamic acid compound.
Biochemistry 1999;38(22):7085-96.
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1998: Levin J I; DiJoseph J F; Killar L M; Sung A; Walter T; Sharr M A; Roth C E; Skotnicki J S; Albright J D
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2657-62.
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1998: Levin J I; DiJoseph J F; Killar L M; Sharr M A; Skotnicki J S; Patel D V; Xiao X Y; Shi L; Navre M; Campbell D A
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(10):1163-8.
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1998: Campbell D A; Xiao X Y; Harris D; Ida S; Mortezaei R; Ngu K; Shi L; Tien D; Wang Y; Navre M; Patel D V; Sharr M A; DiJoseph J F; Killar L M; Leone C L; Levin J I; Skotnicki J S
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(10):1157-62.
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1991: Caccese R G; DiJoseph J F; Skotnicki J S; Borella L E; Adams L M
Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989.
Agents and actions 1991;34(1-2):223-5.
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