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Susan Slanina

Research Profile

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TOP 3
Guey Chuen Perng; Barak Maguen; Ling Jin; Kevin Mott; Nelson Osorio; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Anthony B Nesburn; Melissa Inman; Gail Henderson; Clinton Jones; Steven L Wechsler
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels.
Guey Chuen Perng; D Esmaili; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Nelson Osorio; Kevin Mott; Barak Maguen; Ling Jin; Anthony B Nesburn; Steven L Wechsler
Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.
Guey Chuen Perng; Susan M Slanina; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
The effect of latency-associated transcript on the herpes simplex virus type 1 latency-reactivation phenotype is mouse strain-dependent.

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All Publications

2002: Guey Chuen Perng; Barak Maguen; Ling Jin; Kevin Mott; Nelson Osorio; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Anthony B Nesburn; Melissa Inman; Gail Henderson; Clinton Jones; Steven L Wechsler
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels.
Journal of virology 2002;76(3):1224-35.
2001: Guey Chuen Perng; D Esmaili; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Nelson Osorio; Kevin Mott; Barak Maguen; Ling Jin; Anthony B Nesburn; Steven L Wechsler
Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.
Journal of virology 2001;75(19):9018-28.
2001: Guey Chuen Perng; Susan M Slanina; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
The effect of latency-associated transcript on the herpes simplex virus type 1 latency-reactivation phenotype is mouse strain-dependent.
The Journal of general virology 2001;82(Pt 5):1117-22.
2000: Guey Chuen Perng; Clinton Jones; JR Ciacci-Zanella; M Stone; Gail Henderson; Ada Yukht; Susan M Slanina; Florence M Hofman; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.
Science (New York, N.Y.) 2000;287(5457):1500-3.
2000: Guey Chuen Perng; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.
Journal of virology 2000;74(4):1885-91.
1999: Guey Chuen Perng; Susan M Slanina; Ada Yukht; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses.
Journal of virology 1999;73(11):9669-72.
1999: Homayon Ghiasi; Steve Cai; Susan M Slanina; Guey Chuen Perng; Anthony B Nesburn; Steven L Wechsler
The role of interleukin (IL)-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease.
The Journal of infectious diseases 1999;179(5):1086-93.
1999: Guey Chuen Perng; Susan M Slanina; Ada Yukht; BS Drolet; W Keleher; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation.
Journal of virology 1999;73(2):920-9.
1999: BS Drolet; Guey Chuen Perng; R J Villosis; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency-associated transcript (LAT) partially restores wild-type spontaneous reactivation to a LAT-null mutant.
Virology 1999;253(1):96-106.
1998: Anthony B Nesburn; RL Burke; Homayon Ghiasi; Susan M Slanina; Steven L Wechsler
Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus-specific tear secretory immunoglobulin A than systemic vaccination and provides protection against recurrent spontaneous ocular shedding of virus in latently infected rabbits.
Virology 1998;252(1):200-9.
1998: Anthony B Nesburn; Susan M Slanina; RL Burke; Homayon Ghiasi; S Bahri; Steven L Wechsler
Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits.
Journal of virology 1998;72(10):7715-21.
1998: Anthony B Nesburn; RL Burke; Homayon Ghiasi; Susan M Slanina; Steven L Wechsler
A therapeutic vaccine that reduces recurrent herpes simplex virus type 1 corneal disease.
Investigative ophthalmology & visual science 1998;39(7):1163-70.
1998: BS Drolet; Guey Chuen Perng; J Cohen; Susan M Slanina; Ada Yukht; Anthony B Nesburn; Steven L Wechsler
The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein.
Virology 1998;242(1):221-32.
1997: Homayon Ghiasi; D C Roopenian; Susan M Slanina; Steve Cai; Anthony B Nesburn; Steven L Wechsler
The importance of MHC-I and MHC-II responses in vaccine efficacy against lethal herpes simplex virus type 1 challenge.
Immunology 1997;91(3):430-5.
1997: Homayon Ghiasi; Steve Cai; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
Nonneutralizing antibody against the glycoprotein K of herpes simplex virus type-1 exacerbates herpes simplex virus type-1-induced corneal scarring in various virus-mouse strain combinations.
Investigative ophthalmology & visual science 1997;38(6):1213-21.
1996: Guey Chuen Perng; Homayon Ghiasi; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation.
Journal of virology 1996;70(5):2883-93.
1996: Guey Chuen Perng; Susan M Slanina; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1.
Journal of virology 1996;70(3):2014-8.
1996: Guey Chuen Perng; Homayon Ghiasi; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.
Journal of virology 1996;70(2):976-84.
1996: Guey Chuen Perng; Kulkanya Chokephaibulkit; R L Thompson; N M Sawtell; Susan M Slanina; Homayon Ghiasi; Anthony B Nesburn; Steven L Wechsler
The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation.
Journal of virology 1996;70(1):282-91.
1995: Homayon Ghiasi; Steve Cai; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge.
Antiviral research 1995;28(2):147-57.
1995: Guey Chuen Perng; R L Thompson; N M Sawtell; W E Taylor; Susan M Slanina; Homayon Ghiasi; Ravi Kaiwar; Anthony B Nesburn; Steven L Wechsler
An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation.
Journal of virology 1995;69(5):3033-41.
1994: Guey Chuen Perng; E C Dunkel; P A Geary; Susan M Slanina; Homayon Ghiasi; Ravi Kaiwar; Anthony B Nesburn; Steven L Wechsler
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
Journal of virology 1994;68(12):8045-55.
1994: Anthony B Nesburn; R L Burke; Homayon Ghiasi; Susan M Slanina; S Bahri; Steven L Wechsler
Vaccine therapy for ocular herpes simplex virus (HSV) infection: periocular vaccination reduces spontaneous ocular HSV type 1 shedding in latently infected rabbits.
Journal of virology 1994;68(8):5084-92.
1994: Homayon Ghiasi; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
Characterization of baculovirus-expressed herpes simplex virus type 1 glycoprotein K.
Journal of virology 1994;68(4):2347-54.
1994: Homayon Ghiasi; Ravi Kaiwar; Anthony B Nesburn; Susan M Slanina; Steven L Wechsler
Expression of seven herpes simplex virus type 1 glycoproteins (gB, gC, gD, gE, gG, gH, and gI): comparative protection against lethal challenge in mice.
Journal of virology 1994;68(4):2118-26.
1994: Homayon Ghiasi; Ravi Kaiwar; Susan M Slanina; Anthony B Nesburn; Steven L Wechsler
Expression and characterization of baculovirus expressed herpes simplex virus type 1 glycoprotein L.
Archives of virology 1994;138(3-4):199-212.
1992: Homayon Ghiasi; Ravi Kaiwar; Anthony B Nesburn; Susan M Slanina; Steven L Wechsler
Baculovirus-expressed glycoprotein E (gE) of herpes simplex virus type-1 (HSV-1) protects mice against lethal intraperitoneal and lethal ocular HSV-1 challenge.
Virology 1992;188(2):469-76.
1990: J C Zwaagstra; Homayon Ghiasi; Susan M Slanina; Anthony B Nesburn; S C Wheatley; K Lillycrop; J Wood; D S Latchman; K Patel; Steven L Wechsler
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.
Journal of virology 1990;64(10):5019-28.
1988: Steven L Wechsler; Anthony B Nesburn; R Watson; Susan M Slanina; Homayon Ghiasi
Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans.
The Journal of general virology 1988;69 ( Pt 12)():3101-6.
1988: Steven L Wechsler; Anthony B Nesburn; R Watson; Susan M Slanina; Homayon Ghiasi
Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames.
Journal of virology 1988;62(11):4051-8.